Hub : Genes

Usp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000054863	0.11	0.08	5.0e-05	0.03	0.04	0.04	0.04	4.9e-04	7.9e-05	1.7e-05	4.4e-05
2	Adipose	isoform ratio	ENSRNOT00000083046	0.05	0.03	3.5e-06	0.04	0.04	0.03	0.04	4.1e-05	2.1e-05	8.1e-04	5.9e-05
3	Adipose	isoform ratio	ENSRNOT00000085609	0.05	0.04	3.0e-06	0.04	0.04	0.03	0.04	4.0e-05	1.9e-05	7.9e-04	5.2e-05
4	Adipose	intron excision ratio	chr8:109050099:109053810	0.04	0.02	5.1e-05	0.03	0.03	0.02	0.03	9.2e-05	2.9e-04	6.0e-03	4.3e-04
5	Liver	gene expression	ENSRNOG00000054863	0.04	0.03	5.0e-05	0.02	0.02	0.01	0.02	1.6e-03	1.2e-03	3.3e-02	4.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.1	0.4	1.0	0.3	-0.5	0.6	1.0	0.7
BMI without tail	0.0	0.1	0.3	-0.6	0.2	-0.2	0.1	-0.2
Body weight	0.5	2.0	8.1	-2.9	-0.6	0.6	1.0	0.5
Epididymis fat weight	0.0	0.1	0.2	-0.1	-0.2	0.2	0.4	0.3
Glucose	1.8	2.8	6.2	-2.5	1.4	-1.4	-1.4	-1.4
Heart weight	0.8	1.1	2.2	-0.9	-0.9	0.9	1.5	1.0
Left kidney weight	0.9	2.6	3.0	-1.7	1.7	-1.7	-1.3	-1.6
Right kidney weight	1.0	2.9	3.3	-1.8	1.8	-1.8	-1.5	-1.7
Tail length	1.4	4.2	16.9	-4.1	1.0	-0.9	-1.0	-1.2
Length with tail	1.5	5.6	26.4	-5.1	0.5	-0.5	-0.4	-0.8
Length without tail	1.0	2.1	10.5	-3.2	-0.2	0.2	0.3	-0.0
Liver weight, left	1.2	2.0	3.2	-0.4	1.4	-1.4	-1.8	-1.6
Liver weight, right	2.0	3.3	5.4	-2.3	1.7	-1.7	-1.6	-1.7
Parametrial fat weight	0.3	0.6	0.7	-0.8	0.7	-0.7	-0.9	-0.8
Retroperitoneal fat weight	0.2	0.7	0.9	-0.2	1.0	-1.0	-0.8	-0.9
Intraocular pressure	1.5	2.0	4.0	-2.0	1.2	-1.2	-1.3	-1.3
Extensor digitorum longus weight	0.3	1.3	1.5	1.0	-1.2	1.2	1.2	1.2
Soleus weight	0.5	1.3	6.7	-2.6	-0.0	0.1	0.2	-0.1
Tibialis anterior weight	0.2	0.6	0.8	0.1	-0.8	0.8	0.9	0.9
Tibia length	1.4	4.1	19.8	-4.4	0.4	-0.3	-0.2	-0.5
Number of licking bursts	2.5	2.9	3.4	1.4	-1.8	1.8	1.6	1.7
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.4	0.1	-0.1	0.1	-0.1
Times rat made contact with spout	0.1	0.1	0.2	-0.3	-0.4	0.4	0.3	0.3
Mean time between licks in bursts	0.4	0.6	2.4	1.5	-0.4	0.3	0.4	0.4
Mean num. licks in bursts	2.5	3.0	3.1	-1.7	1.8	-1.8	-1.6	-1.7
Std. dev. time between licks in bursts	4.3	5.1	5.8	2.4	-2.1	2.1	2.3	2.3
Water consumed over 24 hours	1.6	1.9	2.3	0.8	-1.5	1.5	1.5	1.5
Indifference point 0 sec	1.8	2.9	3.5	-0.8	1.8	-1.8	-1.8	-1.9
Indifference point AUC	1.5	1.7	3.4	-1.8	1.0	-1.0	-1.3	-1.1
Indifference point function ln k	0.7	1.0	4.6	2.1	-0.1	0.1	0.6	0.4
Indifference point function log k	0.7	1.0	4.6	2.1	-0.1	0.1	0.6	0.4
Delay discounting total patch changes 0 sec	1.2	1.9	2.3	-0.8	1.5	-1.5	-1.5	-1.5
Delay discounting total patch changes 12 sec	0.7	0.9	2.3	-1.5	0.7	-0.7	-0.9	-0.8
Delay discounting total patch changes 18 sec	2.1	2.8	3.6	-1.8	1.5	-1.5	-1.9	-1.7
Delay discounting total patch changes 24 sec	0.6	0.8	2.9	-1.7	0.5	-0.5	-0.5	-0.6
Delay discounting total patch changes 6 sec	1.8	2.7	4.0	-1.0	1.7	-1.7	-2.0	-1.8
Delay discounting time to switch 0 sec	1.2	1.8	2.1	1.1	-1.4	1.4	1.3	1.4
Delay discounting water rate 0 sec	0.0	0.0	0.1	-0.0	0.2	-0.2	-0.2	-0.3
Delay discounting water rate 12 sec	0.0	0.0	0.0	0.2	0.0	-0.0	0.1	-0.0
Delay discounting water rate 18 sec	0.8	1.0	1.6	-0.6	-1.0	1.0	1.2	1.1
Delay discounting water rate 24 sec	0.1	0.2	0.7	-0.8	-0.0	0.0	0.2	0.0
Delay discounting water rate 6 sec	0.2	0.3	0.6	-0.8	0.5	-0.5	-0.4	-0.4
Locomotor activity	1.6	2.6	8.5	-2.9	1.2	-1.2	-0.7	-1.2
Locomotor testing distance	1.7	2.9	8.3	-2.9	1.4	-1.3	-0.8	-1.3
Locomotor testing rearing	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1	-0.2
Light reinforcement 1	0.2	0.4	1.7	-1.3	0.0	-0.0	-0.1	-0.1
Light reinforcement 2	0.4	0.5	0.7	-0.8	0.7	-0.7	-0.8	-0.7
Reaction time number correct	0.2	0.3	0.3	-0.3	-0.6	0.6	0.4	0.6
Reaction time mean minus median	0.4	0.5	2.2	-1.5	0.3	-0.3	-0.2	-0.3
Reaction time mean minus median AUC	0.7	0.9	3.3	-1.8	0.5	-0.5	-0.6	-0.6
Reaction time num false alarms	0.2	0.3	0.5	-0.2	0.7	-0.7	-0.2	-0.5
Reaction time num false alarms AUC	0.6	0.8	1.2	-0.5	1.1	-1.1	-0.6	-0.9
Reaction time trials correct on left	0.2	0.3	0.3	-0.3	-0.6	0.6	0.4	0.6
Reaction time trials on left	0.2	0.2	0.3	-0.3	-0.5	0.5	0.4	0.6
Reaction time mean	0.2	0.2	0.3	0.2	0.5	-0.5	-0.5	-0.5
Reaction time mean AUC	0.3	0.4	0.6	0.2	0.7	-0.7	-0.7	-0.8
Median of all reaction times	0.2	0.3	0.4	0.7	0.5	-0.5	-0.5	-0.5
Reaction time omissions	0.0	0.1	0.2	0.5	0.0	-0.0	-0.2	-0.1
Reaction time false alarm rate	0.4	0.6	1.0	-0.1	1.0	-1.0	-0.5	-0.8
Reaction time premature initiation rate	0.2	0.3	0.8	-0.9	0.2	-0.2	-0.5	-0.3
Reaction time premature initiations	0.1	0.2	0.8	-0.9	-0.2	0.2	-0.1	0.1
Std. dev. reaction times	0.7	0.9	1.1	-1.0	0.9	-0.9	-0.9	-1.0
Reaction time trials completed	0.2	0.2	0.3	-0.3	-0.5	0.5	0.4	0.6
Reaction time trials AUC	0.2	0.2	0.3	-0.2	-0.6	0.5	0.4	0.6
Social response proportion	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.2	0.0
Social responses	0.8	1.1	4.3	-2.1	0.5	-0.5	-0.5	-0.5
Social time	2.3	3.0	3.8	0.7	-1.8	1.8	1.9	1.9
Conditioned locomotion	0.3	0.3	0.9	0.9	0.3	-0.3	-0.6	-0.3
Cocaine response after cond. corrected	2.1	2.3	2.9	-0.5	-1.7	1.7	1.7	1.6
Cocaine response after cond. not corrected	1.3	1.5	3.1	-1.7	-1.0	1.0	1.2	1.0
Cocaine response before conditioning	1.7	2.0	3.3	-1.8	1.4	-1.4	-1.1	-1.3
Saline control response	3.3	4.4	5.2	-1.5	2.2	-2.2	-2.3	-2.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.5	-0.2	0.2	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.6	-0.6	0.6	0.6	0.6
Condit. Reinf. active responses	0.0	0.1	0.3	-0.5	-0.1	0.1	-0.1	0.0
Condit. Reinf. inactive responses	0.1	0.1	0.4	0.6	0.1	-0.1	-0.3	-0.2
Condit. Reinf. lever presses	0.4	0.5	2.4	-1.6	-0.1	0.1	0.2	0.1
Condit. Reinf. lever reinforcers received	0.0	0.1	0.3	-0.5	-0.1	0.1	-0.1	0.0
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.6	0.1	-0.1	-0.2	-0.1
Pavlov. Cond. magazine entry latency	0.4	0.4	0.6	-0.3	-0.7	0.7	0.8	0.7
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.7	-0.5	0.5	0.4	0.4
Pavlov. Cond. index score	0.3	0.4	0.7	-0.3	-0.7	0.7	0.9	0.7
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.1	-0.6	0.6	0.8	0.7
Pavlov. Cond. lever contacts	0.3	0.4	1.8	-1.3	0.4	-0.4	-0.2	-0.3
Pavlov. Cond. magazine entry number	0.4	0.6	0.7	-0.2	0.8	-0.8	-0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.5	0.7	3.3	1.8	0.1	-0.1	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	-0.3	-0.7	0.7	0.9	0.8
Pavlov. Cond. response bias	0.2	0.3	0.4	-0.6	-0.4	0.4	0.6	0.5
Conditioned reinforcement - actives	0.1	0.1	0.1	-0.4	0.3	-0.3	-0.2	-0.2
Conditioned reinforcement - inactives	3.2	3.7	4.6	1.0	-2.1	2.0	2.1	2.1
Conditioned locomotion	0.7	0.8	1.2	-0.3	1.0	-1.0	-1.1	-0.9
Intermittent access intake day 1-15 change	2.9	2.9	3.8	1.4	-1.7	1.7	2.0	1.7
Intermittent access intake escalation	2.3	2.3	2.9	1.4	-1.5	1.5	1.7	1.5
Intermittent access intake escalation 2	3.1	3.1	3.5	1.7	-1.7	1.7	1.9	1.7
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.6	-0.8	-0.2	0.2	0.2	0.1
Intermitt. access day 15 inactive lever presses	2.5	2.8	3.1	1.6	-1.7	1.7	1.5	1.7
Intermitt. access escalation Index	0.4	0.4	0.7	0.4	0.5	-0.5	-0.8	-0.6
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.3	-0.1
Intermittent access day 15 total infusions	0.6	0.7	0.9	1.0	-0.8	0.8	0.8	0.8
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	0.8	-0.5	0.5	0.3	0.4
Intermittent access total infusions	0.2	0.2	0.5	0.7	-0.3	0.3	0.3	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.1	0.2	-0.2	-0.5	-0.2
Intermittent access day 15 total locomotion	0.3	0.3	0.5	0.2	0.6	-0.6	-0.7	-0.6
Intermittent access total locomotion	0.4	0.4	0.7	0.5	0.6	-0.6	-0.8	-0.6
Intermittent access standard deviation	3.1	3.3	4.2	0.7	-2.1	2.1	2.0	2.0
Cocaine induced anxiety	0.5	0.6	0.9	0.4	-0.8	0.8	1.0	0.8
Post-drug Anxiety	0.2	0.2	0.3	0.2	-0.5	0.5	0.6	0.5
Baseline Anxiety	0.1	0.1	0.2	0.1	0.5	-0.5	-0.2	-0.3
Lifetime Intake	0.0	0.0	0.2	0.4	0.0	-0.0	-0.0	0.0
Incentive Sensitization - Responses	0.9	0.9	1.2	1.1	-0.9	0.9	1.0	1.0
Incentive Sensitization - Breakpoint	0.9	0.9	1.2	1.1	-0.9	0.9	1.0	1.0
Progressive ratio test 1 active lever presses	0.7	0.8	1.0	-0.3	1.0	-1.0	-1.0	-1.0
Progressive ratio test 1 breakpoint	0.8	0.8	1.0	-0.3	1.0	-1.0	-1.0	-1.0
Progressive ratio test 1 inactive lever presses	0.9	0.9	1.1	0.7	-1.0	1.0	1.0	1.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.6	-0.1	0.1	0.1	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.6	-0.2	0.2	0.2	0.2
Progressive ratio test 2 inactive lever presses	3.9	4.4	4.9	2.2	-2.1	2.1	2.1	2.1
Total sessions with >9 infusions	1.3	1.4	1.8	0.6	-1.3	1.3	1.2	1.3
Short access day 1 total inactive lever presses	1.0	1.1	1.5	1.2	-0.9	0.9	1.2	1.1
Short access day 10 total inactive lever presses	3.8	4.1	5.9	0.3	-2.4	2.4	2.0	2.2
Short access day 1 total infusions	0.4	0.4	0.4	0.6	-0.6	0.6	0.5	0.7
Short access day 10 total infusions	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.4	-0.3
Short access total infusions	0.1	0.1	0.2	0.4	0.3	-0.3	-0.4	-0.3
Short access day 1 locomotion	0.2	0.2	0.3	0.2	-0.6	0.6	-0.0	0.4
Short access day 10 total locomotion	0.8	0.8	1.3	-0.7	0.9	-0.9	-1.1	-0.9
Short access total locomotion	1.0	1.0	1.5	-0.8	1.0	-1.0	-1.2	-1.0
Compulsive drug intake	0.8	0.8	1.5	-0.1	0.9	-0.9	-1.2	-0.9
One hour access (0.3 mA shock)	0.2	0.2	0.5	0.2	0.4	-0.4	-0.7	-0.5
One hour access (shock baseline)	0.1	0.1	0.2	0.5	-0.4	0.4	0.3	0.3
Number of responses in last shaping day	1.0	1.0	1.2	0.7	-1.1	1.1	1.0	1.1
Context. condit. distance diff. score	0.0	0.1	0.1	-0.2	-0.2	0.2	0.3	0.3
Locomotion velocity, session 1	0.5	0.5	2.1	-1.4	0.4	-0.4	-0.4	-0.4
Locomotion distance, session 1	1.5	1.9	5.3	-2.3	1.1	-1.1	-0.9	-1.0
Locomotion velocity, session 2	0.2	0.2	0.4	-0.5	-0.2	0.2	0.6	0.4
Locomotion distance, session 2	0.7	1.0	1.3	-1.0	1.1	-1.1	-0.7	-0.9
Locomotion velocity, session 3	1.1	1.3	1.7	-0.8	1.3	-1.3	-1.0	-1.1
Locomotion distance, session 3	0.4	0.4	0.6	0.7	0.8	-0.8	-0.5	-0.5
Stereotopy head waving bouts, day 3	2.1	2.5	2.9	1.1	-1.7	1.7	1.7	1.6
Stereotopy head waving duration, day 3	0.4	0.5	0.8	0.4	-0.9	0.9	0.6	0.7
Locomotion velocity, session 7	1.8	2.0	2.3	-1.1	1.4	-1.4	-1.5	-1.4
Locomotion distance, session 7	0.4	0.5	0.6	0.2	0.8	-0.8	-0.7	-0.7
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	-0.3	0.5	-0.5	-0.5	-0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.8	-0.9	0.5	-0.5	-0.6	-0.5
Locomotion velocity, session 8	0.8	0.9	2.3	-1.5	0.8	-0.8	-0.7	-0.7
Locomotion distance, session 8	2.1	3.2	4.3	-2.1	1.8	-1.8	-1.4	-1.6
Degree of sensitization distance	0.3	0.3	1.4	-1.2	0.0	-0.0	-0.4	-0.2
Degree of sensitization stereotypy	1.3	1.4	1.5	-1.2	1.2	-1.2	-1.2	-1.2
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	0.6	-1.0	1.0	0.6	0.8
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.8	0.4	-1.3	1.3	1.0	1.2
Condit. Reinf. active responses	0.5	0.6	0.8	0.8	-0.9	0.9	0.6	0.8
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1	-0.1
Incentive salience index mean	0.4	0.5	0.7	0.5	-0.9	0.9	0.6	0.8
Condit. Reinf. lever presses	0.3	0.5	0.7	0.8	-0.6	0.6	0.5	0.7
Time in familiar zone, hab. session 1	1.4	1.3	1.7	1.3	-1.2	1.2	0.9	1.1
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.5	0.3	-0.3	-0.2	-0.3
Total zone transitions, hab. session 1	1.1	1.5	1.8	-1.3	1.3	-1.3	-1.0	-1.2
Total locomotion distance, hab. session 1	0.4	0.6	0.8	-0.9	0.8	-0.8	-0.6	-0.7
Locomotion velocity, hab. session 1	0.7	1.0	1.1	-1.1	1.0	-1.0	-0.9	-1.0
Time in familiar zone, hab. session 2	1.5	1.6	2.1	0.4	-1.4	1.4	1.3	1.4
Time in novel zone, hab. session 2	0.8	0.8	1.0	0.4	1.0	-1.0	-1.0	-1.0
Total zone transitions, hab. session 2	0.1	0.2	0.3	-0.6	0.4	-0.4	0.0	-0.2
Total locomotion distance, hab. session 2	0.4	0.5	0.7	-0.9	0.7	-0.7	-0.5	-0.6
Locomotion velocity, hab. session 2	0.4	0.6	0.9	-0.9	0.8	-0.8	-0.6	-0.7
Novel to familiar place preference ratio	8.0	8.4	9.4	-2.2	3.1	-3.1	-3.0	-3.0
Novelty place preference	9.1	9.5	10.6	-2.4	3.3	-3.3	-3.2	-3.2
Time in novel zone, NPP test	7.8	8.2	9.1	-2.2	3.0	-3.0	-3.0	-3.0
Total zone transitions, NPP test	2.9	4.2	7.8	-2.8	2.0	-2.0	-1.4	-1.8
Total locomotion distance, NPP test	0.7	1.0	2.0	-1.4	1.0	-0.9	-0.6	-0.9
Locomotion velocity, NPP test	1.2	1.7	3.0	-1.7	1.3	-1.3	-0.9	-1.2
Pavlov. Cond. lever latency	1.5	1.9	3.1	-1.8	1.2	-1.2	-1.4	-1.4
Pavlov. Cond. magazine entry latency	3.6	4.6	8.5	2.9	-1.9	1.8	1.9	2.0
Pavlov. Cond. change in total contacts	2.0	2.1	3.3	1.8	-1.5	1.5	1.1	1.4
Pavlov. Cond. index score	3.5	4.5	7.9	2.8	-1.9	1.9	1.9	2.0
Pavlov. Cond. latency score	2.7	3.4	6.1	2.5	-1.6	1.6	1.6	1.8
Pavlov. Cond. lever contacts	1.2	1.4	2.1	1.4	-1.1	1.1	1.1	1.2
Pavlov. Cond. magazine entry number	3.5	4.4	9.6	-3.1	1.8	-1.7	-1.7	-1.9
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.4	-0.4	0.6	-0.6	-0.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	4.6	5.8	8.9	3.0	-2.2	2.2	2.2	2.3
Pavlov. Cond. response bias	4.5	5.5	9.6	3.1	-2.1	2.1	2.1	2.2
Bone: apparent density	0.9	1.5	1.9	-0.8	1.3	-1.3	-1.4	-1.3
Bone surface	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.0	-0.0
Bone volume	0.1	0.3	0.5	-0.7	0.4	-0.4	-0.4	-0.4
Bone: connectivity density	1.5	2.4	3.4	0.0	1.7	-1.7	-1.9	-1.7
Bone: cortical apparent density	0.1	0.2	0.3	0.2	0.4	-0.5	-0.6	-0.5
Bone: cortical area	2.6	4.0	5.1	0.5	-2.2	2.2	2.3	2.2
Bone: cortical porosity	2.3	2.5	3.5	-0.8	1.7	-1.7	-1.9	-1.7
Bone: cortical porosity	2.6	2.8	3.7	-0.7	1.8	-1.8	-1.9	-1.8
Bone: cortical thickness	3.1	5.1	6.5	0.3	-2.5	2.5	2.5	2.5
Bone: cortical thickness	0.1	0.2	0.2	-0.4	-0.4	0.4	0.4	0.4
Bone: cortical tissue density	0.2	0.3	0.4	0.1	0.6	-0.6	-0.7	-0.6
Bone: elastic displacement	0.8	0.9	1.0	0.8	-1.0	1.0	1.0	1.0
Bone: elastic work	0.9	1.1	1.4	-0.3	-1.2	1.2	1.2	1.1
Bone: endosteal estimation	0.4	0.8	1.0	-0.9	0.8	-0.8	-1.0	-0.9
Bone: endosteal perimeter	0.0	0.0	0.0	0.2	-0.0	0.0	0.2	0.1
Bone: final force	1.1	1.8	2.2	-0.8	-1.5	1.5	1.4	1.4
Bone: final moment	1.3	2.2	2.6	-0.9	-1.6	1.6	1.6	1.5
Bone: marrow area	0.4	0.9	1.0	-1.0	0.9	-0.9	-1.0	-0.9
Bone: maximum diameter	1.3	2.5	3.2	0.3	-1.7	1.7	1.8	1.8
Bone: maximum force	0.4	0.7	0.9	-1.0	-0.9	0.9	0.7	0.7
Bone: maximum moment	0.5	0.9	1.0	-0.9	-1.0	1.0	0.9	0.9
Bone: minimum diameter	0.2	0.3	0.6	0.2	-0.6	0.5	0.8	0.7
Bone: periosteal estimation	0.2	0.4	0.4	-0.5	-0.7	0.7	0.6	0.6
Bone: periosteal perimeter	0.5	0.8	1.1	0.4	-0.9	0.9	1.1	1.0
Bone: post-yield work	0.0	0.0	0.0	-0.2	0.0	-0.0	-0.1	-0.1
Bone: stiffness	0.1	0.2	0.7	-0.8	-0.2	0.2	0.0	0.1
Bone: tissue strength	0.9	0.9	1.3	-0.0	-1.1	1.1	1.0	1.0
Bone: trabecular number	1.1	1.8	2.3	-0.1	1.5	-1.5	-1.5	-1.4
Bone: trabecular spacing	1.4	1.8	2.4	0.5	-1.5	1.5	1.5	1.4
Bone: trabecular thickness	1.5	1.9	2.0	-1.4	1.4	-1.4	-1.3	-1.3
Bone: trabecular tissue density	0.3	0.4	0.9	-0.9	0.5	-0.5	-0.6	-0.6
Breakpoint value in progressive ratio session	0.3	0.3	0.5	-0.6	0.5	-0.5	-0.7	-0.6
Distance traveled before self-admin	0.9	1.0	1.5	0.1	-1.0	1.0	1.2	1.1
Distance traveled after self-admin	0.5	0.5	0.6	0.6	-0.8	0.8	0.7	0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.4	-0.1	0.1	-0.4	-0.0
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.6	0.3	-0.3	-0.4	-0.4
Diff in mean of infusions in LGA sessions	2.4	2.6	3.1	1.3	-1.7	1.7	1.8	1.7
Extinction: sum of active levers before priming	1.1	1.1	1.3	-0.9	1.1	-1.1	-0.9	-1.1
Active lever presses in extinction session 6	1.4	1.3	1.9	-1.2	1.0	-1.0	-1.4	-1.1
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.4	0.3	-0.3	-0.5	-0.4
Delta ambulatory time before/after self-admin	0.3	0.4	0.6	-0.4	0.6	-0.6	-0.8	-0.7
Time in closed arm before self-admin	0.2	0.2	1.1	1.0	-0.1	0.1	0.0	-0.0
Time in closed arm after self-admin	0.3	0.3	0.6	0.8	-0.5	0.5	0.3	0.5
Time in open arm before self-admin	0.1	0.1	0.1	-0.1	-0.2	0.2	0.3	0.3
Time in open arm after self-admin	1.6	1.8	2.4	-1.1	1.3	-1.3	-1.6	-1.4
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.2	-1.1	0.8	-0.8	-0.7	-0.8
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.4	-1.2	0.5	-0.5	-0.4	-0.5
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.3	-0.5	-0.4	0.4	1.1	0.6
Time to tail flick, test, before self-admin	1.6	1.6	2.5	-0.3	1.3	-1.3	-1.6	-1.4
Time to tail flick, test, after self-admin	0.4	0.4	0.6	0.8	-0.6	0.6	0.8	0.6
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.9	1.0	-0.8	0.8	1.4	1.0
Delta time to tail flick, test, before/after SA	1.0	0.9	1.1	1.1	-0.9	0.9	1.0	0.9
Ambulatory time before self-admin	1.1	1.1	1.4	0.9	-1.1	1.1	1.2	1.1
Ambulatory time after self-admin	0.0	0.0	0.0	0.2	-0.0	0.0	-0.2	-0.0
Total heroin consumption	0.1	0.1	0.4	-0.5	-0.1	0.1	0.6	0.2
Area under the delay curve	0.5	0.5	0.6	0.8	0.7	-0.7	-0.8	-0.6
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.1	-0.2	0.2	-0.4	0.0
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	0.9	0.4	-0.4	-0.6	-0.4
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.3	-0.1
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.7	0.5	-0.5	-0.5	-0.4
Delay disc. indifference point, 4s delay	0.2	0.3	0.9	0.9	-0.4	0.4	-0.0	0.3
Delay disc. indifference point, 8s delay	0.6	0.6	1.0	0.5	1.0	-1.0	-0.7	-0.8
Delay discount exponential model param	0.4	0.4	0.9	-0.9	-0.6	0.6	0.6	0.5
Delay discount hyperbolic model param	0.4	0.4	0.8	-0.9	-0.6	0.6	0.6	0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.6	0.0	-0.0	0.2	0.0
Change in fecal boli incidents, locomotor task	0.2	0.2	0.2	-0.1	0.4	-0.4	-0.5	-0.4
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.2	0.6	1.1	-1.1	-0.8	-0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.3	-0.3	0.3	0.1	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.3	-0.2	0.2	0.1	0.2
Rest time, locomotor task time 1	0.1	0.1	0.4	0.6	-0.1	0.1	-0.2	0.0
Distance moved, locomotor task time 1	0.2	0.3	0.9	-1.0	-0.1	0.1	0.5	0.2
Vertical activity count, locomotor time 1	0.5	0.5	1.9	-1.4	0.5	-0.5	0.1	-0.4
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.8	-0.9	0.5	-0.5	-0.4	-0.5
Bouts of movement, locomotor time 2	0.6	0.7	1.0	-0.0	-1.0	1.0	0.8	0.9
Total resting periods, locomotor time 2	0.5	0.6	0.8	0.1	-0.9	0.9	0.7	0.8
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.5	-0.0	0.0	-0.4	-0.1
Distance moved, locomotor task time 2	0.1	0.2	0.6	-0.8	0.1	-0.1	0.5	0.1
Vertical activity count, locomotor time 2	0.2	0.3	0.6	-0.8	0.5	-0.5	0.1	-0.3
Weight adjusted by age	0.5	0.6	1.2	-0.6	-0.7	0.7	1.1	0.8
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	0.7	0.6	-0.6	-0.6	-0.5
Locomotion in novel chamber	0.7	0.9	1.2	0.6	-1.1	1.1	0.8	1.0
Locomotion in novel chamber post-restriction	0.8	1.0	1.0	-1.0	1.0	-1.0	-1.0	-1.0
Progressive ratio	3.0	3.5	11.5	-3.4	1.2	-1.2	-1.1	-1.3
Food seeking constrained by brief footshock	0.3	0.3	0.4	0.7	-0.6	0.6	0.4	0.6
Seeking ratio, punishment vs. effort	3.6	4.4	13.5	3.7	-1.4	1.4	1.5	1.6
Run reversals in cocaine runway, females	1.0	1.0	3.2	1.8	-0.5	0.5	1.0	0.7
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.2	-0.4	0.4	0.8	0.5
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.6	-0.2	0.2	0.0	0.1
Latency to leave start box in cocaine runway, F	0.6	0.7	1.0	-0.4	-0.9	0.9	1.0	0.8
Latency to leave start box in cocaine runway, M	0.6	0.5	1.2	-0.4	0.6	-0.6	-1.1	-0.7
Cd content in liver	0.4	0.4	0.6	-0.5	-0.8	0.8	0.4	0.5
Co content in liver	1.1	1.3	1.6	1.3	-1.1	1.1	1.1	1.1
Cu content in liver	1.5	1.8	3.7	-1.9	1.1	-1.0	-1.3	-1.3
Fe content in liver	0.2	0.2	0.4	-0.2	-0.6	0.6	0.1	0.3
K content in liver	0.6	0.6	1.6	-1.3	0.7	-0.7	-0.5	-0.6
Mg content in liver	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.1	-0.3
Mn content in liver	2.0	2.3	2.9	-1.7	1.5	-1.5	-1.4	-1.5
Na content in liver	0.8	0.8	1.2	-0.6	0.8	-0.8	-1.1	-1.0
Rb content in liver	0.5	0.7	1.1	0.7	-1.0	1.0	0.5	0.7
Se content in liver	0.1	0.1	0.5	-0.7	0.0	-0.0	0.1	0.0
Sr content in liver	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.0	-0.2
Zn content in liver	1.4	1.5	4.5	-2.1	0.8	-0.8	-0.9	-1.0