Hub : Genes

ENSRNOG00000062389

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000062389 0.02 0.02 5.7e-03 0.03 0.02 0.01 0.03 4.3e-04 5.8e-03 1.6e-02 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
BMI with tail2.16.96.9-2.6
BMI without tail0.00.10.1-0.2
Body weight0.72.92.9-1.7
Epididymis fat weight0.10.20.2-0.4
Glucose0.20.30.30.5
Heart weight2.02.92.9-1.7
Left kidney weight0.00.10.10.3
Right kidney weight0.10.40.4-0.6
Tail length2.06.06.02.5
Length with tail0.10.30.30.5
Length without tail1.73.83.8-2.0
Liver weight, left0.00.00.00.1
Liver weight, right0.10.10.1-0.3
Parametrial fat weight0.00.00.0-0.1
Retroperitoneal fat weight0.72.32.3-1.5
Intraocular pressure5.98.38.3-2.9
Extensor digitorum longus weight0.00.00.00.2
Soleus weight0.00.10.1-0.3
Tibialis anterior weight0.82.72.7-1.6
Tibia length0.00.10.10.3
Number of licking bursts0.50.60.60.8
Food consumed during 24 hour testing period7.59.09.03.0
Times rat made contact with spout0.20.20.20.5
Mean time between licks in bursts0.30.40.4-0.6
Mean num. licks in bursts0.10.20.2-0.4
Std. dev. time between licks in bursts0.00.10.10.2
Water consumed over 24 hours3.44.04.02.0
Indifference point 0 sec0.71.21.2-1.1
Indifference point AUC1.51.71.71.3
Indifference point function ln k1.72.42.4-1.5
Indifference point function log k1.72.42.4-1.5
Delay discounting total patch changes 0 sec0.91.41.4-1.2
Delay discounting total patch changes 12 sec0.30.40.40.6
Delay discounting total patch changes 18 sec1.62.22.21.5
Delay discounting total patch changes 24 sec0.50.60.60.8
Delay discounting total patch changes 6 sec0.10.10.10.4
Delay discounting time to switch 0 sec0.00.00.0-0.0
Delay discounting water rate 0 sec0.00.10.10.3
Delay discounting water rate 12 sec0.60.90.90.9
Delay discounting water rate 18 sec2.63.43.41.9
Delay discounting water rate 24 sec0.10.10.10.4
Delay discounting water rate 6 sec4.16.06.02.5
Locomotor activity0.20.30.3-0.5
Locomotor testing distance0.20.30.3-0.5
Locomotor testing rearing0.50.70.70.9
Light reinforcement 116.630.430.45.5
Light reinforcement 213.117.317.34.2
Reaction time number correct1.01.51.5-1.2
Reaction time mean minus median0.70.90.9-0.9
Reaction time mean minus median AUC1.01.21.2-1.1
Reaction time num false alarms4.76.56.5-2.6
Reaction time num false alarms AUC4.05.75.7-2.4
Reaction time trials correct on left1.01.51.5-1.2
Reaction time trials on left1.21.71.7-1.3
Reaction time mean2.53.53.5-1.9
Reaction time mean AUC2.63.43.4-1.8
Median of all reaction times2.53.43.4-1.8
Reaction time omissions2.23.03.0-1.7
Reaction time false alarm rate1.31.91.9-1.4
Reaction time premature initiation rate4.45.95.92.4
Reaction time premature initiations1.42.12.11.4
Std. dev. reaction times0.91.31.3-1.1
Reaction time trials completed1.21.71.7-1.3
Reaction time trials AUC1.21.81.8-1.3
Social response proportion0.10.10.1-0.2
Social responses0.10.20.2-0.4
Social time0.50.60.60.8
Conditioned locomotion0.00.00.00.2
Cocaine response after cond. corrected2.12.42.4-1.5
Cocaine response after cond. not corrected1.31.51.5-1.2
Cocaine response before conditioning2.02.52.51.6
Saline control response1.31.81.81.3
Condit. Reinf. active minus inactive responses0.20.30.3-0.5
Condit. Reinf. active-inactive response ratio0.10.10.1-0.4
Condit. Reinf. active responses0.10.10.1-0.3
Condit. Reinf. inactive responses0.30.30.3-0.6
Condit. Reinf. lever presses0.60.80.8-0.9
Condit. Reinf. lever reinforcers received0.30.40.4-0.6
Pavlov. Cond. lever latency0.30.50.5-0.7
Pavlov. Cond. magazine entry latency0.10.10.10.3
Pavlov. Cond. change in total contacts0.10.10.10.3
Pavlov. Cond. index score0.00.10.10.3
Pavlov. Cond. latency score0.00.10.10.2
Pavlov. Cond. lever contacts0.81.11.11.0
Pavlov. Cond. magazine entry number0.00.00.0-0.0
Pavlov. Cond. intertrial magazine entries0.40.50.50.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.3
Pavlov. Cond. response bias0.20.30.30.6
Conditioned reinforcement - actives0.80.80.8-0.9
Conditioned reinforcement - inactives0.91.01.0-1.0
Conditioned locomotion0.10.20.2-0.4
Intermittent access intake day 1-15 change3.03.03.01.7
Intermittent access intake escalation5.15.15.12.2
Intermittent access intake escalation 22.82.82.81.7
Intermitt. access day 1 inactive lever presses0.20.20.2-0.4
Intermitt. access day 15 inactive lever presses1.11.21.2-1.1
Intermitt. access escalation Index0.40.40.40.6
Intermittent access day 1 total infusions3.43.83.8-2.0
Intermittent access day 15 total infusions0.00.00.0-0.0
Intermittent access terminal intake (last 3 days)0.30.40.4-0.6
Intermittent access total infusions0.20.20.2-0.4
Intermittent access day 1 locomotion0.90.90.9-0.9
Intermittent access day 15 total locomotion0.50.60.6-0.8
Intermittent access total locomotion0.60.70.7-0.8
Intermittent access standard deviation0.20.30.30.5
Cocaine induced anxiety0.81.01.0-1.0
Post-drug Anxiety0.40.40.4-0.6
Baseline Anxiety0.30.30.30.6
Lifetime Intake0.30.30.3-0.6
Incentive Sensitization - Responses0.00.00.0-0.2
Incentive Sensitization - Breakpoint0.00.00.0-0.1
Progressive ratio test 1 active lever presses2.32.32.3-1.5
Progressive ratio test 1 breakpoint1.51.61.6-1.3
Progressive ratio test 1 inactive lever presses0.30.30.3-0.5
Progressive ratio test 2 active lever presses1.01.01.0-1.0
Progressive ratio test 2 breakpoint1.11.21.2-1.1
Progressive ratio test 2 inactive lever presses3.23.73.7-1.9
Total sessions with >9 infusions0.80.80.8-0.9
Short access day 1 total inactive lever presses0.10.10.10.3
Short access day 10 total inactive lever presses0.80.80.80.9
Short access day 1 total infusions2.62.82.8-1.7
Short access day 10 total infusions0.40.50.5-0.7
Short access total infusions0.20.30.3-0.5
Short access day 1 locomotion3.03.23.2-1.8
Short access day 10 total locomotion0.30.30.3-0.5
Short access total locomotion1.61.61.6-1.3
Compulsive drug intake0.90.90.90.9
One hour access (0.3 mA shock)0.10.10.1-0.3
One hour access (shock baseline)1.01.21.2-1.1
Number of responses in last shaping day7.37.47.4-2.7
Context. condit. distance diff. score4.45.45.4-2.3
Locomotion velocity, session 10.70.80.80.9
Locomotion distance, session 10.00.00.0-0.0
Locomotion velocity, session 20.00.00.00.1
Locomotion distance, session 20.20.30.3-0.6
Locomotion velocity, session 32.63.03.0-1.7
Locomotion distance, session 30.60.60.6-0.8
Stereotopy head waving bouts, day 30.70.80.8-0.9
Stereotopy head waving duration, day 31.21.41.4-1.2
Locomotion velocity, session 71.51.61.6-1.3
Locomotion distance, session 70.00.00.00.0
Stereotopy head waving bouts, day 70.70.80.8-0.9
Stereotopy head waving duration, day 70.00.10.10.2
Locomotion velocity, session 80.91.11.1-1.1
Locomotion distance, session 81.62.32.3-1.5
Degree of sensitization distance0.10.10.10.3
Degree of sensitization stereotypy0.80.80.8-0.9
Condit. Reinf. active minus inactive responses1.11.21.2-1.1
Condit. Reinf. active-inactive response ratio1.41.51.5-1.2
Condit. Reinf. active responses0.00.00.00.1
Condit. Reinf. inactive responses4.04.74.72.2
Incentive salience index mean0.20.30.30.5
Condit. Reinf. lever presses2.73.73.71.9
Time in familiar zone, hab. session 11.01.01.01.0
Time in novel zone, hab. session 11.01.01.0-1.0
Total zone transitions, hab. session 10.20.20.2-0.5
Total locomotion distance, hab. session 10.60.80.8-0.9
Locomotion velocity, hab. session 10.50.70.7-0.8
Time in familiar zone, hab. session 21.71.81.81.3
Time in novel zone, hab. session 24.44.54.5-2.1
Total zone transitions, hab. session 20.00.00.00.0
Total locomotion distance, hab. session 20.10.10.1-0.3
Locomotion velocity, hab. session 20.00.00.0-0.0
Novel to familiar place preference ratio1.51.51.5-1.2
Novelty place preference1.01.11.1-1.0
Time in novel zone, NPP test0.90.90.9-1.0
Total zone transitions, NPP test0.00.00.0-0.2
Total locomotion distance, NPP test0.20.30.3-0.5
Locomotion velocity, NPP test0.10.10.1-0.3
Pavlov. Cond. lever latency0.00.00.0-0.0
Pavlov. Cond. magazine entry latency0.10.10.1-0.3
Pavlov. Cond. change in total contacts1.21.31.31.2
Pavlov. Cond. index score0.10.10.1-0.3
Pavlov. Cond. latency score0.10.10.1-0.3
Pavlov. Cond. lever contacts0.00.00.00.0
Pavlov. Cond. magazine entry number0.00.00.0-0.0
Pavlov. Cond. intertrial magazine entries0.20.20.2-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.2-0.5
Pavlov. Cond. response bias0.00.00.0-0.0
Bone: apparent density1.42.32.31.5
Bone surface0.71.31.31.1
Bone volume2.13.53.51.9
Bone: connectivity density1.01.61.61.3
Bone: cortical apparent density0.30.40.4-0.6
Bone: cortical area0.20.20.20.5
Bone: cortical porosity0.00.00.0-0.1
Bone: cortical porosity0.00.00.00.1
Bone: cortical thickness0.00.00.0-0.1
Bone: cortical thickness0.10.10.1-0.3
Bone: cortical tissue density0.30.40.4-0.6
Bone: elastic displacement0.10.10.1-0.4
Bone: elastic work0.00.00.0-0.0
Bone: endosteal estimation0.00.00.0-0.1
Bone: endosteal perimeter0.00.10.1-0.3
Bone: final force1.62.72.71.6
Bone: final moment1.11.81.81.3
Bone: marrow area0.00.00.0-0.2
Bone: maximum diameter0.20.30.3-0.5
Bone: maximum force0.40.70.70.8
Bone: maximum moment0.20.40.40.6
Bone: minimum diameter1.01.91.91.4
Bone: periosteal estimation0.00.10.10.3
Bone: periosteal perimeter0.10.10.1-0.3
Bone: post-yield work0.20.20.20.5
Bone: stiffness0.40.60.60.8
Bone: tissue strength0.10.10.10.3
Bone: trabecular number1.21.81.81.4
Bone: trabecular spacing1.72.22.2-1.5
Bone: trabecular thickness3.13.73.71.9
Bone: trabecular tissue density0.30.40.4-0.6
Breakpoint value in progressive ratio session0.30.30.30.6
Distance traveled before self-admin1.21.31.3-1.1
Distance traveled after self-admin0.00.00.00.2
Delta time in closed arm before/after self-admin1.21.11.1-1.1
Delta time in open arm before/after self-admin2.22.12.11.4
Diff in mean of infusions in LGA sessions0.00.00.0-0.2
Extinction: sum of active levers before priming2.22.22.2-1.5
Active lever presses in extinction session 60.10.10.10.3
Delta distance traveled before/after self-admin1.41.51.51.2
Delta ambulatory time before/after self-admin2.83.13.11.8
Time in closed arm before self-admin3.54.04.02.0
Time in closed arm after self-admin1.31.41.41.2
Time in open arm before self-admin2.93.13.1-1.8
Time in open arm after self-admin1.11.21.2-1.1
Sum of active levers in priming session hrs 5-60.10.10.10.3
Time to tail flick, vehicle, before self-admin0.00.00.00.2
Time to tail flick, vehicle, after self-admin0.30.30.30.6
Time to tail flick, test, before self-admin1.21.21.2-1.1
Time to tail flick, test, after self-admin1.11.11.11.1
Delta time to tail flick, vehicle, before/after SA0.20.20.20.4
Delta time to tail flick, test, before/after SA2.01.81.81.3
Ambulatory time before self-admin1.11.21.2-1.1
Ambulatory time after self-admin0.91.01.01.0
Total heroin consumption0.00.00.0-0.1
Area under the delay curve0.40.40.4-0.6
Delay disc. indifference point, 0s delay1.31.41.41.2
Delay disc. indifference point, 16s delay0.80.80.8-0.9
Delay disc. indifference point, 2s delay0.91.01.0-1.0
Delay disc. indifference point, 24s delay0.00.00.0-0.0
Delay disc. indifference point, 4s delay0.10.10.1-0.4
Delay disc. indifference point, 8s delay1.21.21.2-1.1
Delay discount exponential model param0.40.50.50.7
Delay discount hyperbolic model param0.50.50.50.7
Fecal boli incidents, locomotor time 10.60.60.60.8
Change in fecal boli incidents, locomotor task0.00.00.0-0.1
Time >=10cm from walls, locomotor time 10.10.10.10.2
Bouts of movement, locomotor time 11.01.11.11.0
Total resting periods, locomotor time 10.40.50.50.7
Rest time, locomotor task time 10.20.30.30.5
Distance moved, locomotor task time 10.70.80.8-0.9
Vertical activity count, locomotor time 10.20.20.20.5
Time >=10cm from walls, locomotor time 20.40.40.4-0.7
Bouts of movement, locomotor time 20.10.10.1-0.4
Total resting periods, locomotor time 20.00.00.0-0.1
Rest time, locomotor task time 20.00.00.00.1
Distance moved, locomotor task time 21.31.51.5-1.2
Vertical activity count, locomotor time 20.10.10.10.4
Weight adjusted by age3.53.93.9-2.0
Seeking ratio, delayed vs. immediate footshock5.15.85.8-2.4
Locomotion in novel chamber0.70.90.9-0.9
Locomotion in novel chamber post-restriction0.10.10.10.3
Progressive ratio0.00.00.00.2
Food seeking constrained by brief footshock2.83.43.41.8
Seeking ratio, punishment vs. effort1.31.61.61.3
Run reversals in cocaine runway, females1.11.11.1-1.1
Run reversals in cocaine runway, males0.00.00.0-0.2
Latency to leave start box in cocaine runway0.30.30.3-0.6
Latency to leave start box in cocaine runway, F0.80.90.9-0.9
Latency to leave start box in cocaine runway, M1.21.21.21.1
Cd content in liver0.20.20.2-0.4
Co content in liver0.30.40.4-0.6
Cu content in liver0.10.10.1-0.3
Fe content in liver0.50.60.60.8
K content in liver0.10.10.1-0.4
Mg content in liver1.21.21.2-1.1
Mn content in liver1.92.22.2-1.5
Na content in liver0.00.00.00.2
Rb content in liver0.50.60.60.8
Se content in liver2.53.13.11.8
Sr content in liver0.00.00.00.1
Zn content in liver4.24.74.7-2.2