Hub : Genes

Cenpo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	ENSRNOG00000050111	0.03	0.04	6.9e-03	0.01	0.01	0.01	0.01	1.4e-02	1.3e-02	2.1e-02	1.2e-02
2	Liver	mRNA stability	ENSRNOG00000050111	0.27	0.14	3.2e-04	0.02	0.01	0.01	0	3.9e-03	1.1e-02	6.7e-03	1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	3.8	12.2	13.4	-3.7	3.3
BMI without tail	1.8	3.9	5.0	-1.6	2.2
Body weight	3.2	13.5	15.0	-3.5	3.9
Epididymis fat weight	19.4	45.3	46.8	-6.8	6.6
Glucose	0.3	0.5	0.7	-0.5	0.8
Heart weight	4.4	6.3	8.6	-2.9	2.0
Left kidney weight	0.2	0.6	1.2	1.1	-0.3
Right kidney weight	0.4	1.1	1.8	-0.5	1.4
Tail length	0.2	0.5	1.0	1.0	-0.2
Length with tail	0.1	0.5	0.9	0.1	1.0
Length without tail	0.0	0.1	0.1	0.3	0.3
Liver weight, left	2.0	3.3	4.9	-1.3	2.2
Liver weight, right	5.0	8.3	8.6	-2.8	2.9
Parametrial fat weight	14.3	28.0	33.6	-4.7	5.8
Retroperitoneal fat weight	35.7	118.1	122.1	-11.0	10.7
Intraocular pressure	2.4	3.4	4.3	-2.1	1.6
Extensor digitorum longus weight	2.3	9.1	12.7	3.6	-2.3
Soleus weight	3.8	11.0	13.2	3.6	-3.0
Tibialis anterior weight	1.3	4.3	6.2	2.5	-1.6
Tibia length	0.7	2.0	2.8	-1.1	1.7
Number of licking bursts	1.6	1.8	2.9	-0.9	1.7
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.2	-0.0
Times rat made contact with spout	1.5	1.7	2.1	1.4	-1.2
Mean time between licks in bursts	1.8	2.6	2.7	-1.6	1.6
Mean num. licks in bursts	3.2	3.8	4.9	1.6	-2.2
Std. dev. time between licks in bursts	0.6	0.7	1.2	-1.1	0.4
Water consumed over 24 hours	0.3	0.4	0.6	0.7	-0.5
Indifference point 0 sec	0.0	0.0	0.0	0.2	-0.2
Indifference point AUC	0.1	0.1	0.1	-0.2	0.3
Indifference point function ln k	3.0	4.2	5.7	2.4	-1.6
Indifference point function log k	3.0	4.2	5.7	2.4	-1.6
Delay discounting total patch changes 0 sec	0.0	0.0	0.1	0.1	-0.3
Delay discounting total patch changes 12 sec	1.5	2.0	2.7	-1.6	1.2
Delay discounting total patch changes 18 sec	0.2	0.3	0.6	-0.8	0.1
Delay discounting total patch changes 24 sec	0.5	0.6	0.7	-0.7	0.8
Delay discounting total patch changes 6 sec	0.7	1.1	1.3	-0.9	1.1
Delay discounting time to switch 0 sec	1.0	1.5	2.6	-1.6	0.7
Delay discounting water rate 0 sec	3.2	5.1	6.5	2.5	-1.9
Delay discounting water rate 12 sec	0.1	0.1	0.1	0.3	0.3
Delay discounting water rate 18 sec	2.9	3.8	4.1	2.0	-1.9
Delay discounting water rate 24 sec	0.0	0.0	0.0	0.1	0.0
Delay discounting water rate 6 sec	0.7	0.9	1.3	1.1	-0.8
Locomotor activity	1.9	3.1	5.6	-0.7	2.4
Locomotor testing distance	2.0	3.3	5.7	-0.9	2.4
Locomotor testing rearing	0.3	0.5	0.8	0.4	0.9
Light reinforcement 1	0.1	0.1	0.2	0.4	-0.2
Light reinforcement 2	2.0	2.6	4.6	0.8	-2.1
Reaction time number correct	0.3	0.5	0.5	0.7	-0.6
Reaction time mean minus median	1.4	1.8	3.2	-0.7	1.8
Reaction time mean minus median AUC	1.8	2.3	4.1	-0.8	2.0
Reaction time num false alarms	3.2	4.4	5.5	-2.3	1.8
Reaction time num false alarms AUC	2.9	4.1	5.3	-2.3	1.7
Reaction time trials correct on left	0.3	0.5	0.5	0.7	-0.6
Reaction time trials on left	0.2	0.4	0.4	0.6	-0.5
Reaction time mean	0.3	0.4	0.5	-0.7	0.6
Reaction time mean AUC	0.2	0.3	0.3	-0.6	0.5
Median of all reaction times	0.0	0.1	0.1	-0.3	-0.2
Reaction time omissions	1.4	1.9	3.3	-0.7	1.8
Reaction time false alarm rate	3.3	4.7	6.1	-2.5	1.8
Reaction time premature initiation rate	0.1	0.1	0.2	-0.1	-0.4
Reaction time premature initiations	0.2	0.4	0.6	0.3	-0.8
Std. dev. reaction times	1.7	2.3	3.2	-1.1	1.8
Reaction time trials completed	0.2	0.4	0.4	0.6	-0.5
Reaction time trials AUC	0.2	0.3	0.4	0.6	-0.5
Social response proportion	0.2	0.2	0.2	0.5	-0.4
Social responses	0.4	0.5	0.9	0.2	1.0
Social time	0.0	0.0	0.0	0.2	-0.2
Conditioned locomotion	1.6	1.9	1.9	1.4	-1.4
Cocaine response after cond. corrected	0.1	0.1	0.3	0.5	0.1
Cocaine response after cond. not corrected	0.8	0.9	1.7	1.3	-0.4
Cocaine response before conditioning	1.8	2.2	2.5	1.6	-1.4
Saline control response	1.9	2.5	2.5	1.6	-1.6
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.8	-0.0
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.2	-0.0
Condit. Reinf. lever presses	0.7	1.0	1.3	1.1	-0.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. lever latency	0.5	0.7	0.9	-0.8	0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.0	0.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. index score	0.4	0.6	0.6	0.8	-0.7
Pavlov. Cond. latency score	0.5	0.6	0.7	0.8	-0.8
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.1	-0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	0.5	-0.3
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	-1.3	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.3	0.5	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	0.3	-0.4
Conditioned reinforcement - actives	4.2	4.2	4.7	1.9	-2.2
Conditioned reinforcement - inactives	6.6	7.5	8.9	3.0	-2.5
Conditioned locomotion	6.0	7.2	7.7	2.6	-2.8
Intermittent access intake day 1-15 change	4.4	4.4	6.4	1.5	-2.5
Intermittent access intake escalation	3.2	3.1	4.8	1.2	-2.2
Intermittent access intake escalation 2	0.7	0.7	1.4	0.2	-1.2
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.6	0.4
Intermitt. access day 15 inactive lever presses	0.4	0.5	0.9	0.9	-0.3
Intermitt. access escalation Index	3.2	2.9	5.0	-2.2	0.9
Intermittent access day 1 total infusions	1.1	1.3	1.3	1.1	-1.1
Intermittent access day 15 total infusions	2.9	3.3	4.5	1.4	-2.1
Intermittent access terminal intake (last 3 days)	2.9	3.1	4.3	1.4	-2.1
Intermittent access total infusions	2.4	2.6	2.7	1.7	-1.6
Intermittent access day 1 locomotion	2.1	2.2	2.9	1.2	-1.7
Intermittent access day 15 total locomotion	0.6	0.6	1.0	0.5	-1.0
Intermittent access total locomotion	1.1	1.2	1.8	0.8	-1.3
Intermittent access standard deviation	0.4	0.4	0.7	0.4	-0.8
Cocaine induced anxiety	0.8	1.0	1.4	0.7	-1.2
Post-drug Anxiety	0.2	0.2	0.2	-0.4	0.4
Baseline Anxiety	1.7	1.8	1.9	-1.4	1.3
Lifetime Intake	2.8	3.1	3.4	1.9	-1.7
Incentive Sensitization - Responses	2.2	2.2	3.4	1.0	-1.8
Incentive Sensitization - Breakpoint	1.6	1.6	2.8	0.7	-1.7
Progressive ratio test 1 active lever presses	0.9	0.9	1.6	1.3	-0.4
Progressive ratio test 1 breakpoint	0.8	0.8	1.3	1.2	-0.5
Progressive ratio test 1 inactive lever presses	2.0	2.1	2.6	1.6	-1.3
Progressive ratio test 2 active lever presses	2.1	2.3	2.6	1.4	-1.6
Progressive ratio test 2 breakpoint	2.2	2.4	2.9	1.4	-1.7
Progressive ratio test 2 inactive lever presses	3.5	4.1	4.3	2.0	-2.1
Total sessions with >9 infusions	4.5	4.9	6.5	2.5	-1.8
Short access day 1 total inactive lever presses	1.8	2.0	2.5	1.6	-1.3
Short access day 10 total inactive lever presses	0.6	0.7	1.4	-0.2	1.2
Short access day 1 total infusions	2.1	2.3	2.7	1.7	-1.3
Short access day 10 total infusions	2.7	2.9	3.1	1.7	-1.8
Short access total infusions	2.2	2.4	3.1	1.8	-1.3
Short access day 1 locomotion	3.5	3.7	4.8	2.2	-1.6
Short access day 10 total locomotion	1.3	1.4	1.7	1.1	-1.3
Short access total locomotion	2.8	2.9	3.1	1.6	-1.8
Compulsive drug intake	1.6	1.6	2.5	-1.6	0.8
One hour access (0.3 mA shock)	4.2	4.9	5.4	2.1	-2.3
One hour access (shock baseline)	5.1	5.9	6.6	2.6	-2.3
Number of responses in last shaping day	1.8	1.8	1.9	1.3	-1.4
Context. condit. distance diff. score	0.2	0.2	0.3	0.4	-0.6
Locomotion velocity, session 1	0.2	0.2	0.4	-0.1	0.6
Locomotion distance, session 1	0.7	0.9	1.5	1.2	-0.4
Locomotion velocity, session 2	0.2	0.2	0.3	-0.4	0.5
Locomotion distance, session 2	0.0	0.0	0.0	-0.1	0.2
Locomotion velocity, session 3	0.1	0.1	0.2	0.5	0.1
Locomotion distance, session 3	0.0	0.0	0.0	0.2	0.0
Stereotopy head waving bouts, day 3	3.1	3.7	3.9	1.9	-2.0
Stereotopy head waving duration, day 3	0.6	0.7	0.7	0.8	-0.9
Locomotion velocity, session 7	0.0	0.0	0.0	-0.2	-0.1
Locomotion distance, session 7	1.0	1.3	2.1	-1.4	0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	0.4	0.0
Stereotopy head waving duration, day 7	0.3	0.4	0.7	0.8	-0.4
Locomotion velocity, session 8	1.1	1.3	1.9	1.4	-0.8
Locomotion distance, session 8	0.8	1.2	1.6	0.9	-1.3
Degree of sensitization distance	2.0	2.0	3.0	-1.7	1.1
Degree of sensitization stereotypy	0.4	0.5	0.6	-0.6	0.8
Condit. Reinf. active minus inactive responses	3.2	3.6	3.8	-1.8	2.0
Condit. Reinf. active-inactive response ratio	2.2	2.4	2.5	-1.5	1.6
Condit. Reinf. active responses	0.6	0.7	0.7	-0.8	0.9
Condit. Reinf. inactive responses	1.0	1.2	1.2	1.1	-1.1
Incentive salience index mean	1.0	1.2	1.8	-0.8	1.4
Condit. Reinf. lever presses	0.2	0.3	0.7	0.8	-0.0
Time in familiar zone, hab. session 1	1.5	1.4	1.6	-1.3	1.1
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	0.3
Total zone transitions, hab. session 1	0.3	0.5	0.8	0.9	-0.4
Total locomotion distance, hab. session 1	1.1	1.6	2.5	1.6	-0.8
Locomotion velocity, hab. session 1	1.9	2.7	3.8	1.9	-1.3
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.2	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.5	-0.7	0.4
Total zone transitions, hab. session 2	0.3	0.3	0.7	0.8	-0.0
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.6	0.1
Locomotion velocity, hab. session 2	0.2	0.3	0.6	0.8	0.1
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.3	-0.1
Novelty place preference	0.2	0.2	0.3	-0.5	0.3
Time in novel zone, NPP test	0.2	0.2	0.4	-0.6	0.2
Total zone transitions, NPP test	0.5	0.7	1.3	1.1	-0.4
Total locomotion distance, NPP test	1.3	1.8	2.6	1.6	-1.0
Locomotion velocity, NPP test	1.8	2.6	4.1	2.0	-1.1
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.7	0.1
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.0	0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. index score	0.0	0.1	0.1	0.3	0.1
Pavlov. Cond. latency score	0.1	0.1	0.1	0.4	0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.7	0.8	-0.1
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.5	-0.2
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	0.7	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	0.7	-0.3
Pavlov. Cond. response bias	0.7	0.8	1.3	1.2	-0.5
Bone: apparent density	5.1	8.4	12.1	3.5	-2.2
Bone surface	1.8	3.2	4.5	2.1	-1.4
Bone volume	3.4	5.7	7.6	2.8	-2.0
Bone: connectivity density	3.4	5.3	8.0	2.8	-1.6
Bone: cortical apparent density	0.1	0.1	0.1	0.3	-0.3
Bone: cortical area	0.1	0.2	0.2	-0.4	0.4
Bone: cortical porosity	2.5	2.7	3.3	1.8	-1.5
Bone: cortical porosity	2.1	2.2	2.8	1.7	-1.3
Bone: cortical thickness	0.2	0.3	0.4	-0.4	0.6
Bone: cortical thickness	0.5	0.5	0.8	0.5	-0.9
Bone: cortical tissue density	0.0	0.1	0.1	0.3	-0.2
Bone: elastic displacement	2.1	2.4	3.3	1.8	-1.2
Bone: elastic work	1.3	1.7	1.9	1.4	-1.2
Bone: endosteal estimation	0.1	0.3	0.4	0.4	-0.6
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	0.1
Bone: final force	0.1	0.1	0.1	0.2	0.4
Bone: final moment	0.0	0.1	0.1	0.3	0.3
Bone: marrow area	0.1	0.3	0.4	0.4	-0.7
Bone: maximum diameter	0.0	0.0	0.0	0.1	-0.2
Bone: maximum force	0.0	0.0	0.1	-0.1	0.2
Bone: maximum moment	0.0	0.0	0.0	0.0	0.1
Bone: minimum diameter	1.2	2.2	2.7	-1.6	1.3
Bone: periosteal estimation	0.0	0.1	0.2	0.2	-0.4
Bone: periosteal perimeter	0.0	0.1	0.1	-0.3	0.2
Bone: post-yield work	1.0	1.4	1.8	1.3	-1.0
Bone: stiffness	0.2	0.3	0.5	-0.7	0.4
Bone: tissue strength	0.2	0.2	0.3	0.1	0.6
Bone: trabecular number	4.9	7.7	11.0	3.3	-2.1
Bone: trabecular spacing	1.1	1.5	2.2	-1.5	0.8
Bone: trabecular thickness	0.1	0.1	0.2	0.5	-0.3
Bone: trabecular tissue density	0.2	0.3	0.6	-0.8	-0.2
Breakpoint value in progressive ratio session	1.5	1.7	1.8	1.3	-1.3
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.1
Distance traveled after self-admin	0.0	0.1	0.1	-0.3	0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.7	0.5
Delta time in open arm before/after self-admin	0.2	0.2	0.4	0.3	0.6
Diff in mean of infusions in LGA sessions	0.3	0.4	0.7	-0.1	0.9
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.2	0.0
Active lever presses in extinction session 6	1.6	1.5	2.7	1.6	0.6
Delta distance traveled before/after self-admin	0.9	0.9	1.5	-0.6	1.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.3	0.1
Time in closed arm before self-admin	0.0	0.0	0.1	0.2	-0.0
Time in closed arm after self-admin	0.7	0.8	1.4	-0.3	1.2
Time in open arm before self-admin	0.2	0.2	0.4	-0.7	-0.1
Time in open arm after self-admin	0.1	0.1	0.3	-0.0	-0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.1
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.4	-0.3	1.5
Time to tail flick, vehicle, after self-admin	7.6	8.2	9.9	-2.5	3.1
Time to tail flick, test, before self-admin	1.4	1.4	1.4	1.2	-1.2
Time to tail flick, test, after self-admin	1.2	1.2	1.6	1.3	-1.0
Delta time to tail flick, vehicle, before/after SA	2.1	2.1	2.9	-1.7	1.1
Delta time to tail flick, test, before/after SA	1.9	1.7	2.2	1.1	-1.5
Ambulatory time before self-admin	0.2	0.2	0.3	-0.6	0.2
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	0.2
Total heroin consumption	3.1	3.8	4.5	1.7	-2.1
Area under the delay curve	0.1	0.2	0.3	-0.6	-0.1
Delay disc. indifference point, 0s delay	0.4	0.4	0.8	-0.9	0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.5	-0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.2	-0.3
Delay disc. indifference point, 24s delay	2.7	2.6	3.5	1.9	-1.3
Delay disc. indifference point, 4s delay	0.5	0.5	0.9	-1.0	-0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	-0.1
Delay discount exponential model param	0.1	0.1	0.1	0.3	0.2
Delay discount hyperbolic model param	0.1	0.1	0.1	0.4	0.3
Fecal boli incidents, locomotor time 1	3.3	3.6	4.7	1.6	-2.2
Change in fecal boli incidents, locomotor task	3.4	3.2	4.7	-2.2	1.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	0.0	-0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.0	-0.6
Total resting periods, locomotor time 1	0.3	0.3	0.6	0.0	-0.7
Rest time, locomotor task time 1	0.2	0.2	0.4	0.1	-0.6
Distance moved, locomotor task time 1	0.5	0.6	1.2	-0.1	1.1
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.1	0.2
Time >=10cm from walls, locomotor time 2	1.6	1.6	2.1	1.1	-1.5
Bouts of movement, locomotor time 2	0.8	0.9	1.7	-1.3	-0.1
Total resting periods, locomotor time 2	0.8	0.9	1.7	-1.3	-0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.1	-0.2
Distance moved, locomotor task time 2	0.3	0.3	0.6	0.8	0.0
Vertical activity count, locomotor time 2	0.6	0.6	1.1	1.1	-0.4
Weight adjusted by age	2.0	2.3	2.5	-1.6	1.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.4	-0.6	0.6
Locomotion in novel chamber	1.1	1.3	2.5	-0.5	1.6
Locomotion in novel chamber post-restriction	1.5	1.8	3.3	-1.8	0.5
Progressive ratio	0.0	0.0	0.1	0.2	0.1
Food seeking constrained by brief footshock	8.4	10.3	11.7	3.4	-3.0
Seeking ratio, punishment vs. effort	1.4	1.7	2.2	1.2	-1.5
Run reversals in cocaine runway, females	0.7	0.7	1.2	0.5	-1.1
Run reversals in cocaine runway, males	1.1	1.1	1.6	1.3	-0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.1	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.3	0.3
Latency to leave start box in cocaine runway, M	1.2	1.1	1.4	0.9	-1.2
Cd content in liver	0.1	0.1	0.2	-0.5	-0.1
Co content in liver	2.0	2.3	2.7	1.4	-1.6
Cu content in liver	0.9	1.1	1.4	-1.2	0.9
Fe content in liver	0.2	0.3	0.5	0.2	-0.7
K content in liver	2.6	2.6	2.7	-1.6	1.6
Mg content in liver	1.3	1.3	1.8	-1.3	0.9
Mn content in liver	0.1	0.1	0.2	-0.4	-0.2
Na content in liver	4.5	4.8	7.1	2.7	-1.6
Rb content in liver	0.8	1.0	1.0	-1.0	0.9
Se content in liver	0.7	0.9	1.3	-1.1	0.7
Sr content in liver	0.1	0.1	0.1	-0.3	-0.2
Zn content in liver	5.5	6.1	6.8	-2.3	2.6