Tcf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000051499	0.04	0.03	5.2e-05	0.04	0.03	0.04	0.03	8.2e-05	1.2e-04	7.5e-05	1.2e-04
2	Brain	mRNA stability	ENSRNOG00000051499	0.03	0.02	6.0e-03	0.01	0.01	0.04	0.01	1.8e-02	1.3e-02	3.2e-04	3.5e-02
3	IL	intron excision ratio	chr7:9298259:9298434	0.23	0.16	6.1e-04	0.06	0.11	0.09	0.07	1.3e-02	1.1e-03	3.3e-03	7.3e-03
4	IL	intron excision ratio	chr7:9298259:9301283	0.13	0.11	8.1e-03	0.04	0.07	0.05	0.04	3.5e-02	8.3e-03	2.3e-02	3.2e-02
5	Liver	gene expression	ENSRNOG00000051499	0.1	0.06	7.2e-13	0.1	0.1	0.1	0.1	3.2e-11	3.4e-11	2.8e-11	2.4e-11
6	Liver	mRNA stability	ENSRNOG00000051499	0.02	0.02	4.4e-03	0.02	0.01	0.01	0.01	6.3e-03	2.3e-02	2.1e-02	1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	5.2	16.8	22.0	4.7	1.2	4.2	-4.4	-4.5	4.5
BMI without tail	1.4	3.0	4.4	2.1	-0.7	1.6	-1.8	-1.9	1.9
Body weight	0.9	3.8	5.0	2.2	0.4	2.0	-2.1	-2.1	2.1
Epididymis fat weight	0.2	0.6	0.8	-0.7	-0.0	-0.9	0.9	0.7	-0.8
Glucose	1.1	1.6	2.1	1.4	0.1	1.3	-1.4	-1.4	1.4
Heart weight	0.4	0.6	0.9	-0.8	-0.1	-0.9	0.9	0.8	-0.8
Left kidney weight	0.0	0.0	0.0	-0.1	0.0	0.2	-0.1	0.0	-0.1
Right kidney weight	1.1	3.1	4.1	-2.0	-0.5	-1.8	1.9	2.0	-2.0
Tail length	3.0	9.1	10.5	-3.2	-1.8	-3.1	3.2	3.2	-3.2
Length with tail	1.5	5.3	7.1	-2.7	-0.9	-2.3	2.4	2.6	-2.6
Length without tail	0.0	0.1	0.4	-0.1	0.6	0.2	-0.1	0.0	-0.0
Liver weight, left	2.0	3.3	4.0	2.0	1.6	1.7	-1.8	-1.9	1.9
Liver weight, right	1.9	3.2	3.3	1.8	1.8	1.7	-1.7	-1.8	1.8
Parametrial fat weight	0.5	0.9	1.1	-1.0	-0.7	-1.0	1.0	1.0	-1.0
Retroperitoneal fat weight	0.2	0.8	1.0	1.0	0.7	0.7	-0.8	-1.0	1.0
Intraocular pressure	0.2	0.3	0.7	-0.3	0.0	-0.8	0.6	0.5	-0.5
Extensor digitorum longus weight	3.4	13.7	18.0	4.2	1.5	3.6	-3.9	-4.1	4.1
Soleus weight	7.6	22.1	27.6	5.3	1.2	4.9	-5.1	-5.2	5.2
Tibialis anterior weight	1.0	3.5	4.5	2.1	0.2	1.9	-2.0	-2.1	2.1
Tibia length	0.9	2.4	2.9	-1.7	-0.9	-1.6	1.6	1.7	-1.7
Number of licking bursts	0.1	0.1	0.6	-0.1	-0.8	-0.3	0.2	0.2	-0.2
Food consumed during 24 hour testing period	0.5	0.6	0.9	0.7	-0.9	0.7	-0.7	-0.7	0.8
Times rat made contact with spout	0.1	0.1	0.1	0.3	-0.4	0.1	-0.2	-0.3	0.3
Mean time between licks in bursts	4.1	5.7	6.6	-2.5	-1.3	-2.5	2.6	2.6	-2.6
Mean num. licks in bursts	0.1	0.1	0.3	0.3	0.5	0.3	-0.3	-0.3	0.3
Std. dev. time between licks in bursts	1.0	1.2	4.1	-0.9	-2.0	-0.6	0.7	0.8	-0.8
Water consumed over 24 hours	0.7	0.9	1.3	0.9	0.3	1.1	-1.1	-1.0	1.0
Indifference point 0 sec	0.1	0.2	0.3	0.5	-0.3	0.6	-0.5	-0.4	0.5
Indifference point AUC	0.8	1.0	1.3	-1.1	0.2	-1.0	1.0	1.1	-1.1
Indifference point function ln k	0.4	0.6	2.0	0.5	-1.4	0.4	-0.5	-0.6	0.6
Indifference point function log k	0.4	0.6	2.0	0.5	-1.4	0.4	-0.5	-0.6	0.6
Delay discounting total patch changes 0 sec	0.1	0.2	0.2	0.4	-0.4	0.4	-0.4	-0.3	0.4
Delay discounting total patch changes 12 sec	0.1	0.2	0.5	0.5	0.7	0.3	-0.4	-0.4	0.4
Delay discounting total patch changes 18 sec	1.0	1.3	1.6	-1.2	-0.5	-1.2	1.2	1.3	-1.3
Delay discounting total patch changes 24 sec	0.1	0.1	0.2	-0.3	0.5	-0.2	0.3	0.4	-0.3
Delay discounting total patch changes 6 sec	0.2	0.3	0.4	-0.6	0.1	-0.4	0.5	0.6	-0.6
Delay discounting time to switch 0 sec	2.6	4.0	8.6	1.7	2.9	1.9	-1.8	-1.7	1.7
Delay discounting water rate 0 sec	0.8	1.2	5.8	-0.4	-2.4	-0.8	0.6	0.4	-0.4
Delay discounting water rate 12 sec	0.5	0.7	1.6	0.9	-1.3	0.4	-0.6	-0.8	0.8
Delay discounting water rate 18 sec	1.3	1.7	5.5	-0.7	-2.3	-1.4	1.1	0.8	-0.8
Delay discounting water rate 24 sec	0.1	0.2	0.7	0.2	-0.8	-0.5	0.2	-0.0	0.0
Delay discounting water rate 6 sec	1.3	1.9	5.5	-0.9	-2.3	-1.3	1.1	1.0	-1.0
Locomotor activity	2.3	3.6	5.0	-2.2	-1.6	-1.5	1.7	2.1	-2.1
Locomotor testing distance	1.7	2.7	3.4	-1.9	-1.7	-1.4	1.5	1.7	-1.8
Locomotor testing rearing	0.5	0.9	4.5	-0.3	-2.1	-0.4	0.4	0.3	-0.4
Light reinforcement 1	4.4	8.1	10.3	-3.2	-0.1	-2.9	3.1	3.2	-3.2
Light reinforcement 2	1.5	2.0	2.5	-1.6	0.4	-1.4	1.5	1.5	-1.6
Reaction time number correct	0.3	0.4	1.6	0.6	-1.3	0.1	-0.3	-0.5	0.5
Reaction time mean minus median	0.9	1.1	2.0	-1.0	-1.4	-1.0	1.0	0.9	-1.0
Reaction time mean minus median AUC	0.1	0.2	0.6	0.2	-0.8	0.4	-0.3	-0.3	0.2
Reaction time num false alarms	1.0	1.4	8.6	0.1	-2.9	-0.1	-0.0	-0.1	0.1
Reaction time num false alarms AUC	1.0	1.3	7.9	0.2	-2.8	-0.1	-0.0	-0.1	0.2
Reaction time trials correct on left	0.3	0.4	1.6	0.6	-1.3	0.1	-0.3	-0.5	0.5
Reaction time trials on left	0.3	0.5	1.6	0.6	-1.3	0.2	-0.4	-0.6	0.6
Reaction time mean	0.0	0.0	0.1	0.2	-0.1	0.3	-0.3	-0.2	0.2
Reaction time mean AUC	0.1	0.1	0.2	0.3	-0.0	0.4	-0.4	-0.3	0.3
Median of all reaction times	0.4	0.5	0.7	0.7	0.5	0.8	-0.8	-0.7	0.7
Reaction time omissions	0.2	0.2	0.3	-0.6	-0.5	-0.4	0.4	0.5	-0.5
Reaction time false alarm rate	0.4	0.5	3.0	0.1	-1.7	0.1	-0.1	-0.1	0.1
Reaction time premature initiation rate	1.3	1.8	2.2	-1.3	-1.0	-1.5	1.4	1.4	-1.4
Reaction time premature initiations	1.3	1.9	3.0	-1.1	-1.7	-1.5	1.4	1.2	-1.2
Std. dev. reaction times	0.2	0.2	0.3	-0.5	-0.5	-0.4	0.4	0.4	-0.5
Reaction time trials completed	0.3	0.5	1.6	0.6	-1.3	0.2	-0.4	-0.6	0.6
Reaction time trials AUC	0.3	0.4	1.6	0.5	-1.3	0.0	-0.2	-0.5	0.5
Social response proportion	0.9	1.0	3.8	-0.7	2.0	-0.5	0.6	0.7	-0.7
Social responses	5.0	6.4	8.9	-3.0	-0.7	-2.5	2.6	2.8	-2.9
Social time	0.9	1.2	3.2	0.9	1.8	0.9	-0.9	-0.8	0.8
Conditioned locomotion	0.6	0.7	1.2	1.1	-0.1	0.7	-0.9	-1.0	1.0
Cocaine response after cond. corrected	2.9	3.3	4.9	2.2	0.0	1.6	-1.9	-2.1	2.1
Cocaine response after cond. not corrected	3.0	3.3	5.0	2.2	0.1	1.6	-1.9	-2.1	2.1
Cocaine response before conditioning	0.4	0.4	0.5	-0.7	-0.6	-0.6	0.7	0.7	-0.7
Saline control response	0.0	0.0	0.1	0.2	0.3	0.1	-0.1	-0.1	0.1
Condit. Reinf. active minus inactive responses	2.8	3.4	3.9	-1.9	-1.5	-2.0	1.9	1.9	-1.9
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	-0.5	-0.3	-0.8	0.7	0.6	-0.6
Condit. Reinf. active responses	2.3	3.2	3.5	-1.9	-1.5	-1.8	1.8	1.8	-1.8
Condit. Reinf. inactive responses	0.9	1.1	1.4	-1.2	-0.8	-1.1	1.1	1.1	-1.1
Condit. Reinf. lever presses	2.7	3.7	4.1	-1.9	-1.6	-2.0	2.0	2.0	-2.0
Condit. Reinf. lever reinforcers received	1.9	2.7	3.0	-1.7	-1.5	-1.7	1.7	1.7	-1.7
Pavlov. Cond. lever latency	0.9	1.2	1.7	1.1	1.3	1.0	-1.0	-1.1	1.1
Pavlov. Cond. magazine entry latency	0.6	0.6	1.5	-0.7	-1.2	-0.7	0.7	0.7	-0.7
Pavlov. Cond. change in total contacts	0.9	1.2	1.8	-1.1	-1.3	-1.0	1.0	1.1	-1.1
Pavlov. Cond. index score	1.2	1.6	3.6	-1.1	-1.9	-1.1	1.1	1.1	-1.1
Pavlov. Cond. latency score	1.0	1.2	2.7	-1.0	-1.6	-0.9	0.9	1.0	-1.0
Pavlov. Cond. lever contacts	1.0	1.5	2.6	-1.1	-1.6	-1.1	1.1	1.1	-1.1
Pavlov. Cond. magazine entry number	1.0	1.3	3.8	0.9	2.0	0.8	-0.9	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	0.2	0.2	-0.3	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.5	3.2	-1.1	-1.8	-1.0	1.0	1.1	-1.1
Pavlov. Cond. response bias	2.3	3.1	4.5	-1.7	-2.1	-1.7	1.7	1.7	-1.7
Conditioned reinforcement - actives	2.2	2.2	3.0	-1.7	-0.9	-1.4	1.5	1.5	-1.6
Conditioned reinforcement - inactives	0.3	0.3	0.4	0.6	0.5	0.4	-0.5	-0.6	0.6
Conditioned locomotion	6.5	7.9	10.4	-3.2	-1.6	-2.8	2.9	2.9	-3.0
Intermittent access intake day 1-15 change	6.7	6.6	7.9	-2.8	-1.5	-2.6	2.7	2.8	-2.8
Intermittent access intake escalation	7.3	7.2	8.2	-2.9	-1.7	-2.9	2.8	2.9	-2.8
Intermittent access intake escalation 2	8.8	8.7	9.9	-3.1	-1.9	-3.1	3.1	3.1	-3.1
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.6	-0.7	-0.6	-0.7	0.6	0.6	-0.6
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.7	-0.8	-0.3	-0.9	0.8	0.7	-0.8
Intermitt. access escalation Index	0.4	0.4	0.7	0.6	0.4	0.8	-0.7	-0.5	0.6
Intermittent access day 1 total infusions	0.1	0.1	0.1	0.2	-0.0	0.2	-0.2	-0.4	0.3
Intermittent access day 15 total infusions	2.2	2.5	2.9	-1.7	-1.1	-1.7	1.7	1.6	-1.7
Intermittent access terminal intake (last 3 days)	1.2	1.3	1.6	-1.3	-0.9	-1.1	1.1	1.1	-1.2
Intermittent access total infusions	0.3	0.3	0.4	-0.6	-0.4	-0.6	0.6	0.5	-0.6
Intermittent access day 1 locomotion	0.4	0.4	0.5	-0.7	-0.3	-0.7	0.7	0.6	-0.6
Intermittent access day 15 total locomotion	3.3	3.5	4.6	-2.1	-0.7	-2.0	2.0	1.9	-2.0
Intermittent access total locomotion	0.8	0.9	1.5	-1.2	-0.3	-1.0	1.0	1.0	-1.1
Intermittent access standard deviation	2.9	3.1	4.1	-2.0	-0.7	-1.9	1.9	1.8	-1.9
Cocaine induced anxiety	0.3	0.3	0.5	-0.7	0.6	-0.2	0.4	0.6	-0.6
Post-drug Anxiety	0.1	0.1	0.5	-0.4	0.7	-0.1	0.3	0.3	-0.4
Baseline Anxiety	0.3	0.3	0.6	-0.2	-0.8	-0.7	0.6	0.3	-0.4
Lifetime Intake	0.1	0.1	0.1	-0.4	-0.1	-0.3	0.3	0.2	-0.3
Incentive Sensitization - Responses	0.4	0.4	0.5	-0.7	-0.6	-0.6	0.5	0.6	-0.6
Incentive Sensitization - Breakpoint	0.4	0.4	0.5	-0.7	-0.6	-0.6	0.6	0.6	-0.6
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.0	-0.2	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.3	0.1	0.1	-0.2	-0.3	0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.3	-0.1	0.1	0.1	-0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.4	-0.6	-0.5	-0.7	0.6	0.5	-0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.4	-0.7	-0.4	-0.6	0.6	0.5	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.3	0.2	-0.1	0.1	0.1	-0.2
Total sessions with >9 infusions	0.0	0.0	0.1	-0.0	0.1	0.3	-0.2	-0.2	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.5	-0.2	0.7	-0.2	0.2	0.3	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.1	-0.3	0.1	-0.2	0.2	0.3	-0.3
Short access day 1 total infusions	0.0	0.1	0.1	-0.3	0.3	-0.1	0.2	0.2	-0.2
Short access day 10 total infusions	0.0	0.1	0.1	-0.2	-0.1	-0.4	0.3	0.1	-0.2
Short access total infusions	0.0	0.0	0.0	-0.1	0.2	0.1	-0.0	-0.1	0.0
Short access day 1 locomotion	0.6	0.6	1.0	-1.0	-0.3	-0.7	0.8	0.8	-0.9
Short access day 10 total locomotion	4.2	4.6	5.8	-2.4	-1.1	-2.2	2.2	2.2	-2.3
Short access total locomotion	0.8	0.8	1.2	-1.1	-0.5	-0.8	0.9	0.9	-1.0
Compulsive drug intake	1.4	1.4	1.9	1.1	0.7	1.4	-1.3	-1.2	1.2
One hour access (0.3 mA shock)	0.1	0.2	0.3	0.4	0.3	0.3	-0.4	-0.6	0.5
One hour access (shock baseline)	0.2	0.2	0.4	-0.4	-0.3	-0.6	0.5	0.3	-0.4
Number of responses in last shaping day	0.1	0.1	0.3	-0.5	-0.1	-0.4	0.4	0.3	-0.4
Context. condit. distance diff. score	0.2	0.3	0.3	0.6	-0.6	0.4	-0.5	-0.6	0.6
Locomotion velocity, session 1	0.3	0.3	0.9	-0.5	1.0	-0.2	0.3	0.4	-0.4
Locomotion distance, session 1	0.8	1.0	5.4	0.0	2.3	0.6	-0.4	-0.2	0.1
Locomotion velocity, session 2	1.9	2.2	2.8	-1.7	1.6	-1.1	1.4	1.5	-1.5
Locomotion distance, session 2	1.2	1.7	6.7	-1.1	2.6	-0.4	0.7	0.9	-1.0
Locomotion velocity, session 3	5.7	6.6	7.7	-2.7	-1.7	-2.7	2.8	2.7	-2.7
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0	0.0
Stereotopy head waving bouts, day 3	3.6	4.3	5.2	-2.3	-1.2	-2.0	2.2	2.2	-2.2
Stereotopy head waving duration, day 3	4.6	5.6	6.6	-2.6	-1.6	-2.4	2.5	2.5	-2.5
Locomotion velocity, session 7	0.8	0.8	1.7	-0.9	-1.3	-0.7	0.7	0.8	-0.8
Locomotion distance, session 7	0.0	0.0	0.1	0.2	0.4	-0.0	-0.1	-0.1	0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.2	-0.4	0.4	-0.3	-0.3	0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.4	-0.2	-0.7	0.1	0.1	0.1	-0.1
Locomotion velocity, session 8	0.1	0.2	0.6	-0.4	0.8	0.1	0.2	0.3	-0.3
Locomotion distance, session 8	0.1	0.2	0.8	-0.2	0.9	-0.0	0.1	0.2	-0.2
Degree of sensitization distance	0.4	0.4	0.4	0.6	0.5	0.6	-0.7	-0.6	0.6
Degree of sensitization stereotypy	2.1	2.2	2.8	1.6	0.4	1.7	-1.6	-1.6	1.7
Condit. Reinf. active minus inactive responses	3.5	3.9	4.8	-2.1	-0.6	-2.1	2.2	2.1	-2.1
Condit. Reinf. active-inactive response ratio	2.3	2.4	3.2	-1.6	-0.7	-1.8	1.8	1.6	-1.6
Condit. Reinf. active responses	2.3	2.8	3.8	-2.0	-0.0	-1.6	1.8	1.9	-1.9
Condit. Reinf. inactive responses	0.3	0.3	0.5	-0.7	0.6	-0.3	0.5	0.6	-0.7
Incentive salience index mean	1.3	1.6	2.2	-1.5	-0.0	-1.2	1.4	1.4	-1.4
Condit. Reinf. lever presses	0.3	0.4	1.1	0.2	1.0	0.8	-0.5	-0.4	0.4
Time in familiar zone, hab. session 1	2.8	2.7	3.1	-1.5	-1.8	-1.7	1.6	1.6	-1.6
Time in novel zone, hab. session 1	1.6	1.6	1.9	1.1	1.3	1.4	-1.3	-1.2	1.2
Total zone transitions, hab. session 1	0.6	0.8	2.7	-0.9	1.6	-0.4	0.6	0.7	-0.8
Total locomotion distance, hab. session 1	0.5	0.7	2.2	-0.8	1.5	-0.1	0.4	0.6	-0.7
Locomotion velocity, hab. session 1	0.7	1.0	2.3	-1.1	1.5	-0.5	0.8	1.0	-1.0
Time in familiar zone, hab. session 2	7.0	7.3	8.5	-2.7	-2.1	-2.9	2.9	2.8	-2.8
Time in novel zone, hab. session 2	5.1	5.1	6.4	2.3	1.2	2.5	-2.5	-2.4	2.4
Total zone transitions, hab. session 2	2.5	3.2	14.8	0.7	3.8	1.3	-1.0	-0.8	0.8
Total locomotion distance, hab. session 2	0.9	1.2	4.8	-0.8	2.2	-0.4	0.6	0.7	-0.7
Locomotion velocity, hab. session 2	1.1	1.5	7.6	-0.7	2.8	-0.2	0.4	0.6	-0.6
Novel to familiar place preference ratio	4.8	5.1	6.4	2.3	1.3	2.5	-2.5	-2.3	2.4
Novelty place preference	3.1	3.3	4.2	1.8	1.2	2.0	-2.0	-1.9	1.9
Time in novel zone, NPP test	3.4	3.6	4.5	1.9	1.2	2.1	-2.1	-2.0	2.0
Total zone transitions, NPP test	1.5	2.1	11.9	0.2	3.4	0.6	-0.4	-0.3	0.3
Total locomotion distance, NPP test	1.0	1.4	6.9	0.4	2.6	0.8	-0.6	-0.5	0.4
Locomotion velocity, NPP test	0.8	1.2	6.9	0.1	2.6	0.5	-0.3	-0.2	0.2
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.3	-0.4	-0.6	0.5	0.4	-0.3
Pavlov. Cond. magazine entry latency	2.7	3.5	4.2	-2.0	-0.7	-2.0	2.1	2.0	-2.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.2	0.2	-0.2
Pavlov. Cond. index score	0.2	0.2	0.3	-0.6	-0.1	-0.4	0.5	0.5	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.3	0.4	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.1	0.3	0.5	-0.3	-0.2	0.2
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.9	0.3	0.9	-1.0	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	-0.5	-0.2	-0.7	0.6	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.8	-0.4	-0.7	0.8	0.8	-0.8
Pavlov. Cond. response bias	0.9	1.0	1.3	-1.1	-0.2	-1.1	1.1	1.1	-1.1
Bone: apparent density	0.3	0.5	1.2	0.4	0.1	1.1	-0.9	-0.6	0.6
Bone surface	0.1	0.3	0.9	0.0	-0.4	1.0	-0.6	-0.3	0.3
Bone volume	0.2	0.3	1.0	-0.0	-0.5	1.0	-0.6	-0.3	0.2
Bone: connectivity density	0.6	0.9	1.6	0.8	0.4	1.3	-1.1	-1.0	0.9
Bone: cortical apparent density	0.7	0.9	1.0	1.0	0.6	0.9	-1.0	-1.0	1.0
Bone: cortical area	0.7	1.1	1.7	1.0	-0.0	1.3	-1.2	-1.1	1.1
Bone: cortical porosity	0.3	0.3	0.5	-0.7	-0.1	-0.4	0.5	0.6	-0.6
Bone: cortical porosity	0.1	0.1	0.2	0.0	0.5	0.4	-0.3	-0.1	0.1
Bone: cortical thickness	1.2	2.0	2.4	1.4	0.9	1.6	-1.5	-1.5	1.4
Bone: cortical thickness	0.1	0.2	0.6	-0.2	-0.7	-0.4	0.3	0.3	-0.3
Bone: cortical tissue density	0.4	0.6	0.7	0.8	0.5	0.8	-0.8	-0.8	0.8
Bone: elastic displacement	0.3	0.3	0.6	-0.5	-0.8	-0.4	0.4	0.5	-0.5
Bone: elastic work	0.3	0.4	0.5	0.5	-0.7	0.6	-0.6	-0.6	0.6
Bone: endosteal estimation	0.2	0.5	0.6	0.7	-0.5	0.7	-0.7	-0.8	0.8
Bone: endosteal perimeter	0.2	0.4	1.5	-0.5	-1.2	-0.3	0.4	0.4	-0.4
Bone: final force	1.4	2.3	3.0	1.5	0.6	1.7	-1.7	-1.6	1.6
Bone: final moment	1.1	1.8	2.3	1.4	0.5	1.5	-1.5	-1.4	1.4
Bone: marrow area	0.2	0.5	0.7	0.8	-0.5	0.7	-0.7	-0.8	0.8
Bone: maximum diameter	0.3	0.6	0.9	-0.9	-0.8	-0.5	0.7	0.8	-0.8
Bone: maximum force	1.2	2.2	2.7	1.6	0.4	1.6	-1.6	-1.6	1.6
Bone: maximum moment	1.0	1.8	2.2	1.4	0.4	1.5	-1.5	-1.5	1.4
Bone: minimum diameter	0.1	0.2	0.7	0.2	-0.8	0.4	-0.3	-0.3	0.3
Bone: periosteal estimation	0.5	1.0	1.4	1.0	-0.3	1.2	-1.1	-1.1	1.1
Bone: periosteal perimeter	0.1	0.1	0.6	-0.1	-0.8	0.3	-0.1	-0.0	0.0
Bone: post-yield work	0.4	0.6	0.8	0.9	0.2	0.7	-0.8	-0.8	0.8
Bone: stiffness	2.9	4.6	5.5	2.3	0.8	2.3	-2.3	-2.3	2.3
Bone: tissue strength	2.0	1.9	2.1	1.3	1.4	1.4	-1.4	-1.4	1.3
Bone: trabecular number	0.1	0.2	0.5	-0.7	0.1	-0.2	0.4	0.6	-0.6
Bone: trabecular spacing	0.1	0.1	0.6	0.3	-0.7	-0.4	0.1	-0.1	0.1
Bone: trabecular thickness	0.6	0.7	1.9	0.4	-0.0	1.4	-1.1	-0.7	0.6
Bone: trabecular tissue density	1.2	1.6	2.1	1.5	0.9	1.2	-1.3	-1.4	1.4
Breakpoint value in progressive ratio session	6.0	6.7	7.3	-2.7	-2.3	-2.6	2.7	2.7	-2.6
Distance traveled before self-admin	0.6	0.7	0.8	0.6	0.9	0.9	-0.9	-0.8	0.8
Distance traveled after self-admin	0.4	0.4	0.7	-0.8	-0.2	-0.6	0.7	0.7	-0.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.4	-0.3	-0.1	-0.2	-0.3	0.4
Delta time in open arm before/after self-admin	1.5	1.5	1.6	1.2	1.3	1.2	-1.2	-1.2	1.1
Diff in mean of infusions in LGA sessions	1.6	1.8	2.1	-1.3	-1.0	-1.4	1.5	1.5	-1.3
Extinction: sum of active levers before priming	1.8	1.8	2.0	-1.4	-1.1	-1.4	1.4	1.4	-1.3
Active lever presses in extinction session 6	2.4	2.3	3.1	-1.8	-1.1	-1.5	1.5	1.7	-1.5
Delta distance traveled before/after self-admin	1.5	1.6	2.0	-1.3	-0.8	-1.3	1.3	1.4	-1.4
Delta ambulatory time before/after self-admin	1.4	1.5	2.0	-1.3	-0.5	-1.3	1.3	1.4	-1.3
Time in closed arm before self-admin	1.5	1.7	2.8	1.1	1.7	1.4	-1.2	-1.1	1.2
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2	0.3	-0.1
Time in open arm before self-admin	1.4	1.5	3.7	-1.1	-1.9	-1.0	1.0	1.0	-0.9
Time in open arm after self-admin	0.6	0.7	1.0	0.9	0.0	0.9	-0.9	-1.0	0.9
Sum of active levers in priming session hrs 5-6	0.1	0.0	0.3	-0.1	0.5	0.1	-0.0	0.0	0.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	-0.5	0.5	-0.2	0.3	0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.5	0.6	1.1	-0.4	-1.1	-0.8	0.7	0.6	-0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	0.4	0.0	0.1	0.3	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.4	0.5	-0.3	0.4	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	1.2	0.4	-1.1	-0.1	-0.1	-0.2	0.1
Delta time to tail flick, test, before/after SA	0.3	0.2	0.5	-0.4	0.2	-0.7	0.6	0.4	-0.5
Ambulatory time before self-admin	0.5	0.5	0.6	0.5	0.6	0.8	-0.8	-0.7	0.7
Ambulatory time after self-admin	0.2	0.2	0.4	-0.6	0.2	-0.4	0.5	0.5	-0.5
Total heroin consumption	2.0	2.4	2.6	-1.6	-1.6	-1.4	1.5	1.6	-1.5
Area under the delay curve	2.2	2.4	3.0	1.7	-0.4	1.6	-1.7	-1.7	1.7
Delay disc. indifference point, 0s delay	8.8	9.5	11.6	3.1	2.3	3.4	-3.3	-3.2	3.2
Delay disc. indifference point, 16s delay	0.3	0.3	1.1	0.4	-1.0	0.4	-0.4	-0.5	0.5
Delay disc. indifference point, 2s delay	5.7	6.3	7.6	2.7	0.8	2.8	-2.7	-2.7	2.7
Delay disc. indifference point, 24s delay	0.8	0.8	1.8	0.8	-1.3	0.7	-0.8	-0.8	0.8
Delay disc. indifference point, 4s delay	1.5	1.6	1.8	1.2	-1.3	1.2	-1.2	-1.3	1.3
Delay disc. indifference point, 8s delay	0.9	0.9	1.1	1.1	0.3	0.9	-1.0	-1.1	1.0
Delay discount exponential model param	2.0	2.1	2.7	-1.6	0.5	-1.5	1.6	1.6	-1.6
Delay discount hyperbolic model param	2.8	3.0	3.7	-1.9	0.5	-1.8	1.9	1.9	-1.9
Fecal boli incidents, locomotor time 1	2.2	2.4	6.9	1.3	2.6	1.2	-1.2	-1.2	1.2
Change in fecal boli incidents, locomotor task	0.6	0.6	2.9	-0.4	-1.7	-0.1	0.2	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.2	0.6	0.9	1.1	-1.0	-0.7	0.7
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.5	0.6	-0.5	0.5	0.5	-0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.5	0.3	-0.5	0.5	0.5	-0.5
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.4	0.0	-0.3	0.4	0.4	-0.4
Distance moved, locomotor task time 1	0.7	0.8	1.2	0.8	-0.7	1.1	-1.0	-0.8	0.8
Vertical activity count, locomotor time 1	0.4	0.4	2.1	0.2	-1.5	0.1	-0.2	-0.2	0.2
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.2	1.0	0.6	1.0	-1.1	-0.9	1.0
Bouts of movement, locomotor time 2	0.2	0.2	0.4	-0.5	0.7	-0.2	0.3	0.4	-0.4
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.4	0.4	-0.1	0.3	0.3	-0.3
Rest time, locomotor task time 2	0.3	0.3	0.5	-0.7	-0.1	-0.5	0.6	0.6	-0.6
Distance moved, locomotor task time 2	0.4	0.5	0.7	0.8	-0.1	0.7	-0.8	-0.8	0.8
Vertical activity count, locomotor time 2	0.3	0.3	0.5	0.7	0.2	0.4	-0.5	-0.6	0.6
Weight adjusted by age	0.1	0.1	0.3	0.3	-0.5	0.1	-0.2	-0.2	0.3
Seeking ratio, delayed vs. immediate footshock	3.6	4.1	5.1	-2.3	-1.5	-1.9	2.1	2.2	-2.2
Locomotion in novel chamber	0.4	0.5	0.5	-0.7	-0.5	-0.7	0.7	0.7	-0.7
Locomotion in novel chamber post-restriction	2.1	2.5	9.1	-1.0	-3.0	-1.1	1.1	1.0	-1.0
Progressive ratio	0.8	0.9	4.9	0.5	2.2	0.3	-0.3	-0.4	0.4
Food seeking constrained by brief footshock	0.2	0.2	1.0	-0.3	1.0	-0.3	0.3	0.3	-0.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.4	-0.6	-0.2	0.3	0.4	-0.4
Run reversals in cocaine runway, females	0.3	0.3	0.7	-0.6	-0.8	-0.4	0.5	0.4	-0.5
Run reversals in cocaine runway, males	0.9	0.9	1.1	-1.1	-0.4	-1.0	1.1	1.0	-1.0
Latency to leave start box in cocaine runway	0.8	0.8	3.0	-0.9	-1.7	-0.3	0.5	0.6	-0.7
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	0.1	-0.1	0.9	-0.7	-0.5	0.4
Latency to leave start box in cocaine runway, M	4.1	3.9	5.4	-1.8	-2.3	-2.0	1.9	1.9	-1.9
Cd content in liver	0.3	0.3	0.5	0.5	0.7	0.6	-0.6	-0.5	0.5
Co content in liver	0.5	0.6	0.8	-0.8	-0.1	-0.8	0.8	0.9	-0.9
Cu content in liver	0.5	0.6	1.5	0.5	1.2	0.8	-0.7	-0.6	0.6
Fe content in liver	0.1	0.1	0.4	-0.2	0.6	-0.4	0.3	0.3	-0.3
K content in liver	0.3	0.3	0.9	0.2	1.0	0.6	-0.5	-0.3	0.3
Mg content in liver	0.2	0.3	0.5	0.3	0.7	0.7	-0.5	-0.4	0.4
Mn content in liver	0.1	0.2	0.4	-0.6	0.1	0.0	0.2	0.5	-0.5
Na content in liver	1.9	2.0	3.5	1.2	1.9	1.5	-1.4	-1.2	1.2
Rb content in liver	0.8	1.0	1.4	0.8	0.9	1.2	-1.1	-0.9	0.9
Se content in liver	0.2	0.2	0.4	-0.4	0.6	-0.3	0.4	0.4	-0.4
Sr content in liver	0.1	0.1	0.2	-0.2	-0.3	-0.5	0.4	0.3	-0.3
Zn content in liver	2.7	3.0	4.1	-1.7	-1.1	-2.0	1.9	1.8	-1.7