Hub : Genes

ENSRNOG00000038766

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS ENSRNOT00000059225 0.06 0.03 4.5e-04 0.04 0.03 0.01 0.02 2.5e-04 1.7e-03 5.2e-02 3.2e-03
2 Brain alternative TSS ENSRNOT00000097735 0.07 0.03 3.8e-04 0.04 0.03 0.01 0.02 2.2e-04 1.6e-03 4.9e-02 2.7e-03
3 Brain gene expression ENSRNOG00000038766 0.08 0.04 5.1e-05 0.04 0.05 0.06 0.06 2.5e-04 1.4e-05 7.6e-06 5.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.41.42.8-0.80.8-1.7
BMI without tail0.61.32.9-0.80.8-1.7
Body weight2.510.612.9-3.13.1-3.6
Epididymis fat weight1.84.25.2-2.32.3-1.5
Glucose0.30.50.70.8-0.80.1
Heart weight1.21.72.1-1.41.4-0.9
Left kidney weight9.226.327.2-5.15.1-5.2
Right kidney weight9.928.129.1-5.45.4-5.1
Tail length1.85.56.1-2.32.3-2.5
Length with tail2.38.69.0-2.92.9-3.0
Length without tail1.63.53.8-1.91.9-1.7
Liver weight, left4.37.09.2-3.03.0-1.6
Liver weight, right3.55.87.3-2.72.7-1.7
Parametrial fat weight1.63.13.5-1.91.9-1.5
Retroperitoneal fat weight0.00.00.1-0.20.20.0
Intraocular pressure0.30.40.6-0.80.80.3
Extensor digitorum longus weight0.31.11.3-1.01.0-1.2
Soleus weight0.00.10.10.3-0.30.3
Tibialis anterior weight1.24.14.3-2.12.1-1.9
Tibia length0.10.20.3-0.40.4-0.5
Number of licking bursts2.02.33.2-1.81.8-0.7
Food consumed during 24 hour testing period0.40.50.5-0.70.7-0.6
Times rat made contact with spout1.21.31.61.3-1.30.9
Mean time between licks in bursts0.20.30.4-0.60.6-0.5
Mean num. licks in bursts3.84.66.22.5-2.51.2
Std. dev. time between licks in bursts0.10.10.1-0.30.3-0.3
Water consumed over 24 hours0.00.00.00.2-0.20.2
Indifference point 0 sec1.11.82.5-1.61.6-0.6
Indifference point AUC0.91.11.6-1.31.30.2
Indifference point function ln k0.40.51.5-0.10.1-1.2
Indifference point function log k0.40.51.5-0.10.1-1.2
Delay discounting total patch changes 0 sec1.32.22.9-1.71.7-0.8
Delay discounting total patch changes 12 sec1.01.31.9-1.41.4-0.4
Delay discounting total patch changes 18 sec0.10.10.2-0.00.00.5
Delay discounting total patch changes 24 sec4.05.05.9-2.42.4-1.8
Delay discounting total patch changes 6 sec3.96.07.2-2.72.7-1.9
Delay discounting time to switch 0 sec0.30.50.70.8-0.80.0
Delay discounting water rate 0 sec0.81.21.8-1.31.3-0.2
Delay discounting water rate 12 sec2.43.64.6-2.12.1-1.2
Delay discounting water rate 18 sec3.54.64.9-2.22.2-2.0
Delay discounting water rate 24 sec0.20.20.70.1-0.10.8
Delay discounting water rate 6 sec3.45.07.0-2.62.6-0.9
Locomotor activity5.89.110.0-3.23.2-2.7
Locomotor testing distance2.54.15.2-2.32.3-1.4
Locomotor testing rearing2.13.34.7-2.22.2-0.8
Light reinforcement 10.10.30.4-0.60.6-0.1
Light reinforcement 20.20.20.30.4-0.40.6
Reaction time number correct0.60.91.80.6-0.61.4
Reaction time mean minus median0.60.80.8-0.90.9-0.9
Reaction time mean minus median AUC0.00.00.00.1-0.10.2
Reaction time num false alarms1.21.72.0-1.41.4-1.0
Reaction time num false alarms AUC0.71.01.3-1.11.1-0.7
Reaction time trials correct on left0.60.91.80.6-0.61.4
Reaction time trials on left0.71.02.00.7-0.71.4
Reaction time mean2.02.73.4-1.81.8-1.2
Reaction time mean AUC1.21.62.0-1.41.4-0.8
Median of all reaction times1.72.33.0-1.71.7-1.0
Reaction time omissions0.30.40.50.7-0.70.3
Reaction time false alarm rate0.81.11.3-1.11.1-0.9
Reaction time premature initiation rate3.85.16.4-2.12.1-2.5
Reaction time premature initiations1.92.72.9-1.61.6-1.7
Std. dev. reaction times1.11.61.9-1.41.4-1.0
Reaction time trials completed0.71.02.00.7-0.71.4
Reaction time trials AUC0.71.12.30.7-0.71.5
Social response proportion1.01.11.61.3-1.30.3
Social responses1.21.62.0-1.11.1-1.4
Social time0.30.40.60.8-0.8-0.1
Conditioned locomotion0.91.11.1-1.11.1-1.0
Cocaine response after cond. corrected1.82.02.81.7-1.70.7
Cocaine response after cond. not corrected1.41.52.11.5-1.50.6
Cocaine response before conditioning0.00.00.1-0.20.20.2
Saline control response2.22.93.9-2.02.0-1.0
Condit. Reinf. active minus inactive responses0.20.20.30.5-0.50.6
Condit. Reinf. active-inactive response ratio0.91.01.01.0-1.00.9
Condit. Reinf. active responses0.00.00.0-0.20.20.2
Condit. Reinf. inactive responses1.21.51.9-1.41.4-0.8
Condit. Reinf. lever presses0.20.30.4-0.60.6-0.3
Condit. Reinf. lever reinforcers received0.00.10.1-0.30.30.2
Pavlov. Cond. lever latency0.10.10.20.4-0.4-0.1
Pavlov. Cond. magazine entry latency0.30.40.4-0.60.6-0.6
Pavlov. Cond. change in total contacts0.60.91.2-1.11.1-0.4
Pavlov. Cond. index score0.40.50.7-0.80.8-0.1
Pavlov. Cond. latency score0.40.50.7-0.90.9-0.0
Pavlov. Cond. lever contacts0.20.30.4-0.60.6-0.2
Pavlov. Cond. magazine entry number0.20.30.30.6-0.60.3
Pavlov. Cond. intertrial magazine entries0.30.40.40.7-0.70.6
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.70.70.0
Pavlov. Cond. response bias0.50.70.8-0.90.9-0.6
Conditioned reinforcement - actives0.80.81.4-0.70.7-1.2
Conditioned reinforcement - inactives1.41.63.0-1.01.0-1.7
Conditioned locomotion0.20.30.6-0.30.3-0.8
Intermittent access intake day 1-15 change0.10.10.2-0.40.4-0.4
Intermittent access intake escalation0.00.00.00.1-0.10.1
Intermittent access intake escalation 20.10.10.1-0.30.3-0.3
Intermitt. access day 1 inactive lever presses0.60.60.91.0-1.0-0.0
Intermitt. access day 15 inactive lever presses0.10.20.30.3-0.3-0.6
Intermitt. access escalation Index1.00.91.01.0-1.00.8
Intermittent access day 1 total infusions4.45.05.52.3-2.32.0
Intermittent access day 15 total infusions1.11.21.61.3-1.30.7
Intermittent access terminal intake (last 3 days)1.41.52.01.4-1.40.8
Intermittent access total infusions1.71.92.61.6-1.60.7
Intermittent access day 1 locomotion1.91.92.11.5-1.51.2
Intermittent access day 15 total locomotion0.00.00.00.0-0.00.1
Intermittent access total locomotion0.80.90.90.9-0.91.0
Intermittent access standard deviation0.20.30.3-0.50.5-0.5
Cocaine induced anxiety0.00.00.00.2-0.20.1
Post-drug Anxiety0.30.40.90.4-0.40.9
Baseline Anxiety0.30.30.9-0.20.20.9
Lifetime Intake1.41.52.11.5-1.50.6
Incentive Sensitization - Responses0.40.40.50.5-0.50.7
Incentive Sensitization - Breakpoint0.30.30.40.5-0.50.7
Progressive ratio test 1 active lever presses1.31.31.81.4-1.40.6
Progressive ratio test 1 breakpoint0.91.01.41.2-1.20.4
Progressive ratio test 1 inactive lever presses0.30.30.40.7-0.7-0.2
Progressive ratio test 2 active lever presses2.12.22.71.6-1.61.1
Progressive ratio test 2 breakpoint1.01.11.41.2-1.20.7
Progressive ratio test 2 inactive lever presses2.52.93.51.9-1.91.4
Total sessions with >9 infusions0.10.20.20.5-0.50.0
Short access day 1 total inactive lever presses0.91.01.41.2-1.20.3
Short access day 10 total inactive lever presses0.10.10.30.2-0.2-0.6
Short access day 1 total infusions1.41.52.01.4-1.40.8
Short access day 10 total infusions3.03.34.12.0-2.01.2
Short access total infusions0.70.81.11.1-1.10.4
Short access day 1 locomotion0.10.10.40.0-0.0-0.6
Short access day 10 total locomotion1.41.52.51.0-1.01.6
Short access total locomotion0.10.10.2-0.20.2-0.5
Compulsive drug intake5.55.45.9-2.42.4-2.1
One hour access (0.3 mA shock)0.80.91.0-0.90.9-1.0
One hour access (shock baseline)0.40.50.70.8-0.80.4
Number of responses in last shaping day2.62.74.0-1.41.4-2.0
Context. condit. distance diff. score0.81.01.1-1.01.0-0.9
Locomotion velocity, session 10.40.40.6-0.80.8-0.1
Locomotion distance, session 10.10.10.2-0.20.20.5
Locomotion velocity, session 20.40.50.7-0.80.80.2
Locomotion distance, session 20.10.10.20.4-0.40.0
Locomotion velocity, session 31.61.93.41.1-1.11.8
Locomotion distance, session 30.10.10.10.3-0.30.4
Stereotopy head waving bouts, day 31.41.74.50.5-0.52.1
Stereotopy head waving duration, day 31.11.33.60.4-0.41.9
Locomotion velocity, session 71.81.92.01.4-1.41.4
Locomotion distance, session 70.10.10.10.3-0.3-0.3
Stereotopy head waving bouts, day 71.31.54.30.2-0.22.1
Stereotopy head waving duration, day 71.82.15.80.6-0.62.4
Locomotion velocity, session 80.10.10.2-0.20.2-0.4
Locomotion distance, session 80.40.50.6-0.80.8-0.7
Degree of sensitization distance0.30.30.8-0.30.3-0.9
Degree of sensitization stereotypy1.41.54.00.5-0.52.0
Condit. Reinf. active minus inactive responses0.91.01.31.1-1.10.7
Condit. Reinf. active-inactive response ratio0.50.60.80.9-0.90.4
Condit. Reinf. active responses0.70.91.21.1-1.10.6
Condit. Reinf. inactive responses0.10.10.20.4-0.4-0.0
Incentive salience index mean0.10.20.20.5-0.50.1
Condit. Reinf. lever presses0.10.20.3-0.30.3-0.6
Time in familiar zone, hab. session 10.50.50.6-0.80.80.5
Time in novel zone, hab. session 12.01.92.91.7-1.7-0.1
Total zone transitions, hab. session 12.53.53.6-1.91.9-1.9
Total locomotion distance, hab. session 11.31.91.9-1.31.3-1.4
Locomotion velocity, hab. session 12.73.84.3-1.91.9-2.1
Time in familiar zone, hab. session 20.50.51.00.5-0.51.0
Time in novel zone, hab. session 20.20.20.40.3-0.3-0.6
Total zone transitions, hab. session 20.50.60.9-0.90.9-0.3
Total locomotion distance, hab. session 20.10.10.2-0.30.30.4
Locomotion velocity, hab. session 20.10.20.2-0.50.50.3
Novel to familiar place preference ratio0.10.10.1-0.20.2-0.4
Novelty place preference0.10.10.2-0.30.3-0.4
Time in novel zone, NPP test0.00.10.1-0.00.0-0.4
Total zone transitions, NPP test0.91.31.5-1.21.2-1.0
Total locomotion distance, NPP test0.91.31.5-1.21.2-0.9
Locomotion velocity, NPP test0.50.71.0-1.01.0-0.4
Pavlov. Cond. lever latency0.60.80.90.9-0.90.8
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.30.1
Pavlov. Cond. change in total contacts1.71.82.5-1.61.6-0.8
Pavlov. Cond. index score0.81.01.1-1.01.0-0.9
Pavlov. Cond. latency score0.40.50.6-0.80.8-0.6
Pavlov. Cond. lever contacts0.80.91.1-1.11.1-0.8
Pavlov. Cond. magazine entry number0.00.00.00.2-0.20.1
Pavlov. Cond. intertrial magazine entries0.91.11.51.2-1.20.4
Pavlov. Cond. lever-magazine prob. diff.1.01.21.3-1.21.2-1.0
Pavlov. Cond. response bias0.70.80.9-1.01.0-0.8
Bone: apparent density0.00.10.1-0.20.20.3
Bone surface1.11.91.9-1.41.4-1.3
Bone volume0.81.41.6-1.21.2-1.0
Bone: connectivity density0.20.30.4-0.60.6-0.4
Bone: cortical apparent density0.40.50.7-0.80.8-0.3
Bone: cortical area1.01.51.8-1.11.1-1.3
Bone: cortical porosity1.01.01.40.9-0.91.2
Bone: cortical porosity0.60.60.70.8-0.80.9
Bone: cortical thickness0.00.10.1-0.30.3-0.2
Bone: cortical thickness0.00.00.00.0-0.0-0.1
Bone: cortical tissue density0.40.50.7-0.80.8-0.3
Bone: elastic displacement1.71.92.21.5-1.51.1
Bone: elastic work0.40.50.70.9-0.90.3
Bone: endosteal estimation1.94.16.3-1.71.7-2.5
Bone: endosteal perimeter1.63.25.3-1.51.5-2.3
Bone: final force0.50.81.9-0.50.5-1.4
Bone: final moment0.30.51.4-0.20.2-1.2
Bone: marrow area1.73.65.5-1.61.6-2.4
Bone: maximum diameter1.63.03.6-1.61.6-1.9
Bone: maximum force0.50.81.7-0.60.6-1.3
Bone: maximum moment0.30.51.3-0.30.3-1.1
Bone: minimum diameter2.75.05.9-2.12.1-2.4
Bone: periosteal estimation2.55.17.0-2.02.0-2.7
Bone: periosteal perimeter2.33.85.7-1.71.7-2.4
Bone: post-yield work0.40.50.6-0.80.8-0.5
Bone: stiffness0.71.12.3-0.70.7-1.5
Bone: tissue strength1.01.01.30.9-0.91.2
Bone: trabecular number0.10.10.1-0.40.40.3
Bone: trabecular spacing0.10.10.10.3-0.3-0.4
Bone: trabecular thickness0.60.71.1-1.01.0-0.1
Bone: trabecular tissue density5.57.78.4-2.92.9-2.5
Breakpoint value in progressive ratio session0.10.20.50.1-0.10.7
Distance traveled before self-admin4.24.55.9-2.42.4-1.3
Distance traveled after self-admin0.60.70.9-1.01.0-0.4
Delta time in closed arm before/after self-admin0.00.00.10.1-0.10.2
Delta time in open arm before/after self-admin1.41.31.4-1.21.2-1.1
Diff in mean of infusions in LGA sessions0.00.00.0-0.00.0-0.2
Extinction: sum of active levers before priming1.01.11.90.8-0.81.4
Active lever presses in extinction session 61.31.21.61.0-1.01.3
Delta distance traveled before/after self-admin0.70.71.11.0-1.0-0.1
Delta ambulatory time before/after self-admin1.71.82.61.6-1.60.6
Time in closed arm before self-admin0.70.81.0-1.01.0-0.5
Time in closed arm after self-admin0.00.00.1-0.00.00.4
Time in open arm before self-admin0.70.71.20.7-0.71.1
Time in open arm after self-admin0.10.10.1-0.30.3-0.3
Sum of active levers in priming session hrs 5-60.10.10.2-0.40.40.2
Time to tail flick, vehicle, before self-admin2.12.12.61.6-1.61.1
Time to tail flick, vehicle, after self-admin0.30.30.40.7-0.70.2
Time to tail flick, test, before self-admin0.10.10.2-0.40.4-0.3
Time to tail flick, test, after self-admin0.20.20.30.5-0.50.4
Delta time to tail flick, vehicle, before/after SA0.60.61.0-0.60.6-1.0
Delta time to tail flick, test, before/after SA0.00.00.00.2-0.2-0.2
Ambulatory time before self-admin1.92.02.7-1.61.6-0.8
Ambulatory time after self-admin0.10.10.2-0.50.5-0.1
Total heroin consumption0.40.41.30.2-0.21.1
Area under the delay curve0.10.10.10.3-0.30.4
Delay disc. indifference point, 0s delay1.21.31.91.0-1.01.4
Delay disc. indifference point, 16s delay0.10.10.1-0.30.30.1
Delay disc. indifference point, 2s delay0.10.10.1-0.30.3-0.2
Delay disc. indifference point, 24s delay1.81.81.8-1.31.3-1.4
Delay disc. indifference point, 4s delay2.02.12.41.4-1.41.6
Delay disc. indifference point, 8s delay0.00.00.00.0-0.0-0.2
Delay discount exponential model param0.00.00.1-0.20.2-0.1
Delay discount hyperbolic model param0.10.10.1-0.30.3-0.3
Fecal boli incidents, locomotor time 10.10.10.2-0.20.2-0.5
Change in fecal boli incidents, locomotor task1.11.01.1-1.01.0-1.0
Time >=10cm from walls, locomotor time 10.30.30.40.7-0.7-0.2
Bouts of movement, locomotor time 11.71.92.01.3-1.31.4
Total resting periods, locomotor time 12.93.23.41.8-1.81.7
Rest time, locomotor task time 13.74.14.22.0-2.01.9
Distance moved, locomotor task time 10.80.81.6-0.70.7-1.3
Vertical activity count, locomotor time 13.83.94.5-2.12.1-1.7
Time >=10cm from walls, locomotor time 22.22.33.01.7-1.71.0
Bouts of movement, locomotor time 20.00.00.1-0.10.10.4
Total resting periods, locomotor time 20.00.00.0-0.10.10.2
Rest time, locomotor task time 21.51.72.41.5-1.50.7
Distance moved, locomotor task time 20.81.01.1-1.11.1-0.8
Vertical activity count, locomotor time 22.42.63.8-1.91.9-0.5
Weight adjusted by age0.30.30.40.7-0.70.1
Seeking ratio, delayed vs. immediate footshock1.11.21.51.2-1.20.8
Locomotion in novel chamber0.10.20.2-0.50.50.2
Locomotion in novel chamber post-restriction1.11.31.6-1.31.3-0.9
Progressive ratio4.85.68.7-2.02.0-2.9
Food seeking constrained by brief footshock2.93.55.2-1.71.7-2.3
Seeking ratio, punishment vs. effort0.60.71.20.7-0.71.1
Run reversals in cocaine runway, females0.60.61.30.5-0.51.1
Run reversals in cocaine runway, males0.30.30.30.5-0.50.5
Latency to leave start box in cocaine runway0.50.61.1-0.50.5-1.0
Latency to leave start box in cocaine runway, F1.51.62.21.5-1.50.7
Latency to leave start box in cocaine runway, M10.19.710.1-3.23.2-3.0
Cd content in liver0.00.00.00.1-0.10.0
Co content in liver7.89.210.23.2-3.22.6
Cu content in liver0.20.30.40.6-0.60.4
Fe content in liver0.70.81.01.0-1.00.7
K content in liver0.10.10.30.1-0.1-0.6
Mg content in liver0.10.10.10.2-0.20.3
Mn content in liver1.01.11.41.2-1.20.8
Na content in liver0.30.40.50.7-0.70.0
Rb content in liver0.20.20.50.3-0.30.7
Se content in liver3.13.85.02.2-2.21.2
Sr content in liver1.41.31.9-1.01.0-1.4
Zn content in liver0.30.30.50.7-0.70.3