Hub : Genes

P4hb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000036689	0.08	0.06	3.7e-03	0.03	0.04	0.03	0.02	1.5e-02	5.7e-03	1.3e-02	2.9e-02
2	Liver	gene expression	ENSRNOG00000036689	0.04	0.03	2.4e-05	0.04	0.03	0.03	0.03	2.9e-05	1.1e-04	2.7e-04	2.1e-04
3	Liver	isoform ratio	ENSRNOT00000054958	0.02	0.02	4.9e-03	0.02	0.02	0.02	0.02	9.6e-04	1.7e-03	5.6e-03	1.6e-03
4	Liver	isoform ratio	ENSRNOT00000100112	0.02	0.02	3.8e-03	0.02	0.02	0.02	0.02	1.5e-03	1.8e-03	3.6e-03	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	0.6	2.1	2.8	-1.7	0.9	1.5	-1.5
BMI without tail	5.4	11.3	15.8	-4.0	1.4	3.6	-3.8
Body weight	3.1	13.3	22.9	-1.5	-2.4	4.8	-4.7
Epididymis fat weight	1.0	2.4	3.8	-1.4	-0.1	1.9	-1.9
Glucose	3.9	6.0	10.5	3.2	0.2	-2.6	2.6
Heart weight	0.2	0.3	0.5	-0.3	0.2	0.7	-0.7
Left kidney weight	0.4	1.2	3.5	1.1	-1.9	0.4	-0.3
Right kidney weight	0.2	0.7	2.3	0.6	-1.5	-0.0	0.1
Tail length	4.5	13.7	22.8	-2.5	-1.9	4.7	-4.8
Length with tail	2.7	10.0	14.3	0.3	-3.8	3.6	-3.5
Length without tail	2.2	4.9	9.7	3.1	-3.1	-0.4	0.5
Liver weight, left	0.5	0.8	2.1	1.5	-0.7	-0.4	0.5
Liver weight, right	2.5	4.1	7.4	0.2	-2.7	2.2	-2.1
Parametrial fat weight	1.4	2.7	4.4	-0.4	-1.4	2.1	-2.1
Retroperitoneal fat weight	3.4	11.4	20.7	-1.7	-1.5	4.5	-4.5
Intraocular pressure	0.5	0.7	1.0	-0.9	0.4	1.0	-1.0
Extensor digitorum longus weight	0.6	2.3	5.7	-2.4	1.7	0.6	-0.6
Soleus weight	1.1	3.2	5.3	-0.7	-1.4	2.3	-2.3
Tibialis anterior weight	0.1	0.3	0.9	-1.0	0.3	0.3	-0.3
Tibia length	7.2	20.2	27.5	1.2	-4.9	5.2	-5.2
Number of licking bursts	0.2	0.3	0.4	-0.6	-0.5	0.5	-0.5
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.5	-0.1	0.9	-0.8
Times rat made contact with spout	1.2	1.4	2.6	1.2	-1.6	0.9	-0.9
Mean time between licks in bursts	1.1	1.5	2.4	0.0	1.1	-1.6	1.6
Mean num. licks in bursts	0.2	0.2	0.9	0.9	-0.2	0.2	-0.2
Std. dev. time between licks in bursts	2.6	3.1	7.7	-2.8	1.5	1.1	-1.1
Water consumed over 24 hours	0.6	0.7	1.5	1.2	-1.1	-0.3	0.3
Indifference point 0 sec	0.0	0.1	0.1	-0.2	0.2	0.3	-0.3
Indifference point AUC	0.0	0.0	0.1	-0.2	0.3	-0.1	0.1
Indifference point function ln k	0.5	0.8	1.1	-0.2	1.1	-1.0	1.0
Indifference point function log k	0.5	0.8	1.1	-0.2	1.1	-1.0	1.0
Delay discounting total patch changes 0 sec	0.1	0.2	0.4	-0.5	0.6	0.4	-0.3
Delay discounting total patch changes 12 sec	0.0	0.0	0.1	0.3	0.0	-0.1	0.1
Delay discounting total patch changes 18 sec	0.8	1.0	2.7	-1.1	1.6	-0.0	0.0
Delay discounting total patch changes 24 sec	0.6	0.7	1.2	-0.7	0.2	1.1	-1.0
Delay discounting total patch changes 6 sec	0.3	0.5	0.9	0.4	-0.9	0.6	-0.6
Delay discounting time to switch 0 sec	0.3	0.4	0.7	0.5	0.3	-0.8	0.8
Delay discounting water rate 0 sec	1.9	3.0	4.7	-1.6	0.1	2.2	-2.2
Delay discounting water rate 12 sec	0.9	1.3	2.5	-1.6	1.4	0.7	-0.7
Delay discounting water rate 18 sec	1.2	1.6	2.9	-1.7	0.5	1.3	-1.2
Delay discounting water rate 24 sec	3.5	4.8	7.5	-2.7	1.7	2.1	-2.1
Delay discounting water rate 6 sec	0.3	0.4	0.9	-1.0	0.3	0.5	-0.5
Locomotor activity	0.4	0.6	1.1	0.3	0.6	-1.0	1.0
Locomotor testing distance	0.4	0.6	1.1	-0.4	1.1	-0.7	0.8
Locomotor testing rearing	0.3	0.4	1.1	-0.7	1.1	-0.2	0.3
Light reinforcement 1	1.4	2.5	3.6	-1.9	0.2	1.8	-1.7
Light reinforcement 2	2.0	2.7	4.3	-1.1	-1.0	2.1	-2.0
Reaction time number correct	3.9	5.5	13.6	-3.7	2.7	0.8	-0.8
Reaction time mean minus median	0.5	0.7	1.4	1.2	-1.0	-0.3	0.3
Reaction time mean minus median AUC	0.4	0.5	1.8	0.6	-1.3	0.2	-0.2
Reaction time num false alarms	0.3	0.4	0.8	-0.0	0.9	-0.6	0.6
Reaction time num false alarms AUC	0.4	0.6	0.9	-0.1	1.0	-0.8	0.9
Reaction time trials correct on left	3.9	5.5	13.6	-3.7	2.7	0.8	-0.8
Reaction time trials on left	4.0	5.7	14.1	-3.8	2.7	0.9	-0.9
Reaction time mean	0.3	0.3	0.6	-0.5	0.1	0.8	-0.7
Reaction time mean AUC	0.4	0.6	0.9	-0.9	0.3	0.8	-0.8
Median of all reaction times	0.4	0.6	0.8	-0.9	0.6	0.8	-0.8
Reaction time omissions	0.4	0.6	0.8	-0.9	0.1	0.9	-0.8
Reaction time false alarm rate	1.0	1.5	2.9	1.7	-0.4	-1.2	1.2
Reaction time premature initiation rate	1.1	1.4	2.1	0.3	1.2	-1.4	1.4
Reaction time premature initiations	1.9	2.6	6.2	-1.7	2.5	-0.8	0.8
Std. dev. reaction times	0.1	0.2	0.2	0.0	0.4	-0.5	0.5
Reaction time trials completed	4.0	5.7	14.1	-3.8	2.7	0.9	-0.9
Reaction time trials AUC	3.9	5.6	14.0	-3.7	2.6	0.9	-0.9
Social response proportion	0.3	0.3	0.6	-0.5	0.8	-0.5	0.5
Social responses	0.0	0.1	0.2	-0.4	0.1	-0.1	0.1
Social time	0.1	0.2	0.2	-0.5	0.5	-0.3	0.3
Conditioned locomotion	3.7	4.4	7.2	-1.7	-0.6	2.7	-2.7
Cocaine response after cond. corrected	0.2	0.2	0.4	0.5	0.7	-0.3	0.3
Cocaine response after cond. not corrected	0.6	0.6	0.8	0.6	0.8	-0.9	0.9
Cocaine response before conditioning	0.4	0.4	0.8	-0.2	0.2	-0.9	0.9
Saline control response	2.3	3.0	5.0	-0.6	-1.4	2.2	-2.2
Condit. Reinf. active minus inactive responses	0.7	0.8	1.4	-0.4	-0.7	1.1	-1.2
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.6	0.3	-1.6	1.5	-1.6
Condit. Reinf. active responses	0.3	0.4	0.6	-0.8	0.4	0.6	-0.6
Condit. Reinf. inactive responses	0.8	1.0	2.5	-0.7	1.6	-0.7	0.7
Condit. Reinf. lever presses	0.7	1.0	1.8	-1.3	1.1	0.7	-0.7
Condit. Reinf. lever reinforcers received	0.6	0.9	1.5	-1.2	1.1	0.7	-0.7
Pavlov. Cond. lever latency	1.3	1.8	3.3	1.8	-1.1	-1.2	1.2
Pavlov. Cond. magazine entry latency	2.3	2.7	6.1	-1.4	2.5	-1.2	1.2
Pavlov. Cond. change in total contacts	1.3	1.8	4.5	-1.6	2.1	-0.1	0.1
Pavlov. Cond. index score	1.4	1.8	4.6	-1.6	2.1	0.0	-0.0
Pavlov. Cond. latency score	1.4	1.8	4.2	-1.7	2.0	0.1	-0.1
Pavlov. Cond. lever contacts	1.6	2.2	4.1	-2.0	1.1	1.4	-1.4
Pavlov. Cond. magazine entry number	2.1	2.5	6.3	1.5	-2.5	0.8	-0.9
Pavlov. Cond. intertrial magazine entries	1.2	1.6	2.6	-0.5	-1.0	1.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	5.3	-1.6	2.3	-0.1	0.2
Pavlov. Cond. response bias	1.1	1.5	3.0	-1.7	1.6	0.5	-0.5
Conditioned reinforcement - actives	0.3	0.3	0.5	-0.7	-0.4	0.5	-0.5
Conditioned reinforcement - inactives	1.4	1.6	2.7	-0.1	-1.1	1.6	-1.6
Conditioned locomotion	0.5	0.6	1.4	-0.2	-1.2	0.8	-0.7
Intermittent access intake day 1-15 change	0.4	0.4	0.7	0.1	-0.5	0.8	-0.9
Intermittent access intake escalation	0.4	0.4	0.8	-0.2	-0.3	0.9	-0.9
Intermittent access intake escalation 2	1.5	1.5	2.0	0.7	-1.3	1.4	-1.4
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.4	0.1	-0.4	1.2	-1.2
Intermitt. access day 15 inactive lever presses	1.6	1.8	3.1	-1.0	-0.4	1.8	-1.7
Intermitt. access escalation Index	1.5	1.4	1.9	-1.3	-0.3	1.4	-1.3
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.3	-0.2	0.5	-0.5
Intermittent access day 15 total infusions	0.6	0.7	1.2	-0.6	-0.3	1.1	-1.1
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.9	-0.3	-1.0	1.4	-1.4
Intermittent access total infusions	0.4	0.5	0.8	-0.5	-0.4	0.9	-0.9
Intermittent access day 1 locomotion	0.6	0.6	0.9	-0.7	-0.4	0.9	-0.9
Intermittent access day 15 total locomotion	0.6	0.6	1.5	0.3	-1.2	0.7	-0.7
Intermittent access total locomotion	0.6	0.7	1.0	-0.2	-0.9	1.0	-1.0
Intermittent access standard deviation	0.7	0.8	2.2	1.5	-0.2	-0.7	0.7
Cocaine induced anxiety	2.6	3.0	4.6	1.1	-1.4	2.1	-2.1
Post-drug Anxiety	0.3	0.3	0.6	0.8	-0.0	0.5	-0.5
Baseline Anxiety	4.6	4.9	8.4	-0.1	1.7	-2.9	2.9
Lifetime Intake	0.2	0.2	0.3	-0.2	-0.4	0.5	-0.5
Incentive Sensitization - Responses	0.1	0.1	0.3	0.0	-0.5	0.3	-0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.2	-0.6	0.2	-0.3
Progressive ratio test 1 active lever presses	0.9	1.0	1.6	-0.6	-0.6	1.3	-1.3
Progressive ratio test 1 breakpoint	1.1	1.1	2.0	-0.7	-0.6	1.4	-1.4
Progressive ratio test 1 inactive lever presses	2.4	2.6	4.4	-1.1	-0.4	2.1	-2.1
Progressive ratio test 2 active lever presses	0.4	0.4	0.9	0.0	-0.9	0.7	-0.7
Progressive ratio test 2 breakpoint	0.5	0.5	0.7	-0.4	-0.8	0.8	-0.8
Progressive ratio test 2 inactive lever presses	0.5	0.5	0.7	0.2	-0.8	0.9	-0.8
Total sessions with >9 infusions	0.2	0.2	0.4	0.1	-0.7	-0.3	0.3
Short access day 1 total inactive lever presses	0.3	0.4	0.9	-0.9	-0.4	0.5	-0.5
Short access day 10 total inactive lever presses	1.9	2.1	3.6	-0.2	-1.1	1.9	-1.9
Short access day 1 total infusions	0.8	0.9	1.6	0.5	0.2	-1.2	1.3
Short access day 10 total infusions	0.4	0.4	0.6	0.1	-0.7	0.7	-0.7
Short access total infusions	0.0	0.0	0.1	0.1	-0.2	-0.0	0.0
Short access day 1 locomotion	0.8	0.8	1.1	1.0	-1.0	-0.8	0.8
Short access day 10 total locomotion	0.7	0.8	1.6	1.3	-1.1	-0.4	0.4
Short access total locomotion	1.0	1.0	1.4	1.2	-1.2	-0.8	0.8
Compulsive drug intake	0.7	0.7	0.9	-0.8	0.6	0.9	-0.9
One hour access (0.3 mA shock)	1.0	1.2	2.0	-0.8	-0.4	1.4	-1.4
One hour access (shock baseline)	0.3	0.4	0.9	-0.4	-0.9	0.5	-0.5
Number of responses in last shaping day	1.7	1.8	2.7	-0.5	-1.3	1.6	-1.5
Context. condit. distance diff. score	1.8	2.2	5.3	-2.3	1.3	1.0	-1.0
Locomotion velocity, session 1	2.7	2.9	4.0	1.9	0.0	-2.0	2.0
Locomotion distance, session 1	2.1	2.8	3.8	-0.8	1.9	-1.8	1.8
Locomotion velocity, session 2	3.6	4.2	7.4	1.2	0.6	-2.7	2.7
Locomotion distance, session 2	0.5	0.8	1.3	-1.0	1.2	-0.6	0.6
Locomotion velocity, session 3	1.5	1.8	2.8	1.1	0.5	-1.7	1.7
Locomotion distance, session 3	2.4	2.6	4.3	0.5	1.3	-2.1	2.1
Stereotopy head waving bouts, day 3	0.6	0.7	1.1	1.0	-0.2	-1.0	1.0
Stereotopy head waving duration, day 3	0.3	0.3	0.5	0.5	-0.1	-0.7	0.7
Locomotion velocity, session 7	0.5	0.6	0.8	-0.2	0.9	-0.9	0.9
Locomotion distance, session 7	2.8	3.6	6.6	-1.3	2.6	-1.7	1.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.3	0.1	0.5	-0.5
Stereotopy head waving duration, day 7	0.4	0.5	0.8	0.1	-0.9	0.7	-0.7
Locomotion velocity, session 8	1.0	1.1	2.2	-1.3	1.5	-0.6	0.6
Locomotion distance, session 8	2.7	4.0	10.3	-3.2	2.2	0.6	-0.6
Degree of sensitization distance	0.9	0.9	1.7	-1.3	0.4	0.9	-0.9
Degree of sensitization stereotypy	0.4	0.4	0.7	-0.6	0.2	0.8	-0.8
Condit. Reinf. active minus inactive responses	1.7	1.9	3.3	-0.8	-0.5	1.8	-1.8
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.4	-0.6	-0.1	1.2	-1.2
Condit. Reinf. active responses	3.1	3.7	6.5	-1.2	-0.9	2.5	-2.5
Condit. Reinf. inactive responses	0.7	0.9	1.6	-0.6	-0.4	1.2	-1.2
Incentive salience index mean	1.5	1.7	2.9	-0.9	-0.6	1.7	-1.7
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.8	0.1	0.2	-0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	0.3	-0.3	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.4	-0.0	0.2	-0.2
Total zone transitions, hab. session 1	0.6	0.8	2.1	-0.7	1.5	-0.6	0.6
Total locomotion distance, hab. session 1	0.8	1.1	1.9	-1.4	1.4	0.5	-0.5
Locomotion velocity, hab. session 1	0.7	1.1	2.0	-1.4	1.3	0.6	-0.5
Time in familiar zone, hab. session 2	0.6	0.6	1.6	-0.6	1.3	-0.4	0.4
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.3	-0.6	-0.2	0.2
Total zone transitions, hab. session 2	1.4	1.8	3.7	-1.9	1.8	-0.3	0.2
Total locomotion distance, hab. session 2	1.6	2.1	5.5	-2.3	1.2	0.9	-0.9
Locomotion velocity, hab. session 2	1.6	2.2	5.3	-2.3	0.9	1.2	-1.2
Novel to familiar place preference ratio	1.8	1.8	2.6	0.7	-1.3	1.6	-1.6
Novelty place preference	1.8	1.8	2.4	0.8	-1.4	1.5	-1.6
Time in novel zone, NPP test	1.3	1.4	2.0	0.6	-1.1	1.4	-1.4
Total zone transitions, NPP test	1.7	2.4	5.1	-2.3	2.1	-0.4	0.4
Total locomotion distance, NPP test	2.1	2.9	7.5	-2.7	1.8	0.5	-0.5
Locomotion velocity, NPP test	1.6	2.3	5.7	-2.4	1.5	0.7	-0.7
Pavlov. Cond. lever latency	2.6	3.3	8.1	-2.0	2.8	-0.8	0.8
Pavlov. Cond. magazine entry latency	1.9	2.4	3.4	1.3	-1.8	1.5	-1.5
Pavlov. Cond. change in total contacts	0.7	0.8	2.2	1.5	-0.9	0.2	-0.2
Pavlov. Cond. index score	2.9	3.7	6.3	1.1	-2.5	1.9	-1.9
Pavlov. Cond. latency score	2.9	3.7	7.6	1.5	-2.7	1.6	-1.6
Pavlov. Cond. lever contacts	1.4	1.7	4.1	1.1	-2.0	0.8	-0.8
Pavlov. Cond. magazine entry number	2.1	2.6	4.0	-1.9	2.0	-1.2	1.2
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.9	-1.4	0.6	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	5.6	1.1	-2.4	2.0	-1.9
Pavlov. Cond. response bias	2.2	2.7	4.8	1.6	-2.2	1.3	-1.3
Bone: apparent density	0.2	0.3	0.5	-0.7	0.1	0.6	-0.6
Bone surface	0.3	0.5	0.9	0.1	-0.9	0.7	-0.7
Bone volume	0.2	0.3	0.6	-0.4	-0.4	0.8	-0.7
Bone: connectivity density	0.1	0.2	0.7	-0.8	0.0	0.1	-0.1
Bone: cortical apparent density	2.1	2.7	4.4	0.7	1.2	-2.1	2.1
Bone: cortical area	4.6	7.0	11.6	-0.1	-2.3	3.4	-3.4
Bone: cortical porosity	2.0	2.1	4.8	2.2	-1.8	0.6	-0.6
Bone: cortical porosity	1.5	1.7	2.8	1.7	-1.5	0.9	-0.8
Bone: cortical thickness	3.9	6.4	9.2	0.7	-2.7	3.0	-3.0
Bone: cortical thickness	1.1	1.3	2.3	0.1	-0.8	1.5	-1.5
Bone: cortical tissue density	2.4	3.1	5.0	0.8	1.3	-2.2	2.2
Bone: elastic displacement	0.9	1.1	1.5	0.3	-1.1	1.2	-1.2
Bone: elastic work	4.9	6.4	8.5	1.3	-2.7	2.9	-2.9
Bone: endosteal estimation	0.4	0.9	2.0	-1.4	1.2	0.2	-0.3
Bone: endosteal perimeter	0.5	1.1	1.8	-0.2	-0.9	1.4	-1.3
Bone: final force	4.0	6.5	11.5	-0.6	-1.6	3.4	-3.4
Bone: final moment	4.5	7.4	13.0	-0.4	-1.8	3.6	-3.6
Bone: marrow area	0.4	0.9	2.0	-1.4	1.2	0.2	-0.2
Bone: maximum diameter	1.4	2.5	3.8	-0.1	-1.6	1.9	-1.9
Bone: maximum force	3.9	6.8	12.1	-0.8	-1.6	3.5	-3.5
Bone: maximum moment	4.4	7.6	13.5	-0.6	-1.8	3.7	-3.7
Bone: minimum diameter	2.4	4.4	7.8	-0.2	-1.5	2.8	-2.7
Bone: periosteal estimation	1.5	3.1	5.6	-0.9	-0.8	2.4	-2.3
Bone: periosteal perimeter	2.8	4.7	6.8	1.0	-2.6	2.4	-2.3
Bone: post-yield work	0.2	0.3	0.9	-1.0	0.6	0.1	-0.1
Bone: stiffness	0.6	0.9	1.7	-0.6	-0.4	1.3	-1.3
Bone: tissue strength	1.4	1.3	1.9	-1.2	-0.4	1.4	-1.4
Bone: trabecular number	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.1
Bone: trabecular spacing	2.2	2.8	7.1	-2.7	1.8	0.7	-0.7
Bone: trabecular thickness	1.1	1.3	3.0	1.7	-1.4	0.4	-0.4
Bone: trabecular tissue density	0.6	0.9	1.5	0.3	0.7	-1.2	1.2
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.6	0.3	0.6	-0.5
Distance traveled before self-admin	0.7	0.7	1.2	0.6	-0.5	1.1	-1.0
Distance traveled after self-admin	0.8	0.9	1.2	-1.1	0.9	0.9	-0.9
Delta time in closed arm before/after self-admin	0.9	0.8	3.2	0.0	-1.8	0.2	-0.2
Delta time in open arm before/after self-admin	0.9	0.9	2.5	-0.8	1.6	0.4	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.4	0.1	-0.4	0.5
Extinction: sum of active levers before priming	1.1	1.1	1.6	0.8	0.7	-1.2	1.3
Active lever presses in extinction session 6	0.3	0.3	0.9	1.0	0.4	-0.2	0.3
Delta distance traveled before/after self-admin	0.9	0.9	1.9	-1.3	1.4	-0.3	0.3
Delta ambulatory time before/after self-admin	0.9	1.0	1.7	-1.0	1.3	-0.9	0.8
Time in closed arm before self-admin	0.7	0.8	1.2	1.0	0.6	-1.1	1.0
Time in closed arm after self-admin	2.3	2.4	4.1	2.0	-1.3	-1.4	1.3
Time in open arm before self-admin	0.6	0.6	2.3	-0.1	-1.5	0.3	-0.3
Time in open arm after self-admin	0.3	0.4	0.7	-0.9	0.8	0.2	-0.1
Sum of active levers in priming session hrs 5-6	0.8	0.7	2.3	0.1	1.5	0.6	-0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.3	-0.1	0.3	-0.3
Time to tail flick, vehicle, after self-admin	1.3	1.3	2.6	0.4	0.1	-1.6	1.6
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.5	-0.7	0.0	-0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.4	-0.8	-0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.5	0.3	-0.3	0.4
Delta time to tail flick, test, before/after SA	0.4	0.3	0.5	0.7	-0.0	-0.6	0.7
Ambulatory time before self-admin	1.3	1.4	2.6	0.3	-0.6	1.6	-1.5
Ambulatory time after self-admin	0.5	0.5	0.7	-0.7	0.6	0.8	-0.8
Total heroin consumption	0.2	0.3	0.8	0.9	-0.0	0.4	-0.2
Area under the delay curve	1.5	1.6	2.2	0.3	1.4	-1.5	1.5
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.0	0.1	0.0	0.0
Delay disc. indifference point, 16s delay	1.9	1.9	4.8	-1.1	2.2	-0.9	0.9
Delay disc. indifference point, 2s delay	0.2	0.3	0.3	0.4	0.5	-0.6	0.6
Delay disc. indifference point, 24s delay	4.0	3.9	6.3	1.3	1.1	-2.5	2.5
Delay disc. indifference point, 4s delay	0.6	0.7	1.2	0.5	0.4	-1.1	1.0
Delay disc. indifference point, 8s delay	1.1	1.1	1.7	1.0	0.5	-1.3	1.3
Delay discount exponential model param	2.2	2.3	3.6	-0.6	-1.3	1.9	-1.9
Delay discount hyperbolic model param	2.1	2.2	3.4	-0.6	-1.4	1.8	-1.8
Fecal boli incidents, locomotor time 1	0.2	0.2	0.3	-0.2	0.5	-0.5	0.5
Change in fecal boli incidents, locomotor task	3.0	2.8	4.1	1.8	0.2	-2.0	2.0
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.5	-1.2	0.1	0.5	-0.5
Bouts of movement, locomotor time 1	1.8	2.0	3.4	0.5	1.0	-1.9	1.8
Total resting periods, locomotor time 1	2.4	2.7	4.8	0.9	0.7	-2.2	2.1
Rest time, locomotor task time 1	0.5	0.6	0.9	0.9	-0.4	-0.8	0.8
Distance moved, locomotor task time 1	0.6	0.6	1.0	-0.8	-0.0	1.0	-1.0
Vertical activity count, locomotor time 1	1.8	1.9	2.8	-1.5	0.0	1.7	-1.6
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.5	0.2	-1.2	-0.0	0.0
Bouts of movement, locomotor time 2	1.1	1.2	2.0	-0.1	1.1	-1.4	1.4
Total resting periods, locomotor time 2	0.7	0.8	1.1	-0.4	0.9	-1.1	1.0
Rest time, locomotor task time 2	0.3	0.3	0.5	0.4	-0.5	-0.7	0.6
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.2	-0.3	0.4	-0.4
Vertical activity count, locomotor time 2	0.6	0.6	1.3	-1.2	0.2	0.8	-0.7
Weight adjusted by age	2.4	2.7	5.0	-0.4	-0.9	2.2	-2.1
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	2.3	-0.5	-0.8	1.5	-1.5
Locomotion in novel chamber	0.2	0.2	0.5	-0.6	0.7	-0.1	0.1
Locomotion in novel chamber post-restriction	1.0	1.2	1.9	-0.1	-1.2	1.3	-1.4
Progressive ratio	0.1	0.2	0.2	0.2	0.5	-0.4	0.5
Food seeking constrained by brief footshock	0.3	0.3	0.7	0.8	0.1	-0.6	0.6
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.3	0.1	0.2	-0.2
Run reversals in cocaine runway, females	2.0	2.0	5.1	-1.1	2.3	-0.9	0.9
Run reversals in cocaine runway, males	1.5	1.5	3.0	1.1	-1.7	0.9	-0.9
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.4	0.6	-0.5	0.5
Latency to leave start box in cocaine runway, F	0.4	0.4	1.1	-1.1	0.6	-0.2	0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.4	-0.3	-0.3	0.2
Cd content in liver	1.9	2.0	3.4	-0.4	1.8	-1.5	1.5
Co content in liver	0.2	0.2	0.6	-0.3	0.7	-0.3	0.3
Cu content in liver	0.9	1.1	2.2	1.5	-1.4	0.3	-0.3
Fe content in liver	0.7	0.8	1.3	-0.2	0.9	-1.1	1.1
K content in liver	2.0	2.0	3.0	-1.2	-0.9	1.7	-1.7
Mg content in liver	0.9	0.9	2.9	-1.7	0.2	0.6	-0.6
Mn content in liver	0.4	0.5	1.1	0.3	-1.1	0.6	-0.6
Na content in liver	0.1	0.1	0.4	0.3	-0.6	0.1	-0.0
Rb content in liver	1.0	1.2	1.9	-1.4	0.2	1.2	-1.2
Se content in liver	0.3	0.3	0.5	-0.4	-0.2	0.7	-0.7
Sr content in liver	1.2	1.1	3.4	1.8	-0.7	-0.5	0.6
Zn content in liver	0.6	0.7	2.0	0.8	-1.4	-0.2	0.2