Hub : Genes

Rcor1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	ENSRNOG00000049783	0.05	0.05	6.7e-04	0.04	0.03	0.02	0.03	1.2e-03	2e-03	2.0e-02	2.1e-03
2	PL	mRNA stability	ENSRNOG00000049783	0.04	0.04	4.9e-03	0.01	0.01	0.02	0.01	3.6e-02	8e-02	6.2e-03	8.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	1.7	5.6	9.9	-3.1	1.2
BMI without tail	0.3	0.6	0.9	-1.0	0.5
Body weight	0.1	0.6	0.9	0.6	-1.0
Epididymis fat weight	3.0	7.1	10.2	-3.2	2.0
Glucose	0.8	1.3	1.5	1.0	-1.2
Heart weight	0.0	0.0	0.0	0.0	0.0
Left kidney weight	0.4	1.1	1.3	1.2	-0.9
Right kidney weight	0.2	0.5	0.6	0.8	-0.7
Tail length	2.3	7.0	11.5	3.4	-1.6
Length with tail	3.0	10.9	16.6	4.1	-2.3
Length without tail	1.2	2.7	3.2	1.8	-1.5
Liver weight, left	3.0	4.8	7.0	2.6	-1.6
Liver weight, right	0.0	0.1	0.1	0.1	-0.4
Parametrial fat weight	0.0	0.1	0.1	0.2	-0.3
Retroperitoneal fat weight	0.1	0.2	0.4	-0.7	0.1
Intraocular pressure	0.0	0.0	0.1	-0.3	0.1
Extensor digitorum longus weight	4.5	18.1	23.8	4.9	-3.5
Soleus weight	0.1	0.2	0.4	-0.2	0.7
Tibialis anterior weight	0.2	0.8	1.2	1.1	-0.5
Tibia length	1.0	2.9	3.9	1.4	-2.0
Number of licking bursts	0.3	0.3	0.5	0.4	-0.7
Food consumed during 24 hour testing period	0.2	0.2	0.2	0.4	-0.5
Times rat made contact with spout	0.3	0.4	0.5	0.4	-0.7
Mean time between licks in bursts	0.6	0.8	1.2	-1.1	0.6
Mean num. licks in bursts	0.1	0.1	0.2	-0.1	0.4
Std. dev. time between licks in bursts	0.3	0.4	0.6	-0.8	0.4
Water consumed over 24 hours	2.7	3.2	3.3	1.8	-1.8
Indifference point 0 sec	2.3	3.8	4.7	2.2	-1.7
Indifference point AUC	1.1	1.3	2.1	1.5	-0.6
Indifference point function ln k	0.7	1.0	1.2	0.9	-1.1
Indifference point function log k	0.7	1.0	1.2	0.9	-1.1
Delay discounting total patch changes 0 sec	2.5	4.1	5.1	2.2	-1.8
Delay discounting total patch changes 12 sec	1.5	2.0	3.1	1.8	-0.9
Delay discounting total patch changes 18 sec	0.4	0.5	0.8	0.9	-0.4
Delay discounting total patch changes 24 sec	0.0	0.0	0.1	0.3	0.0
Delay discounting total patch changes 6 sec	0.9	1.3	2.0	1.4	-0.9
Delay discounting time to switch 0 sec	7.9	12.0	17.3	-4.2	2.6
Delay discounting water rate 0 sec	13.8	21.9	29.7	5.4	-3.8
Delay discounting water rate 12 sec	7.4	11.1	14.9	3.9	-2.7
Delay discounting water rate 18 sec	5.1	6.8	8.2	2.9	-2.3
Delay discounting water rate 24 sec	3.6	5.0	6.8	2.6	-1.8
Delay discounting water rate 6 sec	3.1	4.5	6.9	2.6	-1.4
Locomotor activity	0.1	0.1	0.2	0.3	-0.4
Locomotor testing distance	0.2	0.3	0.4	0.6	-0.4
Locomotor testing rearing	1.9	2.9	3.0	-1.7	1.7
Light reinforcement 1	0.1	0.1	0.1	-0.4	0.3
Light reinforcement 2	0.5	0.7	1.3	-1.1	0.2
Reaction time number correct	1.9	2.7	2.9	1.7	-1.6
Reaction time mean minus median	0.0	0.0	0.1	-0.2	-0.0
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.2	-0.1
Reaction time num false alarms	0.6	0.9	1.0	0.9	-1.0
Reaction time num false alarms AUC	1.1	1.5	1.6	1.3	-1.2
Reaction time trials correct on left	1.9	2.7	2.9	1.7	-1.6
Reaction time trials on left	1.9	2.7	2.9	1.7	-1.6
Reaction time mean	1.1	1.5	1.9	-1.1	1.4
Reaction time mean AUC	0.7	0.9	1.2	-0.8	1.1
Median of all reaction times	1.1	1.5	2.1	-0.9	1.5
Reaction time omissions	0.5	0.7	1.4	1.2	-0.1
Reaction time false alarm rate	0.1	0.2	0.2	0.4	-0.4
Reaction time premature initiation rate	0.3	0.5	0.6	0.8	-0.6
Reaction time premature initiations	1.2	1.7	2.2	1.5	-1.1
Std. dev. reaction times	0.2	0.2	0.2	-0.5	0.5
Reaction time trials completed	1.9	2.7	2.9	1.7	-1.6
Reaction time trials AUC	1.9	2.7	3.0	1.7	-1.5
Social response proportion	0.1	0.1	0.2	0.4	-0.2
Social responses	0.2	0.3	0.5	-0.2	0.7
Social time	0.5	0.7	0.8	0.9	-0.8
Conditioned locomotion	0.7	0.8	1.2	1.1	-0.7
Cocaine response after cond. corrected	0.4	0.5	0.5	-0.7	0.7
Cocaine response after cond. not corrected	1.6	1.8	2.0	-1.4	1.2
Cocaine response before conditioning	1.8	2.1	3.3	-1.8	1.0
Saline control response	0.1	0.1	0.2	-0.5	0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.5	-0.0
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	0.5	-0.7
Condit. Reinf. active responses	0.2	0.2	0.4	-0.3	0.6
Condit. Reinf. inactive responses	0.7	0.8	0.8	-0.9	0.9
Condit. Reinf. lever presses	2.3	3.2	3.9	-1.6	2.0
Condit. Reinf. lever reinforcers received	0.2	0.2	0.3	-0.3	0.6
Pavlov. Cond. lever latency	3.2	4.4	5.7	1.7	-2.4
Pavlov. Cond. magazine entry latency	3.5	4.0	5.8	-2.4	1.5
Pavlov. Cond. change in total contacts	3.6	5.0	6.2	-2.5	1.9
Pavlov. Cond. index score	4.9	6.4	7.1	-2.7	2.4
Pavlov. Cond. latency score	4.8	6.0	6.6	-2.6	2.3
Pavlov. Cond. lever contacts	4.4	6.1	8.1	-2.0	2.9
Pavlov. Cond. magazine entry number	3.1	3.8	5.6	2.4	-1.4
Pavlov. Cond. intertrial magazine entries	2.9	3.7	5.5	2.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.8	8.0	-2.8	2.4
Pavlov. Cond. response bias	4.7	6.5	7.2	-2.4	2.7
Conditioned reinforcement - actives	1.2	1.2	1.9	1.4	-0.7
Conditioned reinforcement - inactives	0.2	0.2	0.4	0.6	0.2
Conditioned locomotion	0.8	0.9	1.1	-0.9	1.0
Intermittent access intake day 1-15 change	1.5	1.5	1.6	-1.1	1.3
Intermittent access intake escalation	1.8	1.7	2.0	-1.2	1.4
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.2	0.5
Intermitt. access day 1 inactive lever presses	2.2	2.3	2.9	1.7	-1.3
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	0.8	-0.4
Intermitt. access escalation Index	0.6	0.6	0.9	0.4	-1.0
Intermittent access day 1 total infusions	0.4	0.5	0.6	-0.7	0.6
Intermittent access day 15 total infusions	2.1	2.3	2.4	-1.5	1.6
Intermittent access terminal intake (last 3 days)	2.4	2.6	2.7	-1.6	1.6
Intermittent access total infusions	0.9	1.0	1.0	-1.0	1.0
Intermittent access day 1 locomotion	0.7	0.8	1.0	-1.0	0.7
Intermittent access day 15 total locomotion	0.5	0.5	0.7	-0.6	0.8
Intermittent access total locomotion	0.6	0.6	0.8	-0.7	0.9
Intermittent access standard deviation	3.0	3.2	3.6	-1.9	1.7
Cocaine induced anxiety	2.1	2.5	3.5	1.9	-1.2
Post-drug Anxiety	2.0	2.2	2.8	1.7	-1.3
Baseline Anxiety	1.1	1.2	1.7	-1.3	0.8
Lifetime Intake	0.6	0.7	0.9	-0.7	0.9
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.2	0.4
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.1	0.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.2	0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.4	0.5
Progressive ratio test 1 inactive lever presses	1.7	1.8	3.0	1.7	-0.8
Progressive ratio test 2 active lever presses	0.2	0.3	0.5	-0.2	0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.2	0.6
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.8	0.9	0.0
Total sessions with >9 infusions	0.5	0.5	1.0	-0.3	1.0
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.4	0.5
Short access day 10 total inactive lever presses	0.4	0.5	0.5	0.6	-0.7
Short access day 1 total infusions	0.1	0.1	0.1	0.4	-0.0
Short access day 10 total infusions	0.4	0.4	0.6	-0.8	0.5
Short access total infusions	0.4	0.5	0.6	-0.6	0.8
Short access day 1 locomotion	0.8	0.9	0.9	-1.0	0.9
Short access day 10 total locomotion	0.5	0.5	0.6	-0.8	0.6
Short access total locomotion	0.1	0.1	0.1	-0.3	0.3
Compulsive drug intake	0.1	0.1	0.1	-0.2	0.3
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.2	0.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	0.1
Number of responses in last shaping day	0.2	0.2	0.3	-0.5	0.4
Context. condit. distance diff. score	1.3	1.5	2.3	1.5	-0.9
Locomotion velocity, session 1	0.2	0.2	0.4	0.6	0.1
Locomotion distance, session 1	1.1	1.4	2.6	-0.5	1.6
Locomotion velocity, session 2	0.5	0.5	1.0	-0.3	1.0
Locomotion distance, session 2	0.6	0.9	1.5	-0.5	1.2
Locomotion velocity, session 3	0.1	0.1	0.2	-0.5	-0.0
Locomotion distance, session 3	0.1	0.2	0.2	0.3	-0.5
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	0.3	-0.5
Stereotopy head waving duration, day 3	0.0	0.1	0.1	0.3	-0.0
Locomotion velocity, session 7	0.3	0.3	0.5	-0.7	0.5
Locomotion distance, session 7	0.7	0.9	1.1	-1.0	0.9
Stereotopy head waving bouts, day 7	0.8	0.9	1.0	0.9	-1.0
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.4	-0.8
Locomotion velocity, session 8	0.1	0.1	0.1	0.4	0.1
Locomotion distance, session 8	0.2	0.2	0.5	0.0	0.7
Degree of sensitization distance	0.2	0.2	0.3	-0.5	0.4
Degree of sensitization stereotypy	0.2	0.3	0.3	0.4	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.6	0.1
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.4	-1.5	0.8
Condit. Reinf. active responses	0.2	0.2	0.2	-0.4	0.5
Condit. Reinf. inactive responses	0.8	1.0	1.8	1.4	-0.3
Incentive salience index mean	0.2	0.2	0.4	-0.6	0.3
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	0.3
Time in familiar zone, hab. session 1	1.8	1.7	2.1	-1.1	1.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.1	-0.5
Total zone transitions, hab. session 1	0.5	0.7	0.9	-0.7	0.9
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.2	0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.6	0.8	-0.1
Time in familiar zone, hab. session 2	1.1	1.1	1.4	-1.2	0.9
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.3	-0.0
Total zone transitions, hab. session 2	0.9	1.1	1.7	-0.7	1.3
Total locomotion distance, hab. session 2	0.4	0.5	0.9	1.0	0.2
Locomotion velocity, hab. session 2	0.5	0.6	1.2	1.1	-0.0
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.3	0.3
Novelty place preference	0.1	0.1	0.1	-0.3	0.3
Time in novel zone, NPP test	0.0	0.0	0.0	-0.2	0.2
Total zone transitions, NPP test	0.5	0.7	1.4	-0.2	1.2
Total locomotion distance, NPP test	0.1	0.2	0.3	0.6	0.1
Locomotion velocity, NPP test	0.1	0.2	0.4	0.6	0.2
Pavlov. Cond. lever latency	0.8	1.0	1.2	0.9	-1.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	-0.8	0.4
Pavlov. Cond. change in total contacts	1.1	1.2	1.9	-0.7	1.4
Pavlov. Cond. index score	0.9	1.1	1.3	-1.0	1.1
Pavlov. Cond. latency score	0.7	0.9	1.2	-0.8	1.1
Pavlov. Cond. lever contacts	1.0	1.2	1.4	-1.0	1.2
Pavlov. Cond. magazine entry number	1.0	1.2	1.4	1.2	-1.0
Pavlov. Cond. intertrial magazine entries	5.3	6.4	6.8	2.6	-2.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	0.9	-0.8	1.0
Pavlov. Cond. response bias	1.0	1.2	1.5	-1.2	1.0
Bone: apparent density	0.0	0.0	0.0	-0.1	0.1
Bone surface	0.0	0.0	0.0	-0.0	0.2
Bone volume	0.0	0.0	0.1	-0.1	0.3
Bone: connectivity density	0.0	0.0	0.1	0.2	0.2
Bone: cortical apparent density	7.5	9.7	10.8	3.3	-2.9
Bone: cortical area	2.2	3.3	3.5	1.8	-1.9
Bone: cortical porosity	0.1	0.1	0.1	0.0	-0.3
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.2
Bone: cortical thickness	1.6	2.6	3.1	1.7	-1.5
Bone: cortical thickness	2.2	2.6	3.4	1.3	-1.8
Bone: cortical tissue density	7.3	9.5	10.8	3.3	-2.9
Bone: elastic displacement	1.5	1.7	2.2	1.1	-1.5
Bone: elastic work	0.6	0.8	1.0	0.8	-1.0
Bone: endosteal estimation	0.1	0.2	0.4	-0.6	0.0
Bone: endosteal perimeter	0.0	0.0	0.0	0.2	-0.1
Bone: final force	1.0	1.6	1.9	1.1	-1.4
Bone: final moment	1.1	1.8	2.0	1.2	-1.4
Bone: marrow area	0.1	0.2	0.3	-0.5	-0.1
Bone: maximum diameter	0.4	0.7	1.0	0.6	-1.0
Bone: maximum force	0.9	1.6	2.1	1.1	-1.5
Bone: maximum moment	0.9	1.6	2.0	1.1	-1.4
Bone: minimum diameter	1.0	1.8	2.1	1.2	-1.5
Bone: periosteal estimation	0.5	0.9	1.2	0.8	-1.1
Bone: periosteal perimeter	0.2	0.3	0.5	0.7	-0.4
Bone: post-yield work	1.0	1.4	1.5	1.2	-1.1
Bone: stiffness	2.3	3.7	3.8	2.0	-1.9
Bone: tissue strength	0.7	0.7	1.1	0.6	-1.0
Bone: trabecular number	0.0	0.0	0.0	0.2	-0.1
Bone: trabecular spacing	0.1	0.1	0.2	0.0	-0.5
Bone: trabecular thickness	0.0	0.1	0.1	0.3	0.0
Bone: trabecular tissue density	0.4	0.6	1.1	0.3	-1.0
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.0	0.3
Distance traveled before self-admin	0.1	0.1	0.1	-0.1	0.4
Distance traveled after self-admin	0.6	0.6	0.7	0.8	-0.8
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.2	0.2
Delta time in open arm before/after self-admin	0.5	0.5	0.7	0.6	-0.8
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.2	0.2
Extinction: sum of active levers before priming	0.3	0.3	0.5	-0.0	0.7
Active lever presses in extinction session 6	0.9	0.8	1.5	1.2	-0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.2	-0.3
Delta ambulatory time before/after self-admin	0.5	0.6	0.6	0.8	-0.7
Time in closed arm before self-admin	2.0	2.3	3.3	-1.8	1.1
Time in closed arm after self-admin	1.2	1.3	1.8	-1.3	0.9
Time in open arm before self-admin	3.8	4.0	5.2	2.3	-1.7
Time in open arm after self-admin	2.6	2.9	3.0	1.7	-1.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	0.3
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.9	0.9	-0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.2	-0.5	0.4
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.1	0.6
Time to tail flick, test, after self-admin	1.8	1.8	1.9	1.3	-1.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.3
Delta time to tail flick, test, before/after SA	2.0	1.8	2.5	1.1	-1.6
Ambulatory time before self-admin	0.1	0.1	0.2	-0.3	0.4
Ambulatory time after self-admin	0.0	0.0	0.0	-0.0	0.0
Total heroin consumption	0.9	1.1	1.7	1.3	-0.7
Area under the delay curve	0.2	0.2	0.4	-0.6	-0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.0	-0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.2	-0.4
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	-0.1	-0.9
Delay disc. indifference point, 8s delay	0.5	0.5	0.8	-0.9	-0.3
Delay discount exponential model param	0.2	0.2	0.3	0.6	0.3
Delay discount hyperbolic model param	0.2	0.2	0.3	0.6	0.3
Fecal boli incidents, locomotor time 1	1.1	1.2	1.4	-1.2	1.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	-0.8	-0.1
Bouts of movement, locomotor time 1	0.5	0.6	0.7	-0.8	0.7
Total resting periods, locomotor time 1	0.6	0.7	0.8	-0.9	0.8
Rest time, locomotor task time 1	0.2	0.3	0.3	0.4	-0.6
Distance moved, locomotor task time 1	0.5	0.5	0.7	-0.5	0.9
Vertical activity count, locomotor time 1	0.5	0.5	0.7	0.9	-0.5
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.5	0.7	-0.7
Bouts of movement, locomotor time 2	1.8	1.9	2.6	1.6	-1.1
Total resting periods, locomotor time 2	1.5	1.6	1.8	1.3	-1.2
Rest time, locomotor task time 2	1.3	1.5	2.5	0.7	-1.6
Distance moved, locomotor task time 2	0.7	0.9	1.4	-0.5	1.2
Vertical activity count, locomotor time 2	0.3	0.3	0.6	0.8	0.2
Weight adjusted by age	0.3	0.4	0.8	0.1	-0.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.5	-0.1
Locomotion in novel chamber	4.7	5.8	7.1	2.7	-2.1
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	0.0	-0.1
Progressive ratio	0.4	0.5	0.6	0.7	-0.7
Food seeking constrained by brief footshock	1.5	1.8	3.0	1.7	-0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	0.1
Run reversals in cocaine runway, females	0.7	0.7	1.3	-1.2	0.2
Run reversals in cocaine runway, males	0.6	0.6	0.9	1.0	-0.5
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.6	0.3
Latency to leave start box in cocaine runway, F	0.5	0.5	0.6	-0.7	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	-0.2
Cd content in liver	0.3	0.4	0.7	0.9	0.1
Co content in liver	0.4	0.4	0.8	0.9	0.2
Cu content in liver	0.5	0.6	1.1	-1.0	0.3
Fe content in liver	0.0	0.0	0.1	-0.3	-0.0
K content in liver	0.0	0.0	0.0	0.2	-0.2
Mg content in liver	0.0	0.0	0.0	0.0	0.2
Mn content in liver	0.2	0.2	0.4	-0.1	-0.7
Na content in liver	0.0	0.0	0.1	-0.1	-0.3
Rb content in liver	0.3	0.4	0.5	0.7	-0.6
Se content in liver	0.0	0.0	0.1	0.1	-0.3
Sr content in liver	0.3	0.3	0.5	0.7	-0.1
Zn content in liver	0.2	0.2	0.3	0.5	0.4