Hub : Genes

Cers5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	intron excision ratio	chr7:130870888:130871949	0.26	0.18	1.1e-03	0.09	0.2	0.12	0.1	1.6e-02	5.8e-04	6.3e-03	1.4e-02
2	Eye	intron excision ratio	chr7:130872079:130876061	0.21	0.16	4.2e-03	0.12	0.16	0.14	0.16	7.5e-03	2.0e-03	4.1e-03	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	4.4	14.2	14.9	3.9	-3.7
BMI without tail	0.2	0.4	0.5	0.5	-0.7
Body weight	5.5	23.3	23.7	4.8	-4.9
Epididymis fat weight	0.0	0.0	0.1	0.2	-0.0
Glucose	0.4	0.6	0.9	-0.5	1.0
Heart weight	0.1	0.1	0.1	0.3	-0.3
Left kidney weight	1.1	3.2	3.9	1.6	-2.0
Right kidney weight	2.7	7.6	8.8	2.5	-3.0
Tail length	0.0	0.1	0.1	-0.3	-0.2
Length with tail	2.0	7.5	8.4	2.6	-2.9
Length without tail	5.4	11.9	12.3	3.5	-3.4
Liver weight, left	1.6	2.6	2.9	1.7	-1.5
Liver weight, right	1.6	2.7	2.7	1.6	-1.7
Parametrial fat weight	1.7	3.4	3.7	-1.8	1.9
Retroperitoneal fat weight	1.2	4.0	4.6	-1.9	2.1
Intraocular pressure	5.1	7.2	8.3	-2.9	2.5
Extensor digitorum longus weight	4.9	19.5	20.1	4.4	-4.5
Soleus weight	1.1	3.1	3.2	1.7	-1.8
Tibialis anterior weight	2.8	9.7	10.8	2.9	-3.3
Tibia length	5.0	14.1	14.5	3.8	-3.7
Number of licking bursts	1.6	1.9	2.5	-1.2	1.6
Food consumed during 24 hour testing period	1.6	1.9	2.2	1.5	-1.3
Times rat made contact with spout	0.0	0.0	0.1	-0.2	0.2
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	-0.1
Mean num. licks in bursts	0.6	0.8	1.1	0.7	-1.1
Std. dev. time between licks in bursts	1.2	1.4	1.7	-1.3	1.0
Water consumed over 24 hours	0.0	0.0	0.0	-0.2	0.2
Indifference point 0 sec	5.9	9.5	10.0	-3.0	3.2
Indifference point AUC	0.3	0.4	0.4	-0.5	0.7
Indifference point function ln k	5.2	7.3	7.4	2.7	-2.7
Indifference point function log k	5.2	7.3	7.4	2.7	-2.7
Delay discounting total patch changes 0 sec	5.6	9.0	9.6	-2.9	3.1
Delay discounting total patch changes 12 sec	5.8	7.7	7.9	-2.7	2.8
Delay discounting total patch changes 18 sec	7.7	10.1	10.6	-3.1	3.3
Delay discounting total patch changes 24 sec	4.8	6.0	6.6	-2.3	2.6
Delay discounting total patch changes 6 sec	6.3	9.6	9.7	-3.1	3.1
Delay discounting time to switch 0 sec	2.3	3.5	4.2	-2.0	1.7
Delay discounting water rate 0 sec	3.1	5.0	5.4	2.3	-2.1
Delay discounting water rate 12 sec	2.8	4.2	4.9	2.2	-1.9
Delay discounting water rate 18 sec	0.5	0.6	0.6	0.8	-0.8
Delay discounting water rate 24 sec	4.7	6.4	6.6	2.6	-2.5
Delay discounting water rate 6 sec	5.4	7.9	8.3	2.9	-2.7
Locomotor activity	0.9	1.4	2.0	-1.4	0.9
Locomotor testing distance	3.1	5.1	5.6	-2.4	2.1
Locomotor testing rearing	2.2	3.5	3.7	-1.9	1.8
Light reinforcement 1	1.2	2.1	2.2	-1.5	1.4
Light reinforcement 2	0.1	0.1	0.2	-0.1	-0.5
Reaction time number correct	1.2	1.7	2.1	1.4	-1.1
Reaction time mean minus median	7.1	9.2	9.6	-3.0	3.1
Reaction time mean minus median AUC	5.2	6.7	7.2	-2.5	2.7
Reaction time num false alarms	1.6	2.2	2.3	-1.4	1.5
Reaction time num false alarms AUC	1.8	2.5	2.6	-1.6	1.6
Reaction time trials correct on left	1.2	1.7	2.1	1.4	-1.1
Reaction time trials on left	0.9	1.3	1.6	1.3	-1.0
Reaction time mean	0.8	1.0	1.0	-1.0	1.0
Reaction time mean AUC	0.4	0.6	0.6	-0.8	0.7
Median of all reaction times	0.0	0.0	0.0	-0.1	0.1
Reaction time omissions	8.4	11.4	12.2	-3.5	3.3
Reaction time false alarm rate	2.0	2.8	3.0	-1.7	1.6
Reaction time premature initiation rate	4.2	5.7	7.2	-2.7	2.0
Reaction time premature initiations	1.7	2.4	3.1	-1.8	1.3
Std. dev. reaction times	5.8	8.0	8.2	-2.8	2.9
Reaction time trials completed	0.9	1.3	1.6	1.3	-1.0
Reaction time trials AUC	1.5	2.2	2.7	1.6	-1.3
Social response proportion	0.1	0.1	0.1	-0.3	0.3
Social responses	6.4	8.3	8.6	-2.8	2.9
Social time	0.2	0.3	0.3	0.5	-0.5
Conditioned locomotion	0.1	0.1	0.3	-0.0	0.5
Cocaine response after cond. corrected	0.0	0.0	0.0	0.0	-0.2
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.5	0.3
Cocaine response before conditioning	2.3	2.8	2.9	-1.7	1.6
Saline control response	0.0	0.1	0.1	0.1	0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	0.8	0.9	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.6	-0.5
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. inactive responses	0.6	0.7	1.0	-1.0	0.7
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	0.1
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. lever latency	0.9	1.2	1.6	0.9	-1.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.0	0.3
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	0.9	-0.5
Pavlov. Cond. index score	0.4	0.5	0.9	-0.4	0.9
Pavlov. Cond. latency score	0.4	0.5	0.8	-0.4	0.9
Pavlov. Cond. lever contacts	0.9	1.2	1.5	-0.9	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.4	-0.2
Pavlov. Cond. intertrial magazine entries	2.5	3.2	3.7	-1.9	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.1	0.6
Pavlov. Cond. response bias	0.5	0.6	0.9	-0.6	1.0
Conditioned reinforcement - actives	1.3	1.2	1.3	-1.1	1.1
Conditioned reinforcement - inactives	2.2	2.5	2.5	-1.6	1.6
Conditioned locomotion	0.2	0.3	0.3	-0.5	0.6
Intermittent access intake day 1-15 change	0.4	0.4	0.4	-0.6	0.6
Intermittent access intake escalation	0.1	0.1	0.1	-0.3	0.3
Intermittent access intake escalation 2	0.3	0.3	0.3	-0.6	0.5
Intermitt. access day 1 inactive lever presses	0.5	0.6	0.6	-0.8	0.8
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.2	-0.4	0.4
Intermitt. access escalation Index	0.7	0.6	0.6	-0.8	0.8
Intermittent access day 1 total infusions	1.3	1.5	1.5	-1.2	1.2
Intermittent access day 15 total infusions	2.1	2.4	2.5	-1.6	1.5
Intermittent access terminal intake (last 3 days)	2.2	2.4	2.4	-1.6	1.5
Intermittent access total infusions	2.0	2.2	2.3	-1.5	1.5
Intermittent access day 1 locomotion	1.4	1.4	1.5	-1.2	1.2
Intermittent access day 15 total locomotion	1.5	1.6	1.7	-1.2	1.3
Intermittent access total locomotion	4.2	4.8	4.9	-2.2	2.2
Intermittent access standard deviation	0.0	0.0	0.0	-0.2	0.1
Cocaine induced anxiety	1.2	1.4	1.7	1.0	-1.3
Post-drug Anxiety	5.9	6.5	6.9	2.5	-2.6
Baseline Anxiety	0.9	0.9	0.9	1.0	-0.9
Lifetime Intake	2.7	3.1	3.2	-1.8	1.7
Incentive Sensitization - Responses	0.2	0.2	0.2	0.5	-0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	0.4	-0.3
Progressive ratio test 1 active lever presses	8.4	8.7	8.9	-3.0	2.9
Progressive ratio test 1 breakpoint	7.3	7.5	7.7	-2.8	2.7
Progressive ratio test 1 inactive lever presses	2.6	2.8	2.9	-1.7	1.6
Progressive ratio test 2 active lever presses	2.3	2.4	2.5	-1.6	1.5
Progressive ratio test 2 breakpoint	2.6	2.9	3.0	-1.7	1.7
Progressive ratio test 2 inactive lever presses	1.4	1.7	1.7	-1.3	1.3
Total sessions with >9 infusions	1.7	1.9	1.9	-1.4	1.4
Short access day 1 total inactive lever presses	1.4	1.6	1.6	-1.3	1.3
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.1	-0.0
Short access day 1 total infusions	0.5	0.6	0.6	-0.8	0.7
Short access day 10 total infusions	2.7	2.9	3.0	-1.7	1.7
Short access total infusions	1.8	2.0	2.0	-1.4	1.4
Short access day 1 locomotion	0.3	0.3	0.3	-0.5	0.6
Short access day 10 total locomotion	0.1	0.2	0.2	-0.4	0.4
Short access total locomotion	0.6	0.6	0.6	-0.8	0.8
Compulsive drug intake	1.7	1.7	1.9	1.4	-1.2
One hour access (0.3 mA shock)	0.0	0.0	0.0	-0.0	0.0
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.1
Number of responses in last shaping day	0.2	0.3	0.3	0.5	-0.5
Context. condit. distance diff. score	0.2	0.2	0.3	0.5	-0.4
Locomotion velocity, session 1	3.6	3.8	3.9	-2.0	1.9
Locomotion distance, session 1	3.0	3.8	3.8	-2.0	2.0
Locomotion velocity, session 2	0.3	0.4	0.4	-0.6	0.6
Locomotion distance, session 2	3.0	4.3	4.3	-2.1	2.1
Locomotion velocity, session 3	5.0	5.9	5.9	-2.4	2.4
Locomotion distance, session 3	3.4	3.7	4.1	-2.0	1.8
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	0.3	-0.2
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.0	0.1
Locomotion velocity, session 7	2.5	2.7	2.8	-1.6	1.7
Locomotion distance, session 7	3.9	4.9	5.1	-2.3	2.2
Stereotopy head waving bouts, day 7	0.6	0.6	0.6	0.8	-0.8
Stereotopy head waving duration, day 7	1.1	1.3	1.4	1.2	-1.1
Locomotion velocity, session 8	0.5	0.6	0.8	-0.6	0.9
Locomotion distance, session 8	1.3	1.9	2.1	-1.3	1.5
Degree of sensitization distance	0.0	0.0	0.0	0.2	-0.1
Degree of sensitization stereotypy	0.6	0.6	0.7	0.8	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	0.4	-0.4
Condit. Reinf. active responses	0.8	1.0	1.0	-1.0	1.0
Condit. Reinf. inactive responses	3.2	3.7	3.8	-1.9	1.9
Incentive salience index mean	0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. lever presses	0.5	0.6	0.7	0.7	-0.8
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.0	0.0
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.2	-0.2
Total zone transitions, hab. session 1	0.1	0.1	0.1	-0.3	0.4
Total locomotion distance, hab. session 1	0.2	0.4	0.4	-0.5	0.7
Locomotion velocity, hab. session 1	0.1	0.2	0.3	-0.4	0.5
Time in familiar zone, hab. session 2	1.4	1.4	1.5	1.2	-1.2
Time in novel zone, hab. session 2	1.6	1.6	1.8	-1.2	1.3
Total zone transitions, hab. session 2	0.3	0.3	0.4	-0.6	0.6
Total locomotion distance, hab. session 2	0.4	0.5	0.6	-0.6	0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.3	-0.5	0.6
Novel to familiar place preference ratio	1.4	1.4	1.7	1.3	-1.1
Novelty place preference	0.8	0.8	1.0	1.0	-0.7
Time in novel zone, NPP test	0.5	0.5	0.7	0.9	-0.5
Total zone transitions, NPP test	2.5	3.6	3.6	-1.9	1.9
Total locomotion distance, NPP test	3.5	4.8	5.1	-2.1	2.3
Locomotion velocity, NPP test	2.3	3.2	3.4	-1.7	1.9
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.2	0.4
Pavlov. Cond. magazine entry latency	0.8	1.1	1.2	0.9	-1.1
Pavlov. Cond. change in total contacts	1.1	1.1	1.4	0.9	-1.2
Pavlov. Cond. index score	0.5	0.7	0.8	0.7	-0.9
Pavlov. Cond. latency score	0.3	0.4	0.5	0.6	-0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.0	-0.2
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.5	0.7
Pavlov. Cond. intertrial magazine entries	4.3	5.1	5.8	-2.1	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.2	1.0	-1.1
Pavlov. Cond. response bias	0.2	0.2	0.4	0.4	-0.6
Bone: apparent density	8.4	13.9	14.2	3.8	-3.7
Bone surface	10.8	19.0	19.5	4.4	-4.3
Bone volume	9.6	16.3	16.5	4.1	-4.0
Bone: connectivity density	4.5	7.1	7.6	2.7	-2.6
Bone: cortical apparent density	0.2	0.2	0.3	-0.6	0.3
Bone: cortical area	6.6	10.0	10.4	3.2	-3.1
Bone: cortical porosity	0.0	0.0	0.0	0.0	0.0
Bone: cortical porosity	0.1	0.1	0.1	-0.2	0.3
Bone: cortical thickness	1.7	2.9	3.1	1.8	-1.6
Bone: cortical thickness	0.2	0.2	0.3	-0.4	0.5
Bone: cortical tissue density	0.2	0.3	0.5	-0.7	0.4
Bone: elastic displacement	6.5	7.3	7.4	-2.7	2.7
Bone: elastic work	0.0	0.1	0.1	0.0	-0.3
Bone: endosteal estimation	8.0	17.2	17.8	4.2	-4.1
Bone: endosteal perimeter	6.8	14.0	15.3	3.9	-3.6
Bone: final force	11.5	18.9	19.0	4.3	-4.4
Bone: final moment	12.9	21.3	21.3	4.6	-4.6
Bone: marrow area	7.5	16.1	16.8	4.1	-3.9
Bone: maximum diameter	1.8	3.3	3.6	1.9	-1.7
Bone: maximum force	15.8	27.4	27.8	5.2	-5.3
Bone: maximum moment	17.4	30.3	30.5	5.5	-5.5
Bone: minimum diameter	9.1	16.8	17.3	4.2	-4.0
Bone: periosteal estimation	10.4	21.3	22.0	4.7	-4.5
Bone: periosteal perimeter	9.4	15.7	17.0	4.1	-3.8
Bone: post-yield work	9.3	12.7	12.9	3.6	-3.5
Bone: stiffness	20.0	31.5	31.8	5.6	-5.6
Bone: tissue strength	2.5	2.4	2.8	1.4	-1.7
Bone: trabecular number	4.6	7.1	7.6	2.7	-2.6
Bone: trabecular spacing	1.8	2.3	2.6	-1.4	1.6
Bone: trabecular thickness	0.5	0.6	0.9	0.6	-1.0
Bone: trabecular tissue density	0.5	0.8	0.9	0.8	-0.9
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	-0.4
Distance traveled before self-admin	2.0	2.2	2.6	-1.6	1.3
Distance traveled after self-admin	0.4	0.5	0.6	-0.8	0.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.4	-0.2
Delta time in open arm before/after self-admin	4.2	4.0	4.1	-2.0	2.0
Diff in mean of infusions in LGA sessions	1.7	1.9	2.0	1.3	-1.4
Extinction: sum of active levers before priming	0.8	0.8	0.8	0.9	-0.9
Active lever presses in extinction session 6	0.1	0.1	0.2	0.3	-0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.4	-0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.3	-0.1
Time in closed arm before self-admin	1.2	1.4	1.4	1.1	-1.2
Time in closed arm after self-admin	0.5	0.5	0.5	0.7	-0.7
Time in open arm before self-admin	0.3	0.3	0.4	0.4	-0.6
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	0.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.5	-0.6	0.7
Time to tail flick, vehicle, before self-admin	0.8	0.8	0.8	-0.9	0.9
Time to tail flick, vehicle, after self-admin	0.6	0.7	0.8	0.8	-0.9
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.4	0.1
Time to tail flick, test, after self-admin	0.9	0.9	1.0	0.9	-1.0
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	0.8	0.9	-0.9
Delta time to tail flick, test, before/after SA	0.6	0.5	0.7	0.8	-0.6
Ambulatory time before self-admin	4.2	4.4	4.7	-2.2	2.0
Ambulatory time after self-admin	2.1	2.3	2.4	-1.5	1.6
Total heroin consumption	1.4	1.7	1.8	1.3	-1.3
Area under the delay curve	1.2	1.3	1.4	1.1	-1.2
Delay disc. indifference point, 0s delay	2.0	2.2	2.3	1.5	-1.4
Delay disc. indifference point, 16s delay	1.0	1.0	1.1	1.0	-1.0
Delay disc. indifference point, 2s delay	2.2	2.4	2.5	1.5	-1.6
Delay disc. indifference point, 24s delay	0.8	0.8	0.8	0.9	-0.9
Delay disc. indifference point, 4s delay	1.1	1.1	1.1	1.0	-1.1
Delay disc. indifference point, 8s delay	1.9	1.9	2.0	1.3	-1.4
Delay discount exponential model param	1.2	1.3	1.4	-1.1	1.2
Delay discount hyperbolic model param	1.3	1.4	1.5	-1.1	1.2
Fecal boli incidents, locomotor time 1	1.5	1.6	1.7	-1.2	1.3
Change in fecal boli incidents, locomotor task	0.6	0.6	0.6	0.7	-0.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	0.1
Total resting periods, locomotor time 1	0.4	0.4	0.5	-0.6	0.7
Rest time, locomotor task time 1	0.8	0.8	0.9	-0.9	1.0
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.0	0.0
Vertical activity count, locomotor time 1	1.2	1.3	1.4	1.1	-1.2
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.5	-0.7	0.5
Bouts of movement, locomotor time 2	3.3	3.6	3.7	1.9	-1.9
Total resting periods, locomotor time 2	3.7	4.0	4.2	2.1	-1.9
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.3	0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.3	0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.3	-0.4
Weight adjusted by age	0.7	0.8	1.0	0.7	-1.0
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	0.7	0.9	-0.6
Locomotion in novel chamber	2.2	2.7	2.9	1.7	-1.6
Locomotion in novel chamber post-restriction	0.4	0.4	0.4	0.6	-0.7
Progressive ratio	0.8	0.9	0.9	-0.9	0.9
Food seeking constrained by brief footshock	1.4	1.7	1.9	-1.4	1.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.3	-0.4
Run reversals in cocaine runway, females	0.3	0.3	0.3	0.6	-0.6
Run reversals in cocaine runway, males	1.3	1.2	1.5	-1.0	1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.0	-0.0
Latency to leave start box in cocaine runway, F	1.5	1.7	1.9	-1.4	1.2
Latency to leave start box in cocaine runway, M	2.2	2.2	2.5	1.6	-1.4
Cd content in liver	0.7	0.7	0.8	-0.8	0.9
Co content in liver	0.5	0.6	0.8	-0.9	0.6
Cu content in liver	0.2	0.2	0.3	0.6	-0.2
Fe content in liver	0.9	1.0	1.1	-1.1	1.0
K content in liver	0.1	0.1	0.1	-0.2	0.3
Mg content in liver	0.3	0.3	0.3	-0.5	0.6
Mn content in liver	0.1	0.2	0.2	0.4	-0.4
Na content in liver	0.3	0.3	0.3	-0.5	0.5
Rb content in liver	2.2	2.8	3.2	-1.5	1.8
Se content in liver	2.3	2.8	3.2	-1.6	1.8
Sr content in liver	0.0	0.0	0.0	0.1	-0.0
Zn content in liver	3.1	3.4	3.6	-1.8	1.9