Hub : Genes

Actg1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	alternative TSS	ENSRNOT00000108340	0.07	0.05	8.3e-03	-0	0.02	-0	-0	7.7e-01	2.8e-02	3.6e-01	3.5e-01
2	Brain	gene expression	ENSRNOG00000036701	0.07	0.05	7.3e-05	0.05	0.02	0.04	0.05	9.7e-06	3.1e-03	2.6e-04	4.0e-05
3	Brain	isoform ratio	ENSRNOT00000054976	0.19	0.09	1.6e-08	0.07	0.09	0.07	0.08	6.0e-07	1.1e-08	5.2e-07	1.2e-07
4	Brain	isoform ratio	ENSRNOT00000108494	0.22	0.1	7.1e-10	0.08	0.11	0.09	0.09	3.1e-08	4.4e-10	2.5e-08	7.2e-09
5	Liver	gene expression	ENSRNOG00000036701	0.05	0.04	1.5e-05	0.03	0.04	0.04	0.04	2.1e-04	2.3e-05	8.7e-05	2.5e-05
6	Liver	isoform ratio	ENSRNOT00000054976	0.15	0.08	0.0e+00	0.16	0.17	0.17	0.17	2.4e-17	5.7e-19	1.1e-18	1.4e-18
7	Liver	isoform ratio	ENSRNOT00000108494	0.1	0.06	4.0e-12	0.09	0.1	0.09	0.1	1.2e-10	1.2e-11	3.7e-10	4.4e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.1	0.4	0.8	0.9	-0.3	-0.8	0.8	-0.6	-0.4	0.5
BMI without tail	0.9	1.9	4.0	2.0	-0.7	-1.3	1.2	-1.7	-1.2	1.4
Body weight	2.1	9.1	16.4	-0.9	-2.4	-2.6	2.5	-4.0	-3.7	3.7
Epididymis fat weight	0.3	0.6	1.5	0.5	-0.2	-0.6	0.5	-1.2	-0.9	1.0
Glucose	0.9	1.4	3.6	-1.9	-1.1	-1.1	1.3	1.0	0.6	-0.6
Heart weight	0.3	0.5	0.8	-0.2	-0.7	-0.9	0.9	-0.7	-0.6	0.6
Left kidney weight	0.3	0.9	1.8	-1.4	-0.7	-0.3	0.3	-1.1	-1.1	1.1
Right kidney weight	0.1	0.3	0.4	-0.7	0.0	0.6	-0.6	-0.5	-0.5	0.4
Tail length	2.0	6.0	13.1	-0.0	-1.9	-1.7	1.5	-3.6	-3.2	3.2
Length with tail	2.3	8.5	14.9	-2.1	-2.4	-2.1	2.0	-3.9	-3.7	3.6
Length without tail	1.0	2.2	7.5	-2.7	-1.2	-0.7	0.7	-1.2	-1.4	1.3
Liver weight, left	0.4	0.6	1.6	-1.3	-0.9	-0.8	0.8	-0.4	-0.5	0.5
Liver weight, right	1.8	2.9	5.7	-1.3	-1.4	-0.8	0.7	-2.4	-2.2	2.2
Parametrial fat weight	1.1	2.2	3.6	-0.7	-1.4	-1.3	1.2	-1.9	-1.8	1.8
Retroperitoneal fat weight	2.4	7.9	13.8	-0.6	-2.0	-2.8	2.7	-3.7	-3.3	3.4
Intraocular pressure	0.1	0.2	0.2	0.4	-0.4	-0.5	0.5	-0.4	-0.3	0.4
Extensor digitorum longus weight	0.3	1.4	4.6	2.1	1.2	0.8	-0.8	0.7	1.0	-0.9
Soleus weight	0.6	1.9	4.1	-0.5	-1.0	-0.8	0.8	-2.0	-1.8	1.8
Tibialis anterior weight	0.1	0.3	0.7	0.8	0.5	0.7	-0.8	0.2	0.3	-0.3
Tibia length	9.7	27.4	36.2	-4.0	-5.0	-4.7	4.6	-6.0	-5.9	6.0
Number of licking bursts	0.1	0.2	0.4	0.4	0.3	0.6	-0.7	-0.3	-0.1	0.1
Food consumed during 24 hour testing period	0.2	0.3	0.4	0.1	-0.4	-0.6	0.6	-0.6	-0.5	0.6
Times rat made contact with spout	2.8	3.3	3.8	-1.7	-1.9	-1.9	1.9	-1.6	-1.7	1.7
Mean time between licks in bursts	1.3	1.8	2.4	0.7	1.3	1.3	-1.3	1.5	1.5	-1.5
Mean num. licks in bursts	1.1	1.4	2.7	-1.0	-1.2	-1.6	1.6	-0.7	-0.8	0.8
Std. dev. time between licks in bursts	1.3	1.6	5.0	2.2	1.4	1.2	-1.2	0.4	0.7	-0.7
Water consumed over 24 hours	0.4	0.5	1.2	-1.1	-0.8	-0.5	0.5	-0.4	-0.6	0.5
Indifference point 0 sec	0.1	0.2	0.5	-0.0	-0.1	-0.7	0.7	-0.3	-0.3	0.3
Indifference point AUC	0.0	0.1	0.1	0.3	0.2	0.2	-0.2	0.2	0.2	-0.2
Indifference point function ln k	0.6	0.9	1.4	0.7	0.9	0.7	-0.6	1.2	1.1	-1.1
Indifference point function log k	0.6	0.9	1.4	0.7	0.9	0.7	-0.6	1.2	1.1	-1.1
Delay discounting total patch changes 0 sec	0.1	0.2	0.5	0.3	-0.0	-0.7	0.7	-0.1	-0.1	0.1
Delay discounting total patch changes 12 sec	0.1	0.2	0.4	-0.3	-0.5	-0.6	0.6	-0.2	-0.2	0.2
Delay discounting total patch changes 18 sec	0.5	0.7	1.6	1.3	0.8	0.3	-0.3	0.9	0.9	-0.9
Delay discounting total patch changes 24 sec	0.3	0.4	0.8	0.1	-0.2	-0.9	0.8	-0.7	-0.6	0.6
Delay discounting total patch changes 6 sec	0.6	0.9	1.1	-0.8	-0.7	-0.9	0.9	-1.0	-1.0	1.0
Delay discounting time to switch 0 sec	0.2	0.2	0.4	-0.1	0.4	0.5	-0.5	0.6	0.6	-0.6
Delay discounting water rate 0 sec	0.7	1.2	1.8	0.5	-0.8	-1.2	1.2	-1.3	-1.1	1.2
Delay discounting water rate 12 sec	0.3	0.4	2.1	1.5	0.5	0.2	-0.2	0.4	0.5	-0.4
Delay discounting water rate 18 sec	0.2	0.3	1.4	1.2	0.5	0.2	-0.3	-0.3	-0.0	0.1
Delay discounting water rate 24 sec	0.5	0.6	3.6	1.9	0.4	-0.5	0.4	-0.4	-0.1	0.2
Delay discounting water rate 6 sec	0.1	0.2	0.8	0.9	0.3	0.4	-0.4	0.1	0.2	-0.2
Locomotor activity	0.3	0.5	0.8	0.2	0.7	0.5	-0.4	0.9	0.8	-0.9
Locomotor testing distance	0.8	1.2	1.7	0.9	1.3	0.9	-0.9	1.2	1.2	-1.2
Locomotor testing rearing	0.5	0.7	1.1	1.0	0.9	0.6	-0.6	0.8	0.9	-0.9
Light reinforcement 1	0.2	0.4	1.3	1.2	0.4	0.2	-0.3	-0.8	-0.4	0.5
Light reinforcement 2	0.7	0.9	2.5	0.1	-0.4	-0.3	0.3	-1.6	-1.3	1.3
Reaction time number correct	3.5	4.9	12.4	3.5	2.3	2.1	-2.1	1.4	1.8	-1.7
Reaction time mean minus median	0.2	0.2	1.0	-1.0	-0.4	-0.3	0.3	-0.3	-0.4	0.4
Reaction time mean minus median AUC	0.1	0.2	0.4	-0.6	-0.2	0.3	-0.3	-0.5	-0.5	0.4
Reaction time num false alarms	0.1	0.2	0.4	0.2	0.4	0.0	-0.0	0.6	0.6	-0.6
Reaction time num false alarms AUC	0.5	0.7	1.1	0.5	0.9	0.6	-0.6	1.0	1.0	-1.0
Reaction time trials correct on left	3.5	4.9	12.4	3.5	2.3	2.1	-2.1	1.4	1.8	-1.7
Reaction time trials on left	3.6	5.1	12.8	3.6	2.4	2.1	-2.2	1.4	1.8	-1.8
Reaction time mean	0.1	0.1	0.1	0.3	-0.2	-0.3	0.2	-0.3	-0.3	0.3
Reaction time mean AUC	0.1	0.1	0.5	0.7	0.3	0.2	-0.2	-0.2	-0.0	0.1
Median of all reaction times	0.0	0.1	0.4	0.6	0.0	-0.1	0.1	-0.2	-0.1	0.1
Reaction time omissions	0.1	0.1	0.4	0.5	0.6	0.1	-0.2	-0.2	-0.1	0.1
Reaction time false alarm rate	0.3	0.4	1.7	-1.3	-0.4	-0.5	0.6	0.2	-0.0	-0.0
Reaction time premature initiation rate	0.7	1.0	2.0	0.4	0.9	0.5	-0.4	1.4	1.3	-1.3
Reaction time premature initiations	2.6	3.7	5.1	2.2	2.0	1.5	-1.5	2.0	2.1	-2.1
Std. dev. reaction times	0.2	0.3	0.4	0.4	0.5	0.6	-0.6	0.7	0.6	-0.6
Reaction time trials completed	3.6	5.1	12.8	3.6	2.4	2.1	-2.2	1.4	1.8	-1.8
Reaction time trials AUC	3.4	4.9	12.5	3.5	2.3	2.1	-2.1	1.3	1.8	-1.7
Social response proportion	0.7	0.7	0.8	0.8	0.8	0.8	-0.8	0.9	0.9	-0.9
Social responses	0.2	0.3	0.6	0.5	0.8	0.6	-0.6	0.3	0.4	-0.4
Social time	0.3	0.3	0.5	0.7	0.6	0.5	-0.5	0.5	0.6	-0.6
Conditioned locomotion	1.1	1.3	2.8	0.5	-0.7	-0.8	0.8	-1.7	-1.4	1.5
Cocaine response after cond. corrected	0.3	0.3	0.8	-0.4	-0.5	-0.9	0.9	0.2	0.0	-0.0
Cocaine response after cond. not corrected	0.1	0.2	0.4	-0.2	-0.0	-0.2	0.3	0.6	0.5	-0.5
Cocaine response before conditioning	1.1	1.4	2.4	0.6	1.2	1.5	-1.5	1.0	1.0	-1.0
Saline control response	1.8	2.4	4.2	-0.6	-1.3	-1.3	1.2	-2.0	-1.9	1.9
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	-0.1	-0.6	-0.3	0.2	-0.9	-0.8	0.8
Condit. Reinf. active-inactive response ratio	2.1	2.2	3.0	-1.1	-1.6	-1.2	1.1	-1.7	-1.7	1.7
Condit. Reinf. active responses	0.0	0.1	0.4	0.6	-0.1	0.0	-0.0	-0.0	0.0	-0.0
Condit. Reinf. inactive responses	0.8	1.0	1.5	1.2	0.8	0.6	-0.6	1.2	1.2	-1.2
Condit. Reinf. lever presses	0.2	0.2	1.3	1.1	0.2	-0.1	0.1	0.2	0.4	-0.3
Condit. Reinf. lever reinforcers received	0.1	0.2	1.1	1.0	0.1	-0.1	0.1	0.2	0.3	-0.3
Pavlov. Cond. lever latency	0.2	0.3	1.8	-1.4	-0.3	0.1	-0.1	0.0	-0.2	0.1
Pavlov. Cond. magazine entry latency	3.1	3.5	4.6	2.1	1.8	1.4	-1.4	2.1	2.1	-2.1
Pavlov. Cond. change in total contacts	0.9	1.3	3.1	1.8	1.1	0.4	-0.4	1.2	1.3	-1.2
Pavlov. Cond. index score	0.9	1.1	2.9	1.7	1.0	0.3	-0.3	1.1	1.2	-1.1
Pavlov. Cond. latency score	0.9	1.2	3.2	1.8	1.1	0.4	-0.4	1.0	1.2	-1.1
Pavlov. Cond. lever contacts	0.2	0.3	2.1	1.5	0.3	-0.0	-0.0	-0.1	0.1	-0.0
Pavlov. Cond. magazine entry number	2.5	3.1	4.4	-2.1	-1.8	-1.2	1.2	-1.9	-2.0	1.9
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.0	-0.3	-0.9	-0.7	0.6	-1.4	-1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.2	1.8	1.1	0.4	-0.4	1.2	1.4	-1.3
Pavlov. Cond. response bias	0.5	0.7	2.7	1.6	0.7	0.3	-0.3	0.6	0.8	-0.7
Conditioned reinforcement - actives	0.4	0.4	0.8	0.6	0.8	0.9	-0.9	-0.1	0.1	-0.1
Conditioned reinforcement - inactives	1.3	1.5	2.0	-0.7	-1.1	-1.2	1.2	-1.4	-1.3	1.3
Conditioned locomotion	0.1	0.2	0.4	-0.1	0.2	0.4	-0.4	-0.6	-0.5	0.4
Intermittent access intake day 1-15 change	0.8	0.8	1.2	-0.5	-1.1	-1.1	1.1	-0.8	-0.8	0.9
Intermittent access intake escalation	0.5	0.5	0.6	-0.3	-0.8	-0.8	0.8	-0.7	-0.7	0.7
Intermittent access intake escalation 2	3.3	3.3	4.2	-1.4	-2.0	-2.0	2.1	-1.7	-1.7	1.8
Intermitt. access day 1 inactive lever presses	1.7	1.8	2.7	-0.7	-1.4	-1.6	1.6	-1.3	-1.2	1.3
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.8	0.4	-0.1	-0.3	0.3	-0.9	-0.7	0.7
Intermitt. access escalation Index	0.3	0.3	0.5	0.7	0.6	0.5	-0.5	-0.6	-0.3	0.3
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.0	-0.3	-0.2	0.2	-0.5	-0.4	0.4
Intermittent access day 15 total infusions	0.2	0.3	0.6	0.0	-0.4	-0.4	0.4	-0.8	-0.7	0.7
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.6	-0.4	-0.8	-0.8	0.7	-1.3	-1.2	1.2
Intermittent access total infusions	0.2	0.2	0.5	-0.0	-0.3	-0.3	0.3	-0.7	-0.6	0.6
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.2	0.1	0.1	-0.1	-0.5	-0.4	0.4
Intermittent access day 15 total locomotion	0.5	0.6	0.9	-0.6	-0.7	-0.5	0.4	-0.9	-0.9	0.9
Intermittent access total locomotion	0.3	0.3	0.7	-0.3	-0.4	-0.3	0.3	-0.8	-0.8	0.8
Intermittent access standard deviation	0.7	0.8	1.4	-1.2	-1.1	-1.1	1.2	-0.1	-0.3	0.3
Cocaine induced anxiety	8.4	9.7	14.0	-2.2	-3.4	-3.7	3.7	-2.8	-2.8	2.8
Post-drug Anxiety	1.9	2.1	4.2	-1.0	-1.7	-2.0	2.1	-0.8	-1.0	1.0
Baseline Anxiety	8.0	8.5	9.9	1.6	3.1	3.1	-3.1	3.1	3.0	-3.0
Lifetime Intake	0.0	0.1	0.1	-0.0	-0.1	0.0	-0.1	-0.4	-0.3	0.3
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.2	-0.4	-0.4	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.2	-0.4	-0.4	0.4
Progressive ratio test 1 active lever presses	0.4	0.4	0.9	0.0	-0.5	-0.4	0.4	-1.0	-0.9	0.9
Progressive ratio test 1 breakpoint	0.6	0.6	1.2	-0.0	-0.6	-0.6	0.5	-1.1	-1.0	1.0
Progressive ratio test 1 inactive lever presses	1.1	1.1	2.2	0.1	-0.8	-1.0	0.9	-1.5	-1.3	1.3
Progressive ratio test 2 active lever presses	0.3	0.3	0.6	-0.4	-0.4	-0.3	0.2	-0.8	-0.7	0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	-0.1	-0.2	-0.0	0.0	-0.7	-0.6	0.6
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.8	-0.6	-0.7	-0.7	0.7	-0.9	-0.8	0.8
Total sessions with >9 infusions	0.4	0.5	1.2	0.2	0.7	1.1	-1.1	0.4	0.4	-0.4
Short access day 1 total inactive lever presses	0.7	0.8	1.8	0.7	1.2	1.3	-1.4	0.1	0.3	-0.3
Short access day 10 total inactive lever presses	2.9	3.2	3.9	-0.9	-1.9	-1.8	1.8	-2.0	-1.9	1.9
Short access day 1 total infusions	1.0	1.0	1.3	0.3	1.0	1.2	-1.1	1.1	1.1	-1.1
Short access day 10 total infusions	0.6	0.7	0.8	-0.5	-0.9	-0.7	0.7	-0.9	-0.9	0.9
Short access total infusions	0.0	0.0	0.0	-0.0	0.0	0.2	-0.2	0.0	-0.0	0.0
Short access day 1 locomotion	0.1	0.1	0.4	-0.7	-0.0	0.4	-0.4	0.1	-0.0	-0.0
Short access day 10 total locomotion	0.3	0.4	1.2	-1.1	-0.7	-0.5	0.5	-0.3	-0.5	0.4
Short access total locomotion	0.1	0.1	0.6	-0.8	-0.1	0.4	-0.4	0.1	-0.1	0.0
Compulsive drug intake	0.2	0.2	0.3	0.4	-0.2	-0.6	0.5	-0.4	-0.3	0.3
One hour access (0.3 mA shock)	0.4	0.5	0.9	0.2	-0.5	-0.6	0.5	-1.0	-0.9	0.9
One hour access (shock baseline)	0.2	0.2	0.4	0.1	0.3	0.6	-0.6	-0.5	-0.4	0.3
Number of responses in last shaping day	0.5	0.5	1.5	-0.2	-0.2	-0.1	0.1	-1.2	-1.0	1.0
Context. condit. distance diff. score	0.7	0.9	3.5	1.9	0.9	0.7	-0.8	0.3	0.6	-0.5
Locomotion velocity, session 1	0.4	0.4	1.0	-1.0	-0.1	0.2	-0.2	1.0	0.7	-0.8
Locomotion distance, session 1	3.4	4.4	5.1	1.7	2.1	2.0	-2.0	2.2	2.3	-2.3
Locomotion velocity, session 2	2.3	2.7	4.2	0.1	1.4	1.8	-1.7	2.1	1.8	-1.9
Locomotion distance, session 2	1.2	1.7	1.8	1.3	1.4	1.3	-1.3	1.2	1.3	-1.2
Locomotion velocity, session 3	0.4	0.5	1.1	-0.4	0.4	0.4	-0.4	1.0	0.9	-0.9
Locomotion distance, session 3	1.8	2.0	3.5	0.5	1.3	1.1	-1.1	1.9	1.7	-1.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.5	0.0	0.3	-0.2	0.4	0.3	-0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.1	0.2	0.4	-0.4	0.4	0.4	-0.4
Locomotion velocity, session 7	0.6	0.7	1.0	0.6	0.9	0.6	-0.6	1.0	1.0	-1.0
Locomotion distance, session 7	4.6	5.9	7.2	2.3	2.4	2.2	-2.1	2.6	2.7	-2.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	0.1	-0.1	-0.4	0.4	-0.3	-0.3	0.3
Stereotopy head waving duration, day 7	0.4	0.4	0.8	-0.5	-0.4	-0.4	0.4	-0.9	-0.9	0.8
Locomotion velocity, session 8	1.8	2.2	2.8	1.7	1.6	1.5	-1.5	1.3	1.4	-1.4
Locomotion distance, session 8	2.4	3.6	9.0	3.0	2.1	1.7	-1.8	1.2	1.5	-1.4
Degree of sensitization distance	0.2	0.2	1.0	1.0	0.2	0.2	-0.3	-0.1	0.0	-0.0
Degree of sensitization stereotypy	0.2	0.2	0.3	0.2	-0.1	-0.5	0.5	-0.5	-0.4	0.4
Condit. Reinf. active minus inactive responses	1.1	1.3	2.0	-0.1	-1.0	-1.1	1.1	-1.4	-1.3	1.3
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.0	0.0	-0.6	-1.0	1.0	-0.9	-0.8	0.8
Condit. Reinf. active responses	1.8	2.2	4.0	-0.2	-1.2	-1.3	1.2	-2.0	-1.8	1.8
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.1	-0.6	-0.6	0.5	-1.0	-0.9	0.9
Incentive salience index mean	0.7	0.9	1.8	-0.1	-0.7	-0.8	0.7	-1.4	-1.2	1.2
Condit. Reinf. lever presses	0.2	0.3	0.5	0.6	0.7	0.7	-0.7	0.1	0.2	-0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.2	-0.5	-0.6	0.6	0.1	0.0	-0.0
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.3	0.4	0.4	-0.4	0.0	0.1	-0.1
Total zone transitions, hab. session 1	0.5	0.8	1.1	1.0	0.7	0.5	-0.5	1.0	1.1	-1.0
Total locomotion distance, hab. session 1	0.2	0.3	1.3	1.1	0.6	-0.1	0.1	0.3	0.4	-0.4
Locomotion velocity, hab. session 1	0.2	0.3	1.2	1.1	0.6	-0.1	0.0	0.2	0.4	-0.3
Time in familiar zone, hab. session 2	0.4	0.4	0.7	0.8	0.6	0.2	-0.1	0.8	0.8	-0.8
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.1	0.0	0.6	-0.6	0.1	0.0	-0.1
Total zone transitions, hab. session 2	2.0	2.6	4.4	2.1	1.6	1.5	-1.5	1.3	1.5	-1.5
Total locomotion distance, hab. session 2	0.9	1.2	3.7	1.9	1.2	1.0	-1.1	0.3	0.6	-0.6
Locomotion velocity, hab. session 2	0.6	0.8	3.0	1.7	1.0	0.8	-0.8	0.0	0.3	-0.3
Novel to familiar place preference ratio	4.1	4.3	5.9	-1.4	-2.1	-2.4	2.4	-1.9	-2.0	2.0
Novelty place preference	4.1	4.2	5.7	-1.5	-2.2	-2.4	2.4	-1.9	-2.0	2.0
Time in novel zone, NPP test	3.0	3.2	4.3	-1.2	-1.9	-2.1	2.1	-1.6	-1.7	1.7
Total zone transitions, NPP test	2.9	4.2	6.2	2.5	2.2	2.1	-2.1	1.6	1.9	-1.8
Total locomotion distance, NPP test	2.0	2.8	6.4	2.5	2.0	1.6	-1.6	0.9	1.3	-1.2
Locomotion velocity, NPP test	1.1	1.5	4.3	2.1	1.5	1.1	-1.1	0.6	0.9	-0.8
Pavlov. Cond. lever latency	3.0	3.8	6.3	2.5	1.9	1.3	-1.3	2.0	2.2	-2.1
Pavlov. Cond. magazine entry latency	4.5	5.8	6.3	-2.2	-2.5	-2.5	2.5	-2.3	-2.4	2.4
Pavlov. Cond. change in total contacts	2.0	2.1	3.2	-1.6	-1.4	-1.7	1.8	-1.0	-1.2	1.2
Pavlov. Cond. index score	4.5	5.8	7.3	-2.2	-2.3	-2.1	2.0	-2.7	-2.7	2.7
Pavlov. Cond. latency score	4.3	5.5	6.9	-2.4	-2.3	-1.9	1.9	-2.6	-2.6	2.6
Pavlov. Cond. lever contacts	1.6	1.9	2.6	-1.6	-1.2	-0.9	0.8	-1.6	-1.6	1.6
Pavlov. Cond. magazine entry number	5.3	6.7	7.8	2.6	2.8	2.7	-2.7	2.3	2.5	-2.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.2	1.1	0.5	0.4	-0.4	0.1	0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	4.8	6.0	7.2	-2.2	-2.4	-2.2	2.2	-2.7	-2.7	2.7
Pavlov. Cond. response bias	4.5	5.5	6.1	-2.4	-2.5	-2.3	2.3	-2.3	-2.4	2.4
Bone: apparent density	0.0	0.0	0.2	0.4	0.2	0.0	-0.0	-0.2	-0.1	0.2
Bone surface	0.2	0.3	0.7	-0.5	-0.3	-0.2	0.2	-0.8	-0.8	0.8
Bone volume	0.1	0.2	0.4	-0.1	-0.2	-0.3	0.3	-0.6	-0.5	0.6
Bone: connectivity density	0.4	0.7	1.4	0.8	0.9	1.1	-1.2	0.4	0.5	-0.5
Bone: cortical apparent density	1.2	1.5	3.1	0.3	0.9	0.8	-0.8	1.8	1.6	-1.6
Bone: cortical area	5.4	8.3	12.2	-1.7	-2.3	-2.8	2.7	-3.5	-3.3	3.4
Bone: cortical porosity	4.7	5.1	6.6	-2.6	-2.4	-2.5	2.5	-1.7	-2.0	2.0
Bone: cortical porosity	4.1	4.4	5.8	-2.2	-2.2	-2.4	2.4	-1.7	-1.9	1.9
Bone: cortical thickness	6.0	10.0	12.5	-2.4	-2.8	-3.1	3.1	-3.5	-3.5	3.5
Bone: cortical thickness	2.0	2.3	3.1	-0.9	-1.2	-1.8	1.7	-1.6	-1.6	1.6
Bone: cortical tissue density	1.3	1.7	3.6	0.3	1.0	0.9	-0.8	1.9	1.7	-1.7
Bone: elastic displacement	1.9	2.1	2.6	-1.0	-1.3	-1.6	1.6	-1.5	-1.5	1.5
Bone: elastic work	10.6	13.7	15.9	-2.9	-3.6	-4.0	4.0	-3.7	-3.8	3.8
Bone: endosteal estimation	0.3	0.6	1.7	1.3	0.8	0.7	-0.7	0.5	0.7	-0.6
Bone: endosteal perimeter	0.5	1.1	1.9	-0.6	-0.7	-0.8	0.8	-1.4	-1.3	1.3
Bone: final force	4.3	7.0	10.1	-1.3	-2.3	-2.7	2.6	-3.2	-3.0	3.0
Bone: final moment	5.5	9.0	12.1	-1.6	-2.6	-3.1	3.1	-3.5	-3.3	3.4
Bone: marrow area	0.3	0.6	1.7	1.3	0.8	0.7	-0.7	0.5	0.7	-0.7
Bone: maximum diameter	1.2	2.2	4.2	-1.0	-0.8	-1.0	1.0	-2.0	-1.9	1.9
Bone: maximum force	3.8	6.6	10.0	-1.1	-2.2	-2.5	2.4	-3.2	-3.0	3.0
Bone: maximum moment	4.8	8.4	11.9	-1.4	-2.6	-2.9	2.9	-3.4	-3.3	3.3
Bone: minimum diameter	3.0	5.6	7.9	-1.4	-1.8	-2.4	2.4	-2.8	-2.7	2.7
Bone: periosteal estimation	1.1	2.2	4.0	-0.4	-1.0	-1.4	1.4	-2.0	-1.8	1.8
Bone: periosteal perimeter	4.4	7.3	9.5	-2.4	-2.3	-2.4	2.4	-3.1	-3.1	3.0
Bone: post-yield work	0.4	0.5	0.9	1.0	0.7	0.8	-0.9	0.5	0.6	-0.6
Bone: stiffness	0.3	0.5	1.0	-0.1	-0.6	-0.5	0.5	-1.0	-0.9	0.9
Bone: tissue strength	0.3	0.3	0.7	0.4	-0.2	-0.2	0.2	-0.8	-0.7	0.7
Bone: trabecular number	0.0	0.0	0.1	0.0	0.1	0.3	-0.3	-0.0	-0.0	0.0
Bone: trabecular spacing	1.3	1.6	5.5	2.3	1.4	0.9	-0.9	0.7	1.0	-0.9
Bone: trabecular thickness	2.4	2.9	4.1	-2.0	-1.9	-1.8	1.8	-1.3	-1.5	1.5
Bone: trabecular tissue density	0.5	0.7	1.0	0.3	0.7	0.9	-0.8	1.0	1.0	-1.0
Breakpoint value in progressive ratio session	1.6	1.7	3.9	-0.8	-1.4	-1.9	2.0	-0.7	-0.8	0.8
Distance traveled before self-admin	2.7	2.9	4.7	-1.2	-1.9	-2.2	2.2	-1.4	-1.4	1.5
Distance traveled after self-admin	0.1	0.1	0.5	0.7	-0.1	-0.5	0.5	-0.2	-0.1	0.1
Delta time in closed arm before/after self-admin	0.6	0.6	1.9	-0.1	0.7	1.3	-1.4	-0.2	-0.1	0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.6	0.8	0.2	-0.4	0.4	0.3	0.4	-0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.1	0.1	-0.0	0.1	0.2	0.2	-0.2
Extinction: sum of active levers before priming	0.3	0.3	1.0	-0.0	0.3	0.1	-0.1	1.0	0.8	-0.8
Active lever presses in extinction session 6	0.7	0.7	1.7	-0.7	-0.8	-1.3	1.3	-0.1	-0.2	0.2
Delta distance traveled before/after self-admin	1.7	1.8	2.5	1.6	1.5	1.3	-1.3	1.1	1.3	-1.2
Delta ambulatory time before/after self-admin	2.7	2.9	3.5	1.6	1.9	1.8	-1.8	1.6	1.6	-1.6
Time in closed arm before self-admin	0.4	0.4	1.0	-0.7	-0.8	-0.9	1.0	0.2	0.0	0.0
Time in closed arm after self-admin	0.4	0.5	2.3	-1.5	-0.8	-0.2	0.3	0.1	-0.2	0.2
Time in open arm before self-admin	0.7	0.8	2.3	0.2	1.0	1.4	-1.5	-0.1	0.0	-0.1
Time in open arm after self-admin	0.5	0.6	0.9	1.0	1.0	0.7	-0.8	0.5	0.6	-0.6
Sum of active levers in priming session hrs 5-6	2.2	2.2	6.0	-0.4	-1.5	-2.4	2.5	-0.5	-0.6	0.7
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	0.1	0.2	-0.2	-0.2	-0.1	0.1
Time to tail flick, vehicle, after self-admin	1.8	1.9	3.2	0.4	1.4	1.8	-1.8	1.4	1.3	-1.3
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.6	-0.6	-0.4	0.4	-0.3	-0.4	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.2	0.3	0.6	-0.6	0.2	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.8	1.2	0.7	1.1	1.1	-1.1	0.7	0.8	-0.8
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.2	0.1	0.1	-0.1	0.5	0.4	-0.4
Ambulatory time before self-admin	3.7	3.8	5.7	-1.2	-2.1	-2.4	2.4	-1.8	-1.8	1.8
Ambulatory time after self-admin	0.1	0.1	0.3	0.4	-0.2	-0.5	0.5	-0.3	-0.2	0.2
Total heroin consumption	1.0	1.2	2.7	-0.9	-1.1	-1.6	1.6	-0.5	-0.6	0.6
Area under the delay curve	1.2	1.3	2.1	0.5	1.1	0.9	-0.8	1.4	1.4	-1.4
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	0.0	0.1	-0.1
Delay disc. indifference point, 16s delay	3.5	3.6	4.4	1.8	2.1	1.7	-1.6	1.9	2.0	-2.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.1	0.3	0.1	-0.1	0.4	0.4	-0.4
Delay disc. indifference point, 24s delay	1.9	1.8	3.7	0.0	1.1	1.0	-0.9	1.9	1.7	-1.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.1	0.3	0.3	-0.3	0.6	0.5	-0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	-0.4	0.2	0.1	-0.1	0.7	0.6	-0.6
Delay discount exponential model param	1.3	1.3	2.6	-0.3	-1.0	-0.9	0.8	-1.6	-1.5	1.5
Delay discount hyperbolic model param	1.2	1.3	2.4	-0.3	-1.0	-0.8	0.8	-1.6	-1.4	1.5
Fecal boli incidents, locomotor time 1	0.7	0.7	0.8	0.6	0.9	0.9	-0.9	0.9	0.9	-0.9
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	-0.9	-0.5	-0.3	0.4	0.9	0.6	-0.6
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.1	1.1	0.7	0.9	-1.0	0.2	0.2	-0.2
Bouts of movement, locomotor time 1	0.9	1.0	2.0	0.4	0.8	0.8	-0.8	1.4	1.3	-1.3
Total resting periods, locomotor time 1	0.8	0.9	1.9	0.0	0.6	0.7	-0.7	1.4	1.2	-1.2
Rest time, locomotor task time 1	0.1	0.1	0.6	-0.8	-0.4	-0.3	0.4	-0.0	-0.1	0.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.4	-0.0	-0.0	-0.0	-0.5	-0.4	0.4
Vertical activity count, locomotor time 1	0.2	0.2	0.9	0.9	0.4	0.3	-0.3	-0.5	-0.3	0.3
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.9	-0.1	0.3	0.9	-1.0	-0.2	-0.2	0.2
Bouts of movement, locomotor time 2	1.4	1.5	2.0	0.8	1.2	1.2	-1.2	1.4	1.3	-1.4
Total resting periods, locomotor time 2	1.5	1.6	1.9	1.0	1.3	1.4	-1.4	1.2	1.2	-1.2
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.2	0.2	0.4	-0.4	0.1	0.1	-0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.0	0.1	0.2	-0.2	-0.2	-0.1	0.1
Vertical activity count, locomotor time 2	0.4	0.5	0.9	1.0	0.9	0.8	-0.9	0.1	0.3	-0.3
Weight adjusted by age	2.7	3.0	3.9	-0.8	-1.7	-1.9	1.9	-2.0	-1.8	1.8
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.7	-0.3	-0.7	-0.7	0.7	-1.3	-1.2	1.2
Locomotion in novel chamber	0.6	0.7	1.1	0.9	1.0	0.9	-0.9	0.6	0.7	-0.7
Locomotion in novel chamber post-restriction	1.4	1.7	2.4	-0.7	-1.4	-1.1	1.1	-1.5	-1.5	1.5
Progressive ratio	0.2	0.2	0.4	0.2	0.5	0.3	-0.3	0.7	0.6	-0.6
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.5	-0.3	-0.5	0.6	0.2	0.0	-0.0
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.3	-0.2	0.2
Run reversals in cocaine runway, females	1.8	1.8	2.4	1.5	1.4	0.9	-0.9	1.5	1.5	-1.5
Run reversals in cocaine runway, males	2.9	2.8	3.3	-1.6	-1.8	-1.7	1.7	-1.6	-1.7	1.7
Latency to leave start box in cocaine runway	0.5	0.5	0.6	0.6	0.6	0.7	-0.7	0.8	0.7	-0.7
Latency to leave start box in cocaine runway, F	1.3	1.4	2.1	1.2	1.3	1.4	-1.5	0.9	1.0	-1.0
Latency to leave start box in cocaine runway, M	0.2	0.1	0.4	-0.4	-0.6	-0.4	0.4	-0.2	-0.3	0.3
Cd content in liver	1.8	2.0	3.2	1.2	1.1	0.9	-0.9	1.8	1.8	-1.7
Co content in liver	0.1	0.2	0.3	0.4	0.5	-0.0	0.0	0.4	0.5	-0.4
Cu content in liver	1.6	2.0	3.0	-1.7	-1.3	-1.5	1.5	-1.1	-1.3	1.3
Fe content in liver	0.9	1.1	1.3	0.7	1.2	0.9	-0.9	1.1	1.1	-1.2
K content in liver	0.6	0.6	1.6	0.2	-0.0	-0.1	0.1	-1.3	-1.0	1.1
Mg content in liver	1.1	1.1	2.0	1.4	1.2	1.4	-1.4	0.2	0.4	-0.4
Mn content in liver	0.3	0.3	0.6	-0.6	-0.4	-0.2	0.2	-0.8	-0.7	0.7
Na content in liver	0.1	0.1	0.1	-0.3	0.1	0.1	-0.1	-0.3	-0.3	0.3
Rb content in liver	0.1	0.2	0.7	0.8	0.3	0.0	-0.1	-0.4	-0.3	0.3
Se content in liver	0.1	0.1	0.2	0.1	-0.2	-0.2	0.2	-0.4	-0.4	0.4
Sr content in liver	1.1	1.0	2.5	-1.6	-1.1	-1.1	1.2	-0.4	-0.6	0.6
Zn content in liver	0.2	0.3	0.7	-0.8	-0.2	0.5	-0.5	-0.4	-0.5	0.4