| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | gene expression | ENSRNOG00000050790 | 0.1419 | 0.0879 | 5.9e-05 | 0.066 | 0.059 | 0.062 | 0.063 | 2.0e-04 | 4.2e-04 | 3.0e-04 | 2.8e-04 |
| 2 | Brain | gene expression | ENSRNOG00000050790 | 0.2800 | 0.1500 | 1.0e-13 | 0.154 | 0.133 | 0.147 | 0.145 | 3.6e-14 | 2.6e-12 | 1.5e-13 | 2.3e-13 |
| 3 | Liver | gene expression | ENSRNOG00000050790 | 0.0410 | 0.0340 | 2.6e-03 | 0.016 | 0.020 | 0.021 | 0.021 | 6.1e-03 | 2.3e-03 | 2.0e-03 | 2.1e-03 |
| 4 | Liver | mRNA stability | ENSRNOG00000050790 | 0.0560 | 0.0367 | 1.6e-06 | 0.024 | 0.046 | 0.047 | 0.042 | 9.4e-04 | 6.4e-06 | 6.3e-06 | 1.6e-05 |
| 5 | PL | gene expression | ENSRNOG00000050790 | 0.0523 | 0.0428 | 6.1e-03 | 0.028 | 0.022 | 0.009 | 0.026 | 3.4e-03 | 8.3e-03 | 6.1e-02 | 4.4e-03 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|---|---|---|
| Condit. Reinf. lever presses | 9.3 | 12.5 | 18.3 | 3.2 | 4.0 | 3.9 | 1.4 | 4.3 |
| Food seeking constrained by brief footshock | 8.2 | 10.0 | 16.3 | 2.5 | 4.0 | 3.6 | 0.9 | 3.7 |
| Pavlov. Cond. lever latency | 7.9 | 10.1 | 14.3 | -3.1 | -3.4 | -3.5 | -1.7 | -3.8 |
| Tibialis anterior weight | 6.8 | 23.5 | 31.1 | 4.7 | 5.3 | 5.4 | 2.7 | 5.6 |
| Distance traveled before self-admin | 6.5 | 7.0 | 11.2 | 2.2 | 3.1 | 2.9 | 0.9 | 3.3 |
| Number of licking bursts | 6.1 | 7.2 | 8.2 | 2.8 | 2.8 | 2.9 | 2.3 | 2.7 |
| Pavlov. Cond. lever contacts | 5.5 | 6.5 | 9.4 | 2.5 | 2.7 | 2.8 | 1.3 | 3.1 |
| Indifference point AUC | 5.4 | 6.4 | 8.8 | 2.4 | 3.0 | 2.8 | 1.3 | 2.7 |
| Time in novel zone, NPP test | 5.3 | 5.6 | 6.9 | -2.6 | -2.1 | -2.4 | -2.5 | -2.1 |
| Bone: elastic displacement | 5.3 | 6.0 | 8.2 | -2.3 | -2.9 | -2.7 | -1.1 | -2.9 |
| Extensor digitorum longus weight | 4.9 | 19.7 | 25.1 | 4.6 | 4.5 | 4.8 | 3.1 | 5.0 |
| Novelty place preference | 4.5 | 4.7 | 5.8 | -2.4 | -2.0 | -2.2 | -2.3 | -1.9 |
| Ambulatory time before self-admin | 4.4 | 4.6 | 8.3 | 1.6 | 2.6 | 2.4 | 0.3 | 2.9 |
| Sum of active levers in priming session hrs 5-6 | 4.3 | 4.2 | 5.0 | -2.2 | -1.9 | -2.1 | -2.2 | -1.9 |
| Incentive salience index mean | 4.2 | 5.0 | 7.1 | 2.1 | 2.5 | 2.5 | 1.1 | 2.7 |
| Bone: stiffness | 4.1 | 6.5 | 7.5 | 2.7 | 2.5 | 2.7 | 2.1 | 2.6 |
| BMI without tail | 4.0 | 8.4 | 11.2 | 2.8 | 3.4 | 3.2 | 1.6 | 3.1 |
| Rb content in liver | 4.0 | 5.0 | 5.7 | -2.4 | -2.3 | -2.3 | -1.9 | -2.2 |
| Condit. Reinf. inactive responses | 3.8 | 4.7 | 5.3 | 2.2 | 2.1 | 2.3 | 1.9 | 2.3 |
| Novel to familiar place preference ratio | 3.5 | 3.6 | 5.0 | -2.2 | -1.6 | -1.8 | -2.2 | -1.6 |
| Bone: trabecular tissue density | 3.5 | 4.9 | 5.7 | 2.4 | 2.3 | 2.4 | 1.6 | 2.3 |
| Seeking ratio, punishment vs. effort | 3.4 | 4.1 | 5.5 | 2.0 | 2.1 | 2.2 | 1.3 | 2.3 |
| Stereotopy head waving bouts, day 7 | 3.2 | 3.6 | 4.3 | 2.1 | 2.0 | 2.1 | 1.2 | 2.1 |
| Pavlov. Cond. index score | 3.2 | 4.1 | 5.6 | 2.0 | 2.1 | 2.2 | 1.2 | 2.4 |
| Time in closed arm before self-admin | 3.2 | 3.6 | 4.6 | -2.0 | -1.8 | -2.1 | -1.4 | -2.1 |
| Seeking ratio, delayed vs. immediate footshock | 3.1 | 3.6 | 4.3 | 1.8 | 2.1 | 2.1 | 1.4 | 2.0 |
| Short access day 1 total inactive lever presses | 3.0 | 3.3 | 5.7 | 1.4 | 2.4 | 2.1 | 0.3 | 2.1 |
| Short access day 1 total infusions | 3.0 | 3.2 | 5.5 | 1.2 | 2.3 | 2.0 | -0.1 | 2.2 |
| Condit. Reinf. inactive responses | 3.0 | 3.5 | 4.1 | 1.9 | 1.9 | 2.0 | 1.6 | 1.9 |
| Pavlov. Cond. latency score | 3.0 | 3.8 | 5.4 | 1.9 | 2.0 | 2.1 | 1.1 | 2.3 |
| Bone: maximum force | 3.0 | 5.3 | 6.1 | 2.5 | 2.2 | 2.4 | 2.0 | 2.4 |
| Pavlov. Cond. lever latency | 2.9 | 3.9 | 5.4 | -2.3 | -1.5 | -2.0 | -2.3 | -1.8 |
| Condit. Reinf. active responses | 2.8 | 3.4 | 4.2 | 1.8 | 1.9 | 2.0 | 1.3 | 2.1 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.8 | 3.6 | 4.5 | 2.0 | 1.9 | 2.0 | 1.3 | 2.1 |
| Pavlov. Cond. response bias | 2.8 | 3.4 | 4.8 | 1.7 | 2.0 | 2.1 | 0.9 | 2.2 |
| Distance traveled after self-admin | 2.8 | 3.1 | 3.8 | 2.0 | 1.5 | 1.8 | 1.7 | 1.8 |
| Mean num. licks in bursts | 2.7 | 3.2 | 4.1 | -1.8 | -2.0 | -1.9 | -1.2 | -2.0 |
| Pavlov. Cond. change in total contacts | 2.7 | 2.9 | 4.6 | 1.5 | 1.9 | 1.9 | 0.5 | 2.1 |
| Time in novel zone, hab. session 1 | 2.6 | 2.5 | 6.7 | -2.0 | -0.7 | -1.0 | -2.6 | -0.7 |
| Se content in liver | 2.6 | 3.1 | 4.4 | 2.1 | 1.6 | 1.7 | 1.9 | 1.5 |
| Body weight | 2.5 | 10.4 | 12.5 | 3.3 | 3.4 | 3.5 | 2.3 | 3.4 |
| Social response proportion | 2.5 | 2.8 | 3.9 | -1.6 | -1.7 | -1.9 | -1.0 | -2.0 |
| Time in open arm before self-admin | 2.5 | 2.7 | 4.8 | 1.3 | 1.9 | 1.8 | 0.2 | 2.2 |
| Time to tail flick, vehicle, before self-admin | 2.5 | 2.5 | 3.5 | -1.4 | -1.9 | -1.8 | -0.9 | -1.7 |
| Reaction time premature initiation rate | 2.4 | 3.2 | 4.9 | -1.5 | -2.2 | -2.0 | -0.4 | -2.2 |
| Bone: maximum moment | 2.4 | 4.1 | 5.1 | 2.3 | 1.8 | 2.1 | 2.0 | 2.0 |
| Condit. Reinf. lever presses | 2.3 | 3.2 | 4.3 | 2.0 | 1.3 | 1.7 | 2.1 | 1.6 |
| Condit. Reinf. lever reinforcers received | 2.3 | 3.2 | 4.0 | 1.7 | 1.9 | 2.0 | 1.3 | 2.0 |
| Latency to leave start box in cocaine runway, M | 2.3 | 2.2 | 3.3 | 1.4 | 1.5 | 1.6 | 0.8 | 1.8 |
| Distance moved, locomotor task time 1 | 2.2 | 2.4 | 4.3 | 0.8 | 2.1 | 1.7 | -0.5 | 2.0 |
| Tail length | 2.1 | 6.2 | 9.1 | 2.2 | 3.0 | 2.9 | 0.9 | 2.9 |
| Intraocular pressure | 2.1 | 3.0 | 5.3 | 1.5 | 2.3 | 2.0 | 0.6 | 1.8 |
| Median of all reaction times | 2.1 | 2.9 | 4.3 | -1.5 | -2.0 | -1.9 | -0.3 | -2.1 |
| Intermittent access intake escalation 2 | 2.1 | 2.1 | 3.8 | 1.7 | 1.1 | 1.3 | 2.0 | 1.0 |
| Bone: cortical area | 2.1 | 3.1 | 3.8 | 2.0 | 1.6 | 1.8 | 1.8 | 1.7 |
| Bone: maximum diameter | 2.0 | 3.7 | 4.6 | 2.0 | 2.0 | 2.1 | 1.4 | 2.0 |
| Locomotion in novel chamber post-restriction | 2.0 | 2.4 | 4.5 | 1.9 | 0.9 | 1.3 | 2.1 | 1.2 |
| Indifference point function ln k | 1.9 | 2.7 | 3.6 | -1.7 | -1.9 | -1.8 | -1.1 | -1.7 |
| Indifference point function log k | 1.9 | 2.7 | 3.6 | -1.7 | -1.9 | -1.8 | -1.1 | -1.7 |
| Reaction time premature initiations | 1.9 | 2.7 | 3.7 | -1.5 | -1.9 | -1.8 | -0.7 | -1.9 |
| Condit. Reinf. active responses | 1.9 | 2.7 | 3.4 | 1.6 | 1.7 | 1.8 | 1.1 | 1.8 |
| Intermittent access day 1 locomotion | 1.9 | 2.0 | 2.6 | -1.6 | -1.0 | -1.3 | -1.5 | -1.4 |
| Bone: elastic work | 1.9 | 2.5 | 4.6 | -0.7 | -2.1 | -1.7 | 0.7 | -2.0 |
| Active lever presses in extinction session 6 | 1.9 | 1.9 | 2.2 | -1.4 | -1.2 | -1.4 | -1.3 | -1.5 |
| Cocaine response after cond. corrected | 1.8 | 2.0 | 4.3 | -1.6 | -1.0 | -1.2 | -2.1 | -0.9 |
| Rest time, locomotor task time 1 | 1.8 | 1.9 | 3.4 | -0.1 | -1.8 | -1.3 | 1.2 | -1.8 |
| Delay discounting total patch changes 6 sec | 1.7 | 2.6 | 4.4 | 1.2 | 2.1 | 1.8 | -0.4 | 2.0 |
| Locomotion velocity, session 2 | 1.7 | 2.0 | 2.3 | 1.5 | 1.5 | 1.5 | 1.2 | 1.4 |
| Degree of sensitization stereotypy | 1.7 | 1.9 | 2.2 | 1.5 | 1.4 | 1.5 | 1.0 | 1.5 |
| Fecal boli incidents, locomotor time 1 | 1.7 | 1.8 | 2.5 | -1.3 | -1.6 | -1.5 | -0.8 | -1.4 |
| BMI with tail | 1.6 | 5.2 | 6.8 | 2.6 | 2.0 | 2.3 | 2.4 | 2.0 |
| Delay discounting total patch changes 24 sec | 1.6 | 2.0 | 3.4 | 1.2 | 1.6 | 1.6 | 0.2 | 1.8 |
| Delay discounting time to switch 0 sec | 1.6 | 2.5 | 3.9 | -1.4 | -1.9 | -1.8 | -0.1 | -2.0 |
| Reaction time mean minus median AUC | 1.6 | 2.1 | 6.1 | 1.6 | 0.5 | 0.9 | 2.5 | 0.6 |
| Cocaine response after cond. not corrected | 1.6 | 1.8 | 4.6 | -1.5 | -0.8 | -1.0 | -2.1 | -0.6 |
| Locomotion velocity, session 1 | 1.6 | 1.7 | 5.6 | -0.7 | 1.1 | 0.5 | -2.4 | 1.0 |
| Locomotion distance, session 2 | 1.5 | 2.1 | 3.6 | 1.1 | 1.9 | 1.7 | -0.1 | 1.8 |
| Delay disc. indifference point, 16s delay | 1.5 | 1.5 | 2.8 | -1.6 | -0.6 | -1.0 | -1.7 | -0.9 |
| Total resting periods, locomotor time 1 | 1.5 | 1.7 | 3.3 | -0.9 | -1.8 | -1.4 | 0.2 | -1.5 |
| Delay discounting total patch changes 12 sec | 1.4 | 1.8 | 2.5 | 1.4 | 1.6 | 1.5 | 0.8 | 1.4 |
| Reaction time mean AUC | 1.4 | 1.8 | 3.1 | -0.7 | -1.7 | -1.4 | 0.8 | -1.7 |
| Pavlov. Cond. lever contacts | 1.4 | 1.9 | 2.7 | 1.6 | 1.0 | 1.4 | 1.5 | 1.3 |
| Intermittent access terminal intake (last 3 days) | 1.4 | 1.6 | 2.1 | 1.2 | 1.5 | 1.4 | 0.8 | 1.3 |
| Progressive ratio test 1 inactive lever presses | 1.4 | 1.5 | 2.9 | 0.5 | 1.7 | 1.3 | -0.5 | 1.5 |
| Locomotion distance, session 3 | 1.4 | 1.5 | 2.5 | 0.9 | 1.6 | 1.5 | 0.1 | 1.5 |
| Time in novel zone, hab. session 2 | 1.4 | 1.4 | 3.6 | -1.6 | -0.5 | -0.8 | -1.9 | -0.4 |
| Bone: periosteal estimation | 1.4 | 2.8 | 3.8 | 1.6 | 1.8 | 1.9 | 0.9 | 1.9 |
| Delta time in closed arm before/after self-admin | 1.4 | 1.3 | 2.0 | 1.3 | 1.0 | 1.1 | 1.4 | 0.8 |
| Time in open arm after self-admin | 1.4 | 1.5 | 2.6 | 0.9 | 1.5 | 1.4 | 0.2 | 1.6 |
| Vertical activity count, locomotor time 1 | 1.4 | 1.5 | 2.8 | 0.4 | 1.7 | 1.3 | -0.8 | 1.5 |
| Light reinforcement 1 | 1.3 | 2.4 | 4.4 | 0.5 | 2.1 | 1.7 | -0.7 | 2.0 |
| Bone: post-yield work | 1.3 | 1.8 | 2.6 | 1.3 | 1.5 | 1.5 | 0.4 | 1.6 |
| Water consumed over 24 hours | 1.2 | 1.5 | 1.7 | 1.3 | 1.3 | 1.3 | 0.9 | 1.2 |
| Reaction time mean | 1.2 | 1.6 | 2.7 | -0.7 | -1.6 | -1.3 | 0.7 | -1.6 |
| Reaction time omissions | 1.2 | 1.6 | 2.5 | -1.2 | -1.6 | -1.4 | -0.4 | -1.5 |
| Saline control response | 1.2 | 1.6 | 2.8 | 1.0 | 1.5 | 1.5 | 0.0 | 1.7 |
| Lifetime Intake | 1.2 | 1.3 | 2.7 | 0.7 | 1.6 | 1.3 | -0.1 | 1.3 |
| Stereotopy head waving duration, day 7 | 1.2 | 1.5 | 2.0 | 1.4 | 1.2 | 1.3 | 0.7 | 1.4 |
| Locomotion velocity, NPP test | 1.2 | 1.8 | 3.0 | 1.2 | 1.7 | 1.5 | 0.4 | 1.5 |
| Bone: final force | 1.2 | 2.0 | 2.3 | 1.5 | 1.4 | 1.5 | 1.2 | 1.5 |
| Extinction: sum of active levers before priming | 1.2 | 1.2 | 1.8 | -1.0 | -1.3 | -1.2 | -0.5 | -1.3 |
| Delay disc. indifference point, 0s delay | 1.2 | 1.3 | 1.6 | -1.1 | -1.1 | -1.2 | -1.3 | -1.0 |
| Cd content in liver | 1.2 | 1.3 | 2.1 | 1.1 | 1.1 | 1.1 | 1.5 | 0.8 |
| Mg content in liver | 1.2 | 1.2 | 1.4 | -1.1 | -1.1 | -1.2 | -0.9 | -1.1 |
| Delay discounting water rate 6 sec | 1.1 | 1.7 | 2.3 | 1.3 | 1.3 | 1.4 | 0.8 | 1.5 |
| Locomotor testing rearing | 1.1 | 1.8 | 2.6 | 1.2 | 1.5 | 1.5 | 0.5 | 1.6 |
| Reaction time mean minus median | 1.1 | 1.5 | 5.8 | 1.2 | -0.1 | 0.3 | 2.4 | -0.1 |
| Conditioned reinforcement - actives | 1.1 | 1.1 | 1.3 | 1.1 | 1.1 | 1.1 | 0.9 | 0.8 |
| Intermittent access day 15 total locomotion | 1.1 | 1.2 | 1.6 | -1.2 | -0.9 | -1.1 | -0.9 | -1.3 |
| Short access total infusions | 1.1 | 1.2 | 2.5 | 0.3 | 1.6 | 1.2 | -0.7 | 1.3 |
| Locomotion velocity, hab. session 1 | 1.1 | 1.6 | 2.8 | 1.5 | 1.0 | 1.1 | 1.7 | 0.8 |
| Progressive ratio test 1 breakpoint | 1.0 | 1.0 | 1.9 | 0.7 | 1.4 | 1.2 | 0.1 | 1.2 |
| Short access day 10 total locomotion | 1.0 | 1.1 | 2.1 | -0.8 | -1.1 | -1.1 | -0.2 | -1.5 |
| Number of responses in last shaping day | 1.0 | 1.0 | 2.5 | -0.4 | 1.0 | 0.6 | -1.6 | 1.0 |
| Time in familiar zone, hab. session 1 | 1.0 | 1.0 | 2.6 | 0.4 | -1.0 | -0.6 | 1.6 | -0.9 |
| Bone: apparent density | 1.0 | 1.6 | 2.0 | 1.4 | 1.0 | 1.3 | 1.4 | 1.2 |
| Bone: final moment | 1.0 | 1.6 | 2.0 | 1.4 | 1.1 | 1.3 | 1.3 | 1.2 |
| Bone: marrow area | 1.0 | 2.0 | 3.1 | 1.2 | 1.7 | 1.7 | 0.2 | 1.8 |
| Bone: trabecular number | 1.0 | 1.5 | 2.5 | 1.4 | 0.9 | 1.2 | 1.6 | 1.0 |
| Breakpoint value in progressive ratio session | 1.0 | 1.1 | 2.8 | -1.2 | -0.7 | -0.8 | -1.7 | -0.5 |
| Delay discounting water rate 0 sec | 0.9 | 1.5 | 2.4 | 0.8 | 1.5 | 1.3 | -0.5 | 1.6 |
| Light reinforcement 2 | 0.9 | 1.2 | 1.9 | -0.2 | 1.4 | 0.8 | -1.3 | 1.2 |
| Cocaine response before conditioning | 0.9 | 1.1 | 1.4 | 1.1 | 1.0 | 1.1 | 0.9 | 1.2 |
| Pavlov. Cond. change in total contacts | 0.9 | 1.3 | 3.6 | 1.4 | 0.2 | 0.7 | 1.9 | 0.4 |
| Intermittent access intake day 1-15 change | 0.9 | 0.9 | 2.1 | 1.2 | 0.6 | 0.8 | 1.5 | 0.5 |
| Intermittent access intake escalation | 0.9 | 0.9 | 1.3 | 1.1 | 0.8 | 0.9 | 1.1 | 0.7 |
| Total locomotion distance, NPP test | 0.9 | 1.3 | 2.4 | 0.9 | 1.6 | 1.3 | 0.1 | 1.3 |
| Bone: cortical thickness | 0.9 | 1.5 | 3.3 | 1.4 | 0.7 | 1.0 | 1.8 | 0.8 |
| Bone: endosteal estimation | 0.9 | 2.0 | 3.1 | 1.1 | 1.7 | 1.6 | -0.0 | 1.7 |
| Ambulatory time after self-admin | 0.9 | 1.0 | 1.9 | 0.9 | 0.9 | 1.0 | 0.5 | 1.4 |
| Change in fecal boli incidents, locomotor task | 0.9 | 0.9 | 1.5 | 0.5 | 1.2 | 1.1 | -0.0 | 1.2 |
| Bouts of movement, locomotor time 1 | 0.9 | 1.0 | 2.0 | -0.8 | -1.4 | -1.1 | -0.0 | -1.1 |
| Bouts of movement, locomotor time 2 | 0.9 | 1.0 | 1.2 | 1.0 | 0.8 | 0.9 | 1.1 | 1.1 |
| Latency to leave start box in cocaine runway | 0.9 | 1.0 | 1.2 | 1.0 | 0.9 | 1.0 | 0.9 | 1.1 |
| Co content in liver | 0.9 | 1.1 | 1.6 | -1.2 | -0.8 | -1.0 | -1.3 | -0.8 |
| Food consumed during 24 hour testing period | 0.8 | 1.0 | 1.7 | 0.8 | 1.3 | 1.1 | 0.2 | 1.2 |
| Std. dev. reaction times | 0.8 | 1.0 | 3.2 | 0.4 | -0.9 | -0.5 | 1.8 | -0.9 |
| Intermitt. access escalation Index | 0.8 | 0.7 | 1.2 | 0.7 | 1.1 | 1.0 | 0.2 | 1.0 |
| Time in familiar zone, hab. session 2 | 0.8 | 0.9 | 1.5 | -0.1 | -1.2 | -0.9 | 0.7 | -1.2 |
| Bone: endosteal perimeter | 0.8 | 1.7 | 2.8 | 0.9 | 1.6 | 1.5 | -0.1 | 1.7 |
| Area under the delay curve | 0.8 | 0.9 | 1.2 | -1.1 | -0.8 | -0.9 | -1.1 | -0.7 |
| Delay discount exponential model param | 0.8 | 0.8 | 1.1 | 1.0 | 0.7 | 0.8 | 1.0 | 0.7 |
| Length with tail | 0.7 | 2.4 | 3.8 | 1.2 | 1.9 | 1.8 | 0.0 | 1.9 |
| Times rat made contact with spout | 0.7 | 0.9 | 1.3 | 1.0 | 0.7 | 0.9 | 1.1 | 0.7 |
| Delay discounting total patch changes 0 sec | 0.7 | 1.1 | 1.8 | 0.1 | 1.1 | 0.8 | -1.3 | 1.3 |
| Pavlov. Cond. response bias | 0.7 | 0.9 | 1.7 | 1.2 | 0.5 | 0.9 | 1.3 | 0.7 |
| Conditioned reinforcement - inactives | 0.7 | 0.8 | 1.0 | 1.0 | 1.0 | 1.0 | 0.6 | 0.8 |
| Intermittent access total infusions | 0.7 | 0.8 | 1.5 | 0.7 | 1.2 | 1.0 | 0.4 | 0.9 |
| Progressive ratio test 1 active lever presses | 0.7 | 0.8 | 1.5 | 0.6 | 1.2 | 1.0 | 0.1 | 1.0 |
| Progressive ratio test 2 inactive lever presses | 0.7 | 0.8 | 1.4 | 0.7 | 1.2 | 1.0 | 0.2 | 1.0 |
| Degree of sensitization distance | 0.7 | 0.7 | 1.0 | -0.8 | -1.0 | -0.9 | -0.3 | -0.9 |
| Delta time to tail flick, vehicle, before/after SA | 0.7 | 0.7 | 1.2 | 0.6 | 1.1 | 0.9 | 0.3 | 0.9 |
| Na content in liver | 0.7 | 0.8 | 1.1 | -0.7 | -1.0 | -1.1 | -0.4 | -1.0 |
| Glucose | 0.6 | 0.9 | 1.3 | 0.8 | 1.1 | 1.0 | 0.2 | 1.1 |
| Liver weight, left | 0.6 | 1.0 | 1.5 | 1.0 | 1.2 | 1.1 | 0.6 | 1.0 |
| Indifference point 0 sec | 0.6 | 1.0 | 3.4 | -0.4 | 0.7 | 0.4 | -1.8 | 1.0 |
| Reaction time num false alarms AUC | 0.6 | 0.9 | 1.4 | 1.2 | 0.6 | 0.9 | 1.1 | 0.8 |
| Intermittent access day 1 total infusions | 0.6 | 0.6 | 1.3 | -1.0 | -0.4 | -0.7 | -1.1 | -0.6 |
| Intermittent access standard deviation | 0.6 | 0.6 | 0.8 | 0.8 | 0.9 | 0.8 | 0.8 | 0.6 |
| Post-drug Anxiety | 0.6 | 0.7 | 1.1 | 0.7 | 1.0 | 0.9 | 0.3 | 0.9 |
| Baseline Anxiety | 0.6 | 0.7 | 1.2 | 1.0 | 0.6 | 0.7 | 1.1 | 0.5 |
| Short access day 10 total infusions | 0.6 | 0.7 | 1.3 | -0.0 | 1.1 | 0.7 | -0.9 | 0.8 |
| Short access day 1 locomotion | 0.6 | 0.6 | 1.4 | -1.0 | -0.2 | -0.5 | -1.2 | -0.5 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.6 | 0.9 | 0.7 | 0.8 | 0.9 | 0.5 | 0.9 |
| Locomotion velocity, hab. session 2 | 0.6 | 0.8 | 1.2 | 0.9 | 1.1 | 0.9 | 0.6 | 0.8 |
| Delta ambulatory time before/after self-admin | 0.6 | 0.7 | 1.1 | -0.6 | -1.1 | -0.9 | 0.0 | -1.1 |
| Time to tail flick, test, before self-admin | 0.6 | 0.6 | 0.7 | 0.7 | 0.8 | 0.8 | 0.7 | 0.7 |
| Delta time to tail flick, test, before/after SA | 0.6 | 0.5 | 0.8 | -0.7 | -0.7 | -0.8 | -0.4 | -0.9 |
| Delay discount hyperbolic model param | 0.6 | 0.7 | 1.0 | 1.0 | 0.7 | 0.8 | 1.0 | 0.7 |
| Cu content in liver | 0.6 | 0.7 | 1.4 | -0.5 | -1.0 | -0.9 | 0.1 | -1.2 |
| Mn content in liver | 0.6 | 0.7 | 1.7 | 1.2 | 0.1 | 0.5 | 1.3 | 0.6 |
| Left kidney weight | 0.5 | 1.4 | 2.3 | 0.9 | 1.5 | 1.4 | -0.0 | 1.5 |
| Pavlov. Cond. latency score | 0.5 | 0.7 | 1.9 | 1.0 | 0.2 | 0.7 | 1.4 | 0.4 |
| Conditioned locomotion | 0.5 | 0.6 | 0.8 | 0.7 | 0.9 | 0.8 | 0.5 | 0.7 |
| Intermitt. access day 1 inactive lever presses | 0.5 | 0.5 | 0.9 | 0.5 | 1.0 | 0.8 | 0.1 | 0.8 |
| Intermittent access total locomotion | 0.5 | 0.6 | 1.3 | -0.6 | -0.8 | -0.8 | -0.2 | -1.1 |
| Incentive Sensitization - Responses | 0.5 | 0.5 | 1.2 | 0.4 | 1.1 | 0.8 | -0.1 | 0.7 |
| Progressive ratio test 2 active lever presses | 0.5 | 0.5 | 1.2 | 0.1 | 1.1 | 0.7 | -0.6 | 0.7 |
| Total sessions with >9 infusions | 0.5 | 0.6 | 1.0 | -0.1 | 1.0 | 0.6 | -0.9 | 0.8 |
| One hour access (0.3 mA shock) | 0.5 | 0.6 | 1.1 | 0.4 | 1.1 | 0.8 | -0.4 | 0.9 |
| Locomotion distance, session 1 | 0.5 | 0.6 | 1.9 | -0.5 | 0.7 | 0.3 | -1.4 | 0.5 |
| Condit. Reinf. active-inactive response ratio | 0.5 | 0.5 | 0.7 | -0.6 | -0.9 | -0.8 | -0.4 | -0.8 |
| Total locomotion distance, hab. session 2 | 0.5 | 0.6 | 0.9 | 0.8 | 1.0 | 0.9 | 0.5 | 0.7 |
| Pavlov. Cond. magazine entry number | 0.5 | 0.7 | 0.9 | -0.8 | -0.9 | -1.0 | -0.5 | -1.0 |
| Bone surface | 0.5 | 0.8 | 1.3 | 0.8 | 1.0 | 1.1 | 0.3 | 1.1 |
| Bone volume | 0.5 | 0.9 | 1.1 | 0.9 | 0.9 | 1.1 | 0.7 | 1.0 |
| Total resting periods, locomotor time 2 | 0.5 | 0.5 | 1.0 | 0.7 | 0.4 | 0.6 | 1.0 | 0.8 |
| Rest time, locomotor task time 2 | 0.5 | 0.6 | 1.5 | -0.2 | -1.2 | -0.8 | 0.3 | -0.9 |
| Fe content in liver | 0.5 | 0.6 | 1.7 | -0.3 | 0.6 | 0.4 | -1.3 | 0.8 |
| K content in liver | 0.5 | 0.5 | 0.9 | -0.8 | -0.5 | -0.7 | -1.0 | -0.5 |
| Sr content in liver | 0.5 | 0.5 | 0.7 | 0.8 | 0.5 | 0.7 | 0.8 | 0.6 |
| Epididymis fat weight | 0.4 | 1.0 | 1.8 | 0.8 | 1.1 | 1.1 | 0.3 | 1.4 |
| Heart weight | 0.4 | 0.6 | 0.8 | 0.7 | 0.9 | 0.8 | 0.4 | 0.9 |
| Length without tail | 0.4 | 0.8 | 1.0 | -0.9 | -1.0 | -0.9 | -0.8 | -0.7 |
| Soleus weight | 0.4 | 1.3 | 4.8 | -1.2 | 0.2 | -0.2 | -2.2 | 0.1 |
| Mean time between licks in bursts | 0.4 | 0.6 | 0.7 | -0.9 | -0.8 | -0.7 | -0.5 | -0.8 |
| Delay discounting total patch changes 18 sec | 0.4 | 0.5 | 0.9 | 0.5 | 0.9 | 0.7 | -0.4 | 1.0 |
| Delay discounting water rate 18 sec | 0.4 | 0.6 | 1.4 | 0.9 | 0.4 | 0.5 | 1.2 | 0.4 |
| Social responses | 0.4 | 0.5 | 0.7 | 0.7 | 0.8 | 0.8 | 0.3 | 0.7 |
| Condit. Reinf. active minus inactive responses | 0.4 | 0.6 | 0.6 | 0.8 | 0.7 | 0.8 | 0.7 | 0.8 |
| Intermittent access day 15 total infusions | 0.4 | 0.4 | 0.7 | 0.6 | 0.8 | 0.7 | 0.4 | 0.6 |
| Short access day 10 total inactive lever presses | 0.4 | 0.4 | 0.5 | 0.7 | 0.7 | 0.7 | 0.4 | 0.7 |
| One hour access (shock baseline) | 0.4 | 0.5 | 1.1 | 0.1 | 1.0 | 0.7 | -0.4 | 0.8 |
| Total locomotion distance, hab. session 1 | 0.4 | 0.5 | 1.8 | 0.9 | 0.1 | 0.3 | 1.3 | -0.0 |
| Total zone transitions, hab. session 2 | 0.4 | 0.5 | 0.9 | 0.1 | 1.0 | 0.6 | -0.7 | 0.7 |
| Bone: connectivity density | 0.4 | 0.6 | 1.1 | 0.8 | 0.5 | 0.7 | 1.1 | 0.6 |
| Bone: periosteal perimeter | 0.4 | 0.7 | 1.2 | 0.5 | 1.1 | 1.0 | -0.2 | 1.1 |
| Time in closed arm after self-admin | 0.4 | 0.4 | 0.7 | -0.6 | -0.6 | -0.7 | -0.2 | -0.8 |
| Delay disc. indifference point, 24s delay | 0.4 | 0.4 | 0.7 | -0.7 | -0.5 | -0.6 | -0.5 | -0.8 |
| Weight adjusted by age | 0.4 | 0.4 | 1.4 | -0.5 | 0.2 | 0.1 | -1.2 | 0.6 |
| Std. dev. time between licks in bursts | 0.3 | 0.4 | 0.6 | -0.6 | -0.7 | -0.7 | -0.1 | -0.6 |
| Reaction time num false alarms | 0.3 | 0.4 | 1.3 | 0.8 | -0.1 | 0.3 | 1.1 | 0.2 |
| Pavlov. Cond. index score | 0.3 | 0.4 | 1.3 | 0.8 | 0.0 | 0.5 | 1.1 | 0.3 |
| Pavlov. Cond. magazine entry number | 0.3 | 0.3 | 1.3 | -0.6 | 0.2 | -0.2 | -1.1 | -0.0 |
| Pavlov. Cond. intertrial magazine entries | 0.3 | 0.4 | 0.6 | 0.5 | 0.8 | 0.6 | 0.2 | 0.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 1.4 | 0.8 | -0.0 | 0.4 | 1.2 | 0.2 |
| Cocaine induced anxiety | 0.3 | 0.4 | 0.5 | -0.7 | -0.6 | -0.6 | -0.6 | -0.5 |
| Incentive Sensitization - Breakpoint | 0.3 | 0.3 | 0.8 | 0.2 | 0.9 | 0.6 | -0.2 | 0.5 |
| Locomotion velocity, session 3 | 0.3 | 0.3 | 1.1 | -0.4 | 0.4 | 0.3 | -1.0 | 0.5 |
| Locomotion velocity, session 8 | 0.3 | 0.4 | 1.1 | -0.3 | 0.6 | 0.3 | -1.1 | 0.6 |
| Total zone transitions, NPP test | 0.3 | 0.5 | 0.9 | 0.2 | 1.0 | 0.7 | -0.6 | 0.8 |
| Pavlov. Cond. intertrial magazine entries | 0.3 | 0.3 | 0.4 | 0.6 | 0.6 | 0.6 | 0.5 | 0.5 |
| Bone: cortical porosity | 0.3 | 0.3 | 0.5 | -0.4 | -0.7 | -0.7 | -0.2 | -0.7 |
| Total heroin consumption | 0.3 | 0.3 | 0.9 | -0.6 | -0.3 | -0.4 | -0.9 | -0.2 |
| Distance moved, locomotor task time 2 | 0.3 | 0.3 | 0.5 | 0.6 | 0.7 | 0.6 | 0.4 | 0.4 |
| Progressive ratio | 0.3 | 0.3 | 0.7 | -0.7 | -0.1 | -0.4 | -0.8 | -0.5 |
| Delay discounting water rate 24 sec | 0.2 | 0.2 | 0.6 | 0.2 | -0.5 | -0.2 | 0.8 | -0.4 |
| Reaction time false alarm rate | 0.2 | 0.3 | 1.1 | 0.8 | -0.1 | 0.2 | 1.0 | 0.1 |
| Conditioned locomotion | 0.2 | 0.3 | 1.0 | -0.4 | 0.2 | -0.0 | -1.0 | 0.3 |
| Pavlov. Cond. magazine entry latency | 0.2 | 0.2 | 0.5 | -0.3 | -0.7 | -0.4 | 0.0 | -0.5 |
| Intermitt. access day 15 inactive lever presses | 0.2 | 0.2 | 0.3 | 0.3 | 0.6 | 0.5 | -0.2 | 0.5 |
| Progressive ratio test 2 breakpoint | 0.2 | 0.3 | 0.6 | -0.1 | 0.7 | 0.4 | -0.7 | 0.4 |
| Locomotion distance, session 8 | 0.2 | 0.3 | 0.5 | -0.1 | 0.7 | 0.5 | -0.7 | 0.7 |
| Pavlov. Cond. magazine entry latency | 0.2 | 0.3 | 0.5 | 0.5 | 0.5 | 0.6 | 0.2 | 0.7 |
| Bone: cortical apparent density | 0.2 | 0.3 | 1.1 | 0.2 | -0.4 | -0.1 | 1.0 | -0.4 |
| Bone: cortical tissue density | 0.2 | 0.3 | 0.8 | 0.1 | -0.4 | -0.2 | 0.9 | -0.5 |
| Bone: tissue strength | 0.2 | 0.1 | 0.3 | 0.5 | 0.3 | 0.3 | 0.5 | 0.2 |
| Bone: trabecular thickness | 0.2 | 0.2 | 0.4 | -0.4 | -0.7 | -0.5 | -0.2 | -0.5 |
| Delta time in open arm before/after self-admin | 0.2 | 0.2 | 0.5 | -0.7 | -0.2 | -0.4 | -0.6 | -0.2 |
| Delta distance traveled before/after self-admin | 0.2 | 0.2 | 0.4 | -0.2 | -0.5 | -0.3 | 0.3 | -0.6 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.6 | 0.6 | 0.1 | 0.3 | 0.8 | 0.2 |
| Delay disc. indifference point, 4s delay | 0.2 | 0.2 | 0.4 | -0.3 | -0.6 | -0.6 | -0.2 | -0.6 |
| Vertical activity count, locomotor time 2 | 0.2 | 0.3 | 0.6 | 0.3 | 0.8 | 0.5 | -0.3 | 0.5 |
| Run reversals in cocaine runway, females | 0.2 | 0.2 | 0.4 | -0.3 | -0.4 | -0.4 | 0.6 | -0.6 |
| Right kidney weight | 0.1 | 0.2 | 0.4 | 0.2 | 0.5 | 0.4 | -0.4 | 0.6 |
| Parametrial fat weight | 0.1 | 0.2 | 0.6 | 0.1 | 0.8 | 0.5 | -0.3 | 0.4 |
| Retroperitoneal fat weight | 0.1 | 0.4 | 0.7 | -0.4 | -0.8 | -0.7 | 0.1 | -0.7 |
| Tibia length | 0.1 | 0.4 | 1.2 | -0.1 | 0.4 | 0.2 | -1.1 | 0.7 |
| Locomotor testing distance | 0.1 | 0.1 | 0.4 | -0.3 | 0.1 | 0.1 | -0.6 | 0.3 |
| Reaction time number correct | 0.1 | 0.1 | 0.3 | -0.4 | 0.2 | 0.0 | -0.6 | 0.1 |
| Reaction time trials correct on left | 0.1 | 0.1 | 0.3 | -0.4 | 0.2 | 0.0 | -0.6 | 0.1 |
| Reaction time trials on left | 0.1 | 0.1 | 0.4 | -0.5 | 0.0 | -0.1 | -0.6 | -0.0 |
| Reaction time trials completed | 0.1 | 0.1 | 0.4 | -0.5 | 0.0 | -0.1 | -0.6 | -0.0 |
| Reaction time trials AUC | 0.1 | 0.1 | 0.4 | -0.5 | -0.0 | -0.1 | -0.6 | -0.1 |
| Social time | 0.1 | 0.2 | 0.5 | -0.5 | -0.2 | -0.3 | -0.7 | -0.3 |
| Short access total locomotion | 0.1 | 0.1 | 0.3 | -0.5 | 0.2 | -0.1 | -0.6 | -0.2 |
| Compulsive drug intake | 0.1 | 0.1 | 0.3 | -0.1 | 0.3 | 0.2 | -0.5 | 0.3 |
| Context. condit. distance diff. score | 0.1 | 0.1 | 0.1 | -0.3 | -0.4 | -0.3 | 0.0 | -0.3 |
| Stereotopy head waving bouts, day 3 | 0.1 | 0.1 | 0.4 | 0.1 | 0.2 | 0.2 | -0.6 | 0.4 |
| Locomotion velocity, session 7 | 0.1 | 0.1 | 0.1 | -0.4 | -0.3 | -0.2 | -0.1 | -0.1 |
| Locomotion distance, session 7 | 0.1 | 0.1 | 0.3 | 0.1 | 0.5 | 0.4 | -0.1 | 0.5 |
| Total zone transitions, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.3 | -0.2 | -0.3 | -0.3 | -0.4 |
| Bone: cortical thickness | 0.1 | 0.2 | 0.3 | 0.1 | -0.6 | -0.4 | 0.4 | -0.4 |
| Bone: trabecular spacing | 0.1 | 0.1 | 0.4 | 0.5 | 0.1 | 0.2 | 0.7 | 0.1 |
| Diff in mean of infusions in LGA sessions | 0.1 | 0.1 | 0.4 | -0.1 | -0.6 | -0.4 | -0.0 | -0.2 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.4 | 0.2 | 0.1 | 0.1 | 0.6 | -0.2 |
| Delay disc. indifference point, 8s delay | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.2 | -0.2 | -0.1 |
| Locomotion in novel chamber | 0.1 | 0.1 | 0.3 | -0.1 | -0.4 | -0.3 | 0.3 | -0.6 |
| Latency to leave start box in cocaine runway, F | 0.1 | 0.1 | 0.2 | -0.4 | -0.1 | -0.2 | -0.5 | 0.1 |
| Zn content in liver | 0.1 | 0.1 | 0.6 | 0.3 | -0.2 | 0.0 | 0.7 | -0.3 |
| Liver weight, right | 0.0 | 0.1 | 0.2 | -0.2 | 0.3 | 0.2 | -0.4 | 0.1 |
| Delay discounting water rate 12 sec | 0.0 | 0.1 | 0.2 | 0.0 | 0.0 | 0.1 | -0.4 | 0.3 |
| Locomotor activity | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.2 | 0.2 | 0.2 |
| Condit. Reinf. active-inactive response ratio | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.1 | 0.3 | -0.1 |
| Stereotopy head waving duration, day 3 | 0.0 | 0.0 | 0.1 | 0.0 | -0.2 | -0.0 | -0.2 | 0.1 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.0 | 0.2 | -0.0 | -0.0 | 0.2 | 0.0 |
| Bone: minimum diameter | 0.0 | 0.1 | 0.2 | -0.2 | -0.4 | -0.3 | 0.1 | -0.4 |
| Time to tail flick, vehicle, after self-admin | 0.0 | 0.0 | 0.0 | -0.2 | 0.2 | 0.1 | -0.2 | 0.1 |
| Time >=10cm from walls, locomotor time 1 | 0.0 | 0.0 | 0.1 | 0.0 | 0.2 | 0.1 | -0.3 | 0.2 |
| Time >=10cm from walls, locomotor time 2 | 0.0 | 0.0 | 0.1 | 0.2 | 0.3 | 0.2 | -0.1 | 0.1 |
| Run reversals in cocaine runway, males | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.0 | 0.3 | -0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.