Fam219a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000039559	0.03	0.02	4.1e-04	0.03	0.02	0.02	0.02	3.5e-04	1.0e-03	1.2e-03	1.3e-03
2	BLA	gene expression	ENSRNOG00000039559	0.09	0.06	4.6e-04	0.05	0.06	0.03	0.05	1.1e-03	2.9e-04	7.2e-03	7.5e-04
3	Brain	gene expression	ENSRNOG00000039559	0.04	0.04	3.1e-03	0.02	0.01	0.01	0.02	3.7e-03	1.8e-02	2.4e-02	4.4e-03
4	Brain	isoform ratio	ENSRNOT00000060642	0.04	0.03	4.1e-03	0.02	0.01	0.02	0.01	1.1e-02	2.0e-02	6.8e-03	2.4e-02
5	Brain	isoform ratio	ENSRNOT00000116318	0.03	0.03	6.2e-03	0.01	0.01	0.02	0.01	8.3e-02	3.5e-02	2.5e-03	5.1e-02
6	Brain	mRNA stability	ENSRNOG00000039559	0.07	0.05	5.1e-05	0.06	0.05	0.05	0.05	3.6e-06	3.4e-05	2.3e-05	1.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	2.3	7.5	13.8	-2.9	2.3	2.5	3.7	-3.3	0.9
BMI without tail	4.5	9.4	15.6	-3.3	3.5	4.0	3.3	-2.5	-0.6
Body weight	3.3	14.1	22.2	-3.7	3.8	4.1	4.7	-4.3	-0.5
Epididymis fat weight	1.3	3.1	7.1	-1.1	1.3	1.3	2.4	-2.7	-0.9
Glucose	0.8	1.2	2.2	-1.2	1.3	1.5	1.2	-0.6	-0.3
Heart weight	1.6	2.3	5.1	-0.8	1.1	1.4	2.1	-2.3	-0.4
Left kidney weight	1.2	3.5	7.4	-0.5	1.5	1.5	2.7	-2.7	-1.4
Right kidney weight	0.6	1.6	4.9	0.3	0.5	0.5	1.8	-2.2	-1.0
Tail length	1.7	5.1	11.9	-2.5	3.1	3.5	1.4	-0.5	-1.1
Length with tail	0.8	3.0	5.5	-1.2	2.1	2.3	1.5	-1.4	-1.6
Length without tail	0.3	0.7	1.2	1.1	-0.8	-1.0	0.2	-1.0	-0.5
Liver weight, left	0.4	0.7	1.2	-0.9	1.0	1.1	0.9	-0.4	-0.3
Liver weight, right	0.0	0.1	0.1	0.3	-0.0	-0.1	-0.3	0.2	-0.3
Parametrial fat weight	0.2	0.4	1.0	-0.3	0.7	1.0	0.6	-0.4	-0.7
Retroperitoneal fat weight	0.2	0.5	1.6	0.2	-0.6	-0.5	0.7	-1.3	0.5
Intraocular pressure	1.3	1.9	4.0	-1.3	2.0	2.0	1.0	-0.6	-0.7
Extensor digitorum longus weight	3.7	15.0	22.2	-4.3	4.7	4.7	4.2	-3.1	-0.7
Soleus weight	0.6	1.8	7.9	0.9	0.5	0.5	0.4	-1.3	-2.8
Tibialis anterior weight	5.9	20.2	31.5	-4.7	5.5	5.6	4.7	-3.4	-1.8
Tibia length	0.6	1.7	4.6	0.4	0.7	0.5	1.3	-2.1	-1.8
Number of licking bursts	3.8	4.5	7.5	-2.7	2.6	2.5	2.1	-1.3	0.2
Food consumed during 24 hour testing period	1.3	1.5	2.4	-1.0	1.3	1.2	1.6	-1.3	-0.9
Times rat made contact with spout	0.3	0.3	0.7	-0.8	0.6	0.6	0.5	-0.0	0.6
Mean time between licks in bursts	0.2	0.3	0.5	0.6	-0.7	-0.7	-0.6	0.3	0.1
Mean num. licks in bursts	2.0	2.5	3.6	1.8	-1.9	-1.8	-1.6	1.3	0.4
Std. dev. time between licks in bursts	0.3	0.3	0.6	0.6	-0.8	-0.8	0.3	-0.5	0.4
Water consumed over 24 hours	1.4	1.7	3.4	-1.1	1.2	1.0	1.9	-1.7	-0.1
Indifference point 0 sec	2.6	4.2	9.6	0.4	1.2	1.0	2.0	-3.0	-3.1
Indifference point AUC	5.0	5.9	10.1	-2.8	3.0	3.2	2.4	-1.6	-0.7
Indifference point function ln k	1.3	1.8	3.7	1.8	-1.7	-1.9	-1.0	0.3	0.1
Indifference point function log k	1.3	1.8	3.7	1.8	-1.7	-1.9	-1.0	0.3	0.1
Delay discounting total patch changes 0 sec	3.0	4.9	10.9	-0.0	1.6	1.4	2.4	-3.3	-2.9
Delay discounting total patch changes 12 sec	2.2	3.0	5.3	-1.6	1.6	1.9	2.3	-2.0	-0.4
Delay discounting total patch changes 18 sec	0.6	0.8	1.2	-0.7	1.1	1.1	0.6	-0.7	-1.1
Delay discounting total patch changes 24 sec	2.3	2.9	3.5	-1.3	1.9	1.8	1.9	-1.8	-1.4
Delay discounting total patch changes 6 sec	4.2	6.4	10.7	-1.2	2.4	2.4	3.1	-3.3	-2.3
Delay discounting time to switch 0 sec	2.0	3.1	4.7	1.5	-2.2	-2.1	-1.8	1.5	1.4
Delay discounting water rate 0 sec	1.7	2.7	3.6	-1.0	1.8	1.8	1.7	-1.6	-1.9
Delay discounting water rate 12 sec	0.1	0.1	0.4	0.1	0.4	0.1	-0.1	-0.3	-0.6
Delay discounting water rate 18 sec	0.3	0.3	0.8	-0.7	0.4	0.4	0.7	-0.2	0.9
Delay discounting water rate 24 sec	0.3	0.4	1.5	-0.3	-0.4	-0.4	-0.2	0.4	1.2
Delay discounting water rate 6 sec	0.6	0.8	1.7	-1.3	1.3	1.0	0.7	-0.3	-0.1
Locomotor activity	0.2	0.3	0.8	-0.1	0.2	0.1	0.8	-0.9	0.3
Locomotor testing distance	0.2	0.4	1.0	0.3	0.3	0.1	0.6	-1.0	-0.8
Locomotor testing rearing	1.0	1.6	2.5	-1.3	1.6	1.2	1.4	-1.3	-0.6
Light reinforcement 1	2.9	5.3	8.7	-0.6	2.2	2.0	2.3	-2.9	-2.9
Light reinforcement 2	3.0	4.0	8.9	0.5	1.4	1.3	1.9	-2.7	-3.0
Reaction time number correct	0.1	0.1	0.5	0.0	0.3	0.2	0.2	-0.1	-0.7
Reaction time mean minus median	1.2	1.6	7.0	-1.2	-0.1	0.5	0.1	0.8	2.6
Reaction time mean minus median AUC	1.0	1.3	4.2	-1.5	0.5	0.9	0.6	0.1	2.1
Reaction time num false alarms	0.4	0.6	1.4	-0.2	-0.1	-0.1	-0.8	1.2	1.2
Reaction time num false alarms AUC	0.2	0.3	0.4	-0.6	0.6	0.6	0.0	0.5	0.6
Reaction time trials correct on left	0.1	0.1	0.5	0.0	0.3	0.2	0.2	-0.1	-0.7
Reaction time trials on left	0.1	0.1	0.5	0.1	0.2	0.1	0.0	0.0	-0.7
Reaction time mean	2.4	3.4	6.3	0.4	-1.7	-1.3	-2.3	2.5	2.0
Reaction time mean AUC	3.4	4.5	9.1	0.5	-1.8	-1.5	-2.7	3.0	2.2
Median of all reaction times	3.7	4.9	9.4	1.2	-2.1	-1.9	-3.1	3.0	1.2
Reaction time omissions	1.4	1.9	3.5	1.2	-1.5	-1.3	-1.9	1.5	0.5
Reaction time false alarm rate	0.3	0.4	1.1	-0.1	-0.2	-0.1	-0.5	0.9	1.1
Reaction time premature initiation rate	1.6	2.1	3.9	1.4	-2.0	-1.7	-1.2	0.8	1.4
Reaction time premature initiations	1.0	1.4	2.6	1.2	-1.6	-1.5	-0.9	0.6	0.9
Std. dev. reaction times	1.3	1.8	7.0	-0.6	-0.9	-0.3	-0.8	1.4	2.6
Reaction time trials completed	0.1	0.1	0.5	0.1	0.2	0.1	0.0	0.0	-0.7
Reaction time trials AUC	0.1	0.1	0.4	0.1	0.2	0.1	0.0	-0.0	-0.6
Social response proportion	1.1	1.2	3.1	1.0	-1.8	-1.5	-0.6	0.6	0.5
Social responses	0.4	0.5	1.0	-1.0	0.8	0.9	0.7	-0.2	-0.2
Social time	0.1	0.2	0.7	0.2	-0.1	-0.1	-0.5	0.4	-0.8
Conditioned locomotion	0.3	0.4	1.5	0.4	0.2	0.1	-0.5	0.4	-1.2
Cocaine response after cond. corrected	1.4	1.6	3.5	1.9	-0.8	-1.0	-1.0	-0.2	-1.8
Cocaine response after cond. not corrected	1.3	1.4	4.2	1.7	-0.5	-0.8	-0.6	-0.6	-2.0
Cocaine response before conditioning	0.7	0.8	1.5	-1.2	1.1	1.1	0.9	-0.6	0.2
Saline control response	1.4	1.9	2.7	-0.6	1.6	1.5	1.3	-1.5	-1.5
Condit. Reinf. active minus inactive responses	0.7	0.8	1.5	-1.0	0.8	0.9	1.2	-0.9	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	0.0	0.2	0.5	-0.3	0.4
Condit. Reinf. active responses	1.6	2.2	3.7	-1.9	1.8	1.9	1.4	-0.8	0.1
Condit. Reinf. inactive responses	2.1	2.6	5.5	-2.4	1.9	2.0	1.3	-0.3	0.7
Condit. Reinf. lever presses	1.9	2.6	4.6	-2.1	1.5	1.6	1.9	-1.0	1.3
Condit. Reinf. lever reinforcers received	1.9	2.6	4.3	-2.1	2.0	2.0	1.7	-1.0	0.1
Pavlov. Cond. lever latency	1.7	2.3	5.2	2.3	-1.6	-1.7	-0.3	-1.0	-1.5
Pavlov. Cond. magazine entry latency	1.8	2.1	6.3	0.3	-0.6	-0.6	-2.2	2.5	0.7
Pavlov. Cond. change in total contacts	1.1	1.6	4.6	-1.6	0.4	0.6	-0.2	1.3	2.2
Pavlov. Cond. index score	1.5	2.0	6.3	-0.8	0.2	0.2	-1.6	2.5	1.5
Pavlov. Cond. latency score	1.6	2.1	6.4	-1.0	0.3	0.4	-1.5	2.5	1.6
Pavlov. Cond. lever contacts	1.0	1.3	2.5	-1.6	1.1	1.2	-0.3	1.3	1.1
Pavlov. Cond. magazine entry number	2.1	2.6	8.1	0.7	0.2	0.0	1.9	-2.8	-1.8
Pavlov. Cond. intertrial magazine entries	1.4	1.7	4.8	-0.5	0.7	0.7	2.0	-2.2	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	6.2	-0.8	0.1	0.2	-1.5	2.5	1.6
Pavlov. Cond. response bias	0.9	1.2	2.8	-1.2	0.6	0.7	-0.7	1.7	1.3
Conditioned reinforcement - actives	0.4	0.4	1.3	-1.1	0.6	0.0	0.7	-0.4	0.5
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.4	0.5	-0.2	0.4	-0.4	-0.1
Conditioned locomotion	1.0	1.3	3.0	-1.1	0.8	0.5	1.6	-1.7	-0.0
Intermittent access intake day 1-15 change	0.7	0.7	2.2	-1.5	0.5	0.6	0.6	-0.0	1.0
Intermittent access intake escalation	1.0	1.0	2.5	-1.6	0.8	1.0	1.1	-0.6	0.4
Intermittent access intake escalation 2	1.1	1.1	3.5	-1.9	0.8	0.8	0.6	0.2	1.1
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.1	-0.8	0.9	1.0	0.9	-0.7	-0.6
Intermitt. access day 15 inactive lever presses	0.4	0.5	0.9	0.1	0.6	0.5	0.8	-0.9	-0.8
Intermitt. access escalation Index	1.1	0.9	2.2	-0.5	1.2	1.5	0.9	-0.7	-0.7
Intermittent access day 1 total infusions	0.3	0.4	1.2	1.1	-0.5	-0.7	-0.3	-0.3	-0.6
Intermittent access day 15 total infusions	0.4	0.4	0.7	-0.8	0.7	0.6	0.8	-0.7	-0.1
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.6	-1.2	1.1	0.7	1.2	-1.0	-0.2
Intermittent access total infusions	0.7	0.7	1.2	-0.9	1.0	0.7	1.1	-0.8	-0.4
Intermittent access day 1 locomotion	1.0	1.0	2.6	1.6	-1.1	-1.1	-0.9	0.3	-0.4
Intermittent access day 15 total locomotion	0.4	0.5	0.9	1.0	-0.9	-1.0	-0.4	0.1	0.0
Intermittent access total locomotion	0.6	0.7	1.0	0.7	-0.9	-1.0	-0.8	0.7	0.7
Intermittent access standard deviation	0.5	0.5	1.4	-1.2	0.7	0.5	0.9	-0.6	0.2
Cocaine induced anxiety	0.6	0.6	1.4	0.9	-0.8	-1.2	-0.8	0.5	-0.3
Post-drug Anxiety	0.4	0.4	0.7	-0.7	0.8	0.8	0.7	-0.5	-0.3
Baseline Anxiety	0.8	0.8	1.4	-1.2	0.8	1.2	1.0	-0.6	0.6
Lifetime Intake	1.1	1.3	1.8	-0.7	1.3	0.9	1.3	-1.2	-1.1
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.3	0.6	0.2	0.4	-0.1	-0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.1	0.4	0.0	0.1	0.1	-0.5
Progressive ratio test 1 active lever presses	0.2	0.2	0.7	-0.1	0.8	0.5	0.3	-0.1	-0.6
Progressive ratio test 1 breakpoint	0.4	0.4	1.0	-0.3	1.0	0.6	0.5	-0.3	-0.7
Progressive ratio test 1 inactive lever presses	0.9	1.0	2.4	0.0	1.3	1.1	0.5	-0.6	-1.6
Progressive ratio test 2 active lever presses	0.3	0.4	1.1	0.1	0.6	0.1	0.6	-0.6	-1.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	0.4	0.3	-0.1	0.2	-0.3	-0.8
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.7	-0.8	0.9	0.5	1.3	-1.3	-0.5
Total sessions with >9 infusions	0.5	0.6	1.8	0.2	0.7	0.2	0.6	-0.8	-1.3
Short access day 1 total inactive lever presses	3.2	3.6	5.5	-1.6	2.1	1.9	2.3	-2.0	-1.3
Short access day 10 total inactive lever presses	0.6	0.7	1.2	-0.7	0.7	0.7	1.1	-1.1	-0.4
Short access day 1 total infusions	2.7	2.8	4.1	-1.0	2.0	1.5	1.8	-1.9	-1.7
Short access day 10 total infusions	1.3	1.5	2.7	-0.3	1.1	1.0	1.5	-1.6	-1.4
Short access total infusions	0.9	1.0	2.2	-0.3	1.2	0.7	1.0	-1.0	-1.5
Short access day 1 locomotion	0.1	0.2	0.5	0.6	-0.2	-0.1	-0.2	-0.1	-0.7
Short access day 10 total locomotion	1.1	1.2	1.7	0.7	-1.2	-1.3	-1.2	1.1	0.9
Short access total locomotion	0.0	0.0	0.1	0.2	0.1	0.2	0.1	-0.1	-0.3
Compulsive drug intake	0.1	0.1	0.2	-0.3	0.3	0.3	0.5	-0.2	-0.5
One hour access (0.3 mA shock)	0.4	0.5	0.9	-0.2	0.8	0.5	0.9	-0.7	-1.0
One hour access (shock baseline)	0.5	0.6	1.4	-0.1	0.8	0.6	0.8	-0.8	-1.2
Number of responses in last shaping day	2.2	2.2	5.4	0.2	1.1	1.1	1.4	-1.9	-2.3
Context. condit. distance diff. score	0.1	0.1	0.3	0.1	-0.5	-0.4	-0.4	0.5	0.3
Locomotion velocity, session 1	2.5	2.7	10.9	0.4	1.4	1.1	0.5	-1.3	-3.3
Locomotion distance, session 1	0.8	1.0	4.0	-0.1	0.9	0.9	0.5	-0.5	-2.0
Locomotion velocity, session 2	1.3	1.5	3.2	-1.8	1.4	1.5	1.0	-0.5	0.5
Locomotion distance, session 2	1.9	2.7	4.2	-1.6	2.1	2.1	1.4	-1.0	-1.6
Locomotion velocity, session 3	0.6	0.7	3.3	0.3	0.6	0.5	-0.1	-0.1	-1.8
Locomotion distance, session 3	1.9	2.0	3.3	-1.2	1.8	1.8	1.3	-0.9	-1.4
Stereotopy head waving bouts, day 3	0.7	0.9	2.0	0.8	0.3	-0.1	-1.4	0.8	-1.4
Stereotopy head waving duration, day 3	0.7	0.9	2.6	0.9	-0.2	-0.6	-1.6	0.9	-0.6
Locomotion velocity, session 7	0.2	0.2	0.7	0.1	-0.2	-0.1	-0.8	0.8	-0.0
Locomotion distance, session 7	0.2	0.2	0.5	-0.5	0.6	0.7	0.0	0.1	-0.5
Stereotopy head waving bouts, day 7	1.3	1.4	3.3	-1.1	1.8	1.7	0.9	-0.4	-0.5
Stereotopy head waving duration, day 7	0.4	0.4	1.2	-0.4	1.1	0.9	0.4	-0.2	-0.5
Locomotion velocity, session 8	0.4	0.5	2.3	0.1	0.5	0.4	-0.2	0.1	-1.5
Locomotion distance, session 8	0.4	0.6	2.1	-0.3	0.8	0.8	0.4	-0.1	-1.4
Degree of sensitization distance	1.3	1.3	2.7	0.8	-1.1	-1.1	-1.6	1.4	0.8
Degree of sensitization stereotypy	0.8	0.8	1.6	-0.9	1.3	1.2	1.0	-0.5	-0.1
Condit. Reinf. active minus inactive responses	0.3	0.4	1.0	-1.0	0.7	0.8	0.1	0.4	0.1
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.6	0.6	-0.9	-0.9	-1.3	1.3	0.6
Condit. Reinf. active responses	1.7	2.1	4.9	-2.2	1.8	1.9	0.8	0.2	0.1
Condit. Reinf. inactive responses	2.1	2.5	5.8	-2.4	1.9	2.0	1.3	-0.3	0.3
Incentive salience index mean	3.1	3.7	6.2	-2.5	2.4	2.5	1.7	-0.8	-0.5
Condit. Reinf. lever presses	8.4	11.3	17.2	-3.7	4.1	4.1	3.4	-2.4	-1.6
Time in familiar zone, hab. session 1	3.0	2.9	6.6	-0.2	-1.2	-0.9	-1.6	2.4	2.6
Time in novel zone, hab. session 1	2.0	1.9	5.2	1.9	-0.5	-0.8	-1.4	0.3	-2.3
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.2	-0.1	0.1	0.3	-0.0	-0.1
Total locomotion distance, hab. session 1	0.5	0.7	1.5	-1.2	0.2	0.4	1.1	-0.2	1.2
Locomotion velocity, hab. session 1	1.7	2.5	5.7	-2.0	1.0	1.3	2.4	-1.3	0.9
Time in familiar zone, hab. session 2	1.0	1.0	3.1	0.2	-1.2	-1.1	-0.3	0.6	1.8
Time in novel zone, hab. session 2	1.5	1.5	2.9	1.6	-0.5	-0.8	-1.5	0.5	-1.7
Total zone transitions, hab. session 2	0.8	1.0	2.6	-0.6	1.0	1.0	0.8	-0.4	-1.6
Total locomotion distance, hab. session 2	0.6	0.9	1.4	-1.2	1.0	1.1	1.1	-0.4	-0.6
Locomotion velocity, hab. session 2	0.9	1.2	1.9	-1.4	1.1	1.2	1.4	-0.6	-0.5
Novel to familiar place preference ratio	3.2	3.3	5.7	2.3	-1.5	-1.7	-2.4	1.4	-1.3
Novelty place preference	3.6	3.8	6.8	2.6	-1.9	-2.1	-2.3	1.3	-1.0
Time in novel zone, NPP test	4.6	4.8	8.2	2.9	-2.0	-2.3	-2.7	1.6	-1.1
Total zone transitions, NPP test	0.9	1.3	3.0	-0.7	1.2	1.2	1.0	-0.6	-1.7
Total locomotion distance, NPP test	2.1	2.9	4.3	-1.3	1.7	1.9	2.1	-1.4	-1.6
Locomotion velocity, NPP test	2.9	4.1	7.7	-1.7	1.9	2.1	2.8	-2.1	-1.4
Pavlov. Cond. lever latency	7.2	9.1	12.3	3.2	-3.5	-3.4	-3.5	2.8	0.9
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	-0.9	0.7	0.8	0.5	-0.3	0.1
Pavlov. Cond. change in total contacts	2.8	3.0	4.3	-1.7	2.0	1.9	2.1	-1.7	-0.7
Pavlov. Cond. index score	2.8	3.6	5.1	-2.3	2.2	2.2	2.1	-1.6	-0.2
Pavlov. Cond. latency score	2.6	3.3	4.6	-2.1	2.1	2.1	2.1	-1.6	-0.2
Pavlov. Cond. lever contacts	4.6	5.4	7.8	-2.6	2.8	2.7	2.5	-1.9	-0.6
Pavlov. Cond. magazine entry number	0.6	0.8	1.5	1.2	-1.0	-1.1	-0.8	0.5	0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	-0.6	0.4	0.5	0.4	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	4.8	-2.2	1.9	2.0	1.9	-1.3	0.1
Pavlov. Cond. response bias	2.5	3.1	4.6	-2.1	2.1	2.2	1.8	-1.3	-0.4
Bone: apparent density	1.4	2.3	4.7	-1.6	1.2	1.4	2.2	-1.7	0.6
Bone surface	0.6	1.0	1.6	-1.0	1.2	1.2	1.0	-0.8	-0.5
Bone volume	0.6	0.9	1.3	-1.1	1.1	1.2	1.1	-0.8	-0.0
Bone: connectivity density	0.8	1.2	2.5	-1.1	0.7	0.9	1.6	-1.3	0.7
Bone: cortical apparent density	0.6	0.7	2.7	-0.3	-0.6	-0.4	-0.4	1.0	1.7
Bone: cortical area	2.0	3.1	4.9	-2.2	1.6	1.8	2.2	-1.5	0.7
Bone: cortical porosity	0.3	0.4	0.7	0.7	-0.8	-0.8	0.2	-0.4	0.3
Bone: cortical porosity	0.2	0.2	0.5	0.1	-0.1	-0.1	0.7	-0.7	0.1
Bone: cortical thickness	1.0	1.6	2.8	-1.6	0.7	0.9	1.7	-1.0	1.5
Bone: cortical thickness	0.2	0.2	1.0	-0.0	-0.5	-0.3	0.1	0.1	1.0
Bone: cortical tissue density	0.5	0.7	2.3	-0.2	-0.6	-0.5	-0.5	1.0	1.5
Bone: elastic displacement	4.3	4.9	7.6	2.1	-2.8	-2.6	-2.3	2.0	1.1
Bone: elastic work	2.6	3.4	6.5	0.8	-2.2	-2.0	-1.4	1.6	2.6
Bone: endosteal estimation	0.7	1.4	3.2	-1.0	1.8	1.7	0.2	-0.1	-1.2
Bone: endosteal perimeter	0.9	1.9	3.5	-1.1	1.9	1.8	0.8	-0.9	-1.5
Bone: final force	2.2	3.6	7.4	-1.5	1.5	1.6	2.7	-2.7	0.1
Bone: final moment	1.6	2.6	5.4	-1.4	1.2	1.3	2.3	-2.2	0.4
Bone: marrow area	0.7	1.4	3.2	-1.2	1.8	1.7	0.3	-0.1	-1.0
Bone: maximum diameter	1.7	3.2	5.0	-2.2	2.1	2.1	1.9	-1.4	-0.0
Bone: maximum force	3.3	5.7	10.0	-2.4	2.3	2.4	3.2	-2.7	0.2
Bone: maximum moment	2.4	4.1	7.3	-2.1	1.9	2.0	2.7	-2.2	0.5
Bone: minimum diameter	0.0	0.1	0.3	0.1	-0.4	-0.3	-0.1	0.1	0.6
Bone: periosteal estimation	1.1	2.2	3.8	-1.7	1.9	1.9	1.3	-0.9	-0.4
Bone: periosteal perimeter	0.5	0.8	1.4	-0.7	1.2	1.1	0.4	-0.5	-1.1
Bone: post-yield work	1.6	2.2	2.9	-1.2	1.7	1.6	1.6	-1.6	-1.1
Bone: stiffness	4.6	7.2	12.9	-2.7	2.6	2.7	3.6	-3.0	0.2
Bone: tissue strength	0.1	0.1	0.3	-0.5	0.4	0.4	0.5	-0.1	0.1
Bone: trabecular number	1.9	2.9	6.5	-1.6	1.1	1.3	2.5	-2.2	0.9
Bone: trabecular spacing	0.1	0.2	0.5	-0.2	-0.2	-0.1	-0.3	0.6	0.7
Bone: trabecular thickness	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.3	0.2	0.4
Bone: trabecular tissue density	1.6	2.2	4.5	-1.9	2.1	2.1	0.8	0.3	-0.0
Breakpoint value in progressive ratio session	1.3	1.4	3.8	1.3	-0.2	-0.1	0.9	-1.9	-1.5
Distance traveled before self-admin	4.9	5.2	8.6	-2.2	2.9	2.8	2.4	-1.6	-1.4
Distance traveled after self-admin	1.0	1.1	3.0	-1.7	1.3	0.9	0.9	-0.4	0.6
Delta time in closed arm before/after self-admin	1.2	1.1	3.1	-1.7	1.0	1.4	0.3	0.1	0.7
Delta time in open arm before/after self-admin	0.3	0.3	0.5	0.7	-0.3	-0.6	0.5	-0.6	-0.4
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.3	-0.3	-0.2	0.1	-0.0	0.3
Extinction: sum of active levers before priming	0.9	0.9	2.2	1.3	-1.3	-1.5	-0.3	-0.2	0.3
Active lever presses in extinction session 6	0.6	0.6	1.4	1.2	-1.0	-0.8	-0.5	-0.2	-0.2
Delta distance traveled before/after self-admin	0.3	0.3	0.8	0.2	-0.6	-0.9	-0.4	0.3	0.7
Delta ambulatory time before/after self-admin	0.7	0.8	2.3	0.6	-1.2	-1.5	-0.5	0.1	0.7
Time in closed arm before self-admin	2.8	3.2	4.3	1.8	-2.0	-2.1	-1.9	1.9	0.4
Time in closed arm after self-admin	0.4	0.4	0.9	0.2	-0.7	-0.5	-0.9	1.0	0.4
Time in open arm before self-admin	3.0	3.2	4.2	-1.3	2.0	2.0	1.8	-1.9	-1.5
Time in open arm after self-admin	1.8	2.0	3.0	-0.8	1.5	1.4	1.7	-1.7	-1.1
Sum of active levers in priming session hrs 5-6	2.3	2.2	4.8	2.2	-1.7	-1.9	-1.1	0.2	-0.9
Time to tail flick, vehicle, before self-admin	1.6	1.6	2.4	1.5	-1.6	-1.4	-1.4	0.9	0.2
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.0	-0.0	0.1	0.2	-0.9	1.0	-0.1
Time to tail flick, test, before self-admin	0.5	0.5	1.6	-0.6	0.4	0.3	-0.6	1.3	0.4
Time to tail flick, test, after self-admin	0.3	0.4	1.0	-1.0	0.1	0.4	0.2	0.1	0.9
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.8	0.8	0.6	0.1	0.3	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.2	-0.5	-0.2	0.3	-0.5	0.2
Ambulatory time before self-admin	4.0	4.2	6.4	-1.6	2.5	2.4	2.1	-1.7	-1.6
Ambulatory time after self-admin	0.6	0.6	1.0	-0.8	0.9	0.6	1.0	-0.9	-0.4
Total heroin consumption	0.5	0.6	1.2	1.1	-0.2	-0.2	-1.1	0.6	-0.6
Area under the delay curve	0.5	0.6	1.5	0.9	-0.6	-0.5	0.4	-1.2	-0.6
Delay disc. indifference point, 0s delay	0.9	1.0	2.0	1.4	-1.0	-1.0	-1.1	0.5	-0.5
Delay disc. indifference point, 16s delay	1.2	1.2	2.0	1.4	-0.6	-0.6	0.7	-1.4	-1.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.4	-0.0	0.0	-0.4	0.3	0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	-0.5	-0.3	0.0	-0.4	-0.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	0.2	-0.4	-0.2	0.3	-0.8	0.2
Delay disc. indifference point, 8s delay	0.7	0.7	2.7	-0.1	-0.0	0.2	1.2	-1.7	-0.1
Delay discount exponential model param	0.5	0.5	1.5	-0.8	0.5	0.3	-0.5	1.2	0.5
Delay discount hyperbolic model param	0.4	0.4	1.4	-0.7	0.5	0.3	-0.4	1.2	0.5
Fecal boli incidents, locomotor time 1	0.7	0.8	1.8	1.0	-1.3	-1.3	-0.2	-0.3	0.1
Change in fecal boli incidents, locomotor task	1.8	1.7	2.9	-0.8	1.3	1.3	1.7	-1.6	-0.8
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.3	0.3	0.4	0.5	1.2	-1.5	-0.6
Bouts of movement, locomotor time 1	1.0	1.1	2.4	1.2	-1.4	-1.6	-0.2	-0.4	0.5
Total resting periods, locomotor time 1	1.4	1.6	3.6	1.3	-1.7	-1.9	-0.4	-0.2	1.1
Rest time, locomotor task time 1	2.0	2.2	4.8	0.2	-1.8	-1.9	-0.9	0.6	2.2
Distance moved, locomotor task time 1	1.9	2.1	4.2	-0.7	2.0	2.1	0.7	-0.5	-1.8
Vertical activity count, locomotor time 1	1.3	1.3	2.6	-0.0	1.6	1.5	0.7	-0.6	-1.5
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.2	-0.2	0.3	0.4	1.1	-1.1	-0.6
Bouts of movement, locomotor time 2	1.3	1.4	4.1	-0.9	0.8	0.7	2.0	-1.6	0.2
Total resting periods, locomotor time 2	0.8	0.9	2.7	-0.6	0.5	0.3	1.6	-1.3	0.3
Rest time, locomotor task time 2	0.6	0.7	1.7	0.7	-1.0	-1.3	-0.6	-0.0	0.6
Distance moved, locomotor task time 2	0.6	0.7	1.9	-0.9	0.6	0.8	-0.8	1.4	0.4
Vertical activity count, locomotor time 2	0.3	0.3	0.9	-0.4	0.8	0.9	-0.2	0.5	-0.2
Weight adjusted by age	1.1	1.2	3.0	0.4	0.5	0.6	1.1	-1.5	-1.7
Seeking ratio, delayed vs. immediate footshock	2.1	2.5	4.5	-2.1	1.9	2.1	1.4	-0.4	0.0
Locomotion in novel chamber	0.2	0.3	0.5	-0.1	-0.5	-0.6	0.7	-0.7	0.5
Locomotion in novel chamber post-restriction	1.5	1.7	3.5	-1.9	0.9	0.9	1.6	-0.9	1.4
Progressive ratio	0.5	0.6	1.9	0.4	-0.2	-0.1	-1.0	1.4	-0.6
Food seeking constrained by brief footshock	6.2	7.6	12.6	-2.3	3.6	3.5	2.9	-1.9	-1.8
Seeking ratio, punishment vs. effort	2.7	3.3	5.6	-1.6	2.0	1.7	2.4	-2.2	-0.4
Run reversals in cocaine runway, females	0.5	0.5	1.5	-0.1	-0.5	-0.3	-0.9	1.2	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.1	-0.2	-0.2	-0.5	0.6	0.3
Latency to leave start box in cocaine runway	0.6	0.7	1.3	-1.1	0.9	1.1	0.6	-0.3	-0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	0.1	0.0	0.3	-0.2	0.1	-0.7
Latency to leave start box in cocaine runway, M	1.5	1.4	2.5	-1.1	1.6	1.5	1.3	-0.9	-0.5
Cd content in liver	0.6	0.6	1.3	-1.2	0.7	0.8	0.3	0.3	1.1
Co content in liver	1.0	1.1	2.2	1.4	-0.9	-1.0	-1.5	0.6	-0.8
Cu content in liver	1.9	2.3	4.9	0.6	-1.2	-1.2	-2.2	2.2	1.0
Fe content in liver	0.9	1.0	4.3	0.5	0.9	0.7	0.1	-0.7	-2.1
K content in liver	0.4	0.4	1.0	0.8	-0.3	-0.3	0.2	-1.0	-0.7
Mg content in liver	0.5	0.5	1.1	1.0	-0.9	-0.9	-0.7	-0.2	-0.1
Mn content in liver	0.3	0.3	1.1	-0.6	0.2	0.1	0.3	-0.4	1.1
Na content in liver	1.6	1.7	4.0	1.1	-1.1	-1.2	-2.0	1.6	0.2
Rb content in liver	2.2	2.8	5.8	2.4	-2.2	-2.3	-1.1	0.1	-0.3
Se content in liver	1.2	1.4	3.2	-1.8	1.3	1.4	0.6	0.1	1.0
Sr content in liver	0.7	0.7	1.2	-0.6	0.6	0.7	1.1	-1.1	0.6
Zn content in liver	0.3	0.3	1.1	-0.5	-0.2	-0.0	-0.4	0.4	1.1