Hub : Genes

Fam228b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA ENSRNOT00000113530 0.04 0.03 2.6e-03 0.03 0.01 0.01 0.02 8.2e-04 3.8e-02 2.1e-02 2.8e-03
2 Liver alternative polyA ENSRNOT00000114842 0.04 0.03 6.4e-05 0.03 0.02 0.02 0.03 3.0e-04 2.9e-03 9.8e-04 8.4e-04
3 Liver alternative polyA ENSRNOT00000114842 0.04 0.02 6.8e-05 0.02 0.02 0.03 0.01 1.7e-03 4.1e-03 7.0e-04 1.0e-02
4 Liver gene expression ENSRNOG00000049615 0.19 0.08 1.7e-16 0.11 0.09 0.1 0.09 1.8e-12 4.2e-10 1.2e-10 2.5e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail3.110.011.13.3-3.3-2.7-3.3
BMI without tail2.65.58.82.0-2.0-3.0-2.2
Body weight3.012.615.03.7-3.7-2.9-3.9
Epididymis fat weight16.638.845.26.7-6.7-4.6-6.6
Glucose0.30.40.70.5-0.5-0.5-0.8
Heart weight3.04.34.52.1-2.1-2.0-2.0
Left kidney weight0.00.10.2-0.30.3-0.40.3
Right kidney weight0.51.61.81.2-1.2-1.3-1.4
Tail length0.10.31.0-0.30.3-1.00.2
Length with tail0.20.80.90.9-0.9-0.9-1.0
Length without tail0.10.20.60.3-0.30.8-0.3
Liver weight, left3.04.86.81.9-1.9-2.6-2.2
Liver weight, right5.08.38.93.0-3.0-2.6-2.9
Parametrial fat weight14.929.133.65.7-5.7-4.3-5.8
Retroperitoneal fat weight31.0102.5114.110.5-10.5-8.6-10.7
Intraocular pressure1.82.53.11.8-1.8-1.1-1.6
Extensor digitorum longus weight1.24.65.7-2.42.41.32.3
Soleus weight2.98.59.6-3.13.12.52.9
Tibialis anterior weight0.62.02.5-1.61.60.71.6
Tibia length1.13.13.31.8-1.8-1.8-1.7
Number of licking bursts2.22.73.01.7-1.7-1.4-1.7
Food consumed during 24 hour testing period0.30.41.5-0.10.1-1.20.1
Times rat made contact with spout1.21.41.7-1.31.30.91.2
Mean time between licks in bursts2.43.45.51.7-1.7-2.4-1.6
Mean num. licks in bursts3.84.65.3-2.32.31.72.2
Std. dev. time between licks in bursts0.10.10.20.4-0.40.0-0.3
Water consumed over 24 hours0.20.30.4-0.60.60.10.5
Indifference point 0 sec0.00.00.00.1-0.1-0.10.2
Indifference point AUC0.10.10.30.2-0.2-0.6-0.3
Indifference point function ln k1.82.52.7-1.61.61.61.6
Indifference point function log k1.82.52.7-1.61.61.61.6
Delay discounting total patch changes 0 sec0.00.00.1-0.10.10.00.3
Delay discounting total patch changes 12 sec1.21.51.81.4-1.4-1.1-1.2
Delay discounting total patch changes 18 sec0.30.41.40.4-0.4-1.2-0.1
Delay discounting total patch changes 24 sec0.60.80.91.0-1.0-0.8-0.8
Delay discounting total patch changes 6 sec0.91.31.41.2-1.2-1.1-1.1
Delay discounting time to switch 0 sec0.30.40.50.7-0.7-0.2-0.7
Delay discounting water rate 0 sec2.64.14.2-2.02.02.11.9
Delay discounting water rate 12 sec0.00.10.10.2-0.20.3-0.3
Delay discounting water rate 18 sec2.63.43.5-1.81.81.81.9
Delay discounting water rate 24 sec0.00.10.2-0.20.20.4-0.0
Delay discounting water rate 6 sec0.60.91.2-1.01.01.10.8
Locomotor activity2.94.65.62.2-2.2-1.9-2.4
Locomotor testing distance2.64.35.72.1-2.1-1.7-2.4
Locomotor testing rearing0.40.60.80.6-0.6-0.8-0.9
Light reinforcement 10.00.00.1-0.20.2-0.20.2
Light reinforcement 22.93.84.6-1.91.91.92.1
Reaction time number correct0.20.30.4-0.50.50.30.6
Reaction time mean minus median2.12.73.21.6-1.6-1.5-1.8
Reaction time mean minus median AUC2.63.34.11.8-1.8-1.6-2.0
Reaction time num false alarms2.02.73.81.9-1.9-0.3-1.8
Reaction time num false alarms AUC1.92.63.81.9-1.9-0.2-1.7
Reaction time trials correct on left0.20.30.4-0.50.50.30.6
Reaction time trials on left0.10.20.3-0.40.40.20.5
Reaction time mean0.30.50.50.7-0.7-0.7-0.6
Reaction time mean AUC0.20.30.40.6-0.6-0.5-0.5
Median of all reaction times0.00.00.0-0.00.0-0.20.2
Reaction time omissions2.43.33.81.7-1.7-1.9-1.8
Reaction time false alarm rate2.02.83.92.0-2.0-0.2-1.8
Reaction time premature initiation rate0.10.10.2-0.40.40.30.4
Reaction time premature initiations0.30.50.6-0.70.70.60.8
Std. dev. reaction times2.02.73.21.7-1.7-1.3-1.8
Reaction time trials completed0.10.20.3-0.40.40.20.5
Reaction time trials AUC0.10.10.3-0.30.30.00.5
Social response proportion0.70.82.3-0.50.51.50.4
Social responses0.30.40.90.6-0.60.4-1.0
Social time0.20.31.0-0.20.21.00.2
Conditioned locomotion1.92.32.7-1.61.61.41.4
Cocaine response after cond. corrected0.00.00.00.0-0.0-0.1-0.1
Cocaine response after cond. not corrected0.10.10.1-0.30.30.10.3
Cocaine response before conditioning1.01.31.9-1.11.10.81.4
Saline control response1.72.22.4-1.51.51.41.5
Condit. Reinf. active minus inactive responses0.30.30.4-0.60.60.40.6
Condit. Reinf. active-inactive response ratio0.00.00.00.0-0.0-0.10.1
Condit. Reinf. active responses0.00.00.1-0.20.20.00.3
Condit. Reinf. inactive responses0.00.00.00.0-0.0-0.20.0
Condit. Reinf. lever presses0.40.50.8-0.60.6-0.90.8
Condit. Reinf. lever reinforcers received0.00.00.1-0.20.2-0.10.3
Pavlov. Cond. lever latency0.50.70.90.9-0.90.2-1.0
Pavlov. Cond. magazine entry latency0.00.00.2-0.00.0-0.4-0.0
Pavlov. Cond. change in total contacts0.10.10.2-0.20.2-0.50.2
Pavlov. Cond. index score0.30.40.6-0.70.7-0.10.8
Pavlov. Cond. latency score0.40.50.6-0.80.80.10.8
Pavlov. Cond. lever contacts0.10.10.2-0.20.2-0.50.2
Pavlov. Cond. magazine entry number0.10.10.2-0.30.30.40.3
Pavlov. Cond. intertrial magazine entries0.60.81.01.0-1.0-0.7-0.9
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.50.5-0.30.5
Pavlov. Cond. response bias0.10.20.2-0.40.4-0.30.4
Conditioned reinforcement - actives4.44.45.4-1.91.92.32.2
Conditioned reinforcement - inactives5.15.86.4-2.52.52.12.5
Conditioned locomotion6.37.510.0-2.52.53.22.8
Intermittent access intake day 1-15 change4.44.46.4-1.61.62.42.5
Intermittent access intake escalation3.13.04.8-1.31.32.02.2
Intermittent access intake escalation 20.60.61.4-0.50.50.71.2
Intermitt. access day 1 inactive lever presses0.10.10.10.3-0.3-0.1-0.4
Intermitt. access day 15 inactive lever presses0.10.10.1-0.30.3-0.10.3
Intermitt. access escalation Index1.11.01.21.1-1.1-0.9-0.9
Intermittent access day 1 total infusions1.51.72.3-1.51.51.01.1
Intermittent access day 15 total infusions2.83.14.5-1.61.61.72.1
Intermittent access terminal intake (last 3 days)2.32.64.3-1.51.51.22.1
Intermittent access total infusions2.42.62.9-1.71.71.51.6
Intermittent access day 1 locomotion2.52.52.9-1.61.61.51.7
Intermittent access day 15 total locomotion0.60.61.2-0.30.31.11.0
Intermittent access total locomotion1.82.13.5-1.21.21.91.3
Intermittent access standard deviation0.20.20.70.0-0.00.50.8
Cocaine induced anxiety1.51.82.4-1.31.31.51.2
Post-drug Anxiety0.10.10.20.2-0.2-0.2-0.4
Baseline Anxiety2.52.63.51.6-1.6-1.9-1.3
Lifetime Intake2.42.72.8-1.61.61.61.7
Incentive Sensitization - Responses1.51.53.4-1.01.00.61.8
Incentive Sensitization - Breakpoint1.11.12.8-0.80.80.41.7
Progressive ratio test 1 active lever presses1.01.01.5-1.21.21.00.4
Progressive ratio test 1 breakpoint1.21.31.8-1.31.31.10.5
Progressive ratio test 1 inactive lever presses1.71.82.3-1.31.31.51.3
Progressive ratio test 2 active lever presses2.12.22.6-1.61.61.21.6
Progressive ratio test 2 breakpoint2.52.83.3-1.81.81.21.7
Progressive ratio test 2 inactive lever presses2.42.74.3-1.51.51.42.1
Total sessions with >9 infusions3.23.54.1-2.02.01.51.8
Short access day 1 total inactive lever presses2.02.22.5-1.61.61.61.3
Short access day 10 total inactive lever presses0.80.81.40.6-0.6-1.1-1.2
Short access day 1 total infusions1.61.71.8-1.31.31.21.3
Short access day 10 total infusions2.32.53.1-1.41.41.71.8
Short access total infusions1.82.02.6-1.61.61.21.3
Short access day 1 locomotion2.93.13.4-1.81.81.71.6
Short access day 10 total locomotion1.21.31.7-1.21.20.91.3
Short access total locomotion3.53.64.0-2.02.01.81.8
Compulsive drug intake0.40.40.60.5-0.5-0.7-0.8
One hour access (0.3 mA shock)4.35.15.5-2.32.32.02.3
One hour access (shock baseline)3.84.45.2-2.12.12.02.3
Number of responses in last shaping day1.81.82.9-1.11.11.71.4
Context. condit. distance diff. score0.40.50.6-0.80.80.70.6
Locomotion velocity, session 10.30.30.50.6-0.6-0.3-0.7
Locomotion distance, session 10.20.20.2-0.50.50.40.4
Locomotion velocity, session 20.30.30.40.6-0.6-0.6-0.5
Locomotion distance, session 20.00.00.00.2-0.2-0.1-0.2
Locomotion velocity, session 30.10.10.20.0-0.00.5-0.1
Locomotion distance, session 30.20.20.9-0.00.01.0-0.1
Stereotopy head waving bouts, day 32.63.13.8-1.91.91.12.0
Stereotopy head waving duration, day 30.50.60.7-0.90.90.10.9
Locomotion velocity, session 70.10.10.2-0.00.00.50.1
Locomotion distance, session 70.30.40.60.7-0.7-0.4-0.8
Stereotopy head waving bouts, day 70.10.10.40.0-0.0-0.7-0.0
Stereotopy head waving duration, day 70.10.10.1-0.40.4-0.20.4
Locomotion velocity, session 80.50.60.9-0.90.90.20.8
Locomotion distance, session 81.21.82.1-1.51.51.21.3
Degree of sensitization distance1.61.62.81.1-1.1-1.7-1.0
Degree of sensitization stereotypy0.91.01.80.9-0.9-1.3-0.8
Condit. Reinf. active minus inactive responses3.33.74.02.0-2.0-1.7-1.9
Condit. Reinf. active-inactive response ratio2.12.22.61.6-1.6-1.1-1.6
Condit. Reinf. active responses0.50.60.80.9-0.9-0.6-0.8
Condit. Reinf. inactive responses1.01.21.3-1.11.11.01.1
Incentive salience index mean1.41.71.91.4-1.4-1.0-1.3
Condit. Reinf. lever presses0.00.00.1-0.00.00.30.0
Time in familiar zone, hab. session 11.31.21.31.1-1.1-0.9-1.1
Time in novel zone, hab. session 10.10.10.30.3-0.3-0.6-0.3
Total zone transitions, hab. session 10.20.30.5-0.40.40.70.4
Total locomotion distance, hab. session 10.40.60.7-0.80.80.40.8
Locomotion velocity, hab. session 11.01.41.7-1.31.31.01.3
Time in familiar zone, hab. session 20.00.00.00.2-0.20.1-0.2
Time in novel zone, hab. session 20.20.20.40.4-0.4-0.6-0.4
Total zone transitions, hab. session 20.10.20.7-0.20.20.80.0
Total locomotion distance, hab. session 20.00.00.1-0.00.00.3-0.1
Locomotion velocity, hab. session 20.00.00.1-0.10.10.3-0.1
Novel to familiar place preference ratio0.00.00.0-0.10.10.10.1
Novelty place preference0.10.10.10.2-0.2-0.3-0.3
Time in novel zone, NPP test0.10.10.10.2-0.2-0.2-0.3
Total zone transitions, NPP test0.20.40.8-0.50.50.90.4
Total locomotion distance, NPP test0.81.11.1-1.11.11.11.0
Locomotion velocity, NPP test0.91.31.3-1.11.11.11.1
Pavlov. Cond. lever latency0.00.00.10.1-0.1-0.2-0.1
Pavlov. Cond. magazine entry latency0.20.30.30.5-0.5-0.5-0.6
Pavlov. Cond. change in total contacts0.00.00.0-0.10.10.10.2
Pavlov. Cond. index score0.00.00.10.1-0.1-0.2-0.1
Pavlov. Cond. latency score0.00.00.00.0-0.0-0.1-0.1
Pavlov. Cond. lever contacts0.00.00.0-0.10.10.00.1
Pavlov. Cond. magazine entry number0.10.10.2-0.10.10.50.2
Pavlov. Cond. intertrial magazine entries1.41.61.8-1.31.31.11.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.30.30.20.3
Pavlov. Cond. response bias0.20.30.4-0.60.60.20.5
Bone: apparent density3.55.76.2-2.42.42.52.2
Bone surface1.22.02.2-1.51.51.41.4
Bone volume2.64.34.5-2.12.12.12.0
Bone: connectivity density1.82.83.3-1.81.81.41.6
Bone: cortical apparent density0.10.10.2-0.30.3-0.40.2
Bone: cortical area0.10.20.20.5-0.50.4-0.4
Bone: cortical porosity2.12.22.3-1.51.51.41.5
Bone: cortical porosity1.71.81.9-1.41.41.31.3
Bone: cortical thickness0.20.40.50.7-0.70.2-0.6
Bone: cortical thickness0.70.81.0-0.80.81.00.9
Bone: cortical tissue density0.10.10.2-0.20.2-0.50.1
Bone: elastic displacement1.21.41.7-1.31.30.91.2
Bone: elastic work1.21.51.9-1.21.21.41.2
Bone: endosteal estimation0.20.40.5-0.70.70.30.7
Bone: endosteal perimeter0.00.00.00.1-0.1-0.1-0.1
Bone: final force0.10.20.30.5-0.5-0.2-0.4
Bone: final moment0.10.10.20.4-0.4-0.2-0.2
Bone: marrow area0.20.40.5-0.70.70.30.7
Bone: maximum diameter0.10.10.3-0.10.10.50.2
Bone: maximum force0.10.10.10.4-0.4-0.2-0.2
Bone: maximum moment0.00.00.10.2-0.2-0.2-0.1
Bone: minimum diameter0.81.61.91.4-1.4-0.9-1.2
Bone: periosteal estimation0.10.20.5-0.40.40.70.5
Bone: periosteal perimeter0.00.10.10.2-0.20.4-0.2
Bone: post-yield work0.71.01.2-1.11.10.61.1
Bone: stiffness0.10.20.20.5-0.5-0.4-0.3
Bone: tissue strength0.60.60.90.7-0.7-1.0-0.6
Bone: trabecular number3.04.75.3-2.32.31.92.1
Bone: trabecular spacing0.81.11.21.1-1.1-1.1-0.8
Bone: trabecular thickness0.20.20.4-0.50.50.70.3
Bone: trabecular tissue density0.10.10.5-0.10.10.70.2
Breakpoint value in progressive ratio session1.92.12.8-1.71.71.11.3
Distance traveled before self-admin0.40.40.70.7-0.7-0.90.1
Distance traveled after self-admin0.20.31.1-0.00.0-1.0-0.2
Delta time in closed arm before/after self-admin0.10.10.20.1-0.1-0.3-0.5
Delta time in open arm before/after self-admin0.40.40.40.6-0.6-0.6-0.6
Diff in mean of infusions in LGA sessions0.20.30.70.1-0.1-0.5-0.9
Extinction: sum of active levers before priming0.20.20.4-0.70.7-0.3-0.0
Active lever presses in extinction session 60.10.10.40.0-0.0-0.4-0.6
Delta distance traveled before/after self-admin0.60.71.50.3-0.3-1.0-1.2
Delta ambulatory time before/after self-admin0.10.10.2-0.50.50.3-0.1
Time in closed arm before self-admin0.10.10.20.4-0.40.00.0
Time in closed arm after self-admin0.91.01.40.8-0.8-1.1-1.2
Time in open arm before self-admin0.10.10.40.2-0.2-0.60.1
Time in open arm after self-admin0.10.10.3-0.10.10.10.5
Sum of active levers in priming session hrs 5-60.10.10.1-0.40.4-0.10.1
Time to tail flick, vehicle, before self-admin2.32.34.21.1-1.1-2.0-1.5
Time to tail flick, vehicle, after self-admin6.46.89.92.3-2.3-2.6-3.1
Time to tail flick, test, before self-admin2.42.43.7-1.91.90.81.2
Time to tail flick, test, after self-admin0.90.91.3-1.11.10.41.0
Delta time to tail flick, vehicle, before/after SA0.70.61.20.8-0.8-0.1-1.1
Delta time to tail flick, test, before/after SA1.51.32.2-0.70.71.41.5
Ambulatory time before self-admin0.70.82.00.7-0.7-1.4-0.2
Ambulatory time after self-admin0.40.51.60.3-0.3-1.3-0.2
Total heroin consumption2.02.44.5-1.31.31.22.1
Area under the delay curve0.00.00.00.1-0.10.20.1
Delay disc. indifference point, 0s delay0.40.40.90.7-0.7-0.9-0.2
Delay disc. indifference point, 16s delay0.10.10.3-0.10.10.50.1
Delay disc. indifference point, 2s delay0.10.10.30.0-0.0-0.50.3
Delay disc. indifference point, 24s delay3.23.13.8-1.91.91.91.3
Delay disc. indifference point, 4s delay0.10.10.20.2-0.20.40.3
Delay disc. indifference point, 8s delay0.00.00.0-0.10.10.20.1
Delay discount exponential model param0.10.10.30.2-0.2-0.6-0.2
Delay discount hyperbolic model param0.00.00.10.1-0.1-0.3-0.3
Fecal boli incidents, locomotor time 13.94.24.7-2.02.02.02.2
Change in fecal boli incidents, locomotor task2.01.92.81.7-1.7-0.5-1.3
Time >=10cm from walls, locomotor time 10.20.30.4-0.50.5-0.10.6
Bouts of movement, locomotor time 10.30.30.4-0.60.6-0.40.6
Total resting periods, locomotor time 10.50.50.8-0.90.90.10.7
Rest time, locomotor task time 10.30.40.5-0.70.70.40.6
Distance moved, locomotor task time 10.91.01.50.8-0.8-1.2-1.1
Vertical activity count, locomotor time 10.30.30.50.6-0.6-0.7-0.2
Time >=10cm from walls, locomotor time 21.31.42.1-1.21.20.51.5
Bouts of movement, locomotor time 20.00.00.20.1-0.10.40.1
Total resting periods, locomotor time 20.10.10.3-0.10.10.50.2
Rest time, locomotor task time 20.10.10.3-0.20.20.50.2
Distance moved, locomotor task time 20.20.31.1-0.10.1-1.0-0.0
Vertical activity count, locomotor time 20.30.30.8-0.40.4-0.90.4
Weight adjusted by age0.60.72.00.4-0.4-0.6-1.4
Seeking ratio, delayed vs. immediate footshock1.21.42.41.2-1.2-1.6-0.6
Locomotion in novel chamber1.72.12.71.2-1.2-1.7-1.6
Locomotion in novel chamber post-restriction0.50.51.90.1-0.1-1.4-0.5
Progressive ratio0.20.20.40.6-0.60.1-0.1
Food seeking constrained by brief footshock6.68.08.8-2.92.92.63.0
Seeking ratio, punishment vs. effort1.82.22.7-1.71.71.11.5
Run reversals in cocaine runway, females0.70.71.2-0.80.80.51.1
Run reversals in cocaine runway, males0.60.60.9-0.90.90.30.7
Latency to leave start box in cocaine runway1.61.86.3-0.50.52.50.4
Latency to leave start box in cocaine runway, F0.70.72.7-0.30.31.6-0.3
Latency to leave start box in cocaine runway, M2.32.25.6-1.01.02.41.2
Cd content in liver0.00.10.1-0.30.3-0.20.1
Co content in liver1.82.12.6-1.61.61.01.6
Cu content in liver0.50.70.80.8-0.8-0.7-0.9
Fe content in liver0.81.01.5-1.01.01.20.7
K content in liver2.02.02.51.6-1.6-0.8-1.6
Mg content in liver0.80.80.91.0-1.0-0.6-0.9
Mn content in liver0.00.00.1-0.10.10.00.2
Na content in liver2.32.52.6-1.61.61.61.6
Rb content in liver0.50.70.90.8-0.8-0.7-0.9
Se content in liver0.30.30.40.6-0.6-0.2-0.6
Sr content in liver0.10.00.1-0.30.30.10.2
Zn content in liver5.76.36.82.6-2.6-2.2-2.6