Hub : Genes

Bahcc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000043102	0.03	0.03	5.5e-04	0.03	0.03	0.02	0.03	4.2e-04	9.4e-05	1.6e-03	1.3e-04
2	Liver	gene expression	ENSRNOG00000043102	0.04	0.03	2.6e-04	0.02	0.03	0.01	0.03	9.2e-04	2.6e-04	3.2e-02	4.8e-04
3	Liver	mRNA stability	ENSRNOG00000043102	0.77	0.2	0.0e+00	0.55	0.55	0.55	0.55	3.8e-73	3.1e-72	1.4e-73	3.5e-73

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	0.0	0.0	0.0	0.1	0.0	-0.1
BMI without tail	0.1	0.1	0.2	0.4	-0.1	0.4
Body weight	2.3	9.5	10.1	3.2	-2.9	3.2
Epididymis fat weight	0.1	0.3	0.4	0.6	-0.5	0.6
Glucose	0.0	0.0	0.1	-0.0	-0.2	-0.3
Heart weight	0.1	0.2	0.2	0.5	-0.4	0.2
Left kidney weight	0.6	1.7	1.8	1.3	-1.3	1.3
Right kidney weight	0.1	0.3	0.4	0.6	-0.7	0.4
Tail length	2.1	6.3	7.2	2.6	-2.3	2.7
Length with tail	3.2	11.8	12.1	3.5	-3.4	3.5
Length without tail	1.6	3.6	4.1	1.9	-2.0	1.8
Liver weight, left	0.3	0.4	0.6	0.7	-0.8	0.4
Liver weight, right	3.3	5.4	6.9	2.2	-2.1	2.6
Parametrial fat weight	1.1	2.1	2.6	1.6	-1.5	1.1
Retroperitoneal fat weight	2.0	6.6	7.8	2.8	-2.5	2.4
Intraocular pressure	0.0	0.0	0.0	0.1	-0.1	0.0
Extensor digitorum longus weight	0.5	2.0	2.2	-1.3	1.5	-1.4
Soleus weight	0.8	2.4	2.5	1.6	-1.5	1.6
Tibialis anterior weight	0.0	0.2	0.2	-0.4	0.5	-0.2
Tibia length	10.5	29.7	32.9	5.7	-5.6	5.0
Number of licking bursts	0.0	0.0	0.0	0.1	-0.0	0.0
Food consumed during 24 hour testing period	0.2	0.3	0.6	0.4	-0.3	0.7
Times rat made contact with spout	3.0	3.4	3.6	1.8	-1.8	1.9
Mean time between licks in bursts	1.2	1.7	1.8	-1.4	1.3	-1.3
Mean num. licks in bursts	0.6	0.8	0.8	0.8	-0.9	0.9
Std. dev. time between licks in bursts	1.1	1.3	1.6	-1.1	1.3	-1.1
Water consumed over 24 hours	0.6	0.7	0.9	0.7	-0.8	1.0
Indifference point 0 sec	0.0	0.0	0.0	0.2	-0.2	0.1
Indifference point AUC	0.1	0.2	0.3	-0.3	0.3	-0.6
Indifference point function ln k	0.7	1.0	1.2	-1.1	1.1	-0.8
Indifference point function log k	0.7	1.0	1.2	-1.1	1.1	-0.8
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	-0.0	0.1	-0.1
Delay discounting total patch changes 12 sec	0.0	0.0	0.1	0.2	-0.3	0.0
Delay discounting total patch changes 18 sec	1.2	1.5	2.1	-1.1	1.2	-1.4
Delay discounting total patch changes 24 sec	0.1	0.1	0.2	0.4	-0.4	0.2
Delay discounting total patch changes 6 sec	0.6	1.0	1.1	1.0	-1.0	0.9
Delay discounting time to switch 0 sec	0.1	0.2	0.2	-0.4	0.4	-0.4
Delay discounting water rate 0 sec	0.3	0.5	0.6	0.7	-0.5	0.8
Delay discounting water rate 12 sec	0.4	0.7	0.8	-0.8	0.9	-0.7
Delay discounting water rate 18 sec	0.1	0.1	0.2	-0.3	0.4	0.2
Delay discounting water rate 24 sec	0.2	0.3	0.5	-0.5	0.7	-0.5
Delay discounting water rate 6 sec	0.1	0.1	0.2	-0.4	0.5	0.2
Locomotor activity	0.3	0.4	0.6	-0.7	0.7	-0.4
Locomotor testing distance	0.8	1.3	1.5	-1.2	1.2	-0.9
Locomotor testing rearing	0.6	0.9	1.1	-1.0	1.1	-0.8
Light reinforcement 1	0.0	0.0	0.0	0.1	0.1	-0.1
Light reinforcement 2	1.0	1.3	1.9	1.0	-0.9	1.4
Reaction time number correct	4.2	6.0	6.4	-2.3	2.5	-2.5
Reaction time mean minus median	0.3	0.4	0.4	0.6	-0.7	0.6
Reaction time mean minus median AUC	0.3	0.3	0.4	0.6	-0.6	0.5
Reaction time num false alarms	0.2	0.3	0.4	-0.5	0.5	-0.6
Reaction time num false alarms AUC	0.6	0.9	0.9	-0.9	0.9	-1.0
Reaction time trials correct on left	4.2	6.0	6.4	-2.3	2.5	-2.5
Reaction time trials on left	4.3	6.1	6.6	-2.4	2.6	-2.5
Reaction time mean	0.0	0.0	0.0	0.1	-0.1	-0.2
Reaction time mean AUC	0.1	0.1	0.3	-0.1	0.2	-0.5
Median of all reaction times	0.1	0.1	0.3	-0.1	0.2	-0.5
Reaction time omissions	0.0	0.0	0.0	-0.1	0.1	0.1
Reaction time false alarm rate	0.1	0.2	0.2	0.3	-0.5	0.4
Reaction time premature initiation rate	0.8	1.1	1.3	-1.2	1.1	-0.8
Reaction time premature initiations	3.5	5.0	5.3	-2.3	2.3	-2.1
Std. dev. reaction times	0.3	0.4	0.5	-0.6	0.6	-0.7
Reaction time trials completed	4.3	6.1	6.6	-2.4	2.6	-2.5
Reaction time trials AUC	4.1	5.9	6.3	-2.3	2.5	-2.5
Social response proportion	0.7	0.8	0.9	-0.9	1.0	-0.7
Social responses	0.1	0.1	0.2	-0.5	0.5	-0.0
Social time	0.3	0.4	0.4	-0.6	0.7	-0.7
Conditioned locomotion	0.6	0.7	1.0	1.0	-0.8	0.6
Cocaine response after cond. corrected	0.0	0.1	0.2	0.0	-0.1	-0.4
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.4	0.3	-0.6
Cocaine response before conditioning	0.5	0.6	0.8	-0.9	0.9	-0.3
Saline control response	2.0	2.6	2.8	1.7	-1.6	1.6
Condit. Reinf. active minus inactive responses	0.4	0.5	0.6	0.7	-0.6	0.8
Condit. Reinf. active-inactive response ratio	2.4	2.6	2.7	1.6	-1.6	1.6
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.3	-0.1
Condit. Reinf. inactive responses	1.4	1.7	1.7	-1.3	1.3	-1.3
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.6	0.7	-0.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	-0.5	0.6	-0.6
Pavlov. Cond. lever latency	0.3	0.4	0.5	0.5	-0.6	0.7
Pavlov. Cond. magazine entry latency	4.3	5.0	5.1	-2.2	2.3	-2.2
Pavlov. Cond. change in total contacts	1.9	2.6	3.1	-1.5	1.6	-1.8
Pavlov. Cond. index score	1.8	2.3	2.7	-1.4	1.5	-1.7
Pavlov. Cond. latency score	1.7	2.2	2.4	-1.4	1.5	-1.5
Pavlov. Cond. lever contacts	0.3	0.4	0.6	-0.5	0.6	-0.7
Pavlov. Cond. magazine entry number	3.8	4.7	4.8	2.1	-2.2	2.2
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.3	1.1	-1.1	0.9
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	3.2	-1.6	1.7	-1.8
Pavlov. Cond. response bias	1.0	1.4	1.7	-1.1	1.2	-1.3
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.2	0.2	-0.2
Conditioned reinforcement - inactives	1.5	1.7	2.2	1.2	-1.2	1.5
Conditioned locomotion	0.2	0.2	0.4	0.4	-0.4	0.6
Intermittent access intake day 1-15 change	0.5	0.5	0.6	0.8	-0.7	0.5
Intermittent access intake escalation	0.3	0.3	0.4	0.6	-0.5	0.4
Intermittent access intake escalation 2	3.3	3.3	4.1	1.7	-1.7	2.0
Intermitt. access day 1 inactive lever presses	1.3	1.4	1.6	1.2	-1.1	1.2
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.9	0.5	-0.3	0.9
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	-0.0	0.2
Intermittent access day 1 total infusions	0.1	0.1	0.1	0.3	-0.3	-0.0
Intermittent access day 15 total infusions	0.2	0.2	0.3	0.5	-0.5	0.1
Intermittent access terminal intake (last 3 days)	0.8	0.8	1.1	1.0	-1.0	0.7
Intermittent access total infusions	0.1	0.2	0.2	0.5	-0.4	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.3	-0.2	0.3
Intermittent access day 15 total locomotion	0.7	0.7	0.8	0.9	-0.9	0.7
Intermittent access total locomotion	0.4	0.4	0.5	0.7	-0.6	0.7
Intermittent access standard deviation	0.3	0.4	0.5	0.5	-0.6	0.7
Cocaine induced anxiety	6.8	7.8	8.8	2.7	-2.7	3.0
Post-drug Anxiety	1.2	1.3	2.1	1.0	-1.0	1.5
Baseline Anxiety	6.8	7.2	7.7	-2.8	2.7	-2.6
Lifetime Intake	0.0	0.1	0.1	0.3	-0.3	0.1
Incentive Sensitization - Responses	0.1	0.1	0.2	0.4	-0.4	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.4	-0.4	-0.2
Progressive ratio test 1 active lever presses	0.4	0.5	0.5	0.7	-0.6	0.7
Progressive ratio test 1 breakpoint	0.5	0.5	0.6	0.8	-0.7	0.7
Progressive ratio test 1 inactive lever presses	0.7	0.8	1.0	1.0	-0.9	0.8
Progressive ratio test 2 active lever presses	0.3	0.4	0.5	0.7	-0.7	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.5	-0.5	0.3
Progressive ratio test 2 inactive lever presses	0.6	0.6	0.7	0.8	-0.8	0.8
Total sessions with >9 infusions	0.1	0.1	0.1	-0.3	0.3	-0.4
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.4	0.4	-0.2
Short access day 10 total inactive lever presses	2.5	2.7	3.0	1.7	-1.6	1.6
Short access day 1 total infusions	0.6	0.7	0.8	-0.9	0.8	-0.7
Short access day 10 total infusions	0.6	0.7	0.7	0.8	-0.8	0.9
Short access total infusions	0.0	0.0	0.0	0.0	-0.0	-0.1
Short access day 1 locomotion	0.1	0.1	0.1	0.2	-0.3	0.3
Short access day 10 total locomotion	0.5	0.6	0.8	0.6	-0.7	0.9
Short access total locomotion	0.1	0.1	0.1	0.3	-0.4	0.3
Compulsive drug intake	0.0	0.0	0.0	0.1	-0.0	0.0
One hour access (0.3 mA shock)	0.3	0.3	0.4	0.6	-0.6	0.4
One hour access (shock baseline)	0.1	0.1	0.1	0.3	-0.3	0.2
Number of responses in last shaping day	0.8	0.8	1.0	0.9	-0.8	1.0
Context. condit. distance diff. score	0.6	0.8	1.2	-0.9	1.1	-0.6
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	0.2	-0.2
Locomotion distance, session 1	3.5	4.6	4.8	-2.2	2.2	-2.0
Locomotion velocity, session 2	1.4	1.6	2.2	-1.5	1.3	-1.0
Locomotion distance, session 2	1.1	1.5	1.8	-1.3	1.3	-1.0
Locomotion velocity, session 3	0.3	0.4	0.4	-0.6	0.5	-0.7
Locomotion distance, session 3	1.8	1.9	2.3	-1.5	1.4	-1.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.1	0.0	-0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.2	0.2	-0.2
Locomotion velocity, session 7	0.6	0.7	0.9	-0.9	0.9	-0.6
Locomotion distance, session 7	5.6	7.2	7.5	-2.7	2.7	-2.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.2	-0.2	0.6
Stereotopy head waving duration, day 7	0.8	1.0	1.7	0.8	-0.8	1.3
Locomotion velocity, session 8	1.7	2.0	2.5	-1.6	1.6	-1.1
Locomotion distance, session 8	2.4	3.5	4.5	-1.9	2.1	-1.5
Degree of sensitization distance	0.1	0.1	0.2	-0.3	0.4	-0.4
Degree of sensitization stereotypy	0.2	0.2	0.5	0.3	-0.2	0.7
Condit. Reinf. active minus inactive responses	1.0	1.1	1.5	1.0	-0.9	1.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.6	-0.5	0.6
Condit. Reinf. active responses	1.8	2.2	2.7	1.5	-1.3	1.6
Condit. Reinf. inactive responses	0.5	0.6	0.9	0.7	-0.6	0.9
Incentive salience index mean	1.0	1.2	1.8	1.0	-0.9	1.4
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.3	0.4	0.2
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.0	-0.0	-0.3
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.1	0.1	0.1
Total zone transitions, hab. session 1	0.9	1.2	1.3	-1.1	1.1	-1.1
Total locomotion distance, hab. session 1	0.3	0.4	0.5	-0.6	0.7	-0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.4	-0.6	0.7	-0.4
Time in familiar zone, hab. session 2	0.7	0.8	0.8	-0.9	0.9	-0.9
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.0	-0.1	0.0
Total zone transitions, hab. session 2	2.1	2.8	3.2	-1.7	1.8	-1.5
Total locomotion distance, hab. session 2	0.6	0.8	1.2	-1.0	1.1	-0.5
Locomotion velocity, hab. session 2	0.3	0.4	0.7	-0.7	0.8	-0.3
Novel to familiar place preference ratio	3.4	3.5	3.7	1.9	-1.8	1.9
Novelty place preference	3.4	3.6	3.7	1.9	-1.8	1.9
Time in novel zone, NPP test	2.4	2.5	2.6	1.6	-1.6	1.6
Total zone transitions, NPP test	2.9	4.2	4.7	-2.1	2.2	-1.9
Total locomotion distance, NPP test	1.8	2.4	3.1	-1.6	1.8	-1.2
Locomotion velocity, NPP test	0.9	1.3	1.8	-1.2	1.3	-0.9
Pavlov. Cond. lever latency	5.2	6.6	8.1	-2.4	2.4	-2.8
Pavlov. Cond. magazine entry latency	4.7	6.1	6.1	2.5	-2.5	2.4
Pavlov. Cond. change in total contacts	1.7	1.8	1.9	1.3	-1.4	1.4
Pavlov. Cond. index score	6.1	7.9	9.0	2.7	-2.7	3.0
Pavlov. Cond. latency score	6.5	8.3	9.7	2.7	-2.8	3.1
Pavlov. Cond. lever contacts	3.0	3.6	4.7	1.7	-1.7	2.2
Pavlov. Cond. magazine entry number	5.2	6.6	6.9	-2.6	2.6	-2.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.5	0.6	-0.8
Pavlov. Cond. lever-magazine prob. diff.	6.0	7.5	8.2	2.7	-2.7	2.9
Pavlov. Cond. response bias	5.2	6.3	6.4	2.5	-2.5	2.5
Bone: apparent density	0.0	0.0	0.0	0.0	0.1	-0.1
Bone surface	0.4	0.6	0.7	0.8	-0.8	0.8
Bone volume	0.1	0.2	0.2	0.5	-0.4	0.5
Bone: connectivity density	0.2	0.3	0.4	-0.6	0.6	-0.3
Bone: cortical apparent density	1.6	2.1	2.8	-1.4	1.3	-1.7
Bone: cortical area	6.1	9.2	9.6	3.1	-3.0	3.0
Bone: cortical porosity	4.2	4.6	5.1	2.2	-2.3	1.9
Bone: cortical porosity	3.6	3.9	4.3	2.0	-2.1	1.8
Bone: cortical thickness	6.5	10.8	11.5	3.4	-3.3	3.1
Bone: cortical thickness	1.5	1.8	2.2	1.5	-1.4	1.1
Bone: cortical tissue density	1.8	2.4	3.1	-1.5	1.4	-1.8
Bone: elastic displacement	1.5	1.7	2.1	1.4	-1.4	1.0
Bone: elastic work	9.4	12.2	13.9	3.7	-3.7	3.1
Bone: endosteal estimation	0.4	0.8	0.9	-0.9	0.9	-0.9
Bone: endosteal perimeter	0.7	1.4	1.6	1.2	-1.2	1.3
Bone: final force	4.2	6.9	7.3	2.7	-2.6	2.6
Bone: final moment	5.1	8.5	9.1	3.0	-2.9	2.8
Bone: marrow area	0.4	0.8	0.9	-0.9	0.9	-0.9
Bone: maximum diameter	1.9	3.4	4.1	1.8	-1.7	2.0
Bone: maximum force	3.7	6.4	6.9	2.6	-2.5	2.5
Bone: maximum moment	4.5	7.8	8.6	2.9	-2.8	2.7
Bone: minimum diameter	3.3	6.1	6.7	2.5	-2.4	2.6
Bone: periosteal estimation	1.1	2.2	2.4	1.6	-1.4	1.5
Bone: periosteal perimeter	5.5	9.1	9.3	3.1	-3.0	3.0
Bone: post-yield work	0.4	0.5	0.5	-0.7	0.7	-0.7
Bone: stiffness	0.4	0.6	0.7	0.8	-0.7	0.8
Bone: tissue strength	0.2	0.1	0.2	0.4	-0.3	0.4
Bone: trabecular number	0.0	0.0	0.0	0.0	-0.0	0.1
Bone: trabecular spacing	1.5	2.0	2.4	-1.4	1.5	-1.3
Bone: trabecular thickness	2.1	2.6	3.0	1.7	-1.7	1.4
Bone: trabecular tissue density	0.5	0.7	0.7	-0.8	0.8	-0.9
Breakpoint value in progressive ratio session	0.7	0.8	1.3	0.8	-0.8	1.1
Distance traveled before self-admin	2.3	2.4	3.4	1.4	-1.4	1.8
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	0.2	0.1
Delta time in closed arm before/after self-admin	0.1	0.0	0.1	0.2	-0.2	0.3
Delta time in open arm before/after self-admin	0.3	0.3	0.3	-0.5	0.6	-0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.1	0.1	0.5
Extinction: sum of active levers before priming	0.4	0.4	0.5	-0.7	0.6	-0.5
Active lever presses in extinction session 6	0.3	0.3	0.6	0.3	-0.3	0.8
Delta distance traveled before/after self-admin	2.1	2.2	2.7	-1.4	1.4	-1.6
Delta ambulatory time before/after self-admin	2.9	3.2	3.7	-1.7	1.7	-1.9
Time in closed arm before self-admin	0.0	0.0	0.0	0.1	-0.2	-0.2
Time in closed arm after self-admin	0.3	0.3	0.5	0.6	-0.7	0.4
Time in open arm before self-admin	0.1	0.1	0.2	-0.0	0.0	0.5
Time in open arm after self-admin	0.4	0.5	0.6	-0.7	0.8	-0.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.0	0.5	-0.5	1.0
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	0.1	-0.1	0.1
Time to tail flick, vehicle, after self-admin	0.9	1.0	1.2	-1.1	1.0	-0.9
Time to tail flick, test, before self-admin	0.3	0.3	0.4	0.5	-0.5	0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.1	0.1	0.5
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.6	-0.8	0.8	-0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.3	0.2	-0.2
Ambulatory time before self-admin	3.2	3.4	4.7	1.7	-1.6	2.2
Ambulatory time after self-admin	0.0	0.0	0.1	0.0	0.1	0.4
Total heroin consumption	0.7	0.9	1.7	0.7	-0.7	1.3
Area under the delay curve	1.6	1.7	2.2	-1.2	1.1	-1.5
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.1	0.1	-0.4
Delay disc. indifference point, 16s delay	4.4	4.5	4.9	-2.1	2.1	-2.2
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	-0.3	0.2	-0.1
Delay disc. indifference point, 24s delay	1.8	1.7	1.9	-1.4	1.2	-1.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.4	0.3	-0.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.3	0.2	-0.5
Delay discount exponential model param	1.6	1.7	2.3	1.2	-1.1	1.5
Delay discount hyperbolic model param	1.5	1.6	2.1	1.2	-1.1	1.5
Fecal boli incidents, locomotor time 1	0.6	0.6	0.7	-0.8	0.8	-0.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.3	0.1	-0.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	-0.5	0.5	-0.7
Bouts of movement, locomotor time 1	1.1	1.2	1.4	-1.1	1.0	-1.2
Total resting periods, locomotor time 1	0.8	0.9	1.1	-1.0	0.9	-1.1
Rest time, locomotor task time 1	0.1	0.1	0.1	0.3	-0.4	0.2
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.2	-0.1	-0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.0	0.1	-0.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	-0.2	-0.1
Bouts of movement, locomotor time 2	1.5	1.6	1.8	-1.3	1.2	-1.4
Total resting periods, locomotor time 2	1.4	1.5	1.6	-1.2	1.2	-1.2
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.0	-0.0	-0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.1	-0.1	-0.3
Vertical activity count, locomotor time 2	0.2	0.3	0.3	-0.5	0.5	-0.6
Weight adjusted by age	2.3	2.6	2.9	1.6	-1.5	1.7
Seeking ratio, delayed vs. immediate footshock	1.0	1.1	1.3	1.0	-1.0	1.1
Locomotion in novel chamber	0.5	0.7	0.7	-0.8	0.8	-0.8
Locomotion in novel chamber post-restriction	1.4	1.6	2.0	1.4	-1.3	1.1
Progressive ratio	0.2	0.2	0.3	-0.5	0.5	-0.2
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.1	-0.1	0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	-0.1	-0.2
Run reversals in cocaine runway, females	3.2	3.1	4.2	-1.6	1.6	-2.0
Run reversals in cocaine runway, males	3.3	3.2	3.4	1.7	-1.7	1.9
Latency to leave start box in cocaine runway	0.6	0.7	0.9	-0.7	0.7	-1.0
Latency to leave start box in cocaine runway, F	1.1	1.2	1.3	-1.1	1.1	-1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	-0.3	0.0
Cd content in liver	2.6	2.9	2.9	-1.7	1.7	-1.7
Co content in liver	0.2	0.3	0.4	-0.5	0.5	-0.6
Cu content in liver	1.9	2.3	2.4	1.5	-1.5	1.5
Fe content in liver	1.0	1.2	1.4	-1.1	1.0	-1.2
K content in liver	0.7	0.7	0.9	0.8	-0.7	1.0
Mg content in liver	0.4	0.4	0.6	-0.7	0.8	-0.5
Mn content in liver	0.7	0.8	1.3	0.7	-0.7	1.1
Na content in liver	0.2	0.2	0.3	0.3	-0.3	0.5
Rb content in liver	0.0	0.0	0.0	-0.0	0.1	0.1
Se content in liver	0.1	0.1	0.2	0.3	-0.2	0.4
Sr content in liver	0.8	0.8	0.9	0.9	-1.0	0.8
Zn content in liver	0.4	0.4	0.5	0.6	-0.7	0.7