Hub : Genes

Pou3f3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000038909	0.24	0.11	1.4e-15	0.18	0.17	0.18	0.18	2.0e-16	9.9e-16	1.8e-16	1.8e-16
2	Brain	mRNA stability	ENSRNOG00000038909	0.03	0.02	5.5e-03	0.01	0.01	0	0.01	4.0e-02	2.0e-02	1.7e-01	5.9e-02
3	NAcc	mRNA stability	ENSRNOG00000038909	0.04	0.03	1.2e-03	0.05	0.04	0.03	0.03	2.2e-04	1.1e-03	3.0e-03	1.3e-03
4	PL	gene expression	ENSRNOG00000038909	0.15	0.07	2.2e-08	0.12	0.1	0.1	0.11	4.9e-09	3.1e-08	2.4e-08	1.9e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	1.1	3.5	7.0	-0.7	2.6	2.6	-0.5
BMI without tail	0.0	0.0	0.0	0.0	-0.2	-0.1	0.2
Body weight	0.0	0.1	0.2	0.4	0.3	0.2	0.3
Epididymis fat weight	0.1	0.2	0.3	-0.3	0.4	0.5	-0.5
Glucose	0.3	0.5	0.9	-0.9	-0.6	-0.2	-0.8
Heart weight	0.8	1.1	1.8	-1.0	1.0	1.3	-0.9
Left kidney weight	0.1	0.2	0.5	0.7	0.3	0.5	0.3
Right kidney weight	0.9	2.5	5.5	2.3	-0.3	-0.2	2.1
Tail length	0.5	1.5	2.9	-0.0	-1.7	-1.7	0.0
Length with tail	0.3	1.0	1.8	0.7	-1.2	-1.3	0.5
Length without tail	0.3	0.7	1.3	0.8	1.1	0.7	0.6
Liver weight, left	0.2	0.4	0.5	0.7	-0.5	-0.6	0.6
Liver weight, right	0.1	0.2	0.4	0.0	-0.6	-0.5	-0.4
Parametrial fat weight	0.0	0.0	0.1	0.1	-0.2	0.0	0.4
Retroperitoneal fat weight	0.2	0.8	1.2	1.0	0.7	0.6	1.1
Intraocular pressure	1.0	1.4	2.4	-0.7	1.5	1.5	-0.7
Extensor digitorum longus weight	3.9	15.5	32.2	-0.9	5.7	5.4	-0.6
Soleus weight	0.7	2.0	4.1	0.3	2.0	1.9	0.5
Tibialis anterior weight	1.9	6.7	13.7	-0.5	3.7	3.6	-0.4
Tibia length	0.8	2.1	2.5	1.5	-1.3	-1.6	1.4
Number of licking bursts	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.4
Food consumed during 24 hour testing period	0.4	0.4	0.8	-0.5	0.8	0.9	-0.3
Times rat made contact with spout	1.0	1.1	1.9	-1.3	-0.7	-0.6	-1.4
Mean time between licks in bursts	0.9	1.2	2.2	0.4	1.5	1.4	0.8
Mean num. licks in bursts	0.2	0.2	0.3	-0.5	0.3	0.4	-0.5
Std. dev. time between licks in bursts	0.3	0.3	0.7	-0.4	0.8	0.7	-0.2
Water consumed over 24 hours	0.2	0.2	0.4	-0.6	0.2	0.3	-0.6
Indifference point 0 sec	0.4	0.6	1.3	1.1	0.6	0.3	0.7
Indifference point AUC	0.7	0.8	1.0	-0.8	0.8	1.0	-0.9
Indifference point function ln k	0.4	0.6	1.4	-0.0	1.2	0.9	0.2
Indifference point function log k	0.4	0.6	1.4	-0.0	1.2	0.9	0.2
Delay discounting total patch changes 0 sec	0.2	0.3	0.5	0.7	0.7	0.4	0.3
Delay discounting total patch changes 12 sec	0.6	0.8	2.1	1.4	-0.3	-0.5	1.0
Delay discounting total patch changes 18 sec	0.7	0.9	1.1	-0.6	1.0	1.1	-1.0
Delay discounting total patch changes 24 sec	0.3	0.4	0.8	0.9	0.3	0.3	0.7
Delay discounting total patch changes 6 sec	0.1	0.1	0.2	0.4	0.3	0.2	-0.2
Delay discounting time to switch 0 sec	0.5	0.8	1.0	0.8	-1.0	-0.9	0.8
Delay discounting water rate 0 sec	0.8	1.2	2.3	-1.2	0.8	0.7	-1.5
Delay discounting water rate 12 sec	0.4	0.6	0.9	-1.0	0.5	0.6	-0.9
Delay discounting water rate 18 sec	0.1	0.1	0.2	-0.1	0.1	-0.2	-0.4
Delay discounting water rate 24 sec	0.2	0.2	0.3	-0.5	0.6	0.2	-0.5
Delay discounting water rate 6 sec	0.8	1.1	1.5	-1.2	0.8	0.9	-1.2
Locomotor activity	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.3
Locomotor testing distance	0.6	1.1	2.1	0.5	-1.5	-1.4	0.2
Locomotor testing rearing	1.3	2.0	3.0	1.3	-1.6	-1.7	0.9
Light reinforcement 1	1.3	2.3	5.0	0.1	2.2	2.1	0.2
Light reinforcement 2	0.4	0.5	1.0	-0.2	1.0	1.0	-0.2
Reaction time number correct	0.6	0.8	1.9	-0.2	1.4	1.2	0.1
Reaction time mean minus median	0.5	0.7	1.3	-0.1	-1.1	-1.1	-0.5
Reaction time mean minus median AUC	0.4	0.5	1.1	-0.0	-0.9	-1.0	-0.3
Reaction time num false alarms	1.2	1.6	3.1	-0.5	1.6	1.8	-0.7
Reaction time num false alarms AUC	1.3	1.9	3.6	-0.3	1.9	1.9	-0.5
Reaction time trials correct on left	0.6	0.8	1.9	-0.2	1.4	1.2	0.1
Reaction time trials on left	0.5	0.8	1.7	-0.2	1.3	1.1	0.1
Reaction time mean	1.2	1.6	3.2	-0.2	-1.8	-1.8	-0.4
Reaction time mean AUC	0.9	1.2	2.2	-0.4	-1.5	-1.5	-0.5
Median of all reaction times	1.1	1.4	2.8	-0.3	-1.7	-1.6	-0.4
Reaction time omissions	0.5	0.7	1.1	0.5	-1.0	-1.1	0.6
Reaction time false alarm rate	0.4	0.6	1.2	-0.0	1.0	1.1	-0.4
Reaction time premature initiation rate	0.1	0.1	0.3	0.1	-0.4	-0.6	-0.1
Reaction time premature initiations	0.0	0.0	0.0	0.0	0.2	-0.0	-0.1
Std. dev. reaction times	0.8	1.1	2.2	0.2	-1.5	-1.4	-0.1
Reaction time trials completed	0.5	0.8	1.7	-0.2	1.3	1.1	0.1
Reaction time trials AUC	0.5	0.7	1.6	-0.2	1.3	1.1	0.1
Social response proportion	0.2	0.2	0.5	-0.5	-0.7	-0.0	-0.3
Social responses	0.5	0.7	1.5	-0.4	-1.2	-1.0	-0.2
Social time	2.9	3.8	7.2	0.8	-2.7	-2.6	0.6
Conditioned locomotion	0.6	0.7	1.4	-0.4	-1.2	-1.0	-0.5
Cocaine response after cond. corrected	1.0	1.1	2.0	-1.4	0.7	0.8	-1.2
Cocaine response after cond. not corrected	0.6	0.7	1.0	-0.9	0.6	0.7	-1.0
Cocaine response before conditioning	0.4	0.5	1.4	1.2	0.2	-0.0	0.6
Saline control response	0.4	0.6	1.3	1.2	0.2	-0.3	1.0
Condit. Reinf. active minus inactive responses	0.4	0.5	1.0	-1.0	-0.4	-0.3	-1.0
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.6	-0.7	-1.3	-0.9	-0.8
Condit. Reinf. active responses	0.3	0.5	0.8	-0.9	0.4	0.3	-0.9
Condit. Reinf. inactive responses	0.6	0.7	1.8	0.2	1.3	1.0	0.4
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.2	-0.3	-0.4	-0.6
Condit. Reinf. lever reinforcers received	0.6	0.8	1.4	-1.1	0.6	0.5	-1.2
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.4	0.5	0.5	-0.0
Pavlov. Cond. magazine entry latency	0.8	0.9	1.9	1.4	-0.3	-0.4	1.1
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	0.3	-0.7	-0.9	0.1
Pavlov. Cond. index score	0.2	0.3	0.3	0.6	-0.6	-0.6	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.5	-0.3	-0.3	0.2
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.5	-0.8	-0.9	0.1
Pavlov. Cond. magazine entry number	0.5	0.6	1.0	-1.0	0.7	0.7	-0.8
Pavlov. Cond. intertrial magazine entries	2.5	3.3	5.0	-1.4	2.1	2.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	0.7	-0.4	-0.5	0.4
Pavlov. Cond. response bias	0.9	1.3	1.9	1.4	-1.0	-1.1	1.0
Conditioned reinforcement - actives	0.7	0.7	1.0	-1.0	0.2	0.9	-1.0
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.0	-0.2	0.2	0.1
Conditioned locomotion	0.4	0.5	1.5	-0.1	0.7	1.2	-0.0
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.3	-0.1	0.2	0.4
Intermittent access intake escalation	0.1	0.1	0.2	0.4	-0.5	-0.3	0.4
Intermittent access intake escalation 2	0.1	0.1	0.2	0.1	-0.5	-0.3	0.1
Intermitt. access day 1 inactive lever presses	0.8	0.9	1.2	0.8	-1.0	-1.1	0.8
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	0.9	-0.3	-0.2	0.8
Intermitt. access escalation Index	0.1	0.1	0.3	0.3	0.1	-0.3	0.6
Intermittent access day 1 total infusions	1.9	2.1	3.8	-2.0	-0.1	0.9	-1.9
Intermittent access day 15 total infusions	0.7	0.8	1.5	-1.2	-0.4	0.6	-1.1
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.9	-1.4	-0.0	1.1	-1.3
Intermittent access total infusions	1.5	1.6	3.0	-1.7	-0.2	1.0	-1.6
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.4	-0.0	0.5	-0.2
Intermittent access day 15 total locomotion	0.2	0.2	0.6	-0.3	0.3	0.8	-0.2
Intermittent access total locomotion	0.3	0.3	0.7	-0.5	0.4	0.9	-0.3
Intermittent access standard deviation	0.8	0.9	2.5	-0.4	-1.6	-0.7	-0.6
Cocaine induced anxiety	1.6	1.8	3.0	0.9	1.7	1.7	0.7
Post-drug Anxiety	0.8	0.9	1.9	-0.2	1.4	1.2	-0.3
Baseline Anxiety	1.7	1.8	3.1	-1.6	-0.8	-0.9	-1.8
Lifetime Intake	1.5	1.7	2.8	-1.7	0.0	1.2	-1.6
Incentive Sensitization - Responses	0.7	0.7	1.3	1.0	-0.1	-0.6	1.1
Incentive Sensitization - Breakpoint	0.8	0.8	1.7	1.1	0.0	-0.4	1.3
Progressive ratio test 1 active lever presses	1.6	1.7	3.3	-1.1	0.9	1.8	-1.2
Progressive ratio test 1 breakpoint	1.5	1.6	3.0	-1.1	0.8	1.7	-1.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.6	0.8	-0.7	-0.2	0.6
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.1	0.2	0.4	0.1
Progressive ratio test 2 breakpoint	0.3	0.3	0.7	-0.3	0.7	0.8	0.0
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.0	0.8	-0.5	-0.1	1.0
Total sessions with >9 infusions	2.2	2.4	4.6	-1.3	1.3	2.1	-1.2
Short access day 1 total inactive lever presses	0.5	0.6	1.1	1.1	-0.1	0.4	1.0
Short access day 10 total inactive lever presses	1.4	1.5	1.9	1.4	-0.9	-1.3	1.4
Short access day 1 total infusions	0.6	0.6	1.9	-0.2	0.6	1.4	-0.4
Short access day 10 total infusions	4.1	4.5	7.5	-2.7	0.4	1.8	-2.7
Short access total infusions	1.8	2.0	2.9	-1.5	0.5	1.7	-1.6
Short access day 1 locomotion	0.6	0.6	1.7	-0.6	0.5	1.3	-0.3
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.0
Short access total locomotion	0.4	0.4	1.1	-0.2	0.6	1.1	0.1
Compulsive drug intake	0.2	0.2	0.7	0.0	-0.4	-0.8	0.1
One hour access (0.3 mA shock)	2.1	2.4	4.9	-2.2	-1.0	-0.3	-2.0
One hour access (shock baseline)	1.3	1.5	3.1	-1.8	-0.6	0.2	-1.6
Number of responses in last shaping day	0.2	0.2	0.3	0.3	-0.6	-0.5	0.2
Context. condit. distance diff. score	1.5	1.8	2.4	1.2	-1.3	-1.5	1.3
Locomotion velocity, session 1	0.0	0.0	0.0	-0.2	0.0	0.0	0.1
Locomotion distance, session 1	0.6	0.8	1.6	0.3	1.3	1.2	0.4
Locomotion velocity, session 2	1.8	2.1	4.8	-0.1	2.2	1.9	0.1
Locomotion distance, session 2	1.5	2.1	4.1	-0.6	2.0	1.9	-0.5
Locomotion velocity, session 3	0.3	0.3	0.7	0.8	-0.2	-0.5	0.5
Locomotion distance, session 3	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.0
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	-0.2	-0.6	-0.7	-0.3
Stereotopy head waving duration, day 3	0.1	0.2	0.3	-0.5	-0.3	-0.3	-0.6
Locomotion velocity, session 7	1.3	1.4	2.0	1.2	1.3	0.9	1.4
Locomotion distance, session 7	0.6	0.7	1.4	0.2	1.2	1.0	0.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.0	-0.2	-0.5	-0.1
Stereotopy head waving duration, day 7	0.5	0.6	0.9	1.0	-0.4	-0.7	0.8
Locomotion velocity, session 8	1.6	1.9	4.0	1.8	-0.1	-0.4	2.0
Locomotion distance, session 8	0.8	1.2	2.7	1.3	0.5	0.1	1.6
Degree of sensitization distance	1.2	1.2	2.1	-0.8	1.4	1.4	-0.1
Degree of sensitization stereotypy	0.2	0.2	0.3	0.6	-0.4	-0.5	0.5
Condit. Reinf. active minus inactive responses	1.1	1.2	2.2	-1.5	0.5	0.6	-1.5
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.8	-1.3	0.2	0.3	-1.3
Condit. Reinf. active responses	0.3	0.4	0.7	-0.8	0.5	0.4	-0.7
Condit. Reinf. inactive responses	0.3	0.4	0.8	0.0	0.9	0.7	0.2
Incentive salience index mean	0.1	0.1	0.3	-0.5	0.0	-0.1	-0.5
Condit. Reinf. lever presses	0.7	1.0	1.3	1.2	-0.8	-1.0	1.0
Time in familiar zone, hab. session 1	1.1	1.0	2.1	-1.2	-0.6	-0.4	-1.5
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.1	-0.5	-0.4	0.3
Total zone transitions, hab. session 1	1.3	1.9	3.8	1.9	0.1	-0.2	2.0
Total locomotion distance, hab. session 1	0.4	0.6	1.4	0.3	1.2	1.0	0.3
Locomotion velocity, hab. session 1	0.5	0.8	1.2	0.8	1.1	0.8	0.8
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.1	-0.6	-0.6	-0.4
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1
Total zone transitions, hab. session 2	0.1	0.2	0.4	-0.2	0.4	0.6	-0.2
Total locomotion distance, hab. session 2	1.6	2.1	2.7	-1.2	1.6	1.6	-1.3
Locomotion velocity, hab. session 2	1.2	1.6	2.4	-0.9	1.5	1.6	-0.9
Novel to familiar place preference ratio	1.1	1.1	2.6	-1.6	-0.2	-0.0	-1.4
Novelty place preference	1.0	1.0	2.4	-1.5	-0.3	-0.1	-1.3
Time in novel zone, NPP test	1.2	1.2	2.6	-1.6	-0.5	-0.3	-1.4
Total zone transitions, NPP test	0.3	0.5	1.0	0.2	1.0	0.9	0.2
Total locomotion distance, NPP test	0.8	1.1	2.1	-0.5	1.4	1.2	-0.6
Locomotion velocity, NPP test	0.9	1.3	3.0	-0.2	1.7	1.5	-0.2
Pavlov. Cond. lever latency	1.0	1.3	1.7	-1.3	0.9	1.2	-1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.0	-0.3	-0.3	-0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.1	0.0	-0.1
Pavlov. Cond. index score	0.3	0.4	0.8	0.3	-0.8	-0.9	0.0
Pavlov. Cond. latency score	0.5	0.6	1.1	0.5	-0.9	-1.1	0.3
Pavlov. Cond. lever contacts	0.6	0.7	0.8	0.9	-0.7	-0.9	0.7
Pavlov. Cond. magazine entry number	0.5	0.6	1.1	0.2	1.0	0.9	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.7	0.7	0.5	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.0	-0.5	-0.6	-0.2
Pavlov. Cond. response bias	0.2	0.2	0.5	0.2	-0.6	-0.7	-0.0
Bone: apparent density	3.5	5.8	10.7	1.6	-3.0	-3.3	1.0
Bone surface	0.7	1.2	2.3	0.9	-1.1	-1.5	0.5
Bone volume	2.0	3.3	6.4	1.2	-2.2	-2.5	0.8
Bone: connectivity density	0.9	1.4	3.1	0.6	-1.5	-1.8	0.1
Bone: cortical apparent density	2.0	2.6	4.6	1.0	2.2	1.8	1.2
Bone: cortical area	0.1	0.1	0.3	0.6	-0.0	-0.3	0.4
Bone: cortical porosity	0.8	0.8	1.6	0.6	-1.1	-1.3	0.4
Bone: cortical porosity	1.4	1.5	2.3	1.1	-1.3	-1.5	1.0
Bone: cortical thickness	0.2	0.3	0.6	0.8	0.0	-0.4	0.6
Bone: cortical thickness	0.2	0.2	0.4	0.5	-0.2	-0.4	0.6
Bone: cortical tissue density	2.0	2.6	4.5	1.0	2.1	1.8	1.3
Bone: elastic displacement	0.4	0.4	0.7	-0.8	-0.6	-0.5	-0.7
Bone: elastic work	0.5	0.7	1.2	0.1	-1.1	-1.1	0.5
Bone: endosteal estimation	0.0	0.1	0.2	-0.1	-0.4	-0.3	-0.1
Bone: endosteal perimeter	0.0	0.1	0.1	-0.1	-0.3	-0.2	-0.3
Bone: final force	0.4	0.7	1.4	1.2	-0.0	-0.3	1.1
Bone: final moment	0.3	0.6	1.2	1.1	0.0	-0.3	1.0
Bone: marrow area	0.0	0.0	0.1	-0.1	-0.4	-0.3	-0.1
Bone: maximum diameter	0.2	0.3	0.5	0.4	-0.6	-0.7	0.2
Bone: maximum force	0.3	0.5	1.0	1.0	-0.1	-0.4	1.0
Bone: maximum moment	0.3	0.5	0.9	0.9	-0.0	-0.3	0.9
Bone: minimum diameter	0.1	0.2	0.3	0.6	0.4	0.2	0.5
Bone: periosteal estimation	0.1	0.3	0.5	0.5	-0.6	-0.7	0.3
Bone: periosteal perimeter	0.1	0.1	0.3	-0.2	-0.3	-0.4	-0.5
Bone: post-yield work	0.9	1.2	2.3	1.5	-0.5	-0.7	1.3
Bone: stiffness	0.7	1.0	2.2	1.5	0.0	-0.1	1.4
Bone: tissue strength	0.1	0.1	0.3	0.2	0.5	0.3	0.3
Bone: trabecular number	3.4	5.3	9.0	1.7	-2.7	-3.0	1.3
Bone: trabecular spacing	1.5	2.0	4.1	-0.5	1.9	2.0	-0.3
Bone: trabecular thickness	3.3	4.0	8.0	0.8	-2.6	-2.8	0.6
Bone: trabecular tissue density	0.3	0.4	0.8	0.9	0.0	0.0	0.8
Breakpoint value in progressive ratio session	0.3	0.3	0.5	-0.3	-0.7	-0.6	-0.4
Distance traveled before self-admin	0.5	0.5	0.7	0.6	-0.9	-0.6	0.8
Distance traveled after self-admin	3.2	3.5	4.4	2.1	-2.0	-1.8	1.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.2
Delta time in open arm before/after self-admin	0.6	0.5	1.1	0.3	-0.9	-1.1	0.4
Diff in mean of infusions in LGA sessions	0.6	0.7	1.3	-0.4	-1.1	-1.1	-0.4
Extinction: sum of active levers before priming	1.1	1.1	2.9	-0.2	-1.7	-1.3	-0.3
Active lever presses in extinction session 6	2.5	2.4	3.8	-2.0	0.6	1.3	-1.9
Delta distance traveled before/after self-admin	0.5	0.5	1.2	1.1	-0.4	-0.6	0.7
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	0.9	-0.2	-0.2	0.5
Time in closed arm before self-admin	1.0	1.2	2.1	-1.4	-0.8	-0.4	-1.5
Time in closed arm after self-admin	0.3	0.3	0.7	0.1	-0.8	-0.7	-0.0
Time in open arm before self-admin	0.7	0.8	1.8	-0.1	1.1	1.3	-0.2
Time in open arm after self-admin	0.4	0.5	0.6	0.6	-0.7	-0.7	0.8
Sum of active levers in priming session hrs 5-6	1.4	1.4	2.6	-1.6	-0.5	-0.3	-1.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.1	-0.4	-0.4	0.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.3	-0.2	-0.5	-0.1
Time to tail flick, test, before self-admin	2.3	2.3	3.5	-1.2	1.7	1.9	-1.1
Time to tail flick, test, after self-admin	1.0	1.0	1.7	-0.9	1.0	1.3	-0.7
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.1	0.3	0.2	0.1
Delta time to tail flick, test, before/after SA	0.4	0.4	0.9	-0.0	-1.0	-0.8	0.0
Ambulatory time before self-admin	0.2	0.2	0.5	0.3	-0.5	-0.2	0.7
Ambulatory time after self-admin	1.1	1.2	2.7	1.7	-0.7	-0.3	1.3
Total heroin consumption	1.0	1.2	2.3	-1.4	-0.6	-0.2	-1.5
Area under the delay curve	2.1	2.3	4.1	-2.0	0.6	1.0	-1.9
Delay disc. indifference point, 0s delay	0.6	0.6	0.9	0.6	0.8	1.0	0.6
Delay disc. indifference point, 16s delay	1.3	1.3	2.6	-1.6	-0.5	-0.2	-1.5
Delay disc. indifference point, 2s delay	1.0	1.1	1.5	-1.2	0.5	1.0	-1.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.5	0.0	0.2	-0.5
Delay disc. indifference point, 4s delay	0.4	0.4	0.9	-0.4	0.7	1.0	-0.2
Delay disc. indifference point, 8s delay	1.4	1.4	2.6	-1.6	0.4	0.6	-1.6
Delay discount exponential model param	2.1	2.2	4.1	2.0	-0.5	-1.0	1.9
Delay discount hyperbolic model param	2.1	2.3	3.7	1.9	-0.8	-1.2	1.8
Fecal boli incidents, locomotor time 1	1.1	1.2	1.5	-0.8	1.2	1.2	-1.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	0.5	-0.6	-0.7	0.3
Time >=10cm from walls, locomotor time 1	2.2	2.2	4.6	-0.6	2.1	2.0	-0.3
Bouts of movement, locomotor time 1	7.3	8.1	9.1	-2.9	2.7	2.7	-3.0
Total resting periods, locomotor time 1	6.4	7.1	7.4	-2.6	2.7	2.7	-2.7
Rest time, locomotor task time 1	1.9	2.1	4.4	-1.9	0.1	0.5	-2.1
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.2	0.7	0.6	0.4
Vertical activity count, locomotor time 1	1.1	1.1	1.7	1.3	-0.5	-0.9	1.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.3	-0.1	0.0	-0.3
Bouts of movement, locomotor time 2	1.9	2.1	3.1	-1.1	1.4	1.8	-1.4
Total resting periods, locomotor time 2	1.7	1.8	3.0	-1.0	1.3	1.7	-1.3
Rest time, locomotor task time 2	0.2	0.3	0.6	-0.5	-0.4	-0.3	-0.8
Distance moved, locomotor task time 2	0.8	0.9	1.6	-0.5	1.3	1.3	-0.3
Vertical activity count, locomotor time 2	0.2	0.2	0.3	0.6	0.5	0.3	0.5
Weight adjusted by age	1.1	1.3	1.8	1.3	1.0	0.8	1.3
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.5	0.5	-1.2	-0.8	0.5
Locomotion in novel chamber	3.2	3.9	7.5	-0.7	2.7	2.7	-0.6
Locomotion in novel chamber post-restriction	1.0	1.2	2.4	-0.2	1.5	1.6	-0.1
Progressive ratio	2.6	3.0	4.1	-2.0	1.3	1.7	-1.8
Food seeking constrained by brief footshock	0.5	0.6	0.7	-0.8	0.6	0.8	-0.9
Seeking ratio, punishment vs. effort	0.7	0.8	1.2	1.1	-0.8	-0.9	0.9
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.3	0.8	0.8	0.2
Run reversals in cocaine runway, males	0.3	0.3	0.4	-0.5	0.4	0.6	-0.6
Latency to leave start box in cocaine runway	1.1	1.2	1.3	1.0	1.1	1.1	1.1
Latency to leave start box in cocaine runway, F	1.2	1.3	2.8	1.7	0.1	-0.1	1.6
Latency to leave start box in cocaine runway, M	2.6	2.5	5.0	-0.8	2.0	2.2	-0.6
Cd content in liver	0.4	0.4	0.6	0.7	-0.5	-0.6	0.8
Co content in liver	0.1	0.2	0.3	0.1	-0.5	-0.5	0.2
Cu content in liver	0.2	0.2	0.5	0.2	-0.7	-0.7	0.1
Fe content in liver	2.8	3.3	5.5	1.3	-2.3	-2.3	1.1
K content in liver	0.4	0.4	0.6	0.5	0.8	0.6	0.5
Mg content in liver	0.3	0.3	0.6	0.8	0.2	-0.0	0.8
Mn content in liver	0.3	0.3	0.7	0.1	0.6	0.8	0.5
Na content in liver	1.9	2.1	2.9	1.7	-1.1	-1.2	1.6
Rb content in liver	1.8	2.2	3.6	-1.1	1.7	1.9	-1.1
Se content in liver	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2
Sr content in liver	0.6	0.6	1.0	-1.0	0.5	0.6	-0.8
Zn content in liver	0.0	0.0	0.1	0.2	0.3	0.0	0.1