Itga2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000058111	0.03	0.02	1.4e-03	0.01	0.01	0.01	0	3.5e-02	2.0e-02	3.1e-02	7.6e-02
2	Eye	gene expression	ENSRNOG00000058111	0.62	0.15	9.4e-05	0.16	0.14	0.11	0.14	2.0e-03	3.5e-03	9.6e-03	3.8e-03
3	NAcc	gene expression	ENSRNOG00000058111	0.38	0.11	0.0e+00	0.37	0.34	0.36	0.36	4.9e-29	4.1e-26	1.2e-27	2.8e-28

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	0.1	0.3	0.7	0.4	0.0	-0.9
BMI without tail	1.7	3.6	5.1	2.1	-1.1	-2.3
Body weight	1.4	5.7	7.6	2.4	-1.9	-2.8
Epididymis fat weight	0.4	0.9	1.6	1.3	0.5	-1.0
Glucose	0.0	0.0	0.1	0.0	0.3	0.1
Heart weight	0.4	0.5	0.9	0.8	-0.1	-0.9
Left kidney weight	0.5	1.3	2.0	1.4	-0.7	-1.2
Right kidney weight	0.3	0.8	1.5	1.2	-0.1	-1.0
Tail length	2.3	6.9	9.5	3.1	-1.7	-2.9
Length with tail	1.7	6.1	8.4	2.9	-1.8	-2.5
Length without tail	0.0	0.0	0.0	0.1	-0.0	-0.0
Liver weight, left	0.4	0.7	1.7	-0.0	1.3	0.5
Liver weight, right	1.7	2.8	4.4	-2.1	0.7	1.9
Parametrial fat weight	0.0	0.0	0.0	0.0	0.1	-0.1
Retroperitoneal fat weight	0.3	1.2	1.9	1.1	-0.5	-1.4
Intraocular pressure	1.5	2.2	5.4	0.0	2.3	1.0
Extensor digitorum longus weight	2.4	9.6	12.4	2.6	-3.5	-3.1
Soleus weight	7.0	20.4	33.8	5.8	-1.6	-5.0
Tibialis anterior weight	3.3	11.5	13.6	3.5	-2.9	-3.7
Tibia length	0.0	0.1	0.2	0.5	0.2	-0.1
Number of licking bursts	0.1	0.2	0.3	0.5	0.4	-0.2
Food consumed during 24 hour testing period	0.8	0.9	1.8	-1.3	0.1	0.9
Times rat made contact with spout	2.1	2.4	3.3	1.2	-1.5	-1.8
Mean time between licks in bursts	0.6	0.8	1.7	0.8	1.3	-0.3
Mean num. licks in bursts	0.6	0.7	1.7	-0.1	-1.3	-0.6
Std. dev. time between licks in bursts	1.1	1.3	2.4	-0.5	1.5	1.2
Water consumed over 24 hours	0.6	0.7	1.4	-0.6	1.2	0.5
Indifference point 0 sec	1.2	1.9	3.2	-1.8	-0.2	1.6
Indifference point AUC	0.7	0.9	1.1	1.0	-0.7	-1.0
Indifference point function ln k	1.0	1.4	1.8	-1.2	0.9	1.3
Indifference point function log k	1.0	1.4	1.8	-1.2	0.9	1.3
Delay discounting total patch changes 0 sec	0.9	1.4	2.3	-1.5	-0.1	1.4
Delay discounting total patch changes 12 sec	0.1	0.2	0.6	0.2	-0.7	-0.1
Delay discounting total patch changes 18 sec	0.6	0.8	1.0	-1.0	0.6	1.0
Delay discounting total patch changes 24 sec	0.2	0.3	0.7	0.1	-0.9	-0.2
Delay discounting total patch changes 6 sec	0.1	0.2	0.4	-0.4	-0.7	0.1
Delay discounting time to switch 0 sec	0.1	0.1	0.3	-0.5	-0.1	0.2
Delay discounting water rate 0 sec	0.3	0.5	1.0	0.7	1.0	0.2
Delay discounting water rate 12 sec	1.1	1.7	2.7	1.7	-0.2	-1.5
Delay discounting water rate 18 sec	0.2	0.2	0.3	0.5	0.5	-0.5
Delay discounting water rate 24 sec	0.1	0.1	0.2	-0.2	0.4	-0.2
Delay discounting water rate 6 sec	0.5	0.8	2.0	-0.2	1.4	0.5
Locomotor activity	2.0	3.2	4.5	2.1	-0.8	-2.1
Locomotor testing distance	1.0	1.6	2.0	1.4	-1.0	-1.4
Locomotor testing rearing	0.1	0.2	0.4	0.3	0.7	-0.2
Light reinforcement 1	0.2	0.5	1.2	0.4	1.1	0.0
Light reinforcement 2	1.2	1.6	3.3	-0.4	1.8	1.1
Reaction time number correct	0.4	0.6	1.0	-1.0	0.4	0.9
Reaction time mean minus median	0.6	0.8	1.4	-0.5	1.2	0.9
Reaction time mean minus median AUC	1.4	1.8	2.6	-1.1	1.2	1.6
Reaction time num false alarms	0.9	1.3	2.1	-1.4	-0.0	1.3
Reaction time num false alarms AUC	0.8	1.1	1.9	-1.4	-0.1	1.2
Reaction time trials correct on left	0.4	0.6	1.0	-1.0	0.4	0.9
Reaction time trials on left	0.5	0.6	0.9	-1.0	0.5	0.9
Reaction time mean	1.3	1.8	2.5	-0.8	1.6	1.5
Reaction time mean AUC	1.3	1.7	2.6	-0.9	1.4	1.6
Median of all reaction times	1.3	1.8	2.5	-0.8	1.6	1.5
Reaction time omissions	0.7	0.9	1.5	-0.3	1.1	1.2
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	-0.1	0.5
Reaction time premature initiation rate	1.0	1.3	1.7	1.1	-1.3	-1.0
Reaction time premature initiations	0.6	0.8	1.7	0.6	-1.3	-0.6
Std. dev. reaction times	1.0	1.4	2.2	-0.6	1.5	1.3
Reaction time trials completed	0.5	0.6	0.9	-1.0	0.5	0.9
Reaction time trials AUC	0.4	0.6	1.0	-1.0	0.4	0.8
Social response proportion	0.4	0.4	0.7	0.7	0.8	-0.2
Social responses	0.2	0.3	0.3	-0.6	0.6	0.3
Social time	0.0	0.0	0.1	0.0	-0.2	0.1
Conditioned locomotion	0.5	0.6	0.9	0.9	-0.3	-1.0
Cocaine response after cond. corrected	0.3	0.3	0.5	0.6	0.3	-0.7
Cocaine response after cond. not corrected	0.7	0.8	1.9	-0.4	1.4	0.5
Cocaine response before conditioning	4.2	5.1	7.0	-2.3	1.7	2.7
Saline control response	0.1	0.1	0.2	-0.2	0.4	0.1
Condit. Reinf. active minus inactive responses	1.9	2.3	4.4	-2.1	0.3	1.6
Condit. Reinf. active-inactive response ratio	1.5	1.6	3.6	-1.9	-0.2	1.0
Condit. Reinf. active responses	0.5	0.6	0.9	-1.0	-0.3	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	0.3	0.5
Condit. Reinf. lever presses	3.6	4.9	8.3	-2.9	0.1	2.6
Condit. Reinf. lever reinforcers received	1.0	1.4	2.2	-1.5	0.0	1.4
Pavlov. Cond. lever latency	4.7	6.5	10.4	3.2	-0.5	-3.0
Pavlov. Cond. magazine entry latency	2.6	3.0	5.3	-2.3	0.6	1.8
Pavlov. Cond. change in total contacts	6.0	8.3	13.8	-3.7	0.8	3.3
Pavlov. Cond. index score	4.1	5.4	8.7	-3.0	0.7	2.6
Pavlov. Cond. latency score	3.7	4.7	7.9	-2.8	0.5	2.4
Pavlov. Cond. lever contacts	3.6	4.9	7.8	-2.8	0.4	2.6
Pavlov. Cond. magazine entry number	5.3	6.5	10.3	3.2	-1.2	-2.8
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.3	1.1	0.1	-0.7
Pavlov. Cond. lever-magazine prob. diff.	4.6	5.9	9.5	-3.1	1.0	2.7
Pavlov. Cond. response bias	5.6	7.8	12.2	-3.5	0.9	3.2
Conditioned reinforcement - actives	0.0	0.0	0.1	0.1	0.2	-0.3
Conditioned reinforcement - inactives	0.3	0.3	0.4	-0.6	0.4	0.6
Conditioned locomotion	0.1	0.1	0.1	0.1	0.4	0.3
Intermittent access intake day 1-15 change	0.2	0.2	0.4	-0.1	0.4	0.6
Intermittent access intake escalation	0.3	0.3	0.6	-0.2	0.4	0.8
Intermittent access intake escalation 2	0.4	0.4	0.8	-0.5	0.3	0.9
Intermitt. access day 1 inactive lever presses	0.7	0.7	1.9	-0.5	-1.4	-0.1
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.2	1.0	0.0	-1.1
Intermitt. access escalation Index	4.3	3.9	5.0	1.6	-2.2	-2.0
Intermittent access day 1 total infusions	0.3	0.3	0.5	0.7	0.4	-0.5
Intermittent access day 15 total infusions	0.3	0.3	0.5	0.6	0.7	0.3
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.8	0.9	0.3	-0.1
Intermittent access total infusions	0.4	0.5	1.1	1.1	0.1	-0.6
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.2	0.2	0.0
Intermittent access day 15 total locomotion	0.7	0.7	1.6	-0.1	1.3	0.7
Intermittent access total locomotion	0.2	0.2	0.3	-0.1	0.6	0.5
Intermittent access standard deviation	1.6	1.7	3.1	-0.4	1.7	1.4
Cocaine induced anxiety	0.0	0.0	0.0	-0.2	-0.0	-0.1
Post-drug Anxiety	0.0	0.0	0.0	-0.2	-0.2	-0.2
Baseline Anxiety	0.0	0.0	0.1	0.1	0.3	0.1
Lifetime Intake	0.2	0.2	0.3	0.6	0.5	-0.2
Incentive Sensitization - Responses	1.0	1.0	1.5	1.2	1.1	-0.6
Incentive Sensitization - Breakpoint	0.9	0.9	1.3	1.1	1.2	-0.4
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	-0.9	-0.5	-0.1
Progressive ratio test 1 breakpoint	0.3	0.3	0.6	-0.8	-0.6	-0.2
Progressive ratio test 1 inactive lever presses	0.7	0.7	1.5	0.7	-0.5	-1.2
Progressive ratio test 2 active lever presses	0.2	0.2	0.6	0.3	0.8	-0.1
Progressive ratio test 2 breakpoint	0.4	0.4	1.2	0.1	1.1	0.1
Progressive ratio test 2 inactive lever presses	1.9	2.2	3.3	1.8	0.0	-1.8
Total sessions with >9 infusions	0.0	0.0	0.1	0.3	0.0	-0.1
Short access day 1 total inactive lever presses	3.8	4.2	4.5	2.0	-2.1	-2.1
Short access day 10 total inactive lever presses	0.2	0.3	0.6	-0.4	-0.8	0.0
Short access day 1 total infusions	0.2	0.2	0.3	0.6	0.3	-0.4
Short access day 10 total infusions	0.2	0.2	0.3	-0.3	0.6	0.5
Short access total infusions	0.1	0.1	0.3	-0.0	0.6	0.1
Short access day 1 locomotion	0.3	0.3	0.8	0.2	0.9	0.3
Short access day 10 total locomotion	2.3	2.5	4.3	-1.4	1.1	2.1
Short access total locomotion	0.3	0.3	0.7	-0.5	0.3	0.8
Compulsive drug intake	0.6	0.6	1.0	-0.2	1.0	0.9
One hour access (0.3 mA shock)	0.3	0.4	0.9	0.3	0.9	0.4
One hour access (shock baseline)	0.1	0.1	0.1	0.4	0.0	-0.2
Number of responses in last shaping day	1.1	1.1	2.1	-1.4	-0.2	1.1
Context. condit. distance diff. score	0.5	0.6	1.3	-0.6	-1.1	0.2
Locomotion velocity, session 1	0.2	0.2	0.4	-0.7	-0.2	0.2
Locomotion distance, session 1	1.1	1.4	3.0	0.0	-1.7	-1.1
Locomotion velocity, session 2	1.1	1.3	1.8	1.3	-0.6	-1.3
Locomotion distance, session 2	0.6	0.8	1.4	0.3	-1.2	-1.0
Locomotion velocity, session 3	0.6	0.6	1.3	1.1	-0.4	-0.7
Locomotion distance, session 3	0.1	0.1	0.2	0.0	-0.4	-0.0
Stereotopy head waving bouts, day 3	3.8	4.5	7.6	2.8	-0.3	-2.4
Stereotopy head waving duration, day 3	2.0	2.4	4.7	2.2	0.0	-1.6
Locomotion velocity, session 7	0.2	0.2	0.2	-0.4	0.5	0.4
Locomotion distance, session 7	0.7	1.0	1.2	-0.8	1.0	1.1
Stereotopy head waving bouts, day 7	0.8	0.9	1.3	1.1	-0.2	-1.2
Stereotopy head waving duration, day 7	1.3	1.6	2.1	1.4	-0.8	-1.4
Locomotion velocity, session 8	0.5	0.6	1.2	-1.1	0.1	0.7
Locomotion distance, session 8	0.6	0.9	1.8	-1.0	-1.3	-0.1
Degree of sensitization distance	0.3	0.3	0.4	-0.4	0.6	0.5
Degree of sensitization stereotypy	0.2	0.2	0.3	0.5	-0.2	-0.5
Condit. Reinf. active minus inactive responses	1.4	1.5	2.3	-1.5	0.8	1.3
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.5	-1.1	1.2	1.2
Condit. Reinf. active responses	1.6	2.0	2.9	-1.7	1.1	1.4
Condit. Reinf. inactive responses	0.9	1.1	1.9	-1.4	0.7	0.9
Incentive salience index mean	0.4	0.5	1.0	-1.0	0.1	0.6
Condit. Reinf. lever presses	0.1	0.2	0.5	-0.3	-0.7	-0.2
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.0	-0.0	-0.2
Time in novel zone, hab. session 1	0.9	0.9	2.1	1.5	0.3	-0.6
Total zone transitions, hab. session 1	1.0	1.4	2.6	-1.6	0.9	0.9
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.3	-0.2	-0.4
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.6	0.0	-0.2
Time in familiar zone, hab. session 2	0.6	0.6	0.9	0.7	-1.0	-0.7
Time in novel zone, hab. session 2	1.0	1.0	1.2	-0.9	1.1	0.9
Total zone transitions, hab. session 2	0.6	0.8	1.3	0.0	-1.1	-1.0
Total locomotion distance, hab. session 2	1.9	2.5	4.0	1.1	-1.5	-2.0
Locomotion velocity, hab. session 2	1.9	2.6	4.2	1.2	-1.5	-2.0
Novel to familiar place preference ratio	0.8	0.9	2.0	-0.0	1.4	0.8
Novelty place preference	0.8	0.8	2.2	0.2	1.5	0.6
Time in novel zone, NPP test	0.9	1.0	2.5	0.3	1.6	0.5
Total zone transitions, NPP test	0.3	0.4	0.9	-0.3	-1.0	-0.4
Total locomotion distance, NPP test	0.3	0.5	1.2	-0.1	-1.1	-0.4
Locomotion velocity, NPP test	0.3	0.4	1.0	-0.2	-1.0	-0.3
Pavlov. Cond. lever latency	0.5	0.7	1.7	0.1	1.3	0.5
Pavlov. Cond. magazine entry latency	0.5	0.7	1.5	-0.5	1.2	0.5
Pavlov. Cond. change in total contacts	0.1	0.2	0.5	0.0	0.7	-0.1
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.1	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.3	-0.5	-0.2
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.5	-0.9	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.4	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	-0.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.0	0.2	-0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.3	0.2	-0.1
Bone: apparent density	2.6	4.4	5.7	1.8	-2.0	-2.4
Bone surface	1.2	2.2	3.1	0.7	-1.8	-1.7
Bone volume	0.8	1.3	1.9	0.5	-1.3	-1.4
Bone: connectivity density	3.1	4.9	5.7	1.9	-2.3	-2.4
Bone: cortical apparent density	5.6	7.2	9.5	-2.6	2.4	3.1
Bone: cortical area	0.0	0.0	0.0	-0.2	-0.1	0.0
Bone: cortical porosity	1.2	1.3	1.8	1.2	-1.0	-1.3
Bone: cortical porosity	0.6	0.6	1.1	0.9	-0.3	-1.0
Bone: cortical thickness	0.6	1.0	1.7	-1.1	0.4	1.3
Bone: cortical thickness	2.1	2.5	3.3	-1.4	1.5	1.8
Bone: cortical tissue density	5.4	7.0	8.9	-2.5	2.4	3.0
Bone: elastic displacement	0.2	0.2	0.3	0.5	-0.5	-0.4
Bone: elastic work	0.1	0.1	0.3	-0.1	0.6	0.1
Bone: endosteal estimation	0.3	0.8	1.5	0.8	0.0	-1.2
Bone: endosteal perimeter	1.2	2.5	4.7	1.5	-0.6	-2.2
Bone: final force	0.7	1.2	2.9	-1.7	-0.2	0.8
Bone: final moment	0.6	0.9	2.3	-1.5	-0.2	0.6
Bone: marrow area	0.4	0.9	1.7	0.9	0.1	-1.3
Bone: maximum diameter	1.9	3.5	4.8	1.8	-1.5	-2.2
Bone: maximum force	0.4	0.8	1.8	-1.3	-0.1	0.7
Bone: maximum moment	0.3	0.5	1.2	-1.1	-0.1	0.4
Bone: minimum diameter	0.3	0.6	1.7	-0.2	1.3	0.3
Bone: periosteal estimation	0.1	0.2	0.4	0.3	0.0	-0.7
Bone: periosteal perimeter	0.7	1.2	2.0	1.1	-0.6	-1.4
Bone: post-yield work	0.2	0.3	0.6	-0.8	0.4	0.5
Bone: stiffness	0.2	0.3	0.8	-0.9	0.0	0.5
Bone: tissue strength	0.8	0.8	1.8	-0.6	-1.3	-0.4
Bone: trabecular number	1.8	2.8	4.3	1.2	-2.1	-1.7
Bone: trabecular spacing	1.1	1.4	2.0	-0.8	1.4	1.2
Bone: trabecular thickness	0.2	0.2	0.5	-0.3	-0.7	-0.1
Bone: trabecular tissue density	0.9	1.3	2.0	-1.4	0.5	1.3
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.5	0.2	-0.2
Distance traveled before self-admin	1.2	1.3	3.0	-0.0	-1.7	-0.9
Distance traveled after self-admin	0.5	0.5	0.8	-0.9	-0.8	0.4
Delta time in closed arm before/after self-admin	0.5	0.5	1.4	0.2	1.2	0.1
Delta time in open arm before/after self-admin	1.2	1.2	2.1	-1.4	-0.8	0.9
Diff in mean of infusions in LGA sessions	0.7	0.8	1.2	-0.7	1.1	0.9
Extinction: sum of active levers before priming	0.5	0.5	0.9	0.9	-0.0	-0.7
Active lever presses in extinction session 6	0.3	0.2	0.3	0.6	0.6	-0.3
Delta distance traveled before/after self-admin	0.6	0.7	1.1	-0.8	0.4	1.1
Delta ambulatory time before/after self-admin	0.4	0.5	0.9	-0.7	0.1	1.0
Time in closed arm before self-admin	0.4	0.5	1.3	0.3	1.1	0.1
Time in closed arm after self-admin	1.1	1.2	1.6	1.3	1.3	-0.6
Time in open arm before self-admin	0.3	0.3	0.5	0.7	-0.6	-0.4
Time in open arm after self-admin	0.5	0.6	1.0	-0.7	-1.0	0.5
Sum of active levers in priming session hrs 5-6	5.9	5.8	8.9	3.0	-1.7	-2.4
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.4	-0.9	-1.2	-0.3
Time to tail flick, vehicle, after self-admin	0.6	0.6	0.9	0.8	-0.5	-1.0
Time to tail flick, test, before self-admin	1.2	1.2	1.5	1.2	-0.9	-1.2
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.3	0.8	-0.2
Delta time to tail flick, vehicle, before/after SA	1.3	1.2	2.8	1.7	0.2	-0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.2	0.5	-0.2
Ambulatory time before self-admin	1.1	1.2	2.3	0.3	-1.5	-1.1
Ambulatory time after self-admin	0.3	0.3	0.4	-0.7	-0.4	0.5
Total heroin consumption	0.2	0.2	0.5	0.4	0.7	0.2
Area under the delay curve	1.1	1.1	2.0	-0.5	1.4	1.1
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	-0.1	0.7	0.6
Delay disc. indifference point, 16s delay	0.4	0.4	0.6	-0.8	0.3	0.8
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	0.7	0.5	-0.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.0	-0.2	0.1
Delay disc. indifference point, 4s delay	2.4	2.5	5.0	-0.4	2.2	1.5
Delay disc. indifference point, 8s delay	0.4	0.5	1.1	0.2	1.0	0.6
Delay discount exponential model param	1.2	1.3	2.4	0.4	-1.6	-1.1
Delay discount hyperbolic model param	1.0	1.0	2.3	0.2	-1.5	-0.9
Fecal boli incidents, locomotor time 1	1.1	1.2	2.2	0.6	-1.0	-1.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.0	-0.1	0.1
Time >=10cm from walls, locomotor time 1	0.7	0.8	1.5	0.8	-0.4	-1.2
Bouts of movement, locomotor time 1	0.3	0.3	0.6	0.8	-0.3	-0.6
Total resting periods, locomotor time 1	0.2	0.3	0.4	0.7	-0.2	-0.6
Rest time, locomotor task time 1	0.1	0.2	0.2	-0.3	0.5	0.4
Distance moved, locomotor task time 1	0.3	0.3	0.6	0.0	-0.8	-0.5
Vertical activity count, locomotor time 1	0.5	0.5	1.1	0.3	-1.0	-0.5
Time >=10cm from walls, locomotor time 2	2.4	2.6	3.6	1.9	-1.0	-1.7
Bouts of movement, locomotor time 2	0.5	0.5	1.0	0.4	1.0	0.6
Total resting periods, locomotor time 2	0.8	0.8	1.7	0.2	1.3	0.8
Rest time, locomotor task time 2	2.3	2.7	2.8	-1.6	1.6	1.7
Distance moved, locomotor task time 2	0.8	1.0	1.4	1.2	-0.6	-1.1
Vertical activity count, locomotor time 2	1.2	1.3	1.7	1.0	-1.3	-1.1
Weight adjusted by age	0.3	0.3	0.5	0.4	-0.7	-0.5
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.5	1.2	0.3	-0.7
Locomotion in novel chamber	0.0	0.1	0.2	0.0	0.4	0.1
Locomotion in novel chamber post-restriction	0.3	0.3	0.5	-0.7	0.2	0.7
Progressive ratio	1.5	1.7	2.4	1.6	-0.7	-1.5
Food seeking constrained by brief footshock	0.9	1.1	1.5	1.2	-0.5	-1.2
Seeking ratio, punishment vs. effort	0.6	0.7	1.0	-0.9	0.6	1.0
Run reversals in cocaine runway, females	1.6	1.6	2.4	-1.6	0.7	1.4
Run reversals in cocaine runway, males	0.4	0.4	0.7	0.6	0.8	0.2
Latency to leave start box in cocaine runway	0.3	0.3	0.8	-0.1	0.9	0.1
Latency to leave start box in cocaine runway, F	0.5	0.5	0.7	-0.7	0.8	0.5
Latency to leave start box in cocaine runway, M	0.6	0.6	1.2	1.1	0.3	-0.7
Cd content in liver	5.2	5.7	8.0	-2.6	1.5	2.8
Co content in liver	0.3	0.4	0.6	-0.8	-0.2	0.6
Cu content in liver	1.4	1.7	4.1	-0.5	2.0	0.9
Fe content in liver	0.2	0.2	0.4	0.6	0.3	-0.4
K content in liver	0.9	0.9	2.0	-0.7	-1.4	0.4
Mg content in liver	1.4	1.5	2.3	-1.5	-0.3	1.4
Mn content in liver	1.4	1.6	2.7	1.6	-1.2	-0.9
Na content in liver	0.3	0.3	0.8	-0.3	-0.9	0.1
Rb content in liver	1.4	1.7	2.5	-0.9	1.6	1.4
Se content in liver	0.6	0.7	1.0	-0.9	0.6	1.0
Sr content in liver	1.2	1.1	1.4	0.9	-1.2	-1.1
Zn content in liver	3.7	4.1	5.1	-2.2	1.5	2.3