Hub : Genes

ENSRNOG00000066458

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	ENSRNOT00000095915	0.07	0.05	2.7e-08	0.08	0.06	0.07	0.07	5.9e-09	1.8e-07	3.6e-08	4.2e-08
2	Liver	alternative TSS	ENSRNOT00000096628	0.07	0.04	4.0e-08	0.07	0.06	0.06	0.06	1.7e-08	4.9e-07	1.3e-07	1.4e-07
3	Liver	gene expression	ENSRNOG00000066458	0.22	0.09	0.0e+00	0.15	0.16	0.16	0.16	2.0e-16	7.3e-18	8.9e-18	6.8e-18
4	Liver	mRNA stability	ENSRNOG00000066458	0.2	0.08	0.0e+00	0.2	0.22	0.21	0.21	2.2e-21	5.3e-24	1.7e-22	3.7e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	5.0	16.3	19.3	4.0	-4.0	-3.7	4.4
BMI without tail	3.8	8.0	8.3	2.9	-2.9	-2.7	2.9
Body weight	2.4	10.0	13.4	3.1	-3.1	-2.7	3.7
Epididymis fat weight	1.4	3.2	5.5	1.8	-1.8	-1.1	2.4
Glucose	0.6	0.9	1.2	-1.0	1.0	1.1	-0.7
Heart weight	0.3	0.4	1.0	-0.5	0.5	0.2	-1.0
Left kidney weight	5.0	14.4	14.9	3.9	-3.9	-3.6	3.9
Right kidney weight	8.8	25.0	28.4	5.0	-5.0	-4.6	5.3
Tail length	0.4	1.1	1.1	-1.0	1.0	1.1	-1.0
Length with tail	0.1	0.3	0.6	-0.6	0.6	0.7	-0.1
Length without tail	0.3	0.6	1.1	0.7	-0.7	-0.5	1.1
Liver weight, left	0.2	0.3	0.5	-0.6	0.6	0.7	-0.1
Liver weight, right	1.3	2.2	3.3	-1.6	1.6	1.8	-0.8
Parametrial fat weight	0.1	0.1	0.3	0.4	-0.4	-0.5	0.2
Retroperitoneal fat weight	1.3	4.4	5.8	2.1	-2.1	-1.8	2.4
Intraocular pressure	0.0	0.0	0.0	-0.1	0.1	0.2	-0.1
Extensor digitorum longus weight	0.3	1.4	1.4	1.2	-1.2	-1.1	1.2
Soleus weight	0.9	2.8	2.8	1.7	-1.7	-1.6	1.7
Tibialis anterior weight	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2
Tibia length	1.9	5.3	5.9	-2.4	2.4	2.2	-2.2
Number of licking bursts	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.2
Food consumed during 24 hour testing period	2.9	3.4	3.6	1.9	-1.9	-1.8	1.9
Times rat made contact with spout	1.0	1.1	2.3	1.0	-1.0	-1.5	0.4
Mean time between licks in bursts	2.3	3.2	4.9	-1.7	1.7	1.4	-2.2
Mean num. licks in bursts	0.1	0.1	0.2	0.2	-0.2	-0.4	0.1
Std. dev. time between licks in bursts	0.9	1.1	2.1	1.0	-1.0	-0.6	1.4
Water consumed over 24 hours	0.4	0.5	0.7	0.7	-0.7	-0.7	0.8
Indifference point 0 sec	0.3	0.4	0.6	0.6	-0.6	-0.6	0.8
Indifference point AUC	0.6	0.7	1.7	-0.7	0.7	1.3	0.2
Indifference point function ln k	2.3	3.2	4.0	1.8	-1.8	-2.0	1.6
Indifference point function log k	2.3	3.2	4.0	1.8	-1.8	-2.0	1.6
Delay discounting total patch changes 0 sec	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4
Delay discounting total patch changes 12 sec	0.1	0.1	0.3	-0.1	0.1	0.5	0.4
Delay discounting total patch changes 18 sec	1.7	2.3	3.2	-1.5	1.5	1.8	-1.1
Delay discounting total patch changes 24 sec	0.5	0.6	0.9	-0.7	0.7	0.9	-0.5
Delay discounting total patch changes 6 sec	0.1	0.1	0.2	-0.1	0.1	0.4	0.5
Delay discounting time to switch 0 sec	0.3	0.5	0.8	-0.7	0.7	0.6	-0.9
Delay discounting water rate 0 sec	0.8	1.3	1.4	1.1	-1.1	-1.2	1.1
Delay discounting water rate 12 sec	2.0	2.9	3.1	1.7	-1.7	-1.7	1.8
Delay discounting water rate 18 sec	3.8	5.0	5.9	2.2	-2.2	-2.4	2.0
Delay discounting water rate 24 sec	1.6	2.2	2.8	1.5	-1.5	-1.7	1.1
Delay discounting water rate 6 sec	0.8	1.2	1.3	1.1	-1.1	-1.1	1.0
Locomotor activity	0.2	0.3	0.8	0.5	-0.5	-0.2	0.9
Locomotor testing distance	0.4	0.7	0.9	-0.8	0.8	0.7	-0.9
Locomotor testing rearing	0.4	0.6	1.3	-0.7	0.7	1.2	0.0
Light reinforcement 1	0.4	0.7	1.2	0.8	-0.8	-0.4	1.1
Light reinforcement 2	2.2	2.9	5.3	1.6	-1.6	-1.1	2.3
Reaction time number correct	0.6	0.9	1.3	-0.9	0.9	0.8	-1.2
Reaction time mean minus median	0.1	0.1	0.1	0.3	-0.3	-0.2	0.4
Reaction time mean minus median AUC	0.2	0.2	0.2	0.5	-0.5	-0.4	0.4
Reaction time num false alarms	0.1	0.1	0.1	-0.2	0.2	0.3	-0.4
Reaction time num false alarms AUC	0.0	0.0	0.2	-0.1	0.1	-0.0	-0.4
Reaction time trials correct on left	0.6	0.9	1.3	-0.9	0.9	0.8	-1.2
Reaction time trials on left	0.6	0.9	1.4	-0.9	0.9	0.8	-1.2
Reaction time mean	0.1	0.1	0.4	-0.3	0.3	0.0	-0.7
Reaction time mean AUC	0.2	0.2	0.6	-0.4	0.4	0.2	-0.8
Median of all reaction times	0.2	0.3	0.9	-0.3	0.3	-0.1	-1.0
Reaction time omissions	0.7	0.9	1.5	-0.9	0.9	0.8	-1.2
Reaction time false alarm rate	0.0	0.0	0.0	0.2	-0.2	-0.1	0.1
Reaction time premature initiation rate	2.7	3.7	6.7	1.9	-1.9	-1.1	2.6
Reaction time premature initiations	0.9	1.3	2.4	1.1	-1.1	-0.5	1.6
Std. dev. reaction times	0.0	0.1	0.1	0.3	-0.3	-0.3	0.1
Reaction time trials completed	0.6	0.9	1.4	-0.9	0.9	0.8	-1.2
Reaction time trials AUC	0.4	0.6	1.0	-0.7	0.7	0.6	-1.0
Social response proportion	0.4	0.4	0.5	-0.6	0.6	0.7	-0.6
Social responses	0.1	0.2	0.3	-0.4	0.4	0.5	-0.3
Social time	0.3	0.4	0.8	0.6	-0.6	-0.9	0.3
Conditioned locomotion	0.7	0.8	0.9	1.0	-1.0	-0.8	0.8
Cocaine response after cond. corrected	1.8	2.0	2.2	1.5	-1.5	-1.4	1.4
Cocaine response after cond. not corrected	4.1	4.6	4.9	2.2	-2.2	-2.2	2.0
Cocaine response before conditioning	1.2	1.4	1.6	1.2	-1.2	-1.3	1.1
Saline control response	1.2	1.6	2.6	1.2	-1.2	-0.9	1.6
Condit. Reinf. active minus inactive responses	0.5	0.6	1.0	-0.8	0.8	1.0	-0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.5	0.5	0.5	-0.2
Condit. Reinf. active responses	0.1	0.2	0.4	-0.1	0.1	0.4	0.7
Condit. Reinf. inactive responses	0.4	0.5	0.9	0.6	-0.6	-0.5	1.0
Condit. Reinf. lever presses	0.8	1.1	2.1	0.9	-0.9	-0.7	1.5
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	-0.2	0.2	0.5	0.6
Pavlov. Cond. lever latency	1.2	1.7	2.0	-1.3	1.3	1.2	-1.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	0.6	-0.6	-0.5	0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.1	0.1	0.2	0.5
Pavlov. Cond. index score	0.8	1.0	1.5	0.9	-0.9	-0.9	1.2
Pavlov. Cond. latency score	1.2	1.5	2.0	1.2	-1.2	-1.1	1.4
Pavlov. Cond. lever contacts	1.2	1.7	1.9	1.3	-1.3	-1.3	1.4
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	-0.6	0.6	0.6	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.4	0.9	-0.9	-0.8	1.2
Pavlov. Cond. response bias	0.5	0.6	0.8	0.8	-0.8	-0.7	0.9
Conditioned reinforcement - actives	0.4	0.4	0.6	0.6	-0.6	-0.4	0.8
Conditioned reinforcement - inactives	0.5	0.6	0.6	0.8	-0.8	-0.8	0.7
Conditioned locomotion	3.5	4.2	5.0	2.1	-2.1	-1.8	2.2
Intermittent access intake day 1-15 change	0.8	0.8	0.8	0.9	-0.9	-0.9	0.9
Intermittent access intake escalation	1.1	1.1	1.3	1.1	-1.1	-1.0	1.1
Intermittent access intake escalation 2	2.6	2.5	3.8	1.6	-1.6	-1.2	2.0
Intermitt. access day 1 inactive lever presses	1.3	1.4	2.3	1.2	-1.2	-0.8	1.5
Intermitt. access day 15 inactive lever presses	4.7	5.2	5.3	2.3	-2.3	-2.3	2.2
Intermitt. access escalation Index	0.6	0.5	1.0	-0.7	0.7	0.4	-1.0
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.3	-0.3	-0.4	0.0
Intermittent access day 15 total infusions	0.3	0.3	0.4	0.6	-0.6	-0.6	0.5
Intermittent access terminal intake (last 3 days)	2.6	2.9	3.4	1.7	-1.7	-1.5	1.9
Intermittent access total infusions	0.3	0.4	0.4	0.6	-0.6	-0.6	0.6
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.3	-0.3	-0.4	0.2
Intermittent access day 15 total locomotion	0.5	0.5	0.6	0.7	-0.7	-0.8	0.6
Intermittent access total locomotion	0.8	0.9	1.2	1.0	-1.0	-1.1	0.7
Intermittent access standard deviation	1.0	1.1	1.5	1.0	-1.0	-1.2	0.7
Cocaine induced anxiety	4.0	4.6	5.2	2.2	-2.2	-2.3	1.9
Post-drug Anxiety	3.4	3.8	4.2	1.9	-1.9	-1.8	2.0
Baseline Anxiety	1.1	1.1	1.7	-1.1	1.1	1.3	-0.7
Lifetime Intake	0.4	0.4	0.6	0.6	-0.6	-0.8	0.5
Incentive Sensitization - Responses	0.4	0.4	0.8	0.6	-0.6	-0.4	0.9
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	0.6	-0.6	-0.3	0.8
Progressive ratio test 1 active lever presses	0.4	0.4	0.9	0.6	-0.6	-0.9	0.2
Progressive ratio test 1 breakpoint	0.5	0.6	1.1	0.7	-0.7	-1.0	0.3
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.4	0.6	-0.6	-0.6	0.5
Progressive ratio test 2 active lever presses	0.5	0.5	0.6	0.7	-0.7	-0.7	0.7
Progressive ratio test 2 breakpoint	0.4	0.4	0.4	0.7	-0.7	-0.6	0.7
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.6	0.8	-0.8	-0.7	0.8
Total sessions with >9 infusions	0.5	0.6	0.7	0.7	-0.7	-0.9	0.6
Short access day 1 total inactive lever presses	4.8	5.4	6.3	2.4	-2.4	-2.5	1.9
Short access day 10 total inactive lever presses	9.2	10.1	14.1	3.1	-3.1	-2.6	3.8
Short access day 1 total infusions	0.8	0.9	1.4	0.9	-0.9	-1.2	0.6
Short access day 10 total infusions	1.3	1.4	1.8	1.2	-1.2	-1.4	0.9
Short access total infusions	0.6	0.7	1.1	0.8	-0.8	-1.1	0.5
Short access day 1 locomotion	0.8	0.9	1.3	1.0	-1.0	-1.1	0.7
Short access day 10 total locomotion	4.1	4.5	5.0	2.2	-2.2	-2.2	1.9
Short access total locomotion	1.3	1.4	1.8	1.2	-1.2	-1.3	0.9
Compulsive drug intake	0.7	0.7	0.7	-0.9	0.9	0.9	-0.7
One hour access (0.3 mA shock)	0.3	0.3	0.9	0.5	-0.5	-0.2	0.9
One hour access (shock baseline)	0.9	1.0	1.8	1.0	-1.0	-0.7	1.3
Number of responses in last shaping day	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1
Context. condit. distance diff. score	1.8	2.2	2.5	1.5	-1.5	-1.6	1.3
Locomotion velocity, session 1	0.2	0.2	0.2	0.5	-0.5	-0.4	0.3
Locomotion distance, session 1	2.3	3.0	3.1	-1.7	1.7	1.7	-1.8
Locomotion velocity, session 2	1.0	1.2	1.3	1.1	-1.1	-0.9	1.1
Locomotion distance, session 2	0.9	1.4	1.4	-1.2	1.2	1.2	-1.1
Locomotion velocity, session 3	0.5	0.5	1.1	0.7	-0.7	-1.1	0.1
Locomotion distance, session 3	0.1	0.1	0.2	-0.1	0.1	-0.0	-0.5
Stereotopy head waving bouts, day 3	2.0	2.4	2.8	-1.6	1.6	1.7	-1.3
Stereotopy head waving duration, day 3	0.8	0.9	1.0	-1.0	1.0	0.9	-1.0
Locomotion velocity, session 7	0.5	0.6	0.9	0.8	-0.8	-0.9	0.4
Locomotion distance, session 7	0.2	0.2	0.3	0.4	-0.4	-0.6	0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.3	0.3	0.4	-0.3
Stereotopy head waving duration, day 7	0.4	0.5	0.8	-0.7	0.7	0.6	-0.9
Locomotion velocity, session 8	1.8	2.1	2.4	1.6	-1.6	-1.4	1.2
Locomotion distance, session 8	0.7	1.0	1.3	1.0	-1.0	-0.9	1.1
Degree of sensitization distance	1.3	1.3	2.1	1.1	-1.1	-0.9	1.4
Degree of sensitization stereotypy	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
Condit. Reinf. active minus inactive responses	1.4	1.5	1.9	1.3	-1.3	-0.9	1.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.5	-0.5	-0.4	0.4
Condit. Reinf. active responses	2.3	2.8	3.4	1.7	-1.7	-1.3	1.8
Condit. Reinf. inactive responses	1.5	1.8	2.2	1.4	-1.4	-1.1	1.5
Incentive salience index mean	2.1	2.6	3.7	1.6	-1.6	-1.1	1.9
Condit. Reinf. lever presses	1.9	2.5	3.9	1.6	-1.6	-1.1	2.0
Time in familiar zone, hab. session 1	0.5	0.5	0.9	0.7	-0.7	-1.0	0.3
Time in novel zone, hab. session 1	0.7	0.7	1.1	-0.8	0.8	1.1	-0.6
Total zone transitions, hab. session 1	2.9	4.1	4.5	-2.1	2.1	2.0	-1.8
Total locomotion distance, hab. session 1	0.2	0.2	0.4	-0.5	0.5	0.6	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.7	0.7	0.8	-0.2
Time in familiar zone, hab. session 2	2.0	2.1	2.9	1.5	-1.5	-1.7	1.0
Time in novel zone, hab. session 2	1.9	2.0	2.2	-1.4	1.4	1.5	-1.3
Total zone transitions, hab. session 2	0.0	0.1	0.2	0.2	-0.2	-0.4	0.1
Total locomotion distance, hab. session 2	0.9	1.2	1.3	1.1	-1.1	-1.1	1.2
Locomotion velocity, hab. session 2	0.8	1.0	1.3	1.0	-1.0	-1.0	1.2
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.1	0.1	-0.1	-0.6
Novelty place preference	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.4
Time in novel zone, NPP test	0.1	0.1	0.3	0.1	-0.1	-0.3	-0.5
Total zone transitions, NPP test	0.7	1.1	1.2	-1.1	1.1	0.9	-1.0
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.0	0.0	0.2	0.2
Locomotion velocity, NPP test	0.0	0.0	0.1	0.1	-0.1	0.1	0.3
Pavlov. Cond. lever latency	1.0	1.3	1.7	-1.1	1.1	0.9	-1.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.6	0.6	0.5	-0.7
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	0.0	0.3	0.1
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	-0.1	-0.0	0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.4	-0.4	-0.2	0.5
Pavlov. Cond. lever contacts	1.6	1.9	2.4	1.4	-1.4	-1.1	1.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	0.5	-0.5	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.1	1.2	-1.2	-0.9	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	-0.0	0.1	0.1
Pavlov. Cond. response bias	0.2	0.2	0.2	0.5	-0.5	-0.3	0.4
Bone: apparent density	0.6	1.0	1.3	-0.9	0.9	1.1	-0.9
Bone surface	0.6	1.0	1.9	-1.0	1.0	1.4	-0.6
Bone volume	1.0	1.6	2.5	-1.3	1.3	1.6	-0.9
Bone: connectivity density	0.2	0.4	0.5	-0.5	0.5	0.7	-0.7
Bone: cortical apparent density	2.8	3.7	4.7	-1.9	1.9	1.6	-2.2
Bone: cortical area	0.1	0.2	0.6	0.2	-0.2	0.1	0.7
Bone: cortical porosity	0.3	0.3	0.8	0.4	-0.4	-0.0	0.9
Bone: cortical porosity	0.9	1.0	2.0	0.9	-0.9	-0.5	1.4
Bone: cortical thickness	0.1	0.2	0.3	-0.5	0.5	0.5	-0.2
Bone: cortical thickness	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.0
Bone: cortical tissue density	2.6	3.4	4.3	-1.8	1.8	1.5	-2.1
Bone: elastic displacement	0.1	0.1	0.1	-0.2	0.2	0.2	-0.4
Bone: elastic work	0.3	0.4	0.6	0.6	-0.6	-0.5	0.8
Bone: endosteal estimation	0.1	0.2	0.6	0.4	-0.4	-0.1	0.8
Bone: endosteal perimeter	0.3	0.7	2.1	0.5	-0.5	0.3	1.4
Bone: final force	0.2	0.4	0.4	-0.6	0.6	0.7	-0.4
Bone: final moment	0.3	0.5	0.5	-0.7	0.7	0.7	-0.6
Bone: marrow area	0.1	0.1	0.4	0.3	-0.3	-0.0	0.6
Bone: maximum diameter	0.7	1.2	2.1	1.0	-1.0	-0.7	1.5
Bone: maximum force	0.1	0.1	0.1	-0.3	0.3	0.4	-0.1
Bone: maximum moment	0.1	0.1	0.2	-0.4	0.4	0.3	-0.3
Bone: minimum diameter	0.1	0.2	0.5	0.3	-0.3	0.0	0.7
Bone: periosteal estimation	0.2	0.3	0.9	0.4	-0.4	-0.0	1.0
Bone: periosteal perimeter	0.4	0.7	2.0	0.6	-0.6	-0.0	1.4
Bone: post-yield work	0.9	1.2	1.7	-1.1	1.1	0.8	-1.3
Bone: stiffness	0.3	0.5	0.6	-0.8	0.8	0.7	-0.6
Bone: tissue strength	0.5	0.5	0.7	-0.7	0.7	0.5	-0.9
Bone: trabecular number	0.3	0.4	0.6	-0.6	0.6	0.8	-0.7
Bone: trabecular spacing	1.6	2.0	2.1	1.4	-1.4	-1.5	1.4
Bone: trabecular thickness	0.1	0.1	0.3	-0.3	0.3	0.5	0.1
Bone: trabecular tissue density	2.7	3.8	4.1	-2.0	2.0	1.9	-1.9
Breakpoint value in progressive ratio session	1.0	1.1	1.5	1.0	-1.0	-0.9	1.2
Distance traveled before self-admin	1.3	1.4	1.8	-1.2	1.2	1.0	-1.4
Distance traveled after self-admin	0.1	0.2	0.3	0.4	-0.4	-0.6	-0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.3	-0.3	-0.6	0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.2	0.2	0.4	0.0
Diff in mean of infusions in LGA sessions	2.0	2.3	2.5	1.5	-1.5	-1.4	1.6
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.2	0.2	0.3	0.2
Active lever presses in extinction session 6	2.5	2.4	2.4	1.5	-1.5	-1.5	1.5
Delta distance traveled before/after self-admin	4.1	4.4	4.8	2.2	-2.2	-2.2	1.8
Delta ambulatory time before/after self-admin	2.2	2.4	2.7	1.6	-1.6	-1.6	1.3
Time in closed arm before self-admin	0.9	1.0	2.1	-0.9	0.9	1.5	-0.4
Time in closed arm after self-admin	0.1	0.1	0.2	-0.1	0.1	0.4	0.4
Time in open arm before self-admin	0.1	0.1	0.2	0.1	-0.1	-0.4	-0.2
Time in open arm after self-admin	0.0	0.0	0.0	0.1	-0.1	-0.2	0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.3	0.6	-0.6	-0.5	0.5
Time to tail flick, vehicle, before self-admin	1.3	1.3	2.0	1.1	-1.1	-0.8	1.4
Time to tail flick, vehicle, after self-admin	1.1	1.1	1.9	1.1	-1.1	-0.7	1.4
Time to tail flick, test, before self-admin	0.9	0.9	1.0	1.0	-1.0	-0.9	1.0
Time to tail flick, test, after self-admin	2.3	2.4	2.7	1.6	-1.6	-1.3	1.7
Delta time to tail flick, vehicle, before/after SA	0.8	0.7	0.8	-0.9	0.9	0.8	-0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.2	-0.2	-0.2	0.2
Ambulatory time before self-admin	0.3	0.3	0.7	-0.4	0.4	0.1	-0.8
Ambulatory time after self-admin	0.4	0.4	0.8	0.7	-0.7	-0.9	0.2
Total heroin consumption	0.2	0.3	0.3	0.5	-0.5	-0.6	0.6
Area under the delay curve	1.7	1.9	2.2	-1.4	1.4	1.5	-1.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.8	0.2	-0.2	0.2	0.9
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	-0.6	0.6	0.9	-0.2
Delay disc. indifference point, 2s delay	3.2	3.5	5.0	-2.0	2.0	2.2	-1.2
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.6	-0.6	-0.6	0.5
Delay disc. indifference point, 4s delay	1.5	1.6	2.0	-1.4	1.4	1.4	-0.8
Delay disc. indifference point, 8s delay	1.9	2.0	2.3	-1.5	1.5	1.3	-1.4
Delay discount exponential model param	1.5	1.6	1.8	1.3	-1.3	-1.3	1.1
Delay discount hyperbolic model param	1.7	1.8	2.0	1.4	-1.4	-1.4	1.0
Fecal boli incidents, locomotor time 1	0.4	0.4	0.7	-0.6	0.6	0.4	-0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.4	-0.4	-0.3	0.7
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.3	0.7	-0.7	-0.3	1.1
Bouts of movement, locomotor time 1	0.3	0.4	0.5	0.7	-0.7	-0.6	0.4
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.3	-0.3	-0.2	-0.0
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	-0.2	-0.5	-0.4
Distance moved, locomotor task time 1	0.4	0.4	1.0	0.5	-0.5	-0.3	1.0
Vertical activity count, locomotor time 1	1.2	1.2	2.4	1.0	-1.0	-0.6	1.5
Time >=10cm from walls, locomotor time 2	2.3	2.4	3.7	1.5	-1.5	-1.2	1.9
Bouts of movement, locomotor time 2	0.3	0.3	0.5	-0.5	0.5	0.7	-0.7
Total resting periods, locomotor time 2	0.4	0.5	0.6	-0.6	0.6	0.8	-0.8
Rest time, locomotor task time 2	0.8	1.0	2.2	-0.8	0.8	0.5	-1.5
Distance moved, locomotor task time 2	2.0	2.3	3.7	1.4	-1.4	-1.1	1.9
Vertical activity count, locomotor time 2	2.7	3.0	4.6	1.7	-1.7	-1.3	2.1
Weight adjusted by age	4.0	4.5	6.7	2.1	-2.1	-1.7	2.6
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.7	-0.8	0.8	0.8	-0.8
Locomotion in novel chamber	0.6	0.7	0.9	1.0	-1.0	-1.0	0.4
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.1	0.1	0.4	0.1
Progressive ratio	0.4	0.5	0.7	0.7	-0.7	-0.8	0.5
Food seeking constrained by brief footshock	3.0	3.7	4.2	1.9	-1.9	-1.9	2.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.0	0.0	0.1	0.3
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.0	-0.0	-0.2	-0.2
Run reversals in cocaine runway, males	1.1	1.1	1.1	-1.1	1.1	0.9	-1.1
Latency to leave start box in cocaine runway	1.8	2.0	2.1	1.5	-1.5	-1.4	1.3
Latency to leave start box in cocaine runway, F	2.3	2.5	3.2	1.7	-1.7	-1.8	1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	0.1	0.2	0.2
Cd content in liver	0.5	0.5	0.6	-0.8	0.8	0.6	-0.7
Co content in liver	0.6	0.7	0.9	0.8	-0.8	-0.6	1.0
Cu content in liver	2.0	2.4	5.1	-1.4	1.4	0.7	-2.2
Fe content in liver	0.0	0.1	0.1	-0.3	0.3	0.3	-0.1
K content in liver	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.1
Mg content in liver	0.3	0.3	0.4	-0.4	0.4	0.7	-0.5
Mn content in liver	0.0	0.0	0.1	0.3	-0.3	-0.0	0.2
Na content in liver	5.4	5.7	7.4	-2.4	2.4	2.7	-2.0
Rb content in liver	0.4	0.5	0.5	-0.7	0.7	0.7	-0.7
Se content in liver	1.3	1.6	2.0	1.3	-1.3	-1.4	0.9
Sr content in liver	1.4	1.2	2.2	-1.1	1.1	0.7	-1.5
Zn content in liver	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.3