Hub : Genes

Pelo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000061128 0.05 0.03 4.5e-04 0.02 0.04 0.03 0.03 6.5e-03 2.6e-04 1.4e-03 7.0e-04
2 IL gene expression ENSRNOG00000061128 0.2 0.13 8.9e-03 0.01 0.01 -0.01 -0 2.0e-01 1.4e-01 5.5e-01 3.3e-01
3 PL gene expression ENSRNOG00000061128 0.07 0.05 1.2e-03 0.04 0.03 0.02 0.03 3.8e-04 2.3e-03 8.0e-03 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.41.22.30.41.51.0
BMI without tail2.75.78.22.02.92.2
Body weight2.18.912.02.33.53.1
Epididymis fat weight0.51.21.61.21.30.7
Glucose0.00.00.0-0.1-0.1-0.2
Heart weight0.60.81.00.91.00.8
Left kidney weight0.51.52.11.40.91.2
Right kidney weight0.31.01.71.30.60.9
Tail length2.88.49.93.22.72.8
Length with tail2.07.58.12.82.52.8
Length without tail0.00.00.10.10.10.3
Liver weight, left0.20.30.5-0.1-0.7-0.6
Liver weight, right2.23.75.3-2.3-1.8-1.6
Parametrial fat weight0.00.00.10.10.30.2
Retroperitoneal fat weight0.82.65.01.22.21.2
Intraocular pressure0.60.91.40.5-1.2-1.0
Extensor digitorum longus weight2.18.411.52.23.43.0
Soleus weight9.327.235.35.94.65.1
Tibialis anterior weight3.612.614.83.23.83.5
Tibia length0.10.20.40.70.40.1
Number of licking bursts0.10.10.20.4-0.10.1
Food consumed during 24 hour testing period1.01.21.9-1.4-0.9-0.9
Times rat made contact with spout2.22.53.70.91.71.9
Mean time between licks in bursts0.50.71.31.10.80.4
Mean num. licks in bursts0.40.50.8-0.20.90.8
Std. dev. time between licks in bursts0.80.91.6-0.5-1.3-1.0
Water consumed over 24 hours0.40.50.9-0.6-0.9-0.5
Indifference point 0 sec1.62.64.1-2.0-1.4-1.3
Indifference point AUC0.60.70.90.90.61.0
Indifference point function ln k1.01.41.6-1.2-1.3-1.1
Indifference point function log k1.01.41.6-1.2-1.3-1.1
Delay discounting total patch changes 0 sec1.22.03.0-1.7-1.3-1.2
Delay discounting total patch changes 12 sec0.00.00.0-0.10.10.2
Delay discounting total patch changes 18 sec0.81.01.1-1.1-0.9-1.0
Delay discounting total patch changes 24 sec0.00.00.10.1-0.10.3
Delay discounting total patch changes 6 sec0.10.10.3-0.5-0.10.2
Delay discounting time to switch 0 sec0.10.10.3-0.50.2-0.1
Delay discounting water rate 0 sec0.20.40.70.8-0.6-0.4
Delay discounting water rate 12 sec1.72.53.92.01.31.4
Delay discounting water rate 18 sec0.20.30.60.80.30.4
Delay discounting water rate 24 sec0.00.00.0-0.00.1-0.1
Delay discounting water rate 6 sec0.30.40.60.2-0.8-0.8
Locomotor activity3.55.56.32.32.52.2
Locomotor testing distance1.72.83.81.51.91.5
Locomotor testing rearing0.20.30.60.60.70.1
Light reinforcement 10.10.20.30.6-0.20.4
Light reinforcement 20.60.81.1-0.2-1.1-1.1
Reaction time number correct0.50.80.8-0.9-0.9-0.9
Reaction time mean minus median0.40.50.9-0.2-0.9-0.7
Reaction time mean minus median AUC1.41.82.4-1.0-1.6-1.3
Reaction time num false alarms1.41.92.9-1.7-1.1-1.3
Reaction time num false alarms AUC1.31.82.6-1.6-1.1-1.2
Reaction time trials correct on left0.50.80.8-0.9-0.9-0.9
Reaction time trials on left0.50.80.8-0.8-0.9-0.9
Reaction time mean1.01.31.8-0.6-1.3-1.3
Reaction time mean AUC1.11.52.0-0.8-1.4-1.4
Median of all reaction times1.01.31.8-0.7-1.3-1.3
Reaction time omissions0.50.71.3-0.0-1.2-0.9
Reaction time false alarm rate0.20.30.5-0.7-0.4-0.5
Reaction time premature initiation rate0.70.91.01.00.81.0
Reaction time premature initiations0.20.30.40.50.40.6
Std. dev. reaction times0.70.91.5-0.4-1.2-1.0
Reaction time trials completed0.50.80.8-0.8-0.9-0.9
Reaction time trials AUC0.50.70.8-0.9-0.8-0.8
Social response proportion0.20.20.40.60.5-0.1
Social responses0.20.30.4-0.7-0.5-0.4
Social time0.00.00.1-0.00.1-0.4
Conditioned locomotion0.70.81.01.00.80.9
Cocaine response after cond. corrected0.70.81.60.71.30.5
Cocaine response after cond. not corrected0.10.10.4-0.2-0.1-0.6
Cocaine response before conditioning5.97.29.7-2.3-3.1-2.6
Saline control response0.10.10.2-0.1-0.4-0.0
Condit. Reinf. active minus inactive responses2.32.83.6-1.9-1.6-1.5
Condit. Reinf. active-inactive response ratio1.61.72.9-1.7-1.1-1.0
Condit. Reinf. active responses0.60.81.0-0.9-1.0-0.8
Condit. Reinf. inactive responses0.10.20.30.2-0.6-0.4
Condit. Reinf. lever presses5.67.79.2-3.0-2.8-2.4
Condit. Reinf. lever reinforcers received1.52.02.4-1.4-1.6-1.3
Pavlov. Cond. lever latency7.29.911.23.33.22.9
Pavlov. Cond. magazine entry latency3.54.15.1-2.3-2.0-1.8
Pavlov. Cond. change in total contacts8.311.614.1-3.8-3.3-3.1
Pavlov. Cond. index score6.07.88.8-3.0-2.9-2.5
Pavlov. Cond. latency score5.56.98.1-2.8-2.7-2.4
Pavlov. Cond. lever contacts5.78.09.0-2.9-3.0-2.5
Pavlov. Cond. magazine entry number7.18.89.53.13.02.8
Pavlov. Cond. intertrial magazine entries0.60.81.41.20.80.6
Pavlov. Cond. lever-magazine prob. diff.6.48.39.4-3.1-3.0-2.6
Pavlov. Cond. response bias8.411.613.1-3.5-3.6-3.1
Conditioned reinforcement - actives0.00.00.10.1-0.2-0.1
Conditioned reinforcement - inactives0.40.50.8-0.6-0.9-0.4
Conditioned locomotion0.00.10.10.1-0.3-0.3
Intermittent access intake day 1-15 change0.40.40.8-0.1-0.9-0.6
Intermittent access intake escalation0.50.51.0-0.2-1.0-0.5
Intermittent access intake escalation 20.70.71.4-0.5-1.2-0.7
Intermitt. access day 1 inactive lever presses0.30.30.5-0.7-0.10.6
Intermitt. access day 15 inactive lever presses0.70.81.01.00.80.8
Intermitt. access escalation Index4.64.16.21.52.02.5
Intermittent access day 1 total infusions0.30.30.60.80.50.4
Intermittent access day 15 total infusions0.10.10.40.6-0.2-0.1
Intermittent access terminal intake (last 3 days)0.30.30.70.90.10.3
Intermittent access total infusions0.60.71.11.10.60.7
Intermittent access day 1 locomotion0.00.00.00.10.10.1
Intermittent access day 15 total locomotion0.30.30.7-0.0-0.5-0.8
Intermittent access total locomotion0.00.10.1-0.1-0.2-0.3
Intermittent access standard deviation1.61.72.6-0.3-1.6-1.6
Cocaine induced anxiety0.00.10.1-0.2-0.3-0.1
Post-drug Anxiety0.10.10.1-0.2-0.30.2
Baseline Anxiety0.00.00.00.10.20.0
Lifetime Intake0.20.20.40.60.20.4
Incentive Sensitization - Responses0.80.82.11.40.6-0.0
Incentive Sensitization - Breakpoint0.70.71.81.30.5-0.2
Progressive ratio test 1 active lever presses0.30.31.0-1.00.10.2
Progressive ratio test 1 breakpoint0.30.30.8-0.90.10.3
Progressive ratio test 1 inactive lever presses1.41.52.30.81.31.5
Progressive ratio test 2 active lever presses0.10.10.10.30.2-0.1
Progressive ratio test 2 breakpoint0.10.10.20.30.0-0.5
Progressive ratio test 2 inactive lever presses2.22.53.71.91.51.3
Total sessions with >9 infusions0.10.10.30.30.00.5
Short access day 1 total inactive lever presses4.44.96.51.82.22.6
Short access day 10 total inactive lever presses0.20.20.3-0.5-0.50.4
Short access day 1 total infusions0.30.40.50.60.40.7
Short access day 10 total infusions0.20.20.3-0.4-0.5-0.3
Short access total infusions0.00.00.0-0.0-0.10.1
Short access day 1 locomotion0.10.10.20.4-0.5-0.2
Short access day 10 total locomotion2.83.03.9-1.5-1.7-2.0
Short access total locomotion0.40.50.7-0.6-0.8-0.5
Compulsive drug intake0.10.10.3-0.1-0.3-0.6
One hour access (0.3 mA shock)0.20.20.30.3-0.4-0.6
One hour access (shock baseline)0.00.00.10.3-0.1-0.0
Number of responses in last shaping day1.61.62.7-1.6-1.2-0.8
Context. condit. distance diff. score0.30.30.9-0.90.2-0.0
Locomotion velocity, session 10.20.20.4-0.6-0.3-0.3
Locomotion distance, session 10.81.12.2-0.11.51.0
Locomotion velocity, session 21.21.42.21.50.81.1
Locomotion distance, session 20.60.92.00.11.40.9
Locomotion velocity, session 30.80.91.91.40.21.0
Locomotion distance, session 30.00.00.00.2-0.00.2
Stereotopy head waving bouts, day 35.06.08.62.91.92.4
Stereotopy head waving duration, day 32.53.05.12.31.11.6
Locomotion velocity, session 70.10.10.2-0.2-0.5-0.4
Locomotion distance, session 70.81.01.5-0.7-1.2-1.1
Stereotopy head waving bouts, day 71.01.21.61.10.81.3
Stereotopy head waving duration, day 71.51.92.51.41.11.6
Locomotion velocity, session 80.70.81.2-1.1-0.9-0.7
Locomotion distance, session 80.50.71.9-1.40.60.1
Degree of sensitization distance0.40.40.7-0.5-0.9-0.6
Degree of sensitization stereotypy0.20.20.40.40.40.6
Condit. Reinf. active minus inactive responses1.92.12.2-1.5-1.4-1.4
Condit. Reinf. active-inactive response ratio1.81.92.5-1.1-1.6-1.4
Condit. Reinf. active responses1.82.22.5-1.6-1.4-1.5
Condit. Reinf. inactive responses0.80.91.6-1.3-0.4-0.9
Incentive salience index mean0.60.71.2-1.1-0.4-0.8
Condit. Reinf. lever presses0.20.30.8-0.40.90.1
Time in familiar zone, hab. session 10.20.10.40.10.60.2
Time in novel zone, hab. session 11.01.02.31.50.40.7
Total zone transitions, hab. session 10.91.32.5-1.6-0.7-0.9
Total locomotion distance, hab. session 10.10.20.3-0.40.50.2
Locomotion velocity, hab. session 10.10.20.6-0.70.30.0
Time in familiar zone, hab. session 20.40.40.60.60.60.7
Time in novel zone, hab. session 20.70.70.8-0.8-0.8-0.9
Total zone transitions, hab. session 20.91.22.70.11.60.9
Total locomotion distance, hab. session 22.53.45.91.02.41.8
Locomotion velocity, hab. session 22.73.66.41.12.51.8
Novel to familiar place preference ratio0.50.50.9-0.1-0.8-0.9
Novelty place preference0.30.30.50.2-0.6-0.7
Time in novel zone, NPP test0.30.30.40.3-0.6-0.7
Total zone transitions, NPP test0.20.30.7-0.40.80.4
Total locomotion distance, NPP test0.30.41.0-0.31.00.3
Locomotion velocity, NPP test0.20.30.7-0.40.80.2
Pavlov. Cond. lever latency0.30.30.70.3-0.8-0.5
Pavlov. Cond. magazine entry latency0.20.20.5-0.2-0.4-0.7
Pavlov. Cond. change in total contacts0.00.00.10.3-0.2-0.1
Pavlov. Cond. index score0.00.00.1-0.10.3-0.0
Pavlov. Cond. latency score0.10.10.2-0.30.40.0
Pavlov. Cond. lever contacts0.10.20.3-0.50.4-0.0
Pavlov. Cond. magazine entry number0.10.20.2-0.4-0.4-0.4
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.2-0.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.10.2-0.1
Pavlov. Cond. response bias0.00.00.0-0.10.1-0.1
Bone: apparent density3.04.97.41.52.72.2
Bone surface1.22.13.80.51.91.6
Bone volume0.81.42.60.31.61.3
Bone: connectivity density3.24.96.91.62.62.3
Bone: cortical apparent density6.78.711.0-2.5-3.3-3.0
Bone: cortical area0.10.10.2-0.30.40.0
Bone: cortical porosity1.41.62.11.01.51.2
Bone: cortical porosity0.91.01.60.81.30.9
Bone: cortical thickness0.91.41.7-1.3-1.0-1.3
Bone: cortical thickness2.63.03.8-1.3-2.0-1.9
Bone: cortical tissue density6.48.310.6-2.5-3.3-2.9
Bone: elastic displacement0.30.30.40.50.60.5
Bone: elastic work0.00.00.1-0.00.30.0
Bone: endosteal estimation0.81.83.00.91.71.2
Bone: endosteal perimeter2.04.16.01.42.42.0
Bone: final force0.91.43.4-1.8-0.4-0.9
Bone: final moment0.61.02.7-1.6-0.1-0.7
Bone: marrow area0.92.03.21.01.81.3
Bone: maximum diameter2.54.66.91.62.62.1
Bone: maximum force0.50.92.2-1.5-0.1-0.7
Bone: maximum moment0.30.61.5-1.20.2-0.5
Bone: minimum diameter0.00.10.1-0.20.1-0.4
Bone: periosteal estimation0.30.71.50.31.20.7
Bone: periosteal perimeter1.11.82.90.81.71.4
Bone: post-yield work0.20.30.5-0.7-0.3-0.5
Bone: stiffness0.30.40.9-1.0-0.1-0.6
Bone: tissue strength0.50.50.9-0.80.90.4
Bone: trabecular number1.62.54.20.92.01.6
Bone: trabecular spacing0.60.81.0-0.5-1.0-1.0
Bone: trabecular thickness0.00.00.1-0.30.30.0
Bone: trabecular tissue density1.41.92.7-1.2-1.7-1.2
Breakpoint value in progressive ratio session0.10.10.20.5-0.20.3
Distance traveled before self-admin0.40.50.9-0.21.00.7
Distance traveled after self-admin0.40.41.1-1.1-0.4-0.3
Delta time in closed arm before/after self-admin0.10.10.30.5-0.1-0.4
Delta time in open arm before/after self-admin1.41.33.0-1.7-0.7-0.6
Diff in mean of infusions in LGA sessions0.60.71.2-0.5-1.1-0.8
Extinction: sum of active levers before priming0.60.61.41.20.10.6
Active lever presses in extinction session 60.30.30.60.80.10.3
Delta distance traveled before/after self-admin0.60.71.1-0.7-1.1-0.6
Delta ambulatory time before/after self-admin0.40.50.9-0.7-0.9-0.3
Time in closed arm before self-admin0.10.10.10.4-0.3-0.3
Time in closed arm after self-admin0.90.92.31.50.50.4
Time in open arm before self-admin0.30.30.40.70.20.6
Time in open arm after self-admin0.40.41.2-1.1-0.2-0.2
Sum of active levers in priming session hrs 5-67.27.19.02.91.93.0
Time to tail flick, vehicle, before self-admin0.40.41.2-1.10.00.3
Time to tail flick, vehicle, after self-admin0.60.60.70.90.80.7
Time to tail flick, test, before self-admin1.01.01.21.10.91.0
Time to tail flick, test, after self-admin0.10.10.20.50.2-0.4
Delta time to tail flick, vehicle, before/after SA1.61.63.21.81.10.6
Delta time to tail flick, test, before/after SA0.10.10.20.40.4-0.2
Ambulatory time before self-admin0.70.71.50.11.20.8
Ambulatory time after self-admin0.20.20.5-0.7-0.3-0.3
Total heroin consumption0.10.20.30.5-0.40.3
Area under the delay curve0.60.61.1-0.1-0.8-1.1
Delay disc. indifference point, 0s delay0.20.20.40.2-0.6-0.6
Delay disc. indifference point, 16s delay0.40.50.6-0.8-0.6-0.6
Delay disc. indifference point, 2s delay0.40.51.11.10.40.4
Delay disc. indifference point, 24s delay0.10.10.10.30.20.2
Delay disc. indifference point, 4s delay1.21.32.40.0-1.2-1.5
Delay disc. indifference point, 8s delay0.20.20.40.3-0.1-0.6
Delay discount exponential model param0.50.61.10.10.81.1
Delay discount hyperbolic model param0.40.40.7-0.20.60.8
Fecal boli incidents, locomotor time 11.51.72.80.61.71.4
Change in fecal boli incidents, locomotor task0.00.00.00.1-0.2-0.0
Time >=10cm from walls, locomotor time 11.11.11.50.81.21.2
Bouts of movement, locomotor time 10.30.30.50.60.20.7
Total resting periods, locomotor time 10.20.30.50.50.30.7
Rest time, locomotor task time 10.10.10.2-0.2-0.4-0.1
Distance moved, locomotor task time 10.10.10.1-0.20.30.3
Vertical activity count, locomotor time 10.10.10.20.10.40.5
Time >=10cm from walls, locomotor time 22.42.63.01.71.51.6
Bouts of movement, locomotor time 20.20.20.50.5-0.7-0.0
Total resting periods, locomotor time 20.30.30.80.3-0.9-0.3
Rest time, locomotor task time 21.82.12.2-1.5-1.5-1.4
Distance moved, locomotor task time 20.60.70.80.80.70.9
Vertical activity count, locomotor time 20.50.61.00.50.71.0
Weight adjusted by age0.20.30.60.40.10.8
Seeking ratio, delayed vs. immediate footshock0.91.11.91.41.00.7
Locomotion in novel chamber0.10.10.20.0-0.5-0.2
Locomotion in novel chamber post-restriction0.60.70.8-0.9-0.7-0.9
Progressive ratio1.92.22.51.51.61.4
Food seeking constrained by brief footshock1.41.72.01.21.41.3
Seeking ratio, punishment vs. effort0.70.80.9-1.0-0.9-0.8
Run reversals in cocaine runway, females1.41.41.8-1.3-1.1-1.1
Run reversals in cocaine runway, males0.10.10.20.5-0.0-0.3
Latency to leave start box in cocaine runway0.10.10.30.20.3-0.5
Latency to leave start box in cocaine runway, F0.40.40.7-0.7-0.3-0.8
Latency to leave start box in cocaine runway, M1.00.91.71.30.90.5
Cd content in liver6.16.77.9-2.6-2.3-2.8
Co content in liver0.30.40.7-0.8-0.2-0.7
Cu content in liver0.40.50.9-0.2-0.9-0.7
Fe content in liver0.30.30.50.70.40.5
K content in liver0.40.41.0-1.0-0.4-0.3
Mg content in liver2.02.12.8-1.7-1.4-1.3
Mn content in liver0.91.11.91.40.80.8
Na content in liver0.10.10.2-0.5-0.1-0.0
Rb content in liver1.21.52.2-0.9-1.5-1.2
Se content in liver0.70.81.0-0.9-0.8-1.0
Sr content in liver1.31.21.31.01.11.1
Zn content in liver4.44.84.8-2.2-2.2-2.2