Hub : Genes

Acnat1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	ENSRNOT00000100761	0.02	0.02	2.4e-03	0.02	0.01	0.01	0.01	2.6e-03	1.0e-02	1.6e-02	2.5e-02
2	Eye	gene expression	ENSRNOG00000065119	0.72	0.13	1.5e-06	0.18	0.18	0.19	0.26	1.2e-03	8.5e-04	7.9e-04	8.1e-05
3	Liver	gene expression	ENSRNOG00000065119	0.83	0.06	0.0e+00	0.61	0.58	0.66	0.66	1.8e-85	9.2e-80	4.8e-97	3.5e-99
4	Liver	isoform ratio	ENSRNOT00000078547	0.36	0.11	0.0e+00	0.19	0.18	0.2	0.2	4.0e-21	2.8e-19	1.2e-21	2.1e-21
5	Liver	isoform ratio	ENSRNOT00000100761	0.39	0.13	0.0e+00	0.19	0.14	0.2	0.2	6.5e-21	2.8e-15	5.5e-22	1.5e-21
6	Liver	intron excision ratio	chr5:63765256:63766255	0.49	0.12	0.0e+00	0.45	0.45	0.48	0.49	2.0e-54	2.3e-55	5.9e-61	2.8e-62
7	Liver	intron excision ratio	chr5:63797306:63799581	0.78	0.09	0.0e+00	0.43	0.51	0.56	0.56	7.0e-52	1.4e-65	1.8e-75	1.5e-75
8	Liver	mRNA stability	ENSRNOG00000065119	0.62	0.1	0.0e+00	0.51	0.51	0.53	0.54	1.8e-65	2.9e-65	4.7e-69	1.5e-70
9	NAcc	gene expression	ENSRNOG00000065119	0.11	0.06	9.6e-10	0.11	0.12	0.12	0.11	7.5e-09	2.0e-09	5.4e-09	8.6e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
BMI with tail	1.6	5.1	11.5	0.0	-2.9	2.5	0.3	-0.3	-3.4	1.3	3.1	3.0
BMI without tail	1.1	2.3	6.2	0.0	-1.7	1.4	0.5	1.0	-2.5	0.0	2.1	1.9
Body weight	1.9	7.9	17.1	0.0	-4.1	3.0	1.6	-1.2	-3.5	2.0	3.3	3.7
Epididymis fat weight	2.1	5.0	9.3	0.0	-3.0	2.4	1.4	-0.7	-3.0	1.4	2.8	2.9
Glucose	0.1	0.2	1.0	0.0	-0.5	0.3	1.0	-0.0	-0.3	0.2	0.3	0.4
Heart weight	1.0	1.5	4.5	0.0	-1.3	1.3	2.1	-0.3	-1.5	0.7	1.2	1.1
Left kidney weight	1.8	5.2	11.5	0.0	-2.6	2.6	1.6	-0.2	-3.4	1.3	3.1	2.8
Right kidney weight	2.9	8.4	19.5	0.0	-3.5	3.3	1.2	0.1	-4.4	1.4	4.0	3.7
Tail length	0.2	0.5	1.7	0.0	-1.2	0.3	1.3	0.2	-0.4	-0.1	0.3	0.8
Length with tail	1.1	3.9	8.5	0.0	-2.9	2.0	2.7	-1.6	-1.6	1.7	1.6	2.2
Length without tail	0.8	1.7	4.7	0.0	-2.2	1.3	0.9	-1.4	-1.0	1.3	1.0	1.6
Liver weight, left	1.1	1.8	4.9	0.0	-1.1	-0.1	-2.2	2.2	-1.3	-1.5	0.8	1.0
Liver weight, right	0.1	0.2	0.5	0.0	-0.5	0.1	-0.5	0.7	-0.7	-0.4	0.4	0.4
Parametrial fat weight	0.3	0.5	1.1	0.0	-1.0	0.8	-0.6	-0.2	-1.0	0.4	0.9	0.9
Retroperitoneal fat weight	3.1	10.4	17.6	0.0	-4.2	3.6	2.7	-1.6	-3.9	2.5	3.8	4.1
Intraocular pressure	0.1	0.1	0.7	0.0	0.8	-0.1	0.3	0.4	0.1	-0.2	0.0	-0.4
Extensor digitorum longus weight	0.0	0.1	0.5	0.0	0.7	0.1	0.4	-0.1	-0.2	0.2	0.2	-0.3
Soleus weight	0.4	1.1	2.5	0.0	-1.2	1.2	-0.7	0.2	-1.6	0.4	1.5	1.4
Tibialis anterior weight	0.0	0.0	0.1	0.0	0.4	0.1	-0.2	0.0	-0.2	0.1	0.2	-0.2
Tibia length	0.1	0.3	1.5	0.0	-1.2	0.1	0.7	-0.4	-0.1	0.2	-0.1	0.5
Number of licking bursts	0.5	0.6	4.1	0.0	0.4	0.3	2.0	-0.8	0.1	0.7	0.1	-0.2
Food consumed during 24 hour testing period	0.1	0.2	0.6	0.0	0.8	-0.2	0.3	-0.3	0.5	0.1	-0.4	-0.6
Times rat made contact with spout	0.9	1.1	3.0	0.0	-0.7	1.1	1.7	-1.2	-0.8	1.2	0.9	0.8
Mean time between licks in bursts	0.1	0.1	0.2	0.0	0.4	-0.3	0.1	-0.1	0.4	-0.0	-0.4	-0.4
Mean num. licks in bursts	0.2	0.3	2.0	0.0	-0.3	-0.2	-1.4	0.4	-0.1	-0.4	-0.1	0.1
Std. dev. time between licks in bursts	0.3	0.3	0.7	0.0	0.8	-0.5	0.0	-0.5	0.8	0.1	-0.7	-0.7
Water consumed over 24 hours	2.2	2.6	6.9	0.0	-0.7	1.7	2.6	-2.3	-0.9	2.2	1.2	0.9
Indifference point 0 sec	0.5	0.8	2.1	0.0	1.5	-0.8	-1.0	0.4	0.9	-0.5	-0.9	-1.1
Indifference point AUC	0.1	0.1	0.3	0.0	0.0	0.5	0.5	-0.4	-0.2	0.6	0.5	0.0
Indifference point function ln k	0.6	0.8	2.3	0.0	-1.1	1.0	-0.1	0.1	-1.5	0.3	1.3	1.2
Indifference point function log k	0.6	0.8	2.3	0.0	-1.1	1.0	-0.1	0.1	-1.5	0.3	1.3	1.2
Delay discounting total patch changes 0 sec	0.1	0.2	0.7	0.0	0.8	-0.3	-0.8	0.2	0.2	-0.2	-0.3	-0.5
Delay discounting total patch changes 12 sec	0.2	0.2	0.8	0.0	0.9	-0.2	0.1	-0.3	0.6	0.2	-0.4	-0.8
Delay discounting total patch changes 18 sec	0.6	0.8	1.9	0.0	1.4	-0.6	-1.0	-0.4	1.1	0.1	-0.9	-1.3
Delay discounting total patch changes 24 sec	0.5	0.7	2.6	0.0	0.4	-0.8	-1.6	0.7	0.7	-0.8	-0.7	-0.6
Delay discounting total patch changes 6 sec	0.0	0.1	0.4	0.0	0.6	0.1	0.2	-0.1	0.0	0.2	0.1	-0.4
Delay discounting time to switch 0 sec	1.5	2.3	3.7	0.0	1.6	-1.7	-1.5	0.9	1.8	-1.3	-1.9	-1.8
Delay discounting water rate 0 sec	1.1	1.7	4.0	0.0	-1.2	1.6	0.7	-0.2	-2.0	0.9	1.9	1.6
Delay discounting water rate 12 sec	1.0	1.5	3.8	0.0	-0.9	1.5	0.5	-0.1	-2.0	0.8	1.9	1.3
Delay discounting water rate 18 sec	4.3	5.7	8.4	0.0	-2.1	2.9	2.6	-1.8	-2.9	2.4	2.8	2.4
Delay discounting water rate 24 sec	2.2	3.0	5.2	0.0	-1.2	2.1	1.8	-1.3	-2.2	1.7	2.3	1.9
Delay discounting water rate 6 sec	2.4	3.5	5.8	0.0	-2.2	2.1	1.3	-1.2	-2.3	1.7	2.3	2.4
Locomotor activity	0.6	0.9	2.2	0.0	-1.5	0.1	-0.4	1.4	-1.0	-0.9	0.6	1.2
Locomotor testing distance	0.4	0.7	2.2	0.0	-0.5	-0.6	-1.5	1.4	-0.1	-1.2	-0.2	0.4
Locomotor testing rearing	0.0	0.0	0.3	0.0	-0.0	-0.1	-0.5	-0.2	0.0	0.1	-0.0	0.2
Light reinforcement 1	0.6	1.1	5.6	0.0	-0.8	-0.2	-2.4	1.3	-0.5	-1.0	0.1	0.6
Light reinforcement 2	0.5	0.6	3.2	0.0	-0.8	0.4	-1.8	0.5	-0.8	-0.2	0.6	0.7
Reaction time number correct	0.4	0.6	1.4	0.0	-1.2	0.5	-0.4	0.6	-1.1	-0.2	0.9	1.2
Reaction time mean minus median	0.8	1.1	3.9	0.0	2.0	-0.9	-1.0	0.5	1.0	-0.6	-0.8	-1.5
Reaction time mean minus median AUC	0.4	0.5	2.7	0.0	1.6	-0.3	0.1	-0.3	0.8	0.1	-0.5	-1.1
Reaction time num false alarms	4.9	6.7	11.0	0.0	-2.3	3.2	2.3	-1.8	-3.2	2.6	3.3	3.0
Reaction time num false alarms AUC	4.9	6.9	11.0	0.0	-2.1	3.2	3.0	-1.7	-3.1	2.6	3.3	2.9
Reaction time trials correct on left	0.4	0.6	1.4	0.0	-1.2	0.5	-0.4	0.6	-1.1	-0.2	0.9	1.2
Reaction time trials on left	0.5	0.7	1.4	0.0	-1.2	0.5	-0.5	0.7	-1.2	-0.3	0.9	1.2
Reaction time mean	0.1	0.2	0.8	0.0	0.4	0.3	-0.9	0.3	-0.4	-0.0	0.4	-0.4
Reaction time mean AUC	0.2	0.2	0.9	0.0	0.9	-0.0	-0.6	0.2	0.1	-0.1	-0.0	-0.9
Median of all reaction times	0.2	0.3	0.7	0.0	-0.3	0.8	-0.7	0.1	-0.9	0.3	0.8	0.1
Reaction time omissions	1.4	1.9	8.9	0.0	0.4	-0.6	-3.0	2.1	-0.4	-1.6	0.0	-0.1
Reaction time false alarm rate	3.7	5.2	7.9	0.0	-1.5	2.8	2.8	-1.9	-2.5	2.6	2.8	2.2
Reaction time premature initiation rate	0.2	0.2	1.0	0.0	-0.0	0.1	-0.2	-1.0	0.6	0.6	-0.4	-0.2
Reaction time premature initiations	0.2	0.3	0.6	0.0	-0.7	0.6	-0.2	-0.8	-0.3	0.6	0.3	0.6
Std. dev. reaction times	0.4	0.6	2.2	0.0	1.3	-0.2	-1.5	0.6	0.1	-0.4	-0.0	-0.9
Reaction time trials completed	0.5	0.7	1.4	0.0	-1.2	0.5	-0.5	0.7	-1.2	-0.3	0.9	1.2
Reaction time trials AUC	0.5	0.8	1.6	0.0	-1.3	0.5	-0.7	0.7	-1.2	-0.3	0.9	1.3
Social response proportion	0.7	0.8	1.5	0.0	0.4	-1.0	1.0	1.2	0.7	-1.2	-0.9	-0.7
Social responses	1.0	1.4	8.6	0.0	1.0	-0.2	2.9	-0.8	0.9	0.4	-0.6	-0.8
Social time	1.1	1.4	3.3	0.0	1.7	-1.0	1.8	0.4	1.2	-0.6	-1.1	-1.5
Conditioned locomotion	0.7	0.9	4.0	0.0	0.7	0.4	2.0	-1.3	0.3	1.0	0.1	-0.3
Cocaine response after cond. corrected	0.2	0.2	0.8	0.0	0.6	-0.4	-0.9	-0.1	0.6	-0.1	-0.5	-0.5
Cocaine response after cond. not corrected	0.2	0.2	0.6	0.0	0.8	0.0	-0.0	-0.8	0.5	0.6	-0.2	-0.5
Cocaine response before conditioning	0.3	0.4	2.6	0.0	0.5	0.3	1.6	-0.6	0.0	0.5	0.2	-0.2
Saline control response	0.4	0.5	2.0	0.0	-0.5	0.5	0.6	-1.4	0.1	1.1	0.2	0.5
Condit. Reinf. active minus inactive responses	1.7	2.1	3.0	0.0	1.2	-1.7	-1.7	1.3	1.5	-1.6	-1.7	-1.5
Condit. Reinf. active-inactive response ratio	1.6	1.7	4.0	0.0	0.6	-1.5	-2.0	1.2	1.2	-1.5	-1.4	-1.1
Condit. Reinf. active responses	1.2	1.7	2.8	0.0	1.7	-1.5	-0.6	1.1	1.4	-1.3	-1.4	-1.7
Condit. Reinf. inactive responses	0.4	0.5	2.8	0.0	0.8	0.3	1.7	-0.5	0.1	0.5	0.2	-0.3
Condit. Reinf. lever presses	0.9	1.3	3.6	0.0	1.9	-1.0	-0.3	-0.2	1.5	-0.3	-1.3	-1.7
Condit. Reinf. lever reinforcers received	1.6	2.2	3.5	0.0	1.9	-1.7	-0.8	1.3	1.5	-1.6	-1.6	-1.9
Pavlov. Cond. lever latency	0.7	0.9	2.2	0.0	-1.5	0.4	-1.1	1.0	-1.2	-0.5	0.9	1.3
Pavlov. Cond. magazine entry latency	1.7	1.9	4.3	0.0	2.1	-1.5	-0.5	0.8	1.6	-1.1	-1.6	-2.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.0	0.3	-0.0	0.3	-0.5	0.3	0.3	-0.3	-0.4
Pavlov. Cond. index score	0.5	0.7	1.8	0.0	1.3	-0.6	0.3	-0.5	1.1	0.1	-0.9	-1.3
Pavlov. Cond. latency score	0.5	0.6	1.8	0.0	1.3	-0.6	0.0	-0.4	1.1	0.0	-0.9	-1.2
Pavlov. Cond. lever contacts	0.7	0.9	2.1	0.0	1.4	-0.7	0.7	-0.7	1.4	0.1	-1.1	-1.3
Pavlov. Cond. magazine entry number	1.1	1.3	2.4	0.0	-1.5	1.3	0.6	-0.7	-1.4	0.9	1.4	1.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.9	0.0	-0.7	0.3	1.0	-0.2	-0.3	0.2	0.3	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.9	0.0	1.4	-0.6	0.5	-0.6	1.2	0.2	-1.0	-1.3
Pavlov. Cond. response bias	0.7	1.0	2.2	0.0	1.5	-0.8	0.8	-0.5	1.4	0.0	-1.1	-1.4
Conditioned reinforcement - actives	6.0	5.9	10.4	0.0	3.2	-2.8	-1.7	2.1	2.7	-2.4	-2.5	-2.9
Conditioned reinforcement - inactives	5.5	6.2	9.6	0.0	2.4	-2.6	-3.1	2.6	2.3	-2.7	-2.5	-2.8
Conditioned locomotion	2.1	2.6	3.6	0.0	1.8	-1.8	-1.5	1.3	1.9	-1.6	-1.8	-1.8
Intermittent access intake day 1-15 change	0.4	0.4	3.3	0.0	0.3	0.4	1.8	-0.0	-0.3	0.2	0.4	-0.2
Intermittent access intake escalation	0.4	0.4	0.6	0.0	0.5	-0.6	0.8	0.6	0.6	-0.7	-0.6	-0.6
Intermittent access intake escalation 2	0.3	0.3	2.3	0.0	-0.3	0.4	1.5	-0.4	-0.3	0.3	0.3	0.3
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.5	0.0	-0.9	0.6	-0.7	-1.2	-0.2	1.0	0.3	0.6
Intermitt. access day 15 inactive lever presses	0.4	0.4	1.0	0.0	-0.8	1.0	-0.0	-0.4	-0.8	0.6	0.8	0.4
Intermitt. access escalation Index	0.1	0.1	0.4	0.0	-0.6	-0.2	0.5	0.1	0.0	-0.2	-0.1	0.5
Intermittent access day 1 total infusions	4.6	5.2	7.5	0.0	2.7	-2.5	-2.7	2.0	2.3	-2.3	-2.3	-2.5
Intermittent access day 15 total infusions	2.9	3.3	5.3	0.0	2.2	-2.1	-0.9	1.7	2.0	-1.9	-2.0	-2.3
Intermittent access terminal intake (last 3 days)	2.8	3.0	4.8	0.0	2.2	-2.1	-0.6	1.6	2.0	-1.8	-1.9	-2.1
Intermittent access total infusions	4.1	4.5	6.3	0.0	2.5	-2.4	-1.9	2.0	2.3	-2.2	-2.2	-2.3
Intermittent access day 1 locomotion	4.5	4.6	10.0	0.0	1.8	-2.3	-3.2	2.1	2.0	-2.3	-2.1	-2.1
Intermittent access day 15 total locomotion	4.1	4.3	6.2	0.0	2.3	-2.4	-1.7	2.4	2.0	-2.5	-2.1	-2.1
Intermittent access total locomotion	5.8	6.5	8.5	0.0	2.6	-2.9	-2.9	2.5	2.6	-2.8	-2.7	-2.7
Intermittent access standard deviation	0.7	0.8	1.4	0.0	0.6	-1.1	-0.3	1.1	1.0	-1.2	-1.0	-0.9
Cocaine induced anxiety	0.1	0.2	0.6	0.0	0.2	-0.2	0.3	-0.1	0.6	-0.1	-0.5	-0.8
Post-drug Anxiety	1.9	2.1	4.5	0.0	-1.3	1.6	2.0	-2.1	-0.8	2.0	1.0	0.8
Baseline Anxiety	4.5	4.7	7.1	0.0	-2.3	2.4	2.1	-1.9	-2.4	2.2	2.4	2.7
Lifetime Intake	4.1	4.6	7.3	0.0	2.7	-2.5	-1.8	1.6	2.6	-2.0	-2.4	-2.5
Incentive Sensitization - Responses	3.5	3.5	7.8	0.0	2.8	-1.9	-1.4	1.6	1.8	-1.7	-1.8	-2.5
Incentive Sensitization - Breakpoint	3.3	3.3	7.4	0.0	2.7	-1.9	-1.3	1.7	1.8	-1.7	-1.7	-2.4
Progressive ratio test 1 active lever presses	4.0	4.1	7.5	0.0	2.4	-2.2	-2.1	0.6	2.7	-1.3	-2.5	-2.5
Progressive ratio test 1 breakpoint	3.4	3.5	6.8	0.0	2.3	-2.1	-1.7	0.4	2.6	-1.0	-2.3	-2.4
Progressive ratio test 1 inactive lever presses	4.2	4.5	7.4	0.0	2.4	-2.2	-2.7	1.0	2.6	-1.5	-2.4	-2.6
Progressive ratio test 2 active lever presses	7.5	8.0	14.8	0.0	3.8	-3.1	-2.1	1.9	3.3	-2.4	-3.1	-3.7
Progressive ratio test 2 breakpoint	5.9	6.5	14.2	0.0	3.8	-2.7	-1.6	1.4	3.0	-1.9	-2.7	-3.6
Progressive ratio test 2 inactive lever presses	4.4	5.1	8.6	0.0	2.9	-2.3	-2.4	1.5	2.5	-1.8	-2.4	-2.9
Total sessions with >9 infusions	3.9	4.3	7.1	0.0	2.6	-2.3	-2.2	0.9	2.7	-1.4	-2.4	-2.5
Short access day 1 total inactive lever presses	0.4	0.5	3.1	0.0	-0.1	-0.5	-1.8	0.7	0.4	-0.6	-0.4	-0.0
Short access day 10 total inactive lever presses	0.3	0.3	0.7	0.0	-0.2	0.8	-0.4	-0.9	-0.5	0.8	0.5	0.2
Short access day 1 total infusions	2.7	2.9	4.7	0.0	2.2	-2.0	-1.6	0.9	2.1	-1.3	-1.9	-1.9
Short access day 10 total infusions	2.9	3.2	5.7	0.0	2.4	-2.1	-1.0	1.3	2.2	-1.6	-2.0	-2.1
Short access total infusions	2.5	2.7	5.9	0.0	2.4	-1.8	-0.9	0.5	2.3	-1.0	-1.9	-2.1
Short access day 1 locomotion	1.6	1.7	2.6	0.0	1.5	-1.6	-0.8	1.0	1.5	-1.3	-1.5	-1.5
Short access day 10 total locomotion	2.2	2.4	4.1	0.0	0.6	-2.0	-2.0	1.6	1.6	-1.9	-1.8	-1.1
Short access total locomotion	1.7	1.8	3.0	0.0	1.3	-1.7	-1.0	0.8	1.7	-1.2	-1.7	-1.5
Compulsive drug intake	0.2	0.2	1.2	0.0	-0.4	-0.5	-1.1	0.1	0.4	-0.4	-0.6	0.1
One hour access (0.3 mA shock)	5.8	6.8	10.4	0.0	3.2	-3.0	-2.3	2.0	2.9	-2.5	-2.9	-3.1
One hour access (shock baseline)	3.3	3.9	5.6	0.0	2.3	-2.2	-1.6	2.3	1.8	-2.4	-1.8	-2.1
Number of responses in last shaping day	0.5	0.5	1.1	0.0	1.0	-0.7	-0.3	0.8	0.6	-0.8	-0.6	-1.1
Context. condit. distance diff. score	0.4	0.5	0.9	0.0	0.6	-0.8	-1.0	0.6	0.7	-0.7	-0.7	-0.6
Locomotion velocity, session 1	0.2	0.2	0.5	0.0	0.2	-0.5	0.2	0.7	0.3	-0.6	-0.4	-0.3
Locomotion distance, session 1	0.6	0.8	2.4	0.0	1.6	-0.9	0.3	0.8	0.7	-0.8	-0.7	-1.3
Locomotion velocity, session 2	0.1	0.2	0.4	0.0	0.6	-0.3	0.6	-0.3	0.5	0.1	-0.4	-0.5
Locomotion distance, session 2	2.4	3.5	8.4	0.0	2.9	-2.0	0.4	0.9	2.2	-1.4	-2.1	-2.6
Locomotion velocity, session 3	0.1	0.1	0.6	0.0	0.0	-0.0	-0.8	0.3	-0.1	-0.2	0.1	0.0
Locomotion distance, session 3	2.5	2.7	6.2	0.0	1.6	-1.6	-2.5	2.1	1.0	-2.0	-1.2	-1.5
Stereotopy head waving bouts, day 3	1.7	2.0	2.9	0.0	-1.7	1.6	1.3	-1.2	-1.5	1.4	1.6	1.7
Stereotopy head waving duration, day 3	3.0	3.6	5.0	0.0	-1.9	2.2	2.0	-1.9	-1.9	2.2	2.1	2.1
Locomotion velocity, session 7	1.1	1.3	2.7	0.0	1.6	-1.1	-0.9	0.1	1.4	-0.5	-1.3	-1.6
Locomotion distance, session 7	2.2	2.9	8.4	0.0	1.5	-1.7	-2.9	1.2	1.5	-1.5	-1.7	-1.7
Stereotopy head waving bouts, day 7	1.2	1.3	5.0	0.0	-0.4	1.2	2.2	-1.0	-0.9	1.2	1.1	0.8
Stereotopy head waving duration, day 7	2.6	3.2	8.8	0.0	-1.1	2.0	3.0	-1.6	-1.7	2.0	1.9	1.5
Locomotion velocity, session 8	0.0	0.1	0.1	0.0	-0.1	0.3	0.0	-0.0	-0.4	0.2	0.4	0.2
Locomotion distance, session 8	1.9	2.9	6.3	0.0	2.5	-1.9	-0.6	0.7	2.0	-1.2	-2.0	-2.3
Degree of sensitization distance	1.1	1.2	3.8	0.0	-0.5	0.9	1.7	-2.0	0.0	1.6	0.3	0.4
Degree of sensitization stereotypy	0.6	0.7	3.4	0.0	0.3	0.6	1.9	-0.9	-0.3	0.9	0.5	0.1
Condit. Reinf. active minus inactive responses	1.5	1.7	13.7	0.0	0.6	-0.0	3.7	-0.7	0.5	0.4	-0.3	-0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	3.5	0.0	-0.4	0.3	1.9	-0.5	-0.1	0.4	0.2	0.3
Condit. Reinf. active responses	1.9	2.3	17.2	0.0	1.0	-0.2	4.2	-0.6	0.8	0.3	-0.5	-0.8
Condit. Reinf. inactive responses	1.2	1.4	5.1	0.0	1.7	-0.8	2.3	0.1	1.2	-0.3	-1.0	-1.4
Incentive salience index mean	1.7	2.1	16.0	0.0	0.3	0.5	4.0	-1.1	0.0	0.9	0.2	-0.1
Condit. Reinf. lever presses	1.0	1.3	8.5	0.0	0.2	0.7	2.9	-1.1	-0.2	1.0	0.5	0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.0	-0.2	0.1	-0.7	0.7	-0.5	-0.4	0.4	0.3
Time in novel zone, hab. session 1	0.9	0.9	1.9	0.0	1.1	-0.5	0.8	-1.0	1.4	0.4	-1.1	-1.2
Total zone transitions, hab. session 1	5.1	7.1	10.2	0.0	3.2	-3.1	-2.4	2.2	2.8	-2.7	-3.0	-3.2
Total locomotion distance, hab. session 1	3.4	4.8	7.1	0.0	2.2	-2.5	-2.7	1.5	2.5	-2.1	-2.6	-2.4
Locomotion velocity, hab. session 1	2.9	4.1	6.2	0.0	2.0	-2.3	-2.5	1.7	2.1	-2.1	-2.3	-2.1
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.0	-0.0	0.1	-0.6	0.1	-0.3	-0.1	0.2	0.2
Time in novel zone, hab. session 2	0.1	0.1	0.8	0.0	0.3	0.1	0.9	-0.3	0.2	0.3	-0.1	-0.3
Total zone transitions, hab. session 2	2.2	2.9	4.2	0.0	1.7	-2.0	-1.4	1.7	1.7	-2.0	-1.9	-1.8
Total locomotion distance, hab. session 2	2.3	3.0	4.5	0.0	1.9	-2.1	-1.3	1.3	2.1	-1.8	-2.1	-2.0
Locomotion velocity, hab. session 2	2.3	3.1	4.3	0.0	1.8	-2.1	-1.8	1.7	1.8	-2.0	-2.0	-1.8
Novel to familiar place preference ratio	1.4	1.5	2.4	0.0	1.5	-1.4	-1.3	1.1	1.2	-1.2	-1.2	-1.5
Novelty place preference	1.3	1.3	1.9	0.0	1.4	-1.3	-1.3	1.1	1.0	-1.2	-1.2	-1.3
Time in novel zone, NPP test	1.5	1.5	2.2	0.0	1.5	-1.4	-1.2	1.0	1.3	-1.2	-1.4	-1.4
Total zone transitions, NPP test	0.5	0.8	1.8	0.0	1.4	-0.7	0.7	-0.4	1.2	-0.0	-1.0	-1.2
Total locomotion distance, NPP test	1.8	2.5	4.7	0.0	1.7	-1.9	-0.9	0.7	2.2	-1.3	-2.1	-1.9
Locomotion velocity, NPP test	1.2	1.7	2.8	0.0	1.5	-1.5	-0.9	0.8	1.7	-1.2	-1.7	-1.6
Pavlov. Cond. lever latency	0.6	0.7	3.6	0.0	-0.7	-0.5	-1.9	1.0	-0.1	-0.9	-0.2	0.4
Pavlov. Cond. magazine entry latency	0.5	0.6	1.3	0.0	-0.7	0.8	1.1	-0.6	-0.8	0.7	0.9	0.8
Pavlov. Cond. change in total contacts	0.8	0.9	5.9	0.0	-0.1	0.4	2.4	-1.0	0.2	0.8	0.1	0.1
Pavlov. Cond. index score	1.2	1.6	4.8	0.0	-0.7	1.3	2.2	-1.4	-0.9	1.5	1.1	0.9
Pavlov. Cond. latency score	1.1	1.4	5.1	0.0	-0.4	1.2	2.3	-1.4	-0.7	1.4	1.0	0.6
Pavlov. Cond. lever contacts	0.9	1.0	5.6	0.0	0.8	0.5	2.4	-1.2	0.2	1.0	0.1	-0.5
Pavlov. Cond. magazine entry number	1.2	1.6	2.3	0.0	1.5	-1.4	-1.4	1.0	1.2	-1.2	-1.3	-1.5
Pavlov. Cond. intertrial magazine entries	3.8	4.5	7.6	0.0	2.6	-2.5	-0.2	1.4	2.6	-2.0	-2.6	-2.8
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	6.2	0.0	-0.6	1.3	2.5	-1.6	-0.8	1.6	1.0	0.8
Pavlov. Cond. response bias	0.5	0.6	2.8	0.0	-0.4	0.7	1.7	-0.8	-0.4	0.8	0.5	0.5
Bone: apparent density	1.0	1.6	3.8	0.0	1.8	-1.2	-0.3	-0.2	2.0	-0.4	-1.6	-1.7
Bone surface	0.4	0.7	2.4	0.0	0.9	-0.7	0.1	-0.6	1.6	0.0	-1.2	-0.9
Bone volume	0.5	0.8	2.1	0.0	1.2	-0.9	-0.4	-0.2	1.5	-0.2	-1.2	-1.1
Bone: connectivity density	1.2	1.8	5.0	0.0	1.6	-1.4	-0.7	-0.3	2.2	-0.4	-1.9	-1.7
Bone: cortical apparent density	0.5	0.7	4.8	0.0	0.3	0.2	2.2	-0.9	0.3	0.7	-0.1	-0.3
Bone: cortical area	0.4	0.7	1.9	0.0	-1.4	0.6	-0.9	-1.0	-0.2	0.7	0.3	1.1
Bone: cortical porosity	2.2	2.3	3.6	0.0	-1.9	1.9	-0.0	-1.5	-1.6	1.7	1.7	1.8
Bone: cortical porosity	1.7	1.8	3.5	0.0	-1.9	1.6	-0.5	-1.1	-1.3	1.3	1.4	1.8
Bone: cortical thickness	0.5	0.9	3.2	0.0	-0.7	0.8	1.0	-1.8	0.0	1.4	0.3	0.7
Bone: cortical thickness	1.6	1.8	5.4	0.0	-1.1	1.6	-0.2	-2.3	-0.7	2.1	1.0	1.2
Bone: cortical tissue density	0.5	0.6	4.4	0.0	0.4	0.2	2.1	-0.8	0.3	0.6	-0.1	-0.3
Bone: elastic displacement	0.4	0.4	0.9	0.0	0.6	-0.4	-0.9	-0.7	0.9	0.3	-0.8	-0.7
Bone: elastic work	0.4	0.5	2.2	0.0	0.1	0.5	-0.8	-1.5	0.2	1.1	0.1	0.0
Bone: endosteal estimation	0.2	0.4	1.1	0.0	-1.0	0.6	-0.3	-0.5	-0.5	0.5	0.5	0.9
Bone: endosteal perimeter	0.9	1.9	5.5	0.0	-2.1	0.2	-2.3	1.3	-1.1	-0.9	0.7	1.6
Bone: final force	0.2	0.3	0.5	0.0	-0.6	0.7	-0.4	-0.4	-0.6	0.6	0.7	0.7
Bone: final moment	0.3	0.5	0.8	0.0	-0.7	0.8	-0.6	-0.4	-0.8	0.6	0.9	0.9
Bone: marrow area	0.2	0.4	1.3	0.0	-1.1	0.6	-0.2	-0.6	-0.6	0.6	0.6	1.0
Bone: maximum diameter	0.8	1.5	6.2	0.0	-2.0	0.3	-2.5	0.6	-0.7	-0.5	0.5	1.5
Bone: maximum force	0.7	1.2	1.8	0.0	-1.0	1.3	1.2	-1.3	-0.9	1.3	1.1	1.1
Bone: maximum moment	0.8	1.3	2.0	0.0	-1.1	1.4	1.0	-1.2	-1.1	1.3	1.3	1.3
Bone: minimum diameter	0.3	0.5	3.4	0.0	-0.6	0.0	-1.8	-0.4	0.2	0.2	-0.1	0.5
Bone: periosteal estimation	0.5	1.1	3.1	0.0	-1.8	0.9	-0.9	-1.0	-0.6	0.9	0.7	1.5
Bone: periosteal perimeter	1.1	1.8	7.0	0.0	-2.3	0.6	-2.7	0.1	-0.9	-0.1	0.7	1.7
Bone: post-yield work	0.2	0.2	0.8	0.0	-0.8	-0.0	0.1	0.9	-0.4	-0.6	0.2	0.5
Bone: stiffness	0.9	1.4	2.5	0.0	-1.3	1.3	1.6	-1.2	-0.9	1.3	1.2	1.3
Bone: tissue strength	1.5	1.5	2.9	0.0	-0.9	1.4	1.7	-0.8	-1.5	1.2	1.5	1.1
Bone: trabecular number	1.0	1.5	3.3	0.0	1.3	-1.3	-1.1	0.2	1.8	-0.7	-1.6	-1.5
Bone: trabecular spacing	0.2	0.3	0.9	0.0	-0.2	0.4	0.5	0.5	-0.9	-0.1	0.8	0.5
Bone: trabecular thickness	0.3	0.4	2.5	0.0	-0.3	-0.4	-1.6	0.1	0.5	-0.4	-0.6	-0.2
Bone: trabecular tissue density	3.4	4.7	26.0	0.0	-0.6	1.5	5.1	-2.7	-0.3	2.3	0.8	0.7
Breakpoint value in progressive ratio session	2.3	2.6	5.5	0.0	-1.3	1.9	2.3	-0.8	-2.0	1.5	2.0	1.4
Distance traveled before self-admin	1.5	1.6	6.7	0.0	0.4	0.6	2.6	-2.1	0.3	1.6	0.0	-0.2
Distance traveled after self-admin	0.8	0.8	3.0	0.0	-0.1	0.7	1.3	-1.7	-0.2	1.4	0.4	0.2
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.0	-0.2	-0.2	-0.1	0.2	0.2	-0.3	-0.2	-0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.0	0.7	0.1	0.5	-0.6	0.2	0.5	-0.1	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.2	0.5	0.0	0.5	-0.3	0.1	0.7	0.0	-0.6	-0.1	-0.4
Extinction: sum of active levers before priming	0.8	0.8	2.6	0.0	1.6	-0.6	1.1	-0.4	0.9	0.1	-0.8	-1.3
Active lever presses in extinction session 6	0.2	0.2	1.3	0.0	-0.3	0.4	1.1	-0.2	-0.3	0.3	0.3	-0.0
Delta distance traveled before/after self-admin	0.4	0.5	1.6	0.0	-0.9	0.4	-1.2	0.4	-0.8	-0.1	0.6	0.7
Delta ambulatory time before/after self-admin	0.5	0.6	1.6	0.0	-1.0	0.3	-1.3	0.9	-0.8	-0.5	0.6	0.7
Time in closed arm before self-admin	0.1	0.1	0.3	0.0	-0.2	0.3	-0.5	0.3	-0.5	-0.1	0.5	0.4
Time in closed arm after self-admin	0.4	0.4	1.3	0.0	-0.2	-0.3	-1.1	1.1	-0.4	-0.9	0.2	0.3
Time in open arm before self-admin	0.1	0.1	0.3	0.0	-0.3	-0.3	-0.6	-0.0	0.4	-0.1	-0.4	-0.2
Time in open arm after self-admin	0.2	0.2	0.8	0.0	0.2	-0.0	0.3	-0.9	0.5	0.6	-0.4	-0.2
Sum of active levers in priming session hrs 5-6	0.6	0.6	4.0	0.0	0.5	0.5	2.0	-0.3	-0.4	0.5	0.5	-0.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	0.0	-0.4	0.3	-0.8	0.7	-0.8	-0.3	0.6	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.0	-0.3	0.1	-0.6	0.7	-0.5	-0.4	0.3	0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.0	-0.2	0.4	0.4	-0.1	-0.5	0.3	0.5	0.3
Time to tail flick, test, after self-admin	2.1	2.2	5.0	0.0	-1.0	1.7	2.2	-1.5	-1.4	1.7	1.5	1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.0	0.7	-0.5	0.1	0.5	0.5	-0.5	-0.5	-0.6
Delta time to tail flick, test, before/after SA	0.7	0.6	1.4	0.0	-0.3	0.8	1.1	-1.2	-0.4	1.2	0.6	0.3
Ambulatory time before self-admin	1.3	1.4	4.4	0.0	0.8	0.2	2.0	-2.1	0.8	1.5	-0.4	-0.6
Ambulatory time after self-admin	0.2	0.2	1.2	0.0	0.1	0.1	0.4	-1.1	0.3	0.7	-0.2	-0.2
Total heroin consumption	0.4	0.5	1.0	0.0	-0.5	0.9	0.7	-0.5	-1.0	0.8	1.0	0.6
Area under the delay curve	2.1	2.2	5.5	0.0	2.4	-1.5	-0.2	1.2	1.5	-1.3	-1.5	-2.1
Delay disc. indifference point, 0s delay	2.2	2.4	3.7	0.0	1.5	-1.7	-1.2	1.8	1.4	-1.9	-1.6	-1.7
Delay disc. indifference point, 16s delay	2.1	2.1	4.7	0.0	2.2	-1.4	-1.2	1.2	1.4	-1.3	-1.4	-1.9
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	0.0	0.7	-0.1	0.8	0.2	0.1	-0.2	-0.2	-0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	0.0	0.6	-0.0	0.0	0.3	-0.0	-0.2	0.0	-0.4
Delay disc. indifference point, 4s delay	2.3	2.4	6.5	0.0	2.6	-1.5	-0.2	0.8	1.8	-1.1	-1.7	-2.3
Delay disc. indifference point, 8s delay	1.4	1.4	2.2	0.0	1.4	-1.4	-0.4	1.4	1.1	-1.5	-1.2	-1.4
Delay discount exponential model param	1.8	2.0	5.3	0.0	-2.3	1.4	0.2	-1.1	-1.4	1.2	1.4	2.0
Delay discount hyperbolic model param	1.7	1.8	5.2	0.0	-2.3	1.3	-0.0	-1.0	-1.3	1.1	1.3	1.9
Fecal boli incidents, locomotor time 1	1.5	1.6	5.4	0.0	1.1	-1.1	-2.3	1.7	0.6	-1.5	-0.6	-0.8
Change in fecal boli incidents, locomotor task	0.8	0.7	2.6	0.0	-1.6	0.8	0.2	0.0	-1.1	0.2	0.8	1.2
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.5	0.0	0.6	-0.8	-0.2	1.2	0.4	-1.1	-0.5	-0.6
Bouts of movement, locomotor time 1	1.1	1.3	2.2	0.0	1.2	-1.4	-1.2	0.5	1.5	-0.9	-1.4	-1.1
Total resting periods, locomotor time 1	0.7	0.8	1.2	0.0	1.0	-1.1	-0.9	0.6	1.0	-0.8	-1.0	-0.9
Rest time, locomotor task time 1	1.4	1.5	2.1	0.0	1.4	-1.5	-0.8	1.1	1.3	-1.3	-1.4	-1.5
Distance moved, locomotor task time 1	0.6	0.7	1.3	0.0	-1.2	1.0	-0.0	-0.5	-1.0	0.7	1.0	1.1
Vertical activity count, locomotor time 1	1.2	1.3	2.1	0.0	-1.2	1.3	1.1	-1.4	-1.0	1.5	1.1	1.1
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.8	0.0	0.1	-0.5	0.1	0.9	0.1	-0.8	-0.2	-0.0
Bouts of movement, locomotor time 2	0.6	0.6	2.9	0.0	-0.4	0.6	1.7	-0.8	-0.5	0.8	0.5	0.5
Total resting periods, locomotor time 2	0.4	0.4	2.0	0.0	-0.2	0.5	1.4	-0.5	-0.4	0.5	0.4	0.4
Rest time, locomotor task time 2	1.6	1.9	4.2	0.0	1.1	-1.4	-2.1	1.8	0.9	-1.7	-1.1	-1.1
Distance moved, locomotor task time 2	0.1	0.1	0.7	0.0	-0.1	-0.1	0.8	-0.2	0.2	0.1	-0.1	-0.1
Vertical activity count, locomotor time 2	0.3	0.4	1.1	0.0	-0.4	0.5	1.0	-1.0	-0.1	0.8	0.2	0.2
Weight adjusted by age	1.0	1.2	1.9	0.0	1.2	-1.4	-0.9	0.6	1.3	-1.0	-1.3	-1.2
Seeking ratio, delayed vs. immediate footshock	1.3	1.4	2.2	0.0	-1.4	1.3	0.7	-1.4	-1.1	1.5	1.1	1.5
Locomotion in novel chamber	0.6	0.8	2.6	0.0	-1.6	0.8	0.6	0.3	-1.1	0.1	0.9	1.2
Locomotion in novel chamber post-restriction	0.1	0.1	0.4	0.0	-0.2	0.4	0.6	-0.1	-0.3	0.3	0.3	0.2
Progressive ratio	1.0	1.1	3.0	0.0	1.1	-0.6	0.8	-1.7	1.5	0.7	-1.1	-1.0
Food seeking constrained by brief footshock	0.3	0.4	2.2	0.0	-1.5	0.1	-0.9	-0.3	0.1	0.0	-0.3	0.7
Seeking ratio, punishment vs. effort	1.0	1.2	3.3	0.0	-1.8	0.5	-1.2	1.3	-1.2	-0.6	0.9	1.3
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.0	-0.1	0.4	-0.1	-0.2	-0.4	0.2	0.4	0.2
Run reversals in cocaine runway, males	0.3	0.2	0.8	0.0	-0.4	-0.3	-0.9	0.8	-0.1	-0.7	-0.1	0.3
Latency to leave start box in cocaine runway	0.3	0.4	1.1	0.0	-1.0	0.6	-0.4	-0.4	-0.6	0.5	0.6	0.8
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.0	-0.6	0.4	-0.7	-0.2	-0.4	0.4	0.5	0.6
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.2	-0.0	-0.2	-0.0	-0.0
Cd content in liver	1.9	2.0	6.4	0.0	0.3	-1.3	-2.5	2.3	0.3	-2.0	-0.7	-0.4
Co content in liver	0.8	1.0	2.9	0.0	0.6	-1.1	-1.7	0.7	1.0	-1.0	-1.1	-0.8
Cu content in liver	0.6	0.7	3.6	0.0	-0.7	0.0	-1.9	0.9	-0.6	-0.5	0.4	0.6
Fe content in liver	0.6	0.7	1.6	0.0	0.7	-1.0	-0.3	1.3	0.7	-1.2	-0.8	-0.6
K content in liver	0.7	0.7	1.9	0.0	0.3	-0.4	1.0	-1.2	1.4	0.5	-1.0	-0.5
Mg content in liver	0.4	0.4	2.4	0.0	-0.4	-0.4	-1.5	0.3	0.4	-0.4	-0.5	0.2
Mn content in liver	1.9	2.2	5.6	0.0	-0.5	1.7	1.4	-2.4	-0.9	2.3	1.3	0.9
Na content in liver	0.3	0.3	1.8	0.0	-0.9	-0.2	-1.3	0.1	0.1	-0.2	-0.2	0.5
Rb content in liver	3.7	4.6	8.4	0.0	1.4	-2.6	-2.9	2.1	2.1	-2.5	-2.4	-1.9
Se content in liver	0.4	0.4	0.6	0.0	-0.7	0.8	0.3	-0.7	-0.6	0.8	0.7	0.8
Sr content in liver	0.3	0.3	0.5	0.0	0.7	-0.4	0.6	0.7	0.1	-0.6	-0.3	-0.6
Zn content in liver	2.9	3.1	9.1	0.0	1.0	-2.0	-3.0	1.8	1.6	-2.0	-1.8	-1.2