Hub : Genes

Spns2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000057040	0.15	0.09	1.2e-09	0.07	0.06	0.06	0.06	1.5e-08	7.9e-07	4.8e-07	2.6e-07
2	Brain	mRNA stability	ENSRNOG00000057040	0.03	0.02	4.7e-03	0.02	0.02	0.01	0.02	2.7e-03	5.2e-03	2.3e-02	8.8e-03
3	Liver	gene expression	ENSRNOG00000057040	0.02	0.02	5.4e-03	0.01	0.01	0.01	0.01	1.1e-02	1.7e-02	2.2e-02	2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	0.2	0.8	1.2	-0.5	0.9	-1.1
BMI without tail	0.4	0.9	1.5	-0.6	1.0	-1.2
Body weight	0.4	1.7	2.5	0.6	1.5	-1.6
Epididymis fat weight	3.3	7.8	10.3	-1.8	3.1	-3.2
Glucose	0.5	0.8	0.9	-0.9	-0.9	0.9
Heart weight	0.8	1.2	1.4	-0.9	1.2	-1.2
Left kidney weight	0.1	0.3	0.8	-0.9	0.2	-0.2
Right kidney weight	0.1	0.1	0.4	-0.6	0.1	-0.1
Tail length	0.8	2.3	3.4	0.5	1.8	-1.8
Length with tail	0.3	1.2	1.2	1.1	1.1	-1.1
Length without tail	0.4	0.8	1.1	0.6	1.1	-1.0
Liver weight, left	0.2	0.3	0.7	0.8	0.2	-0.2
Liver weight, right	0.7	1.2	1.8	-0.3	1.3	-1.3
Parametrial fat weight	10.7	21.0	28.7	-2.7	5.2	-5.4
Retroperitoneal fat weight	0.2	0.6	1.1	-1.1	0.6	-0.6
Intraocular pressure	1.2	1.6	3.4	-1.8	0.9	-0.8
Extensor digitorum longus weight	3.8	15.3	17.3	-3.4	4.2	-4.1
Soleus weight	2.0	6.0	9.2	-0.4	3.0	-2.9
Tibialis anterior weight	3.6	12.6	16.4	-2.3	4.0	-4.0
Tibia length	0.5	1.5	3.9	2.0	-0.5	0.5
Number of licking bursts	0.2	0.3	0.4	0.3	-0.6	0.6
Food consumed during 24 hour testing period	0.6	0.7	1.3	1.1	-0.6	0.6
Times rat made contact with spout	1.5	1.7	1.8	1.3	-1.3	1.3
Mean time between licks in bursts	1.6	2.3	3.1	-0.7	1.8	-1.8
Mean num. licks in bursts	0.1	0.1	0.2	0.4	-0.1	0.1
Std. dev. time between licks in bursts	0.6	0.7	0.9	-0.5	1.0	-1.0
Water consumed over 24 hours	4.1	4.9	6.6	2.6	-2.0	2.0
Indifference point 0 sec	2.0	3.2	3.6	1.9	-1.7	1.8
Indifference point AUC	1.6	1.9	4.6	-2.1	0.7	-0.8
Indifference point function ln k	5.8	8.2	12.5	3.5	-2.4	2.5
Indifference point function log k	5.8	8.2	12.5	3.5	-2.4	2.5
Delay discounting total patch changes 0 sec	1.4	2.2	2.4	1.5	-1.4	1.5
Delay discounting total patch changes 12 sec	0.8	1.1	2.0	-1.4	0.9	-0.8
Delay discounting total patch changes 18 sec	0.3	0.4	1.0	-1.0	0.4	-0.4
Delay discounting total patch changes 24 sec	0.3	0.4	1.2	-1.1	0.0	-0.0
Delay discounting total patch changes 6 sec	0.9	1.4	3.7	-1.9	0.6	-0.6
Delay discounting time to switch 0 sec	1.6	2.5	2.8	-1.4	1.7	-1.7
Delay discounting water rate 0 sec	0.6	1.0	1.2	0.8	-1.1	1.1
Delay discounting water rate 12 sec	0.4	0.5	0.9	-0.1	0.9	-0.9
Delay discounting water rate 18 sec	0.5	0.7	2.1	1.4	-0.1	0.2
Delay discounting water rate 24 sec	0.1	0.2	0.3	-0.1	0.6	-0.5
Delay discounting water rate 6 sec	0.1	0.1	0.2	0.5	-0.3	0.4
Locomotor activity	0.7	1.2	1.5	-0.9	1.2	-1.1
Locomotor testing distance	3.6	6.0	6.2	-2.5	2.5	-2.4
Locomotor testing rearing	3.8	5.9	7.8	-2.8	2.2	-2.2
Light reinforcement 1	1.5	2.7	2.8	-1.6	1.6	-1.7
Light reinforcement 2	0.1	0.2	0.4	-0.6	0.3	-0.3
Reaction time number correct	0.1	0.2	0.3	0.3	0.5	-0.5
Reaction time mean minus median	0.6	0.8	1.2	0.3	-1.1	1.0
Reaction time mean minus median AUC	0.1	0.2	0.3	0.1	-0.5	0.5
Reaction time num false alarms	1.2	1.7	2.2	0.9	-1.4	1.5
Reaction time num false alarms AUC	0.9	1.2	1.7	0.7	-1.2	1.3
Reaction time trials correct on left	0.1	0.2	0.3	0.3	0.5	-0.5
Reaction time trials on left	0.1	0.2	0.3	0.3	0.5	-0.5
Reaction time mean	0.3	0.4	0.6	0.3	-0.8	0.6
Reaction time mean AUC	0.6	0.8	1.2	0.3	-1.1	1.0
Median of all reaction times	0.1	0.1	0.2	0.1	-0.5	0.3
Reaction time omissions	0.4	0.5	0.6	-0.8	0.6	-0.7
Reaction time false alarm rate	0.8	1.2	1.7	0.5	-1.2	1.3
Reaction time premature initiation rate	1.6	2.1	3.5	1.9	-1.1	1.3
Reaction time premature initiations	1.2	1.6	3.5	1.9	-0.8	0.9
Std. dev. reaction times	1.3	1.8	2.5	0.8	-1.6	1.5
Reaction time trials completed	0.1	0.2	0.3	0.3	0.5	-0.5
Reaction time trials AUC	0.1	0.2	0.2	0.3	0.5	-0.4
Social response proportion	1.4	1.5	4.4	2.1	-0.1	0.1
Social responses	1.5	2.0	3.1	-0.4	1.8	-1.6
Social time	1.0	1.3	2.1	-0.0	1.5	-1.3
Conditioned locomotion	0.6	0.7	1.1	0.3	-1.1	1.0
Cocaine response after cond. corrected	0.6	0.7	1.4	1.2	-0.6	0.6
Cocaine response after cond. not corrected	0.3	0.3	0.7	0.9	-0.3	0.3
Cocaine response before conditioning	0.8	1.0	1.1	-0.9	1.0	-1.0
Saline control response	0.5	0.6	0.7	-0.7	0.8	-0.8
Condit. Reinf. active minus inactive responses	0.6	0.7	1.3	1.2	-0.6	0.6
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.3	1.2	-0.9	1.0
Condit. Reinf. active responses	0.2	0.3	0.6	0.8	-0.3	0.4
Condit. Reinf. inactive responses	0.1	0.2	0.2	-0.5	0.4	-0.3
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.0	-0.7	0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	0.6	-0.3	0.4
Pavlov. Cond. lever latency	1.5	2.0	2.9	-0.6	1.7	-1.7
Pavlov. Cond. magazine entry latency	1.0	1.1	1.4	0.8	-1.2	1.2
Pavlov. Cond. change in total contacts	0.8	1.1	1.4	0.7	-1.2	1.2
Pavlov. Cond. index score	0.8	1.1	1.6	0.1	-1.3	1.3
Pavlov. Cond. latency score	0.9	1.2	1.8	0.0	-1.3	1.3
Pavlov. Cond. lever contacts	0.4	0.6	0.9	0.2	-0.9	0.9
Pavlov. Cond. magazine entry number	0.6	0.7	1.1	-0.4	1.0	-1.0
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.6	-0.7	1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.7	0.2	-1.3	1.3
Pavlov. Cond. response bias	0.8	1.1	1.5	0.5	-1.2	1.2
Conditioned reinforcement - actives	1.2	1.1	1.4	-0.9	1.2	-1.2
Conditioned reinforcement - inactives	2.0	2.3	2.8	-1.7	1.4	-1.5
Conditioned locomotion	0.6	0.8	1.8	-1.3	0.5	-0.5
Intermittent access intake day 1-15 change	1.2	1.2	3.1	-1.8	0.5	-0.5
Intermittent access intake escalation	1.0	1.0	2.8	-1.7	0.3	-0.4
Intermittent access intake escalation 2	0.3	0.3	0.8	-0.9	-0.3	0.3
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.2	-0.5	-0.4	0.3
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.5	-0.3	0.3
Intermitt. access escalation Index	0.4	0.4	0.6	0.3	0.8	-0.7
Intermittent access day 1 total infusions	2.3	2.6	2.9	-1.5	1.7	-1.7
Intermittent access day 15 total infusions	5.5	6.2	9.6	-3.1	2.1	-2.1
Intermittent access terminal intake (last 3 days)	4.6	5.0	5.5	-2.3	2.2	-2.2
Intermittent access total infusions	3.3	3.6	4.4	-2.1	1.8	-1.8
Intermittent access day 1 locomotion	3.1	3.1	3.2	-1.8	1.8	-1.8
Intermittent access day 15 total locomotion	1.8	1.9	3.3	-1.8	1.1	-1.2
Intermittent access total locomotion	1.6	1.7	1.9	-1.4	1.3	-1.3
Intermittent access standard deviation	4.3	4.6	9.3	-3.0	1.5	-1.5
Cocaine induced anxiety	1.8	2.1	2.4	1.2	-1.5	1.5
Post-drug Anxiety	0.9	1.0	1.2	1.1	-0.9	0.9
Baseline Anxiety	0.6	0.6	0.8	-0.6	0.9	-0.8
Lifetime Intake	4.8	5.4	6.4	-2.5	2.2	-2.2
Incentive Sensitization - Responses	0.2	0.2	0.3	-0.2	0.5	-0.6
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.2	0.5	-0.5
Progressive ratio test 1 active lever presses	1.5	1.6	1.9	-1.0	1.4	-1.4
Progressive ratio test 1 breakpoint	1.9	2.0	2.6	-0.9	1.6	-1.6
Progressive ratio test 1 inactive lever presses	2.1	2.2	2.7	-1.6	1.4	-1.5
Progressive ratio test 2 active lever presses	1.0	1.1	1.3	-0.8	1.1	-1.1
Progressive ratio test 2 breakpoint	0.6	0.7	0.9	-0.6	0.9	-0.9
Progressive ratio test 2 inactive lever presses	2.7	3.2	3.2	-1.8	1.7	-1.8
Total sessions with >9 infusions	3.2	3.5	3.8	-2.0	1.9	-1.8
Short access day 1 total inactive lever presses	0.3	0.3	0.5	-0.7	0.4	-0.5
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.5	-0.2	0.2
Short access day 1 total infusions	4.1	4.3	8.1	-2.8	1.6	-1.5
Short access day 10 total infusions	2.0	2.2	2.2	-1.4	1.5	-1.5
Short access total infusions	4.9	5.4	7.7	-2.8	2.1	-2.0
Short access day 1 locomotion	1.3	1.3	2.8	-1.7	0.8	-0.8
Short access day 10 total locomotion	1.1	1.2	1.9	-1.4	0.9	-0.9
Short access total locomotion	1.1	1.2	2.0	-1.4	0.9	-0.8
Compulsive drug intake	1.2	1.2	2.0	1.4	-0.9	0.9
One hour access (0.3 mA shock)	1.9	2.2	2.3	-1.5	1.4	-1.5
One hour access (shock baseline)	3.0	3.5	4.0	-2.0	1.8	-1.8
Number of responses in last shaping day	0.7	0.7	2.0	-1.4	0.3	-0.4
Context. condit. distance diff. score	1.1	1.3	1.9	-0.5	1.4	-1.4
Locomotion velocity, session 1	1.5	1.6	2.5	-0.2	1.6	-1.5
Locomotion distance, session 1	0.9	1.1	1.2	-0.9	1.1	-1.1
Locomotion velocity, session 2	0.3	0.4	1.0	1.0	-0.3	0.3
Locomotion distance, session 2	0.1	0.2	0.3	0.2	0.5	-0.6
Locomotion velocity, session 3	2.0	2.3	3.1	1.0	-1.7	1.8
Locomotion distance, session 3	0.1	0.1	0.1	0.4	-0.4	0.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.2	-0.0	0.0
Stereotopy head waving duration, day 3	0.3	0.4	1.2	-1.1	-0.0	0.1
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	0.2	-0.3
Locomotion distance, session 7	0.0	0.0	0.0	0.2	-0.0	-0.0
Stereotopy head waving bouts, day 7	1.1	1.2	1.6	-0.7	1.3	-1.2
Stereotopy head waving duration, day 7	1.2	1.5	2.0	-0.8	1.4	-1.3
Locomotion velocity, session 8	1.2	1.4	1.8	-0.8	1.3	-1.4
Locomotion distance, session 8	1.3	2.0	3.1	-0.2	1.7	-1.7
Degree of sensitization distance	0.7	0.7	0.9	-0.6	0.9	-0.9
Degree of sensitization stereotypy	1.0	1.1	1.7	-0.3	1.3	-1.3
Condit. Reinf. active minus inactive responses	1.2	1.3	2.1	1.4	-0.9	1.0
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.2	1.1	-0.8	0.8
Condit. Reinf. active responses	0.8	1.0	1.7	1.3	-0.8	0.8
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.2	0.1
Incentive salience index mean	1.5	1.8	3.4	1.8	-1.0	1.0
Condit. Reinf. lever presses	1.6	2.2	5.2	2.3	-0.8	0.8
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.6	0.1	-0.1
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.8	-0.3	0.3
Total zone transitions, hab. session 1	5.0	7.1	7.9	-2.8	2.6	-2.6
Total locomotion distance, hab. session 1	0.3	0.5	0.6	-0.6	0.7	-0.8
Locomotion velocity, hab. session 1	0.4	0.6	0.6	-0.8	0.8	-0.8
Time in familiar zone, hab. session 2	0.2	0.2	0.4	0.6	-0.2	0.3
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.1	-0.6	0.5
Total zone transitions, hab. session 2	2.5	3.2	3.6	-1.6	1.9	-1.9
Total locomotion distance, hab. session 2	0.4	0.5	0.6	-0.7	0.8	-0.8
Locomotion velocity, hab. session 2	0.5	0.6	0.7	-0.8	0.8	-0.8
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.4	0.0	-0.1
Novelty place preference	0.0	0.0	0.0	-0.1	0.0	-0.1
Time in novel zone, NPP test	0.0	0.0	0.0	0.1	0.1	-0.1
Total zone transitions, NPP test	3.2	4.6	4.7	-2.2	2.1	-2.1
Total locomotion distance, NPP test	0.3	0.4	0.9	-0.9	0.3	-0.3
Locomotion velocity, NPP test	0.2	0.3	0.9	-1.0	-0.0	0.0
Pavlov. Cond. lever latency	2.5	3.2	4.0	-2.0	1.6	-1.7
Pavlov. Cond. magazine entry latency	3.6	4.6	7.2	2.7	-1.8	1.8
Pavlov. Cond. change in total contacts	2.8	2.9	3.3	1.5	-1.8	1.8
Pavlov. Cond. index score	2.4	3.1	5.1	2.3	-1.4	1.5
Pavlov. Cond. latency score	2.6	3.3	5.9	2.4	-1.4	1.4
Pavlov. Cond. lever contacts	1.8	2.1	3.0	1.7	-1.3	1.3
Pavlov. Cond. magazine entry number	2.0	2.5	3.3	-1.8	1.4	-1.5
Pavlov. Cond. intertrial magazine entries	3.4	4.0	5.2	-2.3	1.8	-1.9
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	4.5	2.1	-1.4	1.5
Pavlov. Cond. response bias	2.4	2.9	4.0	2.0	-1.5	1.5
Bone: apparent density	0.3	0.5	0.5	0.7	0.7	-0.7
Bone surface	1.0	1.7	2.4	-0.6	1.5	-1.5
Bone volume	1.4	2.4	3.2	-0.9	1.8	-1.8
Bone: connectivity density	0.6	1.0	1.4	0.2	1.2	-1.2
Bone: cortical apparent density	1.2	1.5	2.1	0.7	-1.4	1.4
Bone: cortical area	0.1	0.2	0.2	-0.5	-0.4	0.4
Bone: cortical porosity	1.7	1.8	3.4	1.8	-1.0	1.0
Bone: cortical porosity	1.6	1.8	2.9	1.7	-1.1	1.1
Bone: cortical thickness	2.2	3.6	4.6	1.3	-2.1	2.1
Bone: cortical thickness	4.4	5.1	6.0	2.4	-2.2	2.2
Bone: cortical tissue density	1.0	1.3	1.7	0.7	-1.3	1.3
Bone: elastic displacement	0.3	0.3	0.4	-0.2	-0.6	0.7
Bone: elastic work	1.2	1.6	2.4	0.5	-1.5	1.5
Bone: endosteal estimation	3.2	6.8	9.5	-3.1	2.3	-2.3
Bone: endosteal perimeter	3.4	7.0	9.0	-3.0	2.4	-2.5
Bone: final force	0.6	1.0	1.0	-1.0	1.0	-1.0
Bone: final moment	0.6	1.0	1.3	-1.1	1.0	-0.9
Bone: marrow area	3.1	6.7	9.3	-3.1	2.3	-2.3
Bone: maximum diameter	0.7	1.2	2.7	-1.6	0.7	-0.7
Bone: maximum force	0.7	1.1	1.4	-1.2	1.0	-1.0
Bone: maximum moment	0.8	1.3	1.9	-1.4	1.0	-1.0
Bone: minimum diameter	2.1	3.9	4.8	-2.2	1.9	-1.9
Bone: periosteal estimation	1.4	2.9	4.9	-2.2	1.4	-1.4
Bone: periosteal perimeter	0.9	1.5	2.6	-1.6	1.0	-1.0
Bone: post-yield work	0.4	0.6	0.9	-0.0	0.9	-0.9
Bone: stiffness	1.9	3.0	4.3	-0.7	2.0	-2.1
Bone: tissue strength	0.1	0.1	0.3	-0.5	-0.1	0.1
Bone: trabecular number	0.3	0.4	1.1	1.1	0.1	-0.1
Bone: trabecular spacing	0.2	0.2	0.7	-0.8	0.1	-0.1
Bone: trabecular thickness	0.1	0.1	0.2	0.1	0.5	-0.4
Bone: trabecular tissue density	1.7	2.4	3.5	0.6	-1.9	1.8
Breakpoint value in progressive ratio session	0.2	0.2	0.4	0.1	0.5	-0.6
Distance traveled before self-admin	0.4	0.5	1.3	-1.2	0.2	-0.2
Distance traveled after self-admin	7.0	7.7	9.2	-3.0	2.6	-2.6
Delta time in closed arm before/after self-admin	0.8	0.8	1.5	-1.2	0.7	-0.6
Delta time in open arm before/after self-admin	0.9	0.9	1.2	-0.6	1.0	-1.1
Diff in mean of infusions in LGA sessions	0.4	0.4	1.2	1.1	-0.2	0.1
Extinction: sum of active levers before priming	0.9	0.9	1.5	-0.0	1.2	-1.2
Active lever presses in extinction session 6	1.0	1.0	1.3	-0.7	1.1	-1.1
Delta distance traveled before/after self-admin	4.2	4.5	5.8	-1.6	2.3	-2.4
Delta ambulatory time before/after self-admin	2.8	3.1	3.9	-1.2	2.0	-2.0
Time in closed arm before self-admin	0.5	0.6	1.6	1.3	-0.3	0.3
Time in closed arm after self-admin	0.0	0.0	0.1	-0.0	-0.2	0.3
Time in open arm before self-admin	0.9	1.0	1.5	-0.1	-1.2	1.2
Time in open arm after self-admin	0.6	0.6	1.6	-1.3	0.3	-0.5
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	0.9	0.3	-0.4
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.8	0.1	-0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.4	0.4	-0.3
Time to tail flick, test, before self-admin	3.9	3.8	5.6	2.4	-1.7	1.7
Time to tail flick, test, after self-admin	0.8	0.8	1.4	1.2	-0.6	0.8
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	2.1	-1.5	0.6	-0.4
Delta time to tail flick, test, before/after SA	1.7	1.5	2.2	-1.5	1.1	-1.1
Ambulatory time before self-admin	0.2	0.2	0.5	-0.7	-0.2	0.1
Ambulatory time after self-admin	3.5	3.8	4.4	-1.7	2.1	-2.1
Total heroin consumption	0.6	0.7	1.4	1.2	0.6	-0.6
Area under the delay curve	0.0	0.1	0.1	-0.4	-0.1	0.1
Delay disc. indifference point, 0s delay	2.2	2.4	2.4	-1.5	1.5	-1.5
Delay disc. indifference point, 16s delay	0.4	0.5	1.0	-1.0	0.4	-0.4
Delay disc. indifference point, 2s delay	0.1	0.2	0.2	0.2	-0.5	0.5
Delay disc. indifference point, 24s delay	1.0	1.0	1.1	0.8	-1.0	1.0
Delay disc. indifference point, 4s delay	0.5	0.5	0.6	-0.8	0.7	-0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.0	-0.0
Delay discount exponential model param	0.1	0.1	0.1	0.0	0.3	-0.3
Delay discount hyperbolic model param	0.0	0.0	0.0	0.1	0.2	-0.2
Fecal boli incidents, locomotor time 1	0.4	0.4	0.5	0.6	-0.6	0.7
Change in fecal boli incidents, locomotor task	0.6	0.6	0.6	0.7	-0.8	0.8
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.5	0.7	-0.7	0.6
Bouts of movement, locomotor time 1	0.7	0.8	1.2	1.1	-0.7	0.8
Total resting periods, locomotor time 1	2.0	2.2	2.7	1.6	-1.4	1.4
Rest time, locomotor task time 1	0.6	0.7	0.9	0.5	-1.0	0.9
Distance moved, locomotor task time 1	1.2	1.3	1.4	-1.1	1.2	-1.2
Vertical activity count, locomotor time 1	1.2	1.3	1.5	-0.9	1.2	-1.2
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.1	0.9	-1.0	0.9
Bouts of movement, locomotor time 2	1.3	1.4	1.5	1.2	-1.2	1.2
Total resting periods, locomotor time 2	0.9	0.9	1.2	1.1	-0.9	0.9
Rest time, locomotor task time 2	1.0	1.2	1.3	1.0	-1.1	1.1
Distance moved, locomotor task time 2	2.0	2.4	3.0	-1.7	1.4	-1.4
Vertical activity count, locomotor time 2	0.7	0.8	0.9	-0.9	0.9	-0.9
Weight adjusted by age	3.0	3.3	3.7	-1.7	1.9	-1.8
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.9	0.4	-1.0	0.9
Locomotion in novel chamber	0.6	0.7	1.9	-1.4	0.2	-0.3
Locomotion in novel chamber post-restriction	0.3	0.4	0.6	0.4	-0.7	0.7
Progressive ratio	0.5	0.6	1.2	-1.1	0.6	-0.5
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.4	-0.5	0.5
Seeking ratio, punishment vs. effort	1.0	1.2	1.9	1.4	-1.0	1.0
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.1	-0.3	0.3
Run reversals in cocaine runway, males	1.9	1.8	3.1	-1.8	1.0	-1.1
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.3	-0.4	0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	0.6	-0.3	0.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	-0.5	0.5	-0.4
Cd content in liver	1.2	1.3	1.8	-0.9	1.2	-1.3
Co content in liver	0.2	0.3	0.4	-0.3	0.6	-0.6
Cu content in liver	3.0	3.6	4.2	2.0	-1.9	1.8
Fe content in liver	0.2	0.2	0.6	0.8	0.2	-0.2
K content in liver	0.1	0.1	0.4	0.6	0.2	-0.2
Mg content in liver	0.0	0.0	0.0	-0.2	-0.1	0.1
Mn content in liver	1.5	1.8	2.6	1.6	-1.2	1.2
Na content in liver	0.1	0.1	0.3	-0.5	-0.1	0.1
Rb content in liver	0.8	1.0	1.1	-1.0	1.0	-1.0
Se content in liver	1.1	1.4	1.8	0.8	-1.3	1.3
Sr content in liver	2.0	1.9	2.2	-1.1	1.5	-1.5
Zn content in liver	0.2	0.2	0.3	0.3	-0.5	0.5