Sirt7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	intron excision ratio	chr10:105897165:105898265	0.32	0.17	2.4e-03	-0.01	0.08	-0.01	0.01	7.8e-01	6.8e-03	9.4e-01	1.9e-01
2	Liver	gene expression	ENSRNOG00000036683	0.03	0.02	1.8e-03	0.03	0.03	0.02	0.03	5.0e-04	6.0e-04	2.8e-03	8.0e-04
3	Liver	mRNA stability	ENSRNOG00000036683	0.17	0.1	4.7e-13	0.12	0.12	0.12	0.12	1.0e-13	6.2e-13	2.9e-13	2.3e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	0.1	0.2	0.6	0.7	-0.2	0.2
BMI without tail	0.9	1.8	5.0	2.2	-0.5	0.3
Body weight	1.0	4.4	6.7	-0.5	-2.6	2.5
Epididymis fat weight	0.1	0.2	0.3	0.6	-0.3	0.3
Glucose	1.9	2.9	7.0	-2.6	-0.9	0.9
Heart weight	0.2	0.2	0.4	-0.2	-0.6	0.6
Left kidney weight	0.2	0.7	1.0	-1.0	-0.7	0.8
Right kidney weight	0.0	0.0	0.1	-0.3	0.0	0.0
Tail length	0.8	2.3	3.5	0.8	-1.9	1.7
Length with tail	1.5	5.4	7.2	-1.4	-2.7	2.7
Length without tail	1.8	4.0	7.2	-2.7	-1.5	1.6
Liver weight, left	0.8	1.2	2.0	-1.4	-0.9	0.9
Liver weight, right	0.9	1.4	1.9	-0.8	-1.4	1.3
Parametrial fat weight	0.7	1.3	2.0	-0.4	-1.4	1.3
Retroperitoneal fat weight	1.2	3.9	6.1	-0.4	-2.3	2.5
Intraocular pressure	0.1	0.1	0.2	0.5	-0.2	0.2
Extensor digitorum longus weight	0.6	2.3	4.2	2.1	0.9	-1.3
Soleus weight	0.3	0.8	1.4	-0.0	-1.2	1.0
Tibialis anterior weight	0.2	0.5	1.0	1.0	0.4	-0.7
Tibia length	7.6	21.3	27.5	-3.3	-5.2	5.1
Number of licking bursts	0.2	0.2	0.4	0.6	0.4	-0.3
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.0	-0.4	0.4
Times rat made contact with spout	3.1	3.5	3.8	-1.7	-1.9	1.9
Mean time between licks in bursts	0.9	1.3	1.9	0.7	1.4	-1.3
Mean num. licks in bursts	1.4	1.7	1.8	-1.3	-1.3	1.3
Std. dev. time between licks in bursts	2.8	3.4	6.0	2.4	1.4	-1.5
Water consumed over 24 hours	0.7	0.8	1.3	-1.1	-0.7	0.7
Indifference point 0 sec	0.1	0.1	0.2	-0.1	-0.5	0.4
Indifference point AUC	0.1	0.1	0.1	0.4	0.2	-0.2
Indifference point function ln k	0.4	0.5	0.7	0.5	0.8	-0.8
Indifference point function log k	0.4	0.5	0.7	0.5	0.8	-0.8
Delay discounting total patch changes 0 sec	0.0	0.1	0.1	0.1	-0.3	0.3
Delay discounting total patch changes 12 sec	0.2	0.2	0.3	-0.4	-0.6	0.5
Delay discounting total patch changes 18 sec	0.5	0.7	1.1	1.1	0.6	-0.8
Delay discounting total patch changes 24 sec	0.1	0.2	0.3	0.1	-0.5	0.5
Delay discounting total patch changes 6 sec	0.6	0.9	1.2	-0.7	-1.1	1.0
Delay discounting time to switch 0 sec	0.1	0.1	0.2	-0.1	0.4	-0.4
Delay discounting water rate 0 sec	0.3	0.4	0.5	0.5	-0.7	0.7
Delay discounting water rate 12 sec	0.5	0.8	1.5	1.2	0.6	-0.7
Delay discounting water rate 18 sec	0.5	0.7	1.6	1.2	0.4	-0.5
Delay discounting water rate 24 sec	0.7	1.0	2.8	1.7	0.4	-0.3
Delay discounting water rate 6 sec	0.3	0.4	0.7	0.8	0.5	-0.6
Locomotor activity	0.2	0.3	0.4	0.1	0.6	-0.6
Locomotor testing distance	0.8	1.3	1.7	0.7	1.3	-1.3
Locomotor testing rearing	0.6	0.9	1.0	0.8	1.0	-1.0
Light reinforcement 1	0.3	0.6	1.6	1.3	0.4	-0.4
Light reinforcement 2	0.1	0.2	0.2	0.4	-0.4	0.4
Reaction time number correct	6.0	8.6	12.3	3.5	2.6	-2.6
Reaction time mean minus median	0.5	0.6	1.1	-1.1	-0.6	0.5
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.4	-0.2	0.1
Reaction time num false alarms	0.1	0.1	0.2	0.1	0.4	-0.2
Reaction time num false alarms AUC	0.4	0.5	0.8	0.4	0.9	-0.7
Reaction time trials correct on left	6.0	8.6	12.3	3.5	2.6	-2.6
Reaction time trials on left	6.3	8.9	12.7	3.6	2.6	-2.7
Reaction time mean	0.0	0.0	0.0	0.1	-0.2	0.1
Reaction time mean AUC	0.1	0.2	0.4	0.6	0.3	-0.3
Median of all reaction times	0.1	0.1	0.3	0.5	0.0	-0.1
Reaction time omissions	0.1	0.2	0.3	0.6	0.3	-0.2
Reaction time false alarm rate	0.6	0.8	1.8	-1.4	-0.5	0.7
Reaction time premature initiation rate	0.3	0.4	0.6	0.2	0.7	-0.8
Reaction time premature initiations	3.0	4.2	4.4	2.1	2.0	-2.1
Std. dev. reaction times	0.2	0.2	0.3	0.2	0.5	-0.6
Reaction time trials completed	6.3	8.9	12.7	3.6	2.6	-2.7
Reaction time trials AUC	6.1	8.7	12.4	3.5	2.6	-2.6
Social response proportion	0.7	0.7	0.9	0.8	0.9	-0.9
Social responses	0.2	0.3	0.3	0.5	0.6	-0.6
Social time	0.3	0.3	0.4	0.6	0.6	-0.6
Conditioned locomotion	0.4	0.5	0.5	0.7	-0.7	0.7
Cocaine response after cond. corrected	0.3	0.3	0.4	-0.6	-0.5	0.5
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.4	0.0	0.0
Cocaine response before conditioning	0.9	1.1	1.4	0.8	1.2	-1.2
Saline control response	0.9	1.2	1.9	-0.3	-1.4	1.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.2	-0.5	0.3
Condit. Reinf. active-inactive response ratio	1.5	1.5	2.2	-0.8	-1.5	1.3
Condit. Reinf. active responses	0.1	0.1	0.4	0.6	0.1	-0.2
Condit. Reinf. inactive responses	0.8	0.9	1.1	0.9	1.1	-1.0
Condit. Reinf. lever presses	0.3	0.4	0.9	0.9	0.3	-0.4
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	0.9	0.3	-0.4
Pavlov. Cond. lever latency	0.4	0.6	1.5	-1.2	-0.4	0.4
Pavlov. Cond. magazine entry latency	2.9	3.4	3.6	1.7	1.9	-1.9
Pavlov. Cond. change in total contacts	1.0	1.4	1.9	1.4	1.1	-1.1
Pavlov. Cond. index score	1.0	1.3	1.8	1.4	1.0	-1.0
Pavlov. Cond. latency score	1.2	1.5	2.2	1.5	1.1	-1.1
Pavlov. Cond. lever contacts	0.6	0.8	1.9	1.4	0.4	-0.5
Pavlov. Cond. magazine entry number	2.5	3.1	3.2	-1.7	-1.8	1.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.1	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.0	1.4	1.1	-1.1
Pavlov. Cond. response bias	0.8	1.1	2.0	1.4	0.8	-0.9
Conditioned reinforcement - actives	0.6	0.6	0.6	0.8	0.8	-0.8
Conditioned reinforcement - inactives	0.8	1.0	1.3	-0.5	-1.1	1.1
Conditioned locomotion	0.0	0.1	0.1	0.2	0.2	-0.3
Intermittent access intake day 1-15 change	0.8	0.8	1.2	-0.5	-1.1	1.0
Intermittent access intake escalation	0.4	0.4	0.6	-0.2	-0.8	0.7
Intermittent access intake escalation 2	3.4	3.4	4.0	-1.4	-2.0	2.0
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.0	-0.8	-1.4	1.4
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.5	-0.1	0.2
Intermitt. access escalation Index	0.6	0.6	1.1	1.1	0.6	-0.5
Intermittent access day 1 total infusions	0.0	0.1	0.1	0.1	-0.3	0.3
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.2	-0.4	0.4
Intermittent access terminal intake (last 3 days)	0.5	0.5	0.7	-0.2	-0.8	0.9
Intermittent access total infusions	0.1	0.1	0.1	0.2	-0.3	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	0.1	-0.1
Intermittent access day 15 total locomotion	0.3	0.3	0.5	-0.4	-0.7	0.6
Intermittent access total locomotion	0.1	0.1	0.1	-0.1	-0.4	0.4
Intermittent access standard deviation	1.5	1.6	2.4	-1.5	-1.1	1.1
Cocaine induced anxiety	8.7	10.0	11.9	-2.5	-3.4	3.4
Post-drug Anxiety	2.3	2.6	2.9	-1.4	-1.7	1.7
Baseline Anxiety	6.6	7.0	9.4	1.6	3.1	-3.0
Lifetime Intake	0.0	0.0	0.0	0.1	-0.1	0.1
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.0	-0.4	0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.1	-0.4	0.3
Progressive ratio test 1 active lever presses	0.1	0.2	0.2	0.1	-0.5	0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	0.1	-0.6	0.6
Progressive ratio test 1 inactive lever presses	0.4	0.5	0.7	0.2	-0.8	0.8
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.1	-0.4	0.4
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	-0.2	0.2
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.5	-0.4	-0.7	0.7
Total sessions with >9 infusions	0.3	0.4	0.5	0.4	0.7	-0.7
Short access day 1 total inactive lever presses	1.3	1.4	1.5	1.2	1.2	-1.2
Short access day 10 total inactive lever presses	2.2	2.4	3.4	-0.7	-1.9	1.8
Short access day 1 total infusions	0.6	0.7	1.0	0.1	1.0	-1.0
Short access day 10 total infusions	0.5	0.6	0.8	-0.5	-0.9	0.8
Short access total infusions	0.0	0.0	0.0	-0.0	0.0	-0.0
Short access day 1 locomotion	0.1	0.1	0.4	-0.6	-0.0	0.0
Short access day 10 total locomotion	0.7	0.7	1.3	-1.1	-0.7	0.7
Short access total locomotion	0.2	0.2	0.4	-0.7	-0.1	0.1
Compulsive drug intake	0.1	0.1	0.1	0.3	-0.2	0.2
One hour access (0.3 mA shock)	0.2	0.2	0.3	0.3	-0.5	0.5
One hour access (shock baseline)	0.1	0.1	0.2	0.5	0.3	-0.3
Number of responses in last shaping day	0.0	0.0	0.1	0.1	-0.2	0.3
Context. condit. distance diff. score	1.7	2.0	3.7	1.9	1.1	-1.1
Locomotion velocity, session 1	0.4	0.5	1.3	-1.2	0.0	-0.0
Locomotion distance, session 1	2.9	3.8	4.4	1.6	2.1	-2.1
Locomotion velocity, session 2	1.1	1.3	2.0	0.0	1.4	-1.4
Locomotion distance, session 2	1.3	1.8	1.9	1.4	1.3	-1.4
Locomotion velocity, session 3	0.2	0.2	0.3	-0.6	0.4	-0.4
Locomotion distance, session 3	0.9	1.0	1.5	0.3	1.2	-1.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.6	0.0	-0.0
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.2	0.2	-0.2
Locomotion velocity, session 7	0.4	0.5	0.6	0.4	0.8	-0.8
Locomotion distance, session 7	4.2	5.4	6.1	2.0	2.4	-2.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.0	-0.2	0.2
Stereotopy head waving duration, day 7	0.2	0.3	0.3	-0.4	-0.6	0.6
Locomotion velocity, session 8	2.2	2.7	2.9	1.7	1.6	-1.6
Locomotion distance, session 8	4.2	6.2	9.4	3.1	2.1	-2.2
Degree of sensitization distance	0.4	0.4	1.0	1.0	0.4	-0.4
Degree of sensitization stereotypy	0.1	0.1	0.1	0.1	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.0	-0.8	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	-0.0	-0.6	0.7
Condit. Reinf. active responses	0.7	0.8	1.2	0.1	-1.1	1.1
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.1	-0.5	0.5
Incentive salience index mean	0.2	0.3	0.4	0.2	-0.6	0.7
Condit. Reinf. lever presses	0.3	0.5	0.6	0.8	0.6	-0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.5	-0.3	0.3
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.4	0.2	-0.3
Total zone transitions, hab. session 1	0.5	0.7	0.8	0.8	0.8	-0.9
Total locomotion distance, hab. session 1	0.3	0.4	0.9	1.0	0.4	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.9	1.0	0.4	-0.4
Time in familiar zone, hab. session 2	0.3	0.3	0.3	0.6	0.6	-0.5
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.0	0.2	-0.2
Total zone transitions, hab. session 2	2.8	3.6	4.6	2.1	1.7	-1.8
Total locomotion distance, hab. session 2	1.9	2.5	4.4	2.1	1.2	-1.3
Locomotion velocity, hab. session 2	1.4	1.9	3.8	2.0	0.9	-1.0
Novel to familiar place preference ratio	3.8	4.0	4.8	-1.6	-2.1	2.2
Novelty place preference	3.9	4.0	4.8	-1.7	-2.1	2.2
Time in novel zone, NPP test	2.8	2.9	3.5	-1.4	-1.8	1.9
Total zone transitions, NPP test	4.0	5.7	6.8	2.6	2.2	-2.3
Total locomotion distance, NPP test	3.4	4.7	7.0	2.6	1.9	-1.9
Locomotion velocity, NPP test	2.0	2.8	4.6	2.2	1.4	-1.4
Pavlov. Cond. lever latency	3.3	4.2	4.7	2.2	2.0	-2.0
Pavlov. Cond. magazine entry latency	4.4	5.6	6.3	-2.1	-2.5	2.5
Pavlov. Cond. change in total contacts	2.8	2.9	3.4	-1.8	-1.7	1.6
Pavlov. Cond. index score	3.9	4.9	5.7	-1.9	-2.4	2.4
Pavlov. Cond. latency score	4.0	5.2	5.6	-2.1	-2.4	2.3
Pavlov. Cond. lever contacts	1.5	1.8	1.8	-1.3	-1.4	1.3
Pavlov. Cond. magazine entry number	5.7	7.2	7.6	2.6	2.8	-2.7
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.3	1.2	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	4.1	5.2	6.0	-1.9	-2.5	2.4
Pavlov. Cond. response bias	4.7	5.7	6.2	-2.3	-2.5	2.4
Bone: apparent density	0.1	0.1	0.3	0.5	0.1	-0.0
Bone surface	0.1	0.2	0.3	-0.3	-0.6	0.5
Bone volume	0.0	0.1	0.1	0.1	-0.4	0.3
Bone: connectivity density	0.6	0.9	1.1	1.1	0.9	-0.9
Bone: cortical apparent density	0.4	0.6	0.9	-0.0	0.9	-1.0
Bone: cortical area	3.7	5.7	7.7	-1.3	-2.7	2.8
Bone: cortical porosity	6.0	6.4	7.3	-2.7	-2.4	2.5
Bone: cortical porosity	4.8	5.2	5.3	-2.3	-2.2	2.3
Bone: cortical thickness	5.0	8.2	10.2	-2.1	-3.2	3.2
Bone: cortical thickness	1.5	1.8	2.4	-0.9	-1.5	1.6
Bone: cortical tissue density	0.5	0.7	1.1	-0.0	1.0	-1.0
Bone: elastic displacement	1.7	1.9	2.3	-1.0	-1.5	1.5
Bone: elastic work	9.7	12.6	15.0	-2.8	-3.9	3.9
Bone: endosteal estimation	0.5	1.1	1.7	1.3	0.9	-0.9
Bone: endosteal perimeter	0.3	0.7	0.9	-0.4	-1.0	0.9
Bone: final force	2.7	4.4	6.2	-1.0	-2.5	2.5
Bone: final moment	3.7	6.1	8.3	-1.3	-2.9	2.9
Bone: marrow area	0.5	1.1	1.7	1.3	0.9	-0.9
Bone: maximum diameter	0.7	1.3	1.8	-0.6	-1.3	1.3
Bone: maximum force	2.1	3.7	5.3	-0.7	-2.3	2.3
Bone: maximum moment	3.0	5.1	7.2	-1.0	-2.7	2.7
Bone: minimum diameter	2.1	3.9	5.3	-1.1	-2.3	2.3
Bone: periosteal estimation	0.6	1.1	1.7	-0.2	-1.3	1.3
Bone: periosteal perimeter	3.8	6.2	7.4	-2.0	-2.7	2.7
Bone: post-yield work	0.6	0.8	1.1	1.0	0.8	-0.9
Bone: stiffness	0.1	0.2	0.2	0.1	-0.5	0.5
Bone: tissue strength	0.2	0.2	0.4	0.6	-0.2	0.2
Bone: trabecular number	0.0	0.0	0.0	0.1	0.2	-0.1
Bone: trabecular spacing	2.4	3.0	5.2	2.3	1.4	-1.4
Bone: trabecular thickness	3.0	3.7	4.2	-2.0	-1.8	1.9
Bone: trabecular tissue density	0.3	0.4	0.7	0.2	0.8	-0.8
Breakpoint value in progressive ratio session	1.7	1.9	2.1	-1.3	-1.4	1.5
Distance traveled before self-admin	2.9	3.1	3.7	-1.5	-1.9	1.9
Distance traveled after self-admin	0.1	0.1	0.3	0.6	-0.1	0.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	0.5	0.7	-0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.4	0.2	-0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.4	0.1	-0.1
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.6	0.3	-0.3
Active lever presses in extinction session 6	1.0	1.0	1.6	-1.3	-0.8	0.8
Delta distance traveled before/after self-admin	2.1	2.3	2.5	1.6	1.5	-1.5
Delta ambulatory time before/after self-admin	2.9	3.2	3.5	1.6	1.9	-1.8
Time in closed arm before self-admin	0.7	0.8	1.0	-1.0	-0.8	0.8
Time in closed arm after self-admin	1.1	1.2	2.2	-1.5	-0.8	0.8
Time in open arm before self-admin	0.7	0.8	0.9	0.6	1.0	-1.0
Time in open arm after self-admin	0.8	0.9	0.9	0.9	1.0	-0.9
Sum of active levers in priming session hrs 5-6	1.9	1.8	2.3	-1.0	-1.5	1.5
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.3	0.1	-0.1
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.1	0.5	1.4	-1.4
Time to tail flick, test, before self-admin	0.3	0.3	0.3	-0.4	-0.6	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.1	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	1.2	0.9	1.1	-1.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.5	0.1	-0.1
Ambulatory time before self-admin	3.5	3.6	4.4	-1.4	-2.1	2.1
Ambulatory time after self-admin	0.0	0.1	0.1	0.2	-0.2	0.2
Total heroin consumption	1.3	1.5	2.0	-1.4	-1.1	1.1
Area under the delay curve	0.8	0.8	1.2	0.3	1.1	-1.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.1	0.3	-0.3
Delay disc. indifference point, 16s delay	3.8	3.8	4.4	1.6	2.1	-2.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.2	0.3	-0.3
Delay disc. indifference point, 24s delay	0.8	0.8	1.2	-0.3	1.1	-1.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.1	0.3	-0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.5	0.2	-0.2
Delay discount exponential model param	0.7	0.7	1.1	-0.1	-1.0	1.0
Delay discount hyperbolic model param	0.7	0.7	1.1	-0.1	-1.0	1.0
Fecal boli incidents, locomotor time 1	0.6	0.7	0.9	0.6	0.9	-0.9
Change in fecal boli incidents, locomotor task	0.7	0.7	1.7	-1.3	-0.5	0.5
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.6	1.3	0.7	-0.6
Bouts of movement, locomotor time 1	0.4	0.4	0.7	0.1	0.8	-0.8
Total resting periods, locomotor time 1	0.2	0.3	0.4	-0.2	0.6	-0.6
Rest time, locomotor task time 1	0.3	0.3	0.6	-0.8	-0.4	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	-0.0	0.1
Vertical activity count, locomotor time 1	0.4	0.4	1.0	1.0	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.2	0.3	-0.3
Bouts of movement, locomotor time 2	1.0	1.1	1.5	0.7	1.2	-1.2
Total resting periods, locomotor time 2	1.4	1.5	1.9	1.0	1.3	-1.4
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.1	0.2	-0.2
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.2	0.1	-0.1
Vertical activity count, locomotor time 2	0.9	1.0	1.2	1.1	0.9	-0.9
Weight adjusted by age	1.7	1.9	2.6	-0.7	-1.6	1.6
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	-0.0	-0.7	0.7
Locomotion in novel chamber	0.7	0.8	1.0	0.7	1.0	-1.0
Locomotion in novel chamber post-restriction	1.1	1.3	2.0	-0.4	-1.4	1.4
Progressive ratio	0.1	0.1	0.2	0.0	0.5	-0.5
Food seeking constrained by brief footshock	0.3	0.3	0.6	-0.8	-0.4	0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.1	-0.2	0.2
Run reversals in cocaine runway, females	1.7	1.7	1.7	1.3	1.3	-1.3
Run reversals in cocaine runway, males	3.2	3.1	3.4	-1.6	-1.8	1.8
Latency to leave start box in cocaine runway	0.4	0.5	0.5	0.7	0.7	-0.7
Latency to leave start box in cocaine runway, F	1.8	2.0	2.0	1.4	1.4	-1.4
Latency to leave start box in cocaine runway, M	0.3	0.3	0.3	-0.4	-0.6	0.5
Cd content in liver	1.2	1.3	1.7	0.8	1.3	-1.3
Co content in liver	0.1	0.1	0.1	0.2	0.2	-0.2
Cu content in liver	2.0	2.4	3.0	-1.7	-1.4	1.5
Fe content in liver	0.6	0.8	1.0	0.6	1.0	-1.0
K content in liver	0.2	0.2	0.5	0.7	-0.1	0.3
Mg content in liver	2.1	2.1	3.2	1.8	1.4	-1.2
Mn content in liver	0.1	0.2	0.2	-0.3	-0.4	0.5
Na content in liver	0.0	0.0	0.0	-0.2	-0.0	0.1
Rb content in liver	0.3	0.4	1.0	1.0	0.4	-0.2
Se content in liver	0.0	0.0	0.0	0.2	-0.1	0.2
Sr content in liver	2.2	2.0	3.2	-1.8	-1.2	1.2
Zn content in liver	0.0	0.1	0.1	-0.4	0.1	0.1