| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | gene expression | ENSRNOG00000052725 | 0.406 | 0.1809 | 1.1e-08 | 0.066 | 0.152 | 0.161 | 0.155 | 1.9e-04 | 1.6e-08 | 5.5e-09 | 1.2e-08 |
| 2 | BLA | mRNA stability | ENSRNOG00000052725 | 0.180 | 0.0970 | 1.4e-07 | 0.065 | 0.106 | 0.101 | 0.099 | 2.3e-04 | 2.8e-06 | 4.8e-06 | 5.8e-06 |
| 3 | Brain | gene expression | ENSRNOG00000052725 | 0.240 | 0.1200 | 1.8e-13 | 0.143 | 0.152 | 0.160 | 0.166 | 3.8e-13 | 5.3e-14 | 1.2e-14 | 3.5e-15 |
| 4 | Brain | mRNA stability | ENSRNOG00000052725 | 0.270 | 0.1046 | 9.4e-16 | 0.158 | 0.163 | 0.155 | 0.159 | 1.6e-14 | 5.6e-15 | 3.3e-14 | 1.4e-14 |
| 5 | LHb | gene expression | ENSRNOG00000052725 | 0.188 | 0.1049 | 3.6e-04 | 0.113 | 0.136 | 0.050 | 0.054 | 1.3e-03 | 4.1e-04 | 2.6e-02 | 2.1e-02 |
| 6 | Liver | gene expression | ENSRNOG00000052725 | 0.200 | 0.0880 | 0.0e+00 | 0.140 | 0.111 | 0.147 | 0.147 | 2.7e-15 | 2.3e-12 | 5.5e-16 | 4.8e-16 |
| 7 | NAcc | mRNA stability | ENSRNOG00000052725 | 0.155 | 0.0936 | 1.0e-05 | 0.058 | 0.046 | 0.056 | 0.061 | 3.9e-05 | 2.3e-04 | 5.3e-05 | 2.7e-05 |
| 8 | PL | gene expression | ENSRNOG00000052725 | 0.125 | 0.0723 | 2.3e-06 | 0.085 | 0.070 | 0.071 | 0.073 | 5.1e-07 | 5.2e-06 | 4.6e-06 | 3.0e-06 |
| 9 | PL | mRNA stability | ENSRNOG00000052725 | 0.190 | 0.0878 | 1.3e-08 | 0.097 | 0.098 | 0.101 | 0.113 | 7.7e-08 | 7.4e-08 | 4.0e-08 | 6.6e-09 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Left kidney weight | 7.6 | 21.9 | 44.1 | 0.3 | 5.9 | -6.4 | 3.3 | 6.6 | 4.2 | 4.6 | -3.7 | 3.7 |
| Right kidney weight | 7.6 | 21.8 | 48.6 | 0.9 | 5.8 | -6.4 | 3.0 | 7.0 | 4.8 | 4.3 | -3.3 | 3.3 |
| Locomotion velocity, session 8 | 4.9 | 5.9 | 11.9 | 0.2 | 3.0 | -3.4 | 1.8 | 3.4 | 2.3 | 2.3 | -1.8 | 1.8 |
| Stereotopy head waving bouts, day 7 | 4.8 | 5.4 | 8.8 | -1.1 | 3.0 | -2.9 | 2.6 | 2.1 | 0.6 | 2.7 | -2.4 | 2.4 |
| Diff in mean of infusions in LGA sessions | 4.7 | 5.3 | 8.2 | 2.3 | -2.4 | 1.9 | -2.8 | -0.2 | 1.3 | -2.7 | 2.9 | -2.8 |
| Bone: endosteal perimeter | 4.1 | 8.5 | 13.9 | -2.6 | 3.4 | -2.8 | 3.7 | 1.3 | -1.1 | 3.5 | -3.3 | 3.3 |
| Locomotion velocity, session 2 | 3.9 | 4.6 | 7.2 | -1.4 | 2.6 | -2.7 | 2.1 | 1.6 | 0.1 | 2.5 | -2.4 | 2.4 |
| Bone: elastic work | 3.9 | 5.1 | 8.6 | -0.8 | 2.9 | -2.9 | 2.3 | 2.3 | 1.0 | 2.6 | -2.3 | 2.3 |
| Delta time in open arm before/after self-admin | 3.7 | 3.6 | 5.4 | -1.9 | 2.0 | -1.7 | 2.3 | 0.2 | -1.0 | 2.3 | -2.2 | 2.3 |
| Bone: endosteal estimation | 3.5 | 7.5 | 11.8 | -1.7 | 3.4 | -3.2 | 3.1 | 2.2 | 0.2 | 3.3 | -3.0 | 3.0 |
| Bone: marrow area | 3.5 | 7.5 | 11.9 | -1.6 | 3.4 | -3.3 | 3.1 | 2.2 | 0.3 | 3.3 | -2.9 | 2.9 |
| Bone: maximum diameter | 3.5 | 6.4 | 10.5 | -1.0 | 3.2 | -3.1 | 2.9 | 2.5 | 0.7 | 3.0 | -2.5 | 2.5 |
| Bone: periosteal perimeter | 3.3 | 5.4 | 10.0 | -2.0 | 2.7 | -2.2 | 3.2 | 1.1 | -0.8 | 2.8 | -2.6 | 2.6 |
| Pavlov. Cond. magazine entry number | 3.2 | 4.0 | 6.5 | -1.0 | 2.6 | -2.5 | 2.0 | 1.8 | 0.6 | 2.3 | -2.1 | 2.1 |
| Pavlov. Cond. magazine entry latency | 3.1 | 4.0 | 6.5 | 1.1 | -2.5 | 2.5 | -2.1 | -1.8 | -0.4 | -2.3 | 2.1 | -2.1 |
| Stereotopy head waving duration, day 7 | 3.0 | 3.6 | 5.6 | -1.3 | 2.4 | -2.1 | 2.3 | 1.3 | -0.0 | 2.3 | -2.1 | 2.1 |
| Degree of sensitization stereotypy | 3.0 | 3.3 | 5.3 | -1.2 | 2.3 | -2.0 | 2.3 | 1.3 | -0.0 | 2.2 | -1.9 | 1.9 |
| Pavlov. Cond. response bias | 3.0 | 3.7 | 6.4 | 0.5 | -2.5 | 2.5 | -1.8 | -2.2 | -1.0 | -2.2 | 1.9 | -1.9 |
| Locomotion in novel chamber | 3.0 | 3.7 | 7.7 | -2.8 | 1.1 | -0.5 | 2.1 | -1.5 | -2.2 | 1.8 | -2.2 | 2.1 |
| Light reinforcement 2 | 2.9 | 3.9 | 6.0 | -1.9 | 2.2 | -2.0 | 2.2 | 0.7 | -0.6 | 2.3 | -2.5 | 2.4 |
| Pavlov. Cond. change in total contacts | 2.9 | 3.0 | 5.2 | 0.8 | -2.3 | 2.1 | -1.8 | -1.7 | -0.5 | -2.0 | 1.8 | -1.8 |
| Na content in liver | 2.9 | 3.1 | 6.0 | 0.7 | -2.2 | 2.4 | -1.4 | -1.6 | -0.7 | -2.0 | 2.0 | -1.9 |
| Stereotopy head waving duration, day 3 | 2.8 | 3.4 | 7.0 | -0.0 | 2.3 | -2.7 | 1.4 | 2.4 | 1.5 | 1.9 | -1.6 | 1.6 |
| Social time | 2.7 | 3.5 | 5.7 | 1.2 | -2.4 | 2.0 | -2.3 | -1.6 | -0.3 | -2.3 | 1.8 | -1.9 |
| Cu content in liver | 2.5 | 3.0 | 9.1 | -1.7 | -1.6 | 2.1 | -0.3 | -3.0 | -2.6 | -0.9 | 0.5 | -0.4 |
| Locomotion velocity, session 3 | 2.4 | 2.8 | 4.2 | -1.2 | 2.1 | -2.0 | 1.9 | 1.1 | -0.0 | 2.0 | -1.9 | 1.9 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.4 | 3.0 | 5.0 | 0.7 | -2.2 | 2.2 | -1.7 | -1.8 | -0.7 | -2.0 | 1.8 | -1.8 |
| Time in open arm after self-admin | 2.4 | 2.6 | 3.9 | -1.7 | 1.8 | -1.5 | 1.9 | 0.7 | -0.7 | 2.0 | -1.8 | 1.9 |
| Bone: periosteal estimation | 2.3 | 4.8 | 7.6 | -1.2 | 2.8 | -2.6 | 2.5 | 1.9 | 0.3 | 2.6 | -2.3 | 2.3 |
| Delay discounting water rate 12 sec | 2.2 | 3.3 | 5.5 | -2.0 | 1.9 | -1.6 | 2.3 | 0.1 | -1.1 | 2.1 | -2.0 | 2.1 |
| Bone: minimum diameter | 2.2 | 4.0 | 6.7 | -2.0 | 2.1 | -1.7 | 2.6 | 0.3 | -1.1 | 2.4 | -2.3 | 2.3 |
| Delay discount exponential model param | 2.2 | 2.3 | 3.9 | -0.4 | 1.9 | -1.6 | 1.9 | 1.1 | 0.2 | 2.0 | -1.6 | 1.7 |
| Light reinforcement 1 | 2.1 | 3.8 | 6.0 | -1.7 | 2.1 | -2.1 | 2.1 | 0.5 | -0.3 | 2.5 | -2.3 | 2.4 |
| Short access day 10 total inactive lever presses | 2.1 | 2.3 | 4.5 | -0.1 | 1.9 | -2.1 | 1.0 | 1.9 | 1.7 | 1.4 | -1.2 | 1.2 |
| Pavlov. Cond. index score | 2.1 | 2.7 | 4.5 | 0.8 | -2.1 | 2.0 | -1.7 | -1.5 | -0.4 | -1.9 | 1.7 | -1.7 |
| Delta distance traveled before/after self-admin | 2.1 | 2.2 | 4.0 | -0.9 | 1.8 | -2.0 | 1.5 | 1.0 | 0.5 | 1.7 | -1.7 | 1.6 |
| Delay disc. indifference point, 8s delay | 2.1 | 2.2 | 3.7 | 0.1 | -1.9 | 1.9 | -1.5 | -1.5 | -0.9 | -1.9 | 1.3 | -1.4 |
| Cocaine induced anxiety | 2.0 | 2.3 | 5.5 | 0.5 | 1.8 | -2.0 | 0.8 | 2.3 | 1.7 | 1.3 | -1.1 | 1.1 |
| Baseline Anxiety | 2.0 | 2.1 | 3.8 | -0.2 | -1.8 | 1.8 | -1.2 | -1.9 | -1.4 | -1.4 | 1.3 | -1.2 |
| Area under the delay curve | 2.0 | 2.2 | 3.7 | 0.3 | -1.9 | 1.7 | -1.8 | -1.2 | -0.3 | -1.9 | 1.5 | -1.6 |
| BMI without tail | 1.9 | 4.0 | 6.5 | -1.6 | 2.4 | -2.1 | 2.1 | 1.2 | -0.5 | 2.2 | -2.5 | 2.4 |
| Indifference point function ln k | 1.9 | 2.6 | 3.9 | -1.3 | 1.9 | -1.6 | 1.9 | 0.8 | -0.3 | 2.0 | -1.9 | 1.9 |
| Indifference point function log k | 1.9 | 2.6 | 3.9 | -1.3 | 1.9 | -1.6 | 1.9 | 0.8 | -0.3 | 2.0 | -1.9 | 1.9 |
| Context. condit. distance diff. score | 1.9 | 2.3 | 5.0 | 0.0 | 2.0 | -2.0 | 1.4 | 2.2 | 1.3 | 1.5 | -1.1 | 1.1 |
| Delay disc. indifference point, 16s delay | 1.9 | 1.9 | 3.2 | 0.0 | -1.8 | 1.7 | -1.6 | -1.5 | -0.8 | -1.8 | 1.1 | -1.2 |
| Intermitt. access day 15 inactive lever presses | 1.7 | 1.9 | 5.8 | 2.1 | 0.0 | -0.6 | -1.1 | 1.8 | 2.4 | -0.7 | 0.9 | -0.9 |
| Intermittent access day 15 total locomotion | 1.7 | 1.9 | 2.9 | -1.2 | 1.4 | -1.3 | 1.7 | 0.2 | -0.5 | 1.6 | -1.7 | 1.7 |
| Incentive Sensitization - Breakpoint | 1.7 | 1.7 | 5.6 | 1.6 | 0.6 | -1.1 | -0.6 | 2.2 | 2.4 | 0.1 | 0.4 | -0.3 |
| Bone: post-yield work | 1.7 | 2.3 | 4.6 | 2.2 | -1.0 | 0.8 | -1.6 | 0.8 | 1.6 | -1.4 | 1.8 | -1.8 |
| Run reversals in cocaine runway, females | 1.7 | 1.7 | 5.1 | -1.8 | -0.2 | 0.5 | 0.6 | -2.1 | -2.2 | 0.6 | -0.9 | 0.9 |
| Mean num. licks in bursts | 1.6 | 1.9 | 6.4 | 1.6 | 0.8 | -1.4 | -0.6 | 2.3 | 2.5 | 0.1 | 0.2 | -0.2 |
| Conditioned locomotion | 1.6 | 1.9 | 3.2 | -0.7 | 1.6 | -1.8 | 1.4 | 0.8 | 0.4 | 1.6 | -1.6 | 1.6 |
| Condit. Reinf. active minus inactive responses | 1.6 | 1.7 | 3.1 | 0.6 | -1.7 | 1.7 | -1.3 | -1.2 | -0.5 | -1.5 | 1.4 | -1.4 |
| Bone: cortical apparent density | 1.6 | 2.0 | 3.5 | 1.1 | -1.7 | 1.4 | -1.9 | -0.7 | 0.5 | -1.7 | 1.6 | -1.6 |
| Bone: elastic displacement | 1.6 | 1.8 | 2.7 | -0.9 | 1.7 | -1.5 | 1.6 | 0.9 | 0.2 | 1.6 | -1.5 | 1.5 |
| Delay discount hyperbolic model param | 1.6 | 1.7 | 3.0 | -0.3 | 1.7 | -1.4 | 1.7 | 0.9 | 0.1 | 1.7 | -1.4 | 1.5 |
| Total resting periods, locomotor time 2 | 1.6 | 1.7 | 2.7 | 1.5 | -1.3 | 1.4 | -1.5 | -0.2 | 0.4 | -1.7 | 1.4 | -1.5 |
| Glucose | 1.5 | 2.3 | 3.8 | 0.8 | -1.9 | 1.9 | -1.6 | -1.4 | -0.3 | -1.7 | 1.7 | -1.7 |
| Incentive Sensitization - Responses | 1.5 | 1.5 | 4.9 | 1.5 | 0.5 | -1.0 | -0.7 | 2.0 | 2.2 | 0.1 | 0.5 | -0.4 |
| Incentive salience index mean | 1.5 | 1.9 | 3.3 | 0.4 | -1.8 | 1.8 | -1.3 | -1.4 | -0.8 | -1.6 | 1.3 | -1.3 |
| Short access day 1 total inactive lever presses | 1.4 | 1.5 | 3.5 | 0.6 | 1.3 | -1.7 | 0.7 | 1.7 | 1.9 | 0.8 | -0.7 | 0.7 |
| Condit. Reinf. active responses | 1.4 | 1.7 | 3.1 | -0.1 | -1.6 | 1.8 | -1.1 | -1.7 | -1.2 | -1.3 | 1.0 | -1.0 |
| Bone: cortical tissue density | 1.4 | 1.8 | 3.3 | 1.1 | -1.6 | 1.3 | -1.8 | -0.6 | 0.6 | -1.6 | 1.5 | -1.5 |
| Vertical activity count, locomotor time 2 | 1.4 | 1.6 | 2.6 | -0.9 | 1.5 | -1.5 | 1.4 | 0.9 | 0.2 | 1.6 | -1.3 | 1.4 |
| Water consumed over 24 hours | 1.3 | 1.5 | 4.0 | 0.9 | 1.3 | -1.5 | 0.7 | 2.0 | 1.8 | 0.9 | -0.4 | 0.4 |
| Stereotopy head waving bouts, day 3 | 1.3 | 1.5 | 3.6 | 0.3 | 1.4 | -1.9 | 0.4 | 1.7 | 1.4 | 1.1 | -0.9 | 0.9 |
| Degree of sensitization distance | 1.3 | 1.3 | 3.8 | 1.7 | -0.1 | -0.3 | -1.2 | 1.4 | 1.9 | -0.7 | 0.9 | -0.9 |
| Pavlov. Cond. latency score | 1.3 | 1.6 | 2.8 | 0.5 | -1.7 | 1.6 | -1.2 | -1.4 | -0.4 | -1.5 | 1.3 | -1.3 |
| Delta ambulatory time before/after self-admin | 1.3 | 1.5 | 2.5 | -0.8 | 1.5 | -1.6 | 1.3 | 1.0 | 0.5 | 1.4 | -1.2 | 1.2 |
| Food consumed during 24 hour testing period | 1.2 | 1.5 | 5.0 | 1.5 | 0.8 | -1.2 | -0.1 | 2.0 | 2.2 | 0.3 | 0.3 | -0.3 |
| Delay discounting water rate 24 sec | 1.2 | 1.7 | 3.1 | -0.6 | 1.6 | -1.8 | 1.2 | 1.1 | 0.5 | 1.5 | -1.4 | 1.4 |
| Cocaine response after cond. not corrected | 1.2 | 1.3 | 2.4 | -1.5 | 0.7 | -0.2 | 1.5 | -0.7 | -1.5 | 1.1 | -1.1 | 1.1 |
| Intermittent access total locomotion | 1.2 | 1.4 | 2.1 | -0.7 | 1.4 | -1.4 | 1.3 | 0.7 | 0.0 | 1.4 | -1.4 | 1.4 |
| Delta time in closed arm before/after self-admin | 1.2 | 1.2 | 2.1 | 1.2 | -0.8 | 0.4 | -1.5 | 0.4 | 1.3 | -1.1 | 1.1 | -1.2 |
| Reaction time premature initiation rate | 1.1 | 1.5 | 3.5 | 1.7 | -0.3 | -0.2 | -1.3 | 1.4 | 1.9 | -0.7 | 1.1 | -1.1 |
| One hour access (shock baseline) | 1.1 | 1.3 | 2.4 | -1.5 | 0.7 | -0.2 | 1.4 | -0.7 | -1.3 | 1.2 | -1.2 | 1.3 |
| Number of responses in last shaping day | 1.1 | 1.1 | 1.7 | 0.9 | -1.3 | 1.0 | -1.3 | -0.8 | 0.2 | -1.3 | 1.2 | -1.2 |
| Locomotion distance, session 8 | 1.1 | 1.7 | 3.2 | -0.3 | 1.7 | -1.8 | 1.1 | 1.7 | 0.9 | 1.4 | -1.1 | 1.1 |
| Pavlov. Cond. lever contacts | 1.1 | 1.3 | 3.2 | -0.2 | -1.5 | 1.5 | -0.8 | -1.8 | -1.0 | -1.1 | 0.8 | -0.8 |
| Delay disc. indifference point, 4s delay | 1.1 | 1.2 | 2.6 | 0.8 | -1.0 | 0.7 | -1.6 | 0.0 | 0.9 | -1.2 | 1.3 | -1.3 |
| Bouts of movement, locomotor time 2 | 1.1 | 1.2 | 1.9 | 1.2 | -1.2 | 1.2 | -1.3 | -0.3 | 0.2 | -1.4 | 1.1 | -1.2 |
| Distance moved, locomotor task time 2 | 1.1 | 1.3 | 1.9 | -0.8 | 1.4 | -1.2 | 1.4 | 0.8 | 0.1 | 1.4 | -1.2 | 1.2 |
| Progressive ratio | 1.1 | 1.3 | 2.1 | 0.8 | -1.3 | 1.2 | -1.2 | -0.3 | 0.4 | -1.4 | 1.4 | -1.4 |
| Mean time between licks in bursts | 1.0 | 1.5 | 3.7 | -0.5 | -1.3 | 1.7 | -0.3 | -1.9 | -1.6 | -0.9 | 0.7 | -0.7 |
| Locomotor activity | 1.0 | 1.6 | 3.2 | -0.3 | 1.6 | -1.8 | 1.3 | 1.3 | 0.6 | 1.5 | -1.1 | 1.1 |
| Median of all reaction times | 1.0 | 1.4 | 2.1 | 0.9 | -1.4 | 1.4 | -1.3 | -0.6 | 0.2 | -1.3 | 1.4 | -1.4 |
| Reaction time omissions | 1.0 | 1.3 | 2.1 | 0.7 | -1.4 | 1.4 | -1.0 | -0.7 | -0.4 | -1.3 | 1.4 | -1.4 |
| Post-drug Anxiety | 1.0 | 1.1 | 3.2 | 0.6 | 1.1 | -1.5 | 0.2 | 1.8 | 1.3 | 0.5 | -0.5 | 0.4 |
| Compulsive drug intake | 1.0 | 1.0 | 1.7 | 1.2 | -0.7 | 0.4 | -1.0 | 0.5 | 1.3 | -1.1 | 1.1 | -1.1 |
| Locomotion velocity, session 1 | 1.0 | 1.1 | 2.6 | 0.3 | 1.2 | -1.6 | 0.5 | 1.5 | 1.2 | 0.9 | -0.7 | 0.7 |
| Locomotion distance, session 3 | 1.0 | 1.1 | 2.2 | -1.5 | 0.5 | -0.2 | 1.1 | -0.8 | -1.5 | 0.8 | -1.0 | 1.0 |
| Condit. Reinf. active-inactive response ratio | 1.0 | 1.0 | 1.9 | 0.6 | -1.2 | 1.4 | -0.9 | -0.7 | -0.3 | -1.1 | 1.2 | -1.2 |
| Total zone transitions, hab. session 1 | 1.0 | 1.5 | 2.5 | 0.3 | -1.6 | 1.5 | -1.2 | -1.4 | -0.6 | -1.4 | 1.1 | -1.1 |
| Bone: maximum moment | 1.0 | 1.8 | 6.0 | 1.4 | 1.1 | -1.4 | 0.1 | 2.4 | 2.1 | 0.5 | -0.0 | -0.0 |
| Weight adjusted by age | 1.0 | 1.1 | 1.8 | -0.9 | 1.1 | -1.3 | 1.0 | 0.7 | -0.2 | 1.1 | -1.3 | 1.2 |
| Latency to leave start box in cocaine runway | 1.0 | 1.1 | 2.0 | -0.2 | 1.3 | -1.4 | 0.8 | 1.1 | 0.8 | 1.0 | -1.1 | 1.0 |
| Latency to leave start box in cocaine runway, M | 1.0 | 1.0 | 1.8 | -0.3 | 1.3 | -1.3 | 0.8 | 1.3 | 0.9 | 0.9 | -0.8 | 0.8 |
| BMI with tail | 0.9 | 2.9 | 8.0 | 0.7 | 2.0 | -2.2 | 0.8 | 2.8 | 2.1 | 1.3 | -1.0 | 1.0 |
| Pavlov. Cond. magazine entry latency | 0.9 | 1.1 | 2.6 | 0.8 | -1.3 | 0.9 | -1.6 | -0.6 | 0.3 | -1.4 | 0.9 | -0.9 |
| Progressive ratio test 2 breakpoint | 0.9 | 1.0 | 2.8 | 1.5 | -0.2 | -0.1 | -0.8 | 1.2 | 1.7 | -0.6 | 1.0 | -0.9 |
| Pavlov. Cond. lever latency | 0.9 | 1.1 | 2.5 | 0.1 | 1.4 | -1.3 | 0.8 | 1.6 | 0.9 | 1.1 | -0.7 | 0.7 |
| Delay disc. indifference point, 24s delay | 0.9 | 0.8 | 2.0 | 0.4 | -1.1 | 1.0 | -1.0 | -0.3 | 0.1 | -1.4 | 0.9 | -1.0 |
| Seeking ratio, delayed vs. immediate footshock | 0.9 | 1.0 | 3.0 | -0.5 | -0.9 | 1.4 | -0.0 | -1.7 | -1.6 | -0.7 | -0.0 | -0.2 |
| Conditioned reinforcement - actives | 0.8 | 0.8 | 1.2 | 0.8 | -1.1 | 1.0 | -0.9 | -0.6 | 0.2 | -1.1 | 1.1 | -1.1 |
| Intermitt. access day 1 inactive lever presses | 0.8 | 0.9 | 2.4 | 0.7 | 0.9 | -1.4 | 0.1 | 1.5 | 1.5 | 0.3 | -0.5 | 0.3 |
| Progressive ratio test 2 active lever presses | 0.8 | 0.8 | 2.5 | 1.3 | -0.2 | -0.2 | -0.8 | 1.1 | 1.6 | -0.4 | 0.8 | -0.7 |
| Progressive ratio test 2 inactive lever presses | 0.8 | 1.0 | 2.6 | 1.4 | -0.3 | -0.1 | -0.8 | 1.1 | 1.6 | -0.8 | 0.9 | -0.9 |
| Time in novel zone, NPP test | 0.8 | 0.9 | 1.7 | -0.3 | 1.2 | -1.0 | 1.3 | 1.0 | 0.2 | 1.2 | -0.8 | 0.8 |
| Bone: cortical thickness | 0.8 | 1.4 | 2.0 | 1.4 | -1.2 | 1.0 | -1.4 | -0.1 | 0.7 | -1.3 | 1.4 | -1.4 |
| Bone: final moment | 0.8 | 1.4 | 4.1 | 1.7 | 0.3 | -0.7 | -0.7 | 1.9 | 2.0 | -0.2 | 0.6 | -0.6 |
| Bone: maximum force | 0.8 | 1.3 | 4.4 | 1.2 | 0.9 | -1.2 | 0.0 | 2.1 | 1.9 | 0.4 | 0.0 | -0.0 |
| Bone: trabecular spacing | 0.8 | 1.0 | 3.1 | 0.4 | 1.1 | -1.4 | 0.4 | 1.8 | 1.1 | 0.7 | -0.6 | 0.6 |
| Time in closed arm before self-admin | 0.8 | 0.9 | 2.3 | -0.3 | -1.1 | 1.2 | -0.5 | -1.5 | -1.3 | -0.9 | 0.4 | -0.4 |
| Time to tail flick, test, after self-admin | 0.8 | 0.9 | 1.8 | -0.1 | -1.2 | 1.1 | -0.9 | -1.3 | -0.8 | -0.9 | 0.8 | -0.8 |
| Delta time to tail flick, test, before/after SA | 0.8 | 0.7 | 1.2 | 0.2 | -1.1 | 1.0 | -0.9 | -1.0 | -0.3 | -1.0 | 0.7 | -0.8 |
| Co content in liver | 0.8 | 1.0 | 2.0 | -0.1 | 1.2 | -1.4 | 0.9 | 0.7 | 0.4 | 1.2 | -1.2 | 1.1 |
| Delay discounting total patch changes 6 sec | 0.7 | 1.1 | 1.6 | 1.2 | -1.1 | 1.0 | -1.0 | -0.2 | 0.9 | -1.3 | 1.2 | -1.2 |
| Reaction time premature initiations | 0.7 | 1.0 | 1.8 | 1.4 | -0.7 | 0.3 | -1.2 | 0.8 | 1.2 | -0.9 | 1.2 | -1.1 |
| Pavlov. Cond. change in total contacts | 0.7 | 1.0 | 2.4 | 1.5 | -0.5 | -0.2 | -1.3 | 0.8 | 1.5 | -0.8 | 0.7 | -0.7 |
| Novelty place preference | 0.7 | 0.7 | 1.3 | -0.3 | 1.1 | -0.9 | 1.1 | 0.9 | 0.2 | 1.0 | -0.7 | 0.7 |
| Bone: stiffness | 0.7 | 1.1 | 2.4 | 1.5 | -0.8 | 0.7 | -1.0 | 0.6 | 1.1 | -1.0 | 1.3 | -1.3 |
| Delay disc. indifference point, 2s delay | 0.7 | 0.8 | 1.4 | 0.3 | -1.1 | 0.9 | -1.2 | -0.6 | 0.0 | -0.9 | 1.2 | -1.1 |
| Body weight | 0.6 | 2.7 | 4.7 | -0.2 | 2.2 | -2.0 | 1.7 | 2.1 | 0.9 | 1.7 | -1.5 | 1.5 |
| Times rat made contact with spout | 0.6 | 0.7 | 2.6 | 1.0 | 0.3 | -0.7 | -0.4 | 1.3 | 1.6 | -0.0 | 0.2 | -0.3 |
| Indifference point AUC | 0.6 | 0.7 | 1.1 | 0.9 | -0.8 | 0.7 | -1.1 | -0.0 | 0.6 | -1.0 | 1.1 | -1.0 |
| Delay discounting total patch changes 12 sec | 0.6 | 0.8 | 1.6 | 1.3 | -0.6 | 0.5 | -0.9 | 0.5 | 1.1 | -0.9 | 1.0 | -1.0 |
| Delay discounting total patch changes 18 sec | 0.6 | 0.8 | 1.2 | 0.7 | -1.1 | 1.0 | -1.0 | -0.8 | 0.3 | -0.9 | 1.0 | -1.0 |
| Reaction time mean | 0.6 | 0.8 | 1.4 | 0.6 | -1.1 | 1.2 | -0.9 | -0.5 | 0.1 | -0.9 | 1.1 | -1.1 |
| Reaction time mean AUC | 0.6 | 0.8 | 1.4 | 0.6 | -1.1 | 1.2 | -0.9 | -0.5 | 0.2 | -1.0 | 1.2 | -1.1 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.8 | 1.2 | 1.1 | -0.7 | 0.4 | -0.9 | 0.4 | 1.0 | -0.9 | 1.0 | -1.0 |
| Condit. Reinf. inactive responses | 0.6 | 0.8 | 2.5 | 1.1 | 0.5 | -0.9 | -0.2 | 1.6 | 1.6 | 0.0 | -0.0 | -0.0 |
| Total sessions with >9 infusions | 0.6 | 0.6 | 1.5 | -0.9 | 0.7 | -0.5 | 1.2 | -0.1 | -0.6 | 0.8 | -0.9 | 0.9 |
| Locomotion velocity, session 7 | 0.6 | 0.7 | 1.1 | -0.8 | 0.9 | -0.7 | 1.0 | 0.5 | -0.4 | 0.9 | -0.9 | 0.9 |
| Time in familiar zone, hab. session 1 | 0.6 | 0.5 | 1.0 | -0.2 | 0.9 | -1.0 | 0.6 | 0.8 | 0.4 | 0.8 | -0.7 | 0.7 |
| Bone: final force | 0.6 | 1.0 | 3.0 | 1.5 | 0.1 | -0.5 | -0.8 | 1.5 | 1.7 | -0.3 | 0.7 | -0.7 |
| Bone: trabecular tissue density | 0.6 | 0.9 | 1.7 | 0.9 | -1.0 | 0.7 | -1.3 | -0.3 | 0.6 | -1.1 | 1.0 | -1.0 |
| Change in fecal boli incidents, locomotor task | 0.6 | 0.5 | 1.2 | -0.8 | 0.6 | -0.3 | 1.1 | -0.2 | -0.9 | 0.7 | -0.8 | 0.8 |
| Seeking ratio, punishment vs. effort | 0.6 | 0.8 | 1.5 | -0.0 | 1.1 | -1.2 | 0.7 | 0.7 | 0.3 | 1.1 | -0.9 | 1.0 |
| Run reversals in cocaine runway, males | 0.6 | 0.5 | 1.3 | -0.3 | 0.9 | -0.6 | 1.1 | 0.4 | -0.1 | 1.0 | -0.7 | 0.8 |
| Mn content in liver | 0.6 | 0.7 | 1.4 | -0.3 | 1.0 | -1.2 | 0.6 | 0.6 | 0.3 | 0.8 | -1.0 | 1.0 |
| Length without tail | 0.5 | 1.2 | 3.4 | 1.7 | -0.3 | -0.2 | -0.9 | 1.1 | 1.8 | -0.6 | 1.1 | -1.0 |
| Retroperitoneal fat weight | 0.5 | 1.8 | 3.7 | 0.0 | 1.7 | -1.9 | 0.8 | 1.8 | 1.1 | 1.3 | -1.1 | 1.1 |
| Cocaine response after cond. corrected | 0.5 | 0.6 | 1.1 | -1.0 | 0.5 | -0.1 | 0.9 | -0.5 | -1.0 | 0.7 | -0.8 | 0.8 |
| Saline control response | 0.5 | 0.7 | 1.1 | -1.0 | 0.5 | -0.3 | 1.0 | -0.6 | -0.9 | 0.8 | -0.9 | 0.9 |
| Condit. Reinf. active responses | 0.5 | 0.8 | 2.5 | 1.2 | 0.1 | -0.5 | -0.5 | 1.4 | 1.6 | -0.3 | 0.5 | -0.5 |
| Condit. Reinf. lever reinforcers received | 0.5 | 0.7 | 1.8 | 1.1 | -0.3 | -0.1 | -0.8 | 1.0 | 1.4 | -0.7 | 0.7 | -0.7 |
| Condit. Reinf. lever presses | 0.5 | 0.7 | 1.3 | -0.1 | -1.0 | 1.0 | -0.7 | -1.1 | -0.8 | -0.9 | 0.6 | -0.6 |
| Total locomotion distance, NPP test | 0.5 | 0.7 | 1.2 | -0.8 | 0.9 | -1.0 | 0.8 | 0.2 | -0.1 | 0.9 | -1.1 | 1.1 |
| Bone: cortical thickness | 0.5 | 0.6 | 1.2 | 1.1 | -0.5 | 0.3 | -0.9 | 0.5 | 0.9 | -0.7 | 1.0 | -0.9 |
| Ambulatory time before self-admin | 0.5 | 0.6 | 1.3 | 1.1 | -0.5 | 0.3 | -0.7 | 0.4 | 1.0 | -0.8 | 0.7 | -0.8 |
| Total resting periods, locomotor time 1 | 0.5 | 0.6 | 1.4 | 0.7 | -0.8 | 0.6 | -1.2 | -0.1 | 0.4 | -1.0 | 0.8 | -0.9 |
| Extensor digitorum longus weight | 0.4 | 1.5 | 2.3 | -1.2 | 1.4 | -1.3 | 1.3 | 0.5 | -0.4 | 1.4 | -1.5 | 1.5 |
| Number of licking bursts | 0.4 | 0.5 | 1.5 | -0.8 | -0.4 | 0.8 | 0.4 | -1.2 | -1.2 | -0.1 | -0.0 | 0.0 |
| Reaction time number correct | 0.4 | 0.6 | 1.6 | -0.5 | -0.8 | 0.9 | -0.1 | -1.2 | -1.3 | -0.4 | 0.3 | -0.3 |
| Reaction time trials correct on left | 0.4 | 0.6 | 1.6 | -0.5 | -0.8 | 0.9 | -0.1 | -1.2 | -1.3 | -0.4 | 0.3 | -0.3 |
| Reaction time trials on left | 0.4 | 0.6 | 1.6 | -0.5 | -0.8 | 1.0 | -0.1 | -1.2 | -1.3 | -0.5 | 0.4 | -0.4 |
| Reaction time trials completed | 0.4 | 0.6 | 1.6 | -0.5 | -0.8 | 1.0 | -0.1 | -1.2 | -1.3 | -0.5 | 0.4 | -0.4 |
| Pavlov. Cond. index score | 0.4 | 0.5 | 1.4 | 0.7 | -0.8 | 0.3 | -1.2 | -0.1 | 0.5 | -0.9 | 0.5 | -0.5 |
| Pavlov. Cond. latency score | 0.4 | 0.5 | 1.4 | 0.7 | -0.8 | 0.3 | -1.2 | -0.1 | 0.5 | -0.9 | 0.5 | -0.5 |
| Pavlov. Cond. magazine entry number | 0.4 | 0.5 | 1.6 | -0.8 | 0.8 | -0.3 | 1.3 | 0.2 | -0.6 | 1.0 | -0.5 | 0.6 |
| Pavlov. Cond. intertrial magazine entries | 0.4 | 0.5 | 1.6 | 0.8 | 0.3 | -0.3 | -0.1 | 1.3 | 1.2 | 0.0 | 0.5 | -0.5 |
| Pavlov. Cond. response bias | 0.4 | 0.6 | 1.3 | 1.0 | -0.6 | 0.1 | -1.1 | 0.3 | 0.9 | -0.8 | 0.6 | -0.6 |
| Lifetime Intake | 0.4 | 0.4 | 0.7 | -0.1 | 0.8 | -0.7 | 0.9 | 0.7 | 0.6 | 0.7 | -0.6 | 0.6 |
| Short access day 1 total infusions | 0.4 | 0.5 | 1.1 | 0.3 | 0.8 | -1.1 | 0.6 | 0.8 | 0.8 | 0.5 | -0.5 | 0.4 |
| Locomotion distance, session 2 | 0.4 | 0.5 | 1.3 | 0.8 | -0.7 | 0.3 | -1.1 | 0.0 | 0.6 | -0.8 | 0.8 | -0.8 |
| Total locomotion distance, hab. session 1 | 0.4 | 0.6 | 1.0 | -1.0 | 0.6 | -0.6 | 0.7 | -0.3 | -0.6 | 0.8 | -1.0 | 1.0 |
| Locomotion velocity, hab. session 1 | 0.4 | 0.6 | 1.0 | -0.9 | 0.7 | -0.8 | 0.6 | -0.2 | -0.5 | 0.7 | -1.0 | 1.0 |
| Total zone transitions, hab. session 2 | 0.4 | 0.5 | 1.7 | 0.9 | 0.1 | -0.6 | -0.6 | 0.9 | 1.3 | -0.3 | 0.3 | -0.3 |
| Bone: cortical porosity | 0.4 | 0.5 | 0.7 | -0.4 | 0.8 | -0.8 | 0.8 | 0.5 | -0.0 | 0.8 | -0.8 | 0.7 |
| Distance traveled before self-admin | 0.4 | 0.4 | 0.7 | 0.8 | -0.6 | 0.4 | -0.7 | 0.1 | 0.6 | -0.7 | 0.7 | -0.7 |
| Zn content in liver | 0.4 | 0.5 | 1.5 | -0.6 | -0.6 | 0.8 | -0.1 | -1.2 | -1.1 | -0.4 | 0.2 | -0.2 |
| Soleus weight | 0.3 | 0.9 | 2.1 | 1.4 | -0.2 | -0.1 | -0.9 | 1.1 | 1.4 | -0.6 | 0.9 | -0.8 |
| Std. dev. time between licks in bursts | 0.3 | 0.4 | 0.7 | 0.2 | -0.9 | 0.8 | -0.7 | -0.5 | -0.1 | -0.8 | 0.6 | -0.6 |
| Delay discounting total patch changes 24 sec | 0.3 | 0.4 | 0.7 | -0.8 | 0.5 | -0.4 | 0.7 | -0.3 | -0.4 | 0.6 | -0.9 | 0.8 |
| Locomotor testing rearing | 0.3 | 0.5 | 0.8 | -0.7 | 0.8 | -0.8 | 0.9 | 0.3 | -0.2 | 0.9 | -0.7 | 0.7 |
| Reaction time trials AUC | 0.3 | 0.4 | 1.4 | -0.6 | -0.6 | 0.7 | 0.0 | -1.0 | -1.2 | -0.3 | 0.2 | -0.2 |
| Conditioned locomotion | 0.3 | 0.3 | 1.0 | -0.3 | -0.5 | 0.8 | 0.1 | -0.7 | -1.0 | -0.3 | 0.3 | -0.3 |
| Condit. Reinf. active-inactive response ratio | 0.3 | 0.3 | 0.6 | 0.6 | -0.4 | 0.2 | -0.5 | 0.2 | 0.6 | -0.5 | 0.7 | -0.7 |
| Intermittent access intake escalation | 0.3 | 0.3 | 1.1 | -0.6 | -0.2 | 0.4 | 0.2 | -0.8 | -1.1 | 0.1 | -0.2 | 0.2 |
| Intermittent access intake escalation 2 | 0.3 | 0.3 | 0.5 | 0.1 | -0.7 | 0.7 | -0.4 | -0.6 | -0.3 | -0.4 | 0.6 | -0.6 |
| Intermittent access standard deviation | 0.3 | 0.3 | 0.8 | 0.2 | 0.6 | -0.8 | 0.1 | 0.9 | 0.8 | 0.5 | -0.2 | 0.2 |
| Progressive ratio test 1 breakpoint | 0.3 | 0.3 | 0.6 | 0.2 | -0.7 | 0.6 | -0.5 | -0.4 | -0.1 | -0.7 | 0.7 | -0.6 |
| Short access total infusions | 0.3 | 0.4 | 0.6 | -0.2 | 0.7 | -0.7 | 0.8 | 0.7 | 0.5 | 0.6 | -0.5 | 0.5 |
| Short access day 10 total locomotion | 0.3 | 0.3 | 1.2 | -0.5 | -0.5 | 0.5 | -0.0 | -1.1 | -1.1 | -0.2 | -0.0 | 0.0 |
| Condit. Reinf. inactive responses | 0.3 | 0.4 | 1.3 | -0.4 | -0.7 | 0.7 | -0.5 | -1.1 | -0.8 | -0.5 | 0.1 | -0.1 |
| Time in familiar zone, hab. session 2 | 0.3 | 0.3 | 0.6 | -0.8 | 0.4 | -0.4 | 0.5 | -0.3 | -0.7 | 0.6 | -0.7 | 0.7 |
| Novel to familiar place preference ratio | 0.3 | 0.3 | 0.7 | -0.1 | 0.8 | -0.6 | 0.8 | 0.7 | 0.2 | 0.7 | -0.5 | 0.5 |
| Total zone transitions, NPP test | 0.3 | 0.4 | 0.6 | 0.7 | -0.6 | 0.4 | -0.8 | -0.1 | 0.4 | -0.7 | 0.7 | -0.7 |
| Locomotion velocity, NPP test | 0.3 | 0.4 | 0.8 | -0.9 | 0.5 | -0.6 | 0.5 | -0.2 | -0.5 | 0.6 | -0.9 | 0.9 |
| Bone: cortical area | 0.3 | 0.4 | 0.7 | -0.1 | 0.8 | -0.7 | 0.9 | 0.7 | 0.2 | 0.8 | -0.6 | 0.6 |
| Bone: trabecular number | 0.3 | 0.5 | 1.7 | -0.7 | -0.4 | 0.7 | 0.3 | -1.3 | -1.1 | 0.0 | -0.0 | 0.1 |
| Distance traveled after self-admin | 0.3 | 0.4 | 0.9 | 0.2 | 0.6 | -0.9 | 0.3 | 0.7 | 1.0 | 0.3 | -0.5 | 0.4 |
| Extinction: sum of active levers before priming | 0.3 | 0.3 | 0.5 | 0.7 | -0.4 | 0.3 | -0.7 | 0.4 | 0.4 | -0.6 | 0.5 | -0.5 |
| Active lever presses in extinction session 6 | 0.3 | 0.3 | 1.0 | 0.7 | 0.1 | -0.3 | -0.4 | 1.0 | 0.8 | -0.2 | 0.4 | -0.5 |
| Time to tail flick, vehicle, after self-admin | 0.3 | 0.3 | 0.9 | -0.7 | 0.2 | -0.0 | 0.5 | -0.4 | -1.0 | 0.4 | -0.5 | 0.5 |
| Total heroin consumption | 0.3 | 0.4 | 1.3 | 0.8 | 0.2 | -0.3 | -0.3 | 1.2 | 0.9 | -0.0 | 0.6 | -0.5 |
| Delay disc. indifference point, 0s delay | 0.3 | 0.3 | 0.4 | -0.6 | 0.7 | -0.6 | 0.5 | 0.3 | -0.2 | 0.6 | -0.6 | 0.6 |
| Bouts of movement, locomotor time 1 | 0.3 | 0.3 | 0.6 | 0.6 | -0.5 | 0.3 | -0.8 | 0.0 | 0.4 | -0.8 | 0.4 | -0.6 |
| Time >=10cm from walls, locomotor time 2 | 0.3 | 0.3 | 0.9 | -1.0 | 0.2 | 0.0 | 0.5 | -0.5 | -0.7 | 0.4 | -0.5 | 0.5 |
| Locomotion in novel chamber post-restriction | 0.3 | 0.4 | 1.5 | -0.8 | -0.4 | 0.5 | 0.2 | -1.0 | -1.2 | -0.2 | -0.1 | 0.1 |
| Food seeking constrained by brief footshock | 0.3 | 0.4 | 0.9 | 0.3 | 0.7 | -0.9 | 0.3 | 0.7 | 0.6 | 0.7 | -0.5 | 0.5 |
| Cd content in liver | 0.3 | 0.3 | 0.8 | 0.3 | -0.5 | 0.8 | -0.2 | 0.1 | 0.2 | -0.4 | 0.9 | -0.9 |
| K content in liver | 0.3 | 0.3 | 1.2 | 0.7 | -0.1 | -0.3 | -0.8 | 0.6 | 1.1 | -0.4 | 0.3 | -0.3 |
| Mg content in liver | 0.3 | 0.3 | 0.9 | 0.5 | -0.5 | 0.1 | -1.0 | 0.1 | 0.7 | -0.7 | 0.6 | -0.6 |
| Rb content in liver | 0.3 | 0.4 | 0.7 | 0.3 | -0.8 | 0.7 | -0.7 | -0.4 | 0.1 | -0.7 | 0.8 | -0.8 |
| Sr content in liver | 0.3 | 0.2 | 0.6 | -0.2 | -0.5 | 0.7 | -0.2 | -0.8 | -0.7 | -0.3 | 0.2 | -0.2 |
| Epididymis fat weight | 0.2 | 0.5 | 0.9 | -0.1 | 1.0 | -0.8 | 0.6 | 1.0 | 0.6 | 0.7 | -0.6 | 0.6 |
| Tail length | 0.2 | 0.5 | 1.4 | -0.9 | 0.2 | 0.0 | 0.7 | -0.7 | -1.2 | 0.3 | -0.8 | 0.7 |
| Liver weight, left | 0.2 | 0.4 | 1.0 | 0.8 | 0.0 | -0.5 | -0.7 | 0.8 | 1.0 | -0.3 | 0.2 | -0.2 |
| Delay discounting time to switch 0 sec | 0.2 | 0.4 | 0.7 | -0.8 | 0.4 | -0.4 | 0.4 | -0.2 | -0.5 | 0.6 | -0.8 | 0.8 |
| Reaction time num false alarms | 0.2 | 0.3 | 1.0 | -0.4 | -0.3 | 0.7 | 0.5 | -1.0 | -0.9 | 0.0 | 0.1 | -0.1 |
| Social response proportion | 0.2 | 0.2 | 0.5 | 0.1 | 0.6 | -0.7 | 0.2 | 0.5 | 0.3 | 0.3 | -0.7 | 0.6 |
| Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.7 | 0.6 | -0.0 | -0.4 | -0.6 | 0.5 | 0.8 | -0.3 | 0.1 | -0.1 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.2 | 0.3 | 1.0 | 0.5 | -0.6 | 0.2 | -1.0 | -0.2 | 0.3 | -0.7 | 0.3 | -0.3 |
| Intermittent access intake day 1-15 change | 0.2 | 0.2 | 0.7 | -0.2 | -0.5 | 0.5 | -0.2 | -0.8 | -0.8 | -0.3 | 0.2 | -0.2 |
| Intermittent access day 1 total infusions | 0.2 | 0.3 | 1.0 | 0.6 | 0.4 | -0.4 | 0.3 | 0.8 | 1.0 | 0.1 | -0.0 | 0.0 |
| Intermittent access total infusions | 0.2 | 0.2 | 0.5 | -0.1 | 0.6 | -0.4 | 0.7 | 0.5 | 0.4 | 0.5 | -0.5 | 0.5 |
| Intermittent access day 1 locomotion | 0.2 | 0.2 | 0.5 | -0.4 | 0.5 | -0.3 | 0.7 | -0.1 | -0.2 | 0.6 | -0.6 | 0.6 |
| Short access total locomotion | 0.2 | 0.2 | 0.3 | -0.5 | 0.2 | -0.2 | 0.5 | -0.4 | -0.4 | 0.3 | -0.5 | 0.5 |
| Time in novel zone, hab. session 2 | 0.2 | 0.2 | 0.4 | 0.7 | -0.3 | 0.3 | -0.2 | 0.2 | 0.6 | -0.4 | 0.6 | -0.6 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.3 | 0.7 | -0.3 | 0.6 | -0.8 | 0.3 | 0.4 | 0.3 | 0.5 | -0.6 | 0.6 |
| Bone: apparent density | 0.2 | 0.3 | 0.8 | 0.1 | -0.7 | 0.6 | -0.5 | -0.9 | -0.3 | -0.5 | 0.4 | -0.4 |
| Bone: tissue strength | 0.2 | 0.2 | 0.6 | 0.8 | 0.1 | -0.2 | -0.3 | 0.7 | 0.7 | -0.2 | 0.3 | -0.4 |
| Breakpoint value in progressive ratio session | 0.2 | 0.3 | 0.5 | -0.4 | 0.6 | -0.6 | 0.3 | 0.3 | 0.1 | 0.6 | -0.7 | 0.7 |
| Time in closed arm after self-admin | 0.2 | 0.2 | 0.5 | -0.1 | -0.5 | 0.5 | -0.4 | -0.7 | -0.4 | -0.3 | 0.3 | -0.3 |
| Sum of active levers in priming session hrs 5-6 | 0.2 | 0.2 | 0.4 | -0.0 | 0.5 | -0.6 | 0.2 | 0.6 | 0.3 | 0.4 | -0.5 | 0.4 |
| Delta time to tail flick, vehicle, before/after SA | 0.2 | 0.2 | 0.5 | 0.4 | 0.0 | -0.1 | -0.3 | 0.6 | 0.7 | -0.0 | 0.4 | -0.3 |
| Time >=10cm from walls, locomotor time 1 | 0.2 | 0.2 | 0.6 | -0.3 | 0.6 | -0.5 | 0.3 | 0.5 | 0.4 | 0.8 | -0.4 | 0.5 |
| Latency to leave start box in cocaine runway, F | 0.2 | 0.2 | 0.5 | 0.5 | 0.4 | -0.7 | 0.0 | 0.6 | 0.7 | 0.2 | -0.4 | 0.3 |
| Fe content in liver | 0.2 | 0.2 | 0.4 | -0.4 | 0.5 | -0.6 | 0.5 | 0.1 | 0.2 | 0.5 | -0.7 | 0.6 |
| Heart weight | 0.1 | 0.2 | 0.4 | 0.7 | 0.1 | -0.1 | -0.1 | 0.6 | 0.6 | 0.0 | 0.4 | -0.4 |
| Liver weight, right | 0.1 | 0.2 | 0.3 | -0.5 | 0.4 | -0.4 | 0.5 | 0.1 | -0.2 | 0.4 | -0.6 | 0.5 |
| Intraocular pressure | 0.1 | 0.1 | 0.4 | -0.4 | 0.3 | -0.1 | 0.7 | 0.1 | -0.4 | 0.4 | -0.2 | 0.2 |
| Tibia length | 0.1 | 0.3 | 1.0 | 0.4 | 0.6 | -0.6 | 0.4 | 1.0 | 0.7 | 0.5 | -0.1 | 0.1 |
| Delay discounting total patch changes 0 sec | 0.1 | 0.1 | 0.4 | -0.1 | -0.4 | 0.5 | -0.1 | -0.6 | -0.3 | -0.3 | 0.1 | -0.1 |
| Delay discounting water rate 0 sec | 0.1 | 0.2 | 0.5 | 0.1 | 0.5 | -0.4 | 0.6 | 0.7 | 0.4 | 0.4 | -0.2 | 0.2 |
| Delay discounting water rate 6 sec | 0.1 | 0.2 | 0.6 | -0.6 | -0.1 | 0.1 | 0.3 | -0.6 | -0.8 | 0.2 | -0.2 | 0.2 |
| Reaction time mean minus median | 0.1 | 0.1 | 0.2 | 0.3 | -0.2 | 0.4 | 0.0 | 0.1 | 0.3 | -0.2 | 0.5 | -0.4 |
| Reaction time mean minus median AUC | 0.1 | 0.2 | 0.6 | 0.1 | 0.5 | -0.3 | 0.6 | 0.8 | 0.3 | 0.4 | -0.1 | 0.1 |
| Reaction time num false alarms AUC | 0.1 | 0.1 | 0.5 | -0.1 | -0.3 | 0.5 | 0.3 | -0.7 | -0.6 | -0.0 | 0.2 | -0.2 |
| Std. dev. reaction times | 0.1 | 0.1 | 0.3 | 0.3 | -0.4 | 0.5 | -0.2 | 0.0 | 0.3 | -0.2 | 0.6 | -0.5 |
| Social responses | 0.1 | 0.1 | 0.3 | -0.2 | 0.3 | -0.5 | 0.2 | 0.2 | -0.1 | 0.3 | -0.6 | 0.5 |
| Cocaine response before conditioning | 0.1 | 0.1 | 0.3 | -0.1 | -0.3 | 0.4 | 0.0 | -0.5 | -0.4 | -0.2 | 0.2 | -0.2 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.5 | 0.3 | 0.2 | -0.4 | -0.2 | 0.7 | 0.5 | -0.1 | -0.2 | 0.1 |
| Pavlov. Cond. lever latency | 0.1 | 0.1 | 0.3 | -0.3 | -0.1 | 0.4 | 0.3 | -0.4 | -0.5 | 0.1 | 0.1 | -0.1 |
| Conditioned reinforcement - inactives | 0.1 | 0.1 | 0.3 | 0.4 | -0.3 | -0.1 | -0.4 | 0.2 | 0.5 | -0.5 | 0.3 | -0.4 |
| Intermitt. access escalation Index | 0.1 | 0.0 | 0.1 | -0.4 | 0.2 | -0.0 | 0.1 | -0.1 | -0.0 | 0.3 | -0.3 | 0.3 |
| Intermittent access day 15 total infusions | 0.1 | 0.1 | 0.4 | -0.1 | 0.4 | -0.3 | 0.6 | 0.2 | 0.1 | 0.4 | -0.4 | 0.4 |
| Intermittent access terminal intake (last 3 days) | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | -0.5 | 0.3 | 0.4 | 0.5 | 0.2 | -0.2 | 0.2 |
| Progressive ratio test 1 active lever presses | 0.1 | 0.1 | 0.2 | 0.1 | -0.5 | 0.4 | -0.3 | -0.2 | 0.0 | -0.4 | 0.5 | -0.4 |
| Progressive ratio test 1 inactive lever presses | 0.1 | 0.1 | 0.2 | 0.3 | 0.0 | -0.2 | -0.3 | 0.4 | 0.5 | -0.2 | 0.2 | -0.2 |
| Short access day 10 total infusions | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | 0.5 | 0.3 | -0.4 | -0.4 | -0.2 | 0.0 | -0.1 |
| Short access day 1 locomotion | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | -0.5 | 0.4 | -0.2 | 0.0 | 0.4 | -0.5 | 0.5 |
| One hour access (0.3 mA shock) | 0.1 | 0.1 | 0.3 | -0.3 | 0.2 | -0.0 | 0.6 | 0.0 | 0.0 | 0.4 | -0.3 | 0.3 |
| Locomotion distance, session 1 | 0.1 | 0.2 | 0.3 | 0.5 | -0.4 | 0.2 | -0.5 | -0.1 | 0.3 | -0.5 | 0.5 | -0.5 |
| Locomotion distance, session 7 | 0.1 | 0.1 | 0.1 | -0.1 | -0.3 | 0.3 | -0.3 | -0.3 | -0.3 | -0.3 | 0.1 | -0.1 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.2 | -0.1 | 0.4 | 0.3 | -0.4 | -0.5 | 0.1 | 0.1 | -0.1 |
| Locomotion velocity, hab. session 2 | 0.1 | 0.1 | 0.4 | -0.1 | 0.4 | -0.6 | 0.1 | 0.3 | 0.4 | 0.3 | -0.4 | 0.4 |
| Bone: connectivity density | 0.1 | 0.1 | 0.5 | -0.1 | -0.4 | 0.4 | -0.2 | -0.7 | -0.3 | -0.2 | 0.2 | -0.1 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.2 | -0.2 | 0.4 | -0.4 | 0.4 | 0.3 | -0.1 | 0.4 | -0.5 | 0.4 |
| Bone: trabecular thickness | 0.1 | 0.1 | 0.5 | -0.2 | -0.2 | 0.1 | -0.2 | -0.7 | -0.3 | -0.1 | -0.1 | 0.1 |
| Time in open arm before self-admin | 0.1 | 0.1 | 0.1 | -0.3 | -0.2 | 0.4 | 0.0 | -0.2 | -0.2 | -0.3 | 0.2 | -0.2 |
| Time to tail flick, vehicle, before self-admin | 0.1 | 0.1 | 0.4 | 0.6 | 0.1 | -0.4 | -0.2 | 0.5 | 0.3 | 0.0 | -0.0 | 0.0 |
| Time to tail flick, test, before self-admin | 0.1 | 0.1 | 0.2 | -0.4 | 0.3 | -0.4 | 0.4 | -0.0 | -0.3 | 0.5 | -0.4 | 0.4 |
| Ambulatory time after self-admin | 0.1 | 0.1 | 0.7 | 0.2 | 0.2 | -0.5 | 0.1 | 0.4 | 0.8 | -0.0 | -0.2 | 0.1 |
| Rest time, locomotor task time 1 | 0.1 | 0.1 | 0.3 | -0.0 | 0.3 | -0.5 | 0.0 | 0.6 | 0.3 | 0.1 | -0.2 | 0.2 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.2 | 0.1 | -0.4 | 0.3 | -0.4 | -0.2 | 0.3 | -0.1 | 0.4 | -0.4 |
| Rest time, locomotor task time 2 | 0.1 | 0.2 | 0.3 | 0.1 | -0.5 | 0.5 | -0.5 | -0.4 | -0.2 | -0.5 | 0.3 | -0.3 |
| Se content in liver | 0.1 | 0.1 | 0.4 | -0.5 | -0.1 | 0.0 | -0.1 | -0.6 | -0.3 | 0.1 | -0.0 | 0.1 |
| Length with tail | 0.0 | 0.1 | 0.4 | -0.2 | 0.4 | -0.3 | 0.6 | 0.1 | -0.2 | 0.4 | -0.4 | 0.4 |
| Parametrial fat weight | 0.0 | 0.1 | 0.5 | 0.3 | -0.2 | -0.0 | -0.7 | -0.2 | 0.4 | -0.2 | 0.1 | -0.1 |
| Tibialis anterior weight | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | -0.1 | -0.3 | -0.2 | -0.0 | -0.1 | -0.2 | 0.1 |
| Indifference point 0 sec | 0.0 | 0.1 | 0.2 | 0.1 | -0.4 | 0.4 | -0.2 | -0.4 | 0.0 | -0.3 | 0.1 | -0.1 |
| Delay discounting water rate 18 sec | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | -0.1 | 0.1 | -0.1 | -0.1 | 0.0 | 0.0 | -0.0 |
| Locomotor testing distance | 0.0 | 0.0 | 0.1 | -0.2 | 0.0 | -0.1 | 0.2 | -0.2 | -0.3 | 0.2 | 0.0 | 0.0 |
| Reaction time false alarm rate | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.3 | -0.2 | -0.0 | 0.2 | -0.0 | 0.0 |
| Pavlov. Cond. intertrial magazine entries | 0.0 | 0.1 | 0.2 | 0.1 | -0.3 | 0.2 | -0.3 | -0.4 | -0.1 | -0.2 | 0.1 | -0.1 |
| Bone surface | 0.0 | 0.1 | 0.1 | 0.3 | -0.4 | 0.2 | -0.3 | -0.3 | 0.1 | -0.2 | 0.3 | -0.3 |
| Bone volume | 0.0 | 0.0 | 0.2 | 0.1 | -0.3 | 0.1 | -0.2 | -0.5 | -0.0 | -0.1 | 0.1 | -0.1 |
| Fecal boli incidents, locomotor time 1 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.3 | -0.1 | 0.3 | 0.4 | -0.1 | 0.0 | 0.0 |
| Distance moved, locomotor task time 1 | 0.0 | 0.0 | 0.1 | -0.0 | 0.1 | -0.1 | 0.0 | 0.0 | 0.3 | 0.3 | 0.1 | 0.0 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.