| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000050998 | 0.3900 | 0.1100 | 0.0e+00 | 0.451 | 0.418 | 0.457 | 0.462 | 2.4e-55 | 4.1e-50 | 2.8e-56 | 4.9e-57 |
| 2 | Brain | gene expression | ENSRNOG00000050998 | 0.0490 | 0.0360 | 8.5e-04 | 0.030 | 0.031 | 0.028 | 0.027 | 8.5e-04 | 7.2e-04 | 1.2e-03 | 1.4e-03 |
| 3 | Liver | gene expression | ENSRNOG00000050998 | 0.0930 | 0.0670 | 6.7e-06 | 0.039 | 0.042 | 0.044 | 0.040 | 3.2e-05 | 1.6e-05 | 1.1e-05 | 3.0e-05 |
| 4 | NAcc | gene expression | ENSRNOG00000050998 | 0.0530 | 0.0390 | 7.6e-04 | 0.015 | 0.009 | 0.015 | -0.002 | 2.7e-02 | 6.9e-02 | 2.7e-02 | 5.0e-01 |
| 5 | PL | gene expression | ENSRNOG00000050998 | 0.0423 | 0.0335 | 9.3e-03 | 0.002 | 0.022 | 0.019 | 0.014 | 2.2e-01 | 7.3e-03 | 1.2e-02 | 2.9e-02 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|---|---|---|
| Epididymis fat weight | 9.2 | 21.5 | 35.1 | 4.0 | 5.8 | 3.5 | 3.3 | 5.9 |
| Context. condit. distance diff. score | 6.2 | 7.5 | 12.1 | -3.5 | -2.4 | 0.1 | -3.3 | -3.0 |
| Glucose | 5.7 | 8.8 | 15.3 | -2.5 | -3.9 | -2.0 | -1.9 | -3.9 |
| Mn content in liver | 5.4 | 6.2 | 10.4 | -2.3 | -3.1 | -1.5 | -1.8 | -3.2 |
| Reaction time mean minus median | 5.3 | 6.8 | 12.2 | -1.7 | -3.5 | -2.6 | -1.1 | -3.3 |
| Std. dev. reaction times | 5.1 | 7.0 | 12.9 | -1.6 | -3.6 | -2.7 | -1.0 | -3.4 |
| Reaction time mean AUC | 4.5 | 6.0 | 10.2 | -1.9 | -3.2 | -1.9 | -1.5 | -3.2 |
| Bone: cortical thickness | 4.4 | 7.2 | 10.6 | 3.3 | 2.6 | 0.6 | 3.0 | 3.1 |
| Reaction time mean | 4.2 | 5.8 | 9.9 | -1.9 | -3.1 | -1.8 | -1.5 | -3.2 |
| Locomotion velocity, session 8 | 4.1 | 5.0 | 8.9 | -1.5 | -3.0 | -2.1 | -1.0 | -2.9 |
| Pavlov. Cond. index score | 4.1 | 5.2 | 8.7 | -2.2 | -2.8 | -1.2 | -1.9 | -3.0 |
| Pavlov. Cond. lever-magazine prob. diff. | 4.1 | 5.1 | 8.4 | -2.2 | -2.7 | -1.1 | -2.0 | -2.9 |
| Rest time, locomotor task time 2 | 4.1 | 4.7 | 8.1 | -1.6 | -2.8 | -2.0 | -1.1 | -2.8 |
| Se content in liver | 4.1 | 5.0 | 7.9 | -2.0 | -2.7 | -1.6 | -1.7 | -2.8 |
| Bone: final force | 4.0 | 6.6 | 12.9 | 3.6 | 1.3 | -1.0 | 3.6 | 2.2 |
| Pavlov. Cond. response bias | 3.9 | 4.8 | 7.6 | -2.2 | -2.5 | -0.9 | -2.0 | -2.8 |
| Bone: endosteal estimation | 3.8 | 8.2 | 17.2 | 0.1 | -3.8 | -4.1 | 0.9 | -3.0 |
| Tail length | 3.7 | 11.2 | 27.6 | 1.9 | -3.5 | -5.3 | 2.8 | -2.2 |
| Liver weight, right | 3.7 | 6.1 | 14.7 | 0.8 | -2.9 | -3.8 | 1.4 | -2.1 |
| Reaction time mean minus median AUC | 3.7 | 4.8 | 8.1 | -1.6 | -2.8 | -2.0 | -1.2 | -2.8 |
| Pavlov. Cond. latency score | 3.7 | 4.7 | 8.0 | -1.9 | -2.8 | -1.4 | -1.6 | -2.8 |
| Bone: marrow area | 3.7 | 8.0 | 16.9 | 0.1 | -3.7 | -4.1 | 0.9 | -2.9 |
| Delay discounting total patch changes 18 sec | 3.6 | 4.8 | 8.0 | 1.4 | 2.8 | 2.3 | 1.0 | 2.7 |
| Delay discounting total patch changes 24 sec | 3.6 | 4.5 | 8.2 | 0.9 | 2.9 | 2.6 | 0.2 | 2.5 |
| Bone: endosteal perimeter | 3.5 | 7.1 | 13.5 | -1.5 | -3.7 | -2.7 | -0.8 | -3.4 |
| Bone: final moment | 3.5 | 5.8 | 11.6 | 3.3 | 1.1 | -1.0 | 3.4 | 2.0 |
| Delay disc. indifference point, 16s delay | 3.5 | 3.5 | 5.5 | 2.0 | 2.1 | 0.7 | 1.7 | 2.4 |
| Body weight | 3.2 | 13.4 | 26.6 | 4.5 | -1.0 | -4.4 | 5.2 | 0.7 |
| Reaction time omissions | 3.2 | 4.3 | 7.3 | -1.5 | -2.7 | -1.8 | -1.2 | -2.7 |
| Pavlov. Cond. magazine entry latency | 3.2 | 4.1 | 6.8 | -2.0 | -2.4 | -0.9 | -1.7 | -2.6 |
| Social time | 3.1 | 4.1 | 7.9 | -1.0 | -2.8 | -2.2 | -0.6 | -2.6 |
| Locomotion distance, session 8 | 3.1 | 4.5 | 7.5 | -2.7 | -1.7 | 0.3 | -2.6 | -2.3 |
| Condit. Reinf. lever presses | 3.1 | 4.2 | 6.1 | -2.5 | -1.9 | -0.1 | -2.3 | -2.4 |
| Pavlov. Cond. lever latency | 3.1 | 3.9 | 6.5 | 1.8 | 2.4 | 1.1 | 1.6 | 2.6 |
| Mean time between licks in bursts | 3.0 | 4.2 | 7.5 | -1.5 | -2.7 | -1.8 | -1.0 | -2.7 |
| Bone: maximum force | 3.0 | 5.3 | 10.9 | 3.2 | 0.9 | -1.2 | 3.3 | 1.7 |
| Std. dev. time between licks in bursts | 2.9 | 3.4 | 6.5 | -1.1 | -2.5 | -1.9 | -0.6 | -2.4 |
| Cocaine response before conditioning | 2.9 | 3.6 | 8.6 | 1.4 | -1.7 | -2.9 | 1.9 | -0.9 |
| Bone: cortical thickness | 2.9 | 3.4 | 5.4 | 1.7 | 2.2 | 1.3 | 1.3 | 2.3 |
| Intermittent access intake escalation 2 | 2.8 | 2.8 | 5.1 | -1.0 | -2.3 | -1.8 | -0.4 | -2.1 |
| Cocaine induced anxiety | 2.8 | 3.2 | 4.8 | -2.2 | -1.7 | 0.0 | -2.1 | -2.0 |
| Pavlov. Cond. lever contacts | 2.8 | 3.3 | 5.8 | -1.4 | -2.4 | -1.4 | -1.1 | -2.4 |
| Run reversals in cocaine runway, males | 2.8 | 2.8 | 5.2 | -0.2 | -2.3 | -2.2 | 0.0 | -1.9 |
| Mg content in liver | 2.8 | 2.9 | 4.2 | -2.1 | -1.6 | -0.2 | -2.0 | -2.0 |
| Length with tail | 2.7 | 10.0 | 23.2 | 2.5 | -2.8 | -4.8 | 3.3 | -1.4 |
| Delay discounting total patch changes 6 sec | 2.7 | 4.2 | 6.9 | 1.9 | 2.6 | 1.4 | 1.4 | 2.6 |
| Pavlov. Cond. magazine entry number | 2.7 | 3.4 | 4.9 | 2.1 | 1.9 | 0.3 | 2.0 | 2.2 |
| Progressive ratio | 2.7 | 3.2 | 6.4 | 2.5 | 0.5 | -1.3 | 2.5 | 1.2 |
| Cu content in liver | 2.7 | 3.2 | 7.6 | -1.0 | 1.9 | 2.8 | -1.5 | 1.2 |
| Soleus weight | 2.6 | 7.6 | 15.3 | -1.1 | -3.9 | -3.0 | -0.4 | -3.5 |
| Median of all reaction times | 2.6 | 3.5 | 5.9 | -1.6 | -2.4 | -1.2 | -1.3 | -2.4 |
| Time in familiar zone, hab. session 1 | 2.6 | 2.4 | 5.5 | -0.7 | 1.8 | 2.3 | -1.2 | 1.2 |
| Bone: maximum moment | 2.6 | 4.6 | 9.8 | 3.0 | 0.6 | -1.2 | 3.1 | 1.5 |
| Bone: tissue strength | 2.6 | 2.5 | 5.3 | 2.2 | 0.7 | -0.6 | 2.3 | 1.3 |
| Total resting periods, locomotor time 2 | 2.6 | 2.8 | 5.1 | -0.5 | -2.3 | -2.1 | -0.1 | -2.0 |
| Locomotor activity | 2.5 | 4.0 | 7.6 | -0.0 | -2.7 | -2.7 | 0.4 | -2.2 |
| Seeking ratio, punishment vs. effort | 2.4 | 2.9 | 6.1 | -2.4 | -0.4 | 1.2 | -2.5 | -1.1 |
| Locomotion velocity, session 7 | 2.3 | 2.5 | 5.3 | -2.1 | -0.2 | 1.4 | -2.3 | -0.9 |
| Pavlov. Cond. intertrial magazine entries | 2.2 | 2.9 | 4.0 | -2.0 | -1.7 | -0.6 | -1.7 | -2.0 |
| Delay discounting total patch changes 0 sec | 2.1 | 3.4 | 5.3 | 1.8 | 2.2 | 1.4 | 1.4 | 2.3 |
| Delay discounting total patch changes 12 sec | 2.1 | 2.9 | 4.5 | 1.7 | 2.0 | 0.9 | 1.5 | 2.1 |
| Bone: periosteal estimation | 2.1 | 4.2 | 10.0 | 1.2 | -2.2 | -3.2 | 1.8 | -1.4 |
| Bone: trabecular spacing | 2.1 | 2.7 | 5.5 | 1.6 | -1.0 | -2.3 | 2.0 | -0.3 |
| Distance moved, locomotor task time 2 | 2.1 | 2.4 | 3.9 | 1.4 | 1.9 | 0.9 | 1.3 | 2.0 |
| Co content in liver | 2.1 | 2.5 | 3.6 | 1.9 | 1.6 | 0.4 | 1.6 | 1.9 |
| Tibia length | 2.0 | 5.6 | 13.2 | 1.2 | -2.6 | -3.6 | 1.9 | -1.7 |
| Compulsive drug intake | 2.0 | 2.0 | 4.1 | -1.9 | -0.4 | 1.2 | -2.0 | -1.0 |
| Bone: minimum diameter | 2.0 | 3.7 | 7.4 | -0.4 | -2.7 | -2.4 | 0.2 | -2.3 |
| BMI without tail | 1.9 | 3.9 | 7.9 | 2.5 | -0.1 | -2.2 | 2.8 | 0.7 |
| Locomotion distance, session 7 | 1.9 | 2.5 | 4.7 | -2.0 | 0.5 | 1.9 | -2.2 | -0.2 |
| Bouts of movement, locomotor time 2 | 1.9 | 2.1 | 4.1 | -0.1 | -1.9 | -2.0 | 0.2 | -1.6 |
| Weight adjusted by age | 1.9 | 2.1 | 4.1 | 1.6 | -0.7 | -2.0 | 1.8 | -0.0 |
| Left kidney weight | 1.8 | 5.2 | 11.3 | 3.0 | -0.2 | -2.3 | 3.4 | 0.8 |
| Mean num. licks in bursts | 1.8 | 2.2 | 3.9 | 0.7 | 2.0 | 1.7 | 0.5 | 1.8 |
| Intermittent access standard deviation | 1.8 | 1.9 | 3.6 | 1.7 | 0.8 | -0.6 | 1.9 | 1.3 |
| Time in novel zone, hab. session 1 | 1.8 | 1.8 | 3.8 | 0.3 | -1.7 | -2.0 | 0.7 | -1.3 |
| Bone: cortical apparent density | 1.8 | 2.4 | 4.0 | 1.5 | 1.9 | 0.7 | 1.2 | 2.0 |
| Diff in mean of infusions in LGA sessions | 1.8 | 2.1 | 3.9 | -1.6 | 0.7 | 2.0 | -1.8 | 0.1 |
| Times rat made contact with spout | 1.7 | 2.0 | 4.6 | -0.2 | 1.7 | 2.2 | -0.6 | 1.3 |
| Saline control response | 1.7 | 2.3 | 3.4 | 1.8 | 1.6 | 0.3 | 1.6 | 1.8 |
| Intermitt. access escalation Index | 1.7 | 1.5 | 3.2 | -1.7 | -0.1 | 1.0 | -1.8 | -0.7 |
| Incentive salience index mean | 1.7 | 2.1 | 3.1 | -1.8 | -1.3 | -0.2 | -1.7 | -1.6 |
| Time to tail flick, vehicle, after self-admin | 1.7 | 1.8 | 2.8 | -1.4 | -1.5 | -0.7 | -1.2 | -1.7 |
| Delay disc. indifference point, 4s delay | 1.7 | 1.8 | 4.1 | 1.3 | -0.6 | -2.0 | 1.6 | -0.0 |
| Right kidney weight | 1.6 | 4.7 | 8.9 | 2.2 | -1.3 | -3.0 | 2.8 | -0.3 |
| Length without tail | 1.6 | 3.5 | 6.2 | 2.0 | -1.1 | -2.5 | 2.4 | -0.3 |
| Indifference point 0 sec | 1.6 | 2.6 | 4.0 | 1.5 | 1.9 | 1.3 | 1.1 | 2.0 |
| Reaction time premature initiations | 1.6 | 2.3 | 3.5 | 1.9 | 1.3 | -0.0 | 1.8 | 1.7 |
| Pavlov. Cond. change in total contacts | 1.6 | 1.7 | 3.2 | -0.2 | -1.8 | -1.7 | 0.1 | -1.5 |
| Bone: maximum diameter | 1.6 | 2.9 | 5.9 | -0.3 | -2.4 | -2.1 | 0.2 | -2.0 |
| Condit. Reinf. active-inactive response ratio | 1.5 | 1.5 | 3.3 | 1.2 | -0.9 | -1.8 | 1.5 | -0.3 |
| Short access day 1 locomotion | 1.5 | 1.6 | 3.6 | -1.7 | -0.2 | 1.0 | -1.9 | -0.8 |
| Pavlov. Cond. intertrial magazine entries | 1.5 | 1.8 | 3.6 | 0.3 | 1.9 | 1.7 | -0.0 | 1.6 |
| Bone: cortical tissue density | 1.5 | 1.9 | 3.2 | 1.4 | 1.7 | 0.6 | 1.1 | 1.8 |
| Bone: periosteal perimeter | 1.5 | 2.5 | 5.2 | 0.3 | -2.0 | -2.3 | 0.7 | -1.5 |
| Time to tail flick, test, after self-admin | 1.5 | 1.6 | 2.1 | -1.5 | -1.2 | -0.7 | -1.2 | -1.4 |
| Area under the delay curve | 1.5 | 1.6 | 2.8 | 1.7 | 0.7 | -0.8 | 1.7 | 1.1 |
| Rest time, locomotor task time 1 | 1.5 | 1.6 | 2.7 | -0.6 | -1.6 | -1.6 | -0.4 | -1.5 |
| Conditioned reinforcement - inactives | 1.4 | 1.6 | 3.2 | 1.8 | 1.1 | 0.1 | 1.4 | 1.4 |
| Bone: connectivity density | 1.4 | 2.2 | 4.3 | -1.9 | 0.2 | 1.8 | -2.1 | -0.4 |
| Bone: post-yield work | 1.4 | 1.9 | 3.6 | -0.9 | -1.9 | -1.2 | -0.6 | -1.8 |
| Delay discount exponential model param | 1.4 | 1.5 | 2.7 | -1.6 | -0.7 | 0.7 | -1.7 | -1.1 |
| Parametrial fat weight | 1.3 | 2.5 | 4.8 | 2.1 | 0.6 | -1.1 | 2.2 | 1.2 |
| Short access day 10 total locomotion | 1.3 | 1.4 | 2.6 | -0.5 | -1.6 | -1.5 | -0.2 | -1.4 |
| Stereotopy head waving duration, day 7 | 1.3 | 1.6 | 3.1 | 1.6 | -0.4 | -1.5 | 1.8 | 0.2 |
| Delay discount hyperbolic model param | 1.3 | 1.4 | 2.6 | -1.5 | -0.4 | 1.0 | -1.6 | -0.9 |
| Post-drug Anxiety | 1.2 | 1.4 | 2.1 | -1.5 | -1.1 | 0.0 | -1.3 | -1.3 |
| Short access day 1 total inactive lever presses | 1.2 | 1.3 | 3.0 | -0.5 | -1.7 | -1.0 | -0.2 | -1.6 |
| Bone: elastic work | 1.2 | 1.6 | 3.2 | 1.8 | 0.7 | -0.4 | 1.8 | 1.1 |
| Bouts of movement, locomotor time 1 | 1.2 | 1.3 | 1.9 | -1.4 | -1.1 | -0.2 | -1.3 | -1.3 |
| Run reversals in cocaine runway, females | 1.2 | 1.2 | 1.9 | 0.9 | 1.4 | 1.1 | 0.6 | 1.4 |
| Latency to leave start box in cocaine runway, M | 1.2 | 1.1 | 2.1 | 1.2 | 0.8 | -0.6 | 1.4 | 1.1 |
| BMI with tail | 1.1 | 3.6 | 7.6 | 2.5 | 0.9 | -1.0 | 2.8 | 1.5 |
| Indifference point AUC | 1.1 | 1.3 | 2.6 | 1.4 | -0.2 | -1.4 | 1.6 | 0.3 |
| Reaction time number correct | 1.1 | 1.6 | 3.0 | 0.8 | 1.7 | 1.0 | 0.7 | 1.7 |
| Reaction time trials correct on left | 1.1 | 1.6 | 3.0 | 0.8 | 1.7 | 1.0 | 0.7 | 1.7 |
| Intermitt. access day 15 inactive lever presses | 1.1 | 1.2 | 2.8 | 1.6 | 0.2 | -0.5 | 1.7 | 0.7 |
| Intermittent access day 15 total locomotion | 1.1 | 1.2 | 3.4 | 0.5 | -1.1 | -1.8 | 0.7 | -0.7 |
| Stereotopy head waving bouts, day 3 | 1.1 | 1.3 | 2.8 | 0.6 | -1.3 | -1.7 | 1.0 | -0.8 |
| Condit. Reinf. inactive responses | 1.1 | 1.4 | 3.0 | -1.1 | 0.8 | 1.7 | -1.4 | 0.3 |
| Locomotion velocity, NPP test | 1.1 | 1.6 | 3.8 | -1.1 | 0.9 | 1.9 | -1.4 | 0.4 |
| Bone: cortical area | 1.1 | 1.7 | 3.8 | 1.8 | 0.0 | -1.1 | 1.9 | 0.6 |
| Bone: stiffness | 1.1 | 1.7 | 3.0 | 1.7 | 1.0 | -0.0 | 1.7 | 1.4 |
| Bone: trabecular number | 1.1 | 1.8 | 4.3 | -0.7 | 1.4 | 2.1 | -1.1 | 0.9 |
| Bone: trabecular tissue density | 1.1 | 1.5 | 3.1 | 1.7 | 0.3 | -1.0 | 1.8 | 0.8 |
| Delay disc. indifference point, 2s delay | 1.1 | 1.2 | 2.7 | 1.2 | -0.4 | -1.6 | 1.4 | 0.0 |
| Time >=10cm from walls, locomotor time 1 | 1.1 | 1.1 | 2.2 | 0.0 | -1.4 | -1.5 | 0.2 | -1.1 |
| Liver weight, left | 1.0 | 1.6 | 3.1 | 0.1 | -1.7 | -1.7 | 0.3 | -1.4 |
| Reaction time trials on left | 1.0 | 1.4 | 2.6 | 0.8 | 1.6 | 0.9 | 0.7 | 1.6 |
| Reaction time trials completed | 1.0 | 1.4 | 2.6 | 0.8 | 1.6 | 0.9 | 0.7 | 1.6 |
| Reaction time trials AUC | 1.0 | 1.4 | 2.7 | 0.7 | 1.6 | 1.0 | 0.6 | 1.6 |
| Bone: apparent density | 1.0 | 1.7 | 4.4 | -0.9 | 1.2 | 2.1 | -1.2 | 0.7 |
| Total resting periods, locomotor time 1 | 1.0 | 1.1 | 1.7 | -1.1 | -1.2 | -0.6 | -0.9 | -1.3 |
| Cd content in liver | 1.0 | 1.1 | 1.7 | 1.1 | 1.2 | 0.4 | 1.0 | 1.3 |
| Number of licking bursts | 0.9 | 1.1 | 1.7 | -0.9 | -1.2 | -0.7 | -0.9 | -1.3 |
| Food consumed during 24 hour testing period | 0.9 | 1.1 | 2.2 | 0.2 | -1.4 | -1.5 | 0.5 | -1.0 |
| Progressive ratio test 1 inactive lever presses | 0.9 | 0.9 | 1.6 | 0.7 | 1.3 | 1.1 | 0.2 | 1.1 |
| Stereotopy head waving bouts, day 7 | 0.9 | 1.1 | 2.4 | 1.4 | -0.1 | -1.0 | 1.5 | 0.4 |
| Time in closed arm after self-admin | 0.9 | 0.9 | 1.3 | 1.1 | 0.9 | -0.2 | 1.1 | 1.1 |
| Delay discounting water rate 24 sec | 0.8 | 1.1 | 2.6 | 1.3 | 0.4 | -0.5 | 1.6 | 0.8 |
| Locomotor testing rearing | 0.8 | 1.2 | 2.4 | 0.2 | -1.5 | -1.5 | 0.4 | -1.1 |
| Intermittent access total locomotion | 0.8 | 0.9 | 2.5 | 0.4 | -1.0 | -1.6 | 0.5 | -0.7 |
| Locomotion distance, session 3 | 0.8 | 0.9 | 1.6 | -1.1 | 0.3 | 1.2 | -1.2 | -0.1 |
| Bone: trabecular thickness | 0.8 | 1.0 | 2.5 | -0.7 | 0.9 | 1.6 | -0.9 | 0.5 |
| Distance moved, locomotor task time 1 | 0.8 | 0.9 | 1.2 | 1.0 | 0.9 | 0.4 | 1.1 | 1.1 |
| Vertical activity count, locomotor time 2 | 0.8 | 0.8 | 1.6 | 0.6 | 1.3 | 0.8 | 0.5 | 1.2 |
| Fe content in liver | 0.8 | 1.0 | 1.5 | 1.0 | 1.1 | 0.4 | 0.9 | 1.2 |
| Sr content in liver | 0.8 | 0.7 | 1.8 | 0.3 | -1.0 | -1.3 | 0.5 | -0.7 |
| Delay discounting time to switch 0 sec | 0.7 | 1.1 | 2.0 | 0.2 | 1.4 | 1.4 | -0.3 | 1.1 |
| Reaction time premature initiation rate | 0.7 | 1.0 | 2.1 | 1.4 | 0.4 | -0.5 | 1.4 | 0.8 |
| Condit. Reinf. active minus inactive responses | 0.7 | 0.8 | 1.5 | 1.0 | -0.4 | -1.2 | 1.2 | 0.0 |
| Condit. Reinf. inactive responses | 0.7 | 0.9 | 1.9 | -1.2 | 0.2 | 1.0 | -1.4 | -0.2 |
| Baseline Anxiety | 0.7 | 0.8 | 1.5 | 0.5 | 1.2 | 0.8 | 0.4 | 1.2 |
| Locomotion distance, session 1 | 0.7 | 0.9 | 2.2 | 0.1 | 1.2 | 1.5 | -0.3 | 1.0 |
| Stereotopy head waving duration, day 3 | 0.7 | 0.9 | 2.0 | 0.7 | -0.9 | -1.4 | 1.0 | -0.5 |
| Degree of sensitization distance | 0.7 | 0.7 | 1.1 | -0.9 | -0.9 | -0.5 | -0.8 | -1.0 |
| Total locomotion distance, NPP test | 0.7 | 1.0 | 2.3 | -0.8 | 0.8 | 1.5 | -1.0 | 0.4 |
| Time in open arm before self-admin | 0.7 | 0.8 | 1.3 | -0.7 | -1.1 | -0.6 | -0.7 | -1.2 |
| Time in open arm after self-admin | 0.7 | 0.8 | 1.3 | -0.9 | -0.8 | 0.1 | -1.1 | -1.0 |
| Delta time to tail flick, test, before/after SA | 0.7 | 0.6 | 1.5 | -1.2 | -0.3 | 0.3 | -1.0 | -0.6 |
| Delay disc. indifference point, 24s delay | 0.7 | 0.7 | 1.0 | 1.0 | 0.8 | -0.0 | 1.0 | 1.0 |
| Indifference point function ln k | 0.6 | 0.8 | 1.3 | -1.1 | -0.9 | 0.0 | -1.0 | -1.0 |
| Indifference point function log k | 0.6 | 0.8 | 1.3 | -1.1 | -0.9 | 0.0 | -1.0 | -1.0 |
| Light reinforcement 2 | 0.6 | 0.8 | 2.4 | 0.4 | -0.7 | -1.6 | 0.8 | -0.4 |
| Reaction time false alarm rate | 0.6 | 0.9 | 1.9 | 0.0 | -1.4 | -1.1 | 0.4 | -1.1 |
| Degree of sensitization stereotypy | 0.6 | 0.7 | 1.5 | 1.1 | 0.1 | -0.6 | 1.2 | 0.4 |
| Condit. Reinf. active responses | 0.6 | 0.7 | 1.6 | -1.1 | 0.1 | 0.8 | -1.3 | -0.3 |
| Total locomotion distance, hab. session 2 | 0.6 | 0.8 | 1.7 | -0.8 | 0.6 | 1.3 | -1.0 | 0.2 |
| Locomotion velocity, hab. session 2 | 0.6 | 0.8 | 1.8 | -0.9 | 0.5 | 1.3 | -1.1 | 0.1 |
| Total zone transitions, NPP test | 0.6 | 0.8 | 1.6 | -1.1 | 0.1 | 1.1 | -1.3 | -0.3 |
| Bone: cortical porosity | 0.6 | 0.6 | 1.0 | 1.0 | 0.7 | 0.2 | 0.9 | 0.9 |
| Breakpoint value in progressive ratio session | 0.6 | 0.6 | 1.2 | -1.0 | 0.0 | 0.8 | -1.1 | -0.3 |
| Distance traveled before self-admin | 0.6 | 0.6 | 1.1 | -0.6 | -1.1 | -0.7 | -0.4 | -1.0 |
| Delta distance traveled before/after self-admin | 0.6 | 0.6 | 1.5 | 1.1 | 0.1 | -0.4 | 1.2 | 0.4 |
| Vertical activity count, locomotor time 1 | 0.6 | 0.6 | 0.9 | 0.7 | 0.9 | 0.5 | 0.8 | 0.9 |
| Time >=10cm from walls, locomotor time 2 | 0.6 | 0.6 | 1.0 | -0.4 | -1.0 | -1.0 | -0.2 | -0.9 |
| Tibialis anterior weight | 0.5 | 1.8 | 3.1 | 0.8 | 1.8 | 1.6 | 0.6 | 1.6 |
| Conditioned locomotion | 0.5 | 0.6 | 1.9 | 0.5 | -0.7 | -1.4 | 0.7 | -0.4 |
| Intermittent access intake escalation | 0.5 | 0.5 | 1.3 | 0.0 | -0.8 | -1.2 | 0.4 | -0.6 |
| Progressive ratio test 2 breakpoint | 0.5 | 0.6 | 1.1 | -0.6 | 0.8 | 1.0 | -0.9 | 0.4 |
| One hour access (shock baseline) | 0.5 | 0.6 | 1.6 | 0.8 | -0.4 | -1.3 | 0.7 | -0.1 |
| Locomotion velocity, session 3 | 0.5 | 0.5 | 0.9 | 0.6 | 1.0 | 0.6 | 0.4 | 1.0 |
| Bone: elastic displacement | 0.5 | 0.6 | 1.0 | 0.7 | 1.0 | 0.5 | 0.6 | 1.0 |
| Extinction: sum of active levers before priming | 0.5 | 0.5 | 1.3 | -0.3 | 0.6 | 1.1 | -0.7 | 0.3 |
| Fecal boli incidents, locomotor time 1 | 0.5 | 0.5 | 1.0 | -0.9 | -0.0 | 0.8 | -1.0 | -0.4 |
| Locomotion in novel chamber post-restriction | 0.5 | 0.6 | 1.1 | 1.0 | 0.5 | -0.2 | 1.0 | 0.8 |
| Rb content in liver | 0.5 | 0.6 | 1.3 | -1.0 | 0.1 | 0.9 | -1.1 | -0.3 |
| Intraocular pressure | 0.4 | 0.6 | 1.4 | -1.0 | 0.1 | 0.8 | -1.2 | -0.3 |
| Delay discounting water rate 12 sec | 0.4 | 0.6 | 1.1 | 0.2 | 1.1 | 0.9 | -0.0 | 1.0 |
| Locomotor testing distance | 0.4 | 0.7 | 1.6 | -0.1 | -1.3 | -0.9 | 0.0 | -1.1 |
| Light reinforcement 1 | 0.4 | 0.8 | 1.4 | 0.6 | 1.2 | 0.6 | 0.7 | 1.2 |
| Social response proportion | 0.4 | 0.4 | 0.9 | -0.1 | -0.9 | -0.8 | -0.1 | -0.8 |
| Cocaine response after cond. not corrected | 0.4 | 0.5 | 1.0 | -0.1 | -0.9 | -1.0 | 0.0 | -0.8 |
| Pavlov. Cond. lever contacts | 0.4 | 0.5 | 0.9 | 0.2 | 1.0 | 0.9 | -0.1 | 0.8 |
| Intermittent access intake day 1-15 change | 0.4 | 0.4 | 0.8 | 0.6 | 0.1 | -0.7 | 0.9 | 0.3 |
| Incentive Sensitization - Responses | 0.4 | 0.4 | 0.7 | -0.7 | 0.4 | 0.8 | -0.7 | 0.1 |
| Incentive Sensitization - Breakpoint | 0.4 | 0.4 | 0.8 | -0.9 | 0.3 | 0.8 | -0.8 | -0.0 |
| Locomotion velocity, session 1 | 0.4 | 0.4 | 0.7 | -0.7 | -0.8 | -0.3 | -0.6 | -0.8 |
| Condit. Reinf. active minus inactive responses | 0.4 | 0.4 | 1.0 | -0.9 | -0.2 | 0.3 | -1.0 | -0.4 |
| Distance traveled after self-admin | 0.4 | 0.4 | 0.9 | -0.1 | -1.0 | -0.7 | 0.3 | -0.8 |
| Active lever presses in extinction session 6 | 0.4 | 0.4 | 0.9 | 0.2 | 0.9 | 0.7 | 0.2 | 0.8 |
| Delta time to tail flick, vehicle, before/after SA | 0.4 | 0.4 | 0.9 | -0.9 | -0.2 | 0.2 | -0.9 | -0.5 |
| Locomotion in novel chamber | 0.4 | 0.4 | 1.0 | 0.9 | -0.0 | -0.5 | 1.0 | 0.3 |
| Delay discounting water rate 6 sec | 0.3 | 0.5 | 0.9 | 0.3 | 0.9 | 0.7 | 0.3 | 0.9 |
| Reaction time num false alarms AUC | 0.3 | 0.4 | 0.9 | 0.7 | -0.4 | -0.6 | 1.0 | -0.1 |
| Pavlov. Cond. magazine entry latency | 0.3 | 0.4 | 0.9 | 0.5 | -0.5 | -1.0 | 0.7 | -0.3 |
| Pavlov. Cond. change in total contacts | 0.3 | 0.4 | 0.6 | 0.7 | 0.7 | 0.1 | 0.6 | 0.8 |
| Conditioned reinforcement - actives | 0.3 | 0.3 | 0.8 | 0.9 | 0.3 | -0.3 | 0.7 | 0.5 |
| Intermitt. access day 1 inactive lever presses | 0.3 | 0.3 | 0.9 | -0.2 | -0.9 | -0.4 | 0.1 | -0.8 |
| Intermittent access day 1 total infusions | 0.3 | 0.3 | 0.6 | -0.0 | 0.6 | 0.8 | -0.6 | 0.3 |
| Intermittent access day 1 locomotion | 0.3 | 0.3 | 0.4 | -0.3 | -0.6 | -0.5 | -0.6 | -0.7 |
| Progressive ratio test 2 active lever presses | 0.3 | 0.3 | 0.5 | -0.3 | 0.6 | 0.7 | -0.7 | 0.3 |
| Short access day 10 total inactive lever presses | 0.3 | 0.4 | 0.8 | -0.5 | -0.9 | -0.0 | -0.2 | -0.9 |
| Total zone transitions, hab. session 1 | 0.3 | 0.5 | 1.0 | -0.7 | 0.2 | 1.0 | -0.9 | -0.1 |
| Total locomotion distance, hab. session 1 | 0.3 | 0.4 | 1.1 | -0.6 | 0.5 | 1.0 | -0.7 | 0.2 |
| Locomotion velocity, hab. session 1 | 0.3 | 0.4 | 1.0 | -0.2 | 0.7 | 1.0 | -0.3 | 0.5 |
| Time in familiar zone, hab. session 2 | 0.3 | 0.3 | 0.8 | -0.1 | 0.7 | 0.9 | -0.3 | 0.5 |
| Bone: cortical porosity | 0.3 | 0.3 | 0.5 | 0.6 | -0.3 | -0.7 | 0.7 | -0.1 |
| Sum of active levers in priming session hrs 5-6 | 0.3 | 0.2 | 0.4 | -0.6 | 0.3 | 0.6 | -0.6 | 0.1 |
| Time to tail flick, vehicle, before self-admin | 0.3 | 0.3 | 0.6 | -0.5 | -0.7 | -0.3 | -0.5 | -0.8 |
| Ambulatory time after self-admin | 0.3 | 0.4 | 0.9 | -0.2 | -0.9 | -0.5 | 0.2 | -0.8 |
| Delay disc. indifference point, 0s delay | 0.3 | 0.4 | 1.1 | 0.4 | -0.5 | -1.1 | 0.5 | -0.2 |
| Delay disc. indifference point, 8s delay | 0.3 | 0.3 | 0.6 | 0.8 | 0.4 | -0.2 | 0.7 | 0.5 |
| Change in fecal boli incidents, locomotor task | 0.3 | 0.3 | 0.8 | 0.4 | -0.3 | -0.9 | 0.7 | -0.0 |
| Retroperitoneal fat weight | 0.2 | 0.8 | 1.6 | 1.2 | 0.3 | -0.5 | 1.3 | 0.7 |
| Extensor digitorum longus weight | 0.2 | 0.8 | 1.8 | -0.4 | -1.3 | -0.9 | -0.1 | -1.2 |
| Delay discounting water rate 0 sec | 0.2 | 0.4 | 0.8 | 0.8 | 0.3 | -0.2 | 0.9 | 0.6 |
| Reaction time num false alarms | 0.2 | 0.2 | 0.6 | 0.4 | -0.4 | -0.5 | 0.8 | -0.2 |
| Cocaine response after cond. corrected | 0.2 | 0.2 | 0.5 | -0.5 | 0.3 | 0.6 | -0.7 | 0.0 |
| Condit. Reinf. lever presses | 0.2 | 0.3 | 0.6 | -0.7 | 0.1 | 0.8 | -0.8 | -0.2 |
| Pavlov. Cond. magazine entry number | 0.2 | 0.2 | 0.4 | -0.6 | -0.0 | 0.5 | -0.6 | -0.2 |
| Progressive ratio test 2 inactive lever presses | 0.2 | 0.2 | 0.5 | 0.7 | -0.2 | -0.6 | 0.5 | 0.0 |
| Short access day 10 total infusions | 0.2 | 0.2 | 0.6 | 0.8 | 0.3 | -0.1 | 0.4 | 0.4 |
| Short access total locomotion | 0.2 | 0.2 | 0.4 | -0.3 | -0.6 | -0.4 | -0.5 | -0.6 |
| One hour access (0.3 mA shock) | 0.2 | 0.3 | 0.8 | -0.5 | -0.0 | 0.4 | -0.9 | -0.3 |
| Number of responses in last shaping day | 0.2 | 0.2 | 0.3 | 0.5 | -0.3 | -0.4 | 0.5 | -0.2 |
| Locomotion velocity, session 2 | 0.2 | 0.2 | 0.3 | -0.3 | -0.6 | -0.5 | -0.2 | -0.6 |
| Locomotion distance, session 2 | 0.2 | 0.3 | 0.7 | -0.4 | 0.3 | 0.9 | -0.6 | 0.1 |
| Condit. Reinf. active-inactive response ratio | 0.2 | 0.2 | 0.4 | 0.3 | 0.6 | 0.2 | 0.2 | 0.6 |
| Time in novel zone, hab. session 2 | 0.2 | 0.2 | 0.4 | 0.4 | -0.2 | -0.6 | 0.5 | -0.0 |
| Total zone transitions, hab. session 2 | 0.2 | 0.3 | 0.5 | 0.4 | 0.7 | 0.6 | 0.1 | 0.7 |
| Novel to familiar place preference ratio | 0.2 | 0.2 | 0.4 | 0.3 | 0.6 | 0.4 | 0.2 | 0.6 |
| Novelty place preference | 0.2 | 0.2 | 0.2 | 0.5 | 0.4 | 0.1 | 0.4 | 0.5 |
| Time in novel zone, NPP test | 0.2 | 0.2 | 0.3 | 0.5 | 0.3 | -0.2 | 0.5 | 0.4 |
| Delta ambulatory time before/after self-admin | 0.2 | 0.2 | 0.4 | 0.4 | -0.5 | -0.6 | 0.6 | -0.3 |
| Time to tail flick, test, before self-admin | 0.2 | 0.2 | 0.4 | 0.5 | 0.6 | 0.0 | 0.2 | 0.7 |
| Seeking ratio, delayed vs. immediate footshock | 0.2 | 0.2 | 0.5 | 0.7 | -0.1 | -0.6 | 0.6 | 0.1 |
| Latency to leave start box in cocaine runway, F | 0.2 | 0.2 | 0.4 | -0.6 | -0.2 | 0.2 | -0.5 | -0.4 |
| Na content in liver | 0.2 | 0.2 | 0.4 | 0.5 | 0.6 | 0.4 | 0.3 | 0.6 |
| Heart weight | 0.1 | 0.1 | 0.3 | 0.2 | -0.3 | -0.5 | 0.3 | -0.1 |
| Water consumed over 24 hours | 0.1 | 0.2 | 0.3 | -0.2 | -0.5 | -0.4 | -0.2 | -0.5 |
| Delay discounting water rate 18 sec | 0.1 | 0.2 | 0.3 | 0.5 | -0.2 | -0.6 | 0.5 | -0.0 |
| Social responses | 0.1 | 0.1 | 0.4 | 0.3 | -0.2 | -0.6 | 0.3 | -0.1 |
| Condit. Reinf. lever reinforcers received | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.1 | -0.3 | -0.3 |
| Pavlov. Cond. lever latency | 0.1 | 0.2 | 0.4 | 0.4 | -0.3 | -0.6 | 0.5 | -0.2 |
| Conditioned locomotion | 0.1 | 0.1 | 0.2 | 0.1 | -0.3 | -0.4 | 0.0 | -0.3 |
| Intermittent access terminal intake (last 3 days) | 0.1 | 0.1 | 0.2 | 0.5 | 0.4 | -0.1 | 0.3 | 0.4 |
| Intermittent access total infusions | 0.1 | 0.1 | 0.3 | 0.4 | 0.5 | 0.2 | 0.1 | 0.5 |
| Lifetime Intake | 0.1 | 0.1 | 0.2 | 0.4 | 0.4 | 0.1 | 0.1 | 0.4 |
| Progressive ratio test 1 active lever presses | 0.1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.1 | -0.4 | 0.2 |
| Progressive ratio test 1 breakpoint | 0.1 | 0.1 | 0.2 | 0.2 | 0.4 | 0.3 | -0.3 | 0.3 |
| Total sessions with >9 infusions | 0.1 | 0.1 | 0.3 | 0.6 | 0.2 | -0.2 | 0.3 | 0.2 |
| Short access day 1 total infusions | 0.1 | 0.1 | 0.2 | -0.4 | -0.0 | 0.4 | -0.5 | -0.2 |
| Short access total infusions | 0.1 | 0.1 | 0.4 | 0.6 | 0.3 | -0.1 | 0.3 | 0.4 |
| Bone surface | 0.1 | 0.2 | 0.3 | 0.1 | -0.6 | -0.6 | 0.3 | -0.4 |
| Bone volume | 0.1 | 0.2 | 0.2 | 0.4 | 0.4 | 0.3 | 0.4 | 0.5 |
| Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 0.2 | 0.4 | 0.0 | -0.1 | 0.4 | 0.1 |
| Ambulatory time before self-admin | 0.1 | 0.1 | 0.1 | -0.1 | -0.4 | -0.3 | 0.0 | -0.3 |
| K content in liver | 0.1 | 0.1 | 0.3 | -0.3 | 0.1 | 0.6 | -0.4 | -0.1 |
| Zn content in liver | 0.1 | 0.1 | 0.1 | -0.2 | -0.3 | 0.2 | -0.2 | -0.3 |
| Condit. Reinf. active responses | 0.0 | 0.0 | 0.0 | -0.1 | -0.2 | -0.2 | -0.0 | -0.1 |
| Pavlov. Cond. index score | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | -0.1 | 0.1 | 0.0 |
| Pavlov. Cond. latency score | 0.0 | 0.1 | 0.1 | 0.3 | 0.1 | -0.1 | 0.3 | 0.2 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | -0.1 | 0.1 | 0.0 |
| Pavlov. Cond. response bias | 0.0 | 0.1 | 0.1 | -0.1 | 0.3 | 0.4 | -0.2 | 0.2 |
| Intermittent access day 15 total infusions | 0.0 | 0.1 | 0.1 | 0.1 | 0.4 | 0.1 | -0.1 | 0.3 |
| Delta time in open arm before/after self-admin | 0.0 | 0.0 | 0.1 | 0.3 | 0.2 | 0.2 | 0.1 | 0.3 |
| Time in closed arm before self-admin | 0.0 | 0.0 | 0.0 | -0.1 | 0.2 | -0.1 | -0.1 | 0.1 |
| Total heroin consumption | 0.0 | 0.0 | 0.1 | -0.3 | -0.1 | 0.1 | -0.1 | -0.1 |
| Food seeking constrained by brief footshock | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.1 | -0.2 | -0.1 |
| Latency to leave start box in cocaine runway | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | -0.3 | 0.3 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.