Hub : Genes

Ugt2b10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression ENSRNOG00000062781 0.05 0.03 7.9e-05 0.03 0.02 0.03 0.03 4.4e-04 2.1e-03 3.1e-04 3.2e-04
2 Liver mRNA stability ENSRNOG00000062781 0.11 0.07 2.9e-08 0.02 0.06 0.02 0.03 2.3e-03 9.3e-08 5.6e-03 1.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail1.75.56.4-2.22.5
BMI without tail1.02.14.2-0.22.0
Body weight0.52.13.6-0.81.9
Epididymis fat weight0.51.22.4-0.01.6
Glucose1.32.03.71.9-0.5
Heart weight0.30.50.9-1.00.2
Left kidney weight0.20.50.80.5-0.9
Right kidney weight0.20.60.80.90.6
Tail length0.10.20.20.4-0.4
Length with tail0.31.22.01.4-0.6
Length without tail0.10.30.60.8-0.0
Liver weight, left1.93.15.32.30.9
Liver weight, right2.03.36.42.50.3
Parametrial fat weight1.32.64.42.10.9
Retroperitoneal fat weight1.24.06.31.32.5
Intraocular pressure0.60.90.9-1.00.9
Extensor digitorum longus weight5.823.445.4-6.71.2
Soleus weight0.72.03.3-0.8-1.8
Tibialis anterior weight2.89.716.5-4.11.7
Tibia length0.10.30.30.50.5
Number of licking bursts0.20.20.4-0.6-0.0
Food consumed during 24 hour testing period2.42.93.51.5-1.9
Times rat made contact with spout0.30.40.40.60.5
Mean time between licks in bursts3.44.77.5-2.71.4
Mean num. licks in bursts0.81.01.71.30.5
Std. dev. time between licks in bursts1.11.42.6-1.6-0.4
Water consumed over 24 hours1.11.32.21.5-0.7
Indifference point 0 sec0.20.30.70.8-0.1
Indifference point AUC2.32.84.92.20.8
Indifference point function ln k0.91.22.0-1.4-0.7
Indifference point function log k0.91.22.0-1.4-0.7
Delay discounting total patch changes 0 sec0.20.30.70.80.0
Delay discounting total patch changes 12 sec0.91.11.40.91.2
Delay discounting total patch changes 18 sec0.30.40.40.60.6
Delay discounting total patch changes 24 sec0.50.61.31.1-0.1
Delay discounting total patch changes 6 sec1.21.83.41.80.5
Delay discounting time to switch 0 sec2.74.17.1-2.71.0
Delay discounting water rate 0 sec1.32.14.12.0-0.4
Delay discounting water rate 12 sec0.81.11.80.7-1.4
Delay discounting water rate 18 sec2.02.73.01.7-1.5
Delay discounting water rate 24 sec2.53.55.01.4-2.2
Delay discounting water rate 6 sec0.50.81.51.2-0.3
Locomotor activity0.81.32.40.4-1.6
Locomotor testing distance1.82.95.8-0.2-2.4
Locomotor testing rearing1.42.14.1-0.4-2.0
Light reinforcement 10.20.30.60.80.0
Light reinforcement 20.10.10.2-0.40.3
Reaction time number correct0.10.10.2-0.2-0.4
Reaction time mean minus median0.91.11.8-0.71.3
Reaction time mean minus median AUC1.92.44.7-0.42.2
Reaction time num false alarms0.81.22.20.41.5
Reaction time num false alarms AUC0.91.32.60.11.6
Reaction time trials correct on left0.10.10.2-0.2-0.4
Reaction time trials on left0.10.20.2-0.3-0.5
Reaction time mean0.81.11.5-0.91.2
Reaction time mean AUC0.91.21.8-0.81.3
Median of all reaction times0.70.91.2-0.81.1
Reaction time omissions0.81.01.6-1.30.7
Reaction time false alarm rate0.91.32.70.11.6
Reaction time premature initiation rate0.10.20.20.40.4
Reaction time premature initiations0.10.20.20.40.4
Std. dev. reaction times0.70.91.4-0.71.2
Reaction time trials completed0.10.20.2-0.3-0.5
Reaction time trials AUC0.10.10.1-0.4-0.2
Social response proportion2.02.23.71.90.8
Social responses0.81.01.81.30.5
Social time0.71.01.81.30.4
Conditioned locomotion0.30.40.6-0.7-0.4
Cocaine response after cond. corrected0.40.50.90.9-0.3
Cocaine response after cond. not corrected0.60.60.70.8-0.8
Cocaine response before conditioning0.40.50.5-0.7-0.7
Saline control response0.30.30.40.7-0.5
Condit. Reinf. active minus inactive responses0.00.00.10.30.2
Condit. Reinf. active-inactive response ratio0.10.20.20.50.3
Condit. Reinf. active responses0.10.10.10.2-0.4
Condit. Reinf. inactive responses0.50.61.20.3-1.1
Condit. Reinf. lever presses0.91.22.10.5-1.4
Condit. Reinf. lever reinforcers received0.30.40.70.2-0.8
Pavlov. Cond. lever latency0.81.11.90.61.4
Pavlov. Cond. magazine entry latency1.11.31.6-1.3-1.0
Pavlov. Cond. change in total contacts1.31.72.4-1.1-1.5
Pavlov. Cond. index score1.82.33.0-1.3-1.7
Pavlov. Cond. latency score2.22.83.3-1.5-1.8
Pavlov. Cond. lever contacts1.21.63.0-0.5-1.7
Pavlov. Cond. magazine entry number2.12.53.21.81.4
Pavlov. Cond. intertrial magazine entries1.41.82.51.61.0
Pavlov. Cond. lever-magazine prob. diff.1.72.22.9-1.2-1.7
Pavlov. Cond. response bias1.62.13.1-1.1-1.8
Conditioned reinforcement - actives0.50.50.5-0.7-0.7
Conditioned reinforcement - inactives1.11.32.01.4-0.7
Conditioned locomotion0.20.30.4-0.4-0.7
Intermittent access intake day 1-15 change1.71.61.8-1.3-1.2
Intermittent access intake escalation1.21.21.7-0.8-1.3
Intermittent access intake escalation 20.50.50.90.2-1.0
Intermitt. access day 1 inactive lever presses1.01.11.81.3-0.7
Intermitt. access day 15 inactive lever presses1.61.72.81.7-0.8
Intermitt. access escalation Index0.50.40.8-0.9-0.2
Intermittent access day 1 total infusions0.00.00.00.1-0.2
Intermittent access day 15 total infusions0.70.71.50.1-1.2
Intermittent access terminal intake (last 3 days)0.80.91.40.5-1.2
Intermittent access total infusions0.20.20.40.1-0.6
Intermittent access day 1 locomotion0.00.00.00.0-0.2
Intermittent access day 15 total locomotion0.20.20.3-0.3-0.6
Intermittent access total locomotion0.10.10.2-0.40.1
Intermittent access standard deviation0.50.50.90.3-0.9
Cocaine induced anxiety0.10.20.2-0.40.4
Post-drug Anxiety0.80.91.70.41.3
Baseline Anxiety0.50.50.50.7-0.7
Lifetime Intake0.10.10.2-0.1-0.4
Incentive Sensitization - Responses0.00.00.00.10.2
Incentive Sensitization - Breakpoint0.00.00.00.10.0
Progressive ratio test 1 active lever presses0.20.20.4-0.70.1
Progressive ratio test 1 breakpoint0.20.20.5-0.7-0.0
Progressive ratio test 1 inactive lever presses1.41.52.91.7-0.4
Progressive ratio test 2 active lever presses0.10.10.10.30.2
Progressive ratio test 2 breakpoint0.00.00.10.10.3
Progressive ratio test 2 inactive lever presses0.80.91.41.2-0.7
Total sessions with >9 infusions0.80.91.3-1.1-0.6
Short access day 1 total inactive lever presses2.22.43.21.3-1.8
Short access day 10 total inactive lever presses2.02.12.31.4-1.5
Short access day 1 total infusions0.00.00.00.0-0.0
Short access day 10 total infusions0.10.20.2-0.3-0.5
Short access total infusions0.10.10.3-0.5-0.0
Short access day 1 locomotion0.20.20.3-0.60.1
Short access day 10 total locomotion0.40.50.9-0.20.9
Short access total locomotion0.40.40.7-0.80.4
Compulsive drug intake0.60.60.60.80.8
One hour access (0.3 mA shock)0.40.40.40.6-0.7
One hour access (shock baseline)0.00.10.10.0-0.3
Number of responses in last shaping day0.50.50.9-1.00.4
Context. condit. distance diff. score2.63.26.5-0.0-2.5
Locomotion velocity, session 11.81.93.3-0.71.8
Locomotion distance, session 10.10.20.20.4-0.4
Locomotion velocity, session 20.10.10.3-0.0-0.5
Locomotion distance, session 20.00.00.10.3-0.2
Locomotion velocity, session 30.40.50.80.9-0.3
Locomotion distance, session 30.10.10.10.1-0.3
Stereotopy head waving bouts, day 30.70.80.9-0.81.0
Stereotopy head waving duration, day 30.10.20.3-0.20.5
Locomotion velocity, session 71.31.42.81.70.3
Locomotion distance, session 70.91.22.01.4-0.6
Stereotopy head waving bouts, day 70.10.10.2-0.5-0.1
Stereotopy head waving duration, day 70.60.71.2-0.51.1
Locomotion velocity, session 80.50.61.1-0.2-1.0
Locomotion distance, session 82.23.26.20.5-2.5
Degree of sensitization distance0.90.91.51.2-0.5
Degree of sensitization stereotypy0.00.10.1-0.1-0.3
Condit. Reinf. active minus inactive responses0.80.91.1-1.10.8
Condit. Reinf. active-inactive response ratio2.32.54.9-2.20.2
Condit. Reinf. active responses0.10.10.20.10.4
Condit. Reinf. inactive responses1.61.93.71.9-0.2
Incentive salience index mean0.20.20.3-0.40.5
Condit. Reinf. lever presses0.00.00.0-0.1-0.2
Time in familiar zone, hab. session 10.80.71.30.3-1.2
Time in novel zone, hab. session 12.52.44.4-0.72.1
Total zone transitions, hab. session 10.10.10.20.4-0.2
Total locomotion distance, hab. session 11.62.22.41.4-1.6
Locomotion velocity, hab. session 11.82.53.31.3-1.8
Time in familiar zone, hab. session 20.10.10.1-0.3-0.3
Time in novel zone, hab. session 21.31.32.7-0.11.6
Total zone transitions, hab. session 20.30.40.8-0.0-0.9
Total locomotion distance, hab. session 20.81.01.60.6-1.3
Locomotion velocity, hab. session 20.91.32.00.7-1.4
Novel to familiar place preference ratio1.31.42.70.31.6
Novelty place preference1.92.04.00.12.0
Time in novel zone, NPP test2.22.34.50.32.1
Total zone transitions, NPP test0.00.00.00.20.2
Total locomotion distance, NPP test0.60.81.60.3-1.3
Locomotion velocity, NPP test0.60.81.6-0.1-1.3
Pavlov. Cond. lever latency0.30.40.5-0.7-0.5
Pavlov. Cond. magazine entry latency0.30.30.70.1-0.8
Pavlov. Cond. change in total contacts0.10.10.2-0.10.4
Pavlov. Cond. index score0.10.10.10.30.3
Pavlov. Cond. latency score0.10.10.20.40.2
Pavlov. Cond. lever contacts0.30.40.60.70.4
Pavlov. Cond. magazine entry number0.10.10.10.3-0.1
Pavlov. Cond. intertrial magazine entries0.70.91.40.61.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.40.2
Pavlov. Cond. response bias0.10.10.20.50.1
Bone: apparent density0.20.30.6-0.8-0.1
Bone surface0.61.01.6-0.6-1.3
Bone volume0.10.20.40.1-0.6
Bone: connectivity density0.50.81.5-1.20.3
Bone: cortical apparent density2.83.76.80.72.6
Bone: cortical area0.10.20.20.50.4
Bone: cortical porosity1.51.72.9-1.7-0.6
Bone: cortical porosity2.12.24.5-2.1-0.0
Bone: cortical thickness0.40.71.0-1.00.6
Bone: cortical thickness0.60.71.40.1-1.2
Bone: cortical tissue density2.83.76.90.62.6
Bone: elastic displacement1.31.52.3-0.8-1.5
Bone: elastic work1.21.52.6-0.7-1.6
Bone: endosteal estimation1.22.63.82.0-1.2
Bone: endosteal perimeter0.40.90.90.9-0.9
Bone: final force0.00.10.10.20.3
Bone: final moment0.00.10.10.20.3
Bone: marrow area1.22.63.61.9-1.3
Bone: maximum diameter0.30.61.20.11.1
Bone: maximum force0.10.20.30.5-0.3
Bone: maximum moment0.10.20.40.6-0.3
Bone: minimum diameter2.54.79.03.0-0.6
Bone: periosteal estimation0.40.81.41.2-0.4
Bone: periosteal perimeter0.30.60.90.9-0.5
Bone: post-yield work0.10.20.20.30.5
Bone: stiffness0.91.51.61.11.3
Bone: tissue strength0.70.61.21.10.2
Bone: trabecular number0.20.40.4-0.50.7
Bone: trabecular spacing1.11.42.80.01.7
Bone: trabecular thickness0.40.50.90.4-1.0
Bone: trabecular tissue density0.81.11.7-0.61.3
Breakpoint value in progressive ratio session0.30.30.40.60.5
Distance traveled before self-admin0.20.20.30.5-0.3
Distance traveled after self-admin3.23.53.81.8-2.0
Delta time in closed arm before/after self-admin0.90.91.2-1.10.7
Delta time in open arm before/after self-admin0.60.61.11.10.2
Diff in mean of infusions in LGA sessions0.10.10.20.0-0.4
Extinction: sum of active levers before priming0.70.70.70.9-0.8
Active lever presses in extinction session 60.60.61.11.1-0.1
Delta distance traveled before/after self-admin0.70.81.00.8-1.0
Delta ambulatory time before/after self-admin0.40.40.70.3-0.8
Time in closed arm before self-admin0.40.40.80.9-0.4
Time in closed arm after self-admin0.30.30.5-0.4-0.7
Time in open arm before self-admin1.31.31.5-1.2-1.1
Time in open arm after self-admin0.91.01.51.20.7
Sum of active levers in priming session hrs 5-60.90.91.11.0-0.8
Time to tail flick, vehicle, before self-admin0.30.30.60.7-0.3
Time to tail flick, vehicle, after self-admin2.32.44.20.9-2.0
Time to tail flick, test, before self-admin0.10.10.1-0.2-0.4
Time to tail flick, test, after self-admin1.01.02.01.4-0.2
Delta time to tail flick, vehicle, before/after SA0.20.20.20.3-0.5
Delta time to tail flick, test, before/after SA1.21.11.61.30.7
Ambulatory time before self-admin0.20.20.40.6-0.1
Ambulatory time after self-admin2.72.93.41.8-1.6
Total heroin consumption1.61.93.01.7-0.9
Area under the delay curve0.30.30.70.00.8
Delay disc. indifference point, 0s delay0.40.40.8-0.30.9
Delay disc. indifference point, 16s delay1.61.62.8-0.61.7
Delay disc. indifference point, 2s delay1.92.14.22.1-0.0
Delay disc. indifference point, 24s delay0.10.10.1-0.40.0
Delay disc. indifference point, 4s delay1.11.21.50.91.2
Delay disc. indifference point, 8s delay1.41.41.7-1.31.1
Delay discount exponential model param0.30.30.5-0.3-0.7
Delay discount hyperbolic model param0.40.40.5-0.6-0.7
Fecal boli incidents, locomotor time 10.80.91.4-1.2-0.6
Change in fecal boli incidents, locomotor task0.00.00.0-0.0-0.1
Time >=10cm from walls, locomotor time 10.40.40.8-0.9-0.1
Bouts of movement, locomotor time 10.80.91.1-1.10.8
Total resting periods, locomotor time 10.60.60.7-0.80.8
Rest time, locomotor task time 11.51.62.80.7-1.7
Distance moved, locomotor task time 10.10.20.3-0.20.5
Vertical activity count, locomotor time 12.42.54.70.62.2
Time >=10cm from walls, locomotor time 20.70.71.2-0.4-1.1
Bouts of movement, locomotor time 20.10.10.20.4-0.0
Total resting periods, locomotor time 20.10.10.10.30.1
Rest time, locomotor task time 21.92.24.00.6-2.0
Distance moved, locomotor task time 21.31.51.9-1.41.0
Vertical activity count, locomotor time 21.41.53.1-0.11.7
Weight adjusted by age1.21.32.2-1.5-0.7
Seeking ratio, delayed vs. immediate footshock0.70.80.90.8-1.0
Locomotion in novel chamber0.10.20.20.30.5
Locomotion in novel chamber post-restriction1.01.21.61.20.9
Progressive ratio0.50.60.7-0.8-0.7
Food seeking constrained by brief footshock0.10.10.3-0.50.1
Seeking ratio, punishment vs. effort0.40.50.60.60.8
Run reversals in cocaine runway, females1.61.62.31.5-0.9
Run reversals in cocaine runway, males0.00.00.0-0.2-0.2
Latency to leave start box in cocaine runway2.42.65.22.30.1
Latency to leave start box in cocaine runway, F3.53.97.72.80.3
Latency to leave start box in cocaine runway, M0.10.10.1-0.3-0.4
Cd content in liver0.91.01.4-1.20.8
Co content in liver0.00.00.00.00.1
Cu content in liver0.20.20.30.60.3
Fe content in liver1.51.82.5-1.11.6
K content in liver1.61.62.30.91.5
Mg content in liver2.22.23.41.01.9
Mn content in liver0.10.10.2-0.40.1
Na content in liver1.61.72.01.21.4
Rb content in liver0.81.01.2-0.91.1
Se content in liver0.10.20.30.20.5
Sr content in liver1.00.91.5-0.6-1.2
Zn content in liver0.80.81.61.3-0.3