Hub : Genes

Kremen1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000051487 0.11 0.09 1.4e-06 0.05 0.04 0.04 0.04 5.6e-06 1.2e-05 9.2e-06 8e-06
2 BLA gene expression ENSRNOG00000051487 0.17 0.11 1.2e-07 0.11 0.12 0.12 0.12 1.3e-06 5.7e-07 9.9e-07 7e-07
3 Brain gene expression ENSRNOG00000051487 0.04 0.03 2.9e-04 0.02 0.03 0.03 0.03 3.4e-03 6.1e-04 1.9e-03 1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.00.00.0-0.10.10.1
BMI without tail0.00.00.1-0.20.30.1
Body weight1.35.55.92.3-2.3-2.4
Epididymis fat weight0.40.91.1-1.01.10.7
Glucose18.828.832.55.6-5.7-4.7
Heart weight0.40.60.7-0.80.70.9
Left kidney weight0.00.10.1-0.20.40.2
Right kidney weight0.82.22.8-1.41.71.4
Tail length1.44.35.22.1-1.9-2.3
Length with tail2.38.38.83.0-2.7-2.9
Length without tail1.53.23.71.9-1.8-1.7
Liver weight, left1.72.83.3-1.61.81.6
Liver weight, right3.35.56.2-2.32.52.3
Parametrial fat weight2.14.24.82.2-2.2-1.7
Retroperitoneal fat weight0.00.00.1-0.20.10.2
Intraocular pressure0.30.40.60.7-0.8-0.5
Extensor digitorum longus weight3.313.414.63.5-3.6-3.8
Soleus weight0.82.52.81.6-1.4-1.7
Tibialis anterior weight1.34.44.62.2-2.1-2.1
Tibia length0.00.10.2-0.30.40.1
Number of licking bursts3.13.74.21.8-1.9-2.0
Food consumed during 24 hour testing period1.92.32.81.4-1.7-1.5
Times rat made contact with spout0.10.10.20.3-0.4-0.0
Mean time between licks in bursts0.60.81.01.0-1.0-0.6
Mean num. licks in bursts2.02.43.2-1.41.41.8
Std. dev. time between licks in bursts0.00.00.0-0.1-0.00.1
Water consumed over 24 hours1.41.61.91.2-1.4-1.2
Indifference point 0 sec2.03.23.31.8-1.7-1.8
Indifference point AUC0.10.10.20.3-0.4-0.4
Indifference point function ln k0.00.10.1-0.30.30.0
Indifference point function log k0.00.10.1-0.30.30.0
Delay discounting total patch changes 0 sec2.03.33.41.8-1.8-1.8
Delay discounting total patch changes 12 sec1.31.71.71.3-1.3-1.3
Delay discounting total patch changes 18 sec2.22.93.31.8-1.8-1.5
Delay discounting total patch changes 24 sec0.60.81.2-0.70.81.1
Delay discounting total patch changes 6 sec1.82.83.01.6-1.7-1.7
Delay discounting time to switch 0 sec0.40.50.7-0.60.80.8
Delay discounting water rate 0 sec1.72.82.91.6-1.7-1.7
Delay discounting water rate 12 sec0.00.00.1-0.1-0.2-0.2
Delay discounting water rate 18 sec0.10.10.2-0.30.40.1
Delay discounting water rate 24 sec0.00.10.10.3-0.3-0.1
Delay discounting water rate 6 sec0.30.40.50.6-0.6-0.7
Locomotor activity0.81.31.71.3-1.2-0.9
Locomotor testing distance0.20.30.40.5-0.4-0.6
Locomotor testing rearing2.03.13.11.8-1.7-1.8
Light reinforcement 10.10.10.20.3-0.2-0.5
Light reinforcement 20.10.20.30.5-0.2-0.4
Reaction time number correct0.00.00.00.1-0.2-0.1
Reaction time mean minus median1.51.92.5-1.31.31.6
Reaction time mean minus median AUC1.31.61.7-1.31.21.3
Reaction time num false alarms0.10.10.3-0.0-0.2-0.5
Reaction time num false alarms AUC0.10.10.2-0.2-0.1-0.5
Reaction time trials correct on left0.00.00.00.1-0.2-0.1
Reaction time trials on left0.00.00.00.0-0.2-0.1
Reaction time mean0.81.11.4-1.01.01.2
Reaction time mean AUC1.31.82.0-1.31.31.4
Median of all reaction times0.40.60.7-0.70.70.8
Reaction time omissions1.72.32.5-1.61.51.5
Reaction time false alarm rate0.10.10.2-0.20.0-0.4
Reaction time premature initiation rate3.34.55.1-2.32.21.9
Reaction time premature initiations1.82.63.1-1.81.61.4
Std. dev. reaction times1.31.82.4-1.31.21.5
Reaction time trials completed0.00.00.00.0-0.2-0.1
Reaction time trials AUC0.00.10.10.2-0.3-0.2
Social response proportion1.71.82.41.3-1.5-1.2
Social responses2.02.63.21.6-1.8-1.5
Social time0.10.20.30.3-0.5-0.3
Conditioned locomotion1.41.61.9-1.31.41.1
Cocaine response after cond. corrected2.02.32.51.6-1.4-1.5
Cocaine response after cond. not corrected2.22.52.61.6-1.5-1.6
Cocaine response before conditioning0.30.40.5-0.70.70.6
Saline control response0.81.01.1-1.10.91.0
Condit. Reinf. active minus inactive responses0.50.60.7-0.80.80.8
Condit. Reinf. active-inactive response ratio0.00.00.0-0.20.10.2
Condit. Reinf. active responses0.70.91.0-0.90.91.0
Condit. Reinf. inactive responses0.70.91.1-0.90.91.1
Condit. Reinf. lever presses0.60.80.9-1.00.90.8
Condit. Reinf. lever reinforcers received0.60.80.9-0.90.80.9
Pavlov. Cond. lever latency3.95.36.32.2-2.2-2.5
Pavlov. Cond. magazine entry latency0.00.00.1-0.30.20.1
Pavlov. Cond. change in total contacts0.20.30.4-0.40.50.7
Pavlov. Cond. index score1.41.92.0-1.31.31.4
Pavlov. Cond. latency score1.62.02.0-1.41.41.4
Pavlov. Cond. lever contacts3.04.25.2-1.92.02.3
Pavlov. Cond. magazine entry number0.00.00.00.2-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.00.00.00.0-0.00.0
Pavlov. Cond. lever-magazine prob. diff.1.41.81.9-1.31.31.4
Pavlov. Cond. response bias1.21.72.2-1.21.21.5
Conditioned reinforcement - actives0.00.00.00.2-0.10.0
Conditioned reinforcement - inactives0.10.10.20.4-0.3-0.2
Conditioned locomotion0.10.10.20.4-0.1-0.2
Intermittent access intake day 1-15 change0.20.20.30.4-0.5-0.3
Intermittent access intake escalation0.10.10.10.2-0.3-0.2
Intermittent access intake escalation 20.00.00.10.1-0.3-0.2
Intermitt. access day 1 inactive lever presses1.11.21.4-1.21.01.1
Intermitt. access day 15 inactive lever presses0.70.81.10.9-1.0-0.7
Intermitt. access escalation Index0.10.00.10.1-0.3-0.2
Intermittent access day 1 total infusions0.00.10.10.30.20.2
Intermittent access day 15 total infusions0.30.40.70.8-0.5-0.4
Intermittent access terminal intake (last 3 days)0.30.30.50.7-0.4-0.3
Intermittent access total infusions0.20.20.40.7-0.3-0.3
Intermittent access day 1 locomotion0.60.60.8-0.50.90.9
Intermittent access day 15 total locomotion0.30.30.50.7-0.6-0.4
Intermittent access total locomotion0.40.40.80.9-0.6-0.5
Intermittent access standard deviation1.31.41.4-1.11.21.2
Cocaine induced anxiety2.83.23.51.7-1.8-1.9
Post-drug Anxiety0.91.01.21.0-1.1-1.0
Baseline Anxiety0.20.20.3-0.30.40.6
Lifetime Intake0.20.30.60.8-0.3-0.4
Incentive Sensitization - Responses0.00.00.10.3-0.2-0.1
Incentive Sensitization - Breakpoint0.00.00.00.2-0.2-0.0
Progressive ratio test 1 active lever presses0.10.10.20.4-0.2-0.1
Progressive ratio test 1 breakpoint0.00.00.10.10.20.3
Progressive ratio test 1 inactive lever presses2.32.52.51.6-1.6-1.6
Progressive ratio test 2 active lever presses0.10.10.20.4-0.2-0.2
Progressive ratio test 2 breakpoint0.10.10.20.4-0.3-0.2
Progressive ratio test 2 inactive lever presses0.70.81.11.0-0.9-0.7
Total sessions with >9 infusions0.00.00.0-0.00.1-0.0
Short access day 1 total inactive lever presses3.84.34.62.1-2.0-2.1
Short access day 10 total inactive lever presses0.40.40.6-0.80.60.6
Short access day 1 total infusions0.20.20.3-0.30.50.3
Short access day 10 total infusions0.10.10.20.10.40.3
Short access total infusions0.10.10.3-0.10.50.3
Short access day 1 locomotion1.41.52.0-1.21.41.1
Short access day 10 total locomotion0.40.50.6-0.50.80.7
Short access total locomotion3.03.13.7-1.61.91.7
Compulsive drug intake3.13.03.5-1.91.71.6
One hour access (0.3 mA shock)0.00.10.10.4-0.1-0.1
One hour access (shock baseline)1.21.42.11.4-1.1-1.0
Number of responses in last shaping day0.00.00.1-0.30.20.1
Context. condit. distance diff. score4.35.25.3-2.32.32.3
Locomotion velocity, session 10.10.10.10.3-0.30.2
Locomotion distance, session 10.71.01.2-1.11.00.8
Locomotion velocity, session 20.00.00.10.1-0.20.1
Locomotion distance, session 21.72.52.8-1.71.51.6
Locomotion velocity, session 33.03.54.2-2.11.91.7
Locomotion distance, session 30.00.00.1-0.2-0.1-0.3
Stereotopy head waving bouts, day 31.11.31.5-1.21.21.0
Stereotopy head waving duration, day 31.92.32.6-1.41.51.6
Locomotion velocity, session 70.10.20.20.4-0.4-0.4
Locomotion distance, session 70.30.40.4-0.70.60.6
Stereotopy head waving bouts, day 70.40.40.5-0.60.70.7
Stereotopy head waving duration, day 70.00.00.0-0.20.20.1
Locomotion velocity, session 81.51.72.0-1.31.21.4
Locomotion distance, session 88.612.813.2-3.63.53.6
Degree of sensitization distance1.81.92.5-1.21.31.6
Degree of sensitization stereotypy0.10.10.20.4-0.3-0.3
Condit. Reinf. active minus inactive responses0.70.81.00.9-1.0-0.8
Condit. Reinf. active-inactive response ratio0.10.10.10.3-0.30.2
Condit. Reinf. active responses0.30.30.40.5-0.7-0.5
Condit. Reinf. inactive responses0.10.10.30.1-0.2-0.6
Incentive salience index mean1.01.21.41.0-1.2-1.0
Condit. Reinf. lever presses0.10.20.30.3-0.4-0.6
Time in familiar zone, hab. session 10.20.10.2-0.40.40.3
Time in novel zone, hab. session 10.50.50.50.7-0.6-0.7
Total zone transitions, hab. session 10.00.00.0-0.0-0.1-0.1
Total locomotion distance, hab. session 10.10.10.20.3-0.3-0.4
Locomotion velocity, hab. session 10.00.00.00.1-0.1-0.1
Time in familiar zone, hab. session 21.71.82.1-1.21.31.5
Time in novel zone, hab. session 22.52.53.11.4-1.6-1.8
Total zone transitions, hab. session 20.60.81.00.8-0.9-1.0
Total locomotion distance, hab. session 20.81.01.10.9-1.1-1.0
Locomotion velocity, hab. session 21.01.41.51.1-1.2-1.2
Novel to familiar place preference ratio1.11.11.41.2-1.1-0.9
Novelty place preference1.21.21.51.2-1.1-0.9
Time in novel zone, NPP test1.11.21.41.2-1.1-0.9
Total zone transitions, NPP test0.50.81.0-1.00.90.7
Total locomotion distance, NPP test0.10.20.2-0.50.40.3
Locomotion velocity, NPP test0.00.00.0-0.20.20.0
Pavlov. Cond. lever latency0.70.91.11.1-1.0-0.7
Pavlov. Cond. magazine entry latency2.63.44.0-2.01.81.7
Pavlov. Cond. change in total contacts0.70.81.00.7-0.9-1.0
Pavlov. Cond. index score2.93.74.4-2.11.91.7
Pavlov. Cond. latency score2.33.03.5-1.91.71.6
Pavlov. Cond. lever contacts1.31.52.0-1.41.21.0
Pavlov. Cond. magazine entry number3.03.84.52.1-1.9-1.8
Pavlov. Cond. intertrial magazine entries0.40.50.60.8-0.6-0.8
Pavlov. Cond. lever-magazine prob. diff.3.44.35.1-2.22.11.9
Pavlov. Cond. response bias1.72.12.9-1.71.41.2
Bone: apparent density0.10.20.4-0.60.50.2
Bone surface0.20.30.50.3-0.6-0.7
Bone volume0.10.20.40.2-0.5-0.7
Bone: connectivity density0.30.40.6-0.80.60.5
Bone: cortical apparent density0.81.01.11.0-1.0-1.1
Bone: cortical area3.24.95.32.2-2.2-2.3
Bone: cortical porosity0.00.00.10.2-0.2-0.3
Bone: cortical porosity0.10.10.2-0.40.40.3
Bone: cortical thickness1.83.03.91.6-1.6-2.0
Bone: cortical thickness0.60.70.9-1.00.90.6
Bone: cortical tissue density0.91.11.21.0-1.1-1.1
Bone: elastic displacement0.60.70.8-0.90.90.7
Bone: elastic work0.00.00.1-0.00.0-0.3
Bone: endosteal estimation0.10.20.30.5-0.5-0.4
Bone: endosteal perimeter0.81.61.91.4-1.2-1.2
Bone: final force0.40.60.70.7-0.7-0.8
Bone: final moment0.50.91.00.9-0.9-1.0
Bone: marrow area0.10.10.20.4-0.4-0.3
Bone: maximum diameter5.39.710.13.1-3.2-3.0
Bone: maximum force0.30.50.60.7-0.7-0.8
Bone: maximum moment0.50.81.00.8-0.8-1.0
Bone: minimum diameter0.00.00.0-0.00.0-0.1
Bone: periosteal estimation1.22.42.51.6-1.5-1.6
Bone: periosteal perimeter2.13.53.81.9-1.8-1.9
Bone: post-yield work0.20.30.30.6-0.6-0.6
Bone: stiffness0.00.00.00.1-0.00.0
Bone: tissue strength0.10.10.10.4-0.3-0.1
Bone: trabecular number0.00.10.1-0.30.30.1
Bone: trabecular spacing1.21.51.71.3-1.3-1.1
Bone: trabecular thickness1.51.82.2-1.51.41.1
Bone: trabecular tissue density0.20.20.4-0.30.40.7
Breakpoint value in progressive ratio session1.71.91.91.4-1.4-1.3
Distance traveled before self-admin0.30.40.50.6-0.5-0.7
Distance traveled after self-admin0.20.20.30.3-0.3-0.6
Delta time in closed arm before/after self-admin6.56.36.5-2.42.52.5
Delta time in open arm before/after self-admin9.69.29.73.1-3.0-2.9
Diff in mean of infusions in LGA sessions0.10.20.2-0.20.50.4
Extinction: sum of active levers before priming0.50.50.60.7-0.8-0.6
Active lever presses in extinction session 60.20.20.30.6-0.4-0.5
Delta distance traveled before/after self-admin0.40.40.5-0.70.60.6
Delta ambulatory time before/after self-admin0.80.91.2-1.10.80.9
Time in closed arm before self-admin0.40.50.70.5-0.7-0.8
Time in closed arm after self-admin2.32.42.8-1.71.51.4
Time in open arm before self-admin2.83.03.3-1.61.81.8
Time in open arm after self-admin0.40.40.70.9-0.6-0.3
Sum of active levers in priming session hrs 5-60.60.60.80.6-0.8-0.9
Time to tail flick, vehicle, before self-admin0.00.00.0-0.20.20.1
Time to tail flick, vehicle, after self-admin0.00.00.1-0.20.20.0
Time to tail flick, test, before self-admin0.60.60.6-0.80.80.8
Time to tail flick, test, after self-admin3.03.13.61.7-1.7-1.9
Delta time to tail flick, vehicle, before/after SA0.00.00.00.1-0.0-0.0
Delta time to tail flick, test, before/after SA2.11.92.01.4-1.4-1.4
Ambulatory time before self-admin0.80.81.10.9-0.7-1.1
Ambulatory time after self-admin0.20.30.40.4-0.4-0.6
Total heroin consumption0.10.10.20.4-0.3-0.3
Area under the delay curve4.14.45.02.2-2.0-2.0
Delay disc. indifference point, 0s delay1.11.21.31.1-1.1-1.1
Delay disc. indifference point, 16s delay3.63.64.42.1-1.9-1.7
Delay disc. indifference point, 2s delay1.21.31.61.2-1.0-1.3
Delay disc. indifference point, 24s delay1.51.51.61.2-1.2-1.1
Delay disc. indifference point, 4s delay3.33.43.81.8-1.8-1.9
Delay disc. indifference point, 8s delay1.41.51.81.4-1.2-1.1
Delay discount exponential model param3.74.04.5-2.11.91.9
Delay discount hyperbolic model param3.74.04.4-2.11.92.0
Fecal boli incidents, locomotor time 10.30.30.4-0.60.50.5
Change in fecal boli incidents, locomotor task0.10.10.10.3-0.3-0.0
Time >=10cm from walls, locomotor time 10.00.00.0-0.10.10.2
Bouts of movement, locomotor time 10.60.70.91.0-0.9-0.6
Total resting periods, locomotor time 10.20.20.30.6-0.6-0.2
Rest time, locomotor task time 10.00.00.00.1-0.2-0.0
Distance moved, locomotor task time 10.20.20.30.4-0.4-0.6
Vertical activity count, locomotor time 10.10.10.10.3-0.3-0.4
Time >=10cm from walls, locomotor time 20.10.10.2-0.10.30.5
Bouts of movement, locomotor time 20.00.00.00.00.10.1
Total resting periods, locomotor time 20.00.00.00.10.00.0
Rest time, locomotor task time 20.10.10.1-0.30.20.2
Distance moved, locomotor task time 20.00.10.1-0.20.20.2
Vertical activity count, locomotor time 20.00.00.0-0.10.10.1
Weight adjusted by age0.60.70.90.8-0.8-1.0
Seeking ratio, delayed vs. immediate footshock0.20.20.3-0.20.40.6
Locomotion in novel chamber4.65.66.0-2.32.42.3
Locomotion in novel chamber post-restriction3.33.94.8-1.91.92.2
Progressive ratio0.00.00.1-0.10.20.2
Food seeking constrained by brief footshock2.12.63.31.5-1.4-1.8
Seeking ratio, punishment vs. effort0.91.21.41.0-1.0-1.2
Run reversals in cocaine runway, females0.80.80.8-0.90.80.9
Run reversals in cocaine runway, males0.60.50.60.8-0.7-0.7
Latency to leave start box in cocaine runway0.00.00.0-0.0-0.0-0.2
Latency to leave start box in cocaine runway, F0.40.40.60.5-0.6-0.8
Latency to leave start box in cocaine runway, M0.70.60.8-0.70.80.9
Cd content in liver0.30.30.4-0.60.60.5
Co content in liver0.00.00.1-0.30.1-0.0
Cu content in liver0.40.50.50.6-0.7-0.7
Fe content in liver0.30.30.7-0.40.40.8
K content in liver0.50.50.90.4-0.5-1.0
Mg content in liver0.30.30.50.3-0.5-0.7
Mn content in liver0.10.10.2-0.10.0-0.5
Na content in liver4.54.85.02.2-2.2-2.1
Rb content in liver3.03.84.41.9-1.9-2.1
Se content in liver1.51.82.31.2-1.3-1.5
Sr content in liver2.01.82.21.5-1.4-1.2
Zn content in liver0.20.30.40.4-0.5-0.6