Hub : Genes

Tle5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	ENSRNOT00000113477	0.04	0.03	7.2e-03	0.02	0.01	0.01	0.01	4.1e-03	1.6e-02	2.0e-02	2.0e-02
2	Adipose	intron excision ratio	chr7:8144252:8144373	0.03	0.02	5.6e-03	0.01	0.01	0.01	0.01	6.7e-03	2.2e-02	1.6e-02	3.4e-02
3	Brain	mRNA stability	ENSRNOG00000052025	0.03	0.03	7.2e-03	0.02	0.02	0.01	0.01	6.6e-03	1.0e-02	2.0e-02	1.9e-02
4	Liver	intron excision ratio	chr7:8144249:8144373	0.03	0.02	6.0e-03	0.02	0.01	0.02	0.02	1.8e-03	2.0e-02	5.0e-03	5.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	5.0	16.0	21.5	-0.8	4.6	-4.6	-4.6
BMI without tail	2.1	4.5	7.2	-1.0	2.7	-2.0	-2.4
Body weight	0.9	3.8	5.4	-0.6	2.2	-2.2	-2.3
Epididymis fat weight	0.1	0.3	0.5	-0.7	-0.2	0.7	0.2
Glucose	0.9	1.4	1.9	-0.4	1.4	-1.3	-1.4
Heart weight	0.3	0.4	0.8	-0.7	-0.2	0.9	0.5
Left kidney weight	0.2	0.7	1.7	1.3	-0.6	0.1	0.8
Right kidney weight	1.2	3.5	5.1	0.8	-2.1	2.0	2.3
Tail length	2.1	6.5	10.8	-0.5	-2.7	3.3	2.7
Length with tail	1.5	5.5	8.2	0.4	-2.9	2.6	2.6
Length without tail	0.3	0.7	1.1	1.0	-1.1	0.0	0.7
Liver weight, left	2.2	3.6	5.4	-0.8	2.3	-1.9	-2.1
Liver weight, right	1.2	2.0	3.0	-0.1	1.6	-1.7	-1.6
Parametrial fat weight	0.3	0.6	1.0	-0.4	-0.9	1.0	0.8
Retroperitoneal fat weight	0.5	1.5	2.4	-1.0	1.2	-1.1	-1.6
Intraocular pressure	0.5	0.7	2.1	-1.4	0.6	0.5	-0.5
Extensor digitorum longus weight	3.9	15.8	22.1	-2.1	4.6	-3.9	-4.7
Soleus weight	6.6	19.1	26.9	-0.8	5.0	-5.2	-4.9
Tibialis anterior weight	0.7	2.3	3.3	-0.2	1.7	-1.8	-1.7
Tibia length	0.6	1.7	2.8	-0.2	-1.5	1.7	1.4
Number of licking bursts	0.6	0.7	1.9	-1.4	0.6	0.0	-0.8
Food consumed during 24 hour testing period	0.4	0.4	0.6	-0.2	0.8	-0.7	-0.8
Times rat made contact with spout	0.4	0.5	0.8	-0.9	0.8	-0.2	-0.8
Mean time between licks in bursts	2.7	3.8	6.3	-0.5	-2.1	2.5	2.1
Mean num. licks in bursts	0.1	0.1	0.3	0.5	-0.0	-0.1	0.1
Std. dev. time between licks in bursts	1.2	1.5	2.0	1.2	-1.4	0.7	1.3
Water consumed over 24 hours	0.5	0.6	1.1	1.1	0.3	-1.0	-0.3
Indifference point 0 sec	0.1	0.2	0.3	0.1	0.3	-0.6	-0.5
Indifference point AUC	0.7	0.8	1.4	0.0	-0.9	1.2	1.1
Indifference point function ln k	0.2	0.3	0.5	-0.3	0.5	-0.6	-0.7
Indifference point function log k	0.2	0.3	0.5	-0.3	0.5	-0.6	-0.7
Delay discounting total patch changes 0 sec	0.1	0.1	0.3	-0.1	0.3	-0.5	-0.5
Delay discounting total patch changes 12 sec	0.6	0.7	1.1	-0.9	1.1	-0.4	-1.0
Delay discounting total patch changes 18 sec	0.7	0.9	1.3	0.1	-1.1	1.2	1.1
Delay discounting total patch changes 24 sec	0.1	0.1	0.2	0.3	-0.3	0.3	0.4
Delay discounting total patch changes 6 sec	0.1	0.2	0.4	-0.1	-0.6	0.4	0.3
Delay discounting time to switch 0 sec	1.0	1.6	3.2	1.0	1.0	-1.8	-1.1
Delay discounting water rate 0 sec	0.4	0.7	2.1	-1.5	0.4	0.5	-0.5
Delay discounting water rate 12 sec	1.6	2.4	3.3	-1.6	1.8	-0.8	-1.7
Delay discounting water rate 18 sec	1.6	2.1	6.5	-2.5	0.9	0.8	-0.8
Delay discounting water rate 24 sec	2.9	4.0	9.8	-3.1	1.6	0.1	-1.9
Delay discounting water rate 6 sec	0.8	1.2	3.3	-1.8	0.0	1.1	-0.1
Locomotor activity	3.5	5.6	8.7	1.4	-2.9	2.0	2.7
Locomotor testing distance	1.9	3.2	4.8	0.9	-2.2	1.6	2.1
Locomotor testing rearing	0.0	0.0	0.1	-0.3	0.0	0.2	0.1
Light reinforcement 1	4.4	8.0	11.5	0.5	-3.4	3.2	3.1
Light reinforcement 2	1.4	1.8	2.9	0.2	-1.7	1.5	1.5
Reaction time number correct	1.1	1.5	2.0	-1.3	1.4	-0.6	-1.4
Reaction time mean minus median	0.7	0.9	1.5	0.5	-1.0	1.0	1.2
Reaction time mean minus median AUC	0.9	1.1	3.0	1.7	-0.8	-0.2	0.9
Reaction time num false alarms	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.3
Reaction time num false alarms AUC	0.3	0.4	0.7	-0.8	0.7	-0.1	-0.6
Reaction time trials correct on left	1.1	1.5	2.0	-1.3	1.4	-0.6	-1.4
Reaction time trials on left	1.0	1.4	1.9	-1.2	1.4	-0.6	-1.3
Reaction time mean	0.4	0.6	1.7	1.3	-0.4	-0.3	0.6
Reaction time mean AUC	0.4	0.5	1.6	1.2	-0.4	-0.4	0.5
Median of all reaction times	0.4	0.6	1.5	1.2	0.1	-0.9	0.0
Reaction time omissions	0.3	0.4	0.6	0.5	-0.8	0.5	0.7
Reaction time false alarm rate	0.0	0.0	0.0	0.2	0.0	-0.1	0.1
Reaction time premature initiation rate	0.7	0.9	1.7	-1.0	-0.8	1.3	0.5
Reaction time premature initiations	0.8	1.1	3.2	-1.8	-0.1	1.1	-0.1
Std. dev. reaction times	0.5	0.7	1.0	1.0	-0.8	0.4	1.0
Reaction time trials completed	1.0	1.4	1.9	-1.2	1.4	-0.6	-1.3
Reaction time trials AUC	1.1	1.6	2.2	-1.5	1.4	-0.5	-1.4
Social response proportion	0.6	0.7	1.1	0.6	-0.8	0.7	1.1
Social responses	6.8	8.8	13.2	1.5	-3.3	2.9	3.6
Social time	0.6	0.8	1.2	-0.5	1.0	-0.9	-1.1
Conditioned locomotion	2.5	2.9	4.0	-1.6	2.0	-1.1	-2.0
Cocaine response after cond. corrected	5.5	6.1	8.7	-1.8	2.9	-2.1	-2.9
Cocaine response after cond. not corrected	6.0	6.7	9.4	-1.9	3.0	-2.1	-3.1
Cocaine response before conditioning	0.5	0.6	0.9	0.6	-0.9	0.7	1.0
Saline control response	0.1	0.2	0.2	-0.5	0.4	-0.1	-0.5
Condit. Reinf. active minus inactive responses	1.5	1.9	3.7	-0.8	-1.2	1.9	1.2
Condit. Reinf. active-inactive response ratio	0.8	0.8	2.6	-1.6	0.4	0.7	-0.4
Condit. Reinf. active responses	1.7	2.3	3.6	0.0	-1.7	1.9	1.7
Condit. Reinf. inactive responses	1.3	1.6	2.4	0.9	-1.5	1.1	1.5
Condit. Reinf. lever presses	1.5	2.1	4.0	-0.6	-1.4	2.0	1.4
Condit. Reinf. lever reinforcers received	1.2	1.7	3.0	-0.3	-1.3	1.7	1.3
Pavlov. Cond. lever latency	0.7	1.0	1.4	-0.3	1.1	-1.1	-1.2
Pavlov. Cond. magazine entry latency	0.6	0.7	1.1	0.6	-1.0	0.7	1.0
Pavlov. Cond. change in total contacts	0.7	0.9	1.4	-0.0	-1.0	1.2	1.1
Pavlov. Cond. index score	0.8	1.0	1.5	0.2	-1.1	1.1	1.2
Pavlov. Cond. latency score	0.8	1.1	1.5	0.5	-1.2	1.0	1.2
Pavlov. Cond. lever contacts	0.6	0.8	1.3	-0.1	-0.9	1.2	1.0
Pavlov. Cond. magazine entry number	0.9	1.2	1.7	-0.6	1.3	-1.0	-1.3
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	-0.9	0.9	-0.6	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.6	0.4	-1.2	1.1	1.3
Pavlov. Cond. response bias	1.3	1.9	3.0	-0.1	-1.4	1.7	1.5
Conditioned reinforcement - actives	2.1	2.1	2.8	0.5	-1.6	1.6	1.7
Conditioned reinforcement - inactives	1.0	1.2	1.7	-1.3	1.0	-0.6	-1.3
Conditioned locomotion	5.9	7.1	10.3	0.3	-3.0	3.2	3.0
Intermittent access intake day 1-15 change	4.7	4.7	7.6	-0.3	-2.5	2.8	2.3
Intermittent access intake escalation	4.3	4.2	8.1	-1.3	-2.0	2.8	1.7
Intermittent access intake escalation 2	5.1	5.1	9.9	-1.1	-2.2	3.1	2.1
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.8	-0.9	-0.3	0.9	0.2
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.5	-0.6	-0.5	0.7	0.4
Intermitt. access escalation Index	0.7	0.6	2.0	1.4	-0.1	-0.7	0.3
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.1	0.1	-0.4	-0.1
Intermittent access day 15 total infusions	1.2	1.3	2.3	-0.7	-1.2	1.5	1.1
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.4	0.1	-1.0	1.1	1.2
Intermittent access total infusions	0.1	0.1	0.2	-0.4	-0.4	0.4	0.3
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.4	-0.5	0.5	0.4
Intermittent access day 15 total locomotion	2.5	2.6	4.1	-0.5	-1.8	2.0	1.7
Intermittent access total locomotion	0.8	0.9	1.3	-0.1	-1.2	1.1	1.1
Intermittent access standard deviation	2.1	2.3	4.0	-0.4	-1.5	2.0	1.6
Cocaine induced anxiety	1.3	1.5	2.0	1.4	-1.2	0.7	1.4
Post-drug Anxiety	1.4	1.6	3.7	1.9	-1.0	0.3	1.3
Baseline Anxiety	0.1	0.1	0.3	-0.6	0.1	0.2	-0.2
Lifetime Intake	0.0	0.1	0.1	-0.0	-0.3	0.2	0.3
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.4	-0.2	0.7	0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	-0.1	-0.3	0.8	0.5
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.5	0.5	-0.3	-0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.4	0.6	-0.4	-0.4
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.0	-0.1	0.0	0.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	-0.5	-0.2	0.6	0.3
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	0.1	-0.5	0.6	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.2	-0.3	0.2	0.3
Total sessions with >9 infusions	0.4	0.4	1.2	1.1	-0.3	-0.2	0.7
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.0	-0.1	0.2	0.2
Short access day 10 total inactive lever presses	0.2	0.2	0.7	-0.8	0.0	0.4	-0.1
Short access day 1 total infusions	0.6	0.6	1.3	1.1	-0.6	0.0	0.9
Short access day 10 total infusions	0.0	0.0	0.0	0.1	0.0	0.0	0.1
Short access total infusions	0.2	0.2	0.6	0.8	-0.1	-0.1	0.5
Short access day 1 locomotion	1.0	1.1	1.9	0.5	-1.4	0.7	1.2
Short access day 10 total locomotion	2.9	3.1	5.3	-0.5	-2.0	2.3	1.8
Short access total locomotion	0.9	0.9	1.5	0.3	-1.1	0.9	1.2
Compulsive drug intake	0.6	0.6	1.0	0.2	0.7	-1.0	-0.9
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.3	0.4	-0.5	-0.5
One hour access (shock baseline)	0.1	0.2	0.6	-0.7	-0.0	0.2	-0.1
Number of responses in last shaping day	0.2	0.2	0.3	0.2	-0.5	0.4	0.5
Context. condit. distance diff. score	0.3	0.3	0.4	-0.2	0.6	-0.6	-0.6
Locomotion velocity, session 1	1.3	1.4	2.0	1.4	-1.3	0.6	1.3
Locomotion distance, session 1	1.0	1.3	3.4	1.8	-0.9	-0.1	0.9
Locomotion velocity, session 2	4.5	5.3	7.1	2.1	-2.7	1.6	2.6
Locomotion distance, session 2	2.4	3.5	4.6	2.1	-2.1	1.0	2.0
Locomotion velocity, session 3	4.4	5.1	7.5	0.2	-2.5	2.7	2.6
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.0	0.2	0.0
Stereotopy head waving bouts, day 3	3.8	4.6	6.4	1.0	-2.5	2.2	2.5
Stereotopy head waving duration, day 3	4.2	5.1	7.0	0.8	-2.6	2.5	2.6
Locomotion velocity, session 7	0.8	0.8	1.2	0.6	-1.1	0.8	1.0
Locomotion distance, session 7	0.3	0.3	0.8	-0.9	0.5	-0.0	-0.5
Stereotopy head waving bouts, day 7	0.6	0.7	2.0	1.4	-0.6	-0.3	0.6
Stereotopy head waving duration, day 7	1.0	1.2	2.7	1.7	-1.0	0.0	1.0
Locomotion velocity, session 8	1.7	2.0	4.1	2.0	-1.4	0.2	1.4
Locomotion distance, session 8	0.2	0.3	0.5	0.7	-0.5	0.2	0.5
Degree of sensitization distance	0.3	0.3	0.4	-0.0	0.5	-0.7	-0.6
Degree of sensitization stereotypy	1.2	1.3	2.6	1.0	0.8	-1.6	-0.9
Condit. Reinf. active minus inactive responses	3.2	3.5	4.8	0.4	-2.2	2.1	2.1
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.8	-0.5	-1.3	1.7	1.2
Condit. Reinf. active responses	3.4	4.1	5.9	1.3	-2.4	1.9	2.3
Condit. Reinf. inactive responses	1.4	1.6	2.3	1.5	-1.4	0.6	1.3
Incentive salience index mean	2.2	2.7	3.9	1.1	-2.0	1.4	1.9
Condit. Reinf. lever presses	1.1	1.5	4.1	2.0	-1.0	-0.3	0.9
Time in familiar zone, hab. session 1	1.4	1.3	2.4	-0.3	-1.2	1.5	1.2
Time in novel zone, hab. session 1	0.8	0.8	1.5	1.2	0.4	-1.2	-0.5
Total zone transitions, hab. session 1	1.4	2.0	2.6	1.6	-1.5	0.8	1.6
Total locomotion distance, hab. session 1	2.6	3.7	6.4	2.5	-2.0	0.7	2.0
Locomotion velocity, hab. session 1	2.4	3.4	4.3	2.1	-2.0	1.0	2.1
Time in familiar zone, hab. session 2	4.1	4.3	7.9	-0.8	-2.1	2.8	2.1
Time in novel zone, hab. session 2	3.0	3.0	5.9	1.0	1.6	-2.4	-1.6
Total zone transitions, hab. session 2	0.8	1.0	3.3	1.8	-0.3	-0.8	0.2
Total locomotion distance, hab. session 2	1.2	1.7	2.1	1.4	-1.4	0.8	1.4
Locomotion velocity, hab. session 2	1.5	2.0	3.2	1.8	-1.5	0.7	1.5
Novel to familiar place preference ratio	2.4	2.6	5.2	1.3	1.3	-2.3	-1.3
Novelty place preference	1.5	1.6	3.2	1.3	0.9	-1.8	-0.9
Time in novel zone, NPP test	1.7	1.7	3.5	1.2	1.0	-1.9	-1.0
Total zone transitions, NPP test	0.2	0.3	0.9	0.9	-0.2	-0.3	0.2
Total locomotion distance, NPP test	0.4	0.6	1.9	1.4	-0.3	-0.4	0.3
Locomotion velocity, NPP test	0.4	0.6	1.8	1.3	-0.6	-0.1	0.6
Pavlov. Cond. lever latency	0.5	0.6	1.8	-1.3	0.5	0.3	-0.5
Pavlov. Cond. magazine entry latency	1.8	2.3	3.7	-0.1	-1.7	1.9	1.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	-0.3	0.2	0.3
Pavlov. Cond. index score	0.6	0.7	0.9	0.9	-1.0	0.5	0.9
Pavlov. Cond. latency score	0.8	1.0	1.7	1.3	-1.1	0.4	1.1
Pavlov. Cond. lever contacts	0.8	1.0	2.6	1.6	-0.8	-0.1	0.8
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	-0.1	0.8	-0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.9	-1.0	0.2	0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.4	0.9	-1.2	0.8	1.2
Pavlov. Cond. response bias	0.8	0.9	1.3	0.3	-1.1	1.1	1.1
Bone: apparent density	1.5	2.5	7.0	2.6	-1.1	-0.5	1.2
Bone surface	3.5	6.2	15.1	3.9	-2.2	-0.2	2.2
Bone volume	3.6	6.1	15.1	3.9	-2.2	-0.2	2.2
Bone: connectivity density	0.8	1.3	3.9	2.0	-0.5	-0.8	0.5
Bone: cortical apparent density	0.7	1.0	1.5	-0.2	1.1	-1.2	-1.1
Bone: cortical area	0.6	0.9	2.0	1.4	0.2	-1.2	-0.1
Bone: cortical porosity	0.7	0.7	1.0	0.8	-1.0	0.6	1.0
Bone: cortical porosity	0.5	0.5	1.3	1.2	-0.6	-0.1	0.6
Bone: cortical thickness	0.7	1.2	2.4	0.6	1.0	-1.6	-1.0
Bone: cortical thickness	0.2	0.2	0.7	-0.8	0.3	0.2	-0.3
Bone: cortical tissue density	0.5	0.7	1.1	-0.2	0.9	-1.0	-0.9
Bone: elastic displacement	0.3	0.3	0.4	0.2	-0.6	0.5	0.6
Bone: elastic work	0.1	0.2	0.3	0.6	0.1	-0.6	-0.1
Bone: endosteal estimation	0.2	0.3	0.7	0.8	0.2	-0.8	-0.2
Bone: endosteal perimeter	0.6	1.3	2.0	1.4	-1.2	0.4	1.2
Bone: final force	0.8	1.3	2.6	1.2	0.7	-1.6	-0.7
Bone: final moment	0.6	1.0	2.2	1.1	0.6	-1.5	-0.6
Bone: marrow area	0.2	0.3	0.7	0.7	0.2	-0.9	-0.2
Bone: maximum diameter	1.3	2.3	3.1	1.8	-1.7	0.7	1.7
Bone: maximum force	0.8	1.3	2.9	0.9	0.9	-1.7	-0.9
Bone: maximum moment	0.6	1.1	2.4	0.9	0.8	-1.6	-0.8
Bone: minimum diameter	0.2	0.4	1.3	1.1	-0.4	-0.4	0.4
Bone: periosteal estimation	0.5	1.0	2.5	1.6	0.0	-1.2	-0.0
Bone: periosteal perimeter	0.7	1.2	2.9	1.7	-1.0	-0.1	1.0
Bone: post-yield work	0.5	0.7	1.0	-0.1	0.9	-1.0	-0.9
Bone: stiffness	1.9	3.1	5.7	0.5	1.8	-2.4	-1.8
Bone: tissue strength	1.2	1.2	2.2	0.2	1.1	-1.5	-1.1
Bone: trabecular number	1.7	2.6	3.6	1.9	-1.8	0.7	1.8
Bone: trabecular spacing	2.5	3.2	6.8	-2.6	1.7	-0.1	-1.7
Bone: trabecular thickness	3.6	4.3	11.9	3.5	-1.6	-0.6	1.6
Bone: trabecular tissue density	2.5	3.5	4.8	-1.4	2.2	-1.6	-2.2
Breakpoint value in progressive ratio session	3.5	3.9	7.0	-0.4	-2.0	2.6	2.1
Distance traveled before self-admin	0.2	0.2	0.3	0.4	0.4	-0.5	-0.3
Distance traveled after self-admin	0.6	0.7	1.1	0.4	-0.9	0.8	1.1
Delta time in closed arm before/after self-admin	2.5	2.5	4.9	-2.2	1.6	-0.3	-1.5
Delta time in open arm before/after self-admin	0.8	0.8	1.4	0.2	0.8	-1.2	-1.0
Diff in mean of infusions in LGA sessions	1.0	1.1	1.7	0.0	-1.0	1.3	1.3
Extinction: sum of active levers before priming	1.0	1.0	2.1	-1.1	-0.6	1.5	0.6
Active lever presses in extinction session 6	2.3	2.2	3.5	0.5	-1.5	1.7	1.9
Delta distance traveled before/after self-admin	1.0	1.1	1.6	0.2	-1.2	1.2	1.3
Delta ambulatory time before/after self-admin	1.4	1.5	2.4	0.7	-1.3	1.1	1.6
Time in closed arm before self-admin	0.7	0.8	1.5	1.1	0.3	-1.2	-0.5
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0
Time in open arm before self-admin	0.7	0.8	1.5	-0.3	-0.8	1.2	0.9
Time in open arm after self-admin	0.6	0.6	1.0	-0.5	0.8	-0.7	-1.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.2	0.1	0.0	-0.1
Time to tail flick, vehicle, before self-admin	1.5	1.6	2.7	1.7	-1.2	0.5	1.4
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.9	-0.9	0.3	0.5	-0.2
Time to tail flick, test, before self-admin	1.1	1.1	2.6	1.6	-0.7	0.1	1.0
Time to tail flick, test, after self-admin	0.6	0.6	1.1	1.1	-0.6	0.3	0.9
Delta time to tail flick, vehicle, before/after SA	1.7	1.7	3.1	-1.8	1.3	-0.3	-1.4
Delta time to tail flick, test, before/after SA	0.3	0.3	0.9	-1.0	0.0	0.5	-0.1
Ambulatory time before self-admin	0.1	0.1	0.2	0.1	0.4	-0.5	-0.3
Ambulatory time after self-admin	0.4	0.4	0.6	0.3	-0.7	0.6	0.8
Total heroin consumption	1.6	1.9	2.9	0.6	-1.4	1.5	1.7
Area under the delay curve	1.4	1.5	2.6	0.4	1.2	-1.6	-1.3
Delay disc. indifference point, 0s delay	4.8	5.2	10.1	1.6	1.9	-3.2	-2.0
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.2	0.3	-0.4	-0.3
Delay disc. indifference point, 2s delay	3.7	4.2	7.6	0.8	2.0	-2.8	-2.1
Delay disc. indifference point, 24s delay	0.4	0.4	0.6	0.1	0.8	-0.7	-0.7
Delay disc. indifference point, 4s delay	0.8	0.9	1.6	1.1	0.6	-1.3	-0.6
Delay disc. indifference point, 8s delay	1.0	1.1	1.5	-0.7	1.2	-0.9	-1.2
Delay discount exponential model param	1.3	1.3	2.3	-0.4	-1.2	1.5	1.2
Delay discount hyperbolic model param	1.8	1.9	3.3	-0.4	-1.4	1.8	1.5
Fecal boli incidents, locomotor time 1	2.1	2.2	3.0	-1.2	1.7	-1.2	-1.7
Change in fecal boli incidents, locomotor task	1.2	1.1	2.2	1.5	-1.0	0.3	1.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.1	1.0	0.1	-0.8	-0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.2	-0.3	0.4	0.4
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.1	-0.5	0.5	0.6
Rest time, locomotor task time 1	0.2	0.2	0.3	0.5	-0.5	0.3	0.6
Distance moved, locomotor task time 1	0.4	0.4	1.1	1.0	0.1	-0.8	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.4
Time >=10cm from walls, locomotor time 2	1.1	1.2	1.7	-0.7	1.2	-1.0	-1.3
Bouts of movement, locomotor time 2	0.8	0.9	1.4	1.2	-1.0	0.4	1.0
Total resting periods, locomotor time 2	0.9	1.0	1.8	1.3	-1.0	0.3	1.0
Rest time, locomotor task time 2	0.8	0.9	1.2	1.0	-1.0	0.6	1.1
Distance moved, locomotor task time 2	1.0	1.1	1.6	-1.0	1.1	-0.8	-1.3
Vertical activity count, locomotor time 2	1.4	1.6	2.2	-1.5	1.3	-0.6	-1.4
Weight adjusted by age	0.6	0.6	1.4	-0.7	1.2	-0.4	-0.8
Seeking ratio, delayed vs. immediate footshock	4.5	5.1	7.7	0.9	-2.8	2.3	2.5
Locomotion in novel chamber	0.2	0.3	0.8	-0.1	-0.2	0.9	0.5
Locomotion in novel chamber post-restriction	0.5	0.6	0.8	0.3	-0.7	0.9	0.9
Progressive ratio	0.3	0.4	0.6	-0.6	0.8	-0.3	-0.7
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.0	-0.3	0.4	0.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	0.3	-0.6	0.2	0.5
Run reversals in cocaine runway, females	0.8	0.8	1.2	0.9	-0.9	0.7	1.1
Run reversals in cocaine runway, males	1.3	1.3	2.1	0.9	-1.1	1.0	1.5
Latency to leave start box in cocaine runway	1.8	2.0	2.6	1.6	-1.6	0.7	1.6
Latency to leave start box in cocaine runway, F	1.5	1.7	4.9	2.2	-0.8	-0.4	1.0
Latency to leave start box in cocaine runway, M	1.9	1.9	3.6	-1.0	-1.2	1.9	1.2
Cd content in liver	0.1	0.1	0.2	0.1	0.3	-0.5	-0.3
Co content in liver	0.4	0.4	0.9	-0.5	-0.6	1.0	0.5
Cu content in liver	0.4	0.4	1.3	1.2	-0.3	-0.5	0.2
Fe content in liver	0.1	0.2	0.5	-0.7	0.2	0.2	-0.2
K content in liver	0.5	0.5	1.3	1.1	-0.5	-0.2	0.5
Mg content in liver	0.7	0.7	2.1	1.4	-0.6	-0.2	0.7
Mn content in liver	3.3	3.7	6.9	2.6	-1.9	0.5	2.0
Na content in liver	0.6	0.7	1.4	0.6	0.7	-1.2	-0.7
Rb content in liver	0.6	0.7	2.0	1.4	0.0	-0.9	0.1
Se content in liver	0.2	0.2	0.3	0.3	-0.5	0.4	0.5
Sr content in liver	0.6	0.6	1.8	-1.3	0.5	0.3	-0.5
Zn content in liver	1.7	1.8	3.6	-1.7	-0.6	1.9	0.7