Homer2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000061450	0.06	0.04	2.7e-04	0.03	0.02	0.03	0.03	1.3e-04	1.2e-03	2.0e-04	6.4e-04
2	Adipose	mRNA stability	ENSRNOG00000061450	0.07	0.04	1.6e-04	0.01	0.03	0.02	0.02	5.6e-02	6.4e-04	1.4e-03	1.5e-03
3	Brain	gene expression	ENSRNOG00000061450	0.27	0.11	5.4e-14	0.14	0.16	0.17	0.16	5.7e-13	5.9e-15	2.1e-15	1.3e-14
4	Brain	mRNA stability	ENSRNOG00000061450	0.25	0.09	0.0e+00	0.14	0.19	0.19	0.19	3.2e-13	5.1e-17	2.7e-17	2.0e-17
5	IL	mRNA stability	ENSRNOG00000061450	0.57	0.16	4.4e-06	0.11	0.2	0.17	0.19	1.5e-03	1.7e-05	5.6e-05	2.3e-05
6	Liver	gene expression	ENSRNOG00000061450	0.4	0.11	0.0e+00	0.32	0.34	0.34	0.34	1.2e-35	2.5e-38	1.5e-38	2.1e-38
7	OFC	gene expression	ENSRNOG00000061450	0.14	0.09	8.7e-03	0.02	0.05	0.01	0.04	1.1e-01	2.1e-02	2.2e-01	5.3e-02
8	PL	mRNA stability	ENSRNOG00000061450	0.12	0.07	3.0e-04	0.07	0.05	0.05	0.06	8.8e-06	9.2e-05	8.7e-05	3.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
BMI with tail	0.3	1.1	1.7	-1.3	1.0	0.1	-1.3	-1.0	-1.2	1.1	-1.0
BMI without tail	0.7	1.5	4.8	-0.0	-1.3	-0.2	-0.9	-1.3	0.3	2.2	-1.7
Body weight	0.5	2.2	3.8	1.6	0.7	-2.0	1.7	1.7	1.3	1.0	1.4
Epididymis fat weight	1.1	2.5	5.0	0.9	2.2	-2.0	1.6	1.6	0.3	-0.1	2.2
Glucose	0.1	0.1	0.3	-0.2	0.4	0.3	-0.5	-0.5	-0.6	-0.2	0.1
Heart weight	0.2	0.3	0.9	-0.6	1.0	-0.2	-0.3	-0.3	-0.8	-0.5	0.4
Left kidney weight	0.8	2.4	6.4	-0.5	2.5	-0.9	0.3	1.0	-1.3	-2.3	2.0
Right kidney weight	0.2	0.4	1.1	-0.0	1.0	-0.7	0.2	0.5	-0.3	-0.8	1.0
Tail length	1.4	4.2	8.9	3.0	-1.7	-2.1	2.2	1.4	2.8	1.3	1.0
Length with tail	2.2	8.2	13.7	3.7	-0.2	-2.8	3.7	3.3	3.3	0.4	3.0
Length without tail	1.2	2.6	5.4	1.3	1.3	-1.1	2.0	2.3	1.0	-0.7	2.3
Liver weight, left	1.0	1.5	5.6	-0.4	2.4	-0.6	0.3	1.0	-1.0	-1.4	1.5
Liver weight, right	2.7	4.5	8.7	1.7	1.9	-2.2	2.6	2.8	1.1	-1.0	2.9
Parametrial fat weight	1.0	2.0	4.9	1.4	1.1	-2.2	1.2	1.1	1.0	1.4	1.4
Retroperitoneal fat weight	1.2	3.9	8.4	1.7	1.9	-2.9	2.0	2.1	1.3	1.5	2.1
Intraocular pressure	0.6	0.9	1.9	-0.4	-1.0	0.5	-0.8	-1.2	0.0	1.4	-1.4
Extensor digitorum longus weight	0.1	0.4	1.4	-0.1	-0.7	0.1	-0.4	-0.5	0.3	1.2	-0.8
Soleus weight	1.7	4.9	8.2	2.9	-0.4	-2.4	2.6	2.0	2.8	2.0	1.5
Tibialis anterior weight	0.2	0.8	1.6	1.1	-0.2	-0.5	0.9	0.8	1.2	1.3	0.3
Tibia length	0.7	2.1	5.8	-0.6	-2.4	1.3	-1.2	-1.9	-0.0	0.7	-1.9
Number of licking bursts	0.2	0.2	1.1	-0.2	0.0	0.3	-0.1	0.3	-0.3	-1.0	0.2
Food consumed during 24 hour testing period	0.2	0.3	1.3	0.3	-1.2	0.4	0.0	-0.1	0.5	-0.2	-0.4
Times rat made contact with spout	0.3	0.3	0.5	-0.6	0.7	0.6	-0.5	-0.1	-0.7	-0.6	-0.1
Mean time between licks in bursts	1.7	2.3	4.9	0.1	2.1	-1.4	0.8	1.4	-0.6	-2.2	2.0
Mean num. licks in bursts	0.1	0.2	0.7	-0.3	0.8	0.0	-0.3	-0.2	-0.4	0.5	-0.0
Std. dev. time between licks in bursts	0.3	0.3	0.9	-0.4	-0.9	0.7	-0.5	-0.4	-0.2	-0.7	-0.6
Water consumed over 24 hours	0.2	0.2	0.5	-0.6	0.2	0.7	-0.5	-0.1	-0.5	-0.4	-0.4
Indifference point 0 sec	0.6	0.9	2.4	1.0	-1.5	-0.1	0.4	0.1	1.3	1.2	-0.7
Indifference point AUC	0.4	0.5	2.5	-0.5	0.3	0.8	0.1	0.1	-0.5	-1.6	0.7
Indifference point function ln k	1.3	1.8	4.9	0.2	-1.4	0.3	-1.0	-1.5	0.3	2.2	-1.9
Indifference point function log k	1.3	1.8	4.9	0.2	-1.4	0.3	-1.0	-1.5	0.3	2.2	-1.9
Delay discounting total patch changes 0 sec	0.5	0.8	2.8	0.6	-1.7	0.3	-0.0	-0.4	0.9	1.0	-1.1
Delay discounting total patch changes 12 sec	1.2	1.6	4.8	0.2	0.8	-0.6	1.3	1.4	0.2	-2.2	1.9
Delay discounting total patch changes 18 sec	0.5	0.6	1.3	0.5	-0.1	-0.1	1.1	0.9	0.6	-1.0	1.1
Delay discounting total patch changes 24 sec	0.4	0.5	1.0	0.8	-0.8	0.0	1.0	0.8	1.0	-0.3	0.4
Delay discounting total patch changes 6 sec	0.5	0.8	1.9	1.1	-0.9	-0.2	1.3	0.8	1.4	0.3	0.4
Delay discounting time to switch 0 sec	0.6	0.9	2.1	0.7	-0.1	-1.0	1.4	1.1	0.9	-0.3	1.2
Delay discounting water rate 0 sec	0.7	1.1	2.1	-1.2	0.3	1.0	-1.4	-1.1	-1.2	0.2	-1.1
Delay discounting water rate 12 sec	1.1	1.6	7.2	-0.2	-0.5	0.7	-0.9	-0.8	0.2	2.7	-1.8
Delay discounting water rate 18 sec	2.0	2.6	6.4	-1.3	-0.7	1.4	-2.1	-1.7	-0.9	1.5	-2.5
Delay discounting water rate 24 sec	0.2	0.3	0.9	-0.2	0.1	0.3	-0.7	-0.2	-0.3	0.9	-0.8
Delay discounting water rate 6 sec	0.4	0.6	1.3	-0.7	0.7	-0.1	-1.1	-0.4	-0.8	1.0	-1.0
Locomotor activity	1.9	3.1	6.0	-1.7	-1.3	1.9	-2.3	-1.9	-1.2	0.6	-2.4
Locomotor testing distance	1.4	2.3	4.7	-1.6	-0.9	1.6	-1.9	-1.5	-0.9	1.1	-2.2
Locomotor testing rearing	0.7	1.1	2.9	-0.1	-1.6	0.6	-0.4	-0.5	0.7	1.7	-1.4
Light reinforcement 1	1.2	2.2	4.8	0.9	0.4	-1.3	1.6	2.0	0.6	-2.2	1.7
Light reinforcement 2	2.0	2.7	6.6	0.6	1.4	-1.2	1.4	2.0	0.1	-2.6	2.2
Reaction time number correct	2.1	3.0	5.7	-2.3	0.9	1.7	-2.0	-1.4	-2.4	-1.3	-1.2
Reaction time mean minus median	0.9	1.1	2.5	1.3	-1.6	-0.2	0.7	-0.1	1.5	1.4	-0.2
Reaction time mean minus median AUC	0.4	0.5	1.1	1.0	-0.9	-0.3	0.3	-0.2	0.9	1.0	-0.1
Reaction time num false alarms	2.5	3.5	14.2	-0.9	2.2	-0.4	0.6	0.9	-1.5	-3.8	2.1
Reaction time num false alarms AUC	2.1	3.0	12.5	-1.6	1.8	0.3	-0.3	0.1	-2.0	-3.5	1.1
Reaction time trials correct on left	2.1	3.0	5.7	-2.3	0.9	1.7	-2.0	-1.4	-2.4	-1.3	-1.2
Reaction time trials on left	2.2	3.2	6.1	-2.3	0.9	1.7	-2.1	-1.5	-2.5	-1.4	-1.2
Reaction time mean	0.1	0.1	0.2	0.4	-0.1	-0.0	0.2	0.2	0.4	0.4	0.4
Reaction time mean AUC	0.2	0.2	0.5	0.7	-0.3	-0.1	0.3	0.2	0.7	0.7	0.3
Median of all reaction times	0.1	0.1	0.5	0.1	0.5	-0.1	0.2	0.3	0.0	-0.1	0.7
Reaction time omissions	0.4	0.6	1.1	-0.7	-0.0	0.7	-1.0	-1.0	-1.0	-0.6	-0.6
Reaction time false alarm rate	1.1	1.5	5.8	-0.3	1.3	-0.5	0.7	0.8	-0.6	-2.4	1.6
Reaction time premature initiation rate	0.5	0.7	1.6	0.7	-1.2	-0.0	0.7	0.6	1.3	1.1	-0.4
Reaction time premature initiations	0.2	0.2	0.8	-0.6	-0.4	0.7	-0.4	-0.1	-0.2	0.2	-0.9
Std. dev. reaction times	0.8	1.1	3.1	0.7	-1.8	0.5	-0.2	-0.7	1.0	1.6	-0.9
Reaction time trials completed	2.2	3.2	6.1	-2.3	0.9	1.7	-2.1	-1.5	-2.5	-1.4	-1.2
Reaction time trials AUC	2.1	3.0	6.2	-2.3	1.2	1.6	-2.0	-1.3	-2.5	-1.5	-1.0
Social response proportion	0.3	0.3	0.6	-0.7	0.4	0.0	-0.7	-0.6	-0.8	0.2	-0.6
Social responses	1.2	1.6	2.6	-1.6	-0.2	1.2	-1.6	-1.4	-1.4	-0.5	-1.4
Social time	1.7	2.2	3.6	-1.2	-1.4	1.5	-1.9	-1.9	-1.1	-0.5	-1.8
Conditioned locomotion	0.9	1.1	2.0	0.9	1.0	-1.4	1.2	1.1	0.5	-0.3	1.4
Cocaine response after cond. corrected	0.2	0.2	0.6	0.6	0.8	-0.7	0.3	0.2	-0.1	-0.1	0.5
Cocaine response after cond. not corrected	0.0	0.1	0.2	0.3	0.4	-0.3	0.0	-0.0	-0.2	0.1	0.1
Cocaine response before conditioning	0.1	0.1	0.3	-0.2	-0.6	0.3	-0.0	-0.0	0.1	-0.3	-0.3
Saline control response	2.6	3.4	8.6	1.7	-2.8	-0.2	0.9	0.1	2.5	2.9	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.4	0.4	-0.6	0.7	0.5	0.4	0.2	0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	2.0	-0.5	1.4	-0.5	0.2	0.3	-0.7	-0.7	0.6
Condit. Reinf. active responses	0.8	1.1	2.2	1.3	-0.8	-0.8	1.2	0.6	1.5	1.3	0.2
Condit. Reinf. inactive responses	3.1	3.8	7.8	2.3	-2.8	-0.5	1.2	0.4	2.8	2.8	-0.6
Condit. Reinf. lever presses	2.5	3.4	7.1	-0.3	-2.7	1.6	-1.0	-1.9	0.6	2.5	-2.5
Condit. Reinf. lever reinforcers received	1.2	1.6	3.4	1.6	-1.1	-0.9	1.4	0.7	1.8	1.6	0.2
Pavlov. Cond. lever latency	2.3	3.1	10.1	-1.5	2.5	0.1	-0.7	0.4	-2.1	-3.2	1.1
Pavlov. Cond. magazine entry latency	0.8	0.9	4.2	0.6	-1.0	-0.5	0.2	-0.2	1.0	2.1	-0.5
Pavlov. Cond. change in total contacts	2.9	4.0	11.1	2.3	-2.4	-0.9	1.3	0.1	2.7	3.3	-0.5
Pavlov. Cond. index score	2.7	3.6	12.6	1.6	-2.5	-0.6	0.7	-0.5	2.2	3.5	-1.1
Pavlov. Cond. latency score	2.5	3.2	11.0	1.6	-2.4	-0.5	0.6	-0.5	2.1	3.3	-1.0
Pavlov. Cond. lever contacts	3.0	4.2	13.5	1.4	-3.1	0.2	0.3	-1.0	2.2	3.7	-1.7
Pavlov. Cond. magazine entry number	1.1	1.3	5.1	-0.3	1.5	0.1	0.2	0.9	-0.9	-2.3	1.1
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.5	-0.6	0.3	0.4	0.3	0.6	0.4	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.4	12.0	1.5	-2.5	-0.5	0.6	-0.6	2.1	3.5	-1.2
Pavlov. Cond. response bias	2.9	4.0	13.5	1.6	-2.8	-0.2	0.6	-0.7	2.3	3.7	-1.3
Conditioned reinforcement - actives	0.4	0.4	1.1	-0.2	1.0	-0.2	-0.1	-0.2	-0.8	-0.8	1.1
Conditioned reinforcement - inactives	2.1	2.3	8.5	1.0	1.0	-1.6	1.7	1.2	0.4	-1.1	2.9
Conditioned locomotion	0.6	0.7	1.6	-0.6	1.2	-0.2	-0.1	-0.0	-1.0	-1.1	1.1
Intermittent access intake day 1-15 change	0.5	0.5	1.4	1.2	-0.8	-0.0	0.7	0.1	1.0	0.5	0.3
Intermittent access intake escalation	0.1	0.1	0.3	0.6	-0.2	0.1	0.3	-0.0	0.3	-0.1	0.5
Intermittent access intake escalation 2	0.6	0.6	1.7	0.9	-0.1	-0.5	1.0	0.5	0.6	-0.4	1.3
Intermitt. access day 1 inactive lever presses	2.7	2.9	4.7	1.8	0.2	-1.9	2.2	1.8	1.8	1.1	2.0
Intermitt. access day 15 inactive lever presses	1.0	1.1	3.6	0.7	0.7	-1.3	1.2	0.8	0.4	-0.3	1.9
Intermitt. access escalation Index	0.7	0.6	1.3	1.1	-0.8	-0.3	0.4	0.3	1.1	1.1	-0.3
Intermittent access day 1 total infusions	0.9	1.0	3.1	1.0	0.5	-1.4	1.1	0.6	0.5	-0.0	1.8
Intermittent access day 15 total infusions	1.0	1.1	3.0	1.4	0.3	-1.2	1.2	0.5	0.8	0.3	1.7
Intermittent access terminal intake (last 3 days)	1.0	1.1	3.1	1.4	0.2	-1.1	1.2	0.4	0.8	0.2	1.8
Intermittent access total infusions	1.1	1.2	4.4	1.0	0.8	-1.3	1.1	0.5	0.4	-0.2	2.1
Intermittent access day 1 locomotion	0.7	0.8	1.5	1.0	0.2	-1.2	1.0	0.5	0.7	0.5	1.2
Intermittent access day 15 total locomotion	1.1	1.2	3.1	1.2	0.6	-1.5	1.1	0.6	0.7	0.3	1.8
Intermittent access total locomotion	0.7	0.8	3.0	0.8	0.5	-1.1	1.0	0.5	0.4	-0.2	1.7
Intermittent access standard deviation	0.9	1.0	1.9	1.3	-0.6	-0.8	1.4	0.6	1.1	-0.3	1.3
Cocaine induced anxiety	0.1	0.1	0.4	-0.5	0.1	0.0	-0.2	-0.2	-0.4	-0.6	0.1
Post-drug Anxiety	0.6	0.6	1.7	0.8	0.2	-0.8	1.1	0.7	0.7	0.0	1.3
Baseline Anxiety	1.8	1.8	4.3	2.0	-0.5	-0.7	1.2	0.9	1.9	2.1	0.3
Lifetime Intake	0.8	0.9	3.3	0.9	0.7	-1.3	0.9	0.3	0.3	-0.0	1.8
Incentive Sensitization - Responses	0.5	0.5	1.8	0.2	0.6	-0.9	0.8	0.4	0.1	-0.4	1.3
Incentive Sensitization - Breakpoint	0.6	0.6	2.1	0.2	0.6	-0.9	0.9	0.5	0.1	-0.4	1.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	0.1	0.2	-0.6	-0.2	-0.5	-0.3	-0.2	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.3	-0.1	-0.5	-0.0	-0.5	-0.0	0.1	0.2
Progressive ratio test 1 inactive lever presses	2.9	3.1	5.8	1.8	0.6	-2.4	2.1	1.5	1.5	1.1	2.3
Progressive ratio test 2 active lever presses	0.7	0.8	3.1	0.5	0.7	-1.1	0.9	0.3	0.1	-0.4	1.8
Progressive ratio test 2 breakpoint	0.8	0.8	3.2	0.7	0.5	-1.2	1.1	0.4	0.3	-0.3	1.8
Progressive ratio test 2 inactive lever presses	2.3	2.6	7.1	1.4	0.8	-2.0	2.0	1.5	1.1	0.1	2.7
Total sessions with >9 infusions	1.0	1.1	3.6	-0.1	1.3	-0.9	0.3	0.2	-0.8	-1.4	1.9
Short access day 1 total inactive lever presses	2.4	2.7	7.3	1.2	1.1	-2.3	1.9	1.5	0.9	0.1	2.7
Short access day 10 total inactive lever presses	3.5	3.8	6.9	1.8	0.6	-2.0	2.6	2.4	1.8	0.6	2.6
Short access day 1 total infusions	1.2	1.3	3.3	1.2	0.4	-1.6	1.3	0.8	0.8	-0.1	1.8
Short access day 10 total infusions	0.9	1.0	2.0	1.4	-0.3	-1.4	1.0	0.4	1.1	0.7	0.9
Short access total infusions	1.0	1.1	2.3	1.4	-0.1	-1.5	1.1	0.5	1.0	0.5	1.3
Short access day 1 locomotion	2.0	2.2	3.8	1.8	-0.1	-1.6	1.8	1.2	1.5	0.4	1.9
Short access day 10 total locomotion	0.4	0.4	0.9	1.0	-0.7	-0.1	0.9	0.1	0.8	0.1	0.7
Short access total locomotion	1.2	1.2	2.2	1.4	-0.4	-1.2	1.4	0.7	1.2	-0.1	1.5
Compulsive drug intake	0.1	0.1	0.4	-0.1	0.7	-0.2	0.0	0.4	-0.3	-0.3	0.4
One hour access (0.3 mA shock)	0.5	0.5	2.1	0.6	0.6	-0.9	0.7	0.2	0.2	-0.0	1.4
One hour access (shock baseline)	0.2	0.2	1.0	0.5	0.2	-0.5	0.4	-0.3	0.1	-0.1	1.0
Number of responses in last shaping day	0.1	0.1	0.3	-0.1	0.2	-0.4	0.1	0.1	-0.1	-0.5	0.5
Context. condit. distance diff. score	0.1	0.1	0.4	-0.3	-0.1	-0.4	-0.3	0.0	-0.3	-0.6	-0.3
Locomotion velocity, session 1	0.6	0.7	2.8	-1.0	-0.3	1.7	-0.5	-0.5	-0.3	0.4	-0.9
Locomotion distance, session 1	0.1	0.1	0.3	-0.2	-0.5	0.3	0.1	0.1	0.3	0.4	-0.4
Locomotion velocity, session 2	0.2	0.2	0.6	0.2	-0.2	0.8	0.4	0.5	0.5	0.3	0.1
Locomotion distance, session 2	0.0	0.0	0.0	-0.1	-0.2	0.1	0.2	0.0	0.1	-0.0	-0.1
Locomotion velocity, session 3	1.0	1.1	3.7	-0.1	-1.9	0.5	-0.5	-1.1	0.5	1.2	-1.3
Locomotion distance, session 3	1.9	2.0	7.0	0.2	-2.7	0.7	-0.7	-1.2	0.8	1.6	-1.9
Stereotopy head waving bouts, day 3	1.9	2.3	6.5	-0.0	1.9	-1.1	0.9	1.5	-0.5	-2.5	2.0
Stereotopy head waving duration, day 3	1.3	1.6	3.1	-1.6	-0.2	1.8	-1.5	-1.4	-1.3	-0.4	-1.2
Locomotion velocity, session 7	1.3	1.4	5.0	0.2	-1.6	0.2	-0.2	-0.9	0.8	2.2	-1.4
Locomotion distance, session 7	0.6	0.8	1.8	-0.3	-1.2	0.6	-0.6	-0.8	0.2	1.3	-1.3
Stereotopy head waving bouts, day 7	0.3	0.3	1.2	-0.6	0.3	0.1	-0.3	-0.6	-0.8	-1.1	0.1
Stereotopy head waving duration, day 7	0.5	0.6	1.5	-0.6	-0.7	0.7	-0.8	-1.2	-0.5	0.0	-0.9
Locomotion velocity, session 8	0.9	1.1	2.6	-1.0	-0.8	0.9	-1.1	-1.1	-0.5	1.1	-1.6
Locomotion distance, session 8	0.1	0.1	0.3	-0.1	-0.3	-0.4	0.3	0.4	0.1	-0.6	0.1
Degree of sensitization distance	0.1	0.1	0.7	-0.4	0.8	0.2	-0.1	0.1	-0.4	-0.0	0.3
Degree of sensitization stereotypy	0.1	0.1	0.4	-0.3	0.0	-0.0	-0.2	-0.6	-0.4	-0.3	-0.1
Condit. Reinf. active minus inactive responses	0.8	0.9	2.2	1.0	0.2	-0.7	1.5	0.9	1.1	0.4	1.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.3	-0.8	-0.1	0.6	0.0	0.6	0.1	0.0
Condit. Reinf. active responses	0.9	1.0	2.4	1.0	0.8	-0.7	1.6	1.1	0.8	0.1	1.4
Condit. Reinf. inactive responses	0.2	0.2	0.6	0.4	0.8	-0.1	0.6	0.5	0.2	0.1	0.7
Incentive salience index mean	1.8	2.2	4.0	1.9	-0.1	-1.3	2.0	1.4	1.9	1.2	1.3
Condit. Reinf. lever presses	3.0	4.0	7.0	2.6	-0.6	-1.9	2.2	1.5	2.6	2.5	1.1
Time in familiar zone, hab. session 1	0.1	0.1	0.5	-0.2	-0.4	0.7	-0.1	0.3	0.1	0.2	-0.4
Time in novel zone, hab. session 1	0.2	0.2	0.5	0.0	0.7	-0.7	0.1	-0.2	-0.3	-0.3	0.5
Total zone transitions, hab. session 1	1.7	2.4	6.7	1.0	-2.5	0.2	0.1	-0.5	1.7	2.6	-1.4
Total locomotion distance, hab. session 1	6.9	9.9	17.2	2.9	2.1	-3.7	3.8	3.9	2.1	-1.4	4.1
Locomotion velocity, hab. session 1	7.9	11.4	18.5	3.3	2.0	-4.1	4.1	4.1	2.5	-1.2	4.3
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.2	0.2	-0.5	-0.0	0.0	-0.2	-0.5	0.3
Time in novel zone, hab. session 2	0.2	0.2	0.7	-0.5	-0.1	0.8	-0.3	-0.4	-0.2	0.4	-0.5
Total zone transitions, hab. session 2	2.0	2.6	7.9	0.8	-2.8	0.6	-0.2	-0.9	1.5	2.5	-1.6
Total locomotion distance, hab. session 2	5.6	7.4	12.7	2.6	1.4	-3.4	3.3	3.1	1.9	-1.4	3.6
Locomotion velocity, hab. session 2	6.2	8.4	13.8	2.9	1.4	-3.6	3.5	3.4	2.2	-1.3	3.7
Novel to familiar place preference ratio	0.9	0.9	1.7	-0.7	-1.3	1.1	-0.8	-1.3	-0.2	0.5	-1.2
Novelty place preference	1.0	1.1	2.1	-0.8	-1.1	1.3	-0.9	-1.4	-0.3	0.5	-1.3
Time in novel zone, NPP test	1.3	1.4	2.7	-1.0	-1.1	1.4	-1.1	-1.6	-0.5	0.7	-1.5
Total zone transitions, NPP test	0.5	0.8	1.9	0.9	-0.9	-0.5	0.7	0.5	1.3	1.4	-0.1
Total locomotion distance, NPP test	9.4	13.1	24.8	2.6	3.3	-4.3	4.0	4.3	1.5	-2.6	5.0
Locomotion velocity, NPP test	9.7	13.9	26.5	2.7	3.3	-4.3	4.1	4.5	1.6	-2.8	5.1
Pavlov. Cond. lever latency	2.9	3.6	5.8	-2.4	0.4	2.3	-2.2	-1.9	-2.3	-1.5	-1.3
Pavlov. Cond. magazine entry latency	6.2	8.0	12.5	3.5	-0.0	-3.5	3.5	2.9	3.3	1.6	2.4
Pavlov. Cond. change in total contacts	7.5	8.0	12.9	3.0	1.2	-3.5	3.6	3.4	2.5	-0.1	3.3
Pavlov. Cond. index score	5.1	6.5	10.3	3.2	-0.3	-3.1	3.0	2.6	3.0	1.7	2.0
Pavlov. Cond. latency score	4.9	6.2	10.3	3.2	-0.5	-3.0	2.9	2.4	3.1	1.9	1.7
Pavlov. Cond. lever contacts	3.3	3.9	6.2	2.5	-0.3	-2.5	2.4	1.9	2.3	1.4	1.4
Pavlov. Cond. magazine entry number	4.1	5.1	8.0	-2.8	0.4	2.8	-2.6	-2.1	-2.8	-1.9	-1.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.9	-0.6	-0.2	1.0	-0.1	-0.2	-0.2	-0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	5.1	6.4	9.7	3.1	0.1	-3.1	3.1	2.8	2.9	1.3	2.2
Pavlov. Cond. response bias	4.6	5.7	10.7	2.7	0.7	-3.3	3.0	2.6	2.3	0.7	2.4
Bone: apparent density	0.5	0.8	3.0	-0.1	0.9	-0.4	0.6	0.9	-0.3	-1.7	1.0
Bone surface	0.1	0.1	0.7	0.1	-0.6	-0.2	0.1	-0.1	0.1	-0.8	-0.1
Bone volume	0.1	0.2	0.5	0.4	-0.4	-0.6	0.4	0.2	0.3	-0.7	0.2
Bone: connectivity density	0.8	1.3	5.4	-1.0	1.3	0.3	0.1	0.7	-1.0	-2.3	0.8
Bone: cortical apparent density	0.3	0.4	1.2	0.1	0.9	-0.2	0.7	1.1	0.4	0.5	0.7
Bone: cortical area	2.7	4.1	8.6	2.9	-1.0	-2.6	2.3	1.7	2.4	0.4	1.5
Bone: cortical porosity	0.9	0.9	1.8	-1.0	0.3	0.8	-1.3	-1.3	-1.3	-0.6	-0.6
Bone: cortical porosity	1.0	1.1	2.0	-1.2	0.3	0.8	-1.3	-1.3	-1.4	-0.8	-0.6
Bone: cortical thickness	1.7	2.9	5.9	2.4	-0.3	-2.3	2.0	1.4	1.9	0.6	1.4
Bone: cortical thickness	1.9	2.2	6.1	0.7	2.0	-2.5	1.0	1.3	-0.1	-1.1	1.9
Bone: cortical tissue density	0.3	0.4	1.2	0.0	1.0	-0.1	0.7	1.1	0.3	0.4	0.7
Bone: elastic displacement	2.5	2.8	8.8	0.5	3.0	-0.9	1.3	2.0	-0.2	-1.2	2.3
Bone: elastic work	1.0	1.3	2.2	1.2	1.1	-1.4	1.3	1.3	0.7	0.1	1.5
Bone: endosteal estimation	0.3	0.7	3.5	-0.7	-0.4	-0.1	-0.6	-0.6	-0.8	-1.9	-0.1
Bone: endosteal perimeter	0.2	0.4	2.0	0.4	-0.2	-0.6	0.3	0.1	-0.0	-1.4	0.6
Bone: final force	0.6	0.9	1.5	1.2	-0.3	-1.2	1.1	1.1	0.9	-0.6	0.9
Bone: final moment	0.6	1.0	1.5	1.2	-0.1	-1.2	1.2	1.2	0.8	-0.7	1.0
Bone: marrow area	0.4	0.8	3.7	-0.8	-0.4	-0.0	-0.7	-0.7	-0.9	-1.9	-0.2
Bone: maximum diameter	0.7	1.3	2.9	1.7	-1.7	-1.3	0.9	0.1	1.4	0.1	0.3
Bone: maximum force	0.6	1.0	3.0	1.3	-0.6	-1.7	1.0	0.7	1.0	-0.2	0.8
Bone: maximum moment	0.6	1.0	2.9	1.3	-0.4	-1.7	1.1	0.7	1.0	-0.2	0.9
Bone: minimum diameter	0.8	1.5	3.8	0.8	0.3	-1.6	1.1	1.0	0.3	-1.9	1.5
Bone: periosteal estimation	0.5	1.0	2.6	1.3	-1.0	-1.6	0.9	0.5	0.9	-0.8	0.7
Bone: periosteal perimeter	0.9	1.5	3.3	1.8	-0.7	-1.7	1.3	0.8	1.3	-0.3	1.0
Bone: post-yield work	0.5	0.7	3.0	0.3	-1.7	-0.6	-0.1	-0.8	0.6	0.6	-0.8
Bone: stiffness	0.8	1.2	4.5	1.3	-0.4	-2.1	1.1	0.9	1.0	-0.3	0.8
Bone: tissue strength	2.2	2.1	3.7	-0.9	-1.6	1.9	-1.4	-1.7	-0.5	1.0	-1.9
Bone: trabecular number	1.0	1.6	7.5	-1.1	1.2	0.3	-0.0	0.5	-1.2	-2.7	0.9
Bone: trabecular spacing	1.3	1.7	5.1	0.1	-1.6	0.9	-0.9	-1.2	0.4	2.3	-1.7
Bone: trabecular thickness	1.4	1.7	3.2	1.5	0.7	-1.8	1.6	1.4	0.9	-0.4	1.5
Bone: trabecular tissue density	1.4	1.9	4.8	1.6	-2.2	-0.1	0.8	0.1	1.9	1.9	-0.4
Breakpoint value in progressive ratio session	0.4	0.4	1.0	0.5	-0.8	0.0	0.3	0.3	0.9	1.0	-0.5
Distance traveled before self-admin	4.4	4.7	8.8	2.9	-1.0	-2.0	2.6	2.0	3.0	1.6	1.5
Distance traveled after self-admin	3.9	4.3	7.4	2.6	-0.6	-1.8	2.7	2.4	2.5	0.2	2.1
Delta time in closed arm before/after self-admin	1.4	1.3	3.2	-1.5	1.1	0.5	-1.1	-1.1	-1.8	-1.1	-0.1
Delta time in open arm before/after self-admin	1.8	1.7	4.9	1.3	-1.5	0.1	0.6	0.6	1.9	2.2	-0.8
Diff in mean of infusions in LGA sessions	0.3	0.4	1.0	0.7	-1.0	-0.2	0.5	0.5	0.9	0.2	-0.2
Extinction: sum of active levers before priming	0.5	0.5	1.5	-0.5	1.2	-0.4	0.1	0.6	-0.5	-0.7	1.0
Active lever presses in extinction session 6	0.4	0.4	1.2	-0.6	1.1	0.0	-0.0	0.6	-0.6	-0.6	0.5
Delta distance traveled before/after self-admin	0.6	0.6	2.4	-0.9	-0.1	0.9	-0.5	-0.4	-0.9	-1.6	-0.1
Delta ambulatory time before/after self-admin	0.7	0.7	2.8	-1.0	0.5	0.6	-0.4	-0.2	-1.1	-1.7	0.3
Time in closed arm before self-admin	1.9	2.2	4.3	1.9	-0.7	-1.0	2.0	1.4	2.1	0.8	1.3
Time in closed arm after self-admin	0.5	0.6	2.0	0.5	0.4	-0.6	1.0	0.4	0.3	-0.6	1.4
Time in open arm before self-admin	1.3	1.4	3.3	-1.3	1.6	-0.1	-0.7	-0.3	-1.8	-1.6	0.5
Time in open arm after self-admin	0.2	0.3	1.0	0.3	-0.1	-0.2	-0.2	0.5	0.4	1.0	-0.7
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.4	-0.3	0.7	-0.2	-0.2	-0.0	-0.5	-0.4	0.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.9	0.1	0.9	-0.6	0.3	0.5	-0.0	-0.1	0.9
Time to tail flick, vehicle, after self-admin	0.7	0.8	2.6	1.1	-1.6	-0.1	0.6	-0.2	1.2	0.6	-0.5
Time to tail flick, test, before self-admin	1.8	1.8	5.8	0.5	-2.4	1.3	-0.5	-1.2	0.8	0.8	-1.9
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.2	0.1	0.2	-0.1	-0.1	-0.1	0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	2.9	2.8	9.6	1.1	-3.1	0.6	-0.3	-1.2	1.3	1.5	-2.4
Delta time to tail flick, test, before/after SA	1.0	0.9	2.9	-0.7	1.7	-0.5	-0.1	0.5	-1.0	-0.9	1.1
Ambulatory time before self-admin	3.8	4.0	6.4	2.5	-0.3	-2.1	2.4	2.1	2.5	1.4	1.6
Ambulatory time after self-admin	3.5	3.8	6.8	2.4	-0.3	-1.7	2.6	2.3	2.3	0.3	2.1
Total heroin consumption	0.4	0.5	1.5	1.2	-0.3	-0.5	0.7	0.6	0.8	0.6	0.2
Area under the delay curve	0.5	0.6	1.4	0.9	-0.7	-0.4	0.6	0.1	1.1	1.2	0.1
Delay disc. indifference point, 0s delay	0.4	0.5	1.3	0.4	0.7	-0.8	0.7	0.7	0.2	-0.5	1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.1	-0.6	0.3	0.0	-0.4	0.3	0.6	-0.2
Delay disc. indifference point, 2s delay	0.9	1.0	2.0	-0.0	-1.4	1.1	-0.7	-1.0	0.3	1.1	-1.4
Delay disc. indifference point, 24s delay	0.3	0.3	0.7	0.5	-0.0	-0.4	0.7	0.7	0.6	0.0	0.8
Delay disc. indifference point, 4s delay	2.9	3.1	6.5	2.3	-1.7	-1.1	1.5	0.8	2.6	2.4	0.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.7	0.0	-0.6	0.4	-0.0	0.5	0.7	0.4
Delay discount exponential model param	0.8	0.8	1.7	-1.1	0.8	0.5	-0.8	-0.3	-1.3	-1.3	-0.2
Delay discount hyperbolic model param	0.7	0.8	2.0	-1.1	1.1	0.3	-0.6	-0.0	-1.3	-1.4	0.1
Fecal boli incidents, locomotor time 1	1.1	1.2	2.7	0.1	1.6	-0.4	0.7	1.0	-0.4	-1.6	1.6
Change in fecal boli incidents, locomotor task	0.5	0.4	1.0	-0.2	-0.7	0.1	-0.5	-0.9	0.0	1.0	-1.0
Time >=10cm from walls, locomotor time 1	0.9	0.9	3.5	0.9	-0.9	0.2	0.3	0.2	1.2	1.9	-0.7
Bouts of movement, locomotor time 1	0.6	0.7	1.5	0.7	0.8	-1.0	1.0	0.9	0.4	-0.3	1.2
Total resting periods, locomotor time 1	1.1	1.2	2.5	0.8	1.0	-1.3	1.2	1.3	0.4	-0.6	1.6
Rest time, locomotor task time 1	0.8	0.9	1.8	0.8	0.4	-0.9	1.1	1.0	0.4	-1.2	1.3
Distance moved, locomotor task time 1	0.3	0.3	1.2	-0.1	-0.4	0.2	-0.5	-0.4	0.1	1.1	-0.7
Vertical activity count, locomotor time 1	0.5	0.5	1.1	-0.2	-0.8	0.8	-0.6	-0.5	0.2	0.8	-1.1
Time >=10cm from walls, locomotor time 2	0.4	0.5	1.2	0.6	-1.1	0.5	0.2	-0.2	0.8	0.8	-0.6
Bouts of movement, locomotor time 2	0.5	0.6	2.0	-0.6	0.0	0.6	-0.5	-0.8	-0.9	-1.4	0.0
Total resting periods, locomotor time 2	0.9	1.0	3.8	-0.9	0.4	0.7	-0.6	-0.8	-1.3	-2.0	0.2
Rest time, locomotor task time 2	1.4	1.6	4.8	0.0	1.6	-0.6	0.8	1.1	-0.5	-2.2	1.8
Distance moved, locomotor task time 2	0.5	0.6	1.5	0.8	-1.2	-0.0	0.3	-0.1	1.0	1.2	-0.5
Vertical activity count, locomotor time 2	0.2	0.3	0.9	0.3	-1.0	0.3	-0.1	-0.1	0.5	0.6	-0.6
Weight adjusted by age	0.1	0.1	0.4	0.2	0.1	-0.5	0.2	0.1	-0.1	-0.6	0.6
Seeking ratio, delayed vs. immediate footshock	4.9	5.6	14.5	1.2	3.0	-2.3	2.5	2.3	0.4	-1.5	3.8
Locomotion in novel chamber	0.7	0.8	1.6	0.9	-0.4	-1.3	1.0	0.8	1.1	0.6	0.8
Locomotion in novel chamber post-restriction	0.2	0.3	0.7	-0.5	-0.2	0.2	-0.8	-0.6	-0.5	0.1	-0.6
Progressive ratio	0.3	0.3	0.7	-0.7	0.6	-0.3	-0.5	-0.1	-0.9	-0.8	0.2
Food seeking constrained by brief footshock	0.6	0.8	1.7	1.2	-0.6	-0.3	1.0	0.7	1.3	1.0	-0.3
Seeking ratio, punishment vs. effort	1.0	1.3	3.1	1.6	-0.8	-0.1	1.4	0.8	1.8	1.2	0.0
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.3	0.0	-0.5	0.3	0.3	0.2	-0.5	0.6
Run reversals in cocaine runway, males	1.4	1.3	3.2	1.2	0.2	-1.2	1.2	0.9	1.3	1.8	0.7
Latency to leave start box in cocaine runway	1.3	1.4	3.0	1.7	-1.3	-0.0	1.5	0.7	1.7	-0.0	0.6
Latency to leave start box in cocaine runway, F	0.5	0.5	1.0	1.0	-0.8	0.1	1.0	0.4	0.9	-0.5	0.6
Latency to leave start box in cocaine runway, M	0.6	0.6	1.4	1.2	-0.8	-0.2	0.9	0.6	1.2	0.1	0.3
Cd content in liver	1.9	2.1	6.3	-0.3	2.5	-1.4	0.5	0.8	-1.1	-1.9	1.8
Co content in liver	0.4	0.4	1.6	-0.5	1.3	-0.6	-0.2	0.1	-0.8	-0.7	0.4
Cu content in liver	0.7	0.9	1.9	1.3	-1.0	-0.2	0.7	0.6	1.4	1.2	-0.2
Fe content in liver	0.1	0.1	0.3	0.3	-0.6	0.6	0.1	-0.1	0.3	0.0	-0.2
K content in liver	0.8	0.8	3.8	0.5	-1.9	0.5	-0.1	-0.3	0.9	0.8	-0.9
Mg content in liver	1.1	1.2	3.5	-0.3	-1.9	1.2	-0.9	-0.8	0.3	0.8	-1.5
Mn content in liver	0.2	0.2	0.4	0.6	0.4	-0.5	0.5	0.4	0.4	0.2	0.6
Na content in liver	2.9	3.1	11.1	0.2	-3.3	2.1	-0.9	-1.0	1.0	1.3	-2.3
Rb content in liver	0.8	1.0	1.6	-1.1	-0.5	1.0	-1.1	-1.2	-0.8	0.3	-1.3
Se content in liver	0.1	0.2	0.6	0.3	0.3	-0.1	0.4	0.4	-0.1	-0.8	0.5
Sr content in liver	0.9	0.9	2.0	0.0	-1.2	0.7	-1.0	-1.2	-0.2	0.7	-1.4
Zn content in liver	0.1	0.1	0.2	0.4	-0.4	-0.1	0.2	0.3	0.2	-0.4	0.2