Hub : Genes

Ccer2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000046971	0.18	0.11	5.7e-09	0.14	0.14	0.13	0.07	4.3e-08	5.9e-08	1.4e-07	1.2e-04
2	Brain	gene expression	ENSRNOG00000046971	0.05	0.04	1.6e-04	0.03	0.03	0.02	0.02	9.9e-04	1.9e-03	2.2e-03	3.6e-03
3	Liver	gene expression	ENSRNOG00000046971	0.04	0.03	8.2e-03	0.01	0	0	0	5.2e-02	1.4e-01	9.8e-02	1.7e-01
4	OFC	gene expression	ENSRNOG00000046971	0.15	0.1	2.1e-03	0.01	0.08	0.04	0.03	2.1e-01	6.6e-03	4.6e-02	6.0e-02
5	PL	gene expression	ENSRNOG00000046971	0.15	0.09	8.5e-10	0.13	0.14	0.13	0.13	3.9e-10	2.1e-10	4.2e-10	3.5e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.1	0.4	0.9	-0.8	-0.6	0.5	-0.9	-0.2
BMI without tail	0.1	0.2	0.6	0.3	0.4	-0.5	-0.0	0.8
Body weight	2.4	10.3	11.6	3.3	3.4	-3.2	3.4	2.7
Epididymis fat weight	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.3	-0.0
Glucose	0.6	1.0	2.1	-0.8	-0.8	0.8	0.9	-1.4
Heart weight	0.7	1.1	1.4	1.2	1.1	-0.9	1.0	0.9
Left kidney weight	2.7	7.9	8.9	3.0	3.0	-2.7	3.0	2.3
Right kidney weight	3.7	10.6	12.4	3.5	3.4	-3.3	3.0	3.0
Tail length	4.4	13.2	14.7	3.8	3.8	-3.7	3.5	3.3
Length with tail	6.9	25.2	28.4	5.3	5.3	-5.0	5.2	4.1
Length without tail	3.6	7.8	9.9	2.9	3.0	-2.8	3.2	2.0
Liver weight, left	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.3	-0.1
Liver weight, right	0.0	0.1	0.3	0.1	0.2	-0.2	0.5	-0.1
Parametrial fat weight	0.5	0.9	1.6	-0.9	-1.0	1.1	-0.1	-1.2
Retroperitoneal fat weight	0.9	2.9	4.1	-1.7	-1.8	2.0	-1.0	-1.8
Intraocular pressure	0.1	0.2	0.4	-0.5	-0.4	0.4	0.3	-0.6
Extensor digitorum longus weight	0.2	0.7	0.8	-0.9	-0.9	0.9	-0.6	-0.9
Soleus weight	1.0	3.0	6.1	-1.7	-1.7	1.6	-2.5	-0.8
Tibialis anterior weight	0.1	0.3	1.2	0.0	-0.0	0.0	-1.1	0.6
Tibia length	1.9	5.5	6.9	2.4	2.4	-2.4	2.6	1.8
Number of licking bursts	1.7	2.0	4.0	-1.5	-1.5	1.4	-0.1	-2.0
Food consumed during 24 hour testing period	0.5	0.7	2.0	0.6	0.6	-0.7	1.4	0.0
Times rat made contact with spout	0.4	0.5	1.4	-0.6	-0.6	0.6	-1.2	-0.1
Mean time between licks in bursts	0.2	0.3	0.3	0.6	0.6	-0.5	0.6	0.3
Mean num. licks in bursts	0.9	1.1	2.8	0.9	0.9	-0.8	-0.7	1.7
Std. dev. time between licks in bursts	0.5	0.6	1.1	0.8	0.8	-0.8	0.1	1.0
Water consumed over 24 hours	0.9	1.1	1.8	1.0	1.0	-1.1	1.3	0.7
Indifference point 0 sec	0.3	0.4	0.5	0.7	0.6	-0.7	0.7	0.5
Indifference point AUC	0.6	0.7	2.3	-0.5	-0.6	0.8	-1.5	0.0
Indifference point function ln k	0.7	1.0	3.2	0.8	0.7	-0.8	1.8	-0.0
Indifference point function log k	0.7	1.0	3.2	0.8	0.7	-0.8	1.8	-0.0
Delay discounting total patch changes 0 sec	0.3	0.6	0.7	0.8	0.7	-0.8	0.8	0.5
Delay discounting total patch changes 12 sec	0.3	0.4	0.7	0.7	0.7	-0.5	-0.0	0.8
Delay discounting total patch changes 18 sec	0.6	0.8	3.4	-0.2	-0.3	0.5	-1.9	0.6
Delay discounting total patch changes 24 sec	0.5	0.6	0.9	0.9	0.8	-0.6	0.4	0.9
Delay discounting total patch changes 6 sec	0.1	0.2	0.5	0.4	0.3	-0.3	-0.5	0.7
Delay discounting time to switch 0 sec	1.2	1.8	2.1	-1.5	-1.4	1.4	-1.3	-1.1
Delay discounting water rate 0 sec	0.5	0.9	2.0	-0.7	-0.7	0.8	0.8	-1.4
Delay discounting water rate 12 sec	1.2	1.8	4.7	1.1	1.1	-1.2	2.2	0.3
Delay discounting water rate 18 sec	0.8	1.0	2.4	-0.9	-0.9	0.8	0.5	-1.6
Delay discounting water rate 24 sec	0.7	1.0	2.5	0.7	0.8	-1.0	1.6	0.2
Delay discounting water rate 6 sec	0.4	0.6	2.6	0.3	0.3	-0.3	1.6	-0.5
Locomotor activity	0.5	0.8	1.5	-0.8	-0.8	0.9	-1.2	-0.3
Locomotor testing distance	0.9	1.4	2.1	-1.2	-1.2	1.3	-1.5	-0.8
Locomotor testing rearing	1.9	3.0	8.3	-1.4	-1.4	1.6	-2.9	-0.2
Light reinforcement 1	0.2	0.3	0.5	-0.6	-0.6	0.7	-0.5	-0.5
Light reinforcement 2	6.5	8.5	11.4	-3.2	-3.2	3.0	-1.4	-3.4
Reaction time number correct	0.1	0.1	0.1	0.3	0.3	-0.4	0.3	0.3
Reaction time mean minus median	0.3	0.4	0.9	0.5	0.6	-0.6	0.9	0.2
Reaction time mean minus median AUC	0.6	0.7	2.1	0.7	0.8	-0.6	1.4	0.1
Reaction time num false alarms	0.8	1.1	1.3	-1.1	-1.1	1.2	-1.1	-0.9
Reaction time num false alarms AUC	1.1	1.6	1.9	-1.2	-1.3	1.4	-1.2	-1.1
Reaction time trials correct on left	0.1	0.1	0.1	0.3	0.3	-0.4	0.3	0.3
Reaction time trials on left	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.2
Reaction time mean	0.1	0.2	0.4	-0.3	-0.2	0.1	0.6	-0.7
Reaction time mean AUC	0.3	0.4	1.0	-0.5	-0.3	0.3	0.8	-1.0
Median of all reaction times	0.2	0.3	0.7	-0.6	-0.4	0.4	0.3	-0.8
Reaction time omissions	0.1	0.1	0.2	-0.5	-0.3	0.2	-0.1	-0.5
Reaction time false alarm rate	1.1	1.6	2.0	-1.3	-1.3	1.4	-1.1	-1.2
Reaction time premature initiation rate	0.0	0.0	0.1	0.0	0.1	-0.0	-0.2	0.1
Reaction time premature initiations	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	0.2
Std. dev. reaction times	0.3	0.4	1.3	0.4	0.5	-0.5	1.1	-0.1
Reaction time trials completed	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.2
Reaction time trials AUC	0.0	0.0	0.1	0.2	0.2	-0.3	0.2	0.1
Social response proportion	4.6	5.0	6.6	2.3	2.3	-2.6	1.9	2.1
Social responses	0.1	0.2	0.8	0.1	0.2	-0.2	0.9	-0.1
Social time	0.2	0.3	0.8	0.5	0.5	-0.5	-0.0	0.9
Conditioned locomotion	0.8	0.9	2.7	0.8	0.8	-0.8	1.6	0.2
Cocaine response after cond. corrected	0.5	0.6	1.3	0.7	0.7	-0.8	1.1	0.3
Cocaine response after cond. not corrected	0.9	0.9	1.7	0.9	0.9	-1.0	1.3	0.5
Cocaine response before conditioning	1.7	2.1	2.5	1.6	1.5	-1.5	0.8	1.6
Saline control response	0.6	0.8	1.9	0.7	0.7	-0.7	-0.7	1.4
Condit. Reinf. active minus inactive responses	4.1	5.1	6.2	2.4	2.4	-2.5	1.5	2.4
Condit. Reinf. active-inactive response ratio	3.2	3.3	5.0	1.9	1.9	-2.0	0.5	2.2
Condit. Reinf. active responses	4.5	6.2	7.5	2.7	2.6	-2.7	1.8	2.5
Condit. Reinf. inactive responses	1.1	1.4	1.7	1.3	1.3	-1.2	0.8	1.2
Condit. Reinf. lever presses	6.1	8.5	9.6	3.1	3.0	-3.1	2.8	2.5
Condit. Reinf. lever reinforcers received	5.4	7.7	9.0	2.9	2.9	-3.0	2.3	2.6
Pavlov. Cond. lever latency	2.7	3.7	4.2	-2.1	-2.0	2.0	-1.8	-1.7
Pavlov. Cond. magazine entry latency	1.9	2.2	5.3	1.3	1.3	-1.3	2.3	0.5
Pavlov. Cond. change in total contacts	5.4	7.5	8.7	2.9	2.9	-2.9	2.1	2.7
Pavlov. Cond. index score	2.5	3.2	4.5	1.9	1.8	-1.8	2.1	1.3
Pavlov. Cond. latency score	2.4	3.1	4.8	1.8	1.7	-1.8	2.2	1.2
Pavlov. Cond. lever contacts	2.6	3.6	4.1	2.0	2.0	-2.0	1.7	1.7
Pavlov. Cond. magazine entry number	1.0	1.2	3.0	-1.0	-1.0	1.0	-1.7	-0.4
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.5	-0.9	-0.9	0.9	-0.1	-1.2
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.7	5.0	2.0	1.9	-2.0	2.2	1.4
Pavlov. Cond. response bias	3.0	4.1	4.6	2.2	2.1	-2.1	2.0	1.7
Conditioned reinforcement - actives	0.4	0.4	1.1	0.5	0.5	-0.6	1.1	0.2
Conditioned reinforcement - inactives	2.2	2.5	4.4	1.5	1.6	-1.5	2.1	0.9
Conditioned locomotion	0.9	1.0	1.8	-1.2	-1.2	0.8	-0.2	-1.4
Intermittent access intake day 1-15 change	1.0	1.0	1.4	1.1	1.0	-1.0	0.5	1.2
Intermittent access intake escalation	0.7	0.7	0.9	0.8	0.8	-0.8	0.5	0.9
Intermittent access intake escalation 2	2.9	2.9	5.4	1.7	1.7	-1.7	0.1	2.3
Intermitt. access day 1 inactive lever presses	0.7	0.8	3.3	0.4	0.4	-0.4	1.8	-0.4
Intermitt. access day 15 inactive lever presses	0.7	0.8	3.3	0.3	0.3	-0.3	1.8	-0.6
Intermitt. access escalation Index	0.2	0.2	0.4	0.4	0.4	-0.5	-0.2	0.6
Intermittent access day 1 total infusions	0.4	0.5	1.7	0.1	0.1	-0.4	1.3	-0.6
Intermittent access day 15 total infusions	1.1	1.2	2.0	1.0	1.0	-1.2	1.4	0.6
Intermittent access terminal intake (last 3 days)	1.6	1.8	2.2	1.3	1.3	-1.5	1.4	1.0
Intermittent access total infusions	0.9	1.0	2.5	0.8	0.8	-1.1	1.6	0.3
Intermittent access day 1 locomotion	0.4	0.4	1.5	0.0	0.0	-0.3	1.2	-0.6
Intermittent access day 15 total locomotion	0.2	0.2	0.5	-0.2	-0.2	0.0	0.7	-0.6
Intermittent access total locomotion	0.5	0.5	1.2	-0.7	-0.7	0.5	0.5	-1.1
Intermittent access standard deviation	4.1	4.4	6.4	2.2	2.2	-2.3	0.8	2.5
Cocaine induced anxiety	0.1	0.1	0.3	0.1	0.1	0.1	-0.5	0.2
Post-drug Anxiety	0.5	0.5	1.0	-0.6	-0.6	0.8	-1.0	-0.5
Baseline Anxiety	0.1	0.1	0.1	-0.3	-0.3	0.2	0.0	-0.3
Lifetime Intake	0.3	0.3	1.3	0.3	0.3	-0.6	1.1	-0.2
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.0	-0.0	0.3	0.7	-0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.2	-0.2	0.5	0.5	-0.6
Progressive ratio test 1 active lever presses	2.2	2.3	4.8	1.3	1.3	-1.6	2.2	0.7
Progressive ratio test 1 breakpoint	2.7	2.8	5.1	1.6	1.6	-1.7	2.3	0.9
Progressive ratio test 1 inactive lever presses	0.6	0.6	2.5	0.5	0.5	-0.5	1.6	-0.2
Progressive ratio test 2 active lever presses	1.0	1.0	3.2	0.8	0.8	-0.8	1.8	0.1
Progressive ratio test 2 breakpoint	1.1	1.2	3.9	0.8	0.8	-0.9	2.0	0.0
Progressive ratio test 2 inactive lever presses	2.7	3.2	5.9	1.7	1.7	-1.8	2.4	1.0
Total sessions with >9 infusions	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.1	0.0
Short access day 1 total inactive lever presses	0.5	0.6	1.6	0.6	0.6	-0.6	1.3	0.1
Short access day 10 total inactive lever presses	0.3	0.3	1.2	0.3	0.3	-0.4	1.1	-0.2
Short access day 1 total infusions	0.5	0.5	1.1	0.6	0.7	-0.7	1.0	0.3
Short access day 10 total infusions	0.1	0.1	0.2	-0.2	-0.2	-0.0	0.4	-0.5
Short access total infusions	0.1	0.1	0.3	-0.2	-0.3	0.1	0.5	-0.6
Short access day 1 locomotion	1.2	1.3	1.7	-1.1	-1.3	1.3	-1.0	-1.0
Short access day 10 total locomotion	0.4	0.4	0.7	0.5	0.5	-0.8	0.9	0.4
Short access total locomotion	0.1	0.1	0.2	-0.3	-0.4	0.3	0.1	-0.5
Compulsive drug intake	0.4	0.4	1.0	0.5	0.5	-0.6	-0.5	1.0
One hour access (0.3 mA shock)	1.2	1.4	2.2	1.1	1.1	-1.5	1.2	0.9
One hour access (shock baseline)	0.4	0.4	1.4	0.4	0.4	-0.6	1.2	-0.1
Number of responses in last shaping day	2.4	2.5	2.7	1.7	1.6	-1.7	1.5	1.4
Context. condit. distance diff. score	0.0	0.1	0.1	-0.3	-0.2	0.1	-0.4	-0.2
Locomotion velocity, session 1	2.4	2.6	3.3	-1.7	-1.6	1.6	-1.8	-1.2
Locomotion distance, session 1	0.7	0.9	1.1	1.0	1.0	-1.0	0.9	0.9
Locomotion velocity, session 2	0.3	0.4	0.6	-0.8	-0.7	0.6	-0.6	-0.5
Locomotion distance, session 2	0.5	0.8	2.1	-0.8	-0.7	0.8	-1.5	-0.2
Locomotion velocity, session 3	0.6	0.7	1.8	-0.3	-0.3	0.3	1.4	-1.2
Locomotion distance, session 3	5.9	6.4	7.2	2.6	2.6	-2.7	2.7	2.0
Stereotopy head waving bouts, day 3	0.3	0.4	1.2	-0.6	-0.4	0.5	-1.1	-0.2
Stereotopy head waving duration, day 3	2.2	2.6	2.9	-1.7	-1.6	1.7	-1.7	-1.4
Locomotion velocity, session 7	0.2	0.2	0.8	-0.2	-0.0	-0.0	0.9	-0.5
Locomotion distance, session 7	0.2	0.2	0.9	0.2	0.3	-0.3	0.9	-0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.2	-0.1	0.0	-0.5	0.1
Stereotopy head waving duration, day 7	0.9	1.1	2.4	-1.0	-1.0	0.9	-1.5	-0.5
Locomotion velocity, session 8	2.4	2.9	3.8	-1.9	-1.7	1.8	-1.0	-2.0
Locomotion distance, session 8	0.4	0.6	2.0	-0.7	-0.5	0.5	-1.4	-0.1
Degree of sensitization distance	3.3	3.3	3.9	-2.0	-1.9	2.0	-1.5	-1.8
Degree of sensitization stereotypy	0.1	0.1	0.5	-0.0	-0.0	-0.1	-0.7	0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.4	-0.4	0.3	-0.0	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.3	-0.4
Condit. Reinf. active responses	0.9	1.0	1.5	-1.1	-1.1	1.0	-0.4	-1.2
Condit. Reinf. inactive responses	0.7	0.8	1.1	-1.0	-1.0	1.0	-0.5	-0.9
Incentive salience index mean	0.2	0.2	0.6	-0.1	-0.0	-0.0	0.8	-0.6
Condit. Reinf. lever presses	0.2	0.3	1.0	0.4	0.4	-0.4	1.0	-0.0
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.4	0.5	-0.5	-0.1	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.1	-0.3
Total zone transitions, hab. session 1	0.7	0.9	2.3	0.8	0.8	-0.8	-0.7	1.5
Total locomotion distance, hab. session 1	2.7	3.9	7.5	2.0	2.0	-2.0	-0.1	2.7
Locomotion velocity, hab. session 1	1.2	1.8	3.7	1.3	1.3	-1.3	-0.4	1.9
Time in familiar zone, hab. session 2	0.3	0.4	0.5	0.6	0.7	-0.7	0.5	0.5
Time in novel zone, hab. session 2	0.6	0.6	0.7	-0.7	-0.8	0.9	-0.7	-0.6
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.2	0.0
Total locomotion distance, hab. session 2	0.5	0.7	1.1	0.8	0.9	-0.9	-0.0	1.1
Locomotion velocity, hab. session 2	0.4	0.6	1.0	0.8	0.8	-0.9	-0.0	1.0
Novel to familiar place preference ratio	1.1	1.1	2.7	1.0	1.0	-0.9	-0.3	1.6
Novelty place preference	0.9	0.9	2.1	1.0	0.9	-0.9	-0.1	1.4
Time in novel zone, NPP test	0.6	0.6	1.6	0.7	0.7	-0.6	-0.3	1.2
Total zone transitions, NPP test	0.2	0.2	0.3	-0.6	-0.5	0.4	-0.4	-0.4
Total locomotion distance, NPP test	1.4	2.0	3.4	1.4	1.5	-1.5	0.1	1.9
Locomotion velocity, NPP test	1.8	2.6	4.3	1.6	1.7	-1.8	0.3	2.1
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.5	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.4	-0.3	0.3	0.1	-0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.0	0.0	-0.0	0.2	-0.1
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.1	-0.1	0.4	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	0.2	0.3	-0.3	0.4	0.1
Pavlov. Cond. lever contacts	0.8	0.9	1.3	0.9	1.0	-1.0	1.2	0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	0.2	-0.1	0.0	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.3	-0.3	0.4	-0.8	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.3	0.4	-0.4	0.6	0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.3	0.4	-0.4	0.6	0.1
Bone: apparent density	0.2	0.3	0.6	-0.4	-0.4	0.5	0.5	-0.8
Bone surface	0.3	0.6	2.2	0.5	0.5	-0.5	1.5	-0.1
Bone volume	0.3	0.5	2.0	0.5	0.5	-0.5	1.4	-0.0
Bone: connectivity density	0.6	1.0	1.6	-1.0	-1.1	1.0	-0.1	-1.2
Bone: cortical apparent density	2.1	2.8	5.1	-1.7	-1.6	1.6	-2.3	-1.0
Bone: cortical area	2.1	3.1	4.0	1.8	2.0	-1.9	1.1	1.9
Bone: cortical porosity	0.5	0.5	0.6	-0.7	-0.8	0.7	-0.7	-0.6
Bone: cortical porosity	0.5	0.5	0.6	-0.8	-0.8	0.7	-0.7	-0.7
Bone: cortical thickness	1.0	1.6	2.2	1.3	1.5	-1.3	0.7	1.3
Bone: cortical thickness	0.0	0.0	0.1	-0.2	-0.0	0.0	0.2	-0.3
Bone: cortical tissue density	2.5	3.2	5.4	-1.8	-1.7	1.8	-2.3	-1.2
Bone: elastic displacement	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.0	-0.3
Bone: elastic work	2.3	2.9	3.5	1.7	1.8	-1.8	1.9	1.3
Bone: endosteal estimation	0.9	2.0	3.0	1.5	1.5	-1.5	0.6	1.7
Bone: endosteal perimeter	0.8	1.7	1.9	1.4	1.4	-1.3	1.0	1.3
Bone: final force	1.7	2.8	3.5	1.7	1.9	-1.8	1.4	1.6
Bone: final moment	2.5	4.1	5.1	2.1	2.3	-2.1	1.8	1.8
Bone: marrow area	1.0	2.1	3.2	1.5	1.6	-1.5	0.6	1.8
Bone: maximum diameter	1.3	2.5	2.9	1.6	1.7	-1.6	1.7	1.2
Bone: maximum force	2.7	4.7	5.8	2.3	2.4	-2.3	1.4	2.3
Bone: maximum moment	3.6	6.2	7.6	2.6	2.8	-2.7	1.7	2.5
Bone: minimum diameter	5.3	9.9	15.2	3.3	3.4	-3.3	0.9	3.9
Bone: periosteal estimation	1.8	3.8	5.1	2.0	2.2	-2.0	1.0	2.3
Bone: periosteal perimeter	1.5	2.5	3.3	1.7	1.7	-1.6	0.9	1.8
Bone: post-yield work	0.6	0.8	1.2	0.9	1.0	-1.0	0.2	1.1
Bone: stiffness	1.4	2.3	3.1	1.5	1.7	-1.7	0.5	1.8
Bone: tissue strength	4.0	3.8	4.5	2.1	2.0	-2.1	1.5	2.0
Bone: trabecular number	0.1	0.1	0.4	0.2	0.2	-0.2	0.6	0.0
Bone: trabecular spacing	1.6	2.1	3.2	1.5	1.5	-1.6	0.5	1.8
Bone: trabecular thickness	0.4	0.4	1.0	-0.5	-0.4	0.5	0.8	-1.0
Bone: trabecular tissue density	2.4	3.3	3.9	-2.0	-1.9	2.0	-1.7	-1.6
Breakpoint value in progressive ratio session	1.7	1.9	4.1	1.2	1.4	-1.2	-0.7	2.0
Distance traveled before self-admin	1.9	2.1	2.5	1.6	1.4	-1.5	1.2	1.4
Distance traveled after self-admin	4.6	5.1	5.9	2.4	2.3	-2.4	2.0	2.2
Delta time in closed arm before/after self-admin	0.6	0.6	1.9	0.5	0.6	-0.5	1.4	0.1
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.1	-0.0
Diff in mean of infusions in LGA sessions	0.3	0.4	0.8	0.3	0.4	-0.3	-0.9	0.9
Extinction: sum of active levers before priming	1.1	1.1	2.6	1.0	1.1	-0.9	-0.4	1.6
Active lever presses in extinction session 6	0.2	0.2	0.5	0.4	0.6	-0.3	-0.2	0.7
Delta distance traveled before/after self-admin	0.2	0.3	0.3	0.5	0.6	-0.5	0.4	0.6
Delta ambulatory time before/after self-admin	0.8	0.9	1.2	0.9	1.0	-1.0	0.6	1.1
Time in closed arm before self-admin	0.0	0.0	0.1	-0.0	-0.1	-0.2	-0.3	-0.0
Time in closed arm after self-admin	0.4	0.4	1.4	0.3	0.3	-0.6	1.2	-0.2
Time in open arm before self-admin	1.0	1.1	1.4	1.0	1.2	-0.9	1.1	0.9
Time in open arm after self-admin	0.9	1.0	1.8	1.1	1.2	-0.7	0.3	1.3
Sum of active levers in priming session hrs 5-6	1.3	1.3	4.3	0.2	0.4	-0.1	-2.1	1.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.0	0.4	0.3	-0.5	1.0	-0.1
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.3	0.4	0.2	-0.5	1.1	-0.1
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.3	0.2	-0.2	0.0	0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.2	0.2	-0.2	0.4	-0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.2	0.2	-0.2	0.4	0.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.0	0.0	-0.0	0.4	-0.2
Ambulatory time before self-admin	1.0	1.1	1.4	1.2	1.0	-1.1	0.7	1.1
Ambulatory time after self-admin	4.9	5.4	6.4	2.5	2.3	-2.5	2.0	2.3
Total heroin consumption	2.3	2.8	6.1	1.5	1.6	-1.2	-1.2	2.5
Area under the delay curve	0.1	0.1	0.2	0.0	0.1	-0.0	-0.5	0.2
Delay disc. indifference point, 0s delay	0.6	0.6	1.4	0.5	0.7	-0.6	-0.7	1.2
Delay disc. indifference point, 16s delay	0.9	0.9	1.1	1.0	1.0	-1.0	1.0	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.3	-0.1	0.1	-0.4	-0.1
Delay disc. indifference point, 24s delay	1.1	1.0	1.8	1.1	1.0	-0.9	1.3	0.6
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.1	0.2	-0.2	-0.1	0.3
Delay disc. indifference point, 8s delay	1.2	1.2	2.8	-1.0	-0.9	1.0	-1.7	-0.5
Delay discount exponential model param	0.0	0.0	0.1	-0.1	-0.1	0.0	0.3	-0.2
Delay discount hyperbolic model param	0.0	0.0	0.2	0.1	0.0	-0.1	0.4	-0.1
Fecal boli incidents, locomotor time 1	3.5	3.8	5.7	-2.1	-2.1	2.1	-0.5	-2.4
Change in fecal boli incidents, locomotor task	0.9	0.8	1.8	0.5	0.5	-0.5	-1.3	1.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.1	-0.2	0.3	0.0	-0.2
Bouts of movement, locomotor time 1	0.1	0.2	0.4	0.4	0.2	-0.1	-0.4	0.6
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.3	0.1	0.0	-0.1	0.4
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.3	-0.3	0.3	0.3	-0.5
Distance moved, locomotor task time 1	0.2	0.2	0.4	0.4	0.4	-0.5	-0.1	0.6
Vertical activity count, locomotor time 1	1.1	1.2	1.9	1.1	1.2	-1.2	0.3	1.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.2	0.2	-0.0	-0.3	0.4
Bouts of movement, locomotor time 2	0.4	0.5	1.1	-0.5	-0.4	0.8	0.4	-1.0
Total resting periods, locomotor time 2	0.4	0.4	1.0	-0.4	-0.4	0.9	0.3	-1.0
Rest time, locomotor task time 2	0.3	0.4	0.6	0.6	0.5	-0.6	0.8	0.4
Distance moved, locomotor task time 2	0.2	0.2	1.0	-0.2	-0.2	0.2	-1.0	0.3
Vertical activity count, locomotor time 2	0.3	0.3	0.7	0.2	0.2	-0.1	-0.8	0.9
Weight adjusted by age	0.1	0.1	0.3	-0.4	-0.3	0.3	-0.5	-0.2
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	1.6	1.2	1.2	-1.1	0.7	1.3
Locomotion in novel chamber	0.7	0.8	2.3	-0.8	-0.8	0.8	-1.5	-0.1
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	0.0
Progressive ratio	0.7	0.8	1.8	-0.9	-0.8	0.7	-1.3	-0.3
Food seeking constrained by brief footshock	2.7	3.3	4.7	1.9	1.9	-2.0	0.7	2.2
Seeking ratio, punishment vs. effort	2.2	2.7	3.7	1.7	1.7	-1.7	1.9	1.2
Run reversals in cocaine runway, females	0.8	0.8	1.8	-0.6	-0.6	0.6	1.0	-1.3
Run reversals in cocaine runway, males	0.6	0.6	0.7	-0.8	-0.8	0.8	-0.7	-0.7
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.2	-0.2
Latency to leave start box in cocaine runway, F	0.4	0.4	0.9	-0.6	-0.6	0.7	-0.9	-0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	0.1	0.1	-0.2	0.7	-0.1
Cd content in liver	0.8	0.9	3.3	-0.6	-0.6	0.6	-1.8	0.1
Co content in liver	1.6	1.8	2.2	-1.5	-1.4	1.4	-0.9	-1.5
Cu content in liver	1.5	1.7	4.0	1.3	1.2	-1.1	2.0	0.6
Fe content in liver	0.4	0.5	1.0	-0.8	-0.7	0.7	0.1	-1.0
K content in liver	0.8	0.8	1.7	0.9	0.8	-0.7	1.3	0.4
Mg content in liver	0.3	0.3	1.3	0.3	0.3	-0.2	1.2	-0.3
Mn content in liver	0.6	0.7	1.0	0.9	0.9	-0.8	0.3	1.0
Na content in liver	4.9	5.2	5.9	2.4	2.4	-2.4	2.0	2.2
Rb content in liver	0.0	0.0	0.1	0.1	-0.1	0.0	0.2	-0.1
Se content in liver	2.6	3.2	3.8	-2.0	-1.7	1.9	-1.8	-1.5
Sr content in liver	0.6	0.5	0.7	-0.8	-0.8	0.7	-0.4	-0.8
Zn content in liver	0.4	0.4	0.9	-0.6	-0.5	0.6	0.3	-0.9