Hub : Genes

Kcnj2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000064933 0.08 0.04 6.8e-08 0.02 0.07 0.07 0.07 3.2e-03 1.4e-08 1.7e-08 1.4e-08
2 Adipose mRNA stability ENSRNOG00000064933 0.03 0.01 1.3e-03 0.02 0.01 0.01 0.01 3.9e-03 6.8e-03 2.1e-02 2.0e-02
3 BLA gene expression ENSRNOG00000064933 0.14 0.07 3.9e-05 0.01 0.07 0.07 0.06 7.4e-02 1.1e-04 9.0e-05 2.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.37.413.80.0-2.9-3.7
BMI without tail2.24.710.5-0.2-1.9-3.2
Body weight0.93.97.50.4-2.0-2.7
Epididymis fat weight1.02.44.7-0.2-1.6-2.2
Glucose0.40.71.41.20.7-0.3
Heart weight1.01.42.0-1.0-1.4-1.1
Left kidney weight0.00.00.00.10.2-0.1
Right kidney weight0.10.30.30.50.60.5
Tail length0.10.20.4-0.3-0.1-0.6
Length with tail0.00.00.0-0.00.1-0.2
Length without tail0.10.10.30.50.10.4
Liver weight, left1.11.83.01.71.50.5
Liver weight, right0.50.81.41.20.8-0.5
Parametrial fat weight1.02.04.31.32.10.2
Retroperitoneal fat weight0.51.82.8-1.1-1.7-1.2
Intraocular pressure0.10.10.30.5-0.30.0
Extensor digitorum longus weight0.00.10.10.4-0.2-0.3
Soleus weight0.30.81.91.40.6-0.4
Tibialis anterior weight0.20.61.20.50.71.1
Tibia length0.10.30.5-0.1-0.7-0.6
Number of licking bursts0.60.71.71.30.50.3
Food consumed during 24 hour testing period0.60.71.1-0.90.41.1
Times rat made contact with spout0.80.91.7-1.3-0.9-0.5
Mean time between licks in bursts0.50.71.40.50.61.2
Mean num. licks in bursts0.81.02.0-1.4-0.7-0.6
Std. dev. time between licks in bursts0.40.51.5-1.2-0.3-0.0
Water consumed over 24 hours0.00.10.1-0.3-0.10.2
Indifference point 0 sec1.72.73.8-1.9-1.9-0.8
Indifference point AUC0.50.50.7-0.6-0.7-0.9
Indifference point function ln k0.10.10.3-0.0-0.30.6
Indifference point function log k0.10.10.3-0.0-0.30.6
Delay discounting total patch changes 0 sec1.52.43.3-1.7-1.8-1.0
Delay discounting total patch changes 12 sec1.52.02.5-1.3-1.6-1.3
Delay discounting total patch changes 18 sec3.44.55.8-2.4-2.3-1.6
Delay discounting total patch changes 24 sec0.40.50.6-0.7-0.8-0.6
Delay discounting total patch changes 6 sec3.45.26.8-2.6-2.4-1.7
Delay discounting time to switch 0 sec0.81.21.90.71.41.1
Delay discounting water rate 0 sec2.43.95.1-1.3-2.2-2.3
Delay discounting water rate 12 sec0.50.81.8-0.1-1.4-0.8
Delay discounting water rate 18 sec0.60.92.2-0.4-1.5-0.4
Delay discounting water rate 24 sec0.60.81.7-1.3-0.5-0.6
Delay discounting water rate 6 sec0.60.92.1-0.6-1.5-0.5
Locomotor activity0.20.40.90.1-0.9-0.4
Locomotor testing distance1.01.63.9-0.2-2.0-0.9
Locomotor testing rearing4.97.612.5-2.1-3.5-2.4
Light reinforcement 10.40.61.00.8-0.6-1.0
Light reinforcement 22.02.76.62.61.1-0.1
Reaction time number correct1.21.82.70.61.61.5
Reaction time mean minus median0.91.22.6-0.21.01.6
Reaction time mean minus median AUC2.63.34.41.32.12.0
Reaction time num false alarms0.60.92.21.50.6-0.1
Reaction time num false alarms AUC1.21.72.51.61.40.7
Reaction time trials correct on left1.21.82.70.61.61.5
Reaction time trials on left1.42.03.00.71.71.6
Reaction time mean0.70.92.5-0.40.31.6
Reaction time mean AUC0.91.13.1-0.30.41.8
Median of all reaction times0.50.61.7-0.50.01.3
Reaction time omissions2.73.76.50.62.02.5
Reaction time false alarm rate0.20.30.70.80.2-0.3
Reaction time premature initiation rate4.45.98.1-1.4-2.9-2.7
Reaction time premature initiations1.01.52.2-0.7-1.3-1.5
Std. dev. reaction times1.01.33.00.01.01.7
Reaction time trials completed1.42.03.00.71.71.6
Reaction time trials AUC1.31.92.70.71.61.6
Social response proportion1.51.64.02.00.9-0.3
Social responses0.10.10.2-0.1-0.40.5
Social time0.30.40.91.00.1-0.6
Conditioned locomotion0.81.02.60.4-0.4-1.6
Cocaine response after cond. corrected0.20.30.50.40.2-0.7
Cocaine response after cond. not corrected0.10.20.30.60.2-0.3
Cocaine response before conditioning0.10.20.40.3-0.20.6
Saline control response1.41.94.4-0.5-1.1-2.1
Condit. Reinf. active minus inactive responses0.10.10.30.20.60.2
Condit. Reinf. active-inactive response ratio0.10.10.2-0.5-0.10.1
Condit. Reinf. active responses0.40.61.20.61.10.5
Condit. Reinf. inactive responses0.40.60.60.80.80.7
Condit. Reinf. lever presses0.30.40.5-0.70.50.7
Condit. Reinf. lever reinforcers received0.40.61.20.61.10.3
Pavlov. Cond. lever latency0.91.32.0-0.5-1.3-1.4
Pavlov. Cond. magazine entry latency0.30.30.6-0.40.80.4
Pavlov. Cond. change in total contacts0.91.31.9-0.21.41.3
Pavlov. Cond. index score0.71.01.70.21.31.1
Pavlov. Cond. latency score0.81.01.60.41.31.1
Pavlov. Cond. lever contacts0.71.01.40.21.21.2
Pavlov. Cond. magazine entry number0.10.20.30.5-0.5-0.1
Pavlov. Cond. intertrial magazine entries2.83.66.01.92.41.2
Pavlov. Cond. lever-magazine prob. diff.0.81.12.00.11.41.1
Pavlov. Cond. response bias0.70.91.90.01.40.9
Conditioned reinforcement - actives2.52.43.50.71.91.8
Conditioned reinforcement - inactives0.50.61.3-0.50.31.1
Conditioned locomotion0.20.20.30.20.60.5
Intermittent access intake day 1-15 change0.20.20.5-0.40.0-0.7
Intermittent access intake escalation0.30.30.5-0.50.0-0.7
Intermittent access intake escalation 20.50.50.9-1.0-0.3-0.8
Intermitt. access day 1 inactive lever presses0.60.61.5-0.6-1.2-0.2
Intermitt. access day 15 inactive lever presses0.30.30.7-0.4-0.8-0.4
Intermitt. access escalation Index0.10.10.4-0.60.0-0.1
Intermittent access day 1 total infusions0.60.71.11.10.80.6
Intermittent access day 15 total infusions0.30.30.60.60.80.1
Intermittent access terminal intake (last 3 days)0.80.81.50.61.20.8
Intermittent access total infusions0.50.51.01.00.70.5
Intermittent access day 1 locomotion0.10.10.20.1-0.40.2
Intermittent access day 15 total locomotion0.70.81.0-0.7-0.9-1.0
Intermittent access total locomotion0.30.40.9-0.0-0.9-0.4
Intermittent access standard deviation0.40.41.10.40.0-1.0
Cocaine induced anxiety0.70.81.0-0.7-0.9-1.0
Post-drug Anxiety0.00.10.1-0.4-0.10.0
Baseline Anxiety0.91.01.60.51.01.3
Lifetime Intake0.91.01.11.11.00.9
Incentive Sensitization - Responses0.10.10.40.00.20.6
Incentive Sensitization - Breakpoint0.10.10.2-0.10.10.4
Progressive ratio test 1 active lever presses0.20.20.60.2-0.8-0.3
Progressive ratio test 1 breakpoint0.20.20.60.3-0.8-0.2
Progressive ratio test 1 inactive lever presses0.10.10.4-0.10.20.6
Progressive ratio test 2 active lever presses0.10.10.10.3-0.00.3
Progressive ratio test 2 breakpoint0.10.10.30.1-0.60.1
Progressive ratio test 2 inactive lever presses0.10.10.20.30.5-0.1
Total sessions with >9 infusions0.10.10.20.50.00.1
Short access day 1 total inactive lever presses0.50.51.00.70.31.0
Short access day 10 total inactive lever presses0.20.20.3-0.6-0.30.5
Short access day 1 total infusions0.80.91.01.01.00.8
Short access day 10 total infusions0.70.71.61.30.50.5
Short access total infusions1.01.11.50.91.01.2
Short access day 1 locomotion0.40.41.0-0.2-1.0-0.3
Short access day 10 total locomotion0.20.20.40.2-0.7-0.4
Short access total locomotion0.10.10.4-0.1-0.6-0.1
Compulsive drug intake0.00.00.00.20.20.2
One hour access (0.3 mA shock)0.40.50.80.50.70.9
One hour access (shock baseline)1.21.42.30.81.51.1
Number of responses in last shaping day2.12.13.2-1.2-1.8-1.3
Context. condit. distance diff. score0.40.50.7-0.5-0.8-0.9
Locomotion velocity, session 10.30.30.50.70.40.5
Locomotion distance, session 10.30.40.9-0.0-1.0-0.5
Locomotion velocity, session 20.50.60.9-0.9-0.00.9
Locomotion distance, session 20.10.10.20.20.10.5
Locomotion velocity, session 30.40.40.60.6-0.5-0.8
Locomotion distance, session 30.40.51.01.00.6-0.1
Stereotopy head waving bouts, day 30.10.10.30.60.10.2
Stereotopy head waving duration, day 30.20.30.60.40.30.8
Locomotion velocity, session 71.21.42.60.61.11.6
Locomotion distance, session 70.91.11.21.11.11.0
Stereotopy head waving bouts, day 70.40.51.1-0.3-0.51.0
Stereotopy head waving duration, day 70.80.92.80.00.11.7
Locomotion velocity, session 80.50.61.10.41.10.7
Locomotion distance, session 80.00.10.1-0.1-0.3-0.3
Degree of sensitization distance0.40.41.0-0.10.41.0
Degree of sensitization stereotypy0.40.50.7-0.6-0.80.6
Condit. Reinf. active minus inactive responses0.20.20.60.0-0.4-0.8
Condit. Reinf. active-inactive response ratio0.10.10.20.20.50.3
Condit. Reinf. active responses0.40.50.9-0.0-0.8-1.0
Condit. Reinf. inactive responses0.40.50.80.2-0.9-0.8
Incentive salience index mean0.00.00.1-0.1-0.3-0.2
Condit. Reinf. lever presses0.30.50.8-0.9-0.7-0.2
Time in familiar zone, hab. session 10.50.41.3-1.20.0-0.0
Time in novel zone, hab. session 10.50.51.31.1-0.4-0.2
Total zone transitions, hab. session 10.30.40.9-0.5-0.9-0.3
Total locomotion distance, hab. session 10.50.81.3-0.3-1.1-1.0
Locomotion velocity, hab. session 10.30.40.70.2-0.8-0.8
Time in familiar zone, hab. session 20.60.61.4-1.2-0.4-0.5
Time in novel zone, hab. session 22.62.64.12.01.31.4
Total zone transitions, hab. session 20.20.20.4-0.6-0.5-0.1
Total locomotion distance, hab. session 20.30.40.5-0.5-0.7-0.7
Locomotion velocity, hab. session 20.30.40.7-0.3-0.6-0.8
Novel to familiar place preference ratio0.10.10.10.3-0.3-0.1
Novelty place preference0.10.10.20.4-0.10.2
Time in novel zone, NPP test0.10.10.10.3-0.20.2
Total zone transitions, NPP test0.50.70.9-0.9-1.0-0.5
Total locomotion distance, NPP test1.42.02.9-0.5-1.7-1.7
Locomotion velocity, NPP test1.92.74.5-0.4-1.8-2.1
Pavlov. Cond. lever latency1.72.23.81.62.00.6
Pavlov. Cond. magazine entry latency1.01.21.5-1.2-1.0-1.1
Pavlov. Cond. change in total contacts1.92.12.9-1.7-1.7-0.6
Pavlov. Cond. index score1.11.42.1-1.1-1.5-1.0
Pavlov. Cond. latency score1.11.42.3-1.2-1.5-0.8
Pavlov. Cond. lever contacts1.51.82.7-1.4-1.6-0.7
Pavlov. Cond. magazine entry number0.91.11.31.11.10.9
Pavlov. Cond. intertrial magazine entries0.00.10.10.3-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.81.01.4-0.8-1.2-1.0
Pavlov. Cond. response bias1.01.31.4-1.1-1.2-1.1
Bone: apparent density2.74.57.60.12.52.8
Bone surface8.615.222.82.54.84.0
Bone volume6.310.717.22.04.23.3
Bone: connectivity density3.55.58.50.82.72.9
Bone: cortical apparent density3.54.59.8-1.7-3.1-0.9
Bone: cortical area0.30.51.41.2-0.1-0.1
Bone: cortical porosity1.31.52.2-0.21.51.5
Bone: cortical porosity0.91.02.0-0.11.41.0
Bone: cortical thickness8.614.223.5-3.2-4.8-3.0
Bone: cortical thickness2.42.85.0-0.2-2.2-1.9
Bone: cortical tissue density3.34.39.2-1.7-3.0-0.9
Bone: elastic displacement3.23.67.2-1.4-2.7-1.3
Bone: elastic work0.81.02.2-0.3-1.5-0.9
Bone: endosteal estimation15.132.644.46.36.73.7
Bone: endosteal perimeter15.030.939.26.16.34.0
Bone: final force1.32.23.92.01.40.8
Bone: final moment0.81.42.41.51.10.8
Bone: marrow area14.831.843.26.36.63.5
Bone: maximum diameter8.215.118.84.34.23.0
Bone: maximum force2.03.54.92.12.21.1
Bone: maximum moment1.32.33.21.61.81.0
Bone: minimum diameter8.515.723.24.84.22.4
Bone: periosteal estimation8.116.624.34.94.52.3
Bone: periosteal perimeter5.89.611.83.43.42.3
Bone: post-yield work4.15.511.12.23.30.8
Bone: stiffness3.14.96.62.62.61.2
Bone: tissue strength1.31.32.5-1.6-1.0-0.6
Bone: trabecular number2.64.06.80.52.62.2
Bone: trabecular spacing4.15.38.1-1.5-2.8-2.4
Bone: trabecular thickness1.92.23.71.11.91.4
Bone: trabecular tissue density0.70.91.3-0.9-1.1-0.8
Breakpoint value in progressive ratio session1.71.93.51.01.21.9
Distance traveled before self-admin0.60.70.8-0.7-0.9-0.8
Distance traveled after self-admin0.30.30.5-0.7-0.5-0.5
Delta time in closed arm before/after self-admin0.10.10.1-0.3-0.30.0
Delta time in open arm before/after self-admin1.61.52.70.41.31.7
Diff in mean of infusions in LGA sessions0.30.30.90.2-0.9-0.3
Extinction: sum of active levers before priming2.93.05.10.91.72.3
Active lever presses in extinction session 62.52.43.90.91.62.0
Delta distance traveled before/after self-admin0.10.10.4-0.6-0.20.0
Delta ambulatory time before/after self-admin0.10.10.2-0.20.20.4
Time in closed arm before self-admin0.10.10.10.0-0.2-0.4
Time in closed arm after self-admin0.80.81.7-0.7-1.3-0.6
Time in open arm before self-admin0.30.30.6-0.3-0.8-0.5
Time in open arm after self-admin1.01.11.60.51.21.3
Sum of active levers in priming session hrs 5-60.60.51.0-0.2-1.0-0.7
Time to tail flick, vehicle, before self-admin1.61.63.4-0.7-1.8-1.0
Time to tail flick, vehicle, after self-admin0.30.30.50.70.4-0.5
Time to tail flick, test, before self-admin0.10.10.20.1-0.40.3
Time to tail flick, test, after self-admin1.11.22.40.60.91.5
Delta time to tail flick, vehicle, before/after SA2.42.33.71.31.91.3
Delta time to tail flick, test, before/after SA1.11.02.00.51.40.8
Ambulatory time before self-admin0.80.81.0-0.7-1.0-1.0
Ambulatory time after self-admin0.30.40.6-0.8-0.6-0.3
Total heroin consumption3.44.14.82.01.92.2
Area under the delay curve0.30.30.70.10.5-0.8
Delay disc. indifference point, 0s delay0.20.20.3-0.4-0.6-0.4
Delay disc. indifference point, 16s delay0.20.20.50.30.7-0.2
Delay disc. indifference point, 2s delay0.10.10.30.10.6-0.3
Delay disc. indifference point, 24s delay0.50.51.40.21.2-0.0
Delay disc. indifference point, 4s delay0.60.71.90.3-0.2-1.4
Delay disc. indifference point, 8s delay0.70.82.2-0.2-0.2-1.5
Delay discount exponential model param0.30.30.7-0.1-0.60.8
Delay discount hyperbolic model param0.30.40.8-0.1-0.50.9
Fecal boli incidents, locomotor time 10.60.61.7-0.01.30.4
Change in fecal boli incidents, locomotor task1.91.83.0-1.7-1.5-0.4
Time >=10cm from walls, locomotor time 11.51.52.01.01.41.2
Bouts of movement, locomotor time 11.51.72.1-1.5-1.3-1.1
Total resting periods, locomotor time 10.80.91.2-1.1-0.6-1.0
Rest time, locomotor task time 10.91.02.1-1.4-0.6-0.7
Distance moved, locomotor task time 10.91.02.71.6-0.5-0.2
Vertical activity count, locomotor time 10.80.82.01.4-0.40.6
Time >=10cm from walls, locomotor time 21.51.62.6-1.5-1.6-0.2
Bouts of movement, locomotor time 20.20.20.5-0.7-0.3-0.1
Total resting periods, locomotor time 20.30.30.8-0.9-0.3-0.3
Rest time, locomotor task time 20.60.72.0-0.11.40.3
Distance moved, locomotor task time 21.11.32.50.8-1.6-0.8
Vertical activity count, locomotor time 20.50.51.60.2-1.3-0.1
Weight adjusted by age1.01.11.60.7-1.3-1.1
Seeking ratio, delayed vs. immediate footshock2.02.33.6-1.2-1.4-1.9
Locomotion in novel chamber0.60.71.5-0.10.81.2
Locomotion in novel chamber post-restriction0.50.61.2-1.10.40.6
Progressive ratio2.42.85.21.32.31.3
Food seeking constrained by brief footshock0.20.20.5-0.70.5-0.1
Seeking ratio, punishment vs. effort1.41.82.5-1.3-1.6-1.1
Run reversals in cocaine runway, females4.74.78.8-0.9-2.1-3.0
Run reversals in cocaine runway, males0.90.91.81.3-0.3-0.9
Latency to leave start box in cocaine runway0.20.20.30.5-0.4-0.3
Latency to leave start box in cocaine runway, F1.21.42.00.7-1.3-1.4
Latency to leave start box in cocaine runway, M0.20.20.5-0.40.20.7
Cd content in liver0.10.10.1-0.2-0.4-0.1
Co content in liver1.72.03.0-1.7-1.70.0
Cu content in liver0.60.71.30.71.20.4
Fe content in liver0.30.40.6-0.70.20.8
K content in liver3.83.85.62.02.41.4
Mg content in liver2.62.63.71.51.91.4
Mn content in liver2.93.35.21.12.31.9
Na content in liver2.52.63.70.91.91.8
Rb content in liver0.81.02.01.00.2-1.4
Se content in liver0.81.01.51.01.2-0.8
Sr content in liver1.91.73.1-1.8-0.51.3
Zn content in liver2.73.04.70.91.92.2