AC107531.3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA ENSRNOT00000015108 0.1 0.07 1.9e-09 0.05 0.05 0.05 0.05 2.4e-06 4.2e-06 3.3e-06 3.1e-06
2 Liver alternative polyA ENSRNOT00000107542 0.09 0.06 8.2e-09 0.05 0.04 0.04 0.04 6.4e-06 1.3e-05 9.3e-06 1.3e-05
3 Liver alternative TSS ENSRNOT00000107542 0.16 0.1 7.2e-16 0.12 0.13 0.12 0.13 1.3e-13 1.2e-14 1.1e-13 8.2e-14
4 Liver alternative TSS ENSRNOT00000117195 0.16 0.1 7.2e-16 0.13 0.13 0.12 0.13 4.3e-14 1.3e-14 1.1e-13 8.0e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.41.22.0-0.80.81.4-1.4
BMI without tail1.12.43.3-1.21.21.8-1.8
Body weight1.56.27.0-2.32.32.6-2.6
Epididymis fat weight1.43.23.82.0-2.0-1.61.6
Glucose2.03.13.21.8-1.8-1.71.7
Heart weight0.60.91.1-1.01.00.8-0.8
Left kidney weight9.828.129.6-5.45.45.1-5.2
Right kidney weight5.816.617.0-4.14.14.0-4.0
Tail length0.72.22.4-1.61.61.4-1.4
Length with tail1.24.55.2-2.32.31.9-1.9
Length without tail0.71.51.9-1.41.41.1-1.1
Liver weight, left11.118.019.9-4.04.04.5-4.4
Liver weight, right2.64.45.1-1.91.92.2-2.2
Parametrial fat weight1.73.44.72.2-2.2-1.41.5
Retroperitoneal fat weight1.96.28.62.9-2.9-1.92.0
Intraocular pressure0.10.10.10.2-0.2-0.40.4
Extensor digitorum longus weight1.66.46.7-2.52.52.6-2.6
Soleus weight0.20.70.8-0.80.80.9-0.9
Tibialis anterior weight1.65.47.2-1.91.92.7-2.6
Tibia length3.59.911.7-3.43.42.8-2.9
Number of licking bursts2.02.32.6-1.41.41.6-1.6
Food consumed during 24 hour testing period2.22.63.01.5-1.5-1.71.7
Times rat made contact with spout0.40.50.50.7-0.7-0.70.7
Mean time between licks in bursts0.00.00.00.2-0.20.0-0.0
Mean num. licks in bursts3.13.74.11.8-1.8-2.02.0
Std. dev. time between licks in bursts0.91.11.1-1.11.11.1-1.1
Water consumed over 24 hours0.10.10.20.2-0.2-0.40.4
Indifference point 0 sec0.10.10.10.4-0.4-0.20.2
Indifference point AUC2.73.23.6-1.71.71.9-1.9
Indifference point function ln k0.91.32.20.7-0.7-1.51.4
Indifference point function log k0.91.32.20.7-0.7-1.51.4
Delay discounting total patch changes 0 sec0.00.10.10.3-0.3-0.10.1
Delay discounting total patch changes 12 sec0.81.11.4-0.90.91.2-1.2
Delay discounting total patch changes 18 sec1.11.51.8-1.11.11.3-1.3
Delay discounting total patch changes 24 sec1.41.71.9-1.31.31.4-1.4
Delay discounting total patch changes 6 sec0.30.40.7-0.40.40.8-0.8
Delay discounting time to switch 0 sec4.36.58.12.9-2.9-2.22.3
Delay discounting water rate 0 sec2.84.55.2-2.32.31.9-2.0
Delay discounting water rate 12 sec0.30.40.8-0.90.90.3-0.3
Delay discounting water rate 18 sec0.00.00.0-0.20.2-0.00.0
Delay discounting water rate 24 sec0.00.00.0-0.20.2-0.20.1
Delay discounting water rate 6 sec5.47.89.6-3.13.12.4-2.5
Locomotor activity1.01.61.9-1.11.11.4-1.3
Locomotor testing distance0.40.70.8-0.80.80.9-0.9
Locomotor testing rearing6.29.710.0-3.23.23.1-3.1
Light reinforcement 10.61.11.3-1.11.11.0-1.0
Light reinforcement 20.50.70.9-0.70.71.0-0.9
Reaction time number correct2.02.83.1-1.61.61.8-1.8
Reaction time mean minus median0.50.60.70.7-0.7-0.80.8
Reaction time mean minus median AUC0.00.00.00.0-0.0-0.20.2
Reaction time num false alarms4.76.57.3-2.42.42.7-2.7
Reaction time num false alarms AUC3.75.25.9-2.12.12.4-2.4
Reaction time trials correct on left2.02.83.1-1.61.61.8-1.8
Reaction time trials on left2.02.93.2-1.61.61.8-1.8
Reaction time mean1.42.02.21.3-1.3-1.51.5
Reaction time mean AUC1.62.12.21.4-1.4-1.51.5
Median of all reaction times1.31.82.01.3-1.3-1.41.4
Reaction time omissions0.10.10.2-0.30.30.4-0.4
Reaction time false alarm rate0.50.70.8-0.70.70.9-0.9
Reaction time premature initiation rate2.33.13.21.7-1.7-1.81.8
Reaction time premature initiations0.60.80.90.9-0.9-0.90.9
Std. dev. reaction times0.71.01.10.9-0.9-1.11.1
Reaction time trials completed2.02.93.2-1.61.61.8-1.8
Reaction time trials AUC2.43.53.8-1.81.82.0-2.0
Social response proportion0.70.80.9-0.80.81.0-1.0
Social responses3.14.04.3-2.12.11.9-1.9
Social time0.20.30.6-0.80.80.1-0.2
Conditioned locomotion0.10.10.1-0.20.20.3-0.3
Cocaine response after cond. corrected0.10.10.20.4-0.4-0.10.2
Cocaine response after cond. not corrected0.50.50.6-0.70.70.7-0.7
Cocaine response before conditioning5.16.37.6-2.82.82.2-2.3
Saline control response1.41.92.1-1.51.51.3-1.3
Condit. Reinf. active minus inactive responses0.50.71.1-1.11.10.4-0.5
Condit. Reinf. active-inactive response ratio0.70.71.1-1.11.10.5-0.5
Condit. Reinf. active responses0.50.61.1-1.01.00.4-0.5
Condit. Reinf. inactive responses0.00.00.10.1-0.1-0.30.2
Condit. Reinf. lever presses0.81.11.2-1.11.11.0-1.0
Condit. Reinf. lever reinforcers received0.81.11.7-1.31.30.6-0.7
Pavlov. Cond. lever latency0.00.00.10.1-0.1-0.30.3
Pavlov. Cond. magazine entry latency0.10.10.10.4-0.4-0.10.1
Pavlov. Cond. change in total contacts0.00.10.10.1-0.1-0.40.3
Pavlov. Cond. index score0.00.00.0-0.10.10.2-0.2
Pavlov. Cond. latency score0.00.10.10.3-0.3-0.10.1
Pavlov. Cond. lever contacts0.30.50.5-0.60.60.7-0.7
Pavlov. Cond. magazine entry number0.30.30.3-0.60.60.5-0.5
Pavlov. Cond. intertrial magazine entries0.60.81.3-1.11.10.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.30.30.4-0.4
Pavlov. Cond. response bias0.30.40.5-0.70.70.6-0.6
Conditioned reinforcement - actives0.70.61.0-0.60.61.0-1.0
Conditioned reinforcement - inactives2.12.42.8-1.71.71.4-1.4
Conditioned locomotion0.40.50.7-0.50.50.9-0.8
Intermittent access intake day 1-15 change0.20.20.2-0.40.40.4-0.4
Intermittent access intake escalation0.00.00.0-0.20.20.2-0.2
Intermittent access intake escalation 20.20.20.2-0.50.50.3-0.3
Intermitt. access day 1 inactive lever presses0.80.80.9-0.90.90.9-0.9
Intermitt. access day 15 inactive lever presses3.13.43.9-1.71.72.0-2.0
Intermitt. access escalation Index0.10.10.20.5-0.5-0.10.2
Intermittent access day 1 total infusions0.91.01.1-1.01.01.0-1.0
Intermittent access day 15 total infusions0.10.10.2-0.20.20.4-0.4
Intermittent access terminal intake (last 3 days)0.10.10.2-0.30.30.4-0.4
Intermittent access total infusions0.50.50.6-0.70.70.8-0.8
Intermittent access day 1 locomotion0.20.20.20.4-0.4-0.50.5
Intermittent access day 15 total locomotion0.30.30.40.6-0.6-0.50.5
Intermittent access total locomotion0.00.00.0-0.10.10.1-0.1
Intermittent access standard deviation0.60.61.0-0.60.61.0-1.0
Cocaine induced anxiety0.60.61.20.3-0.3-1.11.1
Post-drug Anxiety0.10.10.10.1-0.1-0.30.3
Baseline Anxiety0.10.10.20.4-0.40.1-0.1
Lifetime Intake0.30.40.5-0.50.50.7-0.7
Incentive Sensitization - Responses0.30.30.4-0.50.50.6-0.6
Incentive Sensitization - Breakpoint0.20.20.3-0.40.40.6-0.6
Progressive ratio test 1 active lever presses0.60.60.8-0.90.90.7-0.7
Progressive ratio test 1 breakpoint0.60.60.8-0.90.90.6-0.7
Progressive ratio test 1 inactive lever presses4.34.65.3-2.32.32.0-2.0
Progressive ratio test 2 active lever presses0.20.20.4-0.30.30.6-0.6
Progressive ratio test 2 breakpoint0.30.30.4-0.40.40.6-0.6
Progressive ratio test 2 inactive lever presses1.41.61.6-1.31.31.3-1.3
Total sessions with >9 infusions2.62.93.1-1.71.71.7-1.7
Short access day 1 total inactive lever presses1.51.61.7-1.31.31.3-1.3
Short access day 10 total inactive lever presses0.20.20.30.4-0.4-0.60.6
Short access day 1 total infusions0.30.40.4-0.60.60.6-0.6
Short access day 10 total infusions1.71.82.2-1.21.21.5-1.5
Short access total infusions0.10.10.1-0.10.10.4-0.4
Short access day 1 locomotion0.40.40.4-0.70.70.6-0.6
Short access day 10 total locomotion0.80.91.00.9-0.9-1.01.0
Short access total locomotion0.20.20.30.5-0.5-0.40.4
Compulsive drug intake0.00.00.0-0.20.2-0.10.0
One hour access (0.3 mA shock)0.00.00.00.0-0.0-0.10.1
One hour access (shock baseline)0.60.71.0-0.70.71.0-1.0
Number of responses in last shaping day0.30.30.5-0.40.40.7-0.7
Context. condit. distance diff. score0.10.20.2-0.40.40.4-0.4
Locomotion velocity, session 10.20.20.30.4-0.4-0.60.6
Locomotion distance, session 10.30.40.7-0.80.80.2-0.3
Locomotion velocity, session 21.31.61.7-1.31.31.2-1.2
Locomotion distance, session 22.12.93.6-1.91.91.5-1.5
Locomotion velocity, session 30.10.20.2-0.40.40.4-0.4
Locomotion distance, session 30.10.10.1-0.40.4-0.0-0.0
Stereotopy head waving bouts, day 30.00.00.00.1-0.10.2-0.2
Stereotopy head waving duration, day 30.10.10.10.3-0.3-0.10.2
Locomotion velocity, session 71.01.11.30.9-0.9-1.11.1
Locomotion distance, session 70.00.10.10.2-0.2-0.30.3
Stereotopy head waving bouts, day 70.30.40.4-0.60.60.6-0.6
Stereotopy head waving duration, day 70.40.50.5-0.70.70.7-0.7
Locomotion velocity, session 80.00.00.00.1-0.1-0.10.1
Locomotion distance, session 80.60.91.2-1.11.10.8-0.8
Degree of sensitization distance0.10.10.10.4-0.4-0.20.2
Degree of sensitization stereotypy1.61.71.9-1.41.41.3-1.3
Condit. Reinf. active minus inactive responses0.40.40.6-0.50.50.8-0.8
Condit. Reinf. active-inactive response ratio0.40.40.6-0.40.40.8-0.8
Condit. Reinf. active responses0.30.40.4-0.60.60.7-0.7
Condit. Reinf. inactive responses0.00.00.0-0.20.2-0.20.1
Incentive salience index mean0.60.70.8-0.80.80.9-0.9
Condit. Reinf. lever presses0.40.50.5-0.70.70.7-0.7
Time in familiar zone, hab. session 10.40.40.6-0.80.80.3-0.4
Time in novel zone, hab. session 10.30.30.5-0.40.40.7-0.7
Total zone transitions, hab. session 10.40.60.9-1.01.00.5-0.5
Total locomotion distance, hab. session 10.10.10.20.2-0.2-0.50.4
Locomotion velocity, hab. session 10.50.81.10.7-0.7-1.01.0
Time in familiar zone, hab. session 20.10.10.1-0.30.30.0-0.1
Time in novel zone, hab. session 20.00.00.1-0.00.00.3-0.3
Total zone transitions, hab. session 21.51.92.6-1.61.61.1-1.1
Total locomotion distance, hab. session 20.20.30.40.4-0.4-0.60.6
Locomotion velocity, hab. session 20.10.10.20.3-0.3-0.40.4
Novel to familiar place preference ratio0.70.70.8-0.80.80.9-0.9
Novelty place preference0.70.70.7-0.80.80.8-0.8
Time in novel zone, NPP test0.70.70.8-0.90.90.9-0.9
Total zone transitions, NPP test0.50.70.8-0.90.90.8-0.8
Total locomotion distance, NPP test0.10.20.2-0.40.40.4-0.4
Locomotion velocity, NPP test0.20.30.3-0.50.50.5-0.5
Pavlov. Cond. lever latency0.60.80.90.8-0.8-0.90.9
Pavlov. Cond. magazine entry latency0.60.81.0-0.80.81.0-1.0
Pavlov. Cond. change in total contacts0.10.10.10.3-0.3-0.20.2
Pavlov. Cond. index score0.91.21.4-1.01.01.2-1.2
Pavlov. Cond. latency score0.40.50.6-0.60.60.8-0.8
Pavlov. Cond. lever contacts0.91.11.2-1.01.01.1-1.1
Pavlov. Cond. magazine entry number0.70.80.90.9-0.9-1.00.9
Pavlov. Cond. intertrial magazine entries0.20.30.40.5-0.5-0.60.6
Pavlov. Cond. lever-magazine prob. diff.1.11.41.7-1.11.11.3-1.3
Pavlov. Cond. response bias2.73.33.6-1.71.71.9-1.9
Bone: apparent density0.20.30.40.4-0.4-0.60.6
Bone surface0.71.21.8-1.31.30.7-0.8
Bone volume0.20.40.7-0.90.90.3-0.3
Bone: connectivity density0.00.10.10.1-0.1-0.30.3
Bone: cortical apparent density0.20.30.40.6-0.6-0.40.4
Bone: cortical area0.91.41.6-1.31.31.0-1.1
Bone: cortical porosity0.10.10.20.5-0.5-0.20.2
Bone: cortical porosity0.10.10.2-0.10.10.4-0.4
Bone: cortical thickness0.10.20.30.5-0.5-0.30.3
Bone: cortical thickness0.30.30.3-0.60.60.5-0.6
Bone: cortical tissue density0.20.30.40.6-0.6-0.40.4
Bone: elastic displacement3.54.04.22.1-2.1-1.91.9
Bone: elastic work0.10.10.20.3-0.3-0.50.4
Bone: endosteal estimation0.71.62.4-1.61.60.8-0.9
Bone: endosteal perimeter0.51.11.6-1.31.30.7-0.8
Bone: final force1.52.53.1-1.81.81.4-1.4
Bone: final moment1.93.13.9-2.02.01.5-1.6
Bone: marrow area0.81.82.7-1.61.60.9-1.0
Bone: maximum diameter3.36.06.4-2.52.52.3-2.4
Bone: maximum force1.01.82.3-1.51.51.1-1.2
Bone: maximum moment1.22.12.8-1.71.71.2-1.2
Bone: minimum diameter1.42.73.8-1.91.91.2-1.3
Bone: periosteal estimation1.22.53.3-1.81.81.2-1.3
Bone: periosteal perimeter1.22.02.7-1.61.61.1-1.1
Bone: post-yield work0.20.30.5-0.70.70.3-0.4
Bone: stiffness2.54.04.5-2.12.11.8-1.9
Bone: tissue strength0.10.10.10.2-0.2-0.30.3
Bone: trabecular number0.20.40.50.5-0.5-0.70.7
Bone: trabecular spacing0.10.20.2-0.30.30.5-0.5
Bone: trabecular thickness0.10.20.2-0.40.40.4-0.4
Bone: trabecular tissue density0.10.10.20.5-0.50.1-0.1
Breakpoint value in progressive ratio session5.35.96.92.6-2.6-2.22.3
Distance traveled before self-admin0.30.30.5-0.70.70.4-0.4
Distance traveled after self-admin0.30.30.50.4-0.4-0.70.7
Delta time in closed arm before/after self-admin0.10.10.1-0.20.20.3-0.4
Delta time in open arm before/after self-admin0.30.30.5-0.70.70.4-0.4
Diff in mean of infusions in LGA sessions1.11.21.41.0-1.0-1.21.2
Extinction: sum of active levers before priming0.40.40.60.6-0.6-0.80.7
Active lever presses in extinction session 60.70.71.1-0.50.51.0-1.0
Delta distance traveled before/after self-admin0.70.70.70.9-0.9-0.80.8
Delta ambulatory time before/after self-admin0.91.01.11.0-1.0-0.90.9
Time in closed arm before self-admin0.10.10.2-0.40.40.4-0.4
Time in closed arm after self-admin0.00.00.00.0-0.00.1-0.1
Time in open arm before self-admin0.00.00.00.2-0.2-0.20.2
Time in open arm after self-admin0.00.00.1-0.20.20.0-0.0
Sum of active levers in priming session hrs 5-62.92.93.11.8-1.8-1.61.6
Time to tail flick, vehicle, before self-admin0.00.00.1-0.20.2-0.10.1
Time to tail flick, vehicle, after self-admin0.20.20.30.5-0.5-0.30.3
Time to tail flick, test, before self-admin0.60.61.10.4-0.4-1.01.0
Time to tail flick, test, after self-admin0.00.00.0-0.00.00.1-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.10.3-0.30.1-0.1
Delta time to tail flick, test, before/after SA0.10.10.2-0.10.10.5-0.4
Ambulatory time before self-admin0.30.30.5-0.70.70.2-0.3
Ambulatory time after self-admin0.50.61.00.5-0.5-1.00.9
Total heroin consumption0.20.20.40.6-0.6-0.30.3
Area under the delay curve1.01.11.41.2-1.2-0.90.9
Delay disc. indifference point, 0s delay0.00.00.00.1-0.1-0.20.2
Delay disc. indifference point, 16s delay1.31.31.61.3-1.3-1.01.0
Delay disc. indifference point, 2s delay0.60.70.80.9-0.9-0.70.7
Delay disc. indifference point, 24s delay0.20.10.30.5-0.5-0.10.1
Delay disc. indifference point, 4s delay0.20.20.2-0.40.40.4-0.4
Delay disc. indifference point, 8s delay1.61.61.91.4-1.4-1.21.2
Delay discount exponential model param0.80.81.1-1.01.00.7-0.8
Delay discount hyperbolic model param0.40.50.6-0.80.80.5-0.6
Fecal boli incidents, locomotor time 10.00.00.00.0-0.0-0.20.2
Change in fecal boli incidents, locomotor task1.41.41.71.3-1.3-1.01.0
Time >=10cm from walls, locomotor time 10.40.40.50.7-0.7-0.60.6
Bouts of movement, locomotor time 10.50.50.90.5-0.5-0.90.9
Total resting periods, locomotor time 11.51.72.21.1-1.1-1.51.5
Rest time, locomotor task time 10.00.00.1-0.30.3-0.20.2
Distance moved, locomotor task time 10.10.10.10.1-0.10.3-0.3
Vertical activity count, locomotor time 10.10.10.20.4-0.4-0.10.2
Time >=10cm from walls, locomotor time 20.10.10.10.3-0.3-0.20.2
Bouts of movement, locomotor time 21.71.81.91.4-1.4-1.41.4
Total resting periods, locomotor time 22.02.22.31.4-1.4-1.51.5
Rest time, locomotor task time 21.11.31.80.9-0.9-1.31.3
Distance moved, locomotor task time 21.51.82.4-1.11.11.5-1.5
Vertical activity count, locomotor time 20.91.01.2-0.90.91.1-1.1
Weight adjusted by age1.51.72.1-1.51.51.1-1.1
Seeking ratio, delayed vs. immediate footshock0.81.01.30.8-0.8-1.11.1
Locomotion in novel chamber4.75.86.12.4-2.4-2.52.5
Locomotion in novel chamber post-restriction1.11.41.51.1-1.1-1.21.2
Progressive ratio0.00.00.00.1-0.1-0.20.2
Food seeking constrained by brief footshock1.61.92.61.1-1.1-1.61.6
Seeking ratio, punishment vs. effort0.40.50.60.6-0.6-0.80.8
Run reversals in cocaine runway, females2.52.52.61.6-1.6-1.51.6
Run reversals in cocaine runway, males1.31.31.4-1.11.11.2-1.2
Latency to leave start box in cocaine runway0.30.30.40.5-0.5-0.60.6
Latency to leave start box in cocaine runway, F0.10.10.20.3-0.3-0.40.4
Latency to leave start box in cocaine runway, M0.30.30.3-0.50.50.5-0.5
Cd content in liver0.00.00.0-0.10.1-0.10.1
Co content in liver0.91.11.21.0-1.0-1.11.1
Cu content in liver0.91.01.2-1.11.10.9-1.0
Fe content in liver0.50.50.6-0.70.70.7-0.7
K content in liver2.22.22.2-1.51.51.5-1.5
Mg content in liver1.21.31.5-1.01.01.2-1.2
Mn content in liver0.80.91.1-0.80.81.1-1.0
Na content in liver0.10.10.20.4-0.4-0.20.2
Rb content in liver0.60.70.8-0.90.90.8-0.8
Se content in liver3.54.25.4-1.81.82.3-2.3
Sr content in liver0.50.50.70.8-0.8-0.40.5
Zn content in liver0.40.40.6-0.50.50.7-0.7