Hub : Genes

ENSRNOG00000059160

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	intron excision ratio	chr5:157424954:157445348	0.13	0.09	1.4e-05	0.03	0.04	0.03	0.03	2.1e-04	4.0e-05	4.2e-04	4.4e-04
2	BLA	intron excision ratio	chr5:157445440:157447247	0.09	0.1	1.2e-03	0.03	0.04	0.01	0.02	1.4e-02	4.8e-03	5.6e-02	2.3e-02
3	Brain	intron excision ratio	chr5:157445440:157447247	0.11	0.08	3.4e-08	0.09	0.09	0.08	0.08	1.4e-08	2.1e-08	4.0e-08	3.4e-08
4	Liver	intron excision ratio	chr5:157445440:157447167	0.03	0.03	3.9e-03	0.03	0.01	0.02	0.02	7.7e-04	2.0e-02	5.6e-03	2.5e-03
5	Liver	intron excision ratio	chr5:157445440:157447247	0.03	0.02	3.3e-04	0.02	0.02	0.02	0.02	2.0e-03	1.2e-03	1.2e-03	1.4e-03
6	NAcc	intron excision ratio	chr5:157445440:157447247	0.03	0.04	5.9e-03	0.02	0.03	0.04	0.03	6.0e-03	3.8e-03	6.7e-04	4.2e-03
7	PL	gene expression	ENSRNOG00000059160	0.04	0.04	2.3e-03	0.03	0.03	0.02	0.02	4.3e-03	1.9e-03	6.5e-03	5.4e-03
8	PL	intron excision ratio	chr5:157445440:157447247	0.03	0.03	8.8e-03	0.01	0.02	0.02	0.01	3.2e-02	1.4e-02	1.8e-02	2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
BMI with tail	0.1	0.4	1.1	-1.1	-0.3	-0.8	-0.4	0.0	0.9	0.5	-0.4
BMI without tail	3.4	7.1	8.8	-2.3	-2.7	-3.0	-2.9	-2.6	-2.3	2.7	-2.7
Body weight	0.9	3.6	6.4	-2.5	-1.8	-2.2	-1.8	-1.4	0.9	2.1	-2.0
Epididymis fat weight	1.4	3.2	5.5	-2.3	-1.7	-2.2	-1.7	-1.3	0.8	2.0	-1.9
Glucose	0.1	0.2	1.2	0.2	0.3	0.2	0.1	0.3	-1.1	-0.3	0.3
Heart weight	3.6	5.2	8.0	2.1	2.3	2.1	1.9	2.0	2.8	-2.4	2.4
Left kidney weight	0.2	0.6	2.0	-0.2	0.6	0.7	0.9	0.9	1.4	-0.4	0.5
Right kidney weight	0.3	0.9	4.8	-0.2	0.7	0.6	0.8	0.9	2.2	-0.4	0.5
Tail length	2.8	8.3	9.2	-2.6	-3.0	-2.8	-3.0	-2.9	-2.8	3.0	-3.0
Length with tail	0.9	3.4	5.2	-2.3	-1.9	-1.7	-1.9	-1.6	0.1	2.2	-2.1
Length without tail	1.4	3.0	9.5	0.2	1.6	1.5	1.7	1.9	3.1	-1.2	1.4
Liver weight, left	0.0	0.0	0.3	0.2	0.0	-0.1	-0.0	-0.0	0.5	-0.1	0.0
Liver weight, right	0.2	0.3	1.3	-1.1	-0.3	-0.3	0.0	-0.2	0.4	0.6	-0.5
Parametrial fat weight	0.6	1.3	3.1	-1.8	-0.8	-0.7	-0.9	-0.3	1.6	1.2	-1.0
Retroperitoneal fat weight	0.2	0.7	2.6	-1.6	-0.1	-0.7	0.0	0.4	1.3	0.6	-0.4
Intraocular pressure	0.8	1.1	1.5	-1.1	-1.1	-1.2	-1.2	-1.0	0.2	1.1	-1.1
Extensor digitorum longus weight	0.0	0.1	0.4	-0.1	-0.2	-0.1	-0.4	-0.0	0.7	0.1	-0.2
Soleus weight	0.3	0.9	1.6	-0.2	-1.1	-0.8	-1.3	-1.2	-0.6	0.9	-1.0
Tibialis anterior weight	0.1	0.4	1.0	-0.6	-0.6	-0.8	-1.0	-0.6	0.2	0.6	-0.6
Tibia length	0.6	1.7	3.0	-1.7	-1.1	-1.5	-1.5	-1.0	-0.3	1.4	-1.3
Number of licking bursts	6.0	7.1	9.5	1.8	3.1	2.6	2.6	3.0	2.2	-2.8	2.9
Food consumed during 24 hour testing period	3.6	4.3	5.4	-2.2	-2.2	-2.2	-2.2	-2.0	-1.1	2.3	-2.3
Times rat made contact with spout	0.5	0.5	1.4	0.1	-0.7	-0.8	-0.8	-0.8	-1.2	0.4	-0.5
Mean time between licks in bursts	0.2	0.3	0.5	0.5	0.7	0.5	0.5	0.7	0.3	-0.7	0.7
Mean num. licks in bursts	6.7	8.1	10.7	-1.7	-3.3	-2.8	-2.8	-3.3	-2.6	2.9	-3.0
Std. dev. time between licks in bursts	5.0	6.0	7.8	2.7	2.6	2.4	2.4	2.3	1.1	-2.8	2.7
Water consumed over 24 hours	2.4	2.9	3.9	-1.2	-1.8	-2.0	-2.0	-1.8	-1.3	1.7	-1.7
Indifference point 0 sec	0.8	1.3	7.6	0.3	-0.7	-0.5	-0.7	-0.8	-2.8	0.4	-0.5
Indifference point AUC	0.7	0.8	1.6	-0.6	0.9	0.5	1.2	1.3	1.2	-0.4	0.6
Indifference point function ln k	2.3	3.3	5.8	-0.4	-2.1	-1.6	-2.2	-2.4	-1.5	1.7	-1.9
Indifference point function log k	2.3	3.3	5.8	-0.4	-2.1	-1.6	-2.2	-2.4	-1.5	1.7	-1.9
Delay discounting total patch changes 0 sec	0.8	1.3	7.1	0.2	-0.9	-0.7	-0.8	-0.9	-2.7	0.6	-0.7
Delay discounting total patch changes 12 sec	0.2	0.2	1.3	0.1	0.3	0.1	0.4	0.3	-1.1	-0.2	0.3
Delay discounting total patch changes 18 sec	0.5	0.7	1.5	0.7	0.7	0.5	0.9	1.0	-1.2	-0.8	0.8
Delay discounting total patch changes 24 sec	0.1	0.1	0.3	-0.1	0.2	0.0	0.5	0.5	0.0	-0.1	0.1
Delay discounting total patch changes 6 sec	0.4	0.6	1.4	-0.6	-0.7	-1.0	-0.6	-0.7	-1.2	0.7	-0.7
Delay discounting time to switch 0 sec	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.2	-0.1	-0.2	-0.1	0.0
Delay discounting water rate 0 sec	0.0	0.0	0.0	0.2	-0.2	0.0	-0.0	-0.0	0.2	0.1	-0.1
Delay discounting water rate 12 sec	0.8	1.2	2.7	1.6	0.8	1.1	0.9	0.7	1.1	-1.1	1.0
Delay discounting water rate 18 sec	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.1	0.1	0.1	-0.1	0.0
Delay discounting water rate 24 sec	0.2	0.3	0.7	-0.6	-0.3	-0.7	-0.3	-0.1	0.8	0.4	-0.4
Delay discounting water rate 6 sec	0.5	0.7	2.5	0.7	0.7	0.8	0.6	0.6	1.6	-0.7	0.7
Locomotor activity	0.8	1.2	1.8	0.7	1.2	1.3	1.2	1.3	0.5	-1.1	1.2
Locomotor testing distance	2.4	3.9	6.0	1.9	1.9	2.4	2.2	2.0	1.1	-2.0	2.0
Locomotor testing rearing	0.3	0.4	1.5	1.2	0.3	0.7	0.5	0.2	-0.3	-0.7	0.5
Light reinforcement 1	0.4	0.7	1.1	1.1	0.7	0.8	0.6	0.5	-1.0	-0.9	0.8
Light reinforcement 2	0.5	0.7	1.7	0.3	0.8	0.8	0.8	0.8	1.3	-0.6	0.7
Reaction time number correct	0.0	0.1	0.2	0.2	-0.1	-0.3	-0.4	-0.2	0.3	0.0	-0.1
Reaction time mean minus median	1.7	2.2	2.9	-1.5	-1.7	-1.4	-1.1	-1.6	-1.0	1.7	-1.7
Reaction time mean minus median AUC	0.3	0.4	0.7	-0.8	-0.7	-0.5	-0.2	-0.5	0.1	0.8	-0.7
Reaction time num false alarms	0.6	0.9	1.3	-0.8	-1.2	-0.6	-0.6	-0.9	-1.0	1.1	-1.1
Reaction time num false alarms AUC	1.2	1.7	2.6	-1.2	-1.6	-0.8	-0.7	-1.2	-1.4	1.6	-1.6
Reaction time trials correct on left	0.0	0.1	0.2	0.2	-0.1	-0.3	-0.4	-0.2	0.3	0.0	-0.1
Reaction time trials on left	0.1	0.1	0.3	0.0	-0.2	-0.4	-0.5	-0.2	0.4	0.1	-0.2
Reaction time mean	0.4	0.5	2.3	-0.4	-0.6	-0.5	-0.2	-0.6	-1.5	0.6	-0.6
Reaction time mean AUC	0.3	0.4	1.6	-0.4	-0.5	-0.5	-0.1	-0.4	-1.3	0.5	-0.5
Median of all reaction times	0.2	0.2	1.7	-0.0	-0.2	-0.2	0.2	-0.1	-1.3	0.1	-0.2
Reaction time omissions	2.7	3.7	6.7	-2.6	-2.0	-1.9	-1.5	-1.6	0.4	2.3	-2.2
Reaction time false alarm rate	0.9	1.2	1.9	-1.2	-1.4	-0.6	-0.5	-0.9	-1.2	1.4	-1.3
Reaction time premature initiation rate	0.0	0.1	0.3	0.6	0.1	0.0	-0.3	-0.1	-0.1	-0.2	0.2
Reaction time premature initiations	0.1	0.1	0.3	0.5	-0.1	-0.2	-0.5	-0.3	0.2	-0.1	0.0
Std. dev. reaction times	1.0	1.4	2.3	-0.9	-1.3	-1.0	-0.6	-1.2	-1.5	1.3	-1.3
Reaction time trials completed	0.1	0.1	0.3	0.0	-0.2	-0.4	-0.5	-0.2	0.4	0.1	-0.2
Reaction time trials AUC	0.1	0.1	0.4	0.1	-0.3	-0.4	-0.6	-0.4	-0.0	0.2	-0.3
Social response proportion	0.7	0.8	5.6	-0.5	0.1	0.3	0.3	0.5	2.4	0.1	-0.0
Social responses	0.6	0.8	2.5	0.5	0.8	1.0	0.7	0.8	1.6	-0.7	0.8
Social time	0.1	0.2	0.7	0.2	-0.3	0.1	-0.3	-0.5	0.8	0.2	-0.2
Conditioned locomotion	2.1	2.5	2.9	1.7	1.5	1.7	1.6	1.4	1.6	-1.7	1.6
Cocaine response after cond. corrected	0.9	1.0	2.7	-1.6	-1.1	-0.6	-0.6	-0.5	-0.1	1.4	-1.2
Cocaine response after cond. not corrected	1.5	1.7	3.1	-1.8	-1.5	-0.9	-0.9	-0.8	-0.7	1.7	-1.6
Cocaine response before conditioning	0.3	0.4	0.8	0.1	-0.6	-0.8	-0.8	-0.5	-0.9	0.4	-0.5
Saline control response	0.2	0.2	0.8	0.1	-0.4	-0.4	-0.4	-0.5	-0.9	0.2	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.4	-0.5	-0.3	0.0	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.6	0.0	-0.4	-0.3	-0.2	-0.6	-0.2	0.1
Condit. Reinf. active responses	0.1	0.2	0.8	0.9	0.2	0.0	0.0	-0.1	-0.4	-0.4	0.3
Condit. Reinf. inactive responses	0.0	0.1	0.3	0.5	-0.0	0.1	0.0	-0.2	-0.3	-0.2	0.1
Condit. Reinf. lever presses	0.4	0.6	1.3	1.2	0.9	0.5	0.5	0.4	-0.1	-1.0	1.0
Condit. Reinf. lever reinforcers received	0.1	0.2	0.6	0.8	0.4	0.2	0.2	0.0	0.1	-0.6	0.5
Pavlov. Cond. lever latency	0.8	1.1	1.9	-1.4	-1.2	-0.8	-0.8	-0.8	-0.4	1.3	-1.3
Pavlov. Cond. magazine entry latency	0.5	0.6	0.9	-0.5	-0.8	-0.9	-0.9	-0.8	-0.3	0.8	-0.8
Pavlov. Cond. change in total contacts	0.7	1.0	1.6	0.9	1.3	0.9	0.8	0.8	0.8	-1.2	1.2
Pavlov. Cond. index score	0.3	0.3	0.5	0.6	0.7	0.4	0.3	0.5	0.6	-0.7	0.7
Pavlov. Cond. latency score	0.3	0.4	0.5	0.6	0.7	0.4	0.4	0.5	0.6	-0.7	0.7
Pavlov. Cond. lever contacts	0.7	0.9	1.2	1.0	1.1	1.0	0.9	0.9	0.5	-1.1	1.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.0	-0.2	0.0	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.1	-0.3	-0.2	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	0.5	0.7	0.4	0.3	0.5	0.6	-0.7	0.7
Pavlov. Cond. response bias	0.4	0.5	0.7	0.8	0.8	0.7	0.7	0.7	0.4	-0.9	0.8
Conditioned reinforcement - actives	0.2	0.2	0.4	0.7	0.3	0.5	0.6	0.3	0.1	-0.4	0.4
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.3	0.1	0.3	0.2	0.2	0.4	-0.2	0.2
Conditioned locomotion	1.0	1.2	1.4	1.2	0.9	1.1	1.2	1.0	1.2	-1.1	1.0
Intermittent access intake day 1-15 change	0.9	0.9	1.2	-0.8	-1.0	-1.0	-1.1	-1.0	0.3	1.0	-1.0
Intermittent access intake escalation	0.7	0.7	0.9	-0.6	-0.9	-0.9	-0.9	-0.9	0.5	0.8	-0.9
Intermittent access intake escalation 2	0.6	0.6	1.0	-0.5	-0.8	-0.8	-0.9	-1.0	-0.3	0.7	-0.8
Intermitt. access day 1 inactive lever presses	0.2	0.2	1.2	0.0	0.4	0.1	-0.1	0.6	1.1	-0.3	0.3
Intermitt. access day 15 inactive lever presses	0.6	0.7	4.8	0.5	0.3	0.3	0.3	0.3	2.2	-0.4	0.3
Intermitt. access escalation Index	0.4	0.4	2.9	0.3	0.0	0.1	0.0	-0.0	-1.7	-0.1	0.1
Intermittent access day 1 total infusions	0.3	0.3	1.9	-0.3	-0.4	-0.2	0.0	-0.1	-1.4	0.4	-0.4
Intermittent access day 15 total infusions	0.7	0.8	1.1	-0.7	-1.0	-0.9	-0.8	-0.8	-0.9	1.0	-1.0
Intermittent access terminal intake (last 3 days)	1.8	1.9	2.5	-1.1	-1.6	-1.4	-1.3	-1.4	-1.1	1.5	-1.5
Intermittent access total infusions	0.7	0.8	1.2	-0.7	-1.1	-0.9	-0.8	-0.8	-0.6	1.0	-1.1
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.3	-0.4	-0.2	-0.1	-0.2	0.3	0.4	-0.4
Intermittent access day 15 total locomotion	0.4	0.4	2.8	-0.1	0.1	0.2	0.3	0.3	1.7	-0.1	0.1
Intermittent access total locomotion	0.4	0.5	1.4	-0.5	-0.7	-0.5	-0.5	-0.5	1.2	0.7	-0.7
Intermittent access standard deviation	0.2	0.3	1.3	-0.2	-0.4	-0.4	-0.4	-0.3	1.1	0.4	-0.4
Cocaine induced anxiety	2.2	2.5	8.3	1.1	1.3	1.3	1.3	1.3	2.9	-1.3	1.3
Post-drug Anxiety	3.2	3.6	4.7	1.6	2.2	2.0	1.9	2.1	0.6	-2.1	2.1
Baseline Anxiety	1.6	1.7	12.7	-0.3	-0.3	-0.4	-0.4	-0.4	-3.6	0.3	-0.3
Lifetime Intake	0.4	0.5	0.7	-0.5	-0.8	-0.6	-0.6	-0.5	-0.7	0.8	-0.8
Incentive Sensitization - Responses	1.2	1.2	1.9	-0.7	-1.1	-1.1	-0.9	-1.3	-1.4	1.0	-1.1
Incentive Sensitization - Breakpoint	1.2	1.2	2.3	-0.6	-1.1	-1.1	-0.9	-1.2	-1.5	1.0	-1.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	0.0	0.2	0.0	-0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.1	-0.2	0.0	0.0	-0.1	0.1	0.1	-0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.2	-0.0	0.1	0.1	0.1	0.3	0.4	-0.1	0.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	-0.2	-0.6	-0.5	-0.3	-0.6	-0.2	0.5	-0.5
Progressive ratio test 2 breakpoint	0.5	0.5	0.8	-0.4	-0.9	-0.7	-0.6	-0.9	-0.5	0.8	-0.8
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.5	0.2	-0.1	0.0	0.0	-0.1	-0.7	0.0	-0.1
Total sessions with >9 infusions	0.6	0.7	1.0	-0.7	-1.0	-0.9	-0.8	-0.8	-0.6	0.9	-1.0
Short access day 1 total inactive lever presses	0.3	0.3	1.4	0.3	0.4	0.3	-0.0	0.6	1.2	-0.4	0.4
Short access day 10 total inactive lever presses	0.4	0.4	3.2	0.1	0.3	0.1	-0.1	0.2	1.8	-0.3	0.3
Short access day 1 total infusions	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.1	-0.0	-0.6	0.3	-0.2
Short access day 10 total infusions	0.3	0.4	0.7	-0.6	-0.7	-0.5	-0.3	-0.4	-0.8	0.7	-0.7
Short access total infusions	0.0	0.0	0.2	-0.1	-0.1	-0.0	0.0	0.2	-0.5	0.1	-0.1
Short access day 1 locomotion	0.6	0.7	2.8	-0.7	-0.6	-0.6	-0.4	-0.4	-1.7	0.7	-0.7
Short access day 10 total locomotion	0.4	0.5	2.8	-0.3	-0.5	-0.3	-0.3	-0.4	1.7	0.5	-0.5
Short access total locomotion	0.1	0.1	0.2	0.2	0.3	0.3	0.4	0.4	0.4	-0.3	0.3
Compulsive drug intake	0.3	0.3	0.5	0.7	0.6	0.7	0.7	0.5	-0.0	-0.6	0.6
One hour access (0.3 mA shock)	2.5	2.9	3.9	-1.1	-1.9	-1.5	-1.6	-2.0	-1.7	1.8	-1.8
One hour access (shock baseline)	0.8	0.9	1.3	-0.5	-1.1	-0.9	-0.9	-1.0	-1.0	1.0	-1.1
Number of responses in last shaping day	2.2	2.3	2.8	1.3	1.6	1.6	1.5	1.7	1.1	-1.6	1.6
Context. condit. distance diff. score	3.0	3.6	5.3	1.4	2.2	1.9	2.2	2.3	0.3	-2.0	2.1
Locomotion velocity, session 1	0.4	0.4	1.0	-1.0	-0.6	-0.3	-0.3	-0.4	0.5	0.8	-0.7
Locomotion distance, session 1	0.3	0.4	0.9	-0.9	-0.5	-0.1	-0.3	-0.3	-0.9	0.7	-0.6
Locomotion velocity, session 2	0.2	0.2	0.6	0.7	0.3	0.8	0.2	0.2	-0.2	-0.5	0.4
Locomotion distance, session 2	0.9	1.2	2.6	-0.2	-1.2	-0.9	-1.3	-1.3	-1.6	0.9	-1.0
Locomotion velocity, session 3	0.2	0.2	0.7	-0.8	-0.4	-0.2	-0.0	-0.2	0.2	0.6	-0.5
Locomotion distance, session 3	0.1	0.1	0.5	-0.2	0.1	0.4	0.7	0.2	0.4	0.0	0.1
Stereotopy head waving bouts, day 3	1.4	1.7	3.5	-1.9	-1.3	-1.5	-1.1	-1.0	-0.2	1.5	-1.5
Stereotopy head waving duration, day 3	1.7	2.1	2.9	-1.7	-1.6	-1.5	-1.4	-1.2	-0.5	1.7	-1.6
Locomotion velocity, session 7	3.4	3.7	5.4	1.1	2.1	2.3	1.9	1.9	2.0	-1.9	2.0
Locomotion distance, session 7	0.0	0.0	0.1	0.2	0.2	0.0	-0.0	0.0	0.1	-0.2	0.2
Stereotopy head waving bouts, day 7	0.3	0.3	0.7	0.1	0.5	0.6	0.9	0.7	0.7	-0.4	0.5
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.6	-0.1	0.0	0.3	0.2	0.2	0.2	-0.2
Locomotion velocity, session 8	2.5	3.0	4.2	1.1	2.0	2.0	2.0	2.0	0.4	-1.8	1.9
Locomotion distance, session 8	1.3	1.9	2.4	1.2	1.5	1.4	1.6	1.6	-0.6	-1.5	1.5
Degree of sensitization distance	0.2	0.2	0.9	-0.1	-0.3	-0.6	-1.0	-0.4	-0.4	0.2	-0.3
Degree of sensitization stereotypy	1.3	1.4	2.3	0.7	1.2	1.4	1.5	1.3	0.9	-1.1	1.2
Condit. Reinf. active minus inactive responses	2.7	3.0	4.2	-1.1	-2.0	-2.0	-1.9	-2.0	-0.2	1.8	-1.9
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.5	-0.6	-1.6	-1.5	-1.2	-1.5	-0.3	1.3	-1.4
Condit. Reinf. active responses	0.5	0.6	1.2	-0.1	-0.7	-1.1	-0.9	-1.0	0.3	0.6	-0.7
Condit. Reinf. inactive responses	0.9	1.1	1.9	1.4	1.2	0.7	0.6	0.8	0.7	-1.3	1.3
Incentive salience index mean	2.6	3.2	4.5	-1.1	-2.0	-2.1	-2.1	-2.1	-0.2	1.8	-1.9
Condit. Reinf. lever presses	1.0	1.3	2.6	-0.5	-1.2	-1.3	-1.6	-1.5	0.2	1.0	-1.1
Time in familiar zone, hab. session 1	0.5	0.5	1.3	1.1	0.8	0.2	0.4	0.5	0.2	-1.0	0.9
Time in novel zone, hab. session 1	0.3	0.3	0.8	0.4	0.5	0.9	0.7	0.5	-0.1	-0.5	0.5
Total zone transitions, hab. session 1	0.1	0.2	0.6	-0.8	-0.3	-0.4	-0.5	-0.2	-0.4	0.4	-0.4
Total locomotion distance, hab. session 1	1.0	1.4	2.1	-1.4	-1.2	-1.2	-1.2	-1.0	-0.9	1.3	-1.3
Locomotion velocity, hab. session 1	1.9	2.7	4.1	-2.0	-1.6	-1.7	-1.8	-1.4	-0.9	1.8	-1.8
Time in familiar zone, hab. session 2	0.2	0.2	0.8	-0.2	-0.2	-0.9	-0.8	-0.4	-0.1	0.2	-0.2
Time in novel zone, hab. session 2	0.3	0.3	0.9	0.3	0.2	1.0	1.0	0.4	-0.0	-0.3	0.3
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.1	0.2	0.2	0.2	0.3	-0.6	-0.1	0.1
Total locomotion distance, hab. session 2	0.3	0.3	1.0	-0.7	-0.4	-0.4	-0.5	-0.4	-1.0	0.5	-0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.9	-0.5	-0.4	-0.3	-0.5	-0.3	-0.9	0.4	-0.4
Novel to familiar place preference ratio	0.7	0.7	1.0	1.0	0.8	1.0	0.9	0.8	0.3	-0.9	0.9
Novelty place preference	0.6	0.6	0.9	1.0	0.7	1.0	0.8	0.7	0.3	-0.9	0.8
Time in novel zone, NPP test	0.5	0.5	0.8	0.8	0.6	0.9	0.7	0.6	0.4	-0.7	0.7
Total zone transitions, NPP test	0.3	0.4	0.9	0.5	0.6	0.9	0.7	0.8	-0.4	-0.6	0.6
Total locomotion distance, NPP test	0.1	0.1	0.5	-0.2	-0.2	0.0	-0.1	-0.0	-0.7	0.2	-0.2
Locomotion velocity, NPP test	0.0	0.1	0.4	-0.0	0.0	0.2	0.1	0.2	-0.6	-0.0	0.1
Pavlov. Cond. lever latency	0.5	0.7	1.4	0.4	0.8	1.2	1.1	0.8	-0.6	-0.7	0.7
Pavlov. Cond. magazine entry latency	2.2	2.9	5.0	-1.0	-1.9	-1.9	-2.2	-2.0	-0.4	1.7	-1.8
Pavlov. Cond. change in total contacts	0.6	0.6	1.1	-0.2	-0.8	-0.9	-1.1	-1.0	-0.2	0.7	-0.7
Pavlov. Cond. index score	1.8	2.2	3.9	-0.8	-1.6	-1.8	-2.0	-1.8	-0.2	1.4	-1.5
Pavlov. Cond. latency score	1.3	1.7	3.1	-0.8	-1.4	-1.6	-1.8	-1.5	0.1	1.2	-1.3
Pavlov. Cond. lever contacts	0.9	1.1	2.2	-0.5	-1.0	-1.3	-1.5	-1.1	0.4	0.9	-1.0
Pavlov. Cond. magazine entry number	2.8	3.5	5.7	1.1	2.1	2.1	2.4	2.3	0.2	-1.8	2.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.6	0.5	0.3	0.5	0.4	0.1	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.6	1.9	3.2	-0.7	-1.5	-1.7	-1.8	-1.7	-0.3	1.3	-1.4
Pavlov. Cond. response bias	2.5	3.0	5.2	-1.0	-1.9	-2.1	-2.3	-2.0	-0.0	1.7	-1.8
Bone: apparent density	0.6	1.0	1.8	0.9	1.1	1.3	0.8	1.0	0.3	-1.1	1.1
Bone surface	0.1	0.1	0.3	0.5	0.2	0.5	0.2	0.2	0.0	-0.3	0.3
Bone volume	0.3	0.6	1.1	0.6	0.7	1.0	0.8	0.8	-0.1	-0.8	0.8
Bone: connectivity density	0.2	0.3	0.4	0.6	0.5	0.7	0.2	0.4	0.6	-0.6	0.5
Bone: cortical apparent density	0.0	0.0	0.1	0.3	0.1	0.3	0.0	-0.0	0.1	-0.1	0.1
Bone: cortical area	0.2	0.4	0.8	0.9	0.5	0.7	0.6	0.5	0.1	-0.7	0.6
Bone: cortical porosity	0.3	0.3	0.6	0.8	0.5	0.4	0.4	0.3	0.8	-0.7	0.6
Bone: cortical porosity	0.0	0.0	0.2	0.3	0.1	-0.0	-0.0	-0.0	0.4	-0.2	0.2
Bone: cortical thickness	2.0	3.2	4.0	2.0	1.8	1.9	1.6	1.7	1.2	-2.0	2.0
Bone: cortical thickness	1.8	2.1	3.3	1.8	1.5	1.4	1.5	1.4	-0.3	-1.7	1.6
Bone: cortical tissue density	0.0	0.0	0.0	0.2	-0.1	0.1	-0.1	-0.1	0.1	-0.0	-0.0
Bone: elastic displacement	2.0	2.3	3.0	1.6	1.6	1.5	1.2	1.3	1.5	-1.7	1.7
Bone: elastic work	3.6	4.7	5.7	2.1	2.3	2.1	2.0	2.1	1.8	-2.4	2.4
Bone: endosteal estimation	1.1	2.3	3.4	-1.8	-1.7	-1.4	-1.0	-1.3	-1.2	1.8	-1.8
Bone: endosteal perimeter	1.0	2.0	2.9	-1.2	-1.7	-1.3	-1.1	-1.5	-1.1	1.6	-1.6
Bone: final force	0.9	1.5	2.6	0.6	1.3	1.3	1.6	1.5	0.3	-1.2	1.2
Bone: final moment	0.8	1.3	2.4	0.7	1.2	1.4	1.5	1.4	0.2	-1.1	1.2
Bone: marrow area	1.1	2.3	3.3	-1.7	-1.7	-1.4	-1.0	-1.3	-1.1	1.8	-1.8
Bone: maximum diameter	0.1	0.1	0.2	0.2	-0.5	-0.2	-0.3	-0.5	-0.5	0.3	-0.4
Bone: maximum force	0.8	1.3	2.0	0.8	1.3	1.3	1.4	1.4	0.3	-1.2	1.2
Bone: maximum moment	0.8	1.4	2.1	0.9	1.2	1.4	1.4	1.3	0.3	-1.2	1.2
Bone: minimum diameter	0.0	0.1	0.1	-0.2	-0.3	-0.2	-0.1	-0.1	-0.2	0.3	-0.3
Bone: periosteal estimation	0.1	0.2	0.4	-0.4	-0.6	-0.3	-0.2	-0.4	-0.4	0.6	-0.6
Bone: periosteal perimeter	0.2	0.3	0.5	-0.2	-0.7	-0.4	-0.4	-0.6	-0.5	0.6	-0.6
Bone: post-yield work	1.7	2.3	2.9	-1.4	-1.5	-1.6	-1.7	-1.5	-1.3	1.6	-1.6
Bone: stiffness	0.2	0.3	0.7	-0.1	0.5	0.6	0.8	0.7	-0.2	-0.3	0.4
Bone: tissue strength	0.4	0.4	1.0	-0.6	0.6	0.8	0.6	0.7	1.0	-0.2	0.3
Bone: trabecular number	0.5	0.8	1.3	0.8	1.0	1.1	0.8	0.9	0.5	-1.0	1.0
Bone: trabecular spacing	0.6	0.8	1.1	-0.8	-0.9	-1.0	-0.8	-0.9	-0.7	0.9	-0.9
Bone: trabecular thickness	0.8	0.9	1.7	0.4	1.0	1.3	1.1	1.2	0.0	-0.9	1.0
Bone: trabecular tissue density	0.6	0.9	1.4	1.1	0.9	1.2	0.8	0.8	0.4	-1.0	1.0
Breakpoint value in progressive ratio session	1.0	1.2	1.8	-0.7	-1.3	-1.2	-1.2	-1.1	-0.1	1.2	-1.3
Distance traveled before self-admin	0.4	0.4	2.3	0.4	0.5	0.4	0.4	-0.1	-1.5	-0.5	0.5
Distance traveled after self-admin	1.4	1.5	10.6	-0.2	-0.6	-0.4	-0.5	-0.6	3.3	0.5	-0.5
Delta time in closed arm before/after self-admin	3.5	3.3	22.4	-0.8	-0.7	-0.8	-0.9	-0.6	-4.7	0.8	-0.8
Delta time in open arm before/after self-admin	0.3	0.3	0.8	0.5	0.4	0.6	0.6	0.3	0.9	-0.5	0.4
Diff in mean of infusions in LGA sessions	0.6	0.7	4.7	0.3	0.5	0.5	0.4	0.1	2.2	-0.5	0.4
Extinction: sum of active levers before priming	0.8	0.9	5.1	0.1	-0.8	-0.4	-0.4	-0.5	-2.3	0.5	-0.6
Active lever presses in extinction session 6	1.9	1.9	6.1	0.8	1.2	1.2	1.2	1.0	2.5	-1.2	1.2
Delta distance traveled before/after self-admin	1.5	1.6	3.3	-0.9	-1.3	-1.2	-1.2	-0.9	1.8	1.2	-1.3
Delta ambulatory time before/after self-admin	1.4	1.5	2.4	-1.0	-1.3	-1.2	-1.3	-0.9	1.5	1.3	-1.3
Time in closed arm before self-admin	1.1	1.3	2.9	-0.4	-1.2	-1.0	-1.0	-1.3	-1.7	1.0	-1.1
Time in closed arm after self-admin	4.1	4.3	27.3	-0.8	-1.1	-1.0	-1.1	-0.8	-5.2	1.1	-1.1
Time in open arm before self-admin	0.6	0.6	2.9	-0.9	-0.3	-0.7	-0.6	-0.2	1.7	0.5	-0.4
Time in open arm after self-admin	3.6	4.0	27.3	0.5	0.9	0.8	1.0	0.7	5.2	-0.8	0.8
Sum of active levers in priming session hrs 5-6	1.3	1.2	9.0	0.6	0.3	0.5	0.3	0.1	3.0	-0.4	0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.3	0.3	0.2	0.2	0.3	-0.3	-0.3	0.3
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.2	0.8	1.1	1.0	0.8	1.0	-0.3	-1.1	1.1
Time to tail flick, test, before self-admin	0.5	0.5	2.8	0.3	0.4	0.3	0.4	0.3	1.7	-0.4	0.4
Time to tail flick, test, after self-admin	1.4	1.4	6.4	-0.3	-1.0	-0.9	-1.0	-0.9	-2.5	0.8	-0.9
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.1	0.3	0.3	0.2	0.3	0.5	-0.3	0.3
Delta time to tail flick, test, before/after SA	2.2	2.0	6.7	-1.0	-1.1	-1.2	-1.3	-0.9	-2.6	1.2	-1.2
Ambulatory time before self-admin	0.9	1.0	1.2	1.0	1.0	1.1	1.1	0.9	-0.8	-1.0	1.0
Ambulatory time after self-admin	1.3	1.4	6.7	-0.4	-1.0	-0.7	-0.8	-0.9	2.6	0.8	-0.9
Total heroin consumption	5.1	6.1	10.8	-1.3	-2.6	-2.2	-2.3	-2.8	-3.3	2.3	-2.4
Area under the delay curve	1.8	1.9	2.3	1.4	1.5	1.5	1.5	1.4	0.5	-1.5	1.5
Delay disc. indifference point, 0s delay	1.7	1.8	5.6	1.1	1.1	1.1	1.1	1.2	-2.4	-1.1	1.1
Delay disc. indifference point, 16s delay	0.9	0.9	1.0	1.0	0.9	1.0	1.0	0.8	0.7	-1.0	1.0
Delay disc. indifference point, 2s delay	2.8	3.1	4.2	1.2	1.9	1.6	1.6	2.0	2.0	-1.8	1.8
Delay disc. indifference point, 24s delay	0.6	0.6	2.9	0.8	0.3	0.6	0.6	0.1	-1.7	-0.5	0.4
Delay disc. indifference point, 4s delay	0.8	0.8	1.2	0.5	1.1	0.9	0.9	1.1	0.8	-1.0	1.0
Delay disc. indifference point, 8s delay	1.3	1.4	1.6	1.2	1.2	1.3	1.3	1.1	0.6	-1.3	1.3
Delay discount exponential model param	1.7	1.8	2.1	-1.3	-1.4	-1.4	-1.4	-1.3	-0.7	1.5	-1.4
Delay discount hyperbolic model param	1.9	2.0	2.4	-1.4	-1.5	-1.5	-1.5	-1.5	-0.9	1.5	-1.5
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	-0.8	-0.3	-0.5	-0.6	-0.0	0.0	0.5	-0.4
Change in fecal boli incidents, locomotor task	1.2	1.2	7.4	0.6	0.5	0.5	0.5	0.5	-2.7	-0.5	0.5
Time >=10cm from walls, locomotor time 1	0.9	0.9	6.2	-0.4	-0.2	-0.4	-0.4	-0.3	2.5	0.3	-0.3
Bouts of movement, locomotor time 1	0.8	0.9	1.1	-0.8	-1.1	-1.0	-1.0	-1.1	-0.0	1.0	-1.1
Total resting periods, locomotor time 1	0.9	1.0	1.3	-1.0	-1.1	-1.1	-1.1	-1.1	0.2	1.1	-1.1
Rest time, locomotor task time 1	1.7	1.8	8.4	-0.3	1.2	0.7	0.8	1.6	2.9	-0.8	0.9
Distance moved, locomotor task time 1	0.9	1.0	4.4	1.5	0.1	0.6	0.6	-0.4	-2.1	-0.6	0.4
Vertical activity count, locomotor time 1	0.7	0.7	1.8	1.3	0.5	0.8	0.6	0.3	1.3	-0.8	0.7
Time >=10cm from walls, locomotor time 2	1.9	2.1	4.2	0.9	1.4	1.4	1.4	1.4	2.1	-1.3	1.4
Bouts of movement, locomotor time 2	0.3	0.3	0.6	0.4	0.6	0.6	0.8	0.5	-0.3	-0.6	0.6
Total resting periods, locomotor time 2	0.7	0.7	1.1	0.5	1.0	0.9	1.0	0.9	0.6	-0.9	0.9
Rest time, locomotor task time 2	1.5	1.7	7.2	0.0	1.3	0.8	0.8	1.3	2.7	-0.9	1.0
Distance moved, locomotor task time 2	0.8	0.9	2.1	1.5	0.6	1.1	1.0	0.4	-0.8	-0.9	0.8
Vertical activity count, locomotor time 2	2.0	2.2	3.7	1.9	1.3	1.7	1.5	1.2	0.9	-1.6	1.5
Weight adjusted by age	0.7	0.8	1.2	1.1	0.8	1.0	1.0	0.6	0.3	-0.9	0.9
Seeking ratio, delayed vs. immediate footshock	1.9	2.2	10.9	-0.9	-1.0	-1.1	-1.0	-1.0	-3.3	1.0	-1.0
Locomotion in novel chamber	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.4	-0.3	-0.4	0.3	-0.3
Locomotion in novel chamber post-restriction	0.2	0.2	0.7	0.6	0.2	0.4	0.3	0.2	-0.8	-0.4	0.3
Progressive ratio	0.0	0.1	0.3	-0.3	-0.0	-0.1	-0.1	-0.0	0.6	0.1	-0.1
Food seeking constrained by brief footshock	2.3	2.9	15.7	-0.6	-1.1	-1.0	-0.9	-1.2	-4.0	1.0	-1.1
Seeking ratio, punishment vs. effort	1.8	2.3	10.1	-0.7	-1.2	-1.0	-1.0	-1.2	-3.2	1.1	-1.1
Run reversals in cocaine runway, females	0.3	0.3	1.5	-0.7	-0.1	-0.4	-0.2	0.1	1.2	0.3	-0.3
Run reversals in cocaine runway, males	0.3	0.3	1.1	-0.5	-0.3	-0.5	-0.3	-0.2	-1.0	0.4	-0.4
Latency to leave start box in cocaine runway	0.5	0.5	3.4	0.7	0.1	0.4	0.2	-0.1	-1.8	-0.3	0.2
Latency to leave start box in cocaine runway, F	0.8	0.9	6.7	0.2	-0.3	-0.2	-0.3	-0.5	-2.6	0.2	-0.3
Latency to leave start box in cocaine runway, M	1.1	1.1	1.5	1.2	1.1	1.2	1.1	0.9	0.4	-1.2	1.1
Cd content in liver	0.6	0.7	1.9	0.3	0.9	0.8	0.5	0.7	1.4	-0.7	0.8
Co content in liver	0.5	0.6	1.1	-0.2	-0.8	-0.8	-1.0	-0.9	-0.7	0.6	-0.7
Cu content in liver	0.1	0.1	0.2	-0.3	0.4	-0.1	-0.2	0.3	0.4	-0.2	0.2
Fe content in liver	0.3	0.3	1.1	1.1	0.5	0.2	-0.0	0.2	0.4	-0.7	0.6
K content in liver	0.2	0.2	1.4	-1.2	-0.1	-0.1	0.2	0.3	-0.3	0.5	-0.3
Mg content in liver	0.3	0.3	1.6	-1.3	-0.2	-0.1	0.2	0.2	0.1	0.5	-0.4
Mn content in liver	1.1	1.3	3.9	-2.0	-1.0	-0.9	-0.8	-0.7	-0.4	1.4	-1.2
Na content in liver	0.6	0.7	0.8	-0.8	-0.9	-0.7	-0.6	-0.8	-0.9	0.9	-0.9
Rb content in liver	0.0	0.0	0.2	-0.0	0.1	0.0	0.2	0.2	-0.5	-0.1	0.1
Se content in liver	0.4	0.5	2.0	-1.4	-0.4	-0.5	-0.4	-0.2	0.2	0.8	-0.7
Sr content in liver	0.2	0.2	0.5	0.0	-0.6	-0.3	-0.3	-0.7	-0.7	0.4	-0.5
Zn content in liver	0.7	0.7	1.0	-0.9	-0.8	-0.9	-1.0	-0.8	-0.3	0.9	-0.9