Hub : Genes

Sppl2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000057881	0.06	0.04	4.6e-07	0.04	0.05	0.04	0.04	2.9e-05	5.7e-06	1.1e-05	1.4e-05
2	Adipose	mRNA stability	ENSRNOG00000057881	0.04	0.03	3.8e-04	0.02	0.03	0.03	0.02	2.4e-03	6.2e-04	4.5e-04	2.8e-03
3	Brain	gene expression	ENSRNOG00000057881	0.03	0.03	1.0e-03	0.01	0.02	0.01	0.01	4.0e-02	3.3e-03	1.6e-02	2.3e-02
4	Brain	isoform ratio	ENSRNOT00000109298	0.03	0.02	2.4e-03	0.02	0.02	0.02	0.01	4.5e-03	9.4e-03	1.1e-02	1.5e-02
5	Liver	gene expression	ENSRNOG00000057881	0.21	0.12	0.0e+00	0.16	0.19	0.18	0.18	1.5e-17	3.4e-20	1.1e-19	1.0e-19
6	NAcc	gene expression	ENSRNOG00000057881	0.04	0.04	8.0e-03	0.01	0.01	0.02	0.01	4.9e-02	2.7e-02	7.2e-03	5.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	5.0	16.1	22.9	-4.8	-3.9	-4.6	4.5	3.8	-1.5
BMI without tail	1.3	2.8	5.4	-2.3	-1.3	-2.1	1.9	1.2	0.5
Body weight	0.9	3.7	5.2	-2.3	-1.9	-2.2	2.1	1.8	-0.8
Epididymis fat weight	0.2	0.6	1.0	0.6	1.0	0.7	-0.7	-1.0	0.1
Glucose	0.9	1.4	2.2	-1.5	-1.1	-1.4	1.3	1.1	-0.4
Heart weight	0.6	0.8	1.2	0.6	1.1	0.8	-0.8	-1.1	0.9
Left kidney weight	0.1	0.2	0.8	0.3	-0.2	0.1	-0.1	0.3	-0.9
Right kidney weight	1.0	3.0	4.3	2.1	1.7	2.0	-1.9	-1.6	0.2
Tail length	3.0	8.9	10.8	3.2	3.3	3.3	-3.3	-3.1	1.4
Length with tail	1.4	5.0	7.7	2.8	2.2	2.7	-2.6	-2.1	0.4
Length without tail	0.1	0.2	0.4	0.4	-0.5	0.1	0.0	0.5	-0.6
Liver weight, left	1.8	2.9	4.5	-2.1	-1.5	-2.0	1.9	1.4	-0.9
Liver weight, right	1.7	2.8	3.2	-1.8	-1.6	-1.8	1.8	1.6	-1.5
Parametrial fat weight	0.5	1.0	1.3	0.9	1.1	1.0	-1.0	-1.0	0.6
Retroperitoneal fat weight	0.2	0.7	1.1	-1.1	-0.8	-1.0	1.0	0.7	-0.3
Intraocular pressure	0.6	0.9	2.6	0.0	1.1	0.4	-0.5	-1.1	1.6
Extensor digitorum longus weight	2.9	11.8	19.9	-4.5	-3.1	-4.1	3.9	3.0	0.3
Soleus weight	7.3	21.2	28.8	-5.4	-4.8	-5.3	5.2	4.5	-0.6
Tibialis anterior weight	0.9	3.0	4.3	-2.1	-1.7	-2.0	1.9	1.8	-0.2
Tibia length	0.8	2.3	2.9	1.7	1.6	1.7	-1.7	-1.6	0.8
Number of licking bursts	0.2	0.3	0.9	-0.1	0.6	0.1	-0.2	-0.6	1.0
Food consumed during 24 hour testing period	0.3	0.4	0.6	-0.8	-0.6	-0.8	0.7	0.6	0.2
Times rat made contact with spout	0.2	0.3	1.2	-0.5	0.0	-0.3	0.3	-0.1	1.1
Mean time between licks in bursts	3.9	5.4	6.7	2.5	2.6	2.6	-2.6	-2.5	0.6
Mean num. licks in bursts	0.1	0.1	0.2	-0.2	-0.5	-0.3	0.3	0.4	0.2
Std. dev. time between licks in bursts	0.4	0.5	1.0	1.0	0.3	0.9	-0.8	-0.4	0.5
Water consumed over 24 hours	0.8	1.0	1.6	-0.8	-1.3	-0.9	1.0	1.2	-0.3
Indifference point 0 sec	0.2	0.3	0.4	-0.4	-0.6	-0.5	0.6	0.6	-0.6
Indifference point AUC	1.0	1.2	1.7	1.1	1.3	1.1	-1.2	-1.2	-0.6
Indifference point function ln k	0.5	0.7	2.9	-0.6	-0.6	-0.6	0.6	0.5	1.7
Indifference point function log k	0.5	0.7	2.9	-0.6	-0.6	-0.6	0.6	0.5	1.7
Delay discounting total patch changes 0 sec	0.1	0.2	0.2	-0.4	-0.5	-0.4	0.5	0.4	-0.4
Delay discounting total patch changes 12 sec	0.2	0.2	0.5	-0.6	0.1	-0.5	0.4	-0.0	-0.7
Delay discounting total patch changes 18 sec	1.0	1.3	1.6	1.2	1.2	1.2	-1.2	-1.2	-0.6
Delay discounting total patch changes 24 sec	0.2	0.3	1.1	0.3	0.3	0.3	-0.3	-0.3	-1.1
Delay discounting total patch changes 6 sec	0.2	0.3	0.6	0.6	0.5	0.6	-0.5	-0.4	-0.8
Delay discounting time to switch 0 sec	3.2	4.9	11.3	-1.5	-2.2	-1.7	1.9	2.1	-3.4
Delay discounting water rate 0 sec	1.5	2.4	11.2	0.1	1.1	0.4	-0.6	-1.0	3.4
Delay discounting water rate 12 sec	0.8	1.2	4.6	-1.2	-0.1	-0.9	0.7	0.1	2.1
Delay discounting water rate 18 sec	2.7	3.6	13.6	0.2	1.9	0.7	-1.0	-1.8	3.7
Delay discounting water rate 24 sec	1.7	2.4	11.8	-0.6	1.1	-0.1	-0.1	-1.0	3.4
Delay discounting water rate 6 sec	2.0	2.9	9.5	0.6	1.6	1.0	-1.1	-1.6	3.1
Locomotor activity	2.1	3.3	6.0	2.5	1.5	2.2	-2.1	-1.3	-0.7
Locomotor testing distance	1.3	2.2	3.8	2.0	1.3	1.8	-1.7	-1.2	-0.1
Locomotor testing rearing	0.3	0.5	2.3	0.2	0.5	0.3	-0.3	-0.5	1.5
Light reinforcement 1	4.3	7.9	11.5	3.4	2.8	3.3	-3.2	-2.6	-1.0
Light reinforcement 2	1.3	1.8	2.9	1.7	1.2	1.6	-1.5	-1.2	-0.3
Reaction time number correct	0.8	1.1	5.0	-0.9	-0.0	-0.6	0.5	-0.1	2.2
Reaction time mean minus median	1.2	1.5	3.9	1.0	1.0	1.0	-1.1	-0.9	2.0
Reaction time mean minus median AUC	0.1	0.2	0.4	0.1	-0.6	-0.1	0.2	0.7	0.4
Reaction time num false alarms	0.8	1.1	6.7	-0.3	0.2	-0.1	0.0	-0.2	2.6
Reaction time num false alarms AUC	0.8	1.1	6.4	-0.4	0.3	-0.2	0.0	-0.3	2.5
Reaction time trials correct on left	0.8	1.1	5.0	-0.9	-0.0	-0.6	0.5	-0.1	2.2
Reaction time trials on left	0.7	1.0	4.5	-0.9	-0.1	-0.7	0.5	-0.0	2.1
Reaction time mean	0.1	0.1	0.2	-0.0	-0.5	-0.1	0.2	0.5	0.0
Reaction time mean AUC	0.1	0.1	0.4	-0.1	-0.6	-0.2	0.3	0.6	-0.0
Median of all reaction times	0.5	0.7	1.0	-0.5	-1.0	-0.7	0.8	1.0	-0.8
Reaction time omissions	0.2	0.3	0.4	0.6	0.4	0.6	-0.6	-0.3	-0.7
Reaction time false alarm rate	0.1	0.1	0.8	-0.1	-0.1	-0.1	0.1	0.1	0.9
Reaction time premature initiation rate	1.4	1.9	2.4	1.2	1.6	1.3	-1.3	-1.5	1.2
Reaction time premature initiations	1.8	2.5	6.4	0.8	1.6	1.1	-1.2	-1.7	2.5
Std. dev. reaction times	0.3	0.5	1.7	0.6	0.4	0.5	-0.5	-0.3	1.3
Reaction time trials completed	0.7	1.0	4.5	-0.9	-0.1	-0.7	0.5	-0.0	2.1
Reaction time trials AUC	0.8	1.2	5.7	-0.8	0.1	-0.6	0.4	-0.2	2.4
Social response proportion	0.5	0.6	1.8	0.8	0.4	0.7	-0.6	-0.4	-1.3
Social responses	4.7	6.0	9.8	3.1	2.3	2.9	-2.8	-2.2	-0.1
Social time	1.0	1.3	4.4	-0.9	-0.7	-0.9	0.9	0.7	-2.1
Conditioned locomotion	0.9	1.1	1.9	-1.4	-0.5	-1.2	1.1	0.4	1.3
Cocaine response after cond. corrected	3.5	3.9	6.2	-2.5	-1.4	-2.2	2.0	1.3	2.2
Cocaine response after cond. not corrected	3.6	4.0	6.5	-2.6	-1.4	-2.2	2.1	1.2	2.2
Cocaine response before conditioning	0.2	0.3	0.6	0.8	0.4	0.7	-0.6	-0.4	0.1
Saline control response	0.0	0.0	0.2	-0.2	-0.0	-0.2	0.2	-0.0	-0.4
Condit. Reinf. active minus inactive responses	3.1	3.8	4.5	1.7	2.1	1.9	-2.0	-2.0	1.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.3	0.3	1.1	0.5	-0.7	-1.1	0.9
Condit. Reinf. active responses	2.6	3.6	4.8	1.8	1.8	1.9	-1.9	-1.7	2.2
Condit. Reinf. inactive responses	1.3	1.6	4.4	1.3	0.8	1.2	-1.1	-0.8	2.1
Condit. Reinf. lever presses	2.7	3.7	4.4	1.8	2.1	1.9	-2.0	-2.0	1.7
Condit. Reinf. lever reinforcers received	2.4	3.4	6.5	1.6	1.7	1.7	-1.7	-1.7	2.5
Pavlov. Cond. lever latency	1.0	1.3	2.9	-1.1	-0.9	-1.1	1.0	0.9	-1.7
Pavlov. Cond. magazine entry latency	0.4	0.4	0.6	0.8	0.6	0.7	-0.7	-0.5	0.6
Pavlov. Cond. change in total contacts	1.1	1.5	3.4	1.1	1.0	1.1	-1.1	-1.0	1.8
Pavlov. Cond. index score	1.0	1.3	2.0	1.1	1.0	1.1	-1.1	-1.0	1.4
Pavlov. Cond. latency score	0.8	1.0	1.4	1.1	0.8	1.0	-1.0	-0.8	1.2
Pavlov. Cond. lever contacts	1.2	1.7	4.1	1.0	1.1	1.1	-1.1	-1.1	2.0
Pavlov. Cond. magazine entry number	0.6	0.8	1.0	-1.0	-0.8	-1.0	1.0	0.7	-0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.8	-0.6	-0.1	-0.5	0.4	0.1	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.4	1.1	0.9	1.1	-1.1	-0.9	1.2
Pavlov. Cond. response bias	2.2	3.0	4.3	1.6	1.7	1.7	-1.7	-1.6	2.1
Conditioned reinforcement - actives	2.2	2.1	2.8	1.7	1.6	1.7	-1.7	-1.4	-0.0
Conditioned reinforcement - inactives	0.3	0.4	0.7	-0.8	-0.3	-0.6	0.6	0.3	0.9
Conditioned locomotion	6.7	8.1	10.5	3.2	3.1	3.2	-3.2	-2.8	0.6
Intermittent access intake day 1-15 change	6.5	6.4	8.0	2.7	2.8	2.8	-2.8	-2.6	0.8
Intermittent access intake escalation	7.6	7.5	10.3	2.6	3.2	2.9	-2.9	-3.0	1.3
Intermittent access intake escalation 2	8.9	8.8	12.0	2.9	3.5	3.1	-3.2	-3.3	1.4
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.4	0.5	1.2	0.7	-0.9	-1.0	0.8
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	0.7	0.9	0.8	-0.8	-0.9	0.8
Intermitt. access escalation Index	1.0	0.9	2.3	-0.4	-1.0	-0.6	0.7	1.0	-1.5
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.2	-0.4	-0.3	0.3	0.3	0.3
Intermittent access day 15 total infusions	2.3	2.5	3.1	1.5	1.8	1.7	-1.7	-1.7	1.1
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.5	1.2	1.2	1.2	-1.2	-1.2	0.5
Intermittent access total infusions	0.3	0.3	0.4	0.5	0.6	0.6	-0.6	-0.6	0.5
Intermittent access day 1 locomotion	0.4	0.5	0.7	0.6	0.6	0.6	-0.6	-0.7	0.8
Intermittent access day 15 total locomotion	3.5	3.7	4.7	2.1	2.2	2.1	-2.2	-2.0	0.5
Intermittent access total locomotion	0.9	1.1	1.4	1.2	1.1	1.2	-1.2	-1.0	-0.0
Intermittent access standard deviation	3.6	3.8	4.9	1.9	2.2	2.0	-2.1	-2.0	1.5
Cocaine induced anxiety	0.7	0.8	2.8	0.9	0.3	0.7	-0.6	-0.1	-1.7
Post-drug Anxiety	0.1	0.1	0.4	0.6	-0.2	0.4	-0.3	0.2	-0.4
Baseline Anxiety	0.7	0.7	3.5	0.2	0.4	0.3	-0.3	-0.6	1.9
Lifetime Intake	0.1	0.1	0.2	0.3	0.4	0.3	-0.3	-0.4	0.4
Incentive Sensitization - Responses	0.6	0.5	1.1	0.5	1.1	0.6	-0.8	-0.9	0.4
Incentive Sensitization - Breakpoint	0.6	0.6	1.1	0.5	1.0	0.7	-0.8	-0.9	0.4
Progressive ratio test 1 active lever presses	0.2	0.2	0.9	-0.3	-0.1	-0.2	0.2	-0.0	1.0
Progressive ratio test 1 breakpoint	0.2	0.2	0.8	-0.4	-0.2	-0.4	0.3	0.1	0.9
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.1	0.0	0.1	-0.1	-0.0	0.4
Progressive ratio test 2 active lever presses	0.5	0.6	0.9	0.5	0.9	0.6	-0.7	-0.8	1.0
Progressive ratio test 2 breakpoint	0.4	0.4	0.6	0.6	0.7	0.6	-0.7	-0.6	0.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	0.3	0.2	0.2	-0.2	-0.1	-0.2
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	-0.2	-0.1	0.1	0.3	-0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.2	0.2	0.2	-0.2	-0.2	-0.4
Short access day 10 total inactive lever presses	0.2	0.2	0.5	0.2	0.7	0.3	-0.4	-0.5	-0.2
Short access day 1 total infusions	0.1	0.1	0.4	0.4	-0.2	0.2	-0.1	0.1	-0.6
Short access day 10 total infusions	0.3	0.3	1.8	0.1	0.3	0.2	-0.2	-0.3	1.3
Short access total infusions	0.0	0.0	0.0	0.0	-0.1	-0.0	0.0	0.1	0.1
Short access day 1 locomotion	0.6	0.6	1.2	1.1	0.6	1.0	-0.9	-0.5	0.1
Short access day 10 total locomotion	4.4	4.8	6.0	2.3	2.4	2.4	-2.4	-2.3	1.0
Short access total locomotion	0.8	0.8	1.2	1.1	0.9	1.0	-1.0	-0.8	0.2
Compulsive drug intake	1.4	1.3	1.7	-1.1	-1.3	-1.2	1.2	1.3	-0.9
One hour access (0.3 mA shock)	0.2	0.3	0.8	-0.4	-0.4	-0.4	0.4	0.4	0.9
One hour access (shock baseline)	0.5	0.6	2.5	0.3	0.5	0.4	-0.4	-0.6	1.6
Number of responses in last shaping day	0.2	0.2	0.2	0.4	0.4	0.4	-0.4	-0.4	0.4
Context. condit. distance diff. score	0.2	0.3	0.4	-0.6	-0.4	-0.6	0.5	0.4	0.5
Locomotion velocity, session 1	0.3	0.3	0.6	0.8	-0.0	0.6	-0.5	0.1	-0.8
Locomotion distance, session 1	1.5	1.9	10.3	0.3	-0.7	-0.0	0.1	0.8	-3.2
Locomotion velocity, session 2	1.8	2.1	4.2	2.0	0.8	1.7	-1.5	-0.7	-1.5
Locomotion distance, session 2	1.6	2.3	9.7	1.5	0.2	1.1	-0.9	-0.1	-3.1
Locomotion velocity, session 3	5.6	6.4	7.5	2.7	2.5	2.7	-2.7	-2.4	2.0
Locomotion distance, session 3	0.1	0.1	0.6	-0.0	0.1	0.0	-0.1	-0.1	0.8
Stereotopy head waving bouts, day 3	3.1	3.7	6.0	2.5	1.8	2.3	-2.2	-1.7	-0.2
Stereotopy head waving duration, day 3	4.0	4.8	7.2	2.7	2.1	2.6	-2.5	-2.1	0.6
Locomotion velocity, session 7	1.0	1.1	3.6	0.9	0.6	0.9	-0.8	-0.6	1.9
Locomotion distance, session 7	0.4	0.5	2.5	-0.3	0.3	-0.1	0.0	-0.2	1.6
Stereotopy head waving bouts, day 7	0.2	0.3	0.5	0.1	-0.7	-0.2	0.3	0.7	-0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.5	-0.4	0.2	-0.1	0.4	-0.8
Locomotion velocity, session 8	0.5	0.6	2.4	0.7	-0.4	0.4	-0.2	0.4	-1.5
Locomotion distance, session 8	0.2	0.4	2.0	0.4	-0.0	0.2	-0.2	0.1	-1.4
Degree of sensitization distance	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	0.6	-0.2
Degree of sensitization stereotypy	2.2	2.4	3.5	-1.4	-1.9	-1.6	1.6	1.8	-0.7
Condit. Reinf. active minus inactive responses	3.3	3.7	5.0	2.2	2.0	2.2	-2.2	-1.8	0.8
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.1	1.5	1.8	1.6	-1.7	-1.7	1.7
Condit. Reinf. active responses	2.3	2.8	4.8	2.2	1.5	2.0	-1.9	-1.3	-0.8
Condit. Reinf. inactive responses	0.9	1.1	4.4	1.0	0.2	0.8	-0.6	-0.1	-2.1
Incentive salience index mean	1.3	1.6	2.8	1.7	1.1	1.5	-1.5	-0.9	-0.5
Condit. Reinf. lever presses	1.1	1.5	7.0	0.2	-0.9	-0.2	0.3	1.0	-2.6
Time in familiar zone, hab. session 1	2.8	2.6	4.5	1.4	1.5	1.5	-1.5	-1.6	2.1
Time in novel zone, hab. session 1	1.6	1.5	2.2	-0.9	-1.4	-1.1	1.2	1.5	-1.2
Total zone transitions, hab. session 1	0.7	1.0	3.6	1.1	0.2	0.9	-0.7	-0.1	-1.9
Total locomotion distance, hab. session 1	0.7	1.0	3.7	1.2	-0.3	0.8	-0.6	0.3	-1.9
Locomotion velocity, hab. session 1	1.1	1.6	5.1	1.5	0.2	1.1	-0.9	-0.2	-2.2
Time in familiar zone, hab. session 2	6.9	7.2	8.2	2.6	2.9	2.7	-2.8	-2.8	2.3
Time in novel zone, hab. session 2	5.1	5.2	6.7	-2.2	-2.6	-2.3	2.4	2.5	-1.4
Total zone transitions, hab. session 2	2.5	3.2	14.1	-0.4	-1.4	-0.7	0.9	1.4	-3.8
Total locomotion distance, hab. session 2	1.0	1.3	5.5	1.1	0.1	0.8	-0.6	-0.1	-2.3
Locomotion velocity, hab. session 2	1.3	1.8	8.9	1.0	-0.1	0.7	-0.5	0.1	-3.0
Novel to familiar place preference ratio	5.1	5.3	6.7	-2.0	-2.6	-2.2	2.3	2.6	-2.0
Novelty place preference	3.3	3.5	4.5	-1.6	-2.1	-1.7	1.8	2.1	-1.8
Time in novel zone, NPP test	3.5	3.7	4.7	-1.7	-2.2	-1.9	1.9	2.2	-1.6
Total zone transitions, NPP test	1.4	2.0	11.1	-0.0	-0.6	-0.2	0.3	0.7	-3.3
Total locomotion distance, NPP test	1.1	1.6	7.2	-0.1	-0.9	-0.4	0.5	0.9	-2.7
Locomotion velocity, NPP test	1.0	1.4	7.6	0.2	-0.6	-0.1	0.2	0.6	-2.7
Pavlov. Cond. lever latency	0.4	0.5	1.8	0.1	0.8	0.3	-0.4	-0.8	1.3
Pavlov. Cond. magazine entry latency	2.5	3.2	4.0	2.0	1.9	2.0	-2.0	-1.9	0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.2	0.1	0.2	-0.2	-0.1	-0.5
Pavlov. Cond. index score	0.2	0.2	0.5	0.7	0.2	0.6	-0.5	-0.2	-0.6
Pavlov. Cond. latency score	0.2	0.3	0.9	0.7	-0.0	0.5	-0.4	0.1	-1.0
Pavlov. Cond. lever contacts	0.5	0.5	2.1	0.2	-0.7	-0.1	0.2	0.7	-1.5
Pavlov. Cond. magazine entry number	0.5	0.6	0.9	-0.9	-0.8	-0.9	0.9	0.8	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	0.3	0.9	0.5	-0.6	-0.9	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	1.0	0.5	0.8	-0.8	-0.4	-0.4
Pavlov. Cond. response bias	0.8	1.0	1.4	1.2	1.0	1.1	-1.1	-1.0	0.1
Bone: apparent density	1.0	1.7	5.3	-0.0	-1.4	-0.4	0.6	1.4	-2.3
Bone surface	1.3	2.3	8.4	0.6	-1.5	-0.0	0.3	1.6	-2.9
Bone volume	1.2	2.0	6.9	0.6	-1.5	-0.0	0.3	1.6	-2.6
Bone: connectivity density	1.0	1.5	2.7	-0.5	-1.5	-0.8	0.9	1.5	-1.6
Bone: cortical apparent density	0.6	0.8	1.1	-1.0	-0.9	-1.0	1.0	0.8	-0.4
Bone: cortical area	0.8	1.3	2.2	-0.8	-1.5	-1.0	1.1	1.5	-0.4
Bone: cortical porosity	0.3	0.3	0.6	0.8	0.3	0.7	-0.6	-0.3	-0.7
Bone: cortical porosity	0.4	0.4	2.0	0.2	-0.6	-0.1	0.2	0.6	-1.4
Bone: cortical thickness	1.2	1.9	2.5	-1.3	-1.6	-1.4	1.5	1.5	-0.8
Bone: cortical thickness	0.6	0.7	3.3	0.0	0.6	0.2	-0.3	-0.6	1.8
Bone: cortical tissue density	0.4	0.5	0.7	-0.8	-0.7	-0.8	0.8	0.7	-0.3
Bone: elastic displacement	0.2	0.2	0.3	0.6	0.4	0.5	-0.5	-0.4	-0.2
Bone: elastic work	0.3	0.3	0.7	-0.5	-0.8	-0.6	0.6	0.7	0.1
Bone: endosteal estimation	0.3	0.6	1.0	-0.6	-1.0	-0.7	0.8	0.9	-0.1
Bone: endosteal perimeter	0.1	0.2	0.5	0.7	-0.0	0.5	-0.4	0.0	0.3
Bone: final force	1.4	2.3	3.4	-1.4	-1.9	-1.6	1.6	1.8	-0.2
Bone: final moment	1.1	1.8	2.8	-1.2	-1.7	-1.4	1.4	1.7	-0.2
Bone: marrow area	0.3	0.6	1.0	-0.7	-1.0	-0.8	0.8	1.0	-0.1
Bone: maximum diameter	0.3	0.5	1.4	1.2	0.2	0.9	-0.8	-0.2	-0.3
Bone: maximum force	1.3	2.3	3.2	-1.4	-1.8	-1.6	1.6	1.7	0.3
Bone: maximum moment	1.1	1.9	2.7	-1.3	-1.6	-1.4	1.5	1.6	0.3
Bone: minimum diameter	0.1	0.1	0.3	-0.0	-0.6	-0.2	0.3	0.6	-0.1
Bone: periosteal estimation	0.6	1.2	2.2	-0.7	-1.5	-1.0	1.1	1.5	-0.5
Bone: periosteal perimeter	0.1	0.1	0.3	0.3	-0.5	0.1	0.0	0.6	-0.0
Bone: post-yield work	0.5	0.7	0.8	-0.9	-0.7	-0.9	0.8	0.7	0.8
Bone: stiffness	2.9	4.5	5.8	-2.2	-2.4	-2.3	2.4	2.3	-0.2
Bone: tissue strength	1.8	1.7	1.8	-1.3	-1.3	-1.4	1.4	1.3	-1.3
Bone: trabecular number	0.2	0.4	1.0	1.0	-0.1	0.7	-0.6	0.1	-0.6
Bone: trabecular spacing	0.8	1.0	4.4	-0.7	0.7	-0.3	0.1	-0.8	2.1
Bone: trabecular thickness	2.3	2.8	9.4	0.1	-1.8	-0.5	0.7	1.8	-3.1
Bone: trabecular tissue density	1.1	1.5	2.6	-1.6	-1.0	-1.5	1.4	0.9	-0.8
Breakpoint value in progressive ratio session	5.2	5.8	7.5	2.5	2.7	2.7	-2.6	-2.6	0.4
Distance traveled before self-admin	0.5	0.5	1.1	-0.6	-0.6	-0.6	0.5	0.8	-1.0
Distance traveled after self-admin	0.7	0.7	0.9	0.9	0.8	0.9	-0.8	-0.6	-1.0
Delta time in closed arm before/after self-admin	0.6	0.6	2.1	-0.8	0.6	-0.4	0.3	-0.5	1.5
Delta time in open arm before/after self-admin	1.3	1.3	1.7	-1.1	-1.3	-1.2	1.2	1.3	-0.5
Diff in mean of infusions in LGA sessions	1.3	1.5	2.0	1.4	1.3	1.4	-1.3	-1.3	0.3
Extinction: sum of active levers before priming	1.8	1.9	3.2	1.1	1.8	1.3	-1.5	-1.7	-0.1
Active lever presses in extinction session 6	2.6	2.5	3.3	1.8	1.7	1.8	-1.7	-1.5	-0.8
Delta distance traveled before/after self-admin	1.2	1.3	1.9	1.4	1.1	1.3	-1.2	-1.1	-0.1
Delta ambulatory time before/after self-admin	1.1	1.2	2.1	1.4	1.1	1.4	-1.1	-1.1	-0.1
Time in closed arm before self-admin	1.7	1.9	3.0	-0.9	-1.6	-1.1	1.2	1.5	-1.7
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	0.1	0.1	-0.0	-0.2	0.0
Time in open arm before self-admin	1.1	1.2	1.7	1.0	1.3	1.1	-1.2	-1.1	0.4
Time in open arm after self-admin	0.5	0.5	0.8	-0.9	-0.7	-0.9	0.7	0.8	0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.8	0.0	0.1	0.0	-0.0	-0.1	-0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.7	-0.0	0.5	-0.5	0.0	-0.2
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.4	0.2	0.7	0.4	-0.5	-0.9	1.2
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.4	-0.4	0.2	-0.1	0.2	-0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.8	0.5	-0.0	0.3	-0.3	-0.1	0.9
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	-0.7	0.2	-0.4	0.3	-0.3	0.9
Delta time to tail flick, test, before/after SA	0.9	0.8	3.1	0.3	0.7	0.4	-0.5	-0.7	1.8
Ambulatory time before self-admin	0.4	0.4	0.9	-0.5	-0.5	-0.5	0.5	0.6	-1.0
Ambulatory time after self-admin	0.4	0.5	0.8	0.7	0.7	0.7	-0.6	-0.4	-0.9
Total heroin consumption	1.6	1.9	2.5	1.6	1.4	1.6	-1.6	-1.3	0.0
Area under the delay curve	2.2	2.3	3.0	-1.6	-1.7	-1.7	1.6	1.7	-0.1
Delay disc. indifference point, 0s delay	9.5	10.3	12.9	-2.8	-3.6	-3.1	3.2	3.5	-3.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.2	-0.4	-0.5	-0.4	0.4	0.5	0.3
Delay disc. indifference point, 2s delay	5.7	6.4	8.4	-2.6	-2.9	-2.7	2.8	2.7	-0.8
Delay disc. indifference point, 24s delay	0.4	0.4	0.7	-0.8	-0.6	-0.8	0.7	0.6	0.0
Delay disc. indifference point, 4s delay	1.5	1.6	2.6	-1.1	-1.6	-1.2	1.3	1.5	0.7
Delay disc. indifference point, 8s delay	0.7	0.8	1.3	-1.1	-0.8	-1.0	1.0	0.8	0.1
Delay discount exponential model param	1.9	2.0	2.6	1.5	1.6	1.6	-1.5	-1.6	-0.1
Delay discount hyperbolic model param	2.7	2.9	3.7	1.8	1.9	1.9	-1.8	-1.9	-0.0
Fecal boli incidents, locomotor time 1	1.4	1.5	2.9	-1.4	-0.7	-1.3	1.2	0.8	-1.7
Change in fecal boli incidents, locomotor task	0.3	0.3	1.2	0.5	-0.2	0.4	-0.3	0.1	1.1
Time >=10cm from walls, locomotor time 1	1.3	1.3	5.1	-0.5	-0.9	-0.6	0.7	1.0	-2.3
Bouts of movement, locomotor time 1	0.3	0.4	1.0	0.4	0.6	0.5	-0.5	-0.5	1.0
Total resting periods, locomotor time 1	0.3	0.4	0.8	0.5	0.5	0.5	-0.5	-0.5	0.9
Rest time, locomotor task time 1	0.1	0.2	0.2	0.5	0.3	0.4	-0.4	-0.3	0.4
Distance moved, locomotor task time 1	1.1	1.2	2.4	-0.6	-1.3	-0.8	0.9	1.2	-1.5
Vertical activity count, locomotor time 1	0.1	0.2	0.7	-0.3	-0.1	-0.2	0.2	0.1	0.9
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.3	-1.1	-0.5	-1.0	0.9	0.7	-0.3
Bouts of movement, locomotor time 2	0.1	0.2	0.5	0.7	-0.1	0.5	-0.4	0.0	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.6	-0.1	0.4	-0.3	0.1	-0.3
Rest time, locomotor task time 2	0.3	0.3	0.7	0.8	0.3	0.7	-0.6	-0.3	-0.2
Distance moved, locomotor task time 2	0.4	0.4	0.9	-0.9	-0.5	-0.8	0.8	0.5	-0.0
Vertical activity count, locomotor time 2	0.3	0.3	0.8	-0.9	-0.1	-0.7	0.6	0.1	0.7
Weight adjusted by age	0.2	0.2	0.7	-0.6	0.1	-0.4	0.4	-0.2	0.9
Seeking ratio, delayed vs. immediate footshock	3.3	3.8	5.8	2.4	1.9	2.3	-2.3	-1.7	0.3
Locomotion in novel chamber	0.7	0.9	1.4	0.6	1.2	0.8	-0.9	-0.9	-1.2
Locomotion in novel chamber post-restriction	0.9	1.1	1.8	1.0	0.9	1.0	-1.0	-1.0	1.3
Progressive ratio	0.2	0.2	0.6	-0.5	-0.0	-0.4	0.3	0.1	-0.8
Food seeking constrained by brief footshock	0.2	0.3	1.2	0.3	0.3	0.3	-0.3	-0.3	-1.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.5	0.0	0.4	-0.3	-0.1	-0.1
Run reversals in cocaine runway, females	0.3	0.3	0.4	0.7	0.4	0.6	-0.5	-0.3	0.7
Run reversals in cocaine runway, males	0.7	0.7	1.3	1.1	0.7	1.0	-0.9	-0.7	0.4
Latency to leave start box in cocaine runway	0.7	0.8	1.7	1.1	0.3	0.9	-0.8	-0.2	-1.3
Latency to leave start box in cocaine runway, F	1.1	1.2	5.3	0.1	-0.9	-0.2	0.3	1.0	-2.3
Latency to leave start box in cocaine runway, M	3.7	3.5	4.9	1.7	2.2	1.9	-2.0	-2.1	1.3
Cd content in liver	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.5	0.5	-0.4
Co content in liver	0.6	0.7	1.0	0.8	1.0	0.9	-0.9	-0.9	0.2
Cu content in liver	0.4	0.5	1.0	-0.3	-0.9	-0.4	0.5	0.9	-1.0
Fe content in liver	0.1	0.1	0.2	0.1	0.4	0.2	-0.2	-0.5	0.5
K content in liver	0.6	0.6	2.7	0.0	-0.5	-0.2	0.2	0.7	-1.6
Mg content in liver	0.5	0.5	2.0	-0.0	-0.6	-0.2	0.3	0.8	-1.4
Mn content in liver	0.5	0.5	1.1	1.0	-0.4	0.6	-0.4	0.4	-1.0
Na content in liver	1.8	1.9	3.3	-1.0	-1.4	-1.2	1.2	1.4	-1.8
Rb content in liver	1.0	1.2	1.9	-0.6	-1.3	-0.8	0.9	1.3	-1.4
Se content in liver	0.1	0.1	0.2	0.5	0.3	0.4	-0.4	-0.3	-0.1
Sr content in liver	0.3	0.3	0.8	0.0	0.6	0.2	-0.3	-0.7	0.9
Zn content in liver	3.5	3.9	5.9	1.4	2.4	1.7	-1.9	-2.3	2.0