Hub : Genes

Nckap5l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000056678 0.03 0.03 2.3e-03 0.01 0.01 0 0.01 1.2e-02 1.6e-02 8.2e-02 2.5e-02
2 Brain gene expression ENSRNOG00000056678 0.04 0.03 2.5e-04 0.01 0.04 0.03 0.03 2.0e-02 2.4e-04 2.1e-03 1.4e-03
3 PL gene expression ENSRNOG00000056678 0.03 0.03 2.0e-03 0.02 0.03 0.01 0.02 1.3e-02 2.5e-03 4.8e-02 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail4.514.715.4-3.63.93.9
BMI without tail0.00.00.10.30.10.1
Body weight6.025.325.7-4.95.15.1
Epididymis fat weight0.10.30.4-0.60.50.5
Glucose0.00.00.0-0.1-0.2-0.2
Heart weight0.10.10.1-0.30.30.3
Left kidney weight0.51.41.6-1.01.31.3
Right kidney weight2.47.07.2-2.62.72.7
Tail length0.10.30.40.6-0.5-0.5
Length with tail1.97.17.2-2.72.72.7
Length without tail7.516.316.9-4.14.04.0
Liver weight, left1.93.13.2-1.81.81.8
Liver weight, right1.62.62.7-1.61.61.6
Parametrial fat weight2.24.44.92.2-2.0-2.0
Retroperitoneal fat weight0.72.42.81.2-1.7-1.7
Intraocular pressure7.610.811.23.3-3.3-3.3
Extensor digitorum longus weight4.216.818.0-3.84.24.2
Soleus weight0.82.42.6-1.41.61.6
Tibialis anterior weight1.24.05.0-1.52.22.2
Tibia length6.518.318.4-4.34.34.3
Number of licking bursts0.91.01.20.9-1.1-1.1
Food consumed during 24 hour testing period1.72.12.1-1.41.51.5
Times rat made contact with spout0.10.10.10.4-0.3-0.3
Mean time between licks in bursts0.00.00.00.1-0.1-0.1
Mean num. licks in bursts0.20.20.3-0.30.50.5
Std. dev. time between licks in bursts1.51.81.81.3-1.4-1.3
Water consumed over 24 hours0.00.00.0-0.1-0.0-0.0
Indifference point 0 sec3.65.86.62.1-2.6-2.6
Indifference point AUC0.30.40.40.7-0.6-0.6
Indifference point function ln k4.76.77.0-2.52.62.6
Indifference point function log k4.76.77.0-2.52.62.6
Delay discounting total patch changes 0 sec3.45.56.22.0-2.5-2.5
Delay discounting total patch changes 12 sec3.64.85.41.9-2.3-2.3
Delay discounting total patch changes 18 sec5.77.58.12.5-2.8-2.8
Delay discounting total patch changes 24 sec3.13.94.51.7-2.1-2.1
Delay discounting total patch changes 6 sec4.06.27.12.1-2.7-2.7
Delay discounting time to switch 0 sec2.64.04.22.1-2.0-2.0
Delay discounting water rate 0 sec3.04.85.0-2.12.22.2
Delay discounting water rate 12 sec3.75.55.6-2.32.42.4
Delay discounting water rate 18 sec0.30.40.4-0.60.70.6
Delay discounting water rate 24 sec3.95.46.0-2.12.42.4
Delay discounting water rate 6 sec4.46.47.0-2.32.62.6
Locomotor activity1.52.32.41.5-1.5-1.5
Locomotor testing distance3.66.06.32.3-2.5-2.5
Locomotor testing rearing2.74.24.32.0-2.1-2.1
Light reinforcement 12.54.55.12.3-2.1-2.1
Light reinforcement 20.50.71.01.0-0.7-0.7
Reaction time number correct2.02.83.4-1.81.61.6
Reaction time mean minus median8.711.311.73.4-3.3-3.3
Reaction time mean minus median AUC6.17.88.22.9-2.8-2.8
Reaction time num false alarms1.72.42.51.5-1.6-1.6
Reaction time num false alarms AUC2.33.23.21.8-1.8-1.8
Reaction time trials correct on left2.02.83.4-1.81.61.6
Reaction time trials on left1.62.32.8-1.71.41.4
Reaction time mean0.81.11.21.1-1.1-1.1
Reaction time mean AUC0.50.70.70.8-0.8-0.8
Median of all reaction times0.00.00.00.0-0.0-0.0
Reaction time omissions10.213.714.03.6-3.7-3.7
Reaction time false alarm rate2.94.14.52.1-2.0-2.0
Reaction time premature initiation rate6.99.29.43.1-3.0-3.0
Reaction time premature initiations2.84.04.12.0-2.0-2.0
Std. dev. reaction times6.69.19.13.0-3.0-3.0
Reaction time trials completed1.62.32.8-1.71.41.4
Reaction time trials AUC2.53.54.2-2.01.81.8
Social response proportion0.20.20.40.6-0.4-0.4
Social responses8.410.911.43.4-3.3-3.3
Social time0.00.00.1-0.00.30.3
Conditioned locomotion0.00.00.0-0.20.10.1
Cocaine response after cond. corrected0.00.00.00.0-0.0-0.0
Cocaine response after cond. not corrected0.40.50.50.7-0.7-0.7
Cocaine response before conditioning3.34.04.12.0-2.0-2.0
Saline control response0.10.10.2-0.40.30.3
Condit. Reinf. active minus inactive responses0.10.10.10.10.30.3
Condit. Reinf. active-inactive response ratio0.10.10.30.5-0.0-0.0
Condit. Reinf. active responses0.10.10.20.5-0.2-0.2
Condit. Reinf. inactive responses0.70.90.90.9-1.0-1.0
Condit. Reinf. lever presses0.00.00.0-0.00.00.0
Condit. Reinf. lever reinforcers received0.30.50.60.8-0.6-0.6
Pavlov. Cond. lever latency0.10.20.3-0.20.50.5
Pavlov. Cond. magazine entry latency0.70.81.4-1.20.70.7
Pavlov. Cond. change in total contacts1.01.41.6-1.31.11.1
Pavlov. Cond. index score0.20.20.6-0.80.20.3
Pavlov. Cond. latency score0.20.30.6-0.80.30.3
Pavlov. Cond. lever contacts0.30.40.50.5-0.7-0.7
Pavlov. Cond. magazine entry number1.41.72.81.7-1.1-1.1
Pavlov. Cond. intertrial magazine entries5.06.57.42.7-2.5-2.5
Pavlov. Cond. lever-magazine prob. diff.0.50.61.1-1.10.60.6
Pavlov. Cond. response bias0.10.10.10.1-0.3-0.3
Conditioned reinforcement - actives1.81.81.81.4-1.3-1.3
Conditioned reinforcement - inactives2.52.82.91.6-1.7-1.7
Conditioned locomotion0.40.40.50.7-0.6-0.6
Intermittent access intake day 1-15 change1.41.41.91.4-1.1-1.0
Intermittent access intake escalation0.90.91.41.2-0.8-0.8
Intermittent access intake escalation 21.51.52.21.5-1.1-1.1
Intermitt. access day 1 inactive lever presses1.41.61.81.3-1.2-1.2
Intermitt. access day 15 inactive lever presses0.80.91.31.1-0.9-0.9
Intermitt. access escalation Index0.30.30.40.4-0.6-0.6
Intermittent access day 1 total infusions1.41.61.71.2-1.3-1.3
Intermittent access day 15 total infusions3.23.54.02.0-1.8-1.8
Intermittent access terminal intake (last 3 days)3.43.74.32.1-1.9-1.9
Intermittent access total infusions3.23.54.02.0-1.8-1.8
Intermittent access day 1 locomotion1.01.11.20.9-1.1-1.1
Intermittent access day 15 total locomotion1.92.02.01.4-1.4-1.4
Intermittent access total locomotion4.04.54.81.9-2.2-2.2
Intermittent access standard deviation0.40.40.60.8-0.5-0.5
Cocaine induced anxiety1.01.21.2-1.01.11.1
Post-drug Anxiety5.35.96.3-2.32.52.5
Baseline Anxiety0.91.01.0-0.91.01.0
Lifetime Intake3.53.94.12.0-1.9-1.9
Incentive Sensitization - Responses0.00.00.00.10.10.1
Incentive Sensitization - Breakpoint0.00.00.00.20.00.0
Progressive ratio test 1 active lever presses6.87.07.62.4-2.8-2.8
Progressive ratio test 1 breakpoint6.16.36.82.3-2.6-2.6
Progressive ratio test 1 inactive lever presses3.53.73.81.9-1.9-1.9
Progressive ratio test 2 active lever presses3.03.23.31.8-1.8-1.8
Progressive ratio test 2 breakpoint3.64.04.22.1-2.0-2.0
Progressive ratio test 2 inactive lever presses2.52.93.21.8-1.7-1.7
Total sessions with >9 infusions1.82.02.01.4-1.4-1.4
Short access day 1 total inactive lever presses1.82.02.01.4-1.4-1.4
Short access day 10 total inactive lever presses0.00.00.00.2-0.1-0.1
Short access day 1 total infusions0.30.30.40.4-0.6-0.6
Short access day 10 total infusions1.92.12.31.3-1.5-1.5
Short access total infusions1.41.51.61.1-1.3-1.3
Short access day 1 locomotion0.20.20.30.4-0.5-0.5
Short access day 10 total locomotion0.10.10.10.3-0.4-0.4
Short access total locomotion0.50.60.60.7-0.8-0.8
Compulsive drug intake1.51.51.6-1.11.31.3
One hour access (0.3 mA shock)0.40.40.90.9-0.5-0.5
One hour access (shock baseline)0.30.30.50.7-0.5-0.5
Number of responses in last shaping day0.00.00.10.00.30.3
Context. condit. distance diff. score0.20.30.3-0.50.50.5
Locomotion velocity, session 11.61.72.20.9-1.5-1.5
Locomotion distance, session 12.63.43.71.7-1.9-1.9
Locomotion velocity, session 20.20.30.30.5-0.5-0.5
Locomotion distance, session 22.43.53.81.7-2.0-2.0
Locomotion velocity, session 34.55.35.72.1-2.4-2.4
Locomotion distance, session 35.15.65.92.4-2.3-2.3
Stereotopy head waving bouts, day 30.60.71.0-1.00.80.8
Stereotopy head waving duration, day 30.30.30.5-0.70.50.5
Locomotion velocity, session 70.80.91.20.7-1.1-1.1
Locomotion distance, session 72.63.43.91.6-2.0-2.0
Stereotopy head waving bouts, day 70.70.80.8-0.90.90.9
Stereotopy head waving duration, day 71.21.51.5-1.21.21.2
Locomotion velocity, session 80.00.00.0-0.2-0.2-0.2
Locomotion distance, session 81.11.71.81.2-1.3-1.3
Degree of sensitization distance0.30.30.5-0.70.50.5
Degree of sensitization stereotypy0.20.20.3-0.40.50.5
Condit. Reinf. active minus inactive responses0.10.10.10.4-0.3-0.3
Condit. Reinf. active-inactive response ratio0.20.20.2-0.40.50.5
Condit. Reinf. active responses0.80.91.01.0-1.0-1.0
Condit. Reinf. inactive responses3.03.53.71.8-1.9-1.9
Incentive salience index mean0.00.00.00.00.10.1
Condit. Reinf. lever presses0.10.20.2-0.30.50.5
Time in familiar zone, hab. session 10.10.10.20.5-0.3-0.3
Time in novel zone, hab. session 10.20.20.3-0.50.40.4
Total zone transitions, hab. session 10.20.30.30.5-0.5-0.5
Total locomotion distance, hab. session 10.00.00.0-0.1-0.2-0.2
Locomotion velocity, hab. session 10.00.00.0-0.2-0.0-0.0
Time in familiar zone, hab. session 20.70.80.9-0.71.00.9
Time in novel zone, hab. session 20.60.60.80.5-0.9-0.9
Total zone transitions, hab. session 20.30.30.40.5-0.6-0.6
Total locomotion distance, hab. session 20.20.20.20.4-0.5-0.5
Locomotion velocity, hab. session 20.10.10.10.3-0.3-0.3
Novel to familiar place preference ratio1.92.02.2-1.51.41.4
Novelty place preference1.41.41.7-1.31.11.1
Time in novel zone, NPP test1.11.21.5-1.21.01.0
Total zone transitions, NPP test1.72.42.81.3-1.7-1.7
Total locomotion distance, NPP test2.23.13.41.5-1.8-1.8
Locomotion velocity, NPP test1.31.82.11.2-1.4-1.4
Pavlov. Cond. lever latency0.20.20.6-0.80.30.3
Pavlov. Cond. magazine entry latency0.10.10.20.00.40.4
Pavlov. Cond. change in total contacts0.10.10.20.20.40.4
Pavlov. Cond. index score0.10.10.10.30.20.3
Pavlov. Cond. latency score0.00.10.20.40.10.1
Pavlov. Cond. lever contacts0.50.61.21.1-0.6-0.6
Pavlov. Cond. magazine entry number0.00.00.1-0.3-0.1-0.1
Pavlov. Cond. intertrial magazine entries1.01.21.60.6-1.3-1.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.10.50.6
Pavlov. Cond. response bias0.10.10.20.5-0.1-0.1
Bone: apparent density10.517.417.5-4.24.24.2
Bone surface12.521.922.4-4.64.74.7
Bone volume9.816.517.4-3.94.14.2
Bone: connectivity density7.111.211.9-3.43.33.3
Bone: cortical apparent density0.30.40.40.6-0.6-0.6
Bone: cortical area8.713.113.2-3.63.63.6
Bone: cortical porosity0.30.30.50.7-0.5-0.5
Bone: cortical porosity0.60.71.01.0-0.7-0.7
Bone: cortical thickness2.74.44.7-2.22.12.1
Bone: cortical thickness0.00.00.0-0.1-0.1-0.1
Bone: cortical tissue density0.40.50.50.7-0.7-0.7
Bone: elastic displacement4.65.35.82.0-2.4-2.4
Bone: elastic work0.00.10.1-0.30.20.2
Bone: endosteal estimation8.518.319.0-4.14.34.4
Bone: endosteal perimeter7.114.615.4-3.63.93.9
Bone: final force11.318.519.2-4.14.44.4
Bone: final moment12.420.421.3-4.34.64.6
Bone: marrow area8.217.718.3-4.14.34.3
Bone: maximum diameter2.85.25.5-2.42.22.3
Bone: maximum force16.328.429.1-5.25.45.4
Bone: maximum moment17.530.531.5-5.45.65.6
Bone: minimum diameter9.617.718.4-4.04.34.3
Bone: periosteal estimation11.824.224.8-4.85.05.0
Bone: periosteal perimeter10.417.218.0-4.04.24.2
Bone: post-yield work10.013.613.8-3.63.73.7
Bone: stiffness19.130.231.5-5.35.65.6
Bone: tissue strength2.01.91.9-1.41.41.4
Bone: trabecular number6.510.210.2-3.23.23.2
Bone: trabecular spacing2.53.23.41.8-1.8-1.8
Bone: trabecular thickness0.10.10.20.40.10.1
Bone: trabecular tissue density0.00.10.10.30.20.2
Breakpoint value in progressive ratio session0.20.20.3-0.50.50.5
Distance traveled before self-admin1.51.61.91.0-1.4-1.4
Distance traveled after self-admin0.30.30.40.4-0.6-0.6
Delta time in closed arm before/after self-admin0.20.20.2-0.40.50.5
Delta time in open arm before/after self-admin4.44.24.32.0-2.1-2.1
Diff in mean of infusions in LGA sessions1.71.91.9-1.41.41.4
Extinction: sum of active levers before priming0.70.70.7-0.80.80.8
Active lever presses in extinction session 60.30.30.3-0.60.60.6
Delta distance traveled before/after self-admin0.10.10.1-0.20.30.3
Delta ambulatory time before/after self-admin0.00.00.00.10.10.1
Time in closed arm before self-admin1.51.71.8-1.31.31.3
Time in closed arm after self-admin0.70.70.7-0.80.90.9
Time in open arm before self-admin0.50.50.6-0.80.70.7
Time in open arm after self-admin0.20.20.30.4-0.5-0.5
Sum of active levers in priming session hrs 5-60.10.10.1-0.1-0.3-0.3
Time to tail flick, vehicle, before self-admin0.90.91.01.0-0.9-0.9
Time to tail flick, vehicle, after self-admin0.40.40.5-0.60.70.7
Time to tail flick, test, before self-admin0.10.10.10.3-0.4-0.4
Time to tail flick, test, after self-admin0.40.40.5-0.60.70.7
Delta time to tail flick, vehicle, before/after SA0.60.60.6-0.80.80.8
Delta time to tail flick, test, before/after SA0.30.20.3-0.30.60.6
Ambulatory time before self-admin4.04.24.61.9-2.1-2.2
Ambulatory time after self-admin2.12.32.41.5-1.6-1.5
Total heroin consumption1.92.32.4-1.61.51.5
Area under the delay curve1.01.01.1-0.91.11.1
Delay disc. indifference point, 0s delay1.51.61.8-1.11.41.4
Delay disc. indifference point, 16s delay0.90.91.0-0.91.01.0
Delay disc. indifference point, 2s delay1.82.02.1-1.31.41.5
Delay disc. indifference point, 24s delay1.21.11.2-1.11.01.0
Delay disc. indifference point, 4s delay0.50.50.6-0.50.80.8
Delay disc. indifference point, 8s delay2.22.32.4-1.51.51.5
Delay discount exponential model param0.91.01.10.9-1.0-1.0
Delay discount hyperbolic model param1.01.01.10.9-1.1-1.1
Fecal boli incidents, locomotor time 12.22.42.41.6-1.5-1.5
Change in fecal boli incidents, locomotor task1.41.31.5-1.21.11.1
Time >=10cm from walls, locomotor time 10.00.10.1-0.40.00.0
Bouts of movement, locomotor time 10.00.00.0-0.10.10.1
Total resting periods, locomotor time 10.20.20.20.4-0.5-0.5
Rest time, locomotor task time 10.50.50.60.7-0.8-0.8
Distance moved, locomotor task time 10.00.00.1-0.30.10.1
Vertical activity count, locomotor time 11.31.31.3-1.21.11.1
Time >=10cm from walls, locomotor time 20.70.70.70.9-0.8-0.8
Bouts of movement, locomotor time 23.03.23.4-1.71.81.8
Total resting periods, locomotor time 23.43.63.9-1.82.02.0
Rest time, locomotor task time 20.00.00.0-0.0-0.1-0.1
Distance moved, locomotor task time 20.00.00.00.1-0.2-0.2
Vertical activity count, locomotor time 20.00.00.0-0.00.10.1
Weight adjusted by age1.51.72.2-1.51.21.2
Seeking ratio, delayed vs. immediate footshock0.40.40.5-0.60.70.7
Locomotion in novel chamber1.01.21.5-0.71.21.2
Locomotion in novel chamber post-restriction0.10.10.2-0.00.40.4
Progressive ratio0.20.30.40.2-0.6-0.6
Food seeking constrained by brief footshock0.70.81.00.7-1.0-1.0
Seeking ratio, punishment vs. effort0.00.00.00.20.10.1
Run reversals in cocaine runway, females0.10.10.10.00.30.3
Run reversals in cocaine runway, males1.51.41.51.2-1.2-1.2
Latency to leave start box in cocaine runway0.00.00.00.0-0.1-0.1
Latency to leave start box in cocaine runway, F1.92.02.21.3-1.5-1.5
Latency to leave start box in cocaine runway, M2.22.12.2-1.41.51.5
Cd content in liver0.80.90.91.0-0.9-0.9
Co content in liver0.91.11.11.1-1.0-1.0
Cu content in liver0.60.70.9-0.90.80.8
Fe content in liver0.60.70.80.7-0.9-0.9
K content in liver0.10.10.2-0.40.20.2
Mg content in liver0.10.10.10.2-0.4-0.3
Mn content in liver0.10.10.1-0.40.40.4
Na content in liver0.10.10.10.2-0.4-0.4
Rb content in liver0.91.11.40.8-1.2-1.2
Se content in liver1.21.41.71.0-1.3-1.3
Sr content in liver0.10.10.1-0.30.20.2
Zn content in liver2.73.03.21.6-1.8-1.8