Hub : Genes

Nol11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000052934 0.09 0.05 7.0e-05 0.02 0.04 0.04 0.03 8.5e-03 6.5e-05 7.8e-05 1.5e-03
2 Brain mRNA stability ENSRNOG00000052934 0.08 0.05 9.6e-05 0.01 0.03 0.03 0.03 6.7e-02 6.8e-04 3.7e-04 1.4e-03
3 PL gene expression ENSRNOG00000052934 0.05 0.03 1.8e-03 -0 0.02 0.01 0.02 4.0e-01 9.5e-03 8.6e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail3.310.713.9-2.3-3.6-3.7
BMI without tail3.98.213.0-2.9-1.8-3.6
Body weight1.04.46.1-2.3-1.2-2.5
Epididymis fat weight0.10.30.60.5-0.8-0.4
Glucose0.00.00.00.2-0.1-0.2
Heart weight1.01.42.3-1.5-0.7-1.2
Left kidney weight3.08.711.5-3.3-2.0-3.4
Right kidney weight1.85.06.5-2.3-1.7-2.6
Tail length0.30.92.5-0.61.60.0
Length with tail0.31.02.3-0.31.50.8
Length without tail0.51.12.11.00.51.5
Liver weight, left0.20.40.70.10.90.7
Liver weight, right1.01.72.6-1.1-1.6-1.1
Parametrial fat weight0.40.81.41.0-0.31.2
Retroperitoneal fat weight0.10.20.40.60.50.1
Intraocular pressure1.52.12.9-1.6-0.9-1.7
Extensor digitorum longus weight0.62.54.02.0-1.90.1
Soleus weight0.72.13.5-1.9-0.7-1.5
Tibialis anterior weight0.31.23.00.4-1.7-0.6
Tibia length1.33.86.9-2.6-0.6-2.0
Number of licking bursts0.00.00.00.10.20.2
Food consumed during 24 hour testing period0.20.20.5-0.2-0.3-0.7
Times rat made contact with spout0.10.10.10.40.30.4
Mean time between licks in bursts0.10.10.2-0.0-0.4-0.2
Mean num. licks in bursts0.10.10.2-0.2-0.4-0.3
Std. dev. time between licks in bursts0.10.20.40.3-0.6-0.2
Water consumed over 24 hours0.70.81.2-0.5-1.1-1.0
Indifference point 0 sec1.72.75.8-2.40.2-1.5
Indifference point AUC0.10.10.2-0.40.3-0.1
Indifference point function ln k1.21.71.9-1.3-1.4-1.2
Indifference point function log k1.21.71.9-1.3-1.4-1.2
Delay discounting total patch changes 0 sec1.42.24.9-2.20.4-1.3
Delay discounting total patch changes 12 sec0.70.92.1-0.81.40.2
Delay discounting total patch changes 18 sec0.60.81.2-1.10.9-0.6
Delay discounting total patch changes 24 sec1.82.34.7-2.20.2-1.5
Delay discounting total patch changes 6 sec0.81.22.8-1.70.2-0.8
Delay discounting time to switch 0 sec0.91.32.01.41.10.9
Delay discounting water rate 0 sec0.81.22.1-1.5-0.8-1.0
Delay discounting water rate 12 sec2.13.14.0-1.5-2.0-1.7
Delay discounting water rate 18 sec2.22.93.8-1.6-1.9-1.5
Delay discounting water rate 24 sec0.20.30.7-0.8-0.2-0.5
Delay discounting water rate 6 sec1.52.12.7-1.3-1.7-1.4
Locomotor activity2.84.57.1-2.7-0.4-2.5
Locomotor testing distance2.64.37.3-2.7-0.0-2.4
Locomotor testing rearing0.50.82.1-0.41.5-0.3
Light reinforcement 13.66.58.1-2.3-2.5-2.8
Light reinforcement 22.12.83.1-1.7-1.8-1.6
Reaction time number correct1.01.41.6-1.3-1.2-1.0
Reaction time mean minus median0.60.81.81.30.10.8
Reaction time mean minus median AUC0.30.31.0-0.0-1.0-0.2
Reaction time num false alarms1.31.83.1-1.81.3-0.7
Reaction time num false alarms AUC1.01.32.0-1.41.3-0.4
Reaction time trials correct on left1.01.41.6-1.3-1.2-1.0
Reaction time trials on left0.91.31.6-1.2-1.2-1.0
Reaction time mean0.40.50.60.70.60.8
Reaction time mean AUC0.50.60.80.90.60.8
Median of all reaction times0.20.30.60.30.80.5
Reaction time omissions0.20.20.40.6-0.00.6
Reaction time false alarm rate0.91.33.8-0.41.90.3
Reaction time premature initiation rate1.31.71.9-1.4-1.4-1.2
Reaction time premature initiations2.13.03.4-1.8-1.8-1.6
Std. dev. reaction times1.41.92.91.70.51.6
Reaction time trials completed0.91.31.6-1.2-1.2-1.0
Reaction time trials AUC0.81.11.3-1.1-1.1-0.9
Social response proportion0.20.20.4-0.3-0.6-0.4
Social responses0.70.91.2-1.0-0.6-1.1
Social time0.60.81.20.90.71.1
Conditioned locomotion0.10.10.20.20.40.1
Cocaine response after cond. corrected0.20.20.40.6-0.10.6
Cocaine response after cond. not corrected0.60.70.90.90.61.0
Cocaine response before conditioning0.20.30.4-0.60.6-0.2
Saline control response0.40.51.1-0.60.4-1.0
Condit. Reinf. active minus inactive responses1.92.34.4-2.11.5-0.5
Condit. Reinf. active-inactive response ratio1.01.02.6-0.41.60.5
Condit. Reinf. active responses1.72.44.8-2.21.4-0.6
Condit. Reinf. inactive responses2.02.55.2-2.3-0.3-1.5
Condit. Reinf. lever presses1.41.93.4-1.80.7-1.3
Condit. Reinf. lever reinforcers received1.31.93.8-2.01.2-0.6
Pavlov. Cond. lever latency0.60.91.41.2-0.90.6
Pavlov. Cond. magazine entry latency0.20.20.50.40.70.2
Pavlov. Cond. change in total contacts0.40.61.4-0.51.20.2
Pavlov. Cond. index score0.40.51.3-0.51.1-0.2
Pavlov. Cond. latency score0.50.61.4-0.51.2-0.1
Pavlov. Cond. lever contacts0.60.91.3-1.20.8-0.9
Pavlov. Cond. magazine entry number0.00.10.2-0.1-0.40.0
Pavlov. Cond. intertrial magazine entries0.30.40.80.40.60.9
Pavlov. Cond. lever-magazine prob. diff.0.40.51.3-0.51.1-0.1
Pavlov. Cond. response bias0.40.50.7-0.80.9-0.5
Conditioned reinforcement - actives0.20.20.3-0.50.3-0.5
Conditioned reinforcement - inactives0.30.40.8-0.90.3-0.4
Conditioned locomotion0.30.40.6-0.80.4-0.5
Intermittent access intake day 1-15 change2.82.83.92.00.72.0
Intermittent access intake escalation1.91.92.71.60.51.6
Intermittent access intake escalation 23.23.14.52.00.82.1
Intermitt. access day 1 inactive lever presses0.91.02.2-1.50.6-0.7
Intermitt. access day 15 inactive lever presses0.00.00.00.10.20.1
Intermitt. access escalation Index0.40.40.70.8-0.20.6
Intermittent access day 1 total infusions2.52.94.2-2.0-1.0-1.9
Intermittent access day 15 total infusions0.10.20.4-0.2-0.6-0.2
Intermittent access terminal intake (last 3 days)0.00.00.1-0.00.10.3
Intermittent access total infusions0.80.91.8-1.4-0.1-0.9
Intermittent access day 1 locomotion1.71.83.3-1.8-0.1-1.4
Intermittent access day 15 total locomotion0.30.40.8-0.90.5-0.3
Intermittent access total locomotion1.71.93.9-2.00.1-1.3
Intermittent access standard deviation0.10.10.1-0.4-0.2-0.2
Cocaine induced anxiety0.30.40.5-0.6-0.7-0.5
Post-drug Anxiety0.00.00.1-0.1-0.3-0.1
Baseline Anxiety0.10.10.10.3-0.2-0.4
Lifetime Intake1.92.14.0-2.0-0.3-1.5
Incentive Sensitization - Responses0.60.61.1-0.01.00.8
Incentive Sensitization - Breakpoint0.70.71.20.11.11.0
Progressive ratio test 1 active lever presses2.02.13.7-1.90.4-1.6
Progressive ratio test 1 breakpoint2.62.74.5-2.10.3-1.8
Progressive ratio test 1 inactive lever presses3.23.46.6-2.6-0.2-1.9
Progressive ratio test 2 active lever presses0.80.81.9-1.40.6-0.5
Progressive ratio test 2 breakpoint0.50.61.1-1.00.8-0.1
Progressive ratio test 2 inactive lever presses1.41.63.8-1.9-0.2-1.0
Total sessions with >9 infusions6.16.79.4-3.1-1.1-3.1
Short access day 1 total inactive lever presses1.21.32.7-1.6-0.1-1.2
Short access day 10 total inactive lever presses0.00.00.0-0.1-0.20.1
Short access day 1 total infusions7.78.212.4-3.5-1.2-3.3
Short access day 10 total infusions1.92.13.5-1.9-0.5-1.6
Short access total infusions3.94.47.4-2.7-0.5-2.3
Short access day 1 locomotion6.46.89.9-3.2-1.3-2.9
Short access day 10 total locomotion0.91.02.0-1.40.5-0.8
Short access total locomotion4.54.67.0-2.7-0.8-2.5
Compulsive drug intake0.00.00.10.2-0.10.3
One hour access (0.3 mA shock)0.10.10.3-0.30.6-0.0
One hour access (shock baseline)0.10.10.2-0.50.2-0.3
Number of responses in last shaping day1.41.52.4-1.5-0.5-1.3
Context. condit. distance diff. score0.00.00.1-0.30.1-0.1
Locomotion velocity, session 10.10.10.2-0.5-0.0-0.3
Locomotion distance, session 11.11.42.4-1.5-0.5-1.3
Locomotion velocity, session 20.60.72.00.11.40.2
Locomotion distance, session 20.50.81.2-1.10.2-1.0
Locomotion velocity, session 31.92.22.7-1.5-1.2-1.7
Locomotion distance, session 30.20.20.6-0.80.0-0.3
Stereotopy head waving bouts, day 30.60.71.6-0.3-1.3-0.6
Stereotopy head waving duration, day 30.70.91.4-0.8-1.2-0.8
Locomotion velocity, session 70.20.20.40.7-0.40.2
Locomotion distance, session 70.10.10.2-0.20.4-0.0
Stereotopy head waving bouts, day 70.30.40.6-0.5-0.4-0.8
Stereotopy head waving duration, day 70.00.00.10.1-0.1-0.2
Locomotion velocity, session 80.70.91.00.81.01.0
Locomotion distance, session 80.20.30.4-0.60.5-0.4
Degree of sensitization distance0.40.40.60.50.80.5
Degree of sensitization stereotypy0.40.40.9-0.6-0.0-0.9
Condit. Reinf. active minus inactive responses1.11.21.8-1.31.3-0.2
Condit. Reinf. active-inactive response ratio0.60.61.4-0.41.20.5
Condit. Reinf. active responses1.11.32.0-1.41.4-0.3
Condit. Reinf. inactive responses0.40.50.9-1.00.4-0.5
Incentive salience index mean0.70.91.7-0.91.3-0.2
Condit. Reinf. lever presses0.10.20.3-0.10.6-0.4
Time in familiar zone, hab. session 11.11.11.61.00.81.3
Time in novel zone, hab. session 11.21.21.6-0.7-1.2-1.3
Total zone transitions, hab. session 11.11.52.5-1.4-0.5-1.6
Total locomotion distance, hab. session 11.92.73.9-1.9-0.7-2.0
Locomotion velocity, hab. session 11.21.72.6-1.6-0.2-1.6
Time in familiar zone, hab. session 21.21.22.10.61.41.2
Time in novel zone, hab. session 20.80.81.5-0.4-1.2-0.9
Total zone transitions, hab. session 20.40.51.0-0.5-0.4-1.0
Total locomotion distance, hab. session 20.81.11.7-0.9-0.9-1.3
Locomotion velocity, hab. session 20.81.11.5-0.8-1.0-1.2
Novel to familiar place preference ratio0.20.20.4-0.6-0.1-0.3
Novelty place preference0.10.10.3-0.5-0.2-0.3
Time in novel zone, NPP test0.20.20.4-0.6-0.2-0.3
Total zone transitions, NPP test2.73.95.4-2.2-1.3-2.3
Total locomotion distance, NPP test0.81.11.6-1.2-0.6-1.2
Locomotion velocity, NPP test1.82.63.5-1.7-1.2-1.9
Pavlov. Cond. lever latency0.70.91.41.2-0.41.1
Pavlov. Cond. magazine entry latency0.60.81.3-1.11.0-0.5
Pavlov. Cond. change in total contacts0.60.71.1-1.00.5-0.8
Pavlov. Cond. index score0.81.01.8-1.30.7-0.8
Pavlov. Cond. latency score0.81.01.8-1.30.6-1.0
Pavlov. Cond. lever contacts0.20.30.4-0.40.5-0.6
Pavlov. Cond. magazine entry number0.70.81.71.3-0.70.5
Pavlov. Cond. intertrial magazine entries1.92.34.6-2.1-0.4-1.5
Pavlov. Cond. lever-magazine prob. diff.0.81.11.9-1.40.6-0.9
Pavlov. Cond. response bias0.80.91.7-1.30.7-0.8
Bone: apparent density0.10.10.1-0.3-0.30.2
Bone surface1.11.93.60.01.91.4
Bone volume0.30.50.7-0.50.80.7
Bone: connectivity density0.20.30.4-0.00.60.6
Bone: cortical apparent density5.06.512.7-1.3-3.6-2.3
Bone: cortical area3.24.96.8-2.6-1.6-2.2
Bone: cortical porosity1.71.94.70.22.20.9
Bone: cortical porosity0.70.71.1-1.01.0-0.3
Bone: cortical thickness12.821.127.7-3.4-5.3-4.9
Bone: cortical thickness5.76.79.0-1.9-3.0-2.8
Bone: cortical tissue density4.55.912.1-1.1-3.5-2.1
Bone: elastic displacement2.02.23.6-1.0-1.9-1.4
Bone: elastic work1.72.24.0-0.9-2.0-1.3
Bone: endosteal estimation6.514.129.80.95.53.4
Bone: endosteal perimeter4.69.519.90.24.52.9
Bone: final force0.91.53.0-1.7-0.8-1.0
Bone: final moment0.81.42.7-1.6-0.7-0.9
Bone: marrow area6.714.430.01.05.53.5
Bone: maximum diameter0.71.22.1-1.51.20.2
Bone: maximum force1.83.26.2-2.5-0.8-1.6
Bone: maximum moment1.62.75.4-2.3-0.8-1.5
Bone: minimum diameter1.01.83.8-0.92.00.9
Bone: periosteal estimation1.12.35.1-1.12.20.7
Bone: periosteal perimeter0.50.91.9-1.40.90.2
Bone: post-yield work0.71.02.20.11.50.9
Bone: stiffness0.61.02.3-1.50.4-0.7
Bone: tissue strength0.90.91.3-1.1-0.5-1.0
Bone: trabecular number0.20.20.6-0.80.30.1
Bone: trabecular spacing0.20.30.70.80.30.3
Bone: trabecular thickness0.20.20.3-0.5-0.6-0.1
Bone: trabecular tissue density2.53.53.9-1.8-2.0-1.8
Breakpoint value in progressive ratio session0.20.20.60.00.80.0
Distance traveled before self-admin0.10.10.30.20.30.6
Distance traveled after self-admin0.20.20.40.00.60.4
Delta time in closed arm before/after self-admin0.80.81.00.61.01.0
Delta time in open arm before/after self-admin0.50.51.0-0.4-1.0-0.6
Diff in mean of infusions in LGA sessions0.60.71.1-0.2-1.0-1.0
Extinction: sum of active levers before priming0.10.10.2-0.4-0.4-0.4
Active lever presses in extinction session 60.00.00.1-0.10.3-0.0
Delta distance traveled before/after self-admin0.60.71.3-0.7-0.5-1.1
Delta ambulatory time before/after self-admin0.20.20.4-0.4-0.3-0.6
Time in closed arm before self-admin1.01.21.9-1.0-0.8-1.4
Time in closed arm after self-admin0.60.60.70.80.80.7
Time in open arm before self-admin0.60.61.21.10.20.8
Time in open arm after self-admin0.00.00.10.1-0.30.2
Sum of active levers in priming session hrs 5-60.50.51.0-0.4-1.0-0.6
Time to tail flick, vehicle, before self-admin1.51.53.11.00.81.8
Time to tail flick, vehicle, after self-admin0.20.20.4-0.20.40.6
Time to tail flick, test, before self-admin2.32.33.51.90.41.8
Time to tail flick, test, after self-admin0.50.51.0-0.6-1.0-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.30.10.60.3
Delta time to tail flick, test, before/after SA0.80.71.4-1.2-0.4-0.6
Ambulatory time before self-admin0.10.10.20.10.30.4
Ambulatory time after self-admin0.10.10.2-0.50.2-0.2
Total heroin consumption0.20.30.6-0.80.4-0.3
Area under the delay curve0.70.71.1-1.1-0.8-0.6
Delay disc. indifference point, 0s delay0.10.10.2-0.0-0.5-0.0
Delay disc. indifference point, 16s delay1.61.61.8-1.3-1.4-1.2
Delay disc. indifference point, 2s delay0.20.20.5-0.70.10.1
Delay disc. indifference point, 24s delay2.42.43.3-1.8-1.1-1.6
Delay disc. indifference point, 4s delay0.00.00.1-0.2-0.3-0.0
Delay disc. indifference point, 8s delay0.90.91.2-1.0-1.1-0.8
Delay discount exponential model param0.40.40.70.90.50.4
Delay discount hyperbolic model param0.40.40.90.90.50.4
Fecal boli incidents, locomotor time 10.20.20.50.50.20.7
Change in fecal boli incidents, locomotor task0.70.71.1-0.6-1.1-0.7
Time >=10cm from walls, locomotor time 10.00.10.10.20.20.2
Bouts of movement, locomotor time 10.30.30.70.2-0.9-0.4
Total resting periods, locomotor time 10.30.30.70.5-0.8-0.1
Rest time, locomotor task time 10.50.61.11.10.10.8
Distance moved, locomotor task time 10.10.10.1-0.2-0.2-0.3
Vertical activity count, locomotor time 10.00.00.1-0.2-0.1-0.2
Time >=10cm from walls, locomotor time 21.61.73.01.70.91.1
Bouts of movement, locomotor time 20.60.71.70.3-1.3-0.6
Total resting periods, locomotor time 20.70.71.70.1-1.3-0.7
Rest time, locomotor task time 20.30.30.60.8-0.40.4
Distance moved, locomotor task time 20.30.30.70.90.30.2
Vertical activity count, locomotor time 20.00.00.00.20.0-0.0
Weight adjusted by age0.10.10.1-0.30.0-0.4
Seeking ratio, delayed vs. immediate footshock0.30.40.6-0.6-0.3-0.8
Locomotion in novel chamber0.20.30.6-0.20.70.5
Locomotion in novel chamber post-restriction0.80.91.40.11.21.1
Progressive ratio1.21.41.80.91.31.4
Food seeking constrained by brief footshock4.35.27.71.82.82.2
Seeking ratio, punishment vs. effort0.10.10.20.10.5-0.1
Run reversals in cocaine runway, females1.01.02.31.5-0.70.2
Run reversals in cocaine runway, males0.10.10.1-0.4-0.3-0.0
Latency to leave start box in cocaine runway0.00.00.10.2-0.0-0.3
Latency to leave start box in cocaine runway, F0.60.61.0-0.9-0.1-1.0
Latency to leave start box in cocaine runway, M1.51.42.91.70.21.1
Cd content in liver0.91.01.61.30.11.2
Co content in liver1.21.41.71.30.91.3
Cu content in liver0.00.10.10.30.00.3
Fe content in liver0.40.50.9-0.9-0.3-0.7
K content in liver0.40.40.70.20.70.8
Mg content in liver1.01.01.71.20.31.3
Mn content in liver0.30.40.9-1.0-0.1-0.3
Na content in liver0.30.30.7-0.80.5-0.2
Rb content in liver0.00.10.10.0-0.30.2
Se content in liver0.30.40.6-0.8-0.5-0.6
Sr content in liver0.20.20.2-0.5-0.3-0.5
Zn content in liver0.60.61.1-1.0-0.9-0.4