Hub : Genes

Snord104

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000056422 0.28 0.1 0.0e+00 0.3 0.32 0.32 0.33 2.9e-16 8.4e-18 1.9e-17 4.2e-18
2 Brain gene expression ENSRNOG00000056422 0.25 0.07 0.0e+00 0.31 0.31 0.32 0.32 4.5e-29 4.3e-29 6.4e-30 6.1e-30
3 Liver gene expression ENSRNOG00000056422 0.08 0.03 9.4e-12 0.1 0.11 0.09 0.1 3.3e-11 6.6e-12 1.4e-10 4.5e-11
4 PL gene expression ENSRNOG00000056422 0.13 0.05 1.6e-14 0.21 0.18 0.21 0.21 4.8e-16 1.7e-13 5.1e-16 4.9e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.10.20.30.2-0.6-0.3-0.5
BMI without tail1.53.24.6-1.2-2.1-1.6-2.1
Body weight1.87.68.7-2.9-2.7-2.5-2.8
Epididymis fat weight1.02.32.9-1.0-1.7-1.7-1.6
Glucose0.91.41.71.31.11.11.3
Heart weight0.00.00.10.3-0.10.10.0
Left kidney weight0.82.43.91.01.52.01.6
Right kidney weight0.51.42.70.21.31.61.1
Tail length2.36.97.8-2.8-2.5-2.4-2.7
Length with tail1.76.310.4-3.2-2.1-2.2-2.5
Length without tail0.20.51.6-1.3-0.1-0.4-0.3
Liver weight, left0.71.22.0-1.4-0.9-0.9-1.1
Liver weight, right0.81.32.00.61.41.31.1
Parametrial fat weight0.71.42.4-1.5-0.9-0.9-1.3
Retroperitoneal fat weight1.55.07.1-2.7-2.0-2.1-2.1
Intraocular pressure0.81.11.9-0.3-1.4-1.1-1.1
Extensor digitorum longus weight0.62.38.22.90.5-0.20.8
Soleus weight0.10.20.3-0.5-0.3-0.0-0.5
Tibialis anterior weight0.51.62.5-0.2-1.4-1.6-1.4
Tibia length0.30.81.4-0.51.01.20.7
Number of licking bursts0.00.00.0-0.00.10.20.1
Food consumed during 24 hour testing period3.94.75.2-2.0-2.3-2.2-2.2
Times rat made contact with spout0.70.81.6-1.3-0.8-0.7-0.7
Mean time between licks in bursts0.10.10.20.0-0.3-0.5-0.3
Mean num. licks in bursts0.40.40.5-0.5-0.7-0.7-0.6
Std. dev. time between licks in bursts0.10.10.10.4-0.3-0.3-0.3
Water consumed over 24 hours0.10.10.2-0.5-0.00.1-0.0
Indifference point 0 sec4.67.48.3-2.6-2.8-2.6-2.9
Indifference point AUC1.41.62.0-1.2-1.1-1.4-1.3
Indifference point function ln k0.40.51.20.70.41.10.5
Indifference point function log k0.40.51.20.70.41.10.5
Delay discounting total patch changes 0 sec4.77.78.3-2.8-2.8-2.7-2.9
Delay discounting total patch changes 12 sec6.78.910.5-2.8-2.9-3.2-3.0
Delay discounting total patch changes 18 sec3.04.04.2-2.0-2.0-2.0-1.9
Delay discounting total patch changes 24 sec3.64.55.1-2.3-2.0-1.9-2.3
Delay discounting total patch changes 6 sec2.43.74.3-2.0-1.8-1.8-2.1
Delay discounting time to switch 0 sec0.20.30.30.40.50.50.6
Delay discounting water rate 0 sec1.42.22.6-1.6-1.4-1.3-1.5
Delay discounting water rate 12 sec1.72.64.01.11.72.01.5
Delay discounting water rate 18 sec0.30.41.1-0.10.71.10.5
Delay discounting water rate 24 sec0.10.10.3-0.10.30.50.4
Delay discounting water rate 6 sec0.20.30.90.20.51.00.4
Locomotor activity0.60.91.8-1.3-1.0-0.3-0.8
Locomotor testing distance1.72.94.0-1.9-2.0-1.1-1.6
Locomotor testing rearing1.62.53.5-1.8-1.9-1.2-1.3
Light reinforcement 10.50.91.9-0.0-1.1-0.8-1.4
Light reinforcement 20.70.91.8-0.3-1.1-0.8-1.3
Reaction time number correct0.81.21.41.01.01.21.1
Reaction time mean minus median0.30.40.50.70.60.30.7
Reaction time mean minus median AUC1.41.72.11.41.31.11.4
Reaction time num false alarms2.83.84.9-2.2-2.0-1.5-2.0
Reaction time num false alarms AUC3.14.45.6-2.4-2.0-1.7-2.2
Reaction time trials correct on left0.81.21.41.01.01.21.1
Reaction time trials on left0.81.21.31.01.01.21.1
Reaction time mean1.01.41.91.11.31.01.4
Reaction time mean AUC1.31.72.21.31.31.11.5
Median of all reaction times1.01.41.81.11.31.01.3
Reaction time omissions0.10.10.20.40.30.10.3
Reaction time false alarm rate3.54.96.3-2.5-2.1-1.9-2.3
Reaction time premature initiation rate0.91.21.8-0.8-1.3-0.9-1.3
Reaction time premature initiations0.20.30.7-0.3-0.8-0.4-0.7
Std. dev. reaction times0.50.60.90.80.90.51.0
Reaction time trials completed0.81.21.31.01.01.21.1
Reaction time trials AUC0.81.21.41.01.01.11.2
Social response proportion0.20.20.40.60.30.40.6
Social responses0.00.00.1-0.2-0.3-0.0-0.2
Social time0.00.00.1-0.1-0.4-0.1-0.1
Conditioned locomotion0.91.11.6-0.5-1.2-1.3-1.0
Cocaine response after cond. corrected0.50.60.80.60.80.80.9
Cocaine response after cond. not corrected1.31.42.00.41.31.41.3
Cocaine response before conditioning0.40.41.0-0.20.71.00.5
Saline control response2.02.73.8-1.1-1.9-1.8-1.6
Condit. Reinf. active minus inactive responses4.75.99.3-3.0-2.4-1.6-2.4
Condit. Reinf. active-inactive response ratio2.93.05.2-2.3-1.7-1.1-1.7
Condit. Reinf. active responses5.88.19.8-3.1-3.0-2.4-2.8
Condit. Reinf. inactive responses2.32.83.6-1.3-1.9-1.8-1.7
Condit. Reinf. lever presses1.41.93.2-1.8-1.4-0.9-1.3
Condit. Reinf. lever reinforcers received4.86.88.3-2.9-2.7-2.2-2.6
Pavlov. Cond. lever latency0.30.40.60.80.60.30.6
Pavlov. Cond. magazine entry latency2.62.93.41.61.81.71.9
Pavlov. Cond. change in total contacts0.50.70.8-0.9-0.9-0.8-0.7
Pavlov. Cond. index score0.10.10.2-0.10.20.40.3
Pavlov. Cond. latency score0.10.20.4-0.00.40.60.4
Pavlov. Cond. lever contacts0.20.30.5-0.7-0.5-0.3-0.5
Pavlov. Cond. magazine entry number3.44.24.9-1.7-2.1-2.1-2.2
Pavlov. Cond. intertrial magazine entries14.919.221.4-4.0-4.5-4.4-4.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.00.30.50.4
Pavlov. Cond. response bias0.00.00.0-0.20.00.10.1
Conditioned reinforcement - actives0.90.91.0-1.0-1.0-0.9-1.0
Conditioned reinforcement - inactives1.01.11.6-1.3-1.0-0.9-1.0
Conditioned locomotion2.53.03.9-2.0-1.6-1.5-1.8
Intermittent access intake day 1-15 change0.30.30.6-0.6-0.5-0.8-0.3
Intermittent access intake escalation0.10.10.2-0.3-0.1-0.4-0.0
Intermittent access intake escalation 20.70.71.0-1.0-0.7-1.0-0.6
Intermitt. access day 1 inactive lever presses3.94.26.1-2.5-2.1-1.6-2.0
Intermitt. access day 15 inactive lever presses2.22.43.0-1.5-1.7-1.3-1.7
Intermitt. access escalation Index3.32.93.21.61.81.61.8
Intermittent access day 1 total infusions0.70.81.2-0.8-1.0-0.6-1.1
Intermittent access day 15 total infusions0.70.80.9-0.8-0.9-0.9-0.9
Intermittent access terminal intake (last 3 days)2.93.23.3-1.8-1.8-1.8-1.8
Intermittent access total infusions3.13.53.9-2.0-1.9-1.6-1.9
Intermittent access day 1 locomotion3.63.74.7-2.2-1.9-1.4-2.1
Intermittent access day 15 total locomotion5.55.98.3-2.9-2.2-2.1-2.4
Intermittent access total locomotion7.88.911.8-3.4-2.8-2.5-3.1
Intermittent access standard deviation1.51.52.3-1.5-1.2-1.0-1.2
Cocaine induced anxiety0.40.51.00.50.71.00.5
Post-drug Anxiety0.70.81.20.80.91.10.7
Baseline Anxiety0.91.01.21.01.10.91.0
Lifetime Intake3.74.14.7-2.1-2.1-1.7-2.2
Incentive Sensitization - Responses3.83.84.1-2.0-1.9-1.9-1.9
Incentive Sensitization - Breakpoint3.43.44.1-2.0-1.7-1.8-1.8
Progressive ratio test 1 active lever presses4.64.85.6-2.4-2.3-1.8-2.3
Progressive ratio test 1 breakpoint6.46.67.6-2.6-2.8-2.2-2.7
Progressive ratio test 1 inactive lever presses5.25.56.5-2.3-2.6-2.0-2.5
Progressive ratio test 2 active lever presses5.45.76.6-2.6-2.4-2.1-2.5
Progressive ratio test 2 breakpoint6.26.97.8-2.8-2.6-2.3-2.8
Progressive ratio test 2 inactive lever presses5.15.96.7-2.4-2.5-2.2-2.6
Total sessions with >9 infusions0.20.20.3-0.4-0.6-0.2-0.6
Short access day 1 total inactive lever presses0.60.61.4-1.2-0.7-0.2-0.8
Short access day 10 total inactive lever presses1.01.11.4-0.6-1.2-1.1-1.1
Short access day 1 total infusions1.31.32.0-1.0-1.4-0.8-1.4
Short access day 10 total infusions6.87.58.6-2.7-2.9-2.4-2.9
Short access total infusions3.84.25.2-2.0-2.3-1.6-2.3
Short access day 1 locomotion3.84.05.1-1.8-2.2-1.7-2.3
Short access day 10 total locomotion12.013.114.9-3.9-3.6-3.3-3.7
Short access total locomotion5.96.06.7-2.6-2.6-2.0-2.6
Compulsive drug intake2.02.02.70.91.61.61.4
One hour access (0.3 mA shock)1.31.51.8-1.2-1.3-1.1-1.2
One hour access (shock baseline)2.32.63.1-1.4-1.7-1.8-1.6
Number of responses in last shaping day0.60.60.8-0.9-0.9-0.3-0.8
Context. condit. distance diff. score0.00.00.10.3-0.2-0.20.0
Locomotion velocity, session 10.60.71.8-1.3-0.5-0.3-0.7
Locomotion distance, session 10.10.10.2-0.40.10.20.1
Locomotion velocity, session 20.40.41.3-1.2-0.4-0.2-0.3
Locomotion distance, session 20.10.10.3-0.50.10.20.2
Locomotion velocity, session 30.60.71.30.40.91.20.7
Locomotion distance, session 30.10.10.2-0.10.40.50.2
Stereotopy head waving bouts, day 30.40.40.70.50.70.80.4
Stereotopy head waving duration, day 30.20.30.40.70.40.50.3
Locomotion velocity, session 70.40.50.70.40.80.70.8
Locomotion distance, session 70.00.00.10.2-0.2-0.30.0
Stereotopy head waving bouts, day 70.60.71.30.40.91.10.7
Stereotopy head waving duration, day 71.92.33.01.01.71.71.5
Locomotion velocity, session 80.80.91.7-1.3-0.7-0.9-0.7
Locomotion distance, session 80.10.10.2-0.2-0.5-0.4-0.3
Degree of sensitization distance0.60.61.3-0.3-0.9-1.1-0.6
Degree of sensitization stereotypy1.41.52.30.61.31.51.3
Condit. Reinf. active minus inactive responses2.83.13.7-1.9-1.9-1.5-1.7
Condit. Reinf. active-inactive response ratio1.31.41.8-1.3-1.3-0.9-1.2
Condit. Reinf. active responses3.74.55.1-2.1-2.3-2.0-2.1
Condit. Reinf. inactive responses1.11.31.4-1.1-1.2-1.2-1.2
Incentive salience index mean2.32.74.5-2.1-1.6-1.1-1.6
Condit. Reinf. lever presses0.30.41.2-1.1-0.4-0.2-0.5
Time in familiar zone, hab. session 11.51.42.6-0.9-1.2-1.6-1.0
Time in novel zone, hab. session 12.12.03.11.31.41.81.2
Total zone transitions, hab. session 10.10.20.7-0.8-0.3-0.1-0.2
Total locomotion distance, hab. session 10.50.72.3-1.5-0.4-0.0-0.6
Locomotion velocity, hab. session 10.81.23.3-1.8-0.7-0.4-0.9
Time in familiar zone, hab. session 22.22.32.8-1.4-1.5-1.7-1.4
Time in novel zone, hab. session 22.52.53.01.51.61.71.5
Total zone transitions, hab. session 20.10.10.2-0.5-0.3-0.3-0.2
Total locomotion distance, hab. session 20.50.60.8-0.9-0.7-0.8-0.8
Locomotion velocity, hab. session 20.40.60.8-0.9-0.6-0.7-0.7
Novel to familiar place preference ratio0.10.10.2-0.4-0.4-0.3-0.5
Novelty place preference0.00.00.1-0.2-0.2-0.0-0.3
Time in novel zone, NPP test0.00.00.0-0.10.00.2-0.1
Total zone transitions, NPP test0.00.10.2-0.5-0.00.20.1
Total locomotion distance, NPP test0.40.51.5-1.2-0.4-0.3-0.5
Locomotion velocity, NPP test0.30.50.8-0.9-0.6-0.5-0.6
Pavlov. Cond. lever latency1.41.84.32.11.00.41.3
Pavlov. Cond. magazine entry latency3.03.86.2-2.5-1.8-1.4-1.9
Pavlov. Cond. change in total contacts2.52.64.3-2.1-1.6-1.0-1.7
Pavlov. Cond. index score2.53.25.5-2.3-1.6-1.1-1.8
Pavlov. Cond. latency score2.02.64.7-2.2-1.4-0.9-1.6
Pavlov. Cond. lever contacts1.31.53.4-1.8-1.0-0.5-1.2
Pavlov. Cond. magazine entry number2.22.84.22.11.61.11.8
Pavlov. Cond. intertrial magazine entries1.82.23.0-0.6-1.7-1.7-1.5
Pavlov. Cond. lever-magazine prob. diff.2.12.64.7-2.2-1.5-0.9-1.7
Pavlov. Cond. response bias2.42.96.0-2.4-1.5-0.8-1.7
Bone: apparent density0.61.02.7-1.6-0.5-0.2-1.0
Bone surface3.56.213.2-3.6-1.9-1.6-2.3
Bone volume2.84.89.5-3.1-1.7-1.4-2.2
Bone: connectivity density1.11.74.0-2.0-0.9-0.7-1.3
Bone: cortical apparent density4.05.27.22.72.12.12.0
Bone: cortical area0.71.12.1-1.5-0.8-0.3-1.2
Bone: cortical porosity5.25.611.7-3.4-1.9-1.3-2.3
Bone: cortical porosity2.73.07.0-2.6-1.3-0.6-1.7
Bone: cortical thickness5.28.612.92.53.03.62.5
Bone: cortical thickness5.16.08.72.12.52.92.3
Bone: cortical tissue density3.74.96.92.62.12.12.0
Bone: elastic displacement2.52.94.60.91.92.21.5
Bone: elastic work0.30.41.0-0.30.71.00.2
Bone: endosteal estimation14.030.337.4-6.1-5.4-5.2-5.3
Bone: endosteal perimeter15.832.539.8-6.3-5.5-5.3-5.6
Bone: final force0.20.41.1-1.0-0.10.2-0.5
Bone: final moment0.20.41.3-1.1-0.00.3-0.6
Bone: marrow area13.629.336.6-6.0-5.3-5.1-5.2
Bone: maximum diameter3.66.59.2-3.0-2.4-2.0-2.7
Bone: maximum force0.81.42.5-1.6-1.0-0.6-1.3
Bone: maximum moment0.81.42.7-1.7-0.9-0.6-1.3
Bone: minimum diameter11.922.027.1-5.2-4.5-4.2-4.7
Bone: periosteal estimation7.916.222.5-4.7-3.8-3.3-4.1
Bone: periosteal perimeter3.76.110.4-3.2-2.1-1.7-2.5
Bone: post-yield work2.02.84.4-2.1-1.5-1.4-1.5
Bone: stiffness0.50.81.2-1.1-0.8-0.8-0.8
Bone: tissue strength1.61.52.00.81.31.31.4
Bone: trabecular number1.21.84.3-2.1-0.9-0.7-1.3
Bone: trabecular spacing0.20.30.90.90.0-0.10.4
Bone: trabecular thickness1.31.63.4-1.8-0.9-0.6-1.4
Bone: trabecular tissue density1.42.02.31.31.51.51.4
Breakpoint value in progressive ratio session1.01.11.5-1.0-1.2-0.9-1.1
Distance traveled before self-admin0.60.60.90.70.61.00.8
Distance traveled after self-admin0.10.10.20.10.30.50.4
Delta time in closed arm before/after self-admin0.20.20.3-0.40.50.40.4
Delta time in open arm before/after self-admin0.40.41.21.1-0.4-0.4-0.1
Diff in mean of infusions in LGA sessions0.80.91.41.20.80.90.9
Extinction: sum of active levers before priming0.80.81.2-0.3-1.1-1.1-0.9
Active lever presses in extinction session 62.32.22.6-1.4-1.6-1.4-1.6
Delta distance traveled before/after self-admin0.10.10.20.30.30.50.3
Delta ambulatory time before/after self-admin0.00.00.1-0.3-0.1-0.1-0.2
Time in closed arm before self-admin1.31.52.60.91.31.61.1
Time in closed arm after self-admin1.41.52.40.31.51.41.2
Time in open arm before self-admin0.70.81.10.41.00.91.0
Time in open arm after self-admin0.50.60.90.2-0.9-1.0-0.6
Sum of active levers in priming session hrs 5-60.20.20.60.8-0.3-0.1-0.0
Time to tail flick, vehicle, before self-admin0.60.60.90.30.90.80.9
Time to tail flick, vehicle, after self-admin0.80.91.2-0.3-1.0-1.1-1.1
Time to tail flick, test, before self-admin0.60.61.00.70.80.51.0
Time to tail flick, test, after self-admin0.20.20.30.50.40.50.2
Delta time to tail flick, vehicle, before/after SA3.43.34.2-1.2-2.0-2.0-2.0
Delta time to tail flick, test, before/after SA0.10.00.10.1-0.1-0.0-0.4
Ambulatory time before self-admin0.30.30.50.40.40.70.6
Ambulatory time after self-admin0.00.00.1-0.3-0.00.2-0.0
Total heroin consumption0.20.20.5-0.7-0.5-0.1-0.3
Area under the delay curve0.00.00.1-0.2-0.1-0.2-0.2
Delay disc. indifference point, 0s delay0.50.61.31.20.70.50.6
Delay disc. indifference point, 16s delay0.20.20.3-0.3-0.5-0.4-0.5
Delay disc. indifference point, 2s delay0.30.30.4-0.7-0.3-0.5-0.6
Delay disc. indifference point, 24s delay1.91.81.9-1.3-1.3-1.4-1.4
Delay disc. indifference point, 4s delay1.11.21.60.81.31.21.1
Delay disc. indifference point, 8s delay0.10.20.20.40.40.40.2
Delay discount exponential model param0.20.20.30.50.20.40.4
Delay discount hyperbolic model param0.10.10.10.30.10.30.3
Fecal boli incidents, locomotor time 10.10.10.20.2-0.3-0.4-0.1
Change in fecal boli incidents, locomotor task0.30.30.50.40.40.30.7
Time >=10cm from walls, locomotor time 13.23.24.01.61.71.82.0
Bouts of movement, locomotor time 10.20.30.60.80.40.40.3
Total resting periods, locomotor time 10.30.40.70.90.60.50.5
Rest time, locomotor task time 10.10.10.30.50.20.30.4
Distance moved, locomotor task time 10.50.51.2-1.1-0.4-0.6-0.7
Vertical activity count, locomotor time 10.20.20.7-0.8-0.0-0.1-0.3
Time >=10cm from walls, locomotor time 20.40.40.80.20.50.90.6
Bouts of movement, locomotor time 20.30.31.21.10.10.10.2
Total resting periods, locomotor time 20.60.61.91.40.40.40.5
Rest time, locomotor task time 23.13.66.42.51.61.51.8
Distance moved, locomotor task time 20.50.51.7-1.3-0.1-0.2-0.6
Vertical activity count, locomotor time 22.73.04.8-2.2-1.5-1.3-1.8
Weight adjusted by age0.50.61.31.10.50.40.7
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.2-0.4-0.5-0.2
Locomotion in novel chamber0.40.50.8-0.30.90.70.8
Locomotion in novel chamber post-restriction1.61.92.3-1.3-1.3-1.4-1.5
Progressive ratio0.00.00.10.20.4-0.1-0.0
Food seeking constrained by brief footshock4.25.16.4-2.5-2.1-2.3-2.1
Seeking ratio, punishment vs. effort1.51.92.6-1.6-1.4-1.2-1.1
Run reversals in cocaine runway, females0.40.40.50.70.60.70.6
Run reversals in cocaine runway, males0.30.20.30.50.40.50.6
Latency to leave start box in cocaine runway0.50.60.70.80.60.80.8
Latency to leave start box in cocaine runway, F1.41.62.31.01.21.51.2
Latency to leave start box in cocaine runway, M0.10.10.20.1-0.3-0.4-0.1
Cd content in liver2.42.63.31.81.61.11.8
Co content in liver0.10.10.10.30.30.00.4
Cu content in liver0.30.40.5-0.3-0.7-0.7-0.7
Fe content in liver0.20.20.40.70.30.40.5
K content in liver0.80.81.1-1.0-0.8-0.9-0.9
Mg content in liver0.20.20.5-0.0-0.4-0.7-0.5
Mn content in liver0.00.10.1-0.10.30.30.1
Na content in liver0.50.50.8-0.5-0.8-0.6-0.9
Rb content in liver2.83.54.41.91.91.62.1
Se content in liver0.81.01.71.30.90.70.9
Sr content in liver0.20.20.6-0.8-0.10.1-0.4
Zn content in liver0.00.10.1-0.40.10.2-0.2