Cited2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000056940	0.04	0.02	7.1e-05	0.02	0.04	0.04	0.03	3.7e-03	4.1e-05	7.2e-05	2.0e-04
2	Liver	gene expression	ENSRNOG00000056940	0.1	0.05	6.1e-11	0.07	0.1	0.11	0.11	1.8e-08	1.9e-11	2.3e-12	3.5e-12
3	NAcc	gene expression	ENSRNOG00000056940	0.13	0.06	3.4e-06	0.1	0.07	0.09	0.09	1.5e-07	7.2e-06	6.3e-07	2.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	0.6	1.9	3.1	0.0	-1.8	1.6
BMI without tail	0.3	0.6	1.1	-0.9	1.1	0.1
Body weight	0.6	2.5	3.8	-1.9	1.6	-1.0
Epididymis fat weight	0.2	0.4	0.6	-0.8	0.4	-0.6
Glucose	0.9	1.4	2.6	-0.0	-1.3	1.6
Heart weight	0.6	0.8	2.1	0.1	0.7	-1.4
Left kidney weight	0.7	1.9	2.8	-1.6	1.7	-0.3
Right kidney weight	2.0	5.8	10.0	-3.2	2.7	-0.4
Tail length	5.4	16.3	29.4	-3.0	5.4	-3.2
Length with tail	2.9	10.7	16.8	-2.7	4.1	-2.9
Length without tail	0.4	0.9	1.2	-1.1	0.8	-0.9
Liver weight, left	0.3	0.5	1.2	-1.1	0.2	0.3
Liver weight, right	0.6	1.1	2.6	-1.6	0.7	-0.3
Parametrial fat weight	0.0	0.0	0.1	-0.1	-0.0	0.2
Retroperitoneal fat weight	0.9	3.0	7.5	-1.0	0.7	-2.7
Intraocular pressure	0.7	1.0	2.4	-1.6	0.8	0.1
Extensor digitorum longus weight	0.9	3.7	6.1	-2.5	2.1	-0.7
Soleus weight	0.9	2.5	4.3	-1.7	2.1	-0.7
Tibialis anterior weight	2.7	9.2	13.9	-3.6	3.7	-0.9
Tibia length	0.2	0.6	1.4	0.4	0.5	-1.2
Number of licking bursts	0.2	0.2	0.6	0.7	-0.3	-0.2
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.7	0.8	-0.1
Times rat made contact with spout	0.1	0.1	0.2	-0.5	-0.3	-0.2
Mean time between licks in bursts	0.0	0.0	0.1	0.2	-0.0	0.3
Mean num. licks in bursts	0.3	0.4	0.9	-1.0	0.2	0.4
Std. dev. time between licks in bursts	0.6	0.8	1.4	-0.9	0.4	1.2
Water consumed over 24 hours	0.5	0.6	1.5	-0.4	0.5	-1.2
Indifference point 0 sec	2.6	4.2	8.3	-2.9	1.6	1.3
Indifference point AUC	1.6	1.9	2.4	0.9	-1.6	1.5
Indifference point function ln k	3.1	4.4	6.2	-1.1	2.4	-2.5
Indifference point function log k	3.1	4.4	6.2	-1.1	2.4	-2.5
Delay discounting total patch changes 0 sec	2.1	3.4	6.7	-2.6	1.6	1.0
Delay discounting total patch changes 12 sec	2.9	3.9	9.4	-1.4	-0.3	3.1
Delay discounting total patch changes 18 sec	2.1	2.7	6.5	-1.1	-0.7	2.6
Delay discounting total patch changes 24 sec	1.5	1.9	2.6	-1.6	0.9	1.6
Delay discounting total patch changes 6 sec	2.9	4.4	8.9	-2.0	0.4	3.0
Delay discounting time to switch 0 sec	0.7	1.0	1.6	0.7	-1.0	1.3
Delay discounting water rate 0 sec	1.7	2.6	4.8	-1.0	1.4	-2.2
Delay discounting water rate 12 sec	1.7	2.5	5.5	-0.6	1.3	-2.4
Delay discounting water rate 18 sec	2.7	3.6	4.0	-1.7	2.0	-2.0
Delay discounting water rate 24 sec	0.8	1.1	2.7	-1.6	0.7	-0.4
Delay discounting water rate 6 sec	2.5	3.7	5.1	-1.6	2.3	-1.8
Locomotor activity	0.6	0.9	2.7	-0.2	-0.1	-1.7
Locomotor testing distance	0.5	0.8	2.2	-0.3	0.2	-1.5
Locomotor testing rearing	0.2	0.4	1.0	-1.0	0.2	0.2
Light reinforcement 1	0.0	0.1	0.2	0.2	-0.2	-0.4
Light reinforcement 2	1.9	2.5	5.6	-0.0	1.3	-2.4
Reaction time number correct	3.4	4.9	6.8	-2.6	2.6	-1.1
Reaction time mean minus median	1.6	2.1	4.0	1.4	-2.0	0.6
Reaction time mean minus median AUC	2.7	3.5	5.6	1.7	-2.4	1.4
Reaction time num false alarms	0.5	0.6	1.3	0.6	-0.5	1.1
Reaction time num false alarms AUC	0.5	0.7	0.8	0.9	-0.8	0.9
Reaction time trials correct on left	3.4	4.9	6.8	-2.6	2.6	-1.1
Reaction time trials on left	3.3	4.7	6.7	-2.6	2.5	-1.0
Reaction time mean	1.1	1.5	2.3	1.1	-1.5	1.1
Reaction time mean AUC	1.1	1.4	2.2	1.1	-1.5	0.9
Median of all reaction times	0.6	0.8	0.9	0.8	-0.9	0.9
Reaction time omissions	2.6	3.6	8.4	0.5	-1.4	2.9
Reaction time false alarm rate	1.8	2.6	3.6	1.9	-1.7	1.1
Reaction time premature initiation rate	1.2	1.6	3.7	-0.1	1.0	-1.9
Reaction time premature initiations	2.6	3.7	4.8	-1.4	2.2	-2.1
Std. dev. reaction times	2.2	3.0	5.4	1.4	-2.3	1.4
Reaction time trials completed	3.3	4.7	6.7	-2.6	2.5	-1.0
Reaction time trials AUC	3.1	4.4	6.2	-2.5	2.5	-1.0
Social response proportion	0.1	0.1	0.4	-0.6	0.1	-0.0
Social responses	0.4	0.5	1.1	0.0	-0.5	1.0
Social time	1.2	1.5	3.7	-0.9	-0.3	1.9
Conditioned locomotion	0.1	0.1	0.3	-0.0	0.3	0.5
Cocaine response after cond. corrected	0.5	0.6	1.2	0.3	1.1	-0.6
Cocaine response after cond. not corrected	1.5	1.7	3.1	0.4	1.3	-1.8
Cocaine response before conditioning	1.0	1.2	3.6	0.1	0.1	-1.9
Saline control response	2.7	3.7	6.2	-1.3	2.5	-1.8
Condit. Reinf. active minus inactive responses	0.8	1.0	1.1	-1.0	0.9	-1.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.8	0.1	-0.4
Condit. Reinf. active responses	1.3	1.8	2.2	-1.1	1.5	-1.5
Condit. Reinf. inactive responses	0.6	0.8	1.7	-0.3	1.3	-0.7
Condit. Reinf. lever presses	1.1	1.5	3.3	-0.8	1.8	-0.7
Condit. Reinf. lever reinforcers received	1.5	2.1	2.7	-1.2	1.6	-1.4
Pavlov. Cond. lever latency	0.3	0.3	0.6	-0.6	0.1	0.8
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.3	0.1	0.6
Pavlov. Cond. change in total contacts	0.2	0.3	0.8	0.2	0.4	-0.9
Pavlov. Cond. index score	0.0	0.0	0.1	0.2	0.3	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	0.5	-0.4
Pavlov. Cond. lever contacts	0.0	0.1	0.1	0.3	0.3	-0.2
Pavlov. Cond. magazine entry number	0.7	0.9	1.2	1.1	-1.0	-0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	-0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.5	0.1	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	0.2	0.1	0.4
Conditioned reinforcement - actives	1.0	1.0	2.0	-0.4	0.9	-1.4
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.4	-0.3	0.6
Conditioned locomotion	0.8	1.0	1.5	-1.2	1.0	-0.7
Intermittent access intake day 1-15 change	0.8	0.8	1.1	0.6	-0.9	1.1
Intermittent access intake escalation	0.4	0.4	1.2	-0.2	-0.1	1.1
Intermittent access intake escalation 2	0.2	0.2	0.6	0.0	-0.1	0.8
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.7	0.5	0.2	-0.8
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.4	0.4	-0.5	0.7
Intermitt. access escalation Index	1.8	1.6	2.7	-1.5	1.6	-0.2
Intermittent access day 1 total infusions	0.2	0.2	0.4	-0.6	0.5	-0.2
Intermittent access day 15 total infusions	0.8	0.9	1.4	-1.2	0.8	0.9
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.6	-0.8	0.7	0.3
Intermittent access total infusions	1.1	1.2	1.8	-1.3	1.3	-0.1
Intermittent access day 1 locomotion	0.2	0.2	0.5	0.0	-0.1	-0.7
Intermittent access day 15 total locomotion	0.5	0.5	1.2	0.6	-1.1	0.2
Intermittent access total locomotion	0.2	0.2	0.4	0.2	-0.7	-0.3
Intermittent access standard deviation	0.1	0.2	0.3	-0.3	0.6	-0.2
Cocaine induced anxiety	3.9	4.5	9.3	-3.1	2.0	-0.1
Post-drug Anxiety	1.7	1.9	4.5	-2.1	0.9	0.4
Baseline Anxiety	1.5	1.6	2.3	1.5	-1.3	0.9
Lifetime Intake	2.0	2.3	3.6	-1.8	1.9	-0.2
Incentive Sensitization - Responses	0.5	0.5	1.0	-0.7	0.1	1.0
Incentive Sensitization - Breakpoint	0.3	0.3	0.8	-0.4	-0.1	0.9
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.4	-0.1	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.5	-0.2	-0.4
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.9	1.0	-0.3	-0.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.5	0.4	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.4	0.4	0.0
Progressive ratio test 2 inactive lever presses	0.4	0.4	1.2	-0.1	-0.0	1.1
Total sessions with >9 infusions	0.5	0.5	0.8	-0.9	0.8	0.3
Short access day 1 total inactive lever presses	0.3	0.3	0.4	-0.4	0.7	-0.6
Short access day 10 total inactive lever presses	0.5	0.6	1.1	1.0	-0.7	-0.3
Short access day 1 total infusions	2.6	2.7	4.2	-2.0	2.0	-0.1
Short access day 10 total infusions	1.0	1.1	1.5	-0.9	1.2	-1.0
Short access total infusions	1.9	2.1	3.3	-1.7	1.8	-0.2
Short access day 1 locomotion	0.1	0.1	0.1	0.3	-0.4	-0.2
Short access day 10 total locomotion	0.5	0.6	1.7	-0.2	-0.0	-1.3
Short access total locomotion	0.7	0.7	1.3	0.6	-0.7	-1.1
Compulsive drug intake	0.0	0.0	0.0	-0.0	0.1	-0.1
One hour access (0.3 mA shock)	0.4	0.5	1.0	-0.7	1.0	-0.3
One hour access (shock baseline)	0.8	0.9	1.6	-1.0	1.3	-0.5
Number of responses in last shaping day	1.2	1.3	3.6	0.3	0.4	-1.9
Context. condit. distance diff. score	1.0	1.2	1.9	-1.4	1.1	-0.7
Locomotion velocity, session 1	1.4	1.5	2.5	1.3	-1.6	-0.7
Locomotion distance, session 1	0.8	1.1	1.5	1.2	-0.9	-0.9
Locomotion velocity, session 2	1.7	2.0	3.1	1.8	-1.3	-1.1
Locomotion distance, session 2	0.8	1.1	2.4	1.6	-0.9	-0.0
Locomotion velocity, session 3	0.9	1.0	1.5	1.1	-1.2	0.5
Locomotion distance, session 3	1.3	1.4	2.4	1.1	-0.9	1.5
Stereotopy head waving bouts, day 3	0.6	0.8	1.7	-1.3	0.3	0.6
Stereotopy head waving duration, day 3	1.1	1.4	3.6	-1.9	0.6	0.4
Locomotion velocity, session 7	0.6	0.7	1.3	-0.5	0.6	-1.1
Locomotion distance, session 7	0.3	0.4	0.8	-0.7	0.9	-0.1
Stereotopy head waving bouts, day 7	1.6	1.9	2.8	0.2	-1.7	1.7
Stereotopy head waving duration, day 7	0.6	0.8	1.3	-0.2	-1.1	1.0
Locomotion velocity, session 8	0.1	0.1	0.2	-0.1	-0.4	-0.1
Locomotion distance, session 8	0.2	0.3	0.3	0.5	-0.5	-0.6
Degree of sensitization distance	2.7	2.7	4.0	-2.0	1.7	-1.1
Degree of sensitization stereotypy	1.8	2.0	3.2	0.7	-1.8	1.5
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	0.7	-0.8	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.0	-0.2	-0.4
Condit. Reinf. active responses	0.3	0.4	0.6	0.7	-0.7	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	-0.2	0.6
Incentive salience index mean	0.7	0.8	1.4	0.9	-0.5	-1.2
Condit. Reinf. lever presses	0.8	1.1	3.1	0.4	0.3	-1.8
Time in familiar zone, hab. session 1	0.8	0.8	1.3	-0.4	1.2	-0.9
Time in novel zone, hab. session 1	0.6	0.6	1.0	-0.2	-0.9	1.0
Total zone transitions, hab. session 1	2.0	2.8	5.0	1.7	-2.2	-0.5
Total locomotion distance, hab. session 1	0.4	0.6	1.3	0.8	-1.1	-0.1
Locomotion velocity, hab. session 1	0.4	0.6	0.9	0.8	-1.0	-0.3
Time in familiar zone, hab. session 2	0.8	0.9	2.4	-0.1	-0.5	1.5
Time in novel zone, hab. session 2	0.6	0.6	1.2	-0.3	0.7	-1.1
Total zone transitions, hab. session 2	1.7	2.2	3.8	1.5	-0.7	-1.9
Total locomotion distance, hab. session 2	1.2	1.6	3.8	0.9	0.6	-1.9
Locomotion velocity, hab. session 2	1.5	2.0	4.4	1.1	0.6	-2.1
Novel to familiar place preference ratio	1.5	1.6	2.2	-1.3	1.5	-0.9
Novelty place preference	1.1	1.1	1.4	-1.1	1.2	-0.8
Time in novel zone, NPP test	1.0	1.1	1.5	-1.2	1.1	-0.8
Total zone transitions, NPP test	0.9	1.3	2.6	1.6	-1.1	-0.5
Total locomotion distance, NPP test	0.2	0.3	0.8	0.9	0.1	-0.1
Locomotion velocity, NPP test	0.4	0.5	1.5	1.2	-0.2	0.4
Pavlov. Cond. lever latency	1.2	1.5	2.9	-1.2	0.3	1.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.0	0.1	-0.4
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	0.2	0.6	-0.9
Pavlov. Cond. index score	0.4	0.5	1.3	0.5	0.1	-1.1
Pavlov. Cond. latency score	0.4	0.5	1.2	0.5	0.1	-1.1
Pavlov. Cond. lever contacts	1.1	1.3	3.1	0.8	0.0	-1.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	-0.1	0.7	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.0	0.4	0.2	-1.4
Pavlov. Cond. response bias	0.7	0.9	2.1	0.8	-0.1	-1.4
Bone: apparent density	2.2	3.7	9.2	0.5	1.3	-3.0
Bone surface	3.9	6.8	14.9	-0.1	2.3	-3.9
Bone volume	3.2	5.5	12.4	-0.1	2.0	-3.5
Bone: connectivity density	3.4	5.4	13.5	1.1	1.2	-3.7
Bone: cortical apparent density	1.4	1.8	3.4	1.1	-1.8	0.8
Bone: cortical area	2.0	3.0	3.9	-1.3	1.8	-2.0
Bone: cortical porosity	0.3	0.3	0.6	-0.3	0.5	-0.7
Bone: cortical porosity	0.3	0.3	0.4	-0.7	0.6	-0.4
Bone: cortical thickness	0.5	0.8	1.9	-0.5	0.5	-1.4
Bone: cortical thickness	0.3	0.4	0.7	0.5	-0.8	-0.3
Bone: cortical tissue density	1.7	2.2	4.0	1.2	-2.0	1.0
Bone: elastic displacement	4.9	5.6	8.5	2.9	-2.9	0.2
Bone: elastic work	1.7	2.2	3.6	1.7	-1.9	-0.4
Bone: endosteal estimation	0.4	0.9	2.0	-0.9	1.4	-0.2
Bone: endosteal perimeter	1.4	2.9	4.1	-0.8	2.0	-2.0
Bone: final force	1.2	1.9	2.4	-1.2	1.4	-1.6
Bone: final moment	0.6	1.0	1.4	-0.9	0.9	-1.2
Bone: marrow area	0.5	1.0	2.1	-0.9	1.4	-0.3
Bone: maximum diameter	0.9	1.7	2.9	-1.4	1.7	-0.5
Bone: maximum force	0.8	1.4	2.2	-0.7	1.2	-1.5
Bone: maximum moment	0.3	0.6	1.1	-0.4	0.7	-1.0
Bone: minimum diameter	2.7	5.1	7.0	-1.7	2.6	-2.3
Bone: periosteal estimation	1.5	3.0	4.8	-1.5	2.2	-1.4
Bone: periosteal perimeter	3.7	6.1	9.2	-1.3	2.7	-3.0
Bone: post-yield work	1.0	1.3	2.1	-1.3	1.5	0.6
Bone: stiffness	1.4	2.3	2.5	-1.3	1.6	-1.6
Bone: tissue strength	0.8	0.8	2.2	0.2	-0.4	1.5
Bone: trabecular number	3.1	4.9	9.5	0.1	2.3	-3.1
Bone: trabecular spacing	2.3	2.9	6.3	0.2	-1.6	2.5
Bone: trabecular thickness	2.9	3.6	7.5	1.7	-0.7	-2.7
Bone: trabecular tissue density	0.9	1.3	3.1	-0.6	-0.7	1.8
Breakpoint value in progressive ratio session	1.0	1.1	2.2	-1.0	0.0	1.5
Distance traveled before self-admin	0.6	0.7	1.2	-1.1	0.9	-0.3
Distance traveled after self-admin	0.1	0.1	0.4	0.1	-0.0	-0.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.6	0.4	-0.4
Delta time in open arm before/after self-admin	1.7	1.7	2.0	1.4	-1.3	1.1
Diff in mean of infusions in LGA sessions	2.6	3.0	4.7	-2.2	2.0	-0.4
Extinction: sum of active levers before priming	0.3	0.3	0.7	-0.5	0.1	0.9
Active lever presses in extinction session 6	1.1	1.0	1.9	0.3	-1.0	1.4
Delta distance traveled before/after self-admin	0.9	0.9	1.4	1.2	-1.0	-0.6
Delta ambulatory time before/after self-admin	0.6	0.7	1.1	1.1	-0.9	-0.3
Time in closed arm before self-admin	0.8	0.9	2.6	-0.3	0.1	1.6
Time in closed arm after self-admin	0.3	0.4	1.0	-0.2	0.2	1.0
Time in open arm before self-admin	2.0	2.2	3.4	-1.2	1.8	-1.3
Time in open arm after self-admin	0.0	0.0	0.1	0.3	0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.1	-0.5	0.8	-1.0
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.7	0.7	-0.1
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.0	0.8	-1.0	1.0
Time to tail flick, test, before self-admin	0.4	0.4	0.6	0.2	-0.7	0.8
Time to tail flick, test, after self-admin	0.9	0.9	1.8	1.4	-1.0	0.1
Delta time to tail flick, vehicle, before/after SA	2.4	2.3	4.0	2.0	-1.7	0.3
Delta time to tail flick, test, before/after SA	0.3	0.2	0.6	0.3	0.2	-0.8
Ambulatory time before self-admin	0.7	0.7	1.3	-1.1	0.8	-0.5
Ambulatory time after self-admin	0.3	0.3	0.9	0.2	0.0	-0.9
Total heroin consumption	0.7	0.8	1.9	-0.1	-0.6	1.4
Area under the delay curve	0.0	0.0	0.0	0.0	0.1	0.0
Delay disc. indifference point, 0s delay	0.6	0.7	0.9	-0.8	0.9	-0.8
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.1	0.2	0.3
Delay disc. indifference point, 2s delay	0.9	1.0	1.8	1.1	-0.2	-1.3
Delay disc. indifference point, 24s delay	2.1	2.1	3.7	-1.9	1.1	1.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.2	-0.7	0.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	-0.1	0.2
Delay discount exponential model param	0.0	0.0	0.0	-0.0	0.0	-0.2
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.1	0.1	0.0
Fecal boli incidents, locomotor time 1	0.3	0.3	0.7	-0.5	0.9	-0.2
Change in fecal boli incidents, locomotor task	1.0	0.9	1.4	-1.2	0.2	1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.1	-0.5	0.3
Bouts of movement, locomotor time 1	1.6	1.7	3.2	0.3	-1.4	1.8
Total resting periods, locomotor time 1	1.5	1.6	3.4	-0.0	-1.2	1.8
Rest time, locomotor task time 1	0.9	1.0	2.4	-0.3	-0.7	1.5
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.1	0.4	-0.4
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.3	0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	0.3	0.1	-0.7
Bouts of movement, locomotor time 2	0.3	0.3	0.6	-0.2	-0.8	0.5
Total resting periods, locomotor time 2	0.5	0.5	0.9	-0.3	-0.8	0.9
Rest time, locomotor task time 2	2.8	3.2	7.8	-1.3	-0.5	2.8
Distance moved, locomotor task time 2	0.6	0.7	1.9	0.0	0.4	-1.4
Vertical activity count, locomotor time 2	0.3	0.3	0.5	0.7	0.2	-0.7
Weight adjusted by age	0.4	0.5	0.7	0.8	-0.2	-0.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.6	0.8	0.4	-0.7
Locomotion in novel chamber	1.1	1.3	3.4	-0.2	0.7	-1.8
Locomotion in novel chamber post-restriction	2.0	2.3	4.2	-2.0	1.5	-0.8
Progressive ratio	0.7	0.8	1.3	1.1	-0.9	-0.6
Food seeking constrained by brief footshock	0.4	0.5	0.8	0.9	-0.7	0.4
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	-0.0	0.1	0.4
Run reversals in cocaine runway, females	0.4	0.4	0.7	-0.4	0.4	-0.9
Run reversals in cocaine runway, males	1.8	1.7	2.9	0.8	-1.2	1.7
Latency to leave start box in cocaine runway	0.8	0.9	1.5	1.0	-0.1	-1.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.0	0.3	-0.3
Latency to leave start box in cocaine runway, M	3.0	2.8	5.8	1.6	-0.2	-2.4
Cd content in liver	0.2	0.3	0.4	0.6	-0.6	0.3
Co content in liver	0.2	0.2	0.2	0.4	-0.4	0.4
Cu content in liver	0.1	0.1	0.2	-0.2	0.4	0.0
Fe content in liver	0.4	0.5	1.2	1.1	-0.4	0.2
K content in liver	1.5	1.5	2.2	1.4	-1.5	0.6
Mg content in liver	0.1	0.1	0.1	-0.2	0.1	0.3
Mn content in liver	0.9	1.1	1.7	-0.6	1.3	-1.1
Na content in liver	0.1	0.1	0.1	-0.4	0.3	-0.2
Rb content in liver	1.4	1.7	4.9	-0.1	-0.4	2.2
Se content in liver	0.1	0.2	0.3	0.3	0.6	-0.3
Sr content in liver	0.8	0.7	1.4	0.6	-0.6	-1.2
Zn content in liver	0.2	0.2	0.5	-0.7	0.4	0.2