Hub : Genes

ENSRNOG00000045615

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000045615	0.06	0.04	1.2e-09	0.07	0.07	0.07	0.07	2.9e-08	9.6e-09	1.0e-08	1.4e-08
2	Brain	intron excision ratio	chr10:103098301:103099841	0.03	0.03	6.5e-04	0.02	0.02	0.03	0.02	5.9e-03	2.6e-03	1.6e-03	4.9e-03
3	Liver	gene expression	ENSRNOG00000045615	0.04	0.03	1.2e-07	0.06	0.06	0.06	0.05	1.0e-06	6.6e-07	5.7e-07	1.2e-06
4	Liver	mRNA stability	ENSRNOG00000045615	0.02	0.02	4.9e-03	0.01	0.01	0.01	0.01	1.3e-02	3.9e-02	2.4e-02	3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	0.1	0.3	0.6	0.2	0.1	-0.8	0.8
BMI without tail	1.2	2.4	3.5	-1.5	1.7	-1.9	-1.0
Body weight	0.6	2.5	4.1	1.7	-1.3	1.1	2.0
Epididymis fat weight	0.1	0.3	0.8	0.3	-0.3	-0.2	0.9
Glucose	0.0	0.0	0.1	0.2	-0.1	-0.1	0.2
Heart weight	0.3	0.4	0.7	0.6	-0.7	0.1	0.8
Left kidney weight	3.4	9.7	10.7	3.2	-3.1	2.9	3.3
Right kidney weight	1.3	3.6	4.0	2.0	-1.9	1.9	1.8
Tail length	0.2	0.7	1.1	-0.8	1.0	-0.5	-0.9
Length with tail	1.2	4.4	5.1	2.1	-1.9	2.3	2.1
Length without tail	4.8	10.5	11.3	3.3	-3.3	3.1	3.4
Liver weight, left	3.2	5.1	5.6	2.4	-2.2	2.1	2.3
Liver weight, right	1.0	1.7	2.1	1.5	-1.1	1.2	1.4
Parametrial fat weight	0.0	0.1	0.2	0.0	0.0	-0.1	0.5
Retroperitoneal fat weight	0.4	1.3	2.9	1.1	-0.9	0.8	1.7
Intraocular pressure	0.7	1.0	1.5	-1.2	1.0	-1.2	-0.2
Extensor digitorum longus weight	1.4	5.8	6.5	-2.4	2.5	-2.5	-2.2
Soleus weight	0.8	2.2	3.2	-1.2	1.8	-1.5	-1.4
Tibialis anterior weight	0.2	0.5	0.7	-0.6	0.7	-0.8	-0.8
Tibia length	13.4	37.9	41.3	6.4	-5.8	6.4	6.0
Number of licking bursts	0.0	0.0	0.0	0.2	0.2	0.2	0.2
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.1	0.4	0.3	-0.3
Times rat made contact with spout	0.3	0.3	0.5	-0.6	0.7	-0.4	-0.5
Mean time between licks in bursts	0.0	0.0	0.0	0.1	-0.2	0.1	-0.2
Mean num. licks in bursts	0.5	0.6	0.8	-0.9	0.6	-0.8	-0.8
Std. dev. time between licks in bursts	2.0	2.4	2.7	-1.6	1.6	-1.3	-1.6
Water consumed over 24 hours	0.3	0.4	0.9	-0.5	1.0	-0.3	-0.6
Indifference point 0 sec	1.0	1.7	2.4	-1.5	1.2	-1.4	-0.9
Indifference point AUC	2.5	2.9	3.8	-1.6	2.0	-1.3	-1.9
Indifference point function ln k	0.3	0.4	0.7	0.4	-0.9	0.0	0.8
Indifference point function log k	0.3	0.4	0.7	0.4	-0.9	0.0	0.8
Delay discounting total patch changes 0 sec	1.4	2.3	3.2	-1.8	1.4	-1.7	-1.2
Delay discounting total patch changes 12 sec	4.7	6.3	7.4	-2.5	2.7	-2.4	-2.3
Delay discounting total patch changes 18 sec	2.9	3.8	4.6	-2.1	2.2	-1.8	-1.6
Delay discounting total patch changes 24 sec	0.0	0.0	0.1	-0.1	0.0	0.3	0.1
Delay discounting total patch changes 6 sec	2.4	3.7	4.4	-1.9	2.1	-1.9	-1.8
Delay discounting time to switch 0 sec	0.3	0.4	0.6	0.8	-0.6	0.6	0.7
Delay discounting water rate 0 sec	0.8	1.2	1.6	-1.3	1.2	-1.0	-0.9
Delay discounting water rate 12 sec	0.2	0.3	0.8	-0.4	0.4	-0.9	0.2
Delay discounting water rate 18 sec	0.3	0.4	0.6	-0.7	0.4	-0.8	-0.4
Delay discounting water rate 24 sec	2.1	2.9	3.6	-1.8	1.8	-1.9	-1.2
Delay discounting water rate 6 sec	0.0	0.1	0.1	-0.2	0.2	-0.4	-0.1
Locomotor activity	0.0	0.0	0.1	-0.2	-0.2	-0.0	-0.2
Locomotor testing distance	0.1	0.1	0.3	-0.1	-0.6	-0.0	-0.0
Locomotor testing rearing	1.0	1.5	2.2	-1.4	0.9	-1.0	-1.5
Light reinforcement 1	2.3	4.3	5.4	-2.0	2.3	-2.0	-1.9
Light reinforcement 2	0.2	0.3	0.9	-0.3	0.9	-0.3	-0.4
Reaction time number correct	4.2	6.0	7.6	-2.5	2.8	-2.3	-2.2
Reaction time mean minus median	0.7	0.9	1.1	1.1	-0.9	0.9	0.9
Reaction time mean minus median AUC	1.0	1.3	1.7	1.3	-1.0	1.3	1.0
Reaction time num false alarms	0.1	0.1	0.2	-0.5	0.2	-0.4	-0.1
Reaction time num false alarms AUC	0.3	0.4	0.7	-0.8	0.4	-0.7	-0.4
Reaction time trials correct on left	4.2	6.0	7.6	-2.5	2.8	-2.3	-2.2
Reaction time trials on left	4.1	5.9	7.5	-2.5	2.7	-2.3	-2.2
Reaction time mean	0.1	0.1	0.2	0.3	-0.5	0.3	0.2
Reaction time mean AUC	0.0	0.0	0.1	0.1	-0.3	0.0	0.0
Median of all reaction times	0.0	0.1	0.2	0.1	-0.4	0.2	-0.1
Reaction time omissions	0.7	0.9	1.1	1.0	-0.8	1.1	1.0
Reaction time false alarm rate	0.4	0.5	1.0	0.5	-1.0	0.6	0.7
Reaction time premature initiation rate	2.7	3.6	4.5	-1.9	1.7	-2.1	-1.8
Reaction time premature initiations	6.2	8.9	10.1	-3.1	3.0	-3.2	-2.7
Std. dev. reaction times	0.1	0.1	0.2	0.4	-0.4	0.3	0.3
Reaction time trials completed	4.1	5.9	7.5	-2.5	2.7	-2.3	-2.2
Reaction time trials AUC	4.9	7.0	8.8	-2.7	3.0	-2.5	-2.4
Social response proportion	0.5	0.5	0.6	-0.7	0.8	-0.8	-0.5
Social responses	0.2	0.2	0.5	-0.3	0.7	-0.2	-0.5
Social time	0.5	0.7	0.8	-0.8	0.9	-0.9	-0.8
Conditioned locomotion	0.2	0.2	0.4	-0.6	0.6	-0.4	-0.3
Cocaine response after cond. corrected	0.3	0.3	0.8	0.5	-0.5	0.3	0.9
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.3	-0.3	0.3	0.4
Cocaine response before conditioning	0.3	0.3	1.0	-0.4	0.3	0.0	-1.0
Saline control response	0.3	0.4	0.8	-0.1	0.9	0.5	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	0.5	-0.7	0.8	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.4	-0.3	0.5	0.2
Condit. Reinf. active responses	0.0	0.0	0.1	-0.4	-0.0	-0.1	-0.2
Condit. Reinf. inactive responses	0.6	0.7	1.0	-1.0	0.7	-0.8	-0.8
Condit. Reinf. lever presses	1.1	1.5	2.0	-1.4	1.0	-1.1	-1.4
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	-0.6	0.1	-0.5	-0.3
Pavlov. Cond. lever latency	1.1	1.5	2.4	1.5	-0.9	1.2	1.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.7	0.3	-0.9	-0.2
Pavlov. Cond. change in total contacts	0.9	1.2	1.7	-1.3	0.8	-1.3	-1.0
Pavlov. Cond. index score	0.7	0.9	1.4	-1.2	0.6	-1.0	-0.8
Pavlov. Cond. latency score	0.4	0.5	0.9	-0.9	0.4	-0.8	-0.6
Pavlov. Cond. lever contacts	1.2	1.7	2.5	-1.6	1.0	-1.1	-1.4
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	1.1	-0.7	1.2	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	-0.5	0.4	0.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.6	-1.3	0.7	-1.1	-0.9
Pavlov. Cond. response bias	0.9	1.2	1.8	-1.3	0.8	-1.1	-1.0
Conditioned reinforcement - actives	0.9	0.9	1.2	-1.0	0.8	-1.1	-0.8
Conditioned reinforcement - inactives	0.3	0.3	0.4	0.6	-0.6	0.6	0.3
Conditioned locomotion	1.1	1.3	2.1	-1.3	0.9	-1.4	-0.9
Intermittent access intake day 1-15 change	0.2	0.2	0.5	0.5	-0.0	0.7	-0.2
Intermittent access intake escalation	0.1	0.1	0.2	0.2	0.2	0.5	-0.4
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.3	0.8	-0.1	-0.7
Intermitt. access day 1 inactive lever presses	2.4	2.6	3.0	1.6	-1.7	1.7	1.4
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.6	-0.6	0.8	-0.5	-0.8
Intermitt. access escalation Index	0.7	0.7	1.1	0.8	-0.7	1.0	0.7
Intermittent access day 1 total infusions	0.2	0.3	0.5	0.2	-0.7	-0.1	0.7
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.1	-0.2	0.1	0.1
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	0.4	-0.5	0.4	0.5
Intermittent access total infusions	0.2	0.2	0.4	0.3	-0.6	0.1	0.6
Intermittent access day 1 locomotion	0.5	0.5	1.1	-0.8	0.4	-1.1	-0.4
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.2	-0.5	0.0	0.4
Intermittent access total locomotion	0.2	0.3	0.6	-0.6	0.3	-0.8	-0.3
Intermittent access standard deviation	4.7	5.0	5.6	2.4	-2.2	2.1	2.2
Cocaine induced anxiety	0.4	0.5	1.0	0.8	-0.5	1.0	0.3
Post-drug Anxiety	0.1	0.1	0.2	-0.1	0.5	0.0	-0.3
Baseline Anxiety	0.0	0.0	0.1	-0.2	0.1	-0.3	0.1
Lifetime Intake	0.3	0.4	0.6	0.5	-0.7	0.3	0.8
Incentive Sensitization - Responses	0.7	0.7	1.0	0.8	-0.9	0.6	1.0
Incentive Sensitization - Breakpoint	1.0	1.0	1.2	1.0	-1.1	0.8	1.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.4	0.1	-0.4	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.3	0.0	-0.3	0.0
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.4	0.5	-0.7	0.7	0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.5	0.1	-0.6	-0.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.5	0.2	-0.6	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.1	-0.1	0.0	0.0
Total sessions with >9 infusions	1.2	1.3	1.8	1.1	-1.3	0.7	1.3
Short access day 1 total inactive lever presses	0.4	0.5	0.6	0.6	-0.8	0.5	0.7
Short access day 10 total inactive lever presses	1.0	1.1	1.8	1.2	-0.9	1.3	0.7
Short access day 1 total infusions	1.4	1.5	2.3	1.2	-1.2	1.0	1.5
Short access day 10 total infusions	1.7	1.9	2.9	1.2	-1.5	0.9	1.7
Short access total infusions	0.4	0.4	0.8	0.5	-0.6	0.2	0.9
Short access day 1 locomotion	0.4	0.5	0.6	0.7	-0.7	0.5	0.8
Short access day 10 total locomotion	0.5	0.5	0.7	0.7	-0.8	0.5	0.8
Short access total locomotion	1.2	1.2	1.6	1.1	-1.2	0.7	1.3
Compulsive drug intake	0.6	0.6	0.9	-0.7	0.8	-0.9	-0.5
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.5	0.3	-0.6	-0.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.0	-0.2	0.2	0.1
Number of responses in last shaping day	2.6	2.6	3.0	1.7	-1.7	1.6	1.5
Context. condit. distance diff. score	0.2	0.2	0.3	0.4	-0.6	0.3	0.6
Locomotion velocity, session 1	0.7	0.7	1.4	0.9	-0.6	1.2	0.5
Locomotion distance, session 1	2.5	3.3	3.6	-1.8	1.9	-1.8	-1.7
Locomotion velocity, session 2	0.6	0.7	0.9	-0.8	0.7	-0.7	-0.9
Locomotion distance, session 2	5.7	8.1	8.4	-2.9	2.8	-2.8	-2.9
Locomotion velocity, session 3	0.1	0.1	0.3	0.3	0.1	0.5	-0.1
Locomotion distance, session 3	0.2	0.2	0.4	-0.3	0.6	-0.6	-0.4
Stereotopy head waving bouts, day 3	2.2	2.7	3.3	1.6	-1.8	1.4	1.8
Stereotopy head waving duration, day 3	2.3	2.8	3.8	1.5	-1.9	1.5	1.8
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.2
Locomotion distance, session 7	3.3	4.2	4.7	-2.2	2.0	-2.2	-1.9
Stereotopy head waving bouts, day 7	4.2	4.8	5.4	2.2	-2.2	2.1	2.3
Stereotopy head waving duration, day 7	6.5	8.0	8.7	2.8	-3.0	2.9	2.6
Locomotion velocity, session 8	0.4	0.5	0.8	0.7	-0.8	0.9	0.4
Locomotion distance, session 8	2.7	4.0	4.9	-2.2	1.9	-2.2	-1.7
Degree of sensitization distance	3.5	3.5	4.6	-2.1	1.7	-1.8	-1.9
Degree of sensitization stereotypy	1.8	2.0	2.1	1.4	-1.4	1.4	1.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.5	-0.0	-0.3	-0.6
Condit. Reinf. active responses	0.7	0.8	1.1	-0.9	1.1	-0.7	-0.9
Condit. Reinf. inactive responses	1.0	1.2	2.3	-1.0	1.5	-0.9	-0.8
Incentive salience index mean	0.0	0.0	0.1	-0.2	0.2	0.0	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.2	0.2	-0.2	-0.3
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.7	-0.5	0.7	0.5
Total zone transitions, hab. session 1	2.2	3.1	3.9	-1.8	1.7	-1.6	-2.0
Total locomotion distance, hab. session 1	1.8	2.5	2.8	-1.7	1.6	-1.6	-1.5
Locomotion velocity, hab. session 1	2.4	3.4	3.7	-1.9	1.9	-1.9	-1.7
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.3	0.3	-0.4	0.1
Time in novel zone, hab. session 2	0.4	0.4	0.6	0.7	-0.8	0.7	0.4
Total zone transitions, hab. session 2	6.6	8.5	9.3	-3.1	2.8	-3.0	-2.9
Total locomotion distance, hab. session 2	6.3	8.3	9.5	-3.0	3.0	-3.1	-2.5
Locomotion velocity, hab. session 2	6.3	8.5	9.3	-3.0	3.1	-3.0	-2.5
Novel to familiar place preference ratio	2.1	2.2	2.9	-1.7	1.2	-1.7	-1.4
Novelty place preference	1.6	1.7	2.2	-1.5	1.0	-1.4	-1.2
Time in novel zone, NPP test	2.0	2.1	2.6	-1.6	1.2	-1.6	-1.4
Total zone transitions, NPP test	4.7	6.8	7.4	-2.7	2.7	-2.5	-2.5
Total locomotion distance, NPP test	8.0	11.1	12.5	-3.4	3.5	-3.5	-2.9
Locomotion velocity, NPP test	6.8	9.7	10.8	-3.2	3.3	-3.3	-2.7
Pavlov. Cond. lever latency	0.5	0.7	1.0	-0.9	0.7	-1.0	-0.6
Pavlov. Cond. magazine entry latency	2.3	3.0	4.1	1.8	-1.7	2.0	1.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.3	0.1	-0.4	-0.6
Pavlov. Cond. index score	1.5	1.9	2.4	1.4	-1.3	1.6	1.2
Pavlov. Cond. latency score	2.0	2.5	3.2	1.7	-1.5	1.8	1.4
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	-0.2	0.4	0.2
Pavlov. Cond. magazine entry number	3.3	4.2	4.7	-2.1	2.1	-2.2	-1.8
Pavlov. Cond. intertrial magazine entries	2.4	2.8	3.0	-1.7	1.6	-1.7	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.8	1.2	-1.1	1.3	0.9
Pavlov. Cond. response bias	1.5	1.9	2.2	1.4	-1.4	1.5	1.1
Bone: apparent density	1.0	1.6	2.5	-1.4	0.8	-1.2	-1.6
Bone surface	0.4	0.6	1.2	0.5	-1.1	1.0	0.4
Bone volume	0.1	0.1	0.1	-0.3	-0.4	0.1	-0.3
Bone: connectivity density	1.5	2.3	4.0	-1.5	1.2	-1.2	-2.0
Bone: cortical apparent density	1.3	1.7	2.4	-1.1	1.1	-1.5	-1.4
Bone: cortical area	3.3	5.0	6.1	2.3	-2.5	2.1	2.1
Bone: cortical porosity	2.3	2.5	3.2	1.6	-1.8	1.8	1.1
Bone: cortical porosity	3.2	3.4	4.2	1.8	-2.1	2.0	1.4
Bone: cortical thickness	0.3	0.5	1.2	1.1	-0.7	0.5	0.5
Bone: cortical thickness	0.2	0.2	0.5	0.7	-0.4	0.4	0.3
Bone: cortical tissue density	1.4	1.8	2.5	-1.2	1.1	-1.6	-1.4
Bone: elastic displacement	0.9	1.0	1.3	-0.9	0.9	-1.1	-1.2
Bone: elastic work	0.3	0.4	0.6	0.8	-0.8	0.4	0.5
Bone: endosteal estimation	0.8	1.8	2.8	0.6	-1.7	1.1	1.6
Bone: endosteal perimeter	4.2	8.7	11.0	2.5	-3.3	3.0	2.9
Bone: final force	1.3	2.2	2.6	1.6	-1.6	1.3	1.3
Bone: final moment	1.4	2.4	2.9	1.7	-1.7	1.4	1.3
Bone: marrow area	0.9	1.8	2.9	0.7	-1.7	1.2	1.6
Bone: maximum diameter	7.6	14.0	17.3	3.5	-4.2	3.7	3.6
Bone: maximum force	1.3	2.3	3.1	1.6	-1.8	1.2	1.5
Bone: maximum moment	1.4	2.5	3.5	1.6	-1.9	1.2	1.5
Bone: minimum diameter	2.8	5.3	7.9	1.9	-2.8	2.4	1.9
Bone: periosteal estimation	2.7	5.6	7.7	2.0	-2.8	2.2	2.5
Bone: periosteal perimeter	6.6	10.9	12.7	3.2	-3.6	3.3	3.2
Bone: post-yield work	0.5	0.7	1.1	-0.9	0.5	-1.0	-0.8
Bone: stiffness	1.6	2.6	3.1	1.7	-1.8	1.5	1.4
Bone: tissue strength	0.7	0.6	1.3	-0.8	0.4	-1.1	-0.7
Bone: trabecular number	0.4	0.6	1.1	-0.7	0.6	-0.5	-1.1
Bone: trabecular spacing	0.4	0.5	1.2	0.5	-0.5	0.4	1.1
Bone: trabecular thickness	0.5	0.6	1.2	-0.8	0.4	-0.6	-1.1
Bone: trabecular tissue density	0.1	0.2	0.4	0.3	-0.1	0.4	0.7
Breakpoint value in progressive ratio session	0.2	0.2	0.6	-0.1	-0.3	-0.4	0.8
Distance traveled before self-admin	1.2	1.3	1.7	1.2	-1.1	1.3	0.9
Distance traveled after self-admin	1.5	1.6	2.2	-1.5	1.1	-1.4	-1.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.5	-0.4	0.5	0.7
Delta time in open arm before/after self-admin	1.4	1.3	2.1	-1.1	1.1	-0.8	-1.5
Diff in mean of infusions in LGA sessions	0.6	0.7	1.5	0.5	-0.9	0.3	1.2
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.1	-0.1	0.0	0.1
Active lever presses in extinction session 6	0.3	0.2	0.5	-0.4	0.5	-0.7	0.2
Delta distance traveled before/after self-admin	3.5	3.7	4.2	-2.0	1.8	-2.0	-1.8
Delta ambulatory time before/after self-admin	4.0	4.3	4.8	-2.2	2.0	-2.2	-1.9
Time in closed arm before self-admin	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1
Time in closed arm after self-admin	2.5	2.6	3.1	1.6	-1.7	1.4	1.8
Time in open arm before self-admin	0.4	0.4	0.5	0.7	-0.5	0.6	0.7
Time in open arm after self-admin	0.7	0.8	1.0	-0.9	1.0	-0.7	-1.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.3	-0.7	0.3	0.5
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.2	-0.7	0.9	-0.4	-1.1
Time to tail flick, vehicle, after self-admin	1.4	1.5	1.9	1.4	-1.2	0.8	1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.6	0.4	-0.2	-0.5
Time to tail flick, test, after self-admin	0.9	0.9	1.3	0.9	-0.8	0.9	1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.3	-0.5	-0.1	0.7
Delta time to tail flick, test, before/after SA	1.6	1.4	1.9	1.4	-1.0	0.9	1.4
Ambulatory time before self-admin	2.0	2.1	2.7	1.5	-1.4	1.6	1.3
Ambulatory time after self-admin	0.5	0.5	0.7	-0.8	0.6	-0.8	-0.6
Total heroin consumption	3.0	3.6	4.4	1.8	-2.1	1.7	2.0
Area under the delay curve	1.2	1.3	2.0	1.1	-1.1	1.4	0.9
Delay disc. indifference point, 0s delay	1.5	1.7	2.6	1.3	-1.3	1.6	0.8
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	-0.6	0.6	-0.6	-0.5
Delay disc. indifference point, 2s delay	0.5	0.6	0.9	0.6	-0.8	1.0	0.6
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.3
Delay disc. indifference point, 4s delay	1.4	1.4	2.3	1.2	-1.1	1.5	0.8
Delay disc. indifference point, 8s delay	4.1	4.3	5.9	2.1	-1.9	2.4	1.8
Delay discount exponential model param	1.6	1.7	2.5	-1.2	1.2	-1.6	-1.1
Delay discount hyperbolic model param	1.4	1.5	2.3	-1.2	1.2	-1.5	-1.0
Fecal boli incidents, locomotor time 1	0.4	0.4	0.8	-0.8	0.3	-0.9	-0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	0.1	-0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.1	-0.2	0.4	-0.1
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.0	-0.1	-0.1	0.1
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.1	0.0	-0.2	-0.1
Rest time, locomotor task time 1	0.3	0.3	0.7	0.5	-0.6	0.1	0.8
Distance moved, locomotor task time 1	0.3	0.3	0.5	-0.5	0.7	-0.1	-0.7
Vertical activity count, locomotor time 1	1.6	1.7	2.4	-1.3	1.5	-1.0	-1.3
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.6	-0.4	0.6	-0.4	-0.8
Bouts of movement, locomotor time 2	0.2	0.2	0.4	0.4	-0.6	0.2	0.6
Total resting periods, locomotor time 2	0.2	0.3	0.4	0.4	-0.7	0.2	0.6
Rest time, locomotor task time 2	0.8	0.9	1.8	0.6	-1.2	0.4	1.3
Distance moved, locomotor task time 2	0.2	0.2	0.5	-0.2	0.6	-0.1	-0.7
Vertical activity count, locomotor time 2	0.2	0.2	0.3	-0.4	0.6	-0.4	-0.2
Weight adjusted by age	0.0	0.0	0.1	0.1	-0.3	0.0	0.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.7	-0.3	0.3	-0.1	-0.9
Locomotion in novel chamber	0.6	0.8	1.1	-0.9	0.9	-0.5	-1.0
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.2	-0.4	0.3	0.3
Progressive ratio	0.1	0.1	0.3	-0.1	-0.4	-0.4	0.5
Food seeking constrained by brief footshock	0.8	1.0	1.4	0.9	-1.1	0.7	1.2
Seeking ratio, punishment vs. effort	0.3	0.3	0.7	0.6	-0.4	0.8	0.2
Run reversals in cocaine runway, females	0.1	0.1	0.4	0.2	-0.2	0.2	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.2	-0.1	-0.2	0.5
Latency to leave start box in cocaine runway	0.3	0.3	0.7	-0.6	0.3	-0.8	-0.3
Latency to leave start box in cocaine runway, F	0.6	0.6	0.9	-0.8	0.9	-0.9	-0.6
Latency to leave start box in cocaine runway, M	0.6	0.6	1.0	-0.9	0.5	-1.0	-0.6
Cd content in liver	0.7	0.8	1.0	-0.8	0.8	-1.0	-0.9
Co content in liver	0.4	0.5	0.7	-0.8	0.6	-0.9	-0.6
Cu content in liver	0.0	0.1	0.1	0.1	-0.1	0.2	0.4
Fe content in liver	0.1	0.1	0.2	0.1	-0.3	0.4	0.4
K content in liver	0.0	0.0	0.1	-0.1	0.0	0.2	-0.4
Mg content in liver	1.9	2.0	2.6	-1.4	1.2	-1.3	-1.6
Mn content in liver	0.7	0.8	1.1	1.1	-0.6	1.1	0.8
Na content in liver	0.4	0.4	0.9	0.6	-0.7	0.9	0.1
Rb content in liver	3.1	3.8	4.0	-1.9	2.0	-2.0	-2.0
Se content in liver	0.4	0.5	0.8	-0.7	0.9	-0.3	-0.8
Sr content in liver	0.1	0.1	0.1	0.4	-0.2	0.2	0.3
Zn content in liver	1.8	1.9	2.5	1.4	-1.6	1.4	1.2