Hub : Genes

ENSRNOG00000065275

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000065275	0.04	0.03	2.3e-04	0.02	0.02	0.03	0.02	3.3e-03	4.3e-03	9.3e-04	4.3e-03
2	Brain	intron excision ratio	chr7:8389091:8390787	0.07	0.05	7.9e-03	0.02	0.02	0.01	0.01	3.3e-03	1.2e-02	1.2e-02	1.2e-02
3	Brain	intron excision ratio	chr7:8390487:8390787	0.08	0.06	4.4e-03	0.03	0.01	0.02	0.01	1.9e-03	2.7e-02	4.5e-03	1.3e-02
4	OFC	gene expression	ENSRNOG00000065275	0.1	0.08	9.3e-03	0.01	0.03	0.03	0.01	1.6e-01	6.6e-02	5.4e-02	1.6e-01
5	PL	gene expression	ENSRNOG00000065275	0.05	0.04	1.8e-03	0.02	0.02	0.01	0.02	5.5e-03	1.9e-02	2.8e-02	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	4.0	13.1	22.5	4.5	1.0	-1.0	4.7	4.5
BMI without tail	1.5	3.2	5.0	1.9	1.3	-1.3	2.2	2.0
Body weight	0.7	3.1	5.1	2.1	0.7	-0.7	2.3	2.2
Epididymis fat weight	0.2	0.5	0.7	-0.8	0.8	-0.8	-0.5	-0.7
Glucose	0.7	1.1	1.9	1.3	0.4	-0.4	1.4	1.2
Heart weight	0.4	0.6	0.9	-0.9	0.6	-0.6	-0.7	-0.9
Left kidney weight	0.2	0.6	1.5	0.0	-1.2	1.2	-0.4	0.0
Right kidney weight	0.9	2.6	4.5	-1.9	-0.8	0.8	-2.1	-1.9
Tail length	2.2	6.5	11.5	-3.4	0.6	-0.6	-3.2	-3.2
Length with tail	1.2	4.3	7.6	-2.6	-0.5	0.5	-2.8	-2.5
Length without tail	0.3	0.7	1.7	0.1	-1.3	1.3	-0.4	0.0
Liver weight, left	1.6	2.6	4.5	1.8	0.8	-0.8	2.1	1.9
Liver weight, right	1.1	1.8	3.1	1.8	0.0	-0.0	1.8	1.7
Parametrial fat weight	0.3	0.7	1.2	-1.1	0.4	-0.4	-1.0	-1.0
Retroperitoneal fat weight	0.4	1.3	1.6	1.0	1.1	-1.1	1.3	1.2
Intraocular pressure	0.8	1.1	2.5	-0.6	1.6	-1.6	-0.1	-0.6
Extensor digitorum longus weight	2.9	11.7	19.8	3.8	2.1	-2.1	4.4	3.9
Soleus weight	5.8	16.8	28.4	5.2	0.7	-0.7	5.3	5.3
Tibialis anterior weight	0.6	2.1	3.6	1.8	0.2	-0.2	1.9	1.8
Tibia length	0.6	1.7	3.1	-1.7	0.2	-0.2	-1.6	-1.7
Number of licking bursts	0.7	0.8	2.0	-0.2	1.4	-1.4	0.3	0.0
Food consumed during 24 hour testing period	0.3	0.4	0.6	0.7	0.2	-0.2	0.8	0.8
Times rat made contact with spout	0.3	0.3	0.7	0.2	0.8	-0.8	0.5	0.2
Mean time between licks in bursts	2.7	3.8	6.8	-2.6	0.5	-0.5	-2.4	-2.5
Mean num. licks in bursts	0.1	0.2	0.4	0.2	-0.6	0.6	0.1	0.1
Std. dev. time between licks in bursts	0.9	1.1	1.6	-0.7	-1.3	1.3	-1.1	-0.7
Water consumed over 24 hours	0.9	1.0	1.2	1.1	-1.1	1.1	0.7	1.0
Indifference point 0 sec	0.1	0.2	0.4	0.6	-0.2	0.2	0.5	0.6
Indifference point AUC	0.7	0.8	1.4	-1.2	0.1	-0.1	-1.1	-1.2
Indifference point function ln k	0.2	0.2	0.4	0.6	0.2	-0.2	0.6	0.6
Indifference point function log k	0.2	0.2	0.4	0.6	0.2	-0.2	0.6	0.6
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	0.5	0.0	-0.0	0.4	0.5
Delay discounting total patch changes 12 sec	0.4	0.5	0.9	0.4	1.0	-1.0	0.7	0.4
Delay discounting total patch changes 18 sec	0.6	0.8	1.4	-1.2	0.0	-0.0	-1.2	-1.1
Delay discounting total patch changes 24 sec	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.3	-0.3
Delay discounting total patch changes 6 sec	0.1	0.1	0.2	-0.5	-0.0	0.0	-0.5	-0.4
Delay discounting time to switch 0 sec	1.5	2.3	3.8	1.9	-1.1	1.1	1.6	1.7
Delay discounting water rate 0 sec	0.7	1.1	2.4	-0.7	1.5	-1.5	-0.2	-0.5
Delay discounting water rate 12 sec	1.2	1.8	3.1	0.7	1.8	-1.8	1.2	0.9
Delay discounting water rate 18 sec	2.6	3.4	7.6	-1.1	2.8	-2.8	-0.2	-0.8
Delay discounting water rate 24 sec	3.0	4.1	10.0	-0.3	3.2	-3.2	0.7	-0.1
Delay discounting water rate 6 sec	1.4	2.1	3.4	-1.3	1.9	-1.9	-0.6	-1.2
Locomotor activity	2.4	3.8	6.1	-2.0	-1.6	1.6	-2.5	-2.0
Locomotor testing distance	1.3	2.1	3.8	-1.6	-1.0	1.0	-1.9	-1.6
Locomotor testing rearing	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.2	-0.2
Light reinforcement 1	3.5	6.5	11.3	-3.2	-0.7	0.7	-3.4	-3.2
Light reinforcement 2	1.1	1.4	2.5	-1.5	-0.3	0.3	-1.6	-1.4
Reaction time number correct	0.8	1.1	2.1	0.5	1.5	-1.5	0.9	0.6
Reaction time mean minus median	0.5	0.7	1.4	-1.0	-0.3	0.3	-1.2	-0.8
Reaction time mean minus median AUC	0.9	1.1	2.6	0.3	-1.6	1.6	-0.3	0.4
Reaction time num false alarms	0.1	0.1	0.2	0.0	0.5	-0.5	0.2	0.0
Reaction time num false alarms AUC	0.3	0.4	0.9	0.0	0.9	-0.9	0.3	0.1
Reaction time trials correct on left	0.8	1.1	2.1	0.5	1.5	-1.5	0.9	0.6
Reaction time trials on left	0.7	1.0	1.9	0.5	1.4	-1.4	0.9	0.6
Reaction time mean	0.4	0.6	1.4	0.3	-1.2	1.2	-0.1	0.4
Reaction time mean AUC	0.4	0.6	1.3	0.4	-1.1	1.1	-0.0	0.5
Median of all reaction times	0.6	0.9	1.2	0.9	-1.1	1.1	0.5	0.9
Reaction time omissions	0.2	0.2	0.4	-0.5	-0.4	0.4	-0.7	-0.4
Reaction time false alarm rate	0.0	0.0	0.0	0.1	-0.2	0.2	0.1	0.1
Reaction time premature initiation rate	1.0	1.3	2.0	-1.4	0.9	-0.9	-1.1	-1.3
Reaction time premature initiations	1.3	1.9	3.1	-1.3	1.8	-1.8	-0.7	-1.1
Std. dev. reaction times	0.3	0.4	0.6	-0.4	-0.8	0.8	-0.7	-0.2
Reaction time trials completed	0.7	1.0	1.9	0.5	1.4	-1.4	0.9	0.6
Reaction time trials AUC	0.9	1.3	2.6	0.4	1.6	-1.6	0.9	0.5
Social response proportion	0.5	0.6	0.6	-0.6	-0.8	0.8	-0.8	-0.8
Social responses	5.1	6.6	10.5	-2.8	-1.6	1.6	-3.2	-3.0
Social time	0.5	0.6	1.0	0.9	0.5	-0.5	1.0	0.9
Conditioned locomotion	1.7	2.0	2.9	1.0	1.7	-1.7	1.5	1.1
Cocaine response after cond. corrected	3.7	4.2	6.4	2.0	1.8	-1.8	2.5	2.1
Cocaine response after cond. not corrected	4.1	4.6	6.8	2.0	1.9	-1.9	2.6	2.1
Cocaine response before conditioning	0.3	0.4	0.6	-0.6	-0.5	0.5	-0.8	-0.7
Saline control response	0.1	0.1	0.3	0.1	0.5	-0.5	0.3	0.1
Condit. Reinf. active minus inactive responses	2.0	2.4	4.1	-2.0	0.8	-0.8	-1.7	-1.9
Condit. Reinf. active-inactive response ratio	1.3	1.3	2.7	-0.8	1.6	-1.6	-0.2	-0.7
Condit. Reinf. active responses	1.5	2.1	3.6	-1.9	-0.1	0.1	-1.9	-1.9
Condit. Reinf. inactive responses	1.0	1.2	1.8	-1.0	-0.9	0.9	-1.3	-1.1
Condit. Reinf. lever presses	1.8	2.5	4.3	-2.1	0.7	-0.7	-1.8	-2.0
Condit. Reinf. lever reinforcers received	1.3	1.8	3.2	-1.7	0.3	-0.3	-1.6	-1.8
Pavlov. Cond. lever latency	0.6	0.8	1.3	1.1	0.3	-0.3	1.2	1.1
Pavlov. Cond. magazine entry latency	0.4	0.4	0.7	-0.7	-0.5	0.5	-0.9	-0.6
Pavlov. Cond. change in total contacts	0.6	0.9	1.5	-1.2	0.0	-0.0	-1.2	-1.2
Pavlov. Cond. index score	0.6	0.8	1.4	-1.2	-0.1	0.1	-1.2	-1.1
Pavlov. Cond. latency score	0.6	0.7	1.3	-1.0	-0.4	0.4	-1.2	-1.0
Pavlov. Cond. lever contacts	0.6	0.8	1.4	-1.2	0.2	-0.2	-1.1	-1.2
Pavlov. Cond. magazine entry number	0.6	0.7	1.3	1.0	0.6	-0.6	1.1	0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	0.5	1.0	-1.0	0.8	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.5	-1.1	-0.3	0.3	-1.2	-1.1
Pavlov. Cond. response bias	1.3	1.8	3.2	-1.8	0.2	-0.2	-1.7	-1.7
Conditioned reinforcement - actives	1.8	1.7	3.1	-1.6	-0.5	0.5	-1.7	-1.6
Conditioned reinforcement - inactives	0.8	0.9	1.5	0.5	1.2	-1.2	0.9	0.6
Conditioned locomotion	5.3	6.3	10.7	-3.2	-0.3	0.3	-3.3	-3.2
Intermittent access intake day 1-15 change	4.7	4.7	8.2	-2.9	0.3	-0.3	-2.7	-2.8
Intermittent access intake escalation	5.6	5.5	9.3	-3.0	1.4	-1.4	-2.5	-2.9
Intermittent access intake escalation 2	6.5	6.4	10.9	-3.3	1.3	-1.3	-2.8	-3.2
Intermitt. access day 1 inactive lever presses	0.7	0.7	0.9	-0.9	0.8	-0.8	-0.6	-0.9
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	-0.8	0.5	-0.5	-0.6	-0.7
Intermitt. access escalation Index	1.2	1.0	1.9	0.8	-1.4	1.4	0.3	0.8
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.3	-0.1	0.1	0.3	0.4
Intermittent access day 15 total infusions	1.5	1.7	2.9	-1.7	0.8	-0.8	-1.4	-1.5
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.4	-1.2	0.0	-0.0	-1.2	-1.0
Intermittent access total infusions	0.2	0.2	0.3	-0.6	0.4	-0.4	-0.4	-0.4
Intermittent access day 1 locomotion	0.2	0.3	0.4	-0.6	0.4	-0.4	-0.5	-0.5
Intermittent access day 15 total locomotion	2.5	2.6	4.7	-2.2	0.5	-0.5	-2.0	-2.0
Intermittent access total locomotion	0.7	0.8	1.4	-1.2	0.1	-0.1	-1.1	-1.0
Intermittent access standard deviation	2.3	2.5	4.4	-2.1	0.4	-0.4	-1.9	-2.0
Cocaine induced anxiety	1.0	1.1	1.9	-0.6	-1.4	1.4	-1.0	-0.7
Post-drug Anxiety	1.3	1.5	3.3	-0.2	-1.8	1.8	-0.7	-0.4
Baseline Anxiety	0.2	0.2	0.4	-0.3	0.6	-0.6	-0.1	-0.2
Lifetime Intake	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.3	-0.1
Incentive Sensitization - Responses	0.4	0.4	0.6	-0.8	0.4	-0.4	-0.6	-0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.6	-0.8	0.2	-0.2	-0.7	-0.8
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	0.2	0.6	-0.6	0.4	0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.2	0.3	0.5	-0.5	0.5	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.1	-0.0
Progressive ratio test 2 active lever presses	0.3	0.3	0.5	-0.7	0.5	-0.5	-0.5	-0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.6	-0.0	0.0	-0.6	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.3	-0.1
Total sessions with >9 infusions	0.4	0.4	0.9	0.2	-1.0	1.0	-0.1	0.2
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.2	-0.2
Short access day 10 total inactive lever presses	0.3	0.4	0.7	-0.5	0.8	-0.8	-0.2	-0.4
Short access day 1 total infusions	0.4	0.4	0.9	-0.0	-0.9	0.9	-0.4	0.0
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	0.1
Short access total infusions	0.1	0.1	0.3	0.1	-0.5	0.5	-0.1	0.2
Short access day 1 locomotion	0.5	0.6	1.0	-0.8	-0.6	0.6	-1.0	-0.7
Short access day 10 total locomotion	3.0	3.3	5.9	-2.4	0.5	-0.5	-2.2	-2.3
Short access total locomotion	0.6	0.6	1.1	-1.0	-0.3	0.3	-1.1	-0.8
Compulsive drug intake	0.7	0.7	1.3	1.1	-0.4	0.4	1.0	0.9
One hour access (0.3 mA shock)	0.1	0.2	0.3	0.4	0.3	-0.3	0.5	0.5
One hour access (shock baseline)	0.2	0.3	0.6	-0.4	0.8	-0.8	-0.1	-0.2
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	-0.1	0.1	-0.5	-0.3
Context. condit. distance diff. score	0.2	0.3	0.4	0.6	0.3	-0.3	0.6	0.7
Locomotion velocity, session 1	1.1	1.2	2.2	-0.4	-1.5	1.5	-0.9	-0.6
Locomotion distance, session 1	1.2	1.5	3.7	0.3	-1.9	1.9	-0.4	0.0
Locomotion velocity, session 2	3.2	3.8	4.7	-1.5	-2.2	2.2	-2.1	-1.7
Locomotion distance, session 2	2.0	2.8	5.0	-0.8	-2.2	2.2	-1.5	-1.0
Locomotion velocity, session 3	3.9	4.6	7.6	-2.8	-0.2	0.2	-2.8	-2.8
Locomotion distance, session 3	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.0	-0.2
Stereotopy head waving bouts, day 3	2.9	3.5	6.0	-2.2	-1.0	1.0	-2.5	-2.2
Stereotopy head waving duration, day 3	3.4	4.1	7.1	-2.5	-0.8	0.8	-2.7	-2.5
Locomotion velocity, session 7	0.6	0.6	1.0	-0.8	-0.6	0.6	-1.0	-0.9
Locomotion distance, session 7	0.3	0.3	0.8	-0.0	0.9	-0.9	0.3	0.0
Stereotopy head waving bouts, day 7	0.8	0.9	2.0	0.4	-1.4	1.4	-0.1	0.3
Stereotopy head waving duration, day 7	0.9	1.1	2.7	0.1	-1.6	1.6	-0.5	-0.0
Locomotion velocity, session 8	1.6	1.9	4.4	-0.1	-2.1	2.1	-0.8	-0.2
Locomotion distance, session 8	0.2	0.3	0.5	-0.1	-0.7	0.7	-0.4	-0.2
Degree of sensitization distance	0.3	0.3	0.5	0.7	0.0	-0.0	0.6	0.7
Degree of sensitization stereotypy	1.7	1.9	2.9	1.7	-1.0	1.0	1.4	1.6
Condit. Reinf. active minus inactive responses	2.6	2.9	5.1	-2.1	-0.5	0.5	-2.3	-2.2
Condit. Reinf. active-inactive response ratio	1.6	1.7	3.0	-1.7	0.5	-0.5	-1.5	-1.7
Condit. Reinf. active responses	2.5	3.1	4.9	-1.8	-1.3	1.3	-2.2	-1.9
Condit. Reinf. inactive responses	1.1	1.3	2.5	-0.5	-1.6	1.6	-1.0	-0.7
Incentive salience index mean	1.6	2.0	3.0	-1.4	-1.2	1.2	-1.7	-1.4
Condit. Reinf. lever presses	1.4	1.9	4.5	0.4	-2.1	2.1	-0.3	0.3
Time in familiar zone, hab. session 1	1.5	1.4	2.5	-1.6	0.3	-0.3	-1.4	-1.6
Time in novel zone, hab. session 1	1.4	1.3	1.7	1.3	-1.1	1.1	0.9	1.2
Total zone transitions, hab. session 1	1.1	1.6	2.8	-0.6	-1.7	1.7	-1.2	-0.8
Total locomotion distance, hab. session 1	2.3	3.3	7.0	-0.5	-2.7	2.7	-1.3	-0.8
Locomotion velocity, hab. session 1	1.9	2.7	4.8	-0.8	-2.2	2.2	-1.5	-1.1
Time in familiar zone, hab. session 2	4.6	4.8	8.4	-2.9	0.8	-0.8	-2.5	-2.8
Time in novel zone, hab. session 2	3.7	3.8	6.3	2.5	-1.0	1.0	2.1	2.4
Total zone transitions, hab. session 2	1.4	1.8	3.7	1.0	-1.9	1.9	0.3	0.7
Total locomotion distance, hab. session 2	1.1	1.4	2.4	-0.6	-1.6	1.6	-1.1	-0.9
Locomotion velocity, hab. session 2	1.4	1.8	3.7	-0.5	-1.9	1.9	-1.1	-0.7
Novel to familiar place preference ratio	3.5	3.6	5.8	2.4	-1.3	1.3	1.9	2.3
Novelty place preference	2.3	2.4	3.5	1.9	-1.3	1.3	1.4	1.8
Time in novel zone, NPP test	2.4	2.5	3.9	2.0	-1.2	1.2	1.6	1.9
Total zone transitions, NPP test	0.3	0.5	1.0	0.4	-1.0	1.0	0.1	0.2
Total locomotion distance, NPP test	0.7	1.0	2.2	0.6	-1.5	1.5	0.1	0.3
Locomotion velocity, NPP test	0.6	0.9	2.1	0.3	-1.4	1.4	-0.2	0.0
Pavlov. Cond. lever latency	0.7	0.8	2.0	-0.5	1.4	-1.4	-0.0	-0.3
Pavlov. Cond. magazine entry latency	1.8	2.3	3.9	-2.0	0.1	-0.1	-1.9	-1.9
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.2	-0.3
Pavlov. Cond. index score	0.4	0.6	0.9	-0.4	-1.0	1.0	-0.7	-0.5
Pavlov. Cond. latency score	0.7	0.9	1.8	-0.3	-1.4	1.4	-0.7	-0.4
Pavlov. Cond. lever contacts	1.0	1.2	2.9	0.3	-1.7	1.7	-0.3	0.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	0.8	0.2	-0.2	0.9	0.8
Pavlov. Cond. intertrial magazine entries	0.5	0.5	1.1	-0.6	1.0	-1.0	-0.3	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	-0.7	-0.9	0.9	-1.0	-0.8
Pavlov. Cond. response bias	0.6	0.8	1.3	-1.1	-0.3	0.3	-1.2	-1.1
Bone: apparent density	2.1	3.5	8.2	0.8	-2.9	2.9	-0.1	0.5
Bone surface	4.0	7.1	17.2	0.6	-4.1	4.1	-0.8	0.3
Bone volume	4.2	7.0	17.1	0.6	-4.1	4.1	-0.8	0.2
Bone: connectivity density	1.5	2.3	4.8	1.1	-2.2	2.2	0.3	0.8
Bone: cortical apparent density	0.7	0.9	1.9	1.1	0.3	-0.3	1.1	1.4
Bone: cortical area	1.1	1.7	2.3	1.3	-1.5	1.5	0.7	1.3
Bone: cortical porosity	0.5	0.5	0.7	-0.6	-0.8	0.8	-0.8	-0.6
Bone: cortical porosity	0.6	0.6	1.6	0.2	-1.3	1.3	-0.2	0.1
Bone: cortical thickness	0.9	1.5	2.7	1.6	-0.6	0.6	1.3	1.6
Bone: cortical thickness	0.3	0.3	0.8	-0.3	0.9	-0.9	-0.0	-0.3
Bone: cortical tissue density	0.5	0.7	1.4	0.9	0.4	-0.4	0.9	1.2
Bone: elastic displacement	0.2	0.2	0.3	-0.6	-0.2	0.2	-0.6	-0.5
Bone: elastic work	0.3	0.3	0.4	0.6	-0.6	0.6	0.4	0.6
Bone: endosteal estimation	0.3	0.7	0.8	0.9	-0.8	0.8	0.6	0.9
Bone: endosteal perimeter	0.5	1.0	2.2	-0.3	-1.5	1.5	-0.8	-0.3
Bone: final force	1.3	2.1	3.1	1.8	-1.3	1.3	1.3	1.7
Bone: final moment	1.1	1.8	2.5	1.6	-1.2	1.2	1.1	1.5
Bone: marrow area	0.3	0.7	0.8	0.9	-0.8	0.8	0.6	0.9
Bone: maximum diameter	0.9	1.7	3.1	-0.6	-1.8	1.8	-1.2	-0.6
Bone: maximum force	1.2	2.0	3.2	1.8	-1.0	1.0	1.4	1.8
Bone: maximum moment	1.0	1.7	2.7	1.6	-0.9	0.9	1.2	1.6
Bone: minimum diameter	0.3	0.6	1.4	0.4	-1.2	1.2	-0.0	0.4
Bone: periosteal estimation	0.9	1.8	2.7	1.3	-1.6	1.6	0.7	1.3
Bone: periosteal perimeter	0.8	1.3	3.1	0.2	-1.8	1.8	-0.4	0.2
Bone: post-yield work	0.4	0.6	1.1	0.9	0.2	-0.2	0.9	1.0
Bone: stiffness	2.2	3.5	6.2	2.5	-0.6	0.6	2.2	2.4
Bone: tissue strength	1.3	1.3	2.5	1.5	-0.2	0.2	1.3	1.6
Bone: trabecular number	1.4	2.1	4.2	-0.5	-2.1	2.1	-1.1	-0.8
Bone: trabecular spacing	2.5	3.2	7.6	-0.1	2.8	-2.8	0.8	0.1
Bone: trabecular thickness	4.8	5.8	13.8	0.9	-3.7	3.7	-0.3	0.6
Bone: trabecular tissue density	1.9	2.7	3.3	1.4	1.6	-1.6	1.8	1.8
Breakpoint value in progressive ratio session	3.6	4.0	7.5	-2.7	0.4	-0.4	-2.5	-2.5
Distance traveled before self-admin	0.2	0.2	0.3	0.6	-0.4	0.4	0.5	0.6
Distance traveled after self-admin	0.7	0.8	1.5	-1.2	-0.4	0.4	-1.1	-1.0
Delta time in closed arm before/after self-admin	2.0	1.9	4.4	0.1	2.1	-2.1	0.8	0.2
Delta time in open arm before/after self-admin	0.8	0.8	1.6	0.9	-0.1	0.1	1.2	1.3
Diff in mean of infusions in LGA sessions	1.2	1.3	3.0	-1.7	-0.0	0.0	-1.3	-1.3
Extinction: sum of active levers before priming	1.7	1.7	2.9	-1.7	1.2	-1.2	-1.1	-1.3
Active lever presses in extinction session 6	1.9	1.8	3.4	-1.5	-0.4	0.4	-1.8	-1.7
Delta distance traveled before/after self-admin	1.0	1.1	1.8	-1.3	-0.1	0.1	-1.3	-1.3
Delta ambulatory time before/after self-admin	1.2	1.3	2.1	-1.4	-0.7	0.7	-1.4	-1.3
Time in closed arm before self-admin	1.2	1.3	2.6	1.6	-0.9	0.9	0.9	1.2
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	-0.3
Time in open arm before self-admin	0.8	0.9	1.6	-1.1	0.2	-0.2	-1.1	-1.3
Time in open arm after self-admin	0.4	0.5	0.8	0.5	0.5	-0.5	0.9	0.9
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.4	0.3	-0.3	0.0	0.0
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.4	0.5	-1.6	1.6	-0.9	-0.5
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.9	-0.3	1.0	-1.0	-0.2	-0.6
Time to tail flick, test, before self-admin	1.2	1.2	2.8	0.5	-1.7	1.7	-0.5	-0.1
Time to tail flick, test, after self-admin	0.4	0.4	0.9	0.1	-0.9	0.9	-0.5	-0.2
Delta time to tail flick, vehicle, before/after SA	1.4	1.3	2.9	-0.3	1.7	-1.7	0.8	0.3
Delta time to tail flick, test, before/after SA	0.6	0.5	1.1	-0.5	1.0	-1.0	-0.2	-0.5
Ambulatory time before self-admin	0.1	0.1	0.2	0.5	-0.1	0.1	0.4	0.5
Ambulatory time after self-admin	0.4	0.5	1.0	-1.0	-0.3	0.3	-0.8	-0.7
Total heroin consumption	1.2	1.5	2.6	-1.5	-0.4	0.4	-1.6	-1.4
Area under the delay curve	1.5	1.6	2.8	1.7	-0.4	0.4	1.5	1.6
Delay disc. indifference point, 0s delay	6.2	6.8	11.1	3.3	-1.6	1.6	2.8	3.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.4	-0.2	0.2	0.4	0.4
Delay disc. indifference point, 2s delay	4.1	4.6	8.0	2.8	-0.7	0.7	2.6	2.7
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.7	0.1	-0.1	0.7	0.7
Delay disc. indifference point, 4s delay	1.3	1.3	1.8	1.4	-1.1	1.1	1.0	1.2
Delay disc. indifference point, 8s delay	0.7	0.7	1.2	0.9	0.6	-0.6	1.1	0.9
Delay discount exponential model param	1.3	1.4	2.4	-1.6	0.3	-0.3	-1.4	-1.5
Delay discount hyperbolic model param	1.9	2.0	3.5	-1.9	0.4	-0.4	-1.7	-1.8
Fecal boli incidents, locomotor time 1	1.5	1.6	2.4	1.2	1.2	-1.2	1.5	1.2
Change in fecal boli incidents, locomotor task	1.0	1.0	2.2	-0.2	-1.5	1.5	-0.7	-0.3
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.0	0.8	-1.0	1.0	0.5	0.8
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.5	0.1	-0.1	-0.4	-0.4
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.5	-0.4
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.5	-0.2
Distance moved, locomotor task time 1	0.8	0.9	1.2	0.9	-1.1	1.1	0.6	0.8
Vertical activity count, locomotor time 1	0.1	0.1	0.1	0.1	0.3	-0.3	0.2	0.1
Time >=10cm from walls, locomotor time 2	0.8	0.8	1.3	0.9	0.8	-0.8	1.1	0.9
Bouts of movement, locomotor time 2	0.8	0.8	1.7	-0.3	-1.3	1.3	-0.7	-0.4
Total resting periods, locomotor time 2	0.9	0.9	2.0	-0.2	-1.4	1.4	-0.7	-0.3
Rest time, locomotor task time 2	0.5	0.6	0.8	-0.5	-0.9	0.9	-0.8	-0.6
Distance moved, locomotor task time 2	0.7	0.8	1.0	0.7	0.9	-0.9	1.0	0.8
Vertical activity count, locomotor time 2	1.1	1.2	2.2	0.5	1.5	-1.5	1.0	0.7
Weight adjusted by age	0.4	0.4	0.7	0.3	0.9	-0.9	0.6	0.4
Seeking ratio, delayed vs. immediate footshock	3.2	3.7	6.3	-2.3	-0.9	0.9	-2.5	-2.3
Locomotion in novel chamber	0.4	0.5	0.8	-0.9	0.4	-0.4	-0.8	-0.9
Locomotion in novel chamber post-restriction	0.5	0.6	1.0	-0.9	-0.1	0.1	-1.0	-1.0
Progressive ratio	0.1	0.2	0.3	0.3	0.5	-0.5	0.5	0.2
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.3	-0.1	0.1	-0.3	-0.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	-0.2	-0.2	0.2	-0.4	-0.3
Run reversals in cocaine runway, females	0.8	0.8	1.1	-0.5	-1.1	1.1	-0.8	-0.8
Run reversals in cocaine runway, males	1.0	0.9	1.4	-0.9	-0.8	0.8	-1.2	-1.1
Latency to leave start box in cocaine runway	1.2	1.3	2.2	-0.7	-1.5	1.5	-1.2	-0.5
Latency to leave start box in cocaine runway, F	1.7	1.9	4.4	0.5	-2.1	2.1	-0.2	0.5
Latency to leave start box in cocaine runway, M	2.5	2.4	4.2	-2.0	1.0	-1.0	-1.7	-1.8
Cd content in liver	0.1	0.1	0.2	0.5	-0.1	0.1	0.4	0.5
Co content in liver	0.5	0.6	1.0	-1.0	0.5	-0.5	-0.8	-1.0
Cu content in liver	0.6	0.7	1.6	0.6	-1.2	1.2	0.2	0.5
Fe content in liver	0.2	0.2	0.4	-0.3	0.6	-0.6	-0.0	-0.2
K content in liver	0.7	0.7	1.6	0.3	-1.3	1.3	-0.1	0.2
Mg content in liver	1.0	1.0	2.4	0.4	-1.6	1.6	-0.1	0.2
Mn content in liver	3.0	3.5	7.8	-0.3	-2.8	2.8	-1.2	-0.5
Na content in liver	1.0	1.0	1.6	1.3	-0.8	0.8	1.0	1.2
Rb content in liver	1.0	1.2	2.0	1.0	-1.4	1.4	0.5	1.0
Se content in liver	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.5	-0.5
Sr content in liver	0.8	0.7	1.7	-0.4	1.3	-1.3	0.0	-0.3
Zn content in liver	2.8	3.1	4.1	-2.0	1.7	-1.7	-1.4	-1.9