Hub : Genes

Cenpk

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression ENSRNOG00000039740 0.04 0.05 6.8e-03 0.02 0.01 0.03 0.03 8.9e-03 9.6e-02 4.6e-03 4.8e-03
2 NAcc isoform ratio ENSRNOT00000103473 0.05 0.05 3.4e-03 0.02 0.01 0.02 0.01 6.7e-03 4.4e-02 9.6e-03 7.6e-02
3 OFC isoform ratio ENSRNOT00000103473 0.12 0.11 9.5e-03 0.03 0.07 0.05 -0 5.9e-02 9.4e-03 2.4e-02 4.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail1.86.07.22.7-2.3-2.3
BMI without tail0.30.60.90.9-0.7-0.7
Body weight1.77.27.8-2.52.72.8
Epididymis fat weight0.00.00.1-0.3-0.1-0.1
Glucose0.50.81.50.5-0.8-1.2
Heart weight0.30.40.60.6-0.6-0.8
Left kidney weight1.02.83.2-1.61.81.7
Right kidney weight0.20.70.9-0.70.90.9
Tail length8.425.425.9-5.15.15.0
Length with tail12.144.444.6-6.76.66.7
Length without tail7.015.216.0-3.93.84.0
Liver weight, left0.71.22.2-1.51.00.5
Liver weight, right0.10.10.20.4-0.1-0.3
Parametrial fat weight0.00.00.0-0.20.0-0.2
Retroperitoneal fat weight0.51.72.51.0-1.3-1.6
Intraocular pressure2.94.06.11.7-1.8-2.5
Extensor digitorum longus weight3.815.116.23.6-4.0-4.0
Soleus weight0.10.30.70.3-0.2-0.8
Tibialis anterior weight2.48.49.62.7-3.1-2.9
Tibia length6.919.421.8-4.44.74.1
Number of licking bursts3.33.94.02.0-1.9-2.0
Food consumed during 24 hour testing period1.01.21.4-1.21.11.0
Times rat made contact with spout0.30.40.50.7-0.5-0.7
Mean time between licks in bursts0.10.10.10.2-0.2-0.4
Mean num. licks in bursts2.22.62.7-1.61.61.6
Std. dev. time between licks in bursts1.01.21.41.1-1.2-1.0
Water consumed over 24 hours0.60.70.80.8-0.8-0.9
Indifference point 0 sec4.97.99.6-2.73.12.6
Indifference point AUC1.21.41.71.3-1.3-1.0
Indifference point function ln k4.86.87.6-2.62.82.4
Indifference point function log k4.86.87.6-2.62.82.4
Delay discounting total patch changes 0 sec6.09.711.3-3.13.42.9
Delay discounting total patch changes 12 sec0.00.00.10.2-0.20.0
Delay discounting total patch changes 18 sec0.00.00.1-0.10.3-0.0
Delay discounting total patch changes 24 sec0.70.90.9-0.90.90.9
Delay discounting total patch changes 6 sec0.81.31.3-1.11.11.1
Delay discounting time to switch 0 sec6.19.310.23.2-3.0-3.0
Delay discounting water rate 0 sec5.58.79.7-3.12.82.9
Delay discounting water rate 12 sec5.37.98.7-2.92.82.7
Delay discounting water rate 18 sec6.07.98.5-2.82.72.9
Delay discounting water rate 24 sec2.83.84.7-2.21.81.9
Delay discounting water rate 6 sec13.519.720.3-4.54.34.5
Locomotor activity0.20.30.5-0.30.50.7
Locomotor testing distance0.40.71.11.0-0.7-0.7
Locomotor testing rearing0.20.40.60.7-0.5-0.6
Light reinforcement 12.24.05.0-2.21.81.9
Light reinforcement 20.10.10.20.3-0.3-0.4
Reaction time number correct8.912.713.0-3.53.53.6
Reaction time mean minus median0.10.10.2-0.30.40.3
Reaction time mean minus median AUC0.50.60.7-0.80.90.7
Reaction time num false alarms0.60.80.91.0-0.8-0.9
Reaction time num false alarms AUC1.01.41.61.2-1.1-1.3
Reaction time trials correct on left8.912.713.0-3.53.53.6
Reaction time trials on left9.112.913.1-3.63.63.6
Reaction time mean1.31.82.01.3-1.3-1.4
Reaction time mean AUC1.11.51.61.3-1.2-1.3
Median of all reaction times2.43.23.51.7-1.8-1.9
Reaction time omissions0.20.30.6-0.80.30.3
Reaction time false alarm rate5.88.28.72.9-2.7-2.9
Reaction time premature initiation rate3.54.75.4-2.12.12.3
Reaction time premature initiations10.615.016.5-3.83.74.1
Std. dev. reaction times0.00.00.10.1-0.2-0.3
Reaction time trials completed9.112.913.1-3.63.63.6
Reaction time trials AUC8.311.811.9-3.43.43.5
Social response proportion0.10.20.30.3-0.5-0.3
Social responses0.91.12.0-0.80.81.4
Social time0.00.00.0-0.10.1-0.1
Conditioned locomotion0.10.10.10.3-0.2-0.3
Cocaine response after cond. corrected1.41.61.7-1.21.31.3
Cocaine response after cond. not corrected1.92.12.4-1.31.51.6
Cocaine response before conditioning0.30.30.4-0.40.60.7
Saline control response1.01.31.5-1.11.11.2
Condit. Reinf. active minus inactive responses3.44.24.6-2.11.92.1
Condit. Reinf. active-inactive response ratio2.22.33.1-1.81.41.4
Condit. Reinf. active responses1.11.61.7-1.31.11.3
Condit. Reinf. inactive responses0.10.10.1-0.20.30.3
Condit. Reinf. lever presses1.72.42.5-1.51.61.5
Condit. Reinf. lever reinforcers received1.62.22.4-1.51.41.5
Pavlov. Cond. lever latency1.62.22.61.3-1.5-1.6
Pavlov. Cond. magazine entry latency0.80.91.3-0.70.91.1
Pavlov. Cond. change in total contacts4.56.37.3-2.42.42.7
Pavlov. Cond. index score2.22.83.5-1.51.61.9
Pavlov. Cond. latency score2.32.93.6-1.51.71.9
Pavlov. Cond. lever contacts1.82.52.7-1.51.61.6
Pavlov. Cond. magazine entry number1.41.72.61.1-1.2-1.6
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.50.20.1
Pavlov. Cond. lever-magazine prob. diff.2.33.03.7-1.51.71.9
Pavlov. Cond. response bias1.41.92.4-1.31.31.5
Conditioned reinforcement - actives2.82.83.3-1.51.81.7
Conditioned reinforcement - inactives0.30.40.6-0.60.80.4
Conditioned locomotion0.60.70.8-0.80.80.9
Intermittent access intake day 1-15 change0.20.20.3-0.60.50.1
Intermittent access intake escalation0.40.40.6-0.80.60.2
Intermittent access intake escalation 20.00.00.0-0.20.2-0.1
Intermitt. access day 1 inactive lever presses2.62.83.11.5-1.7-1.8
Intermitt. access day 15 inactive lever presses3.13.43.81.7-1.9-1.9
Intermitt. access escalation Index0.20.10.2-0.40.30.5
Intermittent access day 1 total infusions1.01.21.5-1.01.21.0
Intermittent access day 15 total infusions2.62.94.0-1.82.01.2
Intermittent access terminal intake (last 3 days)1.21.32.0-1.11.40.9
Intermittent access total infusions2.73.03.9-1.72.01.4
Intermittent access day 1 locomotion2.82.93.3-1.71.81.6
Intermittent access day 15 total locomotion2.32.43.1-1.81.61.3
Intermittent access total locomotion5.46.16.7-2.62.62.3
Intermittent access standard deviation0.30.40.50.6-0.5-0.7
Cocaine induced anxiety0.70.81.2-0.51.01.1
Post-drug Anxiety1.11.21.6-0.91.01.3
Baseline Anxiety0.00.00.1-0.20.00.1
Lifetime Intake2.42.73.6-1.61.91.4
Incentive Sensitization - Responses0.60.60.6-0.80.80.7
Incentive Sensitization - Breakpoint0.40.40.4-0.70.60.5
Progressive ratio test 1 active lever presses1.21.21.5-1.11.21.0
Progressive ratio test 1 breakpoint1.31.41.7-1.11.31.1
Progressive ratio test 1 inactive lever presses0.60.71.0-0.81.00.7
Progressive ratio test 2 active lever presses0.40.40.7-0.70.80.5
Progressive ratio test 2 breakpoint0.30.30.6-0.60.70.4
Progressive ratio test 2 inactive lever presses0.30.40.6-0.70.80.3
Total sessions with >9 infusions0.91.01.4-0.91.21.0
Short access day 1 total inactive lever presses0.10.10.1-0.40.3-0.0
Short access day 10 total inactive lever presses0.91.01.50.9-1.2-0.7
Short access day 1 total infusions1.61.82.6-1.21.61.1
Short access day 10 total infusions1.51.72.2-1.21.51.2
Short access total infusions2.12.43.0-1.51.71.4
Short access day 1 locomotion0.50.50.7-0.70.80.5
Short access day 10 total locomotion0.00.00.1-0.20.2-0.0
Short access total locomotion2.22.32.7-1.71.61.3
Compulsive drug intake0.30.30.60.4-0.8-0.4
One hour access (0.3 mA shock)1.41.62.1-1.31.51.0
One hour access (shock baseline)2.83.24.4-1.72.11.5
Number of responses in last shaping day0.30.30.40.5-0.3-0.7
Context. condit. distance diff. score1.41.82.2-1.11.41.5
Locomotion velocity, session 10.30.40.4-0.60.50.6
Locomotion distance, session 10.70.91.0-0.81.01.0
Locomotion velocity, session 24.04.74.7-2.22.12.2
Locomotion distance, session 20.50.71.0-0.70.91.0
Locomotion velocity, session 34.35.05.6-2.22.12.4
Locomotion distance, session 36.97.58.3-2.62.72.9
Stereotopy head waving bouts, day 30.50.60.8-0.90.90.5
Stereotopy head waving duration, day 30.00.10.1-0.30.2-0.2
Locomotion velocity, session 70.10.10.1-0.40.40.3
Locomotion distance, session 70.40.50.5-0.60.70.7
Stereotopy head waving bouts, day 70.00.00.1-0.2-0.0-0.3
Stereotopy head waving duration, day 70.10.20.3-0.60.40.2
Locomotion velocity, session 82.63.13.2-1.81.81.7
Locomotion distance, session 83.55.36.4-2.02.32.5
Degree of sensitization distance2.82.83.61.5-1.6-1.9
Degree of sensitization stereotypy0.00.00.1-0.0-0.2-0.2
Condit. Reinf. active minus inactive responses1.11.22.10.8-0.9-1.5
Condit. Reinf. active-inactive response ratio1.11.22.10.8-0.9-1.5
Condit. Reinf. active responses0.10.10.30.1-0.2-0.6
Condit. Reinf. inactive responses1.01.21.5-1.01.01.2
Incentive salience index mean0.81.01.60.8-0.9-1.3
Condit. Reinf. lever presses0.40.50.50.7-0.7-0.7
Time in familiar zone, hab. session 14.44.14.4-2.02.02.1
Time in novel zone, hab. session 16.26.06.42.3-2.5-2.5
Total zone transitions, hab. session 10.00.00.0-0.1-0.10.2
Total locomotion distance, hab. session 10.00.10.10.2-0.00.4
Locomotion velocity, hab. session 10.00.00.10.1-0.00.3
Time in familiar zone, hab. session 21.31.41.8-1.11.11.3
Time in novel zone, hab. session 21.71.72.21.2-1.2-1.5
Total zone transitions, hab. session 20.10.10.2-0.40.10.4
Total locomotion distance, hab. session 20.10.10.20.5-0.40.0
Locomotion velocity, hab. session 20.00.00.10.1-0.00.3
Novel to familiar place preference ratio2.02.12.31.5-1.3-1.5
Novelty place preference1.41.51.81.2-1.1-1.3
Time in novel zone, NPP test1.51.62.01.2-1.2-1.4
Total zone transitions, NPP test1.42.02.3-1.51.21.5
Total locomotion distance, NPP test0.10.10.2-0.10.10.5
Locomotion velocity, NPP test0.50.71.0-0.70.71.0
Pavlov. Cond. lever latency0.00.00.10.1-0.2-0.3
Pavlov. Cond. magazine entry latency1.52.03.3-1.21.11.8
Pavlov. Cond. change in total contacts3.03.23.8-1.71.72.0
Pavlov. Cond. index score0.40.50.9-0.50.50.9
Pavlov. Cond. latency score0.10.10.3-0.20.20.6
Pavlov. Cond. lever contacts0.40.40.7-0.50.60.8
Pavlov. Cond. magazine entry number1.62.03.51.1-1.1-1.9
Pavlov. Cond. intertrial magazine entries4.45.37.12.1-2.1-2.7
Pavlov. Cond. lever-magazine prob. diff.0.50.71.1-0.70.71.1
Pavlov. Cond. response bias1.72.13.2-1.31.31.8
Bone: apparent density0.71.21.21.1-1.1-1.0
Bone surface0.10.10.20.4-0.2-0.2
Bone volume0.20.30.40.6-0.5-0.4
Bone: connectivity density0.10.10.10.3-0.3-0.3
Bone: cortical apparent density0.10.20.2-0.50.40.3
Bone: cortical area0.20.20.4-0.50.60.3
Bone: cortical porosity1.11.22.00.8-1.0-1.4
Bone: cortical porosity1.11.11.90.9-0.8-1.4
Bone: cortical thickness0.30.40.6-0.80.80.3
Bone: cortical thickness0.70.81.1-0.80.91.0
Bone: cortical tissue density0.20.20.3-0.50.50.4
Bone: elastic displacement1.31.41.71.3-1.0-1.3
Bone: elastic work0.60.81.21.1-0.7-0.9
Bone: endosteal estimation0.20.30.6-0.30.60.8
Bone: endosteal perimeter0.00.10.20.4-0.1-0.1
Bone: final force0.71.21.7-0.81.31.1
Bone: final moment1.01.62.2-1.01.51.2
Bone: marrow area0.10.30.5-0.30.60.7
Bone: maximum diameter0.40.81.01.0-0.8-0.9
Bone: maximum force0.20.30.6-0.20.70.5
Bone: maximum moment0.30.61.0-0.51.00.7
Bone: minimum diameter1.93.64.0-1.82.01.9
Bone: periosteal estimation0.10.30.4-0.40.60.6
Bone: periosteal perimeter0.00.00.10.00.30.2
Bone: post-yield work0.00.00.0-0.2-0.1-0.1
Bone: stiffness0.30.50.8-0.40.90.8
Bone: tissue strength0.80.81.10.9-0.7-1.0
Bone: trabecular number0.00.00.10.2-0.3-0.1
Bone: trabecular spacing0.10.10.1-0.2-0.4-0.4
Bone: trabecular thickness1.11.32.01.4-0.9-1.0
Bone: trabecular tissue density2.43.33.41.8-1.8-1.8
Breakpoint value in progressive ratio session3.13.44.22.0-1.8-1.7
Distance traveled before self-admin2.22.42.8-1.41.71.5
Distance traveled after self-admin1.31.51.8-1.31.01.3
Delta time in closed arm before/after self-admin4.54.45.82.4-2.0-1.9
Delta time in open arm before/after self-admin0.00.00.00.00.1-0.1
Diff in mean of infusions in LGA sessions0.30.30.40.5-0.6-0.6
Extinction: sum of active levers before priming1.71.72.31.5-1.2-1.2
Active lever presses in extinction session 62.32.22.51.6-1.5-1.4
Delta distance traveled before/after self-admin0.30.30.5-0.70.30.7
Delta ambulatory time before/after self-admin0.30.30.6-0.60.30.7
Time in closed arm before self-admin0.00.00.0-0.2-0.10.2
Time in closed arm after self-admin0.70.71.10.9-1.0-0.6
Time in open arm before self-admin0.20.20.4-0.10.60.3
Time in open arm after self-admin0.20.20.40.4-0.2-0.6
Sum of active levers in priming session hrs 5-60.90.91.00.8-1.0-1.0
Time to tail flick, vehicle, before self-admin4.54.64.8-2.22.22.1
Time to tail flick, vehicle, after self-admin1.51.62.2-1.01.21.5
Time to tail flick, test, before self-admin0.10.10.1-0.40.20.3
Time to tail flick, test, after self-admin0.60.60.90.4-1.0-0.9
Delta time to tail flick, vehicle, before/after SA1.41.31.81.4-1.1-0.9
Delta time to tail flick, test, before/after SA0.10.10.10.2-0.4-0.3
Ambulatory time before self-admin0.70.80.8-0.80.90.9
Ambulatory time after self-admin0.60.71.1-0.90.51.0
Total heroin consumption1.21.51.61.2-1.2-1.3
Area under the delay curve0.30.30.7-0.10.40.8
Delay disc. indifference point, 0s delay0.10.10.20.3-0.3-0.4
Delay disc. indifference point, 16s delay0.70.71.1-0.31.01.1
Delay disc. indifference point, 2s delay0.00.00.1-0.0-0.2-0.3
Delay disc. indifference point, 24s delay0.70.71.1-0.11.01.0
Delay disc. indifference point, 4s delay0.00.00.0-0.10.10.2
Delay disc. indifference point, 8s delay0.10.10.20.5-0.20.4
Delay discount exponential model param0.30.30.70.1-0.5-0.8
Delay discount hyperbolic model param0.20.20.50.1-0.4-0.7
Fecal boli incidents, locomotor time 12.32.64.12.0-1.1-1.5
Change in fecal boli incidents, locomotor task0.10.10.2-0.3-0.4-0.1
Time >=10cm from walls, locomotor time 11.61.61.91.2-1.2-1.4
Bouts of movement, locomotor time 10.40.40.70.8-0.5-0.6
Total resting periods, locomotor time 10.10.20.40.60.1-0.2
Rest time, locomotor task time 11.92.02.61.6-1.3-1.3
Distance moved, locomotor task time 12.02.23.4-1.81.11.4
Vertical activity count, locomotor time 11.31.42.4-1.60.51.2
Time >=10cm from walls, locomotor time 20.80.91.31.1-0.7-0.9
Bouts of movement, locomotor time 20.10.10.2-0.10.00.5
Total resting periods, locomotor time 20.10.10.20.3-0.4-0.0
Rest time, locomotor task time 23.44.04.52.1-1.7-2.1
Distance moved, locomotor task time 21.72.02.5-1.61.01.6
Vertical activity count, locomotor time 20.50.51.2-1.10.00.7
Weight adjusted by age0.30.30.7-0.80.30.4
Seeking ratio, delayed vs. immediate footshock1.31.51.61.3-1.2-1.2
Locomotion in novel chamber1.11.31.81.0-1.3-1.0
Locomotion in novel chamber post-restriction0.10.20.40.6-0.3-0.2
Progressive ratio0.00.00.00.1-0.0-0.1
Food seeking constrained by brief footshock2.22.72.9-1.51.71.7
Seeking ratio, punishment vs. effort0.60.80.8-0.80.90.9
Run reversals in cocaine runway, females0.90.91.50.7-1.2-0.8
Run reversals in cocaine runway, males0.20.20.50.7-0.10.2
Latency to leave start box in cocaine runway2.62.83.21.8-1.6-1.6
Latency to leave start box in cocaine runway, F0.40.40.50.7-0.5-0.6
Latency to leave start box in cocaine runway, M3.23.13.81.8-2.0-1.5
Cd content in liver0.40.50.6-0.70.60.7
Co content in liver0.20.20.3-0.10.60.5
Cu content in liver0.40.50.7-0.80.90.4
Fe content in liver1.61.92.4-1.51.31.3
K content in liver2.02.03.3-1.11.21.8
Mg content in liver0.30.30.8-0.00.30.9
Mn content in liver0.40.40.4-0.70.60.6
Na content in liver0.20.20.3-0.30.60.5
Rb content in liver1.01.31.8-1.01.31.0
Se content in liver0.10.20.30.1-0.5-0.4
Sr content in liver2.72.43.41.8-1.4-1.4
Zn content in liver0.00.00.00.2-0.20.1