Hub : Genes

Psmb3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	ENSRNOG00000052730	0.15	0.09	3.3e-03	0.02	0	0.02	0.01	3.4e-03	1.1e-01	3.7e-03	1.4e-02
2	NAcc	isoform ratio	ENSRNOT00000112080	0.09	0.07	2.1e-03	0.03	0.04	0.04	0.04	3.5e-03	8.4e-04	2.6e-04	5.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	2.6	8.4	16.3	4.0	-0.7
BMI without tail	0.0	0.1	0.1	0.2	0.3
Body weight	3.0	12.9	19.8	-2.4	4.4
Epididymis fat weight	0.3	0.8	0.8	-0.9	0.9
Glucose	0.1	0.2	0.3	-0.5	-0.4
Heart weight	0.5	0.6	1.3	0.1	1.1
Left kidney weight	3.8	10.9	11.6	-3.2	3.4
Right kidney weight	1.1	3.1	3.2	-1.7	1.8
Tail length	12.5	37.8	50.4	-7.1	5.0
Length with tail	14.1	51.9	58.1	-7.6	6.8
Length without tail	3.3	7.2	9.4	-2.2	3.1
Liver weight, left	0.8	1.4	1.7	-1.3	1.0
Liver weight, right	2.6	4.4	7.0	-2.6	1.3
Parametrial fat weight	0.2	0.3	0.6	0.2	-0.8
Retroperitoneal fat weight	0.4	1.4	1.6	-1.3	1.1
Intraocular pressure	1.8	2.6	2.7	-1.6	1.6
Extensor digitorum longus weight	3.0	12.0	21.3	-1.7	4.6
Soleus weight	0.2	0.7	0.9	0.7	-1.0
Tibialis anterior weight	1.1	3.8	5.4	-1.5	2.3
Tibia length	0.6	1.8	2.7	-1.0	1.6
Number of licking bursts	0.2	0.2	0.3	0.2	-0.6
Food consumed during 24 hour testing period	1.0	1.2	1.6	-0.9	1.3
Times rat made contact with spout	0.2	0.3	0.4	0.3	-0.7
Mean time between licks in bursts	0.2	0.3	0.6	0.1	0.8
Mean num. licks in bursts	0.0	0.0	0.0	-0.2	0.1
Std. dev. time between licks in bursts	0.4	0.5	1.0	1.0	-0.1
Water consumed over 24 hours	0.0	0.0	0.0	0.1	0.1
Indifference point 0 sec	0.6	0.9	1.4	0.6	-1.2
Indifference point AUC	0.0	0.0	0.1	0.1	0.3
Indifference point function ln k	0.1	0.1	0.1	-0.4	0.1
Indifference point function log k	0.1	0.1	0.1	-0.4	0.1
Delay discounting total patch changes 0 sec	0.3	0.5	0.8	0.4	-0.9
Delay discounting total patch changes 12 sec	1.5	2.0	3.2	0.8	-1.8
Delay discounting total patch changes 18 sec	1.4	1.8	2.4	1.5	-1.1
Delay discounting total patch changes 24 sec	1.1	1.3	1.7	1.0	-1.3
Delay discounting total patch changes 6 sec	0.9	1.4	1.6	1.1	-1.3
Delay discounting time to switch 0 sec	0.2	0.2	0.3	0.6	-0.4
Delay discounting water rate 0 sec	0.1	0.2	0.2	-0.5	0.4
Delay discounting water rate 12 sec	1.0	1.4	1.7	-1.3	1.1
Delay discounting water rate 18 sec	0.7	0.9	1.8	-1.4	0.1
Delay discounting water rate 24 sec	0.1	0.1	0.2	0.1	-0.4
Delay discounting water rate 6 sec	0.2	0.3	0.6	0.1	-0.8
Locomotor activity	1.5	2.3	2.5	1.6	-1.5
Locomotor testing distance	4.9	8.2	9.2	2.7	-3.0
Locomotor testing rearing	3.9	6.1	8.7	1.9	-2.9
Light reinforcement 1	2.5	4.6	5.2	2.0	-2.3
Light reinforcement 2	0.3	0.4	0.6	0.4	-0.8
Reaction time number correct	0.3	0.4	0.7	-0.4	0.8
Reaction time mean minus median	0.1	0.1	0.2	0.4	-0.1
Reaction time mean minus median AUC	0.6	0.8	0.8	0.9	-0.9
Reaction time num false alarms	0.4	0.6	1.0	0.3	-1.0
Reaction time num false alarms AUC	0.2	0.3	0.7	0.1	-0.8
Reaction time trials correct on left	0.3	0.4	0.7	-0.4	0.8
Reaction time trials on left	0.3	0.4	0.7	-0.4	0.8
Reaction time mean	0.7	1.0	1.6	1.3	-0.6
Reaction time mean AUC	0.6	0.8	1.3	1.1	-0.5
Median of all reaction times	1.3	1.8	2.5	1.6	-1.0
Reaction time omissions	0.3	0.4	0.6	0.4	-0.8
Reaction time false alarm rate	0.6	0.8	1.4	0.4	-1.2
Reaction time premature initiation rate	0.1	0.2	0.3	-0.6	-0.2
Reaction time premature initiations	0.3	0.4	0.7	-0.8	0.4
Std. dev. reaction times	0.1	0.2	0.2	0.5	-0.3
Reaction time trials completed	0.3	0.4	0.7	-0.4	0.8
Reaction time trials AUC	0.2	0.3	0.5	-0.3	0.7
Social response proportion	0.9	1.0	1.8	-1.3	0.5
Social responses	0.0	0.0	0.1	-0.1	-0.2
Social time	0.6	0.7	1.1	1.1	-0.6
Conditioned locomotion	0.1	0.1	0.2	0.3	-0.5
Cocaine response after cond. corrected	1.7	1.9	2.1	1.3	-1.5
Cocaine response after cond. not corrected	1.2	1.3	2.2	0.6	-1.5
Cocaine response before conditioning	0.6	0.8	1.5	-1.2	-0.3
Saline control response	0.2	0.2	0.4	0.2	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	0.5	-0.6
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.4	1.2	-0.8
Condit. Reinf. active responses	0.3	0.4	0.7	0.4	-0.8
Condit. Reinf. inactive responses	0.5	0.6	1.2	0.1	-1.1
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	0.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	0.3	-0.7
Pavlov. Cond. lever latency	0.5	0.6	0.7	-0.8	0.7
Pavlov. Cond. magazine entry latency	0.7	0.8	1.1	-1.1	0.7
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	0.6	-0.7
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	0.0
Pavlov. Cond. lever contacts	0.7	1.0	1.3	0.9	-1.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.6	-0.2
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.5	-0.7	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	-0.1
Pavlov. Cond. response bias	0.5	0.7	1.0	0.6	-1.0
Conditioned reinforcement - actives	2.2	2.2	2.5	1.4	-1.6
Conditioned reinforcement - inactives	0.5	0.6	1.0	0.4	-1.0
Conditioned locomotion	2.8	3.3	3.6	1.9	-1.8
Intermittent access intake day 1-15 change	0.7	0.7	0.7	0.8	-0.8
Intermittent access intake escalation	0.8	0.8	1.0	1.0	-0.8
Intermittent access intake escalation 2	0.3	0.3	0.5	0.7	-0.3
Intermitt. access day 1 inactive lever presses	0.3	0.4	0.6	0.3	-0.8
Intermitt. access day 15 inactive lever presses	3.2	3.5	3.6	1.8	-1.9
Intermitt. access escalation Index	0.1	0.1	0.2	0.2	0.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.0	-0.2
Intermittent access day 15 total infusions	0.3	0.3	0.4	0.5	-0.6
Intermittent access terminal intake (last 3 days)	0.5	0.6	0.7	0.7	-0.8
Intermittent access total infusions	0.0	0.0	0.0	-0.0	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.0	-0.4
Intermittent access day 15 total locomotion	0.8	0.9	1.0	0.9	-1.0
Intermittent access total locomotion	0.8	0.9	1.1	0.9	-1.1
Intermittent access standard deviation	0.6	0.6	0.6	0.8	-0.7
Cocaine induced anxiety	0.5	0.6	1.1	-0.3	1.0
Post-drug Anxiety	0.1	0.1	0.2	0.4	-0.2
Baseline Anxiety	3.0	3.1	3.7	1.6	-1.9
Lifetime Intake	0.0	0.0	0.0	0.0	-0.1
Incentive Sensitization - Responses	0.4	0.4	0.6	0.5	-0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.5	0.5	-0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.2	-0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	-0.4
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.6	0.4	-0.8
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	0.5	-0.8
Progressive ratio test 2 breakpoint	0.3	0.4	0.6	0.4	-0.8
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.5	-0.2
Total sessions with >9 infusions	0.4	0.5	0.7	0.5	-0.8
Short access day 1 total inactive lever presses	0.2	0.3	0.3	-0.4	-0.6
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.0	0.5
Short access day 1 total infusions	0.1	0.1	0.2	0.3	-0.4
Short access day 10 total infusions	0.1	0.2	0.2	0.4	-0.4
Short access total infusions	0.0	0.0	0.0	-0.1	0.0
Short access day 1 locomotion	0.8	0.8	1.4	0.5	-1.2
Short access day 10 total locomotion	1.3	1.4	2.1	0.8	-1.5
Short access total locomotion	0.5	0.5	0.7	0.5	-0.8
Compulsive drug intake	3.2	3.2	4.8	-2.2	1.2
One hour access (0.3 mA shock)	0.0	0.0	0.0	-0.1	-0.2
One hour access (shock baseline)	1.7	1.9	2.4	1.5	-1.2
Number of responses in last shaping day	0.3	0.3	0.6	0.8	-0.1
Context. condit. distance diff. score	0.0	0.0	0.1	0.1	0.3
Locomotion velocity, session 1	0.2	0.2	0.2	0.4	0.4
Locomotion distance, session 1	3.9	5.1	5.9	-2.0	2.4
Locomotion velocity, session 2	2.6	3.0	3.4	-1.8	1.6
Locomotion distance, session 2	3.5	5.0	5.5	-2.3	2.1
Locomotion velocity, session 3	0.2	0.3	0.3	-0.6	0.5
Locomotion distance, session 3	3.5	3.8	4.7	-2.2	1.7
Stereotopy head waving bouts, day 3	4.7	5.6	6.6	2.1	-2.6
Stereotopy head waving duration, day 3	1.8	2.2	2.2	1.5	-1.5
Locomotion velocity, session 7	1.7	1.9	2.2	-1.5	1.2
Locomotion distance, session 7	3.4	4.3	6.5	-2.5	1.4
Stereotopy head waving bouts, day 7	1.6	1.8	1.9	1.3	-1.4
Stereotopy head waving duration, day 7	1.0	1.3	1.5	1.2	-1.0
Locomotion velocity, session 8	1.7	2.0	3.7	-0.5	1.9
Locomotion distance, session 8	1.8	2.6	3.1	-1.5	1.8
Degree of sensitization distance	0.1	0.1	0.1	-0.2	0.3
Degree of sensitization stereotypy	1.4	1.5	1.9	1.0	-1.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.0	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	0.6	-0.9
Condit. Reinf. active responses	0.1	0.2	0.3	0.3	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	-0.5
Incentive salience index mean	0.2	0.2	0.5	-0.0	-0.7
Condit. Reinf. lever presses	0.2	0.2	0.4	0.0	-0.6
Time in familiar zone, hab. session 1	0.7	0.7	0.9	0.7	-0.9
Time in novel zone, hab. session 1	1.2	1.2	1.2	1.1	-1.1
Total zone transitions, hab. session 1	4.1	5.8	5.9	-2.4	2.4
Total locomotion distance, hab. session 1	0.7	0.9	1.4	-1.2	0.6
Locomotion velocity, hab. session 1	2.1	3.0	3.8	-1.9	1.5
Time in familiar zone, hab. session 2	1.4	1.5	1.6	1.3	-1.2
Time in novel zone, hab. session 2	0.3	0.3	0.5	-0.7	0.2
Total zone transitions, hab. session 2	0.7	0.9	1.0	-0.9	1.0
Total locomotion distance, hab. session 2	0.0	0.0	0.0	-0.1	0.0
Locomotion velocity, hab. session 2	0.2	0.2	0.2	-0.5	0.4
Novel to familiar place preference ratio	2.3	2.4	2.5	-1.6	1.5
Novelty place preference	2.1	2.2	2.6	-1.6	1.4
Time in novel zone, NPP test	1.2	1.2	1.6	-1.3	0.9
Total zone transitions, NPP test	1.4	2.0	2.5	-1.6	1.2
Total locomotion distance, NPP test	0.2	0.2	0.4	-0.6	0.3
Locomotion velocity, NPP test	1.0	1.4	1.7	-1.3	1.1
Pavlov. Cond. lever latency	0.5	0.7	1.3	-0.0	1.2
Pavlov. Cond. magazine entry latency	3.4	4.3	7.6	1.0	-2.8
Pavlov. Cond. change in total contacts	1.6	1.7	3.4	0.2	-1.8
Pavlov. Cond. index score	2.5	3.2	5.7	0.8	-2.4
Pavlov. Cond. latency score	1.7	2.2	4.1	0.5	-2.0
Pavlov. Cond. lever contacts	0.4	0.5	0.9	-0.0	-1.0
Pavlov. Cond. magazine entry number	4.9	6.1	10.0	-1.5	3.2
Pavlov. Cond. intertrial magazine entries	1.2	1.5	1.9	-1.0	1.4
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.5	6.4	0.8	-2.5
Pavlov. Cond. response bias	3.1	3.8	6.6	1.0	-2.6
Bone: apparent density	0.9	1.5	1.9	1.1	-1.4
Bone surface	0.1	0.2	0.4	-0.3	0.6
Bone volume	0.0	0.0	0.1	0.3	0.1
Bone: connectivity density	0.8	1.3	2.1	0.7	-1.4
Bone: cortical apparent density	0.8	1.0	1.8	-0.4	-1.3
Bone: cortical area	0.1	0.1	0.2	-0.5	0.2
Bone: cortical porosity	0.5	0.6	0.8	0.6	-0.9
Bone: cortical porosity	0.4	0.5	0.8	0.4	-0.9
Bone: cortical thickness	0.2	0.4	0.6	-0.8	-0.4
Bone: cortical thickness	1.0	1.1	1.7	-1.3	-0.7
Bone: cortical tissue density	0.8	1.0	1.8	-0.5	-1.4
Bone: elastic displacement	0.0	0.0	0.0	0.2	-0.1
Bone: elastic work	0.3	0.4	0.5	-0.7	0.5
Bone: endosteal estimation	0.9	1.9	3.1	-0.8	1.8
Bone: endosteal perimeter	0.5	1.1	2.1	-0.3	1.4
Bone: final force	0.2	0.3	0.6	0.0	-0.7
Bone: final moment	0.1	0.2	0.4	-0.1	-0.6
Bone: marrow area	0.8	1.8	3.0	-0.8	1.7
Bone: maximum diameter	0.0	0.0	0.0	0.1	0.1
Bone: maximum force	0.1	0.1	0.1	-0.4	0.2
Bone: maximum moment	0.1	0.2	0.3	-0.6	0.4
Bone: minimum diameter	0.7	1.3	1.5	-1.1	1.2
Bone: periosteal estimation	0.2	0.4	0.6	-0.5	0.8
Bone: periosteal perimeter	0.3	0.6	0.9	-0.5	0.9
Bone: post-yield work	0.4	0.5	0.8	-0.4	0.9
Bone: stiffness	0.1	0.1	0.2	-0.5	0.1
Bone: tissue strength	0.1	0.1	0.1	0.3	0.3
Bone: trabecular number	2.2	3.5	4.9	1.4	-2.2
Bone: trabecular spacing	0.1	0.1	0.2	0.4	0.1
Bone: trabecular thickness	0.0	0.0	0.1	-0.1	0.3
Bone: trabecular tissue density	0.0	0.0	0.0	-0.2	-0.0
Breakpoint value in progressive ratio session	2.8	3.1	3.8	-1.9	1.6
Distance traveled before self-admin	0.4	0.4	0.5	-0.7	0.5
Distance traveled after self-admin	0.2	0.2	0.3	0.4	0.5
Delta time in closed arm before/after self-admin	0.9	0.9	1.7	-0.3	1.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	-0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	-0.1
Extinction: sum of active levers before priming	1.1	1.1	1.4	-1.2	0.9
Active lever presses in extinction session 6	0.2	0.2	0.2	0.3	-0.5
Delta distance traveled before/after self-admin	0.7	0.8	1.6	1.3	-0.1
Delta ambulatory time before/after self-admin	0.7	0.8	1.4	1.2	-0.4
Time in closed arm before self-admin	1.1	1.2	1.6	0.9	-1.3
Time in closed arm after self-admin	0.1	0.1	0.2	0.2	0.4
Time in open arm before self-admin	0.7	0.7	1.5	-0.2	1.2
Time in open arm after self-admin	0.0	0.0	0.1	0.3	0.1
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.0	-1.0	0.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.4	-0.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	0.5	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.0	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	0.2
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.6	0.7	-0.8
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	-0.8	-0.2
Ambulatory time before self-admin	0.4	0.4	0.5	-0.6	0.7
Ambulatory time after self-admin	0.5	0.5	1.0	0.1	1.0
Total heroin consumption	0.0	0.1	0.1	-0.3	-0.2
Area under the delay curve	1.0	1.1	2.1	-1.5	0.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	-0.6	-0.3
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	-0.8	-0.1
Delay disc. indifference point, 2s delay	0.5	0.6	1.1	-1.0	-0.4
Delay disc. indifference point, 24s delay	0.9	0.9	1.6	-1.3	0.4
Delay disc. indifference point, 4s delay	4.9	5.2	8.8	-3.0	1.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	-0.7	-0.3
Delay discount exponential model param	1.6	1.6	3.1	1.8	-0.5
Delay discount hyperbolic model param	1.7	1.8	3.5	1.9	-0.4
Fecal boli incidents, locomotor time 1	1.1	1.2	2.4	1.5	-0.4
Change in fecal boli incidents, locomotor task	0.7	0.7	1.2	-1.1	0.4
Time >=10cm from walls, locomotor time 1	0.8	0.8	0.9	0.9	-0.9
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.4	0.6
Total resting periods, locomotor time 1	0.4	0.4	0.6	-0.5	0.8
Rest time, locomotor task time 1	0.0	0.0	0.0	0.0	0.2
Distance moved, locomotor task time 1	0.4	0.4	0.8	-0.9	0.0
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.3	-0.0
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.6	0.2	-0.8
Bouts of movement, locomotor time 2	0.2	0.3	0.3	0.6	-0.4
Total resting periods, locomotor time 2	0.3	0.3	0.4	0.7	-0.3
Rest time, locomotor task time 2	0.3	0.3	0.6	0.3	0.8
Distance moved, locomotor task time 2	1.7	1.9	3.3	-1.8	0.7
Vertical activity count, locomotor time 2	1.2	1.3	2.3	-1.5	0.6
Weight adjusted by age	0.2	0.2	0.4	-0.3	0.6
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.6	0.8	-0.4
Locomotion in novel chamber	0.4	0.5	0.7	-0.6	-0.8
Locomotion in novel chamber post-restriction	2.4	2.9	3.4	1.8	-1.5
Progressive ratio	0.1	0.1	0.1	-0.3	0.1
Food seeking constrained by brief footshock	0.4	0.4	0.5	0.7	-0.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	-0.4
Run reversals in cocaine runway, females	1.6	1.6	2.0	-1.1	1.4
Run reversals in cocaine runway, males	3.5	3.4	4.1	2.0	-1.6
Latency to leave start box in cocaine runway	0.7	0.8	0.8	0.9	0.8
Latency to leave start box in cocaine runway, F	0.6	0.7	0.8	0.9	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.4	0.3
Cd content in liver	0.1	0.1	0.1	-0.1	-0.4
Co content in liver	0.4	0.5	0.8	-0.3	0.9
Cu content in liver	0.9	1.0	1.4	-0.8	1.2
Fe content in liver	3.1	3.7	3.9	-1.9	2.0
K content in liver	0.0	0.0	0.1	0.1	-0.3
Mg content in liver	0.0	0.0	0.0	-0.2	-0.0
Mn content in liver	0.1	0.1	0.2	-0.0	-0.4
Na content in liver	1.2	1.3	1.7	1.3	-1.0
Rb content in liver	0.7	0.9	0.9	0.9	-1.0
Se content in liver	0.6	0.7	1.3	0.4	-1.2
Sr content in liver	1.6	1.5	2.1	-1.4	0.9
Zn content in liver	1.4	1.6	2.2	1.0	-1.5