Hub : Genes

Vom2r35

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative polyA ENSRNOT00000107882 0.27 0.13 2.3e-10 0.05 0.07 0.06 0.05 3.2e-06 5.4e-08 3.1e-07 1.4e-06
2 Adipose gene expression ENSRNOG00000050831 0.46 0.15 0.0e+00 0.18 0.19 0.19 0.18 4.4e-19 2.2e-20 1.4e-20 4.4e-20
3 PL alternative polyA ENSRNOT00000107882 0.09 0.1 6.5e-03 0.02 0.01 0.02 0.01 1.7e-02 4.3e-02 1.7e-02 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail1.03.34.31.4-1.92.1
BMI without tail1.22.65.02.2-1.01.4
Body weight0.10.50.8-0.70.9-0.5
Epididymis fat weight0.20.40.8-0.4-0.50.9
Glucose1.11.62.61.6-1.21.0
Heart weight1.01.42.40.41.6-1.3
Left kidney weight2.67.610.4-1.83.2-3.0
Right kidney weight2.16.09.0-1.73.0-2.5
Tail length0.51.52.20.91.5-1.2
Length with tail1.86.48.3-2.02.9-2.7
Length without tail1.94.16.4-2.51.7-1.7
Liver weight, left0.81.33.7-1.90.40.0
Liver weight, right0.20.30.8-0.90.10.2
Parametrial fat weight4.58.811.42.2-3.13.4
Retroperitoneal fat weight4.815.920.33.2-4.24.5
Intraocular pressure0.30.40.6-0.80.4-0.6
Extensor digitorum longus weight0.00.20.3-0.10.5-0.5
Soleus weight0.10.30.80.9-0.10.2
Tibialis anterior weight1.96.47.12.7-2.52.4
Tibia length2.26.18.0-1.72.7-2.8
Number of licking bursts0.20.20.3-0.50.6-0.2
Food consumed during 24 hour testing period0.81.01.8-0.41.4-1.0
Times rat made contact with spout0.40.40.60.8-0.70.4
Mean time between licks in bursts1.62.22.81.7-1.41.3
Mean num. licks in bursts0.50.60.80.9-0.90.4
Std. dev. time between licks in bursts0.20.20.70.80.1-0.0
Water consumed over 24 hours0.70.91.30.01.1-1.1
Indifference point 0 sec1.72.75.12.3-1.31.1
Indifference point AUC0.50.61.00.3-1.00.9
Indifference point function ln k4.36.09.1-0.73.0-2.9
Indifference point function log k4.36.09.1-0.73.0-2.9
Delay discounting total patch changes 0 sec1.72.75.22.3-1.31.1
Delay discounting total patch changes 12 sec0.91.21.90.7-1.41.1
Delay discounting total patch changes 18 sec1.62.12.71.3-1.61.4
Delay discounting total patch changes 24 sec0.30.30.7-0.8-0.40.4
Delay discounting total patch changes 6 sec0.81.31.80.7-1.21.4
Delay discounting time to switch 0 sec1.82.83.4-1.7-1.41.8
Delay discounting water rate 0 sec0.40.60.91.00.5-0.8
Delay discounting water rate 12 sec1.21.81.91.41.3-1.4
Delay discounting water rate 18 sec0.60.70.80.80.9-0.9
Delay discounting water rate 24 sec0.30.50.70.30.7-0.9
Delay discounting water rate 6 sec5.58.09.8-2.13.1-3.1
Locomotor activity0.40.60.70.8-0.90.7
Locomotor testing distance0.10.10.20.3-0.40.3
Locomotor testing rearing0.00.10.2-0.10.2-0.4
Light reinforcement 10.40.71.91.4-0.5-0.0
Light reinforcement 20.50.70.90.5-1.01.0
Reaction time number correct1.41.93.71.9-1.20.8
Reaction time mean minus median0.30.40.8-0.90.4-0.4
Reaction time mean minus median AUC0.30.41.0-1.00.2-0.3
Reaction time num false alarms0.10.10.40.60.00.1
Reaction time num false alarms AUC0.71.02.41.6-0.60.5
Reaction time trials correct on left1.41.93.71.9-1.20.8
Reaction time trials on left1.31.93.61.9-1.20.8
Reaction time mean2.94.06.5-2.51.8-1.5
Reaction time mean AUC2.02.75.1-2.31.4-1.0
Median of all reaction times2.23.04.7-2.21.6-1.3
Reaction time omissions0.00.10.10.4-0.20.2
Reaction time false alarm rate0.00.10.20.40.10.1
Reaction time premature initiation rate0.00.00.0-0.00.10.0
Reaction time premature initiations0.40.61.01.0-0.60.6
Std. dev. reaction times1.41.93.0-1.71.3-1.0
Reaction time trials completed1.31.93.61.9-1.20.8
Reaction time trials AUC1.21.83.31.8-1.20.8
Social response proportion2.62.83.7-1.91.9-1.1
Social responses5.26.77.2-2.72.7-2.4
Social time2.02.63.90.31.9-2.0
Conditioned locomotion0.10.10.40.6-0.10.1
Cocaine response after cond. corrected0.80.82.1-1.5-0.20.6
Cocaine response after cond. not corrected1.31.53.0-1.71.0-0.7
Cocaine response before conditioning2.83.45.8-0.32.1-2.4
Saline control response0.10.20.40.3-0.0-0.6
Condit. Reinf. active minus inactive responses3.23.95.6-1.22.2-2.4
Condit. Reinf. active-inactive response ratio4.54.75.5-1.72.3-2.4
Condit. Reinf. active responses2.02.84.8-0.51.8-2.2
Condit. Reinf. inactive responses0.30.41.21.1-0.2-0.1
Condit. Reinf. lever presses0.10.10.30.5-0.3-0.1
Condit. Reinf. lever reinforcers received2.43.35.8-0.71.9-2.4
Pavlov. Cond. lever latency3.64.97.4-2.72.2-1.6
Pavlov. Cond. magazine entry latency2.42.83.31.7-1.81.5
Pavlov. Cond. change in total contacts0.60.92.31.5-0.6-0.0
Pavlov. Cond. index score1.82.33.31.8-1.61.1
Pavlov. Cond. latency score2.43.04.02.0-1.81.3
Pavlov. Cond. lever contacts1.52.13.31.8-1.50.9
Pavlov. Cond. magazine entry number1.21.41.8-1.21.3-1.0
Pavlov. Cond. intertrial magazine entries4.76.06.7-2.22.6-2.5
Pavlov. Cond. lever-magazine prob. diff.1.51.92.91.7-1.40.9
Pavlov. Cond. response bias0.50.81.41.2-0.90.3
Conditioned reinforcement - actives1.41.42.5-1.61.2-0.5
Conditioned reinforcement - inactives4.55.18.5-1.32.9-2.3
Conditioned locomotion1.82.23.6-1.91.5-0.7
Intermittent access intake day 1-15 change1.61.63.1-0.61.8-1.1
Intermittent access intake escalation1.91.83.3-1.01.8-1.1
Intermittent access intake escalation 21.11.12.0-0.51.4-1.1
Intermitt. access day 1 inactive lever presses7.27.711.4-3.42.8-2.0
Intermitt. access day 15 inactive lever presses7.48.112.9-3.62.7-2.1
Intermitt. access escalation Index1.31.21.51.1-0.91.2
Intermittent access day 1 total infusions0.60.60.9-0.90.8-0.7
Intermittent access day 15 total infusions2.62.94.9-1.62.2-1.1
Intermittent access terminal intake (last 3 days)2.52.83.9-1.72.0-1.2
Intermittent access total infusions2.52.73.5-1.81.9-1.3
Intermittent access day 1 locomotion1.11.11.6-0.81.3-1.0
Intermittent access day 15 total locomotion1.21.22.7-0.31.6-0.9
Intermittent access total locomotion2.52.84.1-1.42.0-1.5
Intermittent access standard deviation1.21.22.9-1.70.9-0.2
Cocaine induced anxiety1.21.42.0-0.31.4-1.4
Post-drug Anxiety1.51.63.6-1.90.8-0.8
Baseline Anxiety1.01.12.7-1.7-0.50.5
Lifetime Intake1.01.21.7-1.11.3-0.8
Incentive Sensitization - Responses6.76.79.1-2.63.0-2.1
Incentive Sensitization - Breakpoint5.55.57.1-2.52.7-1.8
Progressive ratio test 1 active lever presses0.50.51.0-0.10.7-1.0
Progressive ratio test 1 breakpoint0.50.50.9-0.10.7-1.0
Progressive ratio test 1 inactive lever presses4.75.05.8-1.92.4-2.4
Progressive ratio test 2 active lever presses1.61.72.9-1.01.7-1.1
Progressive ratio test 2 breakpoint2.22.43.7-1.41.9-1.3
Progressive ratio test 2 inactive lever presses3.94.56.4-1.72.5-2.0
Total sessions with >9 infusions3.23.54.2-2.01.8-1.7
Short access day 1 total inactive lever presses2.83.16.1-2.51.5-0.9
Short access day 10 total inactive lever presses2.32.54.4-2.11.5-1.0
Short access day 1 total infusions0.00.00.0-0.10.1-0.1
Short access day 10 total infusions0.30.30.9-0.90.3-0.1
Short access total infusions0.40.50.60.8-0.60.7
Short access day 1 locomotion1.61.72.5-1.61.1-1.2
Short access day 10 total locomotion1.21.32.2-0.51.5-1.2
Short access total locomotion0.30.31.01.00.0-0.2
Compulsive drug intake1.51.52.0-1.01.4-1.2
One hour access (0.3 mA shock)6.17.19.0-2.63.0-2.3
One hour access (shock baseline)3.74.37.7-2.81.9-1.2
Number of responses in last shaping day1.71.73.1-1.81.3-0.7
Context. condit. distance diff. score0.50.60.91.0-0.90.4
Locomotion velocity, session 10.10.10.20.30.3-0.5
Locomotion distance, session 11.92.44.0-0.51.7-2.0
Locomotion velocity, session 20.00.10.2-0.00.1-0.4
Locomotion distance, session 22.33.34.2-1.41.9-2.0
Locomotion velocity, session 30.10.10.2-0.4-0.1-0.3
Locomotion distance, session 30.20.20.30.4-0.3-0.6
Stereotopy head waving bouts, day 30.00.00.1-0.1-0.00.4
Stereotopy head waving duration, day 30.10.10.1-0.40.40.2
Locomotion velocity, session 70.30.30.3-0.50.6-0.5
Locomotion distance, session 70.00.00.00.20.2-0.1
Stereotopy head waving bouts, day 70.50.51.0-1.00.4-0.7
Stereotopy head waving duration, day 70.40.50.7-0.90.6-0.6
Locomotion velocity, session 80.10.10.30.30.1-0.5
Locomotion distance, session 80.10.20.40.20.1-0.6
Degree of sensitization distance0.10.10.10.00.40.3
Degree of sensitization stereotypy0.10.10.2-0.5-0.3-0.4
Condit. Reinf. active minus inactive responses0.10.10.3-0.50.20.2
Condit. Reinf. active-inactive response ratio0.91.01.50.7-1.01.2
Condit. Reinf. active responses0.80.91.6-1.30.9-0.6
Condit. Reinf. inactive responses2.83.43.7-1.61.9-1.9
Incentive salience index mean0.30.40.6-0.60.8-0.4
Condit. Reinf. lever presses0.50.61.2-0.21.1-0.8
Time in familiar zone, hab. session 11.11.11.50.71.1-1.2
Time in novel zone, hab. session 10.80.81.4-1.2-0.60.7
Total zone transitions, hab. session 10.71.02.0-0.40.9-1.4
Total locomotion distance, hab. session 10.30.41.01.00.1-0.4
Locomotion velocity, hab. session 10.10.20.50.70.1-0.4
Time in familiar zone, hab. session 22.72.83.2-1.71.8-1.5
Time in novel zone, hab. session 20.80.81.40.5-1.20.9
Total zone transitions, hab. session 20.91.22.5-0.11.0-1.6
Total locomotion distance, hab. session 20.70.92.41.6-0.50.2
Locomotion velocity, hab. session 21.01.33.31.8-0.70.3
Novel to familiar place preference ratio0.50.51.01.0-0.60.4
Novelty place preference0.10.10.40.6-0.20.1
Time in novel zone, NPP test0.10.10.20.5-0.1-0.0
Total zone transitions, NPP test0.10.10.20.50.1-0.3
Total locomotion distance, NPP test0.40.51.41.2-0.30.2
Locomotion velocity, NPP test0.40.61.71.3-0.30.2
Pavlov. Cond. lever latency0.00.00.1-0.30.10.1
Pavlov. Cond. magazine entry latency0.70.91.20.8-1.11.0
Pavlov. Cond. change in total contacts0.20.30.40.7-0.40.4
Pavlov. Cond. index score0.40.50.70.8-0.70.6
Pavlov. Cond. latency score0.40.50.80.9-0.70.6
Pavlov. Cond. lever contacts0.00.00.0-0.00.00.0
Pavlov. Cond. magazine entry number0.60.70.8-0.90.9-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.10.40.2-0.3
Pavlov. Cond. lever-magazine prob. diff.0.40.50.60.7-0.70.6
Pavlov. Cond. response bias0.10.10.20.0-0.40.3
Bone: apparent density0.00.00.10.3-0.1-0.2
Bone surface2.64.65.6-1.72.3-2.4
Bone volume2.23.74.4-1.72.0-2.1
Bone: connectivity density0.20.30.50.5-0.70.2
Bone: cortical apparent density0.30.40.6-0.80.7-0.0
Bone: cortical area0.20.30.40.20.6-0.7
Bone: cortical porosity0.50.61.00.0-1.00.9
Bone: cortical porosity0.30.30.5-0.2-0.70.6
Bone: cortical thickness0.71.21.61.2-1.01.0
Bone: cortical thickness0.10.20.4-0.10.6-0.4
Bone: cortical tissue density0.30.40.8-0.90.7-0.1
Bone: elastic displacement1.11.21.91.4-0.91.0
Bone: elastic work0.50.61.81.30.0-0.0
Bone: endosteal estimation2.24.85.9-1.82.3-2.4
Bone: endosteal perimeter1.43.03.9-1.12.0-2.0
Bone: final force1.32.22.8-1.11.7-1.6
Bone: final moment1.52.43.3-1.01.8-1.7
Bone: marrow area2.24.85.9-1.82.3-2.4
Bone: maximum diameter0.40.81.2-0.21.1-1.1
Bone: maximum force1.32.22.9-1.01.7-1.6
Bone: maximum moment1.42.43.3-0.81.8-1.8
Bone: minimum diameter1.73.15.0-0.91.9-2.2
Bone: periosteal estimation1.32.73.7-1.01.8-1.9
Bone: periosteal perimeter1.32.13.2-0.91.5-1.8
Bone: post-yield work2.33.23.9-2.01.7-1.7
Bone: stiffness2.43.74.4-1.82.1-1.9
Bone: tissue strength1.51.54.12.0-0.40.4
Bone: trabecular number0.40.71.21.1-0.90.3
Bone: trabecular spacing0.20.20.30.4-0.50.5
Bone: trabecular thickness0.10.10.2-0.50.3-0.1
Bone: trabecular tissue density0.71.01.5-1.2-0.51.1
Breakpoint value in progressive ratio session2.62.93.71.9-1.21.9
Distance traveled before self-admin1.41.62.41.60.8-1.3
Distance traveled after self-admin3.43.79.93.1-1.10.0
Delta time in closed arm before/after self-admin0.20.20.30.3-0.50.3
Delta time in open arm before/after self-admin0.70.71.10.11.0-0.9
Diff in mean of infusions in LGA sessions1.82.05.32.3-0.50.6
Extinction: sum of active levers before priming1.81.94.52.1-0.80.6
Active lever presses in extinction session 60.70.72.0-1.40.10.1
Delta distance traveled before/after self-admin2.12.33.01.7-1.61.1
Delta ambulatory time before/after self-admin2.12.33.31.8-1.51.1
Time in closed arm before self-admin1.31.41.8-1.31.4-0.9
Time in closed arm after self-admin0.30.40.9-0.90.4-0.2
Time in open arm before self-admin1.71.82.81.3-1.71.0
Time in open arm after self-admin0.60.71.21.1-0.80.5
Sum of active levers in priming session hrs 5-61.11.12.91.7-0.10.6
Time to tail flick, vehicle, before self-admin0.40.40.6-0.20.7-0.8
Time to tail flick, vehicle, after self-admin3.03.34.7-2.21.9-1.2
Time to tail flick, test, before self-admin2.92.98.52.9-0.2-0.1
Time to tail flick, test, after self-admin0.00.00.1-0.30.0-0.1
Delta time to tail flick, vehicle, before/after SA0.80.81.9-1.40.80.0
Delta time to tail flick, test, before/after SA2.01.85.2-2.30.4-0.2
Ambulatory time before self-admin0.91.01.41.00.7-1.2
Ambulatory time after self-admin2.52.77.72.8-0.4-0.5
Total heroin consumption1.82.22.61.6-1.31.5
Area under the delay curve2.12.23.31.8-1.21.4
Delay disc. indifference point, 0s delay2.12.35.62.4-1.00.3
Delay disc. indifference point, 16s delay0.60.61.0-0.8-0.31.0
Delay disc. indifference point, 2s delay0.70.81.61.3-0.60.7
Delay disc. indifference point, 24s delay0.30.30.8-0.4-0.30.9
Delay disc. indifference point, 4s delay0.00.00.00.10.1-0.0
Delay disc. indifference point, 8s delay1.51.63.21.8-0.80.9
Delay discount exponential model param1.82.03.0-1.71.0-1.3
Delay discount hyperbolic model param1.41.52.6-1.60.9-1.1
Fecal boli incidents, locomotor time 10.10.10.30.50.4-0.2
Change in fecal boli incidents, locomotor task4.34.14.42.0-2.12.0
Time >=10cm from walls, locomotor time 10.10.10.2-0.1-0.20.4
Bouts of movement, locomotor time 11.31.54.42.1-0.10.0
Total resting periods, locomotor time 10.91.02.71.6-0.40.4
Rest time, locomotor task time 11.21.32.0-1.11.4-0.8
Distance moved, locomotor task time 10.50.60.90.7-0.90.6
Vertical activity count, locomotor time 14.54.78.42.9-1.91.4
Time >=10cm from walls, locomotor time 20.50.60.9-0.2-1.00.9
Bouts of movement, locomotor time 20.00.00.10.2-0.30.1
Total resting periods, locomotor time 20.10.10.30.5-0.40.1
Rest time, locomotor task time 20.80.92.01.4-0.70.3
Distance moved, locomotor task time 20.00.00.1-0.0-0.20.0
Vertical activity count, locomotor time 20.91.02.11.5-0.80.5
Weight adjusted by age0.40.50.80.10.9-0.8
Seeking ratio, delayed vs. immediate footshock2.42.86.82.6-1.20.4
Locomotion in novel chamber2.12.62.81.5-1.71.7
Locomotion in novel chamber post-restriction1.51.82.11.5-1.31.2
Progressive ratio1.82.13.81.9-1.50.7
Food seeking constrained by brief footshock11.413.836.16.0-2.10.9
Seeking ratio, punishment vs. effort0.70.92.61.60.2-0.2
Run reversals in cocaine runway, females0.40.30.6-0.70.70.1
Run reversals in cocaine runway, males0.40.30.7-0.80.3-0.5
Latency to leave start box in cocaine runway0.60.61.5-0.41.2-0.4
Latency to leave start box in cocaine runway, F0.20.20.50.30.70.1
Latency to leave start box in cocaine runway, M1.41.41.6-1.31.2-1.0
Cd content in liver0.40.40.80.90.5-0.5
Co content in liver0.70.91.4-0.71.2-0.8
Cu content in liver1.41.72.6-1.61.1-1.0
Fe content in liver0.20.30.4-0.60.5-0.4
K content in liver0.00.00.0-0.10.0-0.2
Mg content in liver0.10.10.2-0.0-0.40.5
Mn content in liver0.30.30.50.3-0.60.7
Na content in liver1.51.62.40.6-1.61.4
Rb content in liver0.20.20.4-0.70.2-0.4
Se content in liver2.12.53.21.1-1.81.8
Sr content in liver12.111.115.53.9-3.12.8
Zn content in liver0.40.41.2-1.10.10.2