| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | gene expression | ENSRNOG00000064401 | 0.2395 | 0.0969 | 4.8e-15 | 0.217 | 0.235 | 0.221 | 0.224 | 7.3e-12 | 8.0e-13 | 4.8e-12 | 3.4e-12 |
| 2 | BLA | intron excision ratio | chr7:113439450:113439717 | 0.0830 | 0.0540 | 2.0e-03 | 0.032 | 0.050 | 0.036 | 0.035 | 7.7e-03 | 1.1e-03 | 5.1e-03 | 5.5e-03 |
| 3 | BLA | intron excision ratio | chr7:113449412:113451873 | 0.0610 | 0.0370 | 1.4e-03 | 0.034 | 0.048 | 0.037 | 0.034 | 6.5e-03 | 1.4e-03 | 4.4e-03 | 6.5e-03 |
| 4 | Brain | gene expression | ENSRNOG00000064401 | 0.2200 | 0.0780 | 0.0e+00 | 0.352 | 0.350 | 0.356 | 0.355 | 8.6e-34 | 1.5e-33 | 2.8e-34 | 3.2e-34 |
| 5 | Brain | isoform ratio | ENSRNOT00000116109 | 0.0239 | 0.0172 | 6.9e-03 | 0.008 | 0.015 | 0.015 | 0.010 | 5.8e-02 | 1.4e-02 | 1.5e-02 | 3.6e-02 |
| 6 | Brain | intron excision ratio | chr7:113439450:113439717 | 0.0312 | 0.0242 | 4.8e-03 | 0.009 | 0.012 | 0.002 | 0.004 | 4.7e-02 | 2.5e-02 | 1.8e-01 | 1.2e-01 |
| 7 | IL | gene expression | ENSRNOG00000064401 | 0.3640 | 0.1390 | 3.7e-07 | 0.132 | 0.206 | 0.181 | 0.177 | 4.7e-04 | 1.1e-05 | 4.0e-05 | 5.0e-05 |
| 8 | LHb | gene expression | ENSRNOG00000064401 | 0.4911 | 0.1343 | 1.5e-09 | 0.344 | 0.305 | 0.232 | 0.275 | 5.2e-09 | 5.4e-08 | 3.1e-06 | 3.0e-07 |
| 9 | NAcc | gene expression | ENSRNOG00000064401 | 0.1700 | 0.0720 | 2.2e-16 | 0.210 | 0.196 | 0.197 | 0.197 | 1.3e-15 | 1.6e-14 | 1.2e-14 | 1.2e-14 |
| 10 | OFC | gene expression | ENSRNOG00000064401 | 0.2530 | 0.1154 | 8.1e-05 | 0.175 | 0.114 | 0.112 | 0.140 | 6.1e-05 | 1.2e-03 | 1.3e-03 | 3.5e-04 |
| 11 | PL | gene expression | ENSRNOG00000064401 | 0.2240 | 0.0875 | 0.0e+00 | 0.225 | 0.224 | 0.196 | 0.220 | 5.1e-17 | 5.6e-17 | 7.9e-15 | 1.2e-16 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Right kidney weight | 14.2 | 40.5 | 48.8 | -6.5 | 5.2 | -6.1 | -6.9 | 6.6 | 5.8 | -6.0 | -6.8 | -7.0 | -6.3 | -6.5 |
| Left kidney weight | 12.8 | 36.7 | 43.7 | -6.1 | 4.7 | -5.7 | -6.6 | 6.1 | 5.7 | -5.8 | -6.5 | -6.6 | -6.3 | -6.2 |
| Context. condit. distance diff. score | 6.2 | 7.6 | 11.2 | -2.6 | 1.2 | -2.0 | -3.2 | 2.3 | 3.3 | -3.2 | -3.0 | -3.0 | -2.9 | -2.9 |
| Time in closed arm before self-admin | 5.4 | 6.2 | 9.6 | 2.3 | -1.1 | 2.0 | 2.6 | -2.6 | -2.5 | 3.1 | 2.8 | 2.6 | 2.4 | 2.8 |
| Cu content in liver | 4.2 | 5.0 | 6.4 | 2.2 | -1.4 | 1.9 | 2.5 | -2.2 | -2.3 | 2.4 | 2.4 | 2.5 | 2.4 | 2.3 |
| Retroperitoneal fat weight | 4.1 | 13.6 | 20.6 | -3.4 | 2.2 | -3.1 | -3.8 | 3.4 | 4.1 | -3.9 | -4.0 | -3.8 | -4.5 | -3.8 |
| Bone: maximum diameter | 3.8 | 7.0 | 9.4 | -2.7 | 1.9 | -2.3 | -3.1 | 2.5 | 2.6 | -2.6 | -2.8 | -3.0 | -2.7 | -2.8 |
| Short access total infusions | 3.7 | 4.1 | 6.4 | -2.2 | 2.5 | -2.4 | -1.9 | 2.3 | 1.4 | -1.2 | -2.1 | -2.1 | -1.4 | -2.1 |
| Total zone transitions, hab. session 1 | 3.7 | 5.2 | 6.3 | 2.5 | -2.4 | 2.4 | 2.4 | -2.0 | -2.4 | 1.5 | 2.4 | 2.3 | 2.2 | 2.3 |
| Pavlov. Cond. magazine entry latency | 3.5 | 4.0 | 8.0 | 1.5 | 0.0 | 0.8 | 2.4 | -1.4 | -2.6 | 2.8 | 2.3 | 2.3 | 1.9 | 2.1 |
| Pavlov. Cond. intertrial magazine entries | 3.4 | 4.4 | 6.2 | -2.2 | 1.8 | -2.0 | -2.3 | 2.1 | 2.0 | -2.0 | -2.1 | -2.5 | -1.8 | -2.1 |
| Bone: maximum moment | 3.4 | 5.9 | 7.1 | -2.6 | 2.6 | -2.7 | -2.5 | 2.7 | 1.8 | -1.8 | -2.5 | -2.6 | -2.5 | -2.4 |
| Epididymis fat weight | 3.3 | 7.8 | 12.1 | -2.4 | 0.8 | -1.8 | -3.0 | 2.2 | 3.5 | -3.4 | -3.1 | -2.9 | -3.2 | -3.0 |
| Degree of sensitization distance | 3.3 | 3.3 | 5.4 | -2.1 | 2.3 | -2.2 | -1.8 | 1.7 | 1.8 | -0.9 | -1.9 | -1.7 | -1.7 | -1.6 |
| Time in novel zone, NPP test | 3.3 | 3.5 | 4.9 | -1.7 | 0.7 | -1.4 | -2.1 | 1.7 | 2.1 | -2.2 | -2.0 | -1.9 | -2.2 | -1.9 |
| Bone: periosteal perimeter | 3.2 | 5.3 | 7.3 | -2.0 | 0.9 | -1.5 | -2.7 | 1.8 | 2.6 | -2.6 | -2.7 | -2.6 | -2.6 | -2.5 |
| Bone: maximum force | 3.1 | 5.4 | 6.5 | -2.5 | 2.5 | -2.5 | -2.3 | 2.6 | 1.7 | -1.7 | -2.4 | -2.5 | -2.4 | -2.3 |
| Seeking ratio, delayed vs. immediate footshock | 3.0 | 3.4 | 4.7 | 1.8 | -0.9 | 1.4 | 2.1 | -1.7 | -2.1 | 2.2 | 2.0 | 2.0 | 2.0 | 1.9 |
| Heart weight | 2.9 | 4.2 | 6.2 | -2.4 | 2.5 | -2.4 | -2.2 | 1.8 | 1.8 | -1.1 | -2.1 | -2.2 | -1.3 | -2.0 |
| Stereotopy head waving duration, day 3 | 2.9 | 3.5 | 5.2 | -1.9 | 1.3 | -1.6 | -2.3 | 1.6 | 2.0 | -1.8 | -1.9 | -2.2 | -2.0 | -1.8 |
| Total zone transitions, NPP test | 2.9 | 4.1 | 5.7 | 2.2 | -1.9 | 2.0 | 2.1 | -1.6 | -2.4 | 1.5 | 2.2 | 2.0 | 2.2 | 2.0 |
| Na content in liver | 2.9 | 3.1 | 3.9 | 1.7 | -1.1 | 1.5 | 2.0 | -1.8 | -1.7 | 1.9 | 1.8 | 2.0 | 1.8 | 1.9 |
| Pavlov. Cond. latency score | 2.8 | 3.5 | 7.4 | 1.3 | 0.3 | 0.6 | 2.1 | -1.2 | -2.6 | 2.7 | 2.1 | 2.1 | 1.8 | 2.0 |
| Delta time to tail flick, test, before/after SA | 2.8 | 2.5 | 3.8 | 1.4 | -0.8 | 1.2 | 1.7 | -1.5 | -1.8 | 1.8 | 1.6 | 1.7 | 2.0 | 1.7 |
| Short access day 1 total infusions | 2.6 | 2.8 | 4.4 | -1.9 | 2.1 | -1.9 | -1.7 | 1.9 | 1.0 | -1.0 | -1.7 | -1.8 | -0.9 | -1.7 |
| Condit. Reinf. inactive responses | 2.6 | 3.1 | 5.1 | 1.5 | -0.9 | 1.4 | 1.8 | -1.8 | -1.6 | 2.0 | 2.0 | 1.6 | 2.3 | 1.9 |
| Novelty place preference | 2.6 | 2.7 | 4.0 | -1.5 | 0.6 | -1.2 | -1.8 | 1.5 | 1.8 | -2.0 | -1.7 | -1.6 | -2.0 | -1.7 |
| Latency to leave start box in cocaine runway, M | 2.6 | 2.5 | 3.2 | -1.6 | 1.4 | -1.6 | -1.5 | 1.5 | 1.7 | -1.3 | -1.7 | -1.7 | -1.8 | -1.5 |
| Total sessions with >9 infusions | 2.5 | 2.8 | 4.0 | -1.7 | 1.9 | -1.9 | -1.6 | 2.0 | 1.1 | -1.2 | -1.7 | -1.8 | -1.4 | -1.7 |
| Locomotion distance, session 1 | 2.5 | 3.2 | 4.3 | 2.1 | -1.9 | 2.0 | 1.9 | -1.5 | -2.1 | 1.2 | 1.8 | 1.7 | 1.7 | 1.8 |
| Locomotion velocity, hab. session 1 | 2.5 | 3.5 | 5.3 | 2.1 | -2.3 | 2.2 | 1.8 | -1.8 | -1.7 | 1.1 | 1.9 | 1.7 | 1.9 | 1.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.4 | 3.1 | 6.4 | 1.3 | 0.1 | 0.7 | 2.0 | -1.2 | -2.3 | 2.5 | 2.0 | 2.0 | 1.6 | 1.9 |
| Compulsive drug intake | 2.4 | 2.4 | 3.6 | 1.6 | -1.3 | 1.4 | 1.6 | -1.1 | -1.9 | 1.2 | 1.6 | 1.5 | 1.6 | 1.6 |
| Pavlov. Cond. index score | 2.3 | 3.0 | 6.4 | 1.2 | 0.2 | 0.6 | 2.0 | -1.1 | -2.4 | 2.5 | 2.0 | 1.9 | 1.6 | 1.9 |
| Conditioned locomotion | 2.3 | 2.8 | 4.1 | -1.7 | 1.6 | -1.7 | -1.7 | 2.0 | 1.2 | -1.5 | -1.9 | -1.7 | -1.2 | -1.9 |
| Locomotion velocity, NPP test | 2.3 | 3.2 | 3.8 | 1.9 | -1.6 | 1.8 | 1.9 | -1.6 | -1.9 | 1.5 | 1.9 | 1.8 | 2.0 | 1.8 |
| Locomotion distance, session 2 | 2.2 | 3.2 | 6.1 | 1.6 | -0.5 | 1.1 | 2.0 | -1.2 | -2.5 | 2.1 | 2.0 | 1.8 | 2.0 | 1.9 |
| Total locomotion distance, hab. session 1 | 2.2 | 3.2 | 6.3 | 2.0 | -2.5 | 2.3 | 1.6 | -1.8 | -1.5 | 0.7 | 1.7 | 1.6 | 1.7 | 1.6 |
| Liver weight, right | 2.1 | 3.5 | 7.1 | -1.4 | -0.1 | -0.7 | -2.1 | 1.2 | 2.7 | -2.6 | -2.1 | -1.9 | -2.3 | -2.0 |
| Locomotion velocity, session 8 | 2.1 | 2.5 | 3.6 | -1.7 | 1.4 | -1.6 | -1.9 | 1.7 | 1.3 | -1.5 | -1.6 | -1.8 | -1.4 | -1.6 |
| Mean num. licks in bursts | 2.0 | 2.4 | 3.0 | -1.6 | 1.2 | -1.4 | -1.6 | 1.5 | 1.6 | -1.5 | -1.6 | -1.5 | -1.7 | -1.6 |
| Short access total locomotion | 2.0 | 2.1 | 3.4 | -1.6 | 1.8 | -1.6 | -1.4 | 1.5 | 1.2 | -0.8 | -1.5 | -1.7 | -0.8 | -1.5 |
| Bone: final moment | 2.0 | 3.4 | 4.8 | -1.9 | 2.2 | -2.2 | -1.7 | 2.1 | 1.1 | -1.1 | -1.9 | -1.8 | -2.0 | -1.7 |
| Bone: stiffness | 2.0 | 3.1 | 3.9 | -1.9 | 2.0 | -1.9 | -1.8 | 1.8 | 1.4 | -1.2 | -1.9 | -1.9 | -1.7 | -1.8 |
| Food consumed during 24 hour testing period | 1.9 | 2.2 | 2.8 | -1.6 | 1.6 | -1.6 | -1.5 | 1.6 | 1.2 | -1.1 | -1.4 | -1.6 | -1.7 | -1.4 |
| Bone: final force | 1.9 | 3.1 | 4.4 | -1.8 | 2.1 | -2.1 | -1.6 | 2.0 | 1.1 | -1.1 | -1.8 | -1.8 | -1.9 | -1.6 |
| Delta time in closed arm before/after self-admin | 1.9 | 1.9 | 2.5 | -1.4 | 1.3 | -1.4 | -1.4 | 1.6 | 1.1 | -1.3 | -1.3 | -1.6 | -1.0 | -1.4 |
| Stereotopy head waving bouts, day 7 | 1.8 | 2.0 | 3.6 | -1.1 | 0.0 | -0.6 | -1.7 | 1.0 | 1.7 | -1.9 | -1.4 | -1.5 | -1.7 | -1.6 |
| Novel to familiar place preference ratio | 1.8 | 1.9 | 2.7 | -1.3 | 0.5 | -1.0 | -1.5 | 1.2 | 1.5 | -1.6 | -1.4 | -1.4 | -1.6 | -1.4 |
| Bone: elastic work | 1.8 | 2.4 | 2.9 | -1.6 | 1.4 | -1.5 | -1.7 | 1.4 | 1.5 | -1.2 | -1.6 | -1.6 | -1.6 | -1.6 |
| Time to tail flick, vehicle, after self-admin | 1.8 | 1.9 | 4.6 | 1.6 | -2.1 | 1.9 | 1.1 | -1.6 | -0.7 | 0.5 | 1.3 | 1.2 | 1.0 | 1.3 |
| Food seeking constrained by brief footshock | 1.8 | 2.2 | 3.2 | -1.5 | 1.1 | -1.4 | -1.5 | 1.6 | 1.4 | -1.5 | -1.6 | -1.6 | -1.4 | -1.8 |
| BMI with tail | 1.7 | 5.6 | 6.9 | -2.6 | 2.6 | -2.5 | -2.5 | 2.3 | 2.2 | -1.7 | -2.5 | -2.6 | -2.0 | -2.3 |
| Pavlov. Cond. magazine entry number | 1.7 | 2.2 | 4.7 | -1.0 | -0.3 | -0.3 | -1.8 | 0.8 | 2.1 | -2.2 | -1.7 | -1.8 | -1.2 | -1.5 |
| Body weight | 1.6 | 6.8 | 8.4 | -2.6 | 2.1 | -2.4 | -2.7 | 2.6 | 2.6 | -2.4 | -2.7 | -2.7 | -2.9 | -2.7 |
| Locomotor activity | 1.6 | 2.5 | 3.9 | -1.5 | 0.9 | -1.3 | -1.7 | 1.4 | 1.7 | -1.6 | -1.6 | -1.8 | -2.0 | -1.6 |
| Short access day 1 total inactive lever presses | 1.6 | 1.7 | 3.2 | -1.5 | 1.8 | -1.6 | -1.3 | 1.6 | 0.6 | -0.7 | -1.3 | -1.4 | -0.6 | -1.3 |
| Bone: cortical area | 1.6 | 2.4 | 3.1 | -1.6 | 1.3 | -1.5 | -1.7 | 1.5 | 1.4 | -1.3 | -1.7 | -1.8 | -1.5 | -1.7 |
| Delay discounting water rate 18 sec | 1.5 | 2.0 | 3.5 | 1.4 | -0.7 | 1.1 | 1.5 | -1.1 | -1.9 | 1.6 | 1.6 | 1.3 | 1.3 | 1.6 |
| Locomotor testing rearing | 1.5 | 2.3 | 3.2 | -1.4 | 0.7 | -1.1 | -1.6 | 1.3 | 1.8 | -1.7 | -1.6 | -1.8 | -1.7 | -1.6 |
| Reaction time trials on left | 1.5 | 2.2 | 4.6 | 1.8 | -2.1 | 1.9 | 1.5 | -1.5 | -1.1 | 0.6 | 1.4 | 1.5 | 1.0 | 1.2 |
| Reaction time trials completed | 1.5 | 2.2 | 4.6 | 1.8 | -2.1 | 1.9 | 1.5 | -1.5 | -1.1 | 0.6 | 1.4 | 1.5 | 1.0 | 1.2 |
| Social time | 1.5 | 2.0 | 2.6 | 1.4 | -0.7 | 1.2 | 1.5 | -1.3 | -1.6 | 1.6 | 1.5 | 1.3 | 1.5 | 1.6 |
| Delay disc. indifference point, 16s delay | 1.5 | 1.5 | 2.2 | 1.3 | -0.9 | 1.1 | 1.4 | -1.0 | -1.5 | 1.1 | 1.3 | 1.4 | 1.1 | 1.3 |
| Zn content in liver | 1.5 | 1.6 | 2.0 | 1.3 | -1.1 | 1.3 | 1.3 | -1.3 | -1.2 | 1.1 | 1.4 | 1.4 | 1.3 | 1.3 |
| Reaction time number correct | 1.4 | 2.0 | 4.2 | 1.7 | -2.1 | 1.8 | 1.5 | -1.4 | -1.1 | 0.6 | 1.3 | 1.5 | 0.9 | 1.2 |
| Reaction time trials correct on left | 1.4 | 2.0 | 4.2 | 1.7 | -2.1 | 1.8 | 1.5 | -1.4 | -1.1 | 0.6 | 1.3 | 1.5 | 0.9 | 1.2 |
| Baseline Anxiety | 1.4 | 1.5 | 2.1 | 1.3 | -1.4 | 1.4 | 1.2 | -1.2 | -1.2 | 0.8 | 1.3 | 1.2 | 1.2 | 1.3 |
| Locomotion distance, session 3 | 1.4 | 1.6 | 3.8 | 1.5 | -1.9 | 1.6 | 1.3 | -1.1 | -1.0 | 0.3 | 1.1 | 1.2 | 0.9 | 1.0 |
| Total locomotion distance, NPP test | 1.4 | 2.0 | 3.0 | 1.4 | -1.1 | 1.3 | 1.5 | -1.1 | -1.7 | 1.2 | 1.5 | 1.4 | 1.6 | 1.4 |
| Bone: endosteal perimeter | 1.4 | 2.8 | 5.0 | -1.2 | -0.1 | -0.6 | -2.1 | 1.0 | 2.1 | -2.2 | -1.9 | -1.9 | -1.9 | -1.7 |
| Bone: trabecular tissue density | 1.4 | 2.0 | 4.2 | 1.0 | -0.0 | 0.7 | 1.4 | -1.3 | -1.6 | 2.0 | 1.6 | 1.2 | 1.6 | 1.8 |
| Time to tail flick, test, after self-admin | 1.4 | 1.4 | 2.5 | 1.2 | -1.1 | 1.2 | 1.2 | -1.2 | -1.1 | 1.0 | 1.2 | 1.3 | 1.6 | 1.1 |
| Length without tail | 1.3 | 2.8 | 5.1 | -1.5 | 1.3 | -1.6 | -1.6 | 2.0 | 1.3 | -1.7 | -1.7 | -1.7 | -2.2 | -1.7 |
| Intermitt. access day 15 inactive lever presses | 1.3 | 1.5 | 4.5 | -1.5 | 2.1 | -1.8 | -1.0 | 1.6 | 0.2 | -0.2 | -0.9 | -1.0 | -0.4 | -0.9 |
| Lifetime Intake | 1.3 | 1.5 | 2.4 | -1.3 | 1.6 | -1.5 | -1.0 | 1.4 | 0.7 | -0.7 | -1.3 | -1.3 | -0.7 | -1.3 |
| Stereotopy head waving duration, day 7 | 1.3 | 1.5 | 2.9 | -0.9 | -0.2 | -0.4 | -1.5 | 0.7 | 1.7 | -1.7 | -1.2 | -1.3 | -1.5 | -1.4 |
| Locomotion velocity, hab. session 2 | 1.3 | 1.8 | 2.9 | 1.2 | -0.7 | 1.1 | 1.3 | -1.1 | -1.7 | 1.4 | 1.4 | 1.4 | 1.7 | 1.4 |
| Bone: trabecular spacing | 1.3 | 1.7 | 2.4 | -1.3 | 1.4 | -1.4 | -1.2 | 1.6 | 0.9 | -1.0 | -1.3 | -1.2 | -1.4 | -1.4 |
| Std. dev. time between licks in bursts | 1.2 | 1.5 | 3.0 | 0.9 | 0.0 | 0.6 | 1.3 | -0.8 | -1.7 | 1.7 | 1.2 | 1.3 | 1.4 | 1.3 |
| Reaction time trials AUC | 1.2 | 1.7 | 3.7 | 1.6 | -1.9 | 1.7 | 1.4 | -1.3 | -1.0 | 0.5 | 1.2 | 1.3 | 0.8 | 1.1 |
| Intermittent access day 1 total infusions | 1.2 | 1.4 | 1.9 | -1.2 | 1.1 | -1.2 | -1.1 | 1.3 | 0.9 | -1.0 | -1.4 | -1.4 | -0.7 | -1.4 |
| Bone: periosteal estimation | 1.2 | 2.4 | 3.7 | -1.4 | 0.6 | -1.0 | -1.9 | 1.2 | 1.7 | -1.7 | -1.6 | -1.9 | -1.7 | -1.6 |
| Locomotion in novel chamber | 1.2 | 1.5 | 4.3 | 1.2 | -1.8 | 1.7 | 0.7 | -1.4 | -0.6 | 0.3 | 0.7 | 0.8 | 2.1 | 0.8 |
| Delay discounting water rate 6 sec | 1.1 | 1.6 | 1.9 | 1.3 | -1.3 | 1.4 | 1.3 | -1.2 | -1.3 | 1.0 | 1.3 | 1.4 | 1.2 | 1.2 |
| Pavlov. Cond. lever latency | 1.1 | 1.5 | 3.3 | -0.8 | -0.1 | -0.5 | -1.2 | 0.9 | 1.6 | -1.8 | -1.3 | -1.2 | -1.3 | -1.4 |
| Pavlov. Cond. response bias | 1.1 | 1.5 | 3.9 | 0.7 | 0.6 | 0.1 | 1.3 | -0.7 | -1.8 | 2.0 | 1.4 | 1.2 | 1.2 | 1.3 |
| Cocaine induced anxiety | 1.1 | 1.2 | 2.3 | -1.2 | 1.5 | -1.5 | -0.8 | 1.1 | 1.0 | -0.4 | -1.0 | -0.9 | -1.5 | -1.0 |
| Short access day 10 total infusions | 1.1 | 1.2 | 1.6 | -1.1 | 1.3 | -1.3 | -0.9 | 1.2 | 1.0 | -0.7 | -1.0 | -1.2 | -1.2 | -1.0 |
| Degree of sensitization stereotypy | 1.1 | 1.2 | 2.8 | -0.7 | -0.4 | -0.2 | -1.2 | 0.7 | 1.3 | -1.7 | -1.1 | -1.1 | -1.3 | -1.3 |
| Condit. Reinf. active responses | 1.1 | 1.3 | 2.5 | 0.9 | -0.2 | 0.7 | 1.2 | -1.0 | -1.3 | 1.5 | 1.3 | 0.9 | 1.6 | 1.4 |
| Bone: cortical porosity | 1.1 | 1.2 | 1.8 | -1.1 | 0.8 | -0.9 | -1.4 | 0.8 | 1.3 | -0.9 | -1.0 | -1.3 | -1.1 | -1.0 |
| Run reversals in cocaine runway, females | 1.1 | 1.1 | 2.3 | 1.2 | -1.5 | 1.4 | 0.8 | -1.0 | -0.6 | 0.3 | 0.9 | 0.9 | 1.3 | 0.8 |
| Pavlov. Cond. lever contacts | 1.0 | 1.3 | 3.4 | 0.7 | 0.4 | 0.3 | 1.1 | -0.8 | -1.6 | 1.8 | 1.3 | 1.1 | 1.2 | 1.3 |
| Progressive ratio test 1 inactive lever presses | 1.0 | 1.1 | 3.7 | -1.3 | 1.9 | -1.5 | -0.8 | 1.0 | 0.5 | 0.1 | -0.8 | -0.9 | -0.2 | -0.8 |
| Pavlov. Cond. lever contacts | 1.0 | 1.2 | 2.1 | 0.8 | -0.2 | 0.6 | 1.2 | -0.9 | -1.2 | 1.4 | 1.3 | 0.9 | 1.4 | 1.3 |
| Pavlov. Cond. intertrial magazine entries | 1.0 | 1.2 | 2.1 | 0.9 | -0.3 | 0.6 | 1.2 | -0.8 | -1.5 | 1.4 | 1.3 | 1.3 | 1.1 | 1.1 |
| Delay disc. indifference point, 0s delay | 1.0 | 1.1 | 1.6 | -1.2 | 1.1 | -1.0 | -1.2 | 0.8 | 1.3 | -0.7 | -1.0 | -1.1 | -0.8 | -1.0 |
| Locomotion in novel chamber post-restriction | 1.0 | 1.2 | 1.8 | 1.2 | -1.2 | 1.2 | 1.0 | -1.2 | -0.8 | 0.8 | 1.1 | 1.0 | 1.3 | 1.1 |
| Seeking ratio, punishment vs. effort | 1.0 | 1.2 | 1.8 | -1.0 | 0.7 | -0.9 | -1.1 | 1.2 | 0.9 | -1.1 | -1.2 | -1.2 | -1.1 | -1.3 |
| Mg content in liver | 1.0 | 1.0 | 2.7 | 0.6 | 0.5 | 0.1 | 1.1 | -0.5 | -1.5 | 1.6 | 0.9 | 1.0 | 1.2 | 1.0 |
| Times rat made contact with spout | 0.9 | 1.0 | 1.7 | -1.0 | 1.1 | -1.1 | -1.0 | 1.3 | 0.5 | -0.8 | -0.9 | -1.0 | -1.0 | -0.9 |
| Indifference point function ln k | 0.9 | 1.3 | 2.2 | -1.2 | 0.9 | -1.0 | -1.2 | 0.8 | 1.4 | -1.0 | -1.1 | -1.2 | -1.5 | -1.2 |
| Indifference point function log k | 0.9 | 1.3 | 2.2 | -1.2 | 0.9 | -1.0 | -1.2 | 0.8 | 1.4 | -1.0 | -1.1 | -1.2 | -1.5 | -1.2 |
| Pavlov. Cond. change in total contacts | 0.9 | 1.2 | 3.6 | -0.0 | 1.6 | -0.7 | 0.9 | 0.1 | -1.7 | 1.9 | 0.9 | 0.9 | 0.7 | 0.8 |
| Pavlov. Cond. lever latency | 0.9 | 1.1 | 1.7 | -0.9 | 0.3 | -0.7 | -1.1 | 0.9 | 1.2 | -1.3 | -1.2 | -0.9 | -1.3 | -1.3 |
| Se content in liver | 0.9 | 1.1 | 1.4 | 1.1 | -1.2 | 1.2 | 1.0 | -1.1 | -0.9 | 0.7 | 0.9 | 0.9 | 1.0 | 1.1 |
| Sr content in liver | 0.9 | 0.8 | 0.9 | 1.0 | -0.9 | 1.0 | 1.0 | -0.9 | -0.6 | 0.6 | 0.9 | 0.9 | 1.0 | 0.9 |
| Tibia length | 0.8 | 2.3 | 3.2 | -1.4 | 1.2 | -1.5 | -1.5 | 1.8 | 1.0 | -1.4 | -1.7 | -1.5 | -1.7 | -1.6 |
| Condit. Reinf. inactive responses | 0.8 | 1.0 | 1.8 | -0.9 | 0.4 | -0.7 | -1.3 | 1.1 | 0.9 | -1.4 | -1.1 | -1.3 | -0.8 | -1.1 |
| Intermittent access standard deviation | 0.8 | 0.9 | 1.6 | -1.1 | 1.3 | -1.2 | -0.9 | 0.9 | 0.8 | -0.5 | -1.1 | -0.8 | -0.4 | -1.1 |
| Progressive ratio test 1 active lever presses | 0.8 | 0.8 | 1.3 | -0.9 | 1.1 | -1.1 | -0.6 | 1.1 | 0.6 | -0.6 | -1.0 | -0.7 | -0.7 | -1.0 |
| Total zone transitions, hab. session 2 | 0.8 | 1.0 | 2.6 | 0.8 | -0.3 | 0.6 | 1.0 | -0.4 | -1.6 | 1.0 | 1.1 | 0.9 | 1.3 | 1.0 |
| Pavlov. Cond. change in total contacts | 0.8 | 0.9 | 2.1 | 0.6 | 0.4 | 0.2 | 1.0 | -0.3 | -1.5 | 1.4 | 0.9 | 0.7 | 1.3 | 1.0 |
| Cd content in liver | 0.8 | 0.9 | 1.6 | -0.9 | 0.3 | -0.5 | -1.2 | 0.7 | 1.2 | -1.2 | -1.1 | -1.3 | -0.8 | -0.9 |
| Water consumed over 24 hours | 0.7 | 0.8 | 1.4 | -0.9 | 0.9 | -1.0 | -1.0 | 1.2 | 0.5 | -0.8 | -0.8 | -1.0 | -1.0 | -0.8 |
| Light reinforcement 2 | 0.7 | 1.0 | 2.0 | -0.9 | 0.3 | -0.6 | -1.2 | 0.6 | 1.4 | -1.1 | -1.0 | -1.1 | -1.0 | -0.9 |
| Intermitt. access day 1 inactive lever presses | 0.7 | 0.7 | 2.9 | -1.1 | 1.7 | -1.3 | -0.6 | 0.9 | 0.1 | 0.2 | -0.5 | -0.6 | -0.2 | -0.6 |
| Stereotopy head waving bouts, day 3 | 0.7 | 0.9 | 1.3 | -1.0 | 0.8 | -0.9 | -1.0 | 0.9 | 0.8 | -0.8 | -0.9 | -1.0 | -1.1 | -0.9 |
| Locomotion distance, session 8 | 0.7 | 1.1 | 1.7 | -1.0 | 0.3 | -0.7 | -1.3 | 0.8 | 1.3 | -1.2 | -1.1 | -1.3 | -0.9 | -1.1 |
| Total locomotion distance, hab. session 2 | 0.7 | 1.0 | 1.7 | 0.8 | -0.4 | 0.7 | 1.0 | -0.7 | -1.3 | 1.1 | 1.0 | 1.0 | 1.3 | 1.0 |
| Bone: cortical thickness | 0.7 | 0.8 | 2.1 | -1.0 | 1.4 | -1.2 | -0.6 | 1.2 | 0.3 | -0.3 | -0.8 | -0.7 | -0.5 | -0.9 |
| Time in open arm after self-admin | 0.7 | 0.8 | 2.5 | 1.0 | -1.6 | 1.2 | 0.7 | -1.1 | -0.2 | 0.2 | 0.6 | 0.8 | 0.7 | 0.6 |
| Rest time, locomotor task time 1 | 0.7 | 0.7 | 1.4 | -0.9 | 1.2 | -1.0 | -0.7 | 0.9 | 0.6 | -0.3 | -0.8 | -0.8 | -1.1 | -0.7 |
| Distance moved, locomotor task time 2 | 0.7 | 0.8 | 1.8 | -0.9 | 0.3 | -0.5 | -1.2 | 0.5 | 1.4 | -1.1 | -0.9 | -1.1 | -0.6 | -1.0 |
| Liver weight, left | 0.6 | 1.0 | 2.1 | -0.6 | -0.3 | -0.2 | -1.1 | 0.5 | 1.4 | -1.5 | -1.0 | -1.0 | -1.1 | -1.1 |
| Reaction time mean minus median AUC | 0.6 | 0.8 | 1.8 | -0.8 | 0.2 | -0.5 | -1.0 | 0.5 | 1.4 | -1.0 | -0.8 | -1.1 | -1.1 | -1.0 |
| Intermittent access day 1 locomotion | 0.6 | 0.6 | 0.9 | -0.9 | 1.0 | -0.9 | -0.7 | 0.8 | 0.6 | -0.4 | -0.9 | -0.9 | -0.3 | -0.9 |
| Intermittent access total locomotion | 0.6 | 0.7 | 1.1 | -0.9 | 1.0 | -1.0 | -0.7 | 1.0 | 0.6 | -0.5 | -1.0 | -0.8 | -0.7 | -1.0 |
| Number of responses in last shaping day | 0.6 | 0.6 | 1.9 | 0.2 | 0.9 | -0.2 | 0.7 | -0.3 | -1.1 | 1.4 | 0.8 | 0.6 | 0.9 | 0.8 |
| Condit. Reinf. lever presses | 0.6 | 0.8 | 1.7 | 0.7 | -0.1 | 0.5 | 0.8 | -0.7 | -1.0 | 1.1 | 1.0 | 0.7 | 1.3 | 1.0 |
| Delta time in open arm before/after self-admin | 0.6 | 0.5 | 1.1 | 0.8 | -1.1 | 1.0 | 0.6 | -1.0 | -0.3 | 0.4 | 0.6 | 0.6 | 0.8 | 0.5 |
| K content in liver | 0.6 | 0.6 | 1.4 | 0.5 | 0.3 | 0.1 | 0.8 | -0.4 | -1.2 | 1.2 | 0.8 | 0.8 | 0.9 | 0.9 |
| Tibialis anterior weight | 0.5 | 1.8 | 2.9 | 1.1 | -0.2 | 0.7 | 1.5 | -1.1 | -1.6 | 1.7 | 1.5 | 1.6 | 1.6 | 1.5 |
| Mean time between licks in bursts | 0.5 | 0.6 | 0.8 | 0.8 | -0.5 | 0.7 | 0.9 | -0.9 | -0.7 | 0.9 | 0.7 | 0.9 | 0.9 | 0.8 |
| Delay discounting total patch changes 0 sec | 0.5 | 0.9 | 2.1 | 0.5 | 0.3 | 0.3 | 0.9 | -0.7 | -1.2 | 1.5 | 0.9 | 0.9 | 1.3 | 0.9 |
| Reaction time premature initiations | 0.5 | 0.7 | 1.3 | 0.7 | -0.1 | 0.4 | 0.9 | -0.5 | -1.1 | 1.1 | 1.0 | 0.9 | 0.7 | 0.9 |
| Conditioned locomotion | 0.5 | 0.6 | 1.4 | -0.5 | -0.2 | -0.2 | -1.0 | 0.4 | 1.2 | -1.2 | -0.7 | -0.9 | -0.7 | -0.8 |
| Condit. Reinf. active responses | 0.5 | 0.7 | 1.5 | -0.9 | 0.9 | -1.0 | -0.8 | 1.2 | 0.2 | -0.7 | -0.7 | -0.8 | -0.5 | -0.9 |
| Intermittent access intake escalation | 0.5 | 0.5 | 1.0 | 0.6 | -0.3 | 0.5 | 0.8 | -0.5 | -0.7 | 0.7 | 0.6 | 1.0 | 1.0 | 0.6 |
| Progressive ratio test 1 breakpoint | 0.5 | 0.5 | 0.8 | -0.7 | 0.7 | -0.8 | -0.5 | 0.9 | 0.5 | -0.6 | -0.8 | -0.6 | -0.7 | -0.8 |
| Pavlov. Cond. magazine entry latency | 0.5 | 0.7 | 1.3 | 0.6 | 0.2 | 0.3 | 1.0 | -0.4 | -1.1 | 1.1 | 0.8 | 0.7 | 0.9 | 1.0 |
| Pavlov. Cond. response bias | 0.5 | 0.6 | 1.2 | 0.5 | 0.2 | 0.2 | 0.9 | -0.4 | -1.0 | 1.1 | 0.8 | 0.6 | 0.9 | 1.0 |
| Bone: cortical apparent density | 0.5 | 0.7 | 1.2 | 0.8 | -0.5 | 0.7 | 1.0 | -0.6 | -1.1 | 0.8 | 0.9 | 0.9 | 1.0 | 0.8 |
| Bone: cortical thickness | 0.5 | 0.8 | 2.2 | -1.0 | 1.5 | -1.3 | -0.6 | 1.1 | 0.2 | -0.1 | -0.7 | -0.7 | -0.6 | -0.8 |
| Bone: cortical tissue density | 0.5 | 0.6 | 1.1 | 0.8 | -0.5 | 0.6 | 0.9 | -0.5 | -1.1 | 0.8 | 0.8 | 0.8 | 1.0 | 0.8 |
| Bone: endosteal estimation | 0.5 | 1.0 | 2.0 | -0.7 | -0.3 | -0.2 | -1.4 | 0.5 | 1.2 | -1.4 | -1.0 | -1.3 | -1.1 | -0.9 |
| Bone: marrow area | 0.5 | 1.1 | 2.1 | -0.8 | -0.2 | -0.3 | -1.5 | 0.6 | 1.3 | -1.4 | -1.0 | -1.4 | -1.2 | -0.9 |
| Bone: minimum diameter | 0.5 | 0.9 | 1.3 | -0.7 | 0.1 | -0.4 | -1.2 | 0.6 | 1.1 | -1.1 | -1.1 | -1.1 | -1.0 | -1.0 |
| Time in closed arm after self-admin | 0.5 | 0.5 | 0.8 | -0.8 | 0.8 | -0.7 | -0.9 | 0.6 | 0.8 | -0.5 | -0.5 | -0.9 | -0.6 | -0.6 |
| Delay disc. indifference point, 8s delay | 0.5 | 0.6 | 0.7 | 0.9 | -0.7 | 0.8 | 0.8 | -0.6 | -0.8 | 0.5 | 0.7 | 0.8 | 0.8 | 0.7 |
| Change in fecal boli incidents, locomotor task | 0.5 | 0.5 | 1.3 | -0.2 | -0.4 | -0.1 | -0.4 | 0.8 | 0.4 | -1.2 | -0.9 | -0.4 | -0.9 | -0.9 |
| Bouts of movement, locomotor time 2 | 0.5 | 0.5 | 1.2 | -0.8 | 1.1 | -1.0 | -0.5 | 0.8 | 0.5 | -0.3 | -0.7 | -0.6 | -0.6 | -0.8 |
| Run reversals in cocaine runway, males | 0.5 | 0.5 | 1.6 | -0.3 | -0.5 | -0.1 | -0.7 | 0.7 | 0.7 | -1.3 | -0.7 | -0.7 | -0.6 | -0.9 |
| Co content in liver | 0.5 | 0.6 | 1.0 | -0.9 | 1.0 | -0.9 | -0.9 | 0.8 | 0.5 | -0.4 | -0.8 | -0.9 | -0.5 | -0.5 |
| Number of licking bursts | 0.4 | 0.5 | 1.1 | 0.8 | -0.6 | 0.7 | 0.7 | -0.4 | -1.0 | 0.6 | 0.8 | 0.7 | 0.8 | 0.7 |
| Indifference point 0 sec | 0.4 | 0.7 | 1.8 | 0.4 | 0.4 | 0.1 | 0.7 | -0.5 | -1.1 | 1.4 | 0.7 | 0.7 | 1.1 | 0.8 |
| Delay discounting water rate 12 sec | 0.4 | 0.6 | 0.8 | 0.7 | -0.5 | 0.6 | 0.8 | -0.7 | -0.9 | 0.9 | 0.9 | 0.8 | 0.8 | 0.7 |
| Reaction time omissions | 0.4 | 0.5 | 0.9 | 0.7 | -0.9 | 0.9 | 0.6 | -0.7 | -0.4 | 0.3 | 0.7 | 0.7 | 0.9 | 0.5 |
| Condit. Reinf. active-inactive response ratio | 0.4 | 0.4 | 1.6 | -0.6 | 1.3 | -1.0 | -0.1 | 0.9 | -0.4 | 0.3 | -0.1 | -0.1 | -0.4 | -0.5 |
| Conditioned reinforcement - actives | 0.4 | 0.4 | 1.0 | -0.5 | 0.1 | -0.3 | -0.6 | 0.9 | 0.4 | -1.0 | -0.8 | -0.8 | -0.1 | -0.8 |
| Intermittent access intake day 1-15 change | 0.4 | 0.4 | 0.9 | 0.5 | -0.3 | 0.4 | 0.7 | -0.4 | -0.7 | 0.6 | 0.5 | 0.9 | 0.9 | 0.5 |
| Intermittent access total infusions | 0.4 | 0.4 | 0.7 | -0.7 | 0.7 | -0.7 | -0.5 | 0.8 | 0.4 | -0.5 | -0.8 | -0.7 | -0.4 | -0.8 |
| Short access day 10 total inactive lever presses | 0.4 | 0.4 | 0.6 | -0.8 | 0.6 | -0.7 | -0.8 | 0.7 | 0.5 | -0.5 | -0.8 | -0.6 | -0.3 | -0.8 |
| Short access day 1 locomotion | 0.4 | 0.5 | 1.3 | -0.8 | 1.1 | -0.9 | -0.6 | 0.7 | 0.4 | -0.1 | -0.6 | -0.7 | -0.3 | -0.6 |
| Time in novel zone, hab. session 1 | 0.4 | 0.4 | 0.8 | -0.7 | 0.5 | -0.5 | -0.9 | 0.2 | 0.9 | -0.3 | -0.3 | -0.8 | -0.6 | -0.4 |
| Bone: cortical porosity | 0.4 | 0.5 | 1.0 | -0.7 | 0.4 | -0.5 | -0.9 | 0.3 | 1.0 | -0.6 | -0.6 | -0.9 | -0.6 | -0.5 |
| Bone: post-yield work | 0.4 | 0.6 | 1.5 | -0.9 | 1.2 | -1.0 | -0.7 | 1.0 | 0.1 | -0.2 | -0.7 | -0.8 | -0.3 | -0.6 |
| Distance traveled after self-admin | 0.4 | 0.4 | 1.8 | -0.6 | 1.3 | -0.9 | -0.4 | 0.7 | -0.5 | 0.4 | -0.2 | -0.4 | 0.2 | -0.2 |
| Ambulatory time after self-admin | 0.4 | 0.5 | 1.8 | 0.4 | 0.3 | 0.1 | 0.5 | -0.1 | -1.3 | 0.9 | 0.6 | 0.5 | 1.1 | 0.6 |
| Fecal boli incidents, locomotor time 1 | 0.4 | 0.4 | 0.7 | 0.6 | -0.3 | 0.5 | 0.6 | -0.4 | -0.8 | 0.6 | 0.8 | 0.7 | 0.6 | 0.8 |
| Total resting periods, locomotor time 2 | 0.4 | 0.5 | 1.2 | -0.8 | 1.1 | -1.0 | -0.4 | 0.8 | 0.3 | -0.2 | -0.5 | -0.4 | -0.6 | -0.6 |
| Glucose | 0.3 | 0.5 | 1.2 | 0.5 | 0.0 | 0.4 | 0.7 | -0.8 | -0.6 | 1.1 | 0.8 | 0.7 | 0.9 | 0.8 |
| Tail length | 0.3 | 0.8 | 1.3 | 0.9 | -1.1 | 1.1 | 0.8 | -1.1 | -0.5 | 0.5 | 1.0 | 0.9 | 0.8 | 0.8 |
| Intraocular pressure | 0.3 | 0.4 | 1.1 | -0.4 | -0.2 | -0.2 | -0.6 | 0.6 | 0.8 | -1.0 | -0.8 | -0.6 | -0.6 | -0.9 |
| Delay discounting total patch changes 24 sec | 0.3 | 0.4 | 1.0 | 0.5 | -0.3 | 0.4 | 0.6 | -0.4 | -0.7 | 0.6 | 0.5 | 0.6 | 1.0 | 0.6 |
| Delay discounting total patch changes 6 sec | 0.3 | 0.5 | 1.7 | 0.2 | 0.6 | -0.1 | 0.5 | 0.0 | -1.3 | 1.0 | 0.6 | 0.3 | 1.0 | 0.7 |
| Reaction time num false alarms AUC | 0.3 | 0.4 | 1.2 | 0.5 | -1.1 | 0.9 | 0.1 | -0.8 | 0.0 | -0.1 | 0.2 | 0.1 | 0.9 | 0.4 |
| Median of all reaction times | 0.3 | 0.3 | 0.7 | 0.5 | -0.2 | 0.4 | 0.7 | -0.7 | -0.5 | 0.8 | 0.7 | 0.5 | 0.5 | 0.6 |
| Reaction time premature initiation rate | 0.3 | 0.4 | 1.3 | 0.1 | 0.8 | -0.3 | 0.4 | -0.1 | -1.0 | 1.1 | 0.6 | 0.4 | 0.6 | 0.6 |
| Std. dev. reaction times | 0.3 | 0.4 | 0.8 | -0.6 | 0.2 | -0.4 | -0.8 | 0.3 | 0.9 | -0.6 | -0.5 | -0.9 | -0.5 | -0.7 |
| Condit. Reinf. lever presses | 0.3 | 0.4 | 1.0 | 0.3 | 0.3 | 0.0 | 0.6 | -0.2 | -1.0 | 0.9 | 0.7 | 0.6 | 0.7 | 0.7 |
| Condit. Reinf. lever reinforcers received | 0.3 | 0.4 | 0.9 | -0.6 | 0.9 | -0.8 | -0.5 | 0.9 | -0.1 | -0.3 | -0.3 | -0.5 | -0.3 | -0.6 |
| Post-drug Anxiety | 0.3 | 0.4 | 1.1 | -0.6 | 1.0 | -0.9 | -0.3 | 0.6 | 0.2 | 0.0 | -0.5 | -0.3 | -0.8 | -0.5 |
| Progressive ratio test 2 breakpoint | 0.3 | 0.3 | 0.9 | -0.5 | 1.0 | -0.8 | -0.2 | 0.9 | -0.2 | -0.0 | -0.4 | -0.5 | -0.0 | -0.4 |
| Progressive ratio test 2 inactive lever presses | 0.3 | 0.4 | 1.2 | -0.1 | 0.9 | -0.5 | 0.4 | 0.2 | -0.8 | 0.9 | 0.2 | 0.3 | 1.1 | 0.2 |
| Incentive salience index mean | 0.3 | 0.4 | 0.8 | 0.3 | 0.3 | 0.1 | 0.6 | -0.2 | -0.9 | 0.9 | 0.6 | 0.4 | 0.8 | 0.7 |
| Time in familiar zone, hab. session 2 | 0.3 | 0.3 | 1.4 | 0.4 | -1.2 | 0.8 | -0.1 | -0.5 | 0.5 | -0.6 | -0.2 | 0.1 | -0.0 | -0.1 |
| Time in novel zone, hab. session 2 | 0.3 | 0.3 | 1.2 | -0.6 | 1.1 | -0.8 | -0.2 | 0.6 | -0.4 | 0.4 | 0.0 | -0.2 | -0.0 | 0.0 |
| Pavlov. Cond. magazine entry number | 0.3 | 0.3 | 0.7 | -0.4 | -0.2 | -0.2 | -0.7 | 0.2 | 0.8 | -0.8 | -0.6 | -0.5 | -0.6 | -0.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 0.8 | 0.4 | 0.3 | 0.1 | 0.7 | -0.2 | -0.9 | 0.9 | 0.7 | 0.4 | 0.7 | 0.8 |
| Bone: apparent density | 0.3 | 0.5 | 0.8 | 0.6 | -0.2 | 0.5 | 0.8 | -0.6 | -0.7 | 0.9 | 0.9 | 0.8 | 0.6 | 0.7 |
| Bouts of movement, locomotor time 1 | 0.3 | 0.4 | 1.4 | -0.3 | 0.0 | -0.4 | -0.3 | 0.5 | 0.7 | -0.8 | -0.6 | -0.4 | -1.2 | -0.5 |
| Distance moved, locomotor task time 1 | 0.3 | 0.4 | 0.9 | -0.6 | -0.0 | -0.3 | -0.8 | 0.3 | 0.9 | -0.8 | -0.5 | -0.7 | -0.4 | -0.6 |
| Vertical activity count, locomotor time 2 | 0.3 | 0.3 | 0.6 | -0.6 | 0.2 | -0.4 | -0.7 | 0.4 | 0.8 | -0.6 | -0.5 | -0.4 | -0.2 | -0.6 |
| Latency to leave start box in cocaine runway, F | 0.3 | 0.3 | 0.5 | 0.6 | -0.6 | 0.6 | 0.5 | -0.7 | -0.3 | 0.5 | 0.6 | 0.6 | 0.4 | 0.7 |
| Length with tail | 0.2 | 0.8 | 2.0 | -0.7 | 0.2 | -0.6 | -0.9 | 0.9 | 0.9 | -1.2 | -0.9 | -0.8 | -1.4 | -1.0 |
| Parametrial fat weight | 0.2 | 0.3 | 0.5 | -0.6 | 0.6 | -0.7 | -0.5 | 0.6 | 0.6 | -0.4 | -0.5 | -0.7 | -0.5 | -0.5 |
| Extensor digitorum longus weight | 0.2 | 0.8 | 1.2 | 0.7 | -0.5 | 0.8 | 0.7 | -1.1 | -0.7 | 1.0 | 1.1 | 1.0 | 1.1 | 1.1 |
| Delay discounting total patch changes 18 sec | 0.2 | 0.3 | 0.8 | -0.0 | 0.7 | -0.3 | 0.3 | 0.1 | -0.8 | 0.7 | 0.3 | 0.4 | 0.9 | 0.2 |
| Delay discounting water rate 0 sec | 0.2 | 0.3 | 0.8 | 0.1 | 0.5 | -0.2 | 0.4 | 0.0 | -0.9 | 0.8 | 0.5 | 0.3 | 0.5 | 0.5 |
| Reaction time num false alarms | 0.2 | 0.2 | 0.9 | 0.4 | -0.9 | 0.8 | -0.1 | -0.7 | 0.2 | -0.2 | -0.0 | -0.0 | 0.7 | 0.3 |
| Social response proportion | 0.2 | 0.3 | 1.3 | -0.7 | 1.2 | -0.8 | -0.3 | 0.2 | 0.3 | 0.4 | -0.1 | -0.2 | -0.3 | -0.1 |
| Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.8 | -0.4 | 0.9 | -0.7 | 0.0 | 0.8 | -0.6 | 0.2 | 0.0 | -0.0 | 0.0 | -0.3 |
| Conditioned reinforcement - inactives | 0.2 | 0.2 | 0.7 | -0.3 | 0.8 | -0.4 | 0.1 | 0.3 | -0.6 | 0.5 | -0.0 | -0.2 | 0.6 | -0.0 |
| Intermittent access intake escalation 2 | 0.2 | 0.2 | 0.6 | 0.4 | -0.3 | 0.4 | 0.4 | -0.5 | -0.4 | 0.4 | 0.4 | 0.7 | 0.7 | 0.4 |
| Intermittent access day 15 total locomotion | 0.2 | 0.2 | 0.3 | -0.4 | 0.4 | -0.4 | -0.2 | 0.5 | 0.3 | -0.3 | -0.5 | -0.3 | -0.4 | -0.5 |
| Incentive Sensitization - Responses | 0.2 | 0.2 | 0.5 | 0.1 | 0.4 | -0.2 | 0.3 | 0.1 | -0.7 | 0.6 | 0.3 | 0.1 | 0.6 | 0.3 |
| One hour access (0.3 mA shock) | 0.2 | 0.3 | 1.2 | 0.5 | -0.4 | 0.5 | 0.6 | -0.4 | -0.4 | 0.4 | 0.3 | 0.4 | 1.1 | 0.3 |
| One hour access (shock baseline) | 0.2 | 0.2 | 0.6 | -0.4 | 0.2 | -0.3 | -0.3 | 0.2 | 0.8 | -0.4 | -0.6 | -0.5 | -0.3 | -0.6 |
| Locomotion velocity, session 2 | 0.2 | 0.2 | 0.5 | -0.4 | 0.2 | -0.2 | -0.6 | 0.4 | 0.4 | -0.5 | -0.4 | -0.7 | -0.4 | -0.3 |
| Locomotion velocity, session 3 | 0.2 | 0.2 | 0.7 | 0.0 | -0.7 | 0.3 | -0.5 | 0.1 | 0.5 | -0.9 | -0.3 | -0.6 | -0.5 | -0.3 |
| Locomotion velocity, session 7 | 0.2 | 0.2 | 0.6 | -0.1 | -0.4 | 0.1 | -0.4 | 0.2 | 0.6 | -0.8 | -0.6 | -0.4 | -0.6 | -0.4 |
| Condit. Reinf. active-inactive response ratio | 0.2 | 0.3 | 0.4 | -0.5 | 0.3 | -0.5 | -0.6 | 0.5 | 0.4 | -0.5 | -0.6 | -0.7 | -0.5 | -0.5 |
| Pavlov. Cond. index score | 0.2 | 0.3 | 0.7 | 0.2 | 0.6 | -0.2 | 0.5 | -0.0 | -0.8 | 0.8 | 0.5 | 0.2 | 0.6 | 0.7 |
| Pavlov. Cond. latency score | 0.2 | 0.3 | 0.7 | 0.1 | 0.6 | -0.1 | 0.5 | -0.1 | -0.7 | 0.8 | 0.5 | 0.2 | 0.7 | 0.7 |
| Bone surface | 0.2 | 0.3 | 0.7 | 0.7 | -0.6 | 0.6 | 0.5 | -0.4 | -0.9 | 0.4 | 0.6 | 0.6 | 0.4 | 0.6 |
| Bone: trabecular thickness | 0.2 | 0.2 | 0.5 | 0.4 | -0.3 | 0.4 | 0.4 | -0.7 | -0.2 | 0.6 | 0.5 | 0.4 | 0.6 | 0.5 |
| Distance traveled before self-admin | 0.2 | 0.2 | 1.0 | -0.5 | 1.0 | -0.7 | -0.2 | 0.4 | 0.1 | 0.3 | -0.2 | -0.3 | 0.1 | -0.2 |
| Diff in mean of infusions in LGA sessions | 0.2 | 0.2 | 0.6 | 0.5 | -0.1 | 0.2 | 0.7 | -0.1 | -0.8 | 0.5 | 0.5 | 0.6 | 0.1 | 0.5 |
| Delta distance traveled before/after self-admin | 0.2 | 0.2 | 0.5 | -0.4 | 0.2 | -0.3 | -0.6 | 0.7 | -0.0 | -0.6 | -0.4 | -0.5 | -0.3 | -0.4 |
| Delta ambulatory time before/after self-admin | 0.2 | 0.3 | 0.8 | -0.5 | 0.4 | -0.4 | -0.6 | 0.9 | -0.2 | -0.6 | -0.5 | -0.5 | -0.3 | -0.4 |
| Time in open arm before self-admin | 0.2 | 0.2 | 0.7 | 0.2 | -0.8 | 0.4 | -0.1 | -0.0 | 0.5 | -0.8 | -0.2 | -0.1 | -0.2 | -0.2 |
| Time to tail flick, test, before self-admin | 0.2 | 0.2 | 0.9 | 0.2 | -0.9 | 0.5 | -0.2 | -0.2 | 0.5 | -0.8 | -0.0 | -0.2 | -0.1 | -0.1 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.3 | -0.4 | 0.4 | -0.4 | -0.5 | 0.6 | 0.4 | -0.5 | -0.5 | -0.6 | -0.3 | -0.5 |
| Delay disc. indifference point, 24s delay | 0.2 | 0.2 | 0.8 | 0.7 | -0.9 | 0.6 | 0.4 | 0.2 | -0.6 | -0.3 | 0.2 | 0.3 | -0.2 | 0.1 |
| Delay disc. indifference point, 4s delay | 0.2 | 0.2 | 0.9 | -0.5 | 1.0 | -0.7 | -0.1 | 0.6 | -0.4 | 0.3 | -0.2 | -0.2 | 0.3 | -0.2 |
| Total resting periods, locomotor time 1 | 0.2 | 0.2 | 0.9 | -0.2 | 0.3 | -0.4 | -0.1 | 0.4 | 0.4 | -0.3 | -0.4 | -0.3 | -1.0 | -0.3 |
| Latency to leave start box in cocaine runway | 0.2 | 0.2 | 0.6 | -0.4 | 0.2 | -0.4 | -0.4 | 0.2 | 0.8 | -0.5 | -0.5 | -0.5 | -0.7 | -0.4 |
| Mn content in liver | 0.2 | 0.2 | 0.6 | -0.2 | -0.3 | 0.0 | -0.5 | 0.3 | 0.4 | -0.8 | -0.5 | -0.6 | -0.2 | -0.4 |
| Soleus weight | 0.1 | 0.3 | 1.2 | 0.3 | 0.3 | 0.0 | 0.4 | 0.1 | -1.1 | 0.6 | 0.5 | 0.5 | 0.8 | 0.6 |
| Indifference point AUC | 0.1 | 0.2 | 0.6 | 0.4 | -0.4 | 0.3 | 0.4 | 0.1 | -0.8 | 0.0 | 0.4 | 0.4 | 0.4 | 0.3 |
| Delay discounting total patch changes 12 sec | 0.1 | 0.1 | 0.3 | -0.2 | 0.6 | -0.4 | 0.0 | 0.3 | -0.4 | 0.3 | -0.0 | -0.1 | 0.4 | 0.1 |
| Delay discounting time to switch 0 sec | 0.1 | 0.1 | 0.4 | 0.2 | -0.3 | 0.3 | 0.1 | -0.6 | 0.3 | 0.2 | 0.1 | 0.2 | 0.1 | 0.2 |
| Delay discounting water rate 24 sec | 0.1 | 0.1 | 0.5 | -0.3 | 0.7 | -0.5 | 0.0 | 0.3 | -0.3 | 0.4 | -0.0 | 0.0 | -0.0 | -0.2 |
| Reaction time mean minus median | 0.1 | 0.1 | 0.4 | -0.3 | -0.1 | -0.0 | -0.6 | -0.0 | 0.6 | -0.4 | -0.2 | -0.6 | -0.3 | -0.3 |
| Reaction time mean | 0.1 | 0.1 | 0.3 | 0.3 | -0.1 | 0.3 | 0.4 | -0.5 | -0.2 | 0.5 | 0.5 | 0.2 | 0.3 | 0.3 |
| Reaction time mean AUC | 0.1 | 0.1 | 0.2 | 0.3 | -0.2 | 0.3 | 0.3 | -0.5 | -0.2 | 0.4 | 0.5 | 0.2 | 0.3 | 0.3 |
| Reaction time false alarm rate | 0.1 | 0.2 | 0.5 | -0.4 | 0.1 | -0.1 | -0.7 | 0.0 | 0.6 | -0.3 | -0.5 | -0.6 | 0.4 | -0.2 |
| Social responses | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | 0.4 | 0.1 | -0.3 | -0.3 | 0.1 | 0.4 | 0.2 | 0.2 | 0.4 |
| Cocaine response before conditioning | 0.1 | 0.2 | 0.5 | 0.2 | -0.1 | 0.3 | 0.1 | -0.5 | -0.2 | 0.4 | 0.6 | -0.0 | 0.7 | 0.5 |
| Saline control response | 0.1 | 0.2 | 0.6 | 0.1 | -0.8 | 0.6 | -0.4 | -0.5 | 0.4 | -0.4 | 0.3 | -0.3 | 0.4 | 0.2 |
| Intermitt. access escalation Index | 0.1 | 0.1 | 0.5 | -0.2 | 0.7 | -0.4 | 0.1 | 0.3 | -0.4 | 0.4 | -0.1 | 0.2 | 0.0 | -0.1 |
| Intermittent access day 15 total infusions | 0.1 | 0.1 | 0.3 | -0.3 | 0.6 | -0.4 | 0.0 | 0.4 | -0.3 | 0.1 | -0.3 | -0.0 | 0.5 | -0.3 |
| Intermittent access terminal intake (last 3 days) | 0.1 | 0.1 | 0.2 | -0.2 | 0.1 | -0.2 | -0.2 | 0.4 | 0.2 | -0.4 | -0.5 | -0.3 | 0.2 | -0.5 |
| Incentive Sensitization - Breakpoint | 0.1 | 0.1 | 0.4 | -0.1 | 0.6 | -0.4 | 0.1 | 0.4 | -0.6 | 0.4 | 0.1 | -0.1 | 0.4 | 0.1 |
| Progressive ratio test 2 active lever presses | 0.1 | 0.1 | 0.4 | -0.3 | 0.6 | -0.5 | 0.0 | 0.6 | -0.3 | 0.0 | -0.3 | -0.2 | 0.2 | -0.3 |
| Short access day 10 total locomotion | 0.1 | 0.1 | 0.3 | -0.4 | 0.5 | -0.3 | -0.3 | -0.1 | 0.3 | 0.3 | -0.2 | -0.5 | 0.4 | -0.2 |
| Locomotion velocity, session 1 | 0.1 | 0.1 | 0.6 | 0.4 | -0.8 | 0.5 | 0.1 | 0.1 | -0.4 | -0.4 | 0.1 | 0.1 | 0.0 | 0.0 |
| Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.4 | 0.1 | 0.3 | -0.1 | 0.3 | 0.0 | -0.6 | 0.5 | 0.2 | 0.1 | 0.4 | 0.4 |
| Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.3 | 0.0 | -0.3 | 0.1 | -0.1 | 0.4 | 0.0 | -0.6 | -0.5 | -0.0 | -0.2 | -0.4 |
| Bone: connectivity density | 0.1 | 0.2 | 0.4 | 0.4 | -0.0 | 0.2 | 0.5 | -0.3 | -0.5 | 0.6 | 0.6 | 0.6 | 0.2 | 0.4 |
| Bone: tissue strength | 0.1 | 0.1 | 0.2 | -0.3 | 0.4 | -0.4 | -0.3 | 0.4 | 0.1 | -0.1 | -0.4 | -0.2 | -0.4 | -0.4 |
| Bone: trabecular number | 0.1 | 0.1 | 0.4 | 0.3 | -0.6 | 0.4 | 0.1 | -0.2 | 0.3 | -0.3 | 0.1 | 0.2 | -0.2 | -0.1 |
| Breakpoint value in progressive ratio session | 0.1 | 0.1 | 0.4 | -0.1 | 0.5 | -0.2 | 0.1 | -0.1 | -0.3 | 0.6 | 0.2 | 0.1 | 0.5 | 0.1 |
| Active lever presses in extinction session 6 | 0.1 | 0.1 | 0.4 | -0.5 | 0.6 | -0.5 | -0.5 | 0.3 | 0.3 | -0.1 | -0.2 | -0.4 | 0.0 | -0.2 |
| Delta time to tail flick, vehicle, before/after SA | 0.1 | 0.1 | 0.3 | 0.3 | -0.2 | 0.3 | 0.4 | -0.5 | -0.2 | 0.5 | 0.3 | 0.5 | 0.4 | 0.3 |
| Ambulatory time before self-admin | 0.1 | 0.1 | 0.5 | -0.4 | 0.7 | -0.5 | -0.1 | 0.2 | -0.1 | 0.3 | -0.1 | -0.2 | 0.5 | -0.2 |
| Total heroin consumption | 0.1 | 0.1 | 0.4 | -0.3 | 0.6 | -0.5 | -0.2 | 0.5 | -0.2 | 0.0 | 0.0 | -0.1 | 0.1 | -0.1 |
| Area under the delay curve | 0.1 | 0.1 | 0.2 | 0.3 | -0.2 | 0.3 | 0.3 | -0.0 | -0.5 | 0.1 | 0.3 | 0.3 | 0.3 | 0.2 |
| Delay discount exponential model param | 0.1 | 0.1 | 0.3 | -0.4 | 0.3 | -0.3 | -0.4 | 0.1 | 0.6 | -0.2 | -0.3 | -0.4 | -0.4 | -0.3 |
| Time >=10cm from walls, locomotor time 1 | 0.1 | 0.1 | 0.2 | -0.2 | 0.3 | -0.3 | -0.3 | 0.3 | 0.2 | -0.2 | -0.2 | -0.3 | -0.4 | -0.2 |
| Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.2 | 0.4 | -0.1 | 0.3 | 0.2 | -0.2 | -0.5 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| Rest time, locomotor task time 2 | 0.1 | 0.1 | 0.3 | 0.2 | 0.0 | 0.1 | 0.3 | 0.0 | -0.5 | 0.3 | 0.2 | 0.1 | 0.0 | 0.2 |
| Weight adjusted by age | 0.1 | 0.1 | 0.4 | 0.3 | -0.7 | 0.5 | 0.1 | -0.1 | -0.2 | -0.3 | 0.1 | 0.0 | 0.0 | 0.2 |
| Progressive ratio | 0.1 | 0.2 | 0.4 | 0.1 | 0.2 | 0.0 | 0.4 | -0.3 | -0.4 | 0.7 | 0.5 | 0.4 | 0.5 | 0.5 |
| BMI without tail | 0.0 | 0.0 | 0.1 | -0.3 | 0.3 | -0.1 | -0.2 | -0.2 | 0.4 | 0.1 | -0.1 | -0.2 | 0.2 | -0.2 |
| Locomotor testing distance | 0.0 | 0.0 | 0.0 | 0.2 | -0.2 | 0.2 | 0.2 | -0.1 | -0.1 | 0.1 | 0.2 | 0.0 | -0.2 | 0.1 |
| Light reinforcement 1 | 0.0 | 0.1 | 0.2 | -0.0 | -0.4 | 0.3 | -0.4 | -0.1 | 0.1 | -0.4 | -0.3 | -0.3 | 0.4 | -0.1 |
| Cocaine response after cond. corrected | 0.0 | 0.0 | 0.1 | 0.0 | -0.2 | 0.1 | -0.2 | 0.0 | 0.2 | -0.3 | -0.3 | -0.2 | -0.3 | -0.1 |
| Cocaine response after cond. not corrected | 0.0 | 0.0 | 0.1 | 0.1 | -0.3 | 0.2 | -0.2 | -0.2 | 0.2 | -0.1 | -0.1 | -0.3 | -0.0 | 0.1 |
| Locomotion distance, session 7 | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | -0.0 | 0.3 | 0.1 | 0.0 | -0.1 | -0.1 | 0.2 | -0.2 | 0.0 |
| Bone volume | 0.0 | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | 0.2 | -0.2 | -0.3 | 0.2 | 0.3 | 0.2 | 0.1 | 0.3 |
| Bone: elastic displacement | 0.0 | 0.0 | 0.3 | 0.2 | -0.5 | 0.3 | -0.1 | -0.1 | -0.0 | -0.3 | 0.1 | -0.0 | -0.1 | -0.0 |
| Extinction: sum of active levers before priming | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | -0.2 | -0.0 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.2 | 0.0 |
| Sum of active levers in priming session hrs 5-6 | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 | 0.2 | -0.3 | -0.1 | 0.3 | 0.3 | 0.2 | 0.2 | 0.2 |
| Time to tail flick, vehicle, before self-admin | 0.0 | 0.0 | 0.1 | 0.1 | -0.4 | 0.2 | -0.0 | -0.0 | -0.1 | -0.2 | 0.2 | -0.0 | -0.3 | 0.2 |
| Delay discount hyperbolic model param | 0.0 | 0.0 | 0.1 | -0.2 | 0.1 | -0.1 | -0.1 | -0.1 | 0.4 | -0.0 | -0.1 | -0.1 | -0.3 | -0.1 |
| Vertical activity count, locomotor time 1 | 0.0 | 0.0 | 0.1 | -0.0 | -0.0 | 0.0 | 0.1 | -0.2 | 0.0 | 0.1 | 0.2 | 0.2 | 0.3 | 0.0 |
| Fe content in liver | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 | -0.3 | 0.2 | 0.1 | 0.2 | -0.3 | 0.1 | 0.2 |
| Rb content in liver | 0.0 | 0.0 | 0.2 | -0.1 | 0.4 | -0.3 | 0.0 | 0.2 | -0.3 | 0.2 | -0.0 | -0.2 | 0.1 | 0.0 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.