Hub : Genes

ENSRNOG00000066171

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	ENSRNOT00000111726	0.44	0.29	0.0e+00	0.33	0.22	0.35	0.19	1.1e-37	4.8e-24	1.1e-39	6.9e-21
2	Adipose	isoform ratio	ENSRNOT00000114599	0.09	0.06	1.3e-07	0.05	0.02	0.04	-0	3.2e-06	5.7e-03	4.8e-05	4.0e-01
3	Brain	isoform ratio	ENSRNOT00000099733	0.05	0.06	2.2e-03	0.03	0.02	0.03	0.02	2.1e-03	5.4e-03	2.1e-03	4.7e-03
4	Brain	intron excision ratio	chr6:27482426:27483205	0.02	0.02	6.5e-03	0.03	0.02	0.02	0.02	2.0e-03	8.8e-03	9.2e-03	5.3e-03
5	LHb	isoform ratio	ENSRNOT00000099733	0.13	0.11	3.4e-03	0.1	0.09	0.09	0.1	1.8e-03	3.8e-03	4.6e-03	2.8e-03
6	NAcc	isoform ratio	ENSRNOT00000099733	0.06	0.06	1.3e-03	0.01	0.02	0.01	0.01	5.6e-02	1.2e-02	2.6e-02	8.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	3.5	11.4	13.8	3.1	-3.2	-3.4	-3.7	-3.2	-3.6
BMI without tail	1.6	3.3	5.1	1.6	-1.9	-2.3	-1.6	-1.7	-1.7
Body weight	3.5	14.8	16.8	3.5	-3.6	-4.0	-4.1	-3.9	-4.0
Epididymis fat weight	20.9	48.8	57.1	6.9	-6.7	-6.4	-7.3	-7.1	-7.6
Glucose	0.2	0.3	0.6	0.7	-0.8	-0.6	-0.2	-0.6	-0.5
Heart weight	3.7	5.2	6.7	2.0	-2.1	-2.4	-2.3	-2.3	-2.6
Left kidney weight	0.1	0.2	0.4	-0.6	0.4	0.0	0.6	0.2	0.4
Right kidney weight	0.6	1.6	2.1	1.2	-1.3	-1.3	-1.0	-1.4	-1.5
Tail length	0.1	0.3	0.6	-0.6	0.3	0.2	0.7	0.3	0.8
Length with tail	0.2	0.8	1.6	0.5	-0.8	-1.3	-0.9	-1.1	-0.8
Length without tail	0.2	0.3	0.7	0.3	-0.2	-0.5	-0.8	-0.7	-0.6
Liver weight, left	2.1	3.4	6.9	1.4	-1.9	-2.6	-1.4	-1.7	-1.7
Liver weight, right	5.0	8.2	9.6	2.7	-2.7	-2.9	-2.9	-3.1	-2.9
Parametrial fat weight	16.0	31.2	41.0	5.0	-5.6	-6.4	-5.2	-5.5	-5.8
Retroperitoneal fat weight	35.6	117.6	138.9	10.2	-10.8	-11.0	-10.6	-10.7	-11.8
Intraocular pressure	2.5	3.6	5.6	1.9	-1.9	-1.6	-1.6	-1.8	-2.4
Extensor digitorum longus weight	1.6	6.5	8.3	-2.4	2.5	2.4	2.6	2.4	2.9
Soleus weight	3.5	10.1	13.1	-3.0	3.1	3.2	3.0	3.1	3.6
Tibialis anterior weight	0.9	3.2	4.4	-1.5	1.7	1.9	1.8	1.7	2.1
Tibia length	0.9	2.6	4.3	1.3	-1.6	-2.1	-1.3	-1.8	-1.6
Number of licking bursts	2.3	2.8	3.3	1.5	-1.6	-1.7	-1.7	-1.8	-1.5
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.1	0.1	0.2	0.1	-0.0	0.4
Times rat made contact with spout	1.3	1.5	2.7	-0.9	1.3	1.6	0.7	1.2	1.3
Mean time between licks in bursts	1.5	2.1	3.1	1.8	-1.5	-0.9	-1.5	-1.5	-1.3
Mean num. licks in bursts	4.0	4.8	6.4	-1.9	2.2	2.5	2.0	2.4	2.1
Std. dev. time between licks in bursts	0.1	0.2	0.3	0.5	-0.3	-0.1	-0.5	-0.6	-0.3
Water consumed over 24 hours	0.4	0.5	1.3	-0.3	0.7	1.1	0.3	0.5	0.9
Indifference point 0 sec	0.1	0.1	0.2	0.4	-0.2	0.5	-0.2	-0.3	-0.3
Indifference point AUC	0.0	0.0	0.1	0.3	-0.2	0.2	0.0	-0.1	0.2
Indifference point function ln k	1.6	2.3	3.1	-1.8	1.6	1.3	1.4	1.5	1.6
Indifference point function log k	1.6	2.3	3.1	-1.8	1.6	1.3	1.4	1.5	1.6
Delay discounting total patch changes 0 sec	0.0	0.1	0.4	0.2	-0.1	0.6	-0.0	-0.2	-0.1
Delay discounting total patch changes 12 sec	1.3	1.7	2.4	1.5	-1.4	-0.9	-1.1	-1.5	-1.3
Delay discounting total patch changes 18 sec	0.3	0.4	0.9	0.9	-0.6	0.6	-0.2	-0.5	-0.4
Delay discounting total patch changes 24 sec	0.7	0.9	1.1	1.0	-1.1	-0.7	-0.9	-1.0	-0.8
Delay discounting total patch changes 6 sec	0.9	1.3	2.1	1.4	-1.3	-0.5	-1.1	-1.3	-1.1
Delay discounting time to switch 0 sec	0.5	0.7	1.4	0.8	-0.9	-0.9	-0.5	-0.7	-1.2
Delay discounting water rate 0 sec	2.6	4.1	5.4	-2.0	2.0	2.1	1.8	1.9	2.3
Delay discounting water rate 12 sec	0.1	0.2	0.8	-0.2	-0.2	-0.9	-0.1	-0.2	-0.1
Delay discounting water rate 18 sec	2.5	3.3	4.8	-2.2	1.8	1.1	1.9	1.7	2.0
Delay discounting water rate 24 sec	0.0	0.0	0.1	0.1	-0.0	0.0	-0.3	-0.1	-0.2
Delay discounting water rate 6 sec	0.7	0.9	1.5	-1.2	0.8	0.3	1.1	1.0	1.1
Locomotor activity	3.1	4.9	5.5	2.0	-2.3	-2.4	-2.2	-2.3	-2.1
Locomotor testing distance	2.5	4.1	5.2	2.0	-2.3	-2.0	-1.8	-2.1	-1.8
Locomotor testing rearing	0.2	0.4	0.6	0.5	-0.7	-0.8	-0.5	-0.6	-0.4
Light reinforcement 1	0.1	0.2	0.7	-0.5	-0.0	-0.0	0.9	0.3	0.7
Light reinforcement 2	2.4	3.2	4.2	-2.0	1.7	1.4	2.1	1.7	1.8
Reaction time number correct	0.2	0.3	0.5	-0.6	0.6	0.6	0.3	0.4	0.7
Reaction time mean minus median	1.8	2.3	2.8	1.6	-1.7	-1.6	-1.3	-1.5	-1.6
Reaction time mean minus median AUC	2.0	2.6	3.2	1.6	-1.8	-1.8	-1.4	-1.6	-1.5
Reaction time num false alarms	2.7	3.8	4.8	2.1	-2.0	-1.5	-2.0	-2.2	-1.8
Reaction time num false alarms AUC	2.5	3.6	4.7	2.0	-1.9	-1.6	-1.9	-2.2	-1.7
Reaction time trials correct on left	0.2	0.3	0.5	-0.6	0.6	0.6	0.3	0.4	0.7
Reaction time trials on left	0.1	0.2	0.4	-0.5	0.5	0.5	0.1	0.3	0.6
Reaction time mean	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.4	-0.4	-0.6
Reaction time mean AUC	0.1	0.2	0.3	0.4	-0.4	-0.6	-0.3	-0.4	-0.5
Median of all reaction times	0.0	0.0	0.1	-0.2	0.2	0.1	0.2	0.3	0.1
Reaction time omissions	1.7	2.3	3.1	1.7	-1.6	-1.2	-1.7	-1.8	-1.0
Reaction time false alarm rate	2.8	3.9	4.4	2.0	-2.0	-1.9	-1.9	-2.1	-2.0
Reaction time premature initiation rate	0.1	0.1	0.4	-0.1	0.4	0.6	0.2	0.1	0.2
Reaction time premature initiations	0.3	0.4	0.9	-0.5	0.7	1.0	0.5	0.4	0.7
Std. dev. reaction times	1.8	2.5	3.0	1.6	-1.7	-1.6	-1.4	-1.6	-1.6
Reaction time trials completed	0.1	0.2	0.4	-0.5	0.5	0.5	0.1	0.3	0.6
Reaction time trials AUC	0.1	0.2	0.3	-0.5	0.4	0.4	0.1	0.2	0.6
Social response proportion	0.1	0.1	0.3	-0.5	0.3	-0.3	0.2	0.5	-0.3
Social responses	0.4	0.6	0.7	0.7	-0.8	-0.7	-0.6	-0.7	-0.8
Social time	0.1	0.1	0.3	-0.5	0.3	-0.5	0.2	0.2	-0.2
Conditioned locomotion	1.9	2.3	3.3	-1.1	1.4	1.8	1.3	1.5	1.8
Cocaine response after cond. corrected	0.0	0.1	0.2	-0.2	-0.1	-0.5	0.1	0.1	0.1
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.7	0.3	-0.1	0.7	0.4	0.5
Cocaine response before conditioning	1.4	1.7	2.1	-1.3	1.4	1.2	1.4	1.1	1.3
Saline control response	1.7	2.3	2.5	-1.5	1.5	1.5	1.5	1.6	1.6
Condit. Reinf. active minus inactive responses	0.5	0.7	1.6	-0.6	0.6	0.7	1.2	0.6	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.1	0.0	0.4	-0.1	0.3
Condit. Reinf. active responses	0.2	0.3	1.0	-0.5	0.3	0.1	1.0	0.3	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.2	0.1	-0.1	0.5	0.1	0.4
Condit. Reinf. lever presses	0.6	0.8	1.5	-0.9	0.7	0.6	1.2	0.9	0.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.9	-0.5	0.3	0.0	0.9	0.3	0.5
Pavlov. Cond. lever latency	0.7	1.0	1.2	0.8	-1.0	-1.1	-1.0	-0.9	-1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.3	-0.0	0.4	0.3	0.0	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.0	0.3	0.4	0.4	0.3	0.3
Pavlov. Cond. index score	0.5	0.6	1.0	-0.5	0.8	1.0	0.9	0.8	0.8
Pavlov. Cond. latency score	0.6	0.7	1.2	-0.6	0.8	1.1	1.0	0.8	0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.2	0.3	0.4	0.4	0.2	0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.6	0.3	-0.2	0.2	0.3	0.4
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.0	0.7	-1.1	-1.4	-1.4	-1.0	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.3	0.5	0.8	0.7	0.5	0.5
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.3	0.5	0.8	0.6	0.4	0.7
Conditioned reinforcement - actives	3.7	3.7	4.1	-2.0	1.8	1.7	2.0	2.0	1.9
Conditioned reinforcement - inactives	5.7	6.4	7.7	-2.7	2.6	2.1	2.5	2.5	2.8
Conditioned locomotion	5.0	6.0	8.6	-2.9	2.5	1.6	2.7	2.6	2.1
Intermittent access intake day 1-15 change	5.2	5.1	6.7	-2.2	1.9	2.2	2.5	2.6	2.2
Intermittent access intake escalation	3.9	3.9	5.3	-1.7	1.5	2.1	2.2	2.3	1.9
Intermittent access intake escalation 2	1.2	1.2	1.8	-0.7	0.8	1.4	1.2	1.4	0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.0	-0.3	-0.4	-0.4	-0.3	0.2
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.8	-0.4	0.4	0.7	0.3	0.3	0.9
Intermitt. access escalation Index	1.5	1.4	2.4	0.9	-1.3	-1.3	-1.0	-0.9	-1.6
Intermittent access day 1 total infusions	1.3	1.5	2.0	-1.4	1.4	0.9	1.1	1.0	1.4
Intermittent access day 15 total infusions	3.3	3.7	4.4	-2.0	1.8	1.6	2.1	2.0	2.0
Intermittent access terminal intake (last 3 days)	2.7	2.9	4.0	-2.0	1.7	1.3	1.8	1.7	1.7
Intermittent access total infusions	2.0	2.2	2.9	-1.7	1.5	1.0	1.6	1.4	1.5
Intermittent access day 1 locomotion	2.6	2.7	4.2	-2.0	1.8	0.9	1.7	1.5	1.6
Intermittent access day 15 total locomotion	0.7	0.7	1.1	-1.1	1.0	0.5	0.9	0.8	0.7
Intermittent access total locomotion	1.2	1.3	2.5	-1.6	1.3	0.4	1.2	1.1	1.0
Intermittent access standard deviation	0.6	0.6	1.0	-0.6	0.7	0.8	1.0	1.0	0.7
Cocaine induced anxiety	1.1	1.3	3.0	-0.7	1.0	1.7	1.0	1.1	1.0
Post-drug Anxiety	0.3	0.3	0.5	0.7	-0.7	0.1	-0.6	-0.5	-0.2
Baseline Anxiety	1.6	1.7	2.4	1.1	-1.4	-1.6	-1.3	-1.3	-1.1
Lifetime Intake	2.3	2.6	3.2	-1.8	1.6	1.2	1.8	1.6	1.7
Incentive Sensitization - Responses	2.7	2.7	3.2	-1.8	1.8	1.4	1.8	1.8	1.3
Incentive Sensitization - Breakpoint	2.1	2.1	2.6	-1.6	1.6	1.1	1.6	1.6	1.1
Progressive ratio test 1 active lever presses	0.6	0.6	1.0	-1.0	0.9	0.0	0.7	0.5	0.9
Progressive ratio test 1 breakpoint	0.5	0.5	1.1	-1.0	0.9	0.0	0.6	0.4	0.9
Progressive ratio test 1 inactive lever presses	1.6	1.7	2.4	-1.3	1.3	1.2	1.3	1.2	1.6
Progressive ratio test 2 active lever presses	2.4	2.5	3.0	-1.7	1.7	1.3	1.6	1.6	1.6
Progressive ratio test 2 breakpoint	2.6	2.9	3.5	-1.8	1.9	1.3	1.7	1.7	1.6
Progressive ratio test 2 inactive lever presses	3.8	4.4	4.8	-2.0	2.1	2.0	2.2	2.1	2.1
Total sessions with >9 infusions	3.0	3.2	5.1	-2.3	1.7	0.8	1.9	1.7	2.0
Short access day 1 total inactive lever presses	1.7	1.8	2.8	-1.5	1.4	1.0	1.3	1.2	1.7
Short access day 10 total inactive lever presses	0.9	1.0	1.9	1.4	-1.1	-0.2	-1.2	-1.2	-0.4
Short access day 1 total infusions	1.8	1.9	3.0	-1.4	1.2	1.0	1.7	1.5	1.3
Short access day 10 total infusions	2.8	3.0	3.9	-1.8	1.9	1.4	2.0	1.7	1.7
Short access total infusions	1.8	2.0	2.6	-1.5	1.5	1.1	1.6	1.3	1.5
Short access day 1 locomotion	1.9	2.0	3.0	-1.7	1.4	0.9	1.5	1.3	1.5
Short access day 10 total locomotion	1.5	1.6	2.0	-1.4	1.3	0.9	1.3	1.3	1.3
Short access total locomotion	2.8	2.8	4.4	-2.1	1.9	1.0	1.7	1.5	1.7
Compulsive drug intake	0.5	0.5	1.0	1.0	-0.6	-0.2	-0.6	-0.5	-0.9
One hour access (0.3 mA shock)	4.7	5.5	7.0	-2.0	2.0	2.4	2.6	2.6	2.2
One hour access (shock baseline)	3.7	4.3	5.6	-2.1	1.8	1.8	2.4	2.3	2.0
Number of responses in last shaping day	1.5	1.6	2.3	-1.2	1.1	1.1	1.5	1.3	1.2
Context. condit. distance diff. score	0.4	0.5	1.4	-0.3	0.7	1.2	0.3	0.7	0.7
Locomotion velocity, session 1	0.3	0.3	0.5	0.6	-0.7	-0.4	-0.4	-0.6	-0.5
Locomotion distance, session 1	0.4	0.5	1.0	-0.6	0.6	0.6	0.8	0.5	1.0
Locomotion velocity, session 2	0.4	0.5	1.2	0.6	-0.4	-0.4	-1.1	-0.6	-0.7
Locomotion distance, session 2	0.0	0.0	0.1	-0.1	0.0	-0.2	-0.1	-0.2	0.1
Locomotion velocity, session 3	0.0	0.0	0.1	0.2	-0.1	0.3	-0.0	-0.1	0.0
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.1	0.1
Stereotopy head waving bouts, day 3	3.3	4.0	6.8	-1.4	1.8	2.6	2.1	2.0	1.9
Stereotopy head waving duration, day 3	0.6	0.7	1.4	-0.5	0.7	1.2	1.0	0.9	0.7
Locomotion velocity, session 7	0.1	0.1	0.2	0.0	0.3	0.2	-0.4	-0.1	0.0
Locomotion distance, session 7	0.5	0.6	0.8	0.9	-0.6	-0.5	-0.9	-0.9	-0.9
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.1	0.1	0.0
Stereotopy head waving duration, day 7	0.2	0.2	0.3	-0.4	0.3	0.4	0.5	0.5	0.5
Locomotion velocity, session 8	0.8	0.9	2.5	-0.5	1.0	1.6	0.5	0.9	0.9
Locomotion distance, session 8	1.4	2.1	3.0	-1.2	1.6	1.7	1.2	1.4	1.6
Degree of sensitization distance	1.0	1.0	1.4	1.2	-1.0	-0.8	-1.0	-1.1	-1.1
Degree of sensitization stereotypy	0.6	0.7	1.3	0.4	-0.8	-1.1	-0.9	-0.7	-0.7
Condit. Reinf. active minus inactive responses	3.3	3.7	4.8	1.7	-1.9	-2.2	-1.7	-1.9	-2.0
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.7	1.7	-1.8	-1.7	-1.3	-1.5	-1.9
Condit. Reinf. active responses	0.5	0.6	0.9	0.7	-0.7	-1.0	-0.7	-0.9	-0.7
Condit. Reinf. inactive responses	1.3	1.6	2.4	-1.2	1.4	1.2	1.1	1.0	1.5
Incentive salience index mean	1.3	1.6	2.1	1.1	-1.2	-1.5	-1.1	-1.4	-1.2
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.3	0.2	-0.1	0.2	-0.0	0.5
Time in familiar zone, hab. session 1	1.5	1.4	2.1	1.0	-1.0	-1.3	-1.4	-1.0	-1.3
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.6	-0.4	0.1	-0.4	-0.4	-0.5
Total zone transitions, hab. session 1	0.3	0.4	0.9	-0.5	0.7	0.6	0.7	0.4	0.9
Total locomotion distance, hab. session 1	0.7	1.0	1.6	-1.0	0.9	0.8	1.1	1.0	1.3
Locomotion velocity, hab. session 1	1.5	2.2	3.0	-1.6	1.4	1.1	1.6	1.4	1.7
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.2	-0.2	-0.1	-0.3	-0.1	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.6	-0.4	-0.1	-0.6	-0.5	-0.5
Total zone transitions, hab. session 2	0.0	0.1	0.2	-0.0	0.2	0.4	-0.0	-0.0	0.4
Total locomotion distance, hab. session 2	0.0	0.1	0.2	0.2	-0.0	0.4	-0.2	-0.1	0.3
Locomotion velocity, hab. session 2	0.0	0.1	0.2	0.2	-0.0	0.4	-0.1	-0.1	0.4
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	0.2	0.1
Novelty place preference	0.1	0.1	0.2	0.2	-0.3	-0.4	-0.4	-0.1	-0.2
Time in novel zone, NPP test	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.5	-0.1	-0.3
Total zone transitions, NPP test	0.3	0.5	1.1	-0.4	0.6	0.9	0.5	0.3	1.0
Total locomotion distance, NPP test	1.0	1.4	2.2	-0.9	1.2	1.5	1.1	1.0	1.5
Locomotion velocity, NPP test	1.3	1.8	3.1	-1.1	1.1	1.4	1.5	1.1	1.8
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.1	-0.3	-0.3	-0.2	-0.2	-0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.6	-0.4	-0.1	-0.6	-0.5	-0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.3	0.4	0.1	-0.0	0.2	0.3
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.1	0.2	-0.4	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.1	0.2	0.2	0.1	0.3	-0.4	-0.1	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.2	0.3	0.3	0.1	0.2	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.2	0.0	-0.3	0.3	0.1	-0.3
Pavlov. Cond. intertrial magazine entries	1.1	1.4	1.6	-1.1	1.2	1.2	1.1	1.3	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.3	0.5	0.6	0.1	0.3	0.7
Pavlov. Cond. response bias	0.5	0.6	1.2	-0.5	0.8	1.0	0.6	0.6	1.1
Bone: apparent density	3.6	5.9	9.2	-1.8	2.3	3.0	2.3	2.2	2.8
Bone surface	1.1	1.9	2.9	-1.2	1.5	1.7	1.0	1.2	1.5
Bone volume	2.4	4.1	5.8	-1.7	2.1	2.4	1.7	1.9	2.3
Bone: connectivity density	2.1	3.3	5.2	-1.4	1.7	2.3	1.7	1.7	2.0
Bone: cortical apparent density	0.1	0.1	0.3	-0.4	0.2	0.0	0.6	0.6	0.2
Bone: cortical area	0.1	0.2	0.4	0.3	-0.4	-0.7	-0.4	-0.6	-0.3
Bone: cortical porosity	2.0	2.2	2.7	-1.5	1.6	1.3	1.4	1.3	1.6
Bone: cortical porosity	1.5	1.6	2.0	-1.3	1.4	1.1	1.1	1.2	1.4
Bone: cortical thickness	0.3	0.6	1.8	0.2	-0.7	-1.3	-0.4	-0.7	-0.7
Bone: cortical thickness	0.6	0.7	0.9	-0.9	0.9	0.6	0.9	0.9	0.9
Bone: cortical tissue density	0.1	0.1	0.2	-0.3	0.1	-0.0	0.4	0.5	0.1
Bone: elastic displacement	1.7	2.0	3.3	-1.3	1.2	1.2	1.8	1.4	1.5
Bone: elastic work	1.2	1.5	2.1	-1.2	1.1	1.0	1.5	1.2	1.2
Bone: endosteal estimation	0.2	0.5	1.3	-0.4	0.7	1.2	0.4	0.5	0.8
Bone: endosteal perimeter	0.0	0.1	0.2	0.4	-0.2	0.2	-0.4	-0.4	-0.1
Bone: final force	0.2	0.3	0.5	0.3	-0.4	-0.6	-0.5	-0.7	-0.4
Bone: final moment	0.1	0.1	0.4	0.2	-0.3	-0.4	-0.4	-0.6	-0.3
Bone: marrow area	0.2	0.5	1.3	-0.4	0.7	1.1	0.4	0.5	0.8
Bone: maximum diameter	0.0	0.0	0.2	-0.0	0.1	0.4	-0.0	-0.2	0.3
Bone: maximum force	0.1	0.1	0.4	0.2	-0.2	-0.3	-0.4	-0.6	-0.3
Bone: maximum moment	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.2	-0.4	-0.1
Bone: minimum diameter	1.1	2.1	2.8	1.2	-1.3	-1.5	-1.7	-1.6	-1.4
Bone: periosteal estimation	0.1	0.2	0.4	-0.3	0.5	0.6	0.2	0.2	0.6
Bone: periosteal perimeter	0.1	0.1	0.3	0.3	-0.3	-0.2	-0.3	-0.5	-0.1
Bone: post-yield work	1.1	1.4	2.7	-0.8	1.3	1.7	1.0	1.0	1.3
Bone: stiffness	0.2	0.3	0.5	0.3	-0.3	-0.4	-0.7	-0.7	-0.4
Bone: tissue strength	0.5	0.5	1.0	0.3	-0.6	-1.0	-0.6	-0.7	-0.7
Bone: trabecular number	3.5	5.5	7.5	-1.9	2.2	2.7	2.3	2.2	2.6
Bone: trabecular spacing	0.8	1.0	2.4	0.5	-0.9	-1.5	-0.8	-0.8	-1.1
Bone: trabecular thickness	0.3	0.3	1.4	0.2	0.2	1.2	0.3	0.3	0.5
Bone: trabecular tissue density	0.0	0.0	0.2	0.1	0.1	0.5	0.1	-0.0	0.1
Breakpoint value in progressive ratio session	2.1	2.3	2.9	-1.3	1.7	1.7	1.7	1.4	1.3
Distance traveled before self-admin	0.0	0.0	0.0	-0.1	0.1	0.1	0.2	-0.0	0.1
Distance traveled after self-admin	0.1	0.1	0.1	0.1	0.3	0.4	0.4	0.2	0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.6	-0.4	-0.0	-0.5	-0.6	-0.5
Delta time in open arm before/after self-admin	0.4	0.4	0.6	0.5	-0.8	-0.7	-0.6	-0.6	-0.3
Diff in mean of infusions in LGA sessions	0.3	0.3	0.5	0.6	-0.5	-0.3	-0.6	-0.7	-0.3
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.0	0.3	0.3	-0.1	-0.1	0.1
Active lever presses in extinction session 6	0.1	0.1	0.2	0.3	-0.2	0.1	-0.0	-0.3	0.5
Delta distance traveled before/after self-admin	0.8	0.8	1.3	1.1	-0.9	-0.6	-0.9	-0.9	-0.8
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.1	0.2	0.4	0.1	0.3	0.1
Time in closed arm before self-admin	0.0	0.0	0.0	0.1	0.1	0.2	0.1	0.0	0.1
Time in closed arm after self-admin	1.2	1.2	1.6	0.9	-1.0	-1.2	-1.2	-1.3	-1.0
Time in open arm before self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.0	-0.0	-0.2
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	0.3	0.4	0.6	0.5	0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.0	0.1	0.5	0.2	0.1	0.3
Time to tail flick, vehicle, before self-admin	2.3	2.3	2.9	1.3	-1.7	-1.7	-1.5	-1.6	-1.3
Time to tail flick, vehicle, after self-admin	8.1	8.6	10.0	3.0	-2.7	-2.6	-3.0	-3.2	-3.1
Time to tail flick, test, before self-admin	1.3	1.3	2.3	-1.5	1.2	0.6	0.9	1.2	1.2
Time to tail flick, test, after self-admin	0.9	0.9	1.6	-1.2	1.3	0.6	0.7	0.9	0.9
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.6	1.3	-0.8	-0.6	-1.0	-1.2	-1.2
Delta time to tail flick, test, before/after SA	2.3	2.1	2.9	-1.4	1.7	1.4	1.5	1.4	1.1
Ambulatory time before self-admin	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.0	-0.3	-0.1
Ambulatory time after self-admin	0.0	0.1	0.2	0.1	0.2	0.2	0.4	0.1	0.2
Total heroin consumption	4.3	5.1	6.8	-2.0	2.3	2.3	2.6	2.4	2.0
Area under the delay curve	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.3	0.0	-0.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.0	-0.6	-0.7	-0.3	-0.2	-0.4
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.2	0.0	0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	0.1	-0.2	0.1	0.4	-0.1
Delay disc. indifference point, 24s delay	2.2	2.2	3.0	-1.4	1.5	1.3	1.3	1.4	1.7
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.3	0.2	-0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.1	0.1
Delay discount exponential model param	0.0	0.0	0.1	0.2	-0.3	-0.1	0.2	-0.2	-0.1
Delay discount hyperbolic model param	0.0	0.0	0.1	0.3	-0.2	-0.0	0.2	-0.2	-0.1
Fecal boli incidents, locomotor time 1	4.0	4.4	4.9	-2.1	2.1	2.0	2.0	2.1	2.2
Change in fecal boli incidents, locomotor task	2.2	2.1	4.4	1.5	-1.2	-1.3	-1.2	-1.1	-2.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.9	-0.4	0.8	1.0	0.4	0.4	0.4
Bouts of movement, locomotor time 1	0.3	0.3	0.7	-0.6	0.3	0.6	0.3	0.6	0.8
Total resting periods, locomotor time 1	0.5	0.6	1.0	-0.7	0.5	1.0	0.5	0.8	1.0
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.5	0.2	0.6	0.7	0.6	0.6
Distance moved, locomotor task time 1	1.0	1.1	1.5	0.8	-0.6	-1.2	-1.2	-1.1	-1.1
Vertical activity count, locomotor time 1	0.1	0.1	0.4	-0.1	0.2	-0.6	-0.2	-0.2	-0.5
Time >=10cm from walls, locomotor time 2	1.9	2.0	3.0	-1.1	1.7	1.7	1.4	1.3	1.1
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.2	0.2	-0.0	-0.2	0.2	0.2
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	0.1	0.1	-0.2	0.2	0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	-0.3	0.4	0.1	0.1	0.3
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.3	0.3	-0.4	0.1	0.1	-0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.4	-0.5	0.5	0.2	0.5	0.6	0.2
Weight adjusted by age	1.4	1.6	1.8	1.3	-1.2	-1.2	-1.2	-1.3	-1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	0.7	-0.6	-0.4	-0.6	-0.5	-0.7
Locomotion in novel chamber	2.1	2.6	4.3	1.1	-1.5	-2.1	-1.7	-1.7	-1.5
Locomotion in novel chamber post-restriction	0.3	0.4	0.9	0.5	-0.5	-0.7	-0.5	-0.6	-0.9
Progressive ratio	0.1	0.1	0.4	0.3	-0.1	0.2	-0.6	-0.5	-0.2
Food seeking constrained by brief footshock	7.0	8.6	11.2	-2.7	3.0	3.3	2.6	2.6	3.3
Seeking ratio, punishment vs. effort	1.9	2.3	2.7	-1.4	1.5	1.4	1.6	1.6	1.6
Run reversals in cocaine runway, females	1.0	1.0	1.6	-0.7	0.7	1.3	1.2	1.1	0.9
Run reversals in cocaine runway, males	0.9	0.9	1.3	-1.1	0.8	0.4	1.1	0.9	1.2
Latency to leave start box in cocaine runway	0.5	0.6	2.2	0.1	0.7	1.5	0.6	0.3	0.5
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.6	0.0	0.5	-0.2	-0.3	-0.1
Latency to leave start box in cocaine runway, M	1.9	1.8	3.5	-0.8	1.3	1.9	1.4	1.2	1.3
Cd content in liver	0.0	0.0	0.1	0.0	0.1	0.3	-0.1	0.1	0.1
Co content in liver	2.2	2.6	3.6	-1.9	1.8	1.1	1.5	1.5	1.8
Cu content in liver	0.7	0.8	1.2	1.0	-0.8	-0.6	-1.1	-0.9	-0.9
Fe content in liver	0.6	0.8	1.5	-0.5	0.8	1.2	0.8	0.9	0.9
K content in liver	2.7	2.7	3.2	1.6	-1.6	-1.5	-1.6	-1.8	-1.7
Mg content in liver	1.1	1.1	1.5	1.1	-1.1	-0.9	-1.0	-1.1	-1.2
Mn content in liver	0.1	0.1	0.1	-0.4	0.2	-0.4	-0.1	0.1	-0.2
Na content in liver	2.5	2.7	3.9	-1.7	1.5	1.2	2.0	1.6	1.8
Rb content in liver	0.6	0.8	1.6	1.3	-1.0	-0.2	-0.6	-1.0	-0.8
Se content in liver	0.5	0.6	1.0	0.7	-0.7	-0.8	-0.9	-0.6	-1.0
Sr content in liver	0.0	0.0	0.1	-0.2	0.2	0.1	-0.3	0.2	0.0
Zn content in liver	5.9	6.5	7.5	2.3	-2.6	-2.7	-2.6	-2.6	-2.5