Hub : Genes

Card14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr10:104589940:104590111	0.03	0.02	9.0e-03	0.01	0.02	0.01	0.01	7.8e-02	3.3e-03	2.1e-02	1.9e-02
2	Brain	mRNA stability	ENSRNOG00000047367	0.05	0.03	5.5e-05	0.04	0.05	0.04	0.04	2.8e-04	2.4e-05	1.3e-04	5.5e-05
3	Eye	intron excision ratio	chr10:104582228:104584014	0.33	0.17	4.4e-03	0	0.05	-0.01	0.03	3.0e-01	5.6e-02	4.9e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	0.1	0.2	0.5	0.3	0.7	-0.3
BMI without tail	0.9	1.9	3.1	1.0	1.8	-1.2
Body weight	4.3	18.3	20.7	4.0	4.5	-4.2
Epididymis fat weight	0.7	1.7	2.2	1.1	1.5	-1.2
Glucose	1.8	2.8	3.7	-1.4	-1.9	1.6
Heart weight	0.1	0.2	0.2	0.4	0.4	-0.5
Left kidney weight	1.4	4.0	4.1	2.0	2.0	-2.0
Right kidney weight	0.9	2.7	2.8	1.6	1.7	-1.6
Tail length	5.2	15.7	17.3	3.8	4.2	-4.0
Length with tail	5.4	19.9	20.3	4.4	4.5	-4.5
Length without tail	1.5	3.3	3.7	1.9	1.7	-1.9
Liver weight, left	0.3	0.5	0.6	0.7	0.6	-0.7
Liver weight, right	5.0	8.2	8.6	2.9	2.8	-2.9
Parametrial fat weight	1.4	2.7	2.9	1.6	1.6	-1.7
Retroperitoneal fat weight	4.2	14.0	16.4	3.5	4.0	-3.7
Intraocular pressure	0.0	0.0	0.0	-0.2	-0.1	0.2
Extensor digitorum longus weight	0.3	1.4	1.8	-1.3	-1.0	1.2
Soleus weight	1.0	3.0	3.2	1.8	1.6	-1.8
Tibialis anterior weight	0.1	0.3	0.4	-0.6	-0.6	0.5
Tibia length	16.9	47.7	49.6	6.8	7.0	-6.9
Number of licking bursts	0.2	0.3	0.3	0.5	0.6	-0.5
Food consumed during 24 hour testing period	0.4	0.5	0.8	0.6	0.9	-0.6
Times rat made contact with spout	1.0	1.1	1.3	1.1	1.0	-1.1
Mean time between licks in bursts	0.9	1.2	1.3	-1.1	-1.1	1.1
Mean num. licks in bursts	0.0	0.0	0.0	0.1	-0.1	-0.1
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.2	0.2	0.1
Water consumed over 24 hours	0.0	0.1	0.1	0.3	0.1	-0.3
Indifference point 0 sec	0.0	0.1	0.1	-0.2	-0.2	0.2
Indifference point AUC	0.0	0.0	0.0	-0.2	-0.1	0.1
Indifference point function ln k	1.6	2.2	2.3	-1.5	-1.5	1.5
Indifference point function log k	1.6	2.2	2.3	-1.5	-1.5	1.5
Delay discounting total patch changes 0 sec	0.1	0.2	0.2	-0.5	-0.4	0.4
Delay discounting total patch changes 12 sec	0.1	0.1	0.1	-0.3	-0.3	0.3
Delay discounting total patch changes 18 sec	0.7	0.9	1.1	-1.1	-0.7	1.0
Delay discounting total patch changes 24 sec	0.6	0.8	1.0	0.8	1.0	-0.9
Delay discounting total patch changes 6 sec	0.1	0.2	0.3	0.5	0.3	-0.5
Delay discounting time to switch 0 sec	0.2	0.3	0.3	-0.5	-0.6	0.5
Delay discounting water rate 0 sec	1.2	1.9	2.7	1.2	1.6	-1.3
Delay discounting water rate 12 sec	0.4	0.6	0.8	-0.9	-0.5	0.8
Delay discounting water rate 18 sec	0.1	0.1	0.2	0.1	0.4	-0.2
Delay discounting water rate 24 sec	0.1	0.1	0.3	-0.1	0.6	-0.0
Delay discounting water rate 6 sec	0.0	0.0	0.0	-0.2	0.1	0.1
Locomotor activity	0.4	0.7	0.7	-0.8	-0.8	0.8
Locomotor testing distance	0.3	0.6	0.7	-0.8	-0.7	0.8
Locomotor testing rearing	0.2	0.3	0.4	-0.6	-0.3	0.6
Light reinforcement 1	0.2	0.4	0.6	0.6	0.7	-0.6
Light reinforcement 2	2.0	2.6	2.7	1.6	1.7	-1.6
Reaction time number correct	1.0	1.4	2.1	-1.5	-0.8	1.2
Reaction time mean minus median	0.0	0.0	0.1	0.3	0.0	-0.2
Reaction time mean minus median AUC	0.7	0.9	1.0	1.0	0.9	-1.0
Reaction time num false alarms	0.3	0.4	0.4	-0.6	-0.7	0.7
Reaction time num false alarms AUC	0.6	0.9	0.9	-0.9	-0.9	0.9
Reaction time trials correct on left	1.0	1.4	2.1	-1.5	-0.8	1.2
Reaction time trials on left	1.0	1.4	2.1	-1.4	-0.7	1.2
Reaction time mean	0.0	0.0	0.1	0.1	0.3	-0.2
Reaction time mean AUC	0.0	0.0	0.0	-0.0	0.2	-0.0
Median of all reaction times	0.0	0.0	0.1	-0.0	0.3	-0.0
Reaction time omissions	0.4	0.5	0.7	0.6	0.8	-0.7
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	-0.5	0.3
Reaction time premature initiation rate	2.3	3.1	3.5	-1.7	-1.9	1.8
Reaction time premature initiations	3.5	4.9	5.4	-2.3	-2.1	2.3
Std. dev. reaction times	0.3	0.4	0.5	-0.7	-0.6	0.7
Reaction time trials completed	1.0	1.4	2.1	-1.4	-0.7	1.2
Reaction time trials AUC	1.0	1.4	2.1	-1.4	-0.7	1.2
Social response proportion	0.2	0.2	0.2	-0.5	-0.3	0.5
Social responses	0.0	0.0	0.1	0.1	0.3	-0.1
Social time	0.2	0.3	0.3	-0.6	-0.5	0.6
Conditioned locomotion	1.8	2.1	2.7	1.3	1.6	-1.4
Cocaine response after cond. corrected	0.1	0.1	0.1	-0.3	-0.2	0.2
Cocaine response after cond. not corrected	0.3	0.4	0.4	-0.6	-0.6	0.6
Cocaine response before conditioning	0.4	0.5	0.6	-0.7	-0.7	0.7
Saline control response	2.9	3.8	4.0	1.9	2.0	-2.0
Condit. Reinf. active minus inactive responses	1.6	2.0	2.5	1.4	1.6	-1.3
Condit. Reinf. active-inactive response ratio	3.5	3.7	3.7	1.9	1.9	-1.9
Condit. Reinf. active responses	0.1	0.1	0.3	0.2	0.5	-0.2
Condit. Reinf. inactive responses	1.3	1.6	1.7	-1.3	-1.1	1.3
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	-0.2	0.5
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	-0.2	0.2	0.2
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.3	-0.0	-0.2
Pavlov. Cond. magazine entry latency	3.5	4.0	4.6	-2.2	-1.8	2.1
Pavlov. Cond. change in total contacts	1.3	1.8	2.2	-1.5	-1.1	1.4
Pavlov. Cond. index score	1.1	1.4	1.8	-1.3	-0.9	1.2
Pavlov. Cond. latency score	0.9	1.1	1.4	-1.2	-0.8	1.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	0.3	0.0
Pavlov. Cond. magazine entry number	3.2	3.9	4.5	2.1	1.7	-2.0
Pavlov. Cond. intertrial magazine entries	2.1	2.7	2.9	1.6	1.7	-1.6
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.4	-1.5	-1.1	1.4
Pavlov. Cond. response bias	0.5	0.6	0.9	-0.9	-0.5	0.8
Conditioned reinforcement - actives	0.0	0.0	0.0	0.2	0.1	-0.2
Conditioned reinforcement - inactives	1.5	1.7	1.8	1.3	1.3	-1.3
Conditioned locomotion	0.3	0.4	0.4	0.7	0.5	-0.7
Intermittent access intake day 1-15 change	0.2	0.2	0.3	0.4	0.5	-0.5
Intermittent access intake escalation	0.3	0.3	0.3	0.5	0.6	-0.5
Intermittent access intake escalation 2	1.0	1.0	1.0	1.0	1.0	-1.0
Intermitt. access day 1 inactive lever presses	2.2	2.4	2.7	1.5	1.6	-1.5
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.9	0.7	0.9	-0.8
Intermitt. access escalation Index	1.4	1.2	1.4	1.1	1.2	-1.1
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	0.2	-0.2
Intermittent access day 15 total infusions	0.4	0.5	0.5	0.7	0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.1	1.0	1.0	-1.0
Intermittent access total infusions	0.3	0.3	0.3	0.5	0.5	-0.6
Intermittent access day 1 locomotion	0.2	0.2	0.3	0.5	0.4	-0.5
Intermittent access day 15 total locomotion	0.6	0.6	0.7	0.8	0.7	-0.8
Intermittent access total locomotion	0.4	0.4	0.5	0.7	0.6	-0.7
Intermittent access standard deviation	0.1	0.1	0.2	0.3	0.4	-0.3
Cocaine induced anxiety	6.1	7.0	7.6	2.6	2.8	-2.6
Post-drug Anxiety	0.9	1.0	1.5	0.8	1.2	-0.9
Baseline Anxiety	6.5	6.9	7.1	-2.6	-2.6	2.7
Lifetime Intake	0.1	0.1	0.1	0.3	0.3	-0.3
Incentive Sensitization - Responses	0.1	0.1	0.1	0.3	0.3	-0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	0.4	0.3	-0.4
Progressive ratio test 1 active lever presses	0.3	0.3	0.3	0.6	0.5	-0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.3	0.5	0.5	-0.6
Progressive ratio test 1 inactive lever presses	2.7	2.8	3.3	1.6	1.8	-1.7
Progressive ratio test 2 active lever presses	0.3	0.3	0.3	0.6	0.5	-0.6
Progressive ratio test 2 breakpoint	0.3	0.3	0.3	0.6	0.6	-0.6
Progressive ratio test 2 inactive lever presses	0.7	0.8	0.8	0.9	0.9	-0.9
Total sessions with >9 infusions	0.2	0.2	0.2	-0.4	-0.5	0.4
Short access day 1 total inactive lever presses	0.4	0.4	0.4	0.7	0.6	-0.7
Short access day 10 total inactive lever presses	4.0	4.4	4.9	2.0	2.2	-2.1
Short access day 1 total infusions	0.7	0.8	0.8	-0.8	-0.9	0.9
Short access day 10 total infusions	0.5	0.5	0.6	0.7	0.7	-0.8
Short access total infusions	0.0	0.0	0.1	-0.2	-0.2	0.2
Short access day 1 locomotion	0.0	0.0	0.0	0.1	-0.1	-0.1
Short access day 10 total locomotion	0.0	0.0	0.1	0.2	0.0	-0.2
Short access total locomotion	0.0	0.0	0.1	-0.0	-0.3	0.1
Compulsive drug intake	0.1	0.1	0.2	0.2	0.4	-0.3
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.5	0.6	-0.5
One hour access (shock baseline)	0.2	0.3	0.3	0.6	0.4	-0.6
Number of responses in last shaping day	2.6	2.7	2.8	1.7	1.6	-1.7
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	0.2	0.2
Locomotion velocity, session 1	0.5	0.5	0.8	-0.6	-0.9	0.7
Locomotion distance, session 1	2.8	3.6	3.7	-1.9	-1.9	1.9
Locomotion velocity, session 2	3.6	4.3	5.2	-1.9	-2.3	2.0
Locomotion distance, session 2	1.3	1.8	1.9	-1.3	-1.4	1.4
Locomotion velocity, session 3	0.5	0.5	0.7	-0.6	-0.8	0.7
Locomotion distance, session 3	3.0	3.3	3.5	-1.8	-1.9	1.8
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.1	-0.2	0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.1	-0.0	0.1
Locomotion velocity, session 7	0.7	0.7	0.8	-0.9	-0.8	0.9
Locomotion distance, session 7	5.5	7.1	7.7	-2.8	-2.5	2.7
Stereotopy head waving bouts, day 7	0.5	0.5	0.8	0.6	0.9	-0.7
Stereotopy head waving duration, day 7	1.7	2.1	2.4	1.4	1.5	-1.4
Locomotion velocity, session 8	0.2	0.3	0.4	-0.6	-0.1	0.6
Locomotion distance, session 8	0.8	1.2	1.7	-1.3	-0.8	1.2
Degree of sensitization distance	0.0	0.0	0.1	-0.3	0.0	0.2
Degree of sensitization stereotypy	0.6	0.6	0.9	0.7	1.0	-0.7
Condit. Reinf. active minus inactive responses	1.1	1.3	1.4	1.1	1.2	-1.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.5	0.7	-0.5
Condit. Reinf. active responses	2.2	2.7	2.7	1.6	1.6	-1.6
Condit. Reinf. inactive responses	0.5	0.6	0.6	0.8	0.7	-0.8
Incentive salience index mean	1.2	1.5	1.5	1.2	1.2	-1.2
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	0.0	-0.0
Time in familiar zone, hab. session 1	0.4	0.4	0.4	-0.6	-0.6	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.4	0.6	-0.4
Total zone transitions, hab. session 1	0.9	1.2	1.4	-1.2	-1.0	1.1
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.4	-0.1	0.3
Locomotion velocity, hab. session 1	0.0	0.1	0.1	-0.3	-0.1	0.3
Time in familiar zone, hab. session 2	0.6	0.6	0.7	-0.9	-0.7	0.8
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	0.1	-0.1
Total zone transitions, hab. session 2	1.7	2.2	2.4	-1.5	-1.4	1.5
Total locomotion distance, hab. session 2	0.2	0.3	0.3	-0.6	-0.4	0.6
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.3	-0.2	0.3
Novel to familiar place preference ratio	0.4	0.4	0.5	0.7	0.6	-0.6
Novelty place preference	0.4	0.5	0.5	0.7	0.6	-0.7
Time in novel zone, NPP test	0.2	0.2	0.2	0.5	0.4	-0.5
Total zone transitions, NPP test	1.4	2.0	2.2	-1.5	-1.3	1.5
Total locomotion distance, NPP test	0.9	1.2	1.4	-1.2	-1.0	1.2
Locomotion velocity, NPP test	0.5	0.7	0.8	-0.9	-0.7	0.9
Pavlov. Cond. lever latency	2.8	3.6	4.4	-2.1	-1.5	2.0
Pavlov. Cond. magazine entry latency	4.4	5.7	6.0	2.4	2.3	-2.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.5	0.2	-0.4
Pavlov. Cond. index score	5.8	7.4	7.8	2.8	2.6	-2.8
Pavlov. Cond. latency score	5.4	6.9	7.6	2.7	2.4	-2.7
Pavlov. Cond. lever contacts	1.7	2.1	2.5	1.6	1.2	-1.5
Pavlov. Cond. magazine entry number	3.9	4.9	5.2	-2.3	-2.1	2.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.4	-0.7	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	5.5	6.9	7.3	2.7	2.5	-2.7
Pavlov. Cond. response bias	3.7	4.5	4.9	2.2	1.9	-2.2
Bone: apparent density	0.1	0.1	0.1	-0.3	-0.4	0.3
Bone surface	0.2	0.4	0.5	0.7	0.6	-0.7
Bone volume	0.0	0.0	0.0	0.2	0.2	-0.2
Bone: connectivity density	0.2	0.3	0.4	-0.6	-0.6	0.6
Bone: cortical apparent density	3.3	4.3	4.9	-2.0	-2.2	2.1
Bone: cortical area	7.7	11.7	11.7	3.4	3.4	-3.4
Bone: cortical porosity	1.6	1.8	2.0	1.4	1.1	-1.4
Bone: cortical porosity	1.9	2.0	2.2	1.5	1.3	-1.5
Bone: cortical thickness	6.0	10.0	10.6	3.3	3.0	-3.2
Bone: cortical thickness	2.1	2.4	2.5	1.6	1.6	-1.5
Bone: cortical tissue density	3.8	5.0	5.6	-2.1	-2.4	2.2
Bone: elastic displacement	0.8	0.9	1.0	1.0	0.9	-0.9
Bone: elastic work	6.5	8.5	9.0	3.0	2.8	-3.0
Bone: endosteal estimation	0.1	0.1	0.2	-0.5	-0.2	0.4
Bone: endosteal perimeter	1.3	2.6	2.6	1.6	1.6	-1.6
Bone: final force	5.9	9.7	10.3	3.1	3.2	-3.1
Bone: final moment	6.5	10.8	11.3	3.2	3.4	-3.3
Bone: marrow area	0.1	0.1	0.2	-0.5	-0.2	0.4
Bone: maximum diameter	3.6	6.7	7.0	2.5	2.6	-2.6
Bone: maximum force	5.2	9.1	9.4	3.0	3.1	-3.0
Bone: maximum moment	5.7	9.9	10.2	3.1	3.2	-3.2
Bone: minimum diameter	3.9	7.2	7.5	2.6	2.7	-2.7
Bone: periosteal estimation	2.0	4.1	4.6	1.9	2.1	-2.0
Bone: periosteal perimeter	6.0	10.0	10.4	3.2	3.0	-3.2
Bone: post-yield work	0.2	0.2	0.3	-0.5	-0.5	0.5
Bone: stiffness	1.1	1.7	1.8	1.3	1.3	-1.3
Bone: tissue strength	0.3	0.3	0.4	0.5	0.6	-0.6
Bone: trabecular number	0.1	0.1	0.1	-0.2	-0.4	0.3
Bone: trabecular spacing	0.1	0.1	0.4	-0.2	0.6	0.0
Bone: trabecular thickness	0.1	0.2	0.3	0.6	0.0	-0.5
Bone: trabecular tissue density	0.1	0.2	0.2	-0.4	-0.4	0.4
Breakpoint value in progressive ratio session	0.1	0.1	0.1	0.2	0.3	-0.3
Distance traveled before self-admin	1.8	1.9	2.1	1.3	1.5	-1.3
Distance traveled after self-admin	0.1	0.1	0.1	-0.4	-0.2	0.3
Delta time in closed arm before/after self-admin	0.7	0.7	0.7	0.9	0.8	-0.8
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.2	-0.0	0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	0.1	0.0
Extinction: sum of active levers before priming	1.6	1.6	1.6	-1.2	-1.3	1.3
Active lever presses in extinction session 6	0.1	0.1	0.2	0.3	0.4	-0.3
Delta distance traveled before/after self-admin	1.4	1.5	1.6	-1.3	-1.1	1.2
Delta ambulatory time before/after self-admin	2.4	2.7	2.8	-1.7	-1.6	1.6
Time in closed arm before self-admin	0.4	0.4	0.5	-0.6	-0.7	0.6
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.1
Time in open arm before self-admin	0.2	0.2	0.2	0.4	0.3	-0.4
Time in open arm after self-admin	0.1	0.1	0.1	-0.3	-0.2	0.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.1	0.0
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.3	0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.1	-0.8	-1.1	0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	0.1	-0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.3	0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.5	-0.4	0.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.2	-0.1	0.2
Ambulatory time before self-admin	3.4	3.6	4.1	1.8	2.0	-1.8
Ambulatory time after self-admin	0.0	0.0	0.1	0.0	0.3	-0.1
Total heroin consumption	0.3	0.4	0.5	0.6	0.7	-0.6
Area under the delay curve	0.1	0.1	0.1	-0.3	-0.2	0.4
Delay disc. indifference point, 0s delay	0.5	0.5	0.7	0.7	0.8	-0.7
Delay disc. indifference point, 16s delay	1.4	1.4	1.7	-1.3	-1.0	1.3
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	0.5	0.6	-0.5
Delay disc. indifference point, 24s delay	2.3	2.3	2.5	-1.4	-1.6	1.5
Delay disc. indifference point, 4s delay	0.2	0.3	0.5	0.4	0.7	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.3	0.3	-0.2
Delay discount exponential model param	0.2	0.2	0.2	0.4	0.3	-0.5
Delay discount hyperbolic model param	0.1	0.1	0.2	0.4	0.2	-0.4
Fecal boli incidents, locomotor time 1	1.3	1.4	1.6	-1.1	-1.3	1.1
Change in fecal boli incidents, locomotor task	2.6	2.5	2.8	-1.5	-1.7	1.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	-0.6	-0.3	0.5
Bouts of movement, locomotor time 1	2.3	2.5	2.8	-1.5	-1.7	1.6
Total resting periods, locomotor time 1	2.7	3.1	3.6	-1.6	-1.9	1.7
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.2	-0.5	0.2
Distance moved, locomotor task time 1	0.7	0.8	1.1	0.8	1.0	-0.9
Vertical activity count, locomotor time 1	0.2	0.2	0.3	0.3	0.6	-0.4
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.2	0.2	-0.2
Bouts of movement, locomotor time 2	1.3	1.4	1.4	-1.2	-1.2	1.2
Total resting periods, locomotor time 2	0.9	0.9	1.0	-1.0	-1.0	1.0
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.2	-0.3	0.2
Distance moved, locomotor task time 2	0.8	0.9	1.0	0.9	1.0	-0.9
Vertical activity count, locomotor time 2	0.2	0.2	0.3	0.3	0.5	-0.3
Weight adjusted by age	3.4	3.8	3.9	1.9	2.0	-2.0
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	2.0	1.4	1.3	-1.4
Locomotion in novel chamber	0.0	0.0	0.0	-0.2	-0.0	0.1
Locomotion in novel chamber post-restriction	0.5	0.6	0.7	0.8	0.6	-0.8
Progressive ratio	0.7	0.8	1.0	-0.9	-1.0	0.9
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.2	-0.2	0.2
Seeking ratio, punishment vs. effort	0.3	0.3	0.4	0.5	0.7	-0.5
Run reversals in cocaine runway, females	1.4	1.4	1.6	-1.3	-1.0	1.2
Run reversals in cocaine runway, males	0.6	0.6	0.8	0.9	0.6	-0.9
Latency to leave start box in cocaine runway	1.3	1.4	1.6	-1.1	-1.3	1.1
Latency to leave start box in cocaine runway, F	0.7	0.7	0.8	-0.9	-0.8	0.9
Latency to leave start box in cocaine runway, M	0.6	0.6	0.9	-0.6	-0.9	0.7
Cd content in liver	2.2	2.4	2.7	-1.6	-1.4	1.6
Co content in liver	0.5	0.5	0.6	-0.8	-0.7	0.7
Cu content in liver	0.2	0.3	0.4	0.6	0.4	-0.6
Fe content in liver	0.9	1.1	1.2	-1.1	-1.0	1.0
K content in liver	1.5	1.5	1.6	1.2	1.2	-1.2
Mg content in liver	0.2	0.2	0.2	-0.5	-0.4	0.4
Mn content in liver	0.7	0.8	0.9	0.9	0.9	-0.9
Na content in liver	0.2	0.2	0.3	0.5	0.4	-0.5
Rb content in liver	0.1	0.1	0.2	0.2	0.4	-0.2
Se content in liver	0.1	0.1	0.2	0.2	0.4	-0.2
Sr content in liver	0.1	0.0	0.1	0.3	-0.1	-0.2
Zn content in liver	0.3	0.3	0.4	0.7	0.3	-0.6