Hub : Genes

Metrnl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000046202 0.11 0.06 1.5e-05 0.06 0.05 0.06 0.05 3.1e-06 2.1e-05 5.6e-06 2.2e-05
2 Liver gene expression ENSRNOG00000046202 0.04 0.02 5.2e-06 0.04 0.04 0.04 0.03 1.4e-05 6.4e-05 8.4e-05 3.0e-04
3 OFC gene expression ENSRNOG00000046202 0.22 0.12 7.2e-03 0.16 0.07 0.18 0.12 1.7e-04 8.7e-03 5.4e-05 1.0e-03
4 PL gene expression ENSRNOG00000046202 0.05 0.03 9.3e-04 0.02 0.03 0.03 0.04 6.6e-03 1.8e-03 4.0e-03 8.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail1.13.710.00.6-1.73.2-1.3
BMI without tail1.83.812.40.6-3.51.6-0.2
Body weight1.87.616.91.8-4.12.5-2.0
Epididymis fat weight0.30.72.00.2-1.40.8-0.1
Glucose1.42.15.5-1.42.30.1-1.0
Heart weight1.92.86.00.3-1.82.5-1.4
Left kidney weight0.61.62.11.4-1.21.0-1.5
Right kidney weight0.31.02.21.5-0.90.7-0.6
Tail length1.33.915.10.7-3.9-0.3-0.2
Length with tail0.72.78.21.1-2.9-0.1-1.2
Length without tail0.30.71.90.60.60.3-1.4
Liver weight, left0.20.30.5-0.50.30.7-0.4
Liver weight, right0.71.23.10.6-1.80.9-0.7
Parametrial fat weight1.52.84.2-2.0-1.81.1-1.6
Retroperitoneal fat weight1.34.315.30.2-3.90.2-1.3
Intraocular pressure0.81.22.31.5-1.3-0.60.7
Extensor digitorum longus weight0.31.12.11.2-1.5-1.00.1
Soleus weight0.72.15.4-0.5-2.3-0.0-1.7
Tibialis anterior weight0.10.51.2-0.1-1.1-0.8-0.5
Tibia length6.217.435.41.1-5.92.9-5.0
Number of licking bursts0.20.30.7-0.0-0.60.90.1
Food consumed during 24 hour testing period0.40.50.6-0.6-0.7-0.8-0.7
Times rat made contact with spout3.13.57.5-2.7-1.1-0.7-2.2
Mean time between licks in bursts1.01.43.60.21.9-0.21.3
Mean num. licks in bursts1.21.42.7-1.2-0.2-1.6-1.2
Std. dev. time between licks in bursts1.61.93.71.9-0.6-0.11.9
Water consumed over 24 hours0.70.91.9-1.40.10.2-1.3
Indifference point 0 sec0.30.41.40.30.3-1.20.2
Indifference point AUC0.91.02.2-1.3-0.21.5-0.5
Indifference point function ln k0.91.32.51.60.8-0.81.2
Indifference point function log k0.91.32.51.60.8-0.81.2
Delay discounting total patch changes 0 sec0.30.51.40.40.3-1.20.4
Delay discounting total patch changes 12 sec0.60.82.5-1.60.40.0-0.6
Delay discounting total patch changes 18 sec0.20.30.80.50.40.10.9
Delay discounting total patch changes 24 sec0.00.00.00.10.0-0.2-0.2
Delay discounting total patch changes 6 sec0.40.61.4-1.2-0.30.2-0.9
Delay discounting time to switch 0 sec1.11.76.20.10.6-2.50.4
Delay discounting water rate 0 sec1.42.28.20.1-0.72.90.4
Delay discounting water rate 12 sec0.71.14.00.5-0.22.00.4
Delay discounting water rate 18 sec1.31.73.51.9-0.91.30.9
Delay discounting water rate 24 sec1.72.35.62.4-1.21.01.0
Delay discounting water rate 6 sec2.03.09.41.10.33.11.1
Locomotor activity0.40.61.10.31.00.51.0
Locomotor testing distance1.32.14.91.30.7-2.21.1
Locomotor testing rearing0.50.81.7-0.11.1-0.41.3
Light reinforcement 12.34.211.5-0.9-1.5-3.4-1.4
Light reinforcement 20.91.12.6-0.4-1.6-0.6-1.2
Reaction time number correct1.92.75.02.2-0.60.82.2
Reaction time mean minus median0.40.51.1-1.00.80.6-0.1
Reaction time mean minus median AUC0.00.10.1-0.20.20.4-0.0
Reaction time num false alarms0.91.34.70.5-0.1-2.2-0.3
Reaction time num false alarms AUC1.21.76.40.50.3-2.50.2
Reaction time trials correct on left1.92.75.02.2-0.60.82.2
Reaction time trials on left2.02.85.22.3-0.60.82.3
Reaction time mean0.20.30.4-0.5-0.60.4-0.6
Reaction time mean AUC0.10.20.60.1-0.80.4-0.1
Median of all reaction times0.20.30.6-0.2-0.80.4-0.5
Reaction time omissions0.10.20.5-0.20.10.40.7
Reaction time false alarm rate1.42.06.3-0.70.5-2.5-1.0
Reaction time premature initiation rate0.40.50.8-0.90.9-0.70.2
Reaction time premature initiations0.50.72.10.50.4-0.41.4
Std. dev. reaction times0.10.10.3-0.20.50.10.4
Reaction time trials completed2.02.85.22.3-0.60.82.3
Reaction time trials AUC1.92.75.02.2-0.60.92.1
Social response proportion1.41.52.71.71.1-0.11.5
Social responses1.11.54.21.00.6-2.00.6
Social time0.70.91.81.3-0.1-1.20.4
Conditioned locomotion2.22.67.10.6-2.7-1.5-0.8
Cocaine response after cond. corrected0.30.30.6-0.40.80.6-0.2
Cocaine response after cond. not corrected0.40.51.5-0.01.20.30.5
Cocaine response before conditioning1.01.33.21.10.8-0.41.8
Saline control response0.70.92.10.0-1.4-1.2-0.4
Condit. Reinf. active minus inactive responses1.51.83.01.6-1.7-1.0-1.0
Condit. Reinf. active-inactive response ratio2.32.44.70.2-2.1-0.4-2.2
Condit. Reinf. active responses1.01.43.01.7-1.0-1.2-0.2
Condit. Reinf. inactive responses1.11.42.41.50.8-0.71.4
Condit. Reinf. lever presses0.20.30.50.7-0.60.10.5
Condit. Reinf. lever reinforcers received1.11.53.21.8-1.1-1.3-0.0
Pavlov. Cond. lever latency0.40.51.5-0.81.20.2-0.1
Pavlov. Cond. magazine entry latency1.41.64.50.61.20.22.1
Pavlov. Cond. change in total contacts0.81.12.61.60.1-0.31.3
Pavlov. Cond. index score0.40.51.70.70.10.01.3
Pavlov. Cond. latency score0.40.51.50.8-0.1-0.11.2
Pavlov. Cond. lever contacts0.50.72.10.9-1.4-0.10.2
Pavlov. Cond. magazine entry number1.41.85.3-0.7-1.20.1-2.3
Pavlov. Cond. intertrial magazine entries0.71.02.70.6-1.70.3-0.8
Pavlov. Cond. lever-magazine prob. diff.0.50.62.00.70.20.01.4
Pavlov. Cond. response bias0.30.30.80.7-0.40.10.9
Conditioned reinforcement - actives0.30.31.1-0.3-0.1-0.21.0
Conditioned reinforcement - inactives1.01.23.8-0.9-0.22.00.2
Conditioned locomotion0.50.62.10.30.2-0.31.5
Intermittent access intake day 1-15 change0.80.82.5-0.90.11.60.3
Intermittent access intake escalation0.70.71.9-0.70.21.40.6
Intermittent access intake escalation 22.42.38.5-0.90.12.90.0
Intermitt. access day 1 inactive lever presses0.50.51.1-0.2-0.10.9-1.0
Intermitt. access day 15 inactive lever presses1.21.32.61.3-0.51.60.8
Intermitt. access escalation Index2.52.27.10.1-1.0-2.7-0.8
Intermittent access day 1 total infusions0.40.41.2-0.1-1.1-0.7-0.1
Intermittent access day 15 total infusions0.10.10.3-0.5-0.50.10.2
Intermittent access terminal intake (last 3 days)0.40.41.1-1.1-0.50.4-0.2
Intermittent access total infusions0.20.30.5-0.3-0.7-0.70.1
Intermittent access day 1 locomotion0.50.50.90.60.1-1.00.8
Intermittent access day 15 total locomotion0.10.10.30.2-0.10.60.1
Intermittent access total locomotion0.10.10.20.50.20.10.5
Intermittent access standard deviation2.62.87.0-0.81.52.61.0
Cocaine induced anxiety3.13.68.5-1.5-0.51.8-2.9
Post-drug Anxiety0.60.61.1-0.40.61.1-0.9
Baseline Anxiety4.44.78.62.31.9-1.22.9
Lifetime Intake0.20.30.7-0.8-0.2-0.50.1
Incentive Sensitization - Responses0.60.61.2-0.7-1.10.2-0.7
Incentive Sensitization - Breakpoint0.50.50.9-0.7-1.00.2-0.7
Progressive ratio test 1 active lever presses0.10.20.30.3-0.5-0.60.0
Progressive ratio test 1 breakpoint0.30.30.70.1-0.9-0.5-0.4
Progressive ratio test 1 inactive lever presses0.10.10.40.0-0.60.1-0.4
Progressive ratio test 2 active lever presses0.20.20.4-0.3-0.70.40.1
Progressive ratio test 2 breakpoint0.20.20.7-0.1-0.80.30.1
Progressive ratio test 2 inactive lever presses0.30.31.10.2-0.11.1-0.1
Total sessions with >9 infusions0.20.30.50.10.4-0.50.7
Short access day 1 total inactive lever presses0.60.72.50.4-0.3-1.6-0.1
Short access day 10 total inactive lever presses1.11.22.1-0.8-1.41.1-0.9
Short access day 1 total infusions0.70.72.0-0.71.4-0.30.5
Short access day 10 total infusions0.30.31.1-1.1-0.3-0.1-0.3
Short access total infusions0.50.52.0-1.40.10.1-0.3
Short access day 1 locomotion0.40.40.6-0.60.7-0.2-0.7
Short access day 10 total locomotion1.11.22.0-1.41.30.6-0.8
Short access total locomotion0.60.61.0-0.81.0-0.1-0.7
Compulsive drug intake0.30.31.00.3-1.00.4-0.2
One hour access (0.3 mA shock)0.80.92.2-1.1-1.50.6-0.3
One hour access (shock baseline)0.50.61.2-0.8-0.8-1.1-0.2
Number of responses in last shaping day0.50.51.80.2-0.31.3-0.1
Context. condit. distance diff. score0.40.50.90.7-1.0-0.60.6
Locomotion velocity, session 11.31.42.5-1.61.50.1-0.9
Locomotion distance, session 11.11.42.31.51.00.01.5
Locomotion velocity, session 22.02.45.70.52.40.71.7
Locomotion distance, session 21.42.03.21.50.21.81.6
Locomotion velocity, session 31.72.04.20.62.11.41.1
Locomotion distance, session 32.93.26.01.12.41.41.9
Stereotopy head waving bouts, day 30.10.20.40.00.3-0.6-0.4
Stereotopy head waving duration, day 30.40.41.50.5-0.1-1.2-0.1
Locomotion velocity, session 70.60.71.20.81.00.11.1
Locomotion distance, session 72.53.16.40.92.11.12.5
Stereotopy head waving bouts, day 70.60.71.30.7-1.1-0.8-0.5
Stereotopy head waving duration, day 70.70.91.30.6-1.2-1.1-0.7
Locomotion velocity, session 81.31.64.12.00.4-0.71.3
Locomotion distance, session 82.33.46.02.5-1.01.52.1
Degree of sensitization distance0.20.20.7-0.5-0.8-0.1-0.1
Degree of sensitization stereotypy0.40.41.20.6-1.1-0.1-0.4
Condit. Reinf. active minus inactive responses1.01.13.00.2-1.70.5-1.0
Condit. Reinf. active-inactive response ratio0.70.71.41.2-1.00.5-0.5
Condit. Reinf. active responses1.72.15.8-0.5-2.40.7-1.3
Condit. Reinf. inactive responses0.91.02.0-1.4-1.20.0-0.8
Incentive salience index mean0.70.82.40.2-1.60.5-0.6
Condit. Reinf. lever presses0.10.10.4-0.00.00.20.7
Time in familiar zone, hab. session 10.40.40.9-0.90.10.3-0.7
Time in novel zone, hab. session 10.40.41.5-0.20.1-1.20.1
Total zone transitions, hab. session 10.40.51.60.10.41.30.7
Total locomotion distance, hab. session 10.20.30.80.3-0.90.40.3
Locomotion velocity, hab. session 10.40.61.00.5-1.01.00.4
Time in familiar zone, hab. session 20.40.41.0-0.40.5-1.00.3
Time in novel zone, hab. session 20.20.20.40.60.10.50.2
Total zone transitions, hab. session 20.70.91.60.9-0.61.30.8
Total locomotion distance, hab. session 20.60.72.60.5-1.60.10.3
Locomotion velocity, hab. session 20.71.03.40.7-1.80.30.2
Novel to familiar place preference ratio2.02.15.2-1.0-1.50.3-2.3
Novelty place preference2.12.25.6-0.9-1.50.2-2.4
Time in novel zone, NPP test1.71.84.6-0.9-1.30.0-2.1
Total zone transitions, NPP test1.31.94.31.8-0.1-0.12.1
Total locomotion distance, NPP test1.11.52.71.2-0.9-0.91.7
Locomotion velocity, NPP test0.81.11.41.1-1.1-0.81.2
Pavlov. Cond. lever latency2.02.55.02.20.6-0.12.2
Pavlov. Cond. magazine entry latency1.62.14.9-1.6-0.90.3-2.2
Pavlov. Cond. change in total contacts1.11.22.8-1.70.10.3-1.3
Pavlov. Cond. index score2.22.85.6-1.7-1.50.5-2.4
Pavlov. Cond. latency score2.32.95.9-2.0-1.30.4-2.4
Pavlov. Cond. lever contacts0.81.01.8-1.4-0.6-0.0-1.3
Pavlov. Cond. magazine entry number2.43.06.32.10.8-0.72.5
Pavlov. Cond. intertrial magazine entries0.20.30.80.1-0.90.40.1
Pavlov. Cond. lever-magazine prob. diff.2.12.65.2-1.5-1.40.9-2.3
Pavlov. Cond. response bias1.92.34.9-1.9-0.80.4-2.2
Bone: apparent density0.10.20.40.6-0.6-0.1-0.2
Bone surface0.30.50.90.7-1.0-0.6-0.4
Bone volume0.20.30.70.3-0.8-0.3-0.5
Bone: connectivity density0.50.81.41.1-0.2-1.20.7
Bone: cortical apparent density1.41.85.6-0.62.4-0.50.9
Bone: cortical area5.38.012.92.2-3.63.0-2.3
Bone: cortical porosity2.72.96.0-1.3-0.52.4-2.0
Bone: cortical porosity2.83.06.7-1.1-0.82.6-1.9
Bone: cortical thickness5.69.216.51.0-3.14.1-3.1
Bone: cortical thickness2.83.36.6-0.4-1.52.6-2.0
Bone: cortical tissue density1.62.16.4-0.92.5-0.70.9
Bone: elastic displacement0.91.11.4-0.3-1.11.2-1.2
Bone: elastic work6.28.015.9-1.0-3.02.5-4.0
Bone: endosteal estimation0.81.74.02.0-0.6-1.11.1
Bone: endosteal perimeter0.71.42.41.5-1.4-1.0-0.5
Bone: final force4.87.912.22.0-3.43.5-2.0
Bone: final moment5.28.613.31.8-3.63.4-2.5
Bone: marrow area0.81.74.22.0-0.5-1.01.1
Bone: maximum diameter1.52.85.02.2-2.01.3-0.7
Bone: maximum force5.08.714.62.2-3.83.3-2.1
Bone: maximum moment5.39.316.62.0-4.13.1-2.6
Bone: minimum diameter1.63.06.81.3-2.60.5-1.9
Bone: periosteal estimation2.04.07.12.6-2.71.1-0.9
Bone: periosteal perimeter2.13.46.11.2-2.50.8-2.4
Bone: post-yield work0.71.03.31.8-0.2-0.00.7
Bone: stiffness2.13.36.62.0-1.72.6-0.3
Bone: tissue strength3.13.04.82.2-1.52.10.3
Bone: trabecular number0.20.20.6-0.4-0.2-0.7-0.4
Bone: trabecular spacing2.02.65.12.3-0.4-0.72.1
Bone: trabecular thickness2.22.77.1-1.8-0.4-0.4-2.7
Bone: trabecular tissue density0.91.32.31.11.20.51.5
Breakpoint value in progressive ratio session0.30.30.60.20.70.70.1
Distance traveled before self-admin2.93.112.50.3-0.13.5-0.0
Distance traveled after self-admin0.80.92.5-0.7-0.30.81.6
Delta time in closed arm before/after self-admin0.40.40.6-0.80.0-0.5-0.8
Delta time in open arm before/after self-admin0.40.40.9-0.10.80.31.0
Diff in mean of infusions in LGA sessions0.80.91.8-0.11.3-1.30.4
Extinction: sum of active levers before priming1.61.62.4-1.01.41.6-0.9
Active lever presses in extinction session 62.62.54.80.52.22.00.9
Delta distance traveled before/after self-admin2.52.67.3-0.80.7-2.71.5
Delta ambulatory time before/after self-admin4.04.413.3-0.91.2-3.61.4
Time in closed arm before self-admin0.20.30.40.30.60.40.6
Time in closed arm after self-admin0.60.61.7-0.91.30.1-0.2
Time in open arm before self-admin1.11.11.90.2-0.9-1.3-1.4
Time in open arm after self-admin0.10.10.30.50.10.0-0.1
Sum of active levers in priming session hrs 5-60.70.71.5-1.20.11.0-0.7
Time to tail flick, vehicle, before self-admin0.80.82.40.1-0.51.50.6
Time to tail flick, vehicle, after self-admin0.30.30.80.40.90.10.5
Time to tail flick, test, before self-admin0.80.81.3-0.71.1-0.61.1
Time to tail flick, test, after self-admin1.41.53.1-0.41.8-0.51.5
Delta time to tail flick, vehicle, before/after SA0.30.20.4-0.60.3-0.7-0.3
Delta time to tail flick, test, before/after SA0.20.20.4-0.20.7-0.0-0.6
Ambulatory time before self-admin2.42.59.60.2-0.63.1-0.3
Ambulatory time after self-admin0.30.31.2-0.30.20.01.1
Total heroin consumption0.50.61.81.30.7-0.3-0.3
Area under the delay curve1.31.32.80.81.70.11.4
Delay disc. indifference point, 0s delay0.20.20.90.9-0.10.1-0.1
Delay disc. indifference point, 16s delay2.52.67.11.31.20.02.7
Delay disc. indifference point, 2s delay0.30.40.70.50.70.80.3
Delay disc. indifference point, 24s delay2.52.46.10.82.50.21.7
Delay disc. indifference point, 4s delay0.70.71.70.81.30.40.6
Delay disc. indifference point, 8s delay0.50.51.70.21.3-0.40.2
Delay discount exponential model param1.61.74.3-0.7-2.1-0.3-1.4
Delay discount hyperbolic model param1.61.74.1-0.7-2.0-0.5-1.4
Fecal boli incidents, locomotor time 10.40.41.10.20.21.10.6
Change in fecal boli incidents, locomotor task1.91.84.3-1.52.1-0.9-0.0
Time >=10cm from walls, locomotor time 11.81.84.41.5-0.3-2.10.8
Bouts of movement, locomotor time 10.20.20.5-0.60.7-0.2-0.2
Total resting periods, locomotor time 10.30.40.9-0.80.9-0.1-0.2
Rest time, locomotor task time 10.40.40.8-0.9-0.10.9-0.2
Distance moved, locomotor task time 10.80.91.50.80.9-0.71.2
Vertical activity count, locomotor time 10.70.71.31.1-0.0-1.20.6
Time >=10cm from walls, locomotor time 20.60.61.00.5-0.9-0.5-1.0
Bouts of movement, locomotor time 20.80.92.30.51.0-1.50.3
Total resting periods, locomotor time 20.80.92.50.70.6-1.60.6
Rest time, locomotor task time 20.50.61.8-0.6-0.2-1.3-0.2
Distance moved, locomotor task time 20.20.20.50.10.30.70.5
Vertical activity count, locomotor time 20.70.82.21.5-0.30.40.9
Weight adjusted by age1.61.84.70.4-2.2-0.6-1.4
Seeking ratio, delayed vs. immediate footshock0.30.30.8-0.2-0.9-0.6-0.3
Locomotion in novel chamber0.20.31.11.0-0.20.30.1
Locomotion in novel chamber post-restriction1.21.43.7-0.4-1.90.1-1.3
Progressive ratio0.91.12.41.60.70.71.0
Food seeking constrained by brief footshock0.60.71.7-0.50.61.3-0.7
Seeking ratio, punishment vs. effort0.60.81.2-1.0-0.4-0.8-1.1
Run reversals in cocaine runway, females0.70.72.10.50.1-0.71.4
Run reversals in cocaine runway, males1.01.01.8-1.3-0.60.4-1.2
Latency to leave start box in cocaine runway0.60.71.80.00.2-0.91.3
Latency to leave start box in cocaine runway, F0.91.01.80.7-0.2-1.41.3
Latency to leave start box in cocaine runway, M0.40.41.1-1.1-0.0-0.30.6
Cd content in liver1.01.12.10.41.40.91.1
Co content in liver0.20.30.40.60.5-0.00.7
Cu content in liver0.50.50.8-0.90.00.9-0.8
Fe content in liver1.51.83.21.41.4-0.11.8
K content in liver1.91.96.4-0.2-0.92.50.3
Mg content in liver1.91.95.00.00.12.21.7
Mn content in liver2.63.011.7-0.5-0.33.4-0.0
Na content in liver0.40.51.30.10.61.20.4
Rb content in liver0.50.61.50.6-1.20.80.3
Se content in liver0.20.31.1-1.0-0.1-0.2-0.1
Sr content in liver1.00.91.7-1.20.40.7-1.3
Zn content in liver0.30.30.50.70.2-0.70.6