Sectm1b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000036673	0.11	0.06	1.0e-09	0.07	0.08	0.08	0.08	4.1e-08	5.8e-09	2.8e-09	1.7e-09
2	Liver	gene expression	ENSRNOG00000036673	0.52	0.11	0.0e+00	0.34	0.48	0.48	0.48	1.4e-38	2.4e-60	6.3e-61	4.9e-61
3	Liver	intron excision ratio	chr10:106325788:106325996	0.04	0.02	1.9e-03	0	0.02	0.01	0.01	7.3e-02	1.9e-03	2.9e-02	1.4e-02
4	Liver	intron excision ratio	chr10:106325788:106326353	0.06	0.04	1.7e-06	0.04	0.05	0.04	0.06	8.9e-05	2.6e-06	9.0e-06	9.2e-07
5	Liver	intron excision ratio	chr10:106326055:106326353	0.08	0.04	1.4e-09	0.04	0.08	0.07	0.08	8.1e-06	3.0e-09	1.4e-08	7.3e-09
6	Liver	mRNA stability	ENSRNOG00000036673	0.05	0.03	2.0e-05	0.01	0.03	0.03	0.03	1.8e-02	9.8e-05	2.6e-04	6.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	0.2	0.6	2.5	1.6	0.5	0.0	-0.1	0.6	-0.6
BMI without tail	7.8	16.2	20.4	4.5	1.9	4.1	-4.1	4.4	-4.5
Body weight	1.1	4.6	10.5	3.2	-0.1	1.2	-1.6	2.5	-2.6
Epididymis fat weight	0.7	1.7	2.9	1.7	0.9	1.2	-1.0	1.4	-1.5
Glucose	8.6	13.1	16.6	-4.1	-3.0	-3.9	3.6	-3.6	3.5
Heart weight	0.2	0.3	1.0	0.7	-1.0	-0.3	-0.1	0.2	-0.1
Left kidney weight	0.3	1.0	2.1	-0.3	-0.9	-1.4	1.2	-0.9	0.9
Right kidney weight	0.3	0.9	1.8	-0.1	-0.1	-1.3	1.3	-0.9	1.0
Tail length	6.2	18.8	26.1	4.3	1.1	4.5	-4.7	4.9	-5.1
Length with tail	0.6	2.2	3.8	1.7	-0.6	1.0	-1.3	1.8	-2.0
Length without tail	4.0	8.7	13.3	-2.4	-2.0	-3.7	3.5	-3.0	2.9
Liver weight, left	1.2	2.0	2.5	-1.3	-1.5	-1.6	1.5	-1.3	1.3
Liver weight, right	0.4	0.7	1.3	1.1	-0.5	0.5	-0.7	1.0	-1.0
Parametrial fat weight	1.0	2.0	3.0	1.5	-0.3	1.3	-1.7	1.6	-1.7
Retroperitoneal fat weight	2.9	9.6	13.0	3.4	0.0	2.9	-3.4	3.5	-3.6
Intraocular pressure	1.0	1.4	2.0	1.1	0.4	1.3	-1.3	1.4	-1.4
Extensor digitorum longus weight	0.6	2.5	3.7	1.9	1.9	1.6	-1.3	1.4	-1.2
Soleus weight	1.2	3.5	4.6	2.2	0.1	1.8	-2.1	2.1	-2.1
Tibialis anterior weight	0.4	1.4	1.9	1.2	0.9	1.4	-1.3	1.2	-1.1
Tibia length	1.7	4.7	10.5	2.5	-3.2	0.1	-1.4	2.2	-2.2
Number of licking bursts	0.6	0.7	0.9	0.9	0.8	0.9	-0.8	0.8	-0.7
Food consumed during 24 hour testing period	0.6	0.7	1.1	0.8	0.1	0.9	-1.0	0.9	-0.9
Times rat made contact with spout	1.2	1.4	3.9	0.0	-2.0	0.7	-1.5	0.9	-1.0
Mean time between licks in bursts	0.8	1.1	1.4	-1.1	0.8	-0.7	1.2	-1.2	1.2
Mean num. licks in bursts	0.4	0.5	2.8	-0.6	-1.7	-0.2	-0.3	0.0	-0.1
Std. dev. time between licks in bursts	3.3	3.9	6.7	2.2	2.6	2.0	-1.4	1.7	-1.7
Water consumed over 24 hours	0.3	0.4	1.1	-0.7	-1.0	-0.5	0.2	-0.4	0.5
Indifference point 0 sec	0.0	0.0	0.1	-0.0	0.0	0.2	-0.2	0.2	-0.3
Indifference point AUC	0.2	0.2	0.5	0.4	0.1	0.6	-0.7	0.5	-0.5
Indifference point function ln k	0.9	1.3	2.1	-0.8	0.7	-1.0	1.5	-1.2	1.3
Indifference point function log k	0.9	1.3	2.1	-0.8	0.7	-1.0	1.5	-1.2	1.3
Delay discounting total patch changes 0 sec	0.0	0.1	0.1	0.1	0.2	0.3	-0.2	0.3	-0.3
Delay discounting total patch changes 12 sec	0.1	0.1	0.3	-0.2	-0.5	0.1	-0.3	0.2	-0.2
Delay discounting total patch changes 18 sec	0.2	0.3	0.7	0.4	0.8	0.7	-0.5	0.4	-0.4
Delay discounting total patch changes 24 sec	0.3	0.4	0.6	0.6	0.1	0.6	-0.6	0.7	-0.8
Delay discounting total patch changes 6 sec	0.2	0.3	0.4	0.2	-0.5	0.4	-0.6	0.6	-0.6
Delay discounting time to switch 0 sec	0.2	0.3	0.6	-0.8	-0.0	-0.4	0.5	-0.7	0.6
Delay discounting water rate 0 sec	1.3	2.1	3.3	1.7	0.6	1.3	-1.2	1.7	-1.8
Delay discounting water rate 12 sec	0.2	0.4	0.9	0.9	0.9	0.2	0.1	0.4	-0.4
Delay discounting water rate 18 sec	0.9	1.2	2.3	1.5	1.3	0.9	-0.6	1.0	-1.0
Delay discounting water rate 24 sec	1.9	2.6	4.5	2.1	1.4	1.4	-1.1	1.6	-1.7
Delay discounting water rate 6 sec	0.2	0.3	0.8	0.4	0.9	-0.4	0.7	-0.2	0.1
Locomotor activity	0.5	0.8	1.2	-1.0	-0.1	-0.8	1.0	-1.1	1.1
Locomotor testing distance	0.4	0.7	1.0	-0.7	0.7	-0.5	1.0	-0.9	1.0
Locomotor testing rearing	0.1	0.1	0.6	-0.3	0.7	0.3	0.0	-0.2	0.1
Light reinforcement 1	1.9	3.5	4.8	2.2	1.3	2.0	-1.8	1.9	-1.9
Light reinforcement 2	1.7	2.2	3.5	1.9	0.7	1.4	-1.4	1.6	-1.6
Reaction time number correct	3.4	4.8	10.3	2.5	3.2	2.2	-1.5	1.7	-1.6
Reaction time mean minus median	0.5	0.6	0.8	-0.8	-0.9	-0.8	0.6	-0.8	0.7
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.2	-0.2	0.2
Reaction time num false alarms	0.1	0.1	0.2	-0.3	-0.2	-0.2	0.2	-0.4	0.4
Reaction time num false alarms AUC	0.1	0.2	0.3	-0.5	0.1	-0.2	0.3	-0.5	0.6
Reaction time trials correct on left	3.4	4.8	10.3	2.5	3.2	2.2	-1.5	1.7	-1.6
Reaction time trials on left	3.5	5.0	10.7	2.5	3.3	2.2	-1.6	1.7	-1.6
Reaction time mean	0.2	0.3	0.6	0.8	-0.1	0.5	-0.7	0.6	-0.6
Reaction time mean AUC	0.5	0.6	1.3	1.1	0.4	0.8	-0.8	0.7	-0.7
Median of all reaction times	0.4	0.5	1.0	1.0	0.2	0.6	-0.8	0.7	-0.7
Reaction time omissions	0.4	0.5	0.6	0.7	0.7	0.8	-0.7	0.6	-0.6
Reaction time false alarm rate	1.3	1.8	2.6	-1.6	-1.5	-1.3	1.0	-1.3	1.3
Reaction time premature initiation rate	0.4	0.6	1.1	-1.1	-0.0	-0.6	0.6	-0.9	0.9
Reaction time premature initiations	0.5	0.7	3.0	0.4	1.7	0.7	-0.3	0.2	-0.1
Std. dev. reaction times	0.1	0.1	0.2	-0.2	0.0	-0.2	0.2	-0.4	0.5
Reaction time trials completed	3.5	5.0	10.7	2.5	3.3	2.2	-1.6	1.7	-1.6
Reaction time trials AUC	3.5	5.0	10.3	2.5	3.2	2.2	-1.6	1.8	-1.7
Social response proportion	0.5	0.5	0.9	-0.6	0.8	-0.6	1.0	-0.7	0.7
Social responses	0.4	0.5	1.0	-0.3	1.0	-0.5	0.9	-0.6	0.6
Social time	0.2	0.2	0.5	-0.0	0.5	-0.4	0.7	-0.4	0.5
Conditioned locomotion	4.7	5.6	7.4	2.7	0.7	2.3	-2.5	2.7	-2.7
Cocaine response after cond. corrected	0.4	0.5	0.9	-1.0	-0.5	-0.7	0.7	-0.6	0.6
Cocaine response after cond. not corrected	0.8	0.8	1.5	-1.2	-0.1	-0.9	1.1	-0.9	0.9
Cocaine response before conditioning	0.3	0.4	1.2	-0.3	1.1	-0.1	0.6	-0.5	0.5
Saline control response	2.0	2.6	4.0	1.7	0.0	1.6	-1.6	1.9	-2.0
Condit. Reinf. active minus inactive responses	0.5	0.7	1.3	1.1	-0.0	0.6	-0.7	1.0	-0.9
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.2	1.0	-1.0	0.5	-0.9	1.1	-1.1
Condit. Reinf. active responses	0.3	0.4	0.7	0.8	0.3	0.5	-0.5	0.7	-0.7
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.3	0.7	-0.3	0.6	-0.5	0.5
Condit. Reinf. lever presses	0.6	0.8	1.0	1.0	0.8	0.9	-0.8	0.9	-0.9
Condit. Reinf. lever reinforcers received	0.4	0.6	1.0	1.0	0.5	0.7	-0.7	0.8	-0.8
Pavlov. Cond. lever latency	1.5	2.1	2.6	-1.6	-0.9	-1.5	1.5	-1.5	1.4
Pavlov. Cond. magazine entry latency	0.4	0.5	2.5	-0.2	1.6	0.4	0.2	-0.3	0.3
Pavlov. Cond. change in total contacts	0.3	0.4	1.4	0.5	1.2	0.6	-0.3	0.3	-0.3
Pavlov. Cond. index score	0.4	0.5	1.4	0.5	1.2	0.8	-0.6	0.5	-0.5
Pavlov. Cond. latency score	0.6	0.8	1.6	0.7	1.3	1.0	-0.7	0.6	-0.6
Pavlov. Cond. lever contacts	2.3	3.2	3.9	2.0	1.1	1.9	-1.9	1.8	-1.8
Pavlov. Cond. magazine entry number	0.5	0.6	3.3	0.0	-1.8	-0.5	-0.1	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.2	1.5	-0.2	1.0	-1.3	1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.5	0.4	1.2	0.8	-0.5	0.4	-0.4
Pavlov. Cond. response bias	0.8	1.2	1.5	1.1	1.2	1.2	-1.0	1.0	-1.0
Conditioned reinforcement - actives	0.5	0.5	1.1	0.7	1.0	0.7	-0.6	0.6	-0.5
Conditioned reinforcement - inactives	0.3	0.4	0.7	0.5	-0.3	0.4	-0.7	0.7	-0.9
Conditioned locomotion	0.2	0.2	0.5	0.4	0.4	0.4	-0.7	0.3	-0.3
Intermittent access intake day 1-15 change	0.7	0.7	1.3	0.5	-0.2	0.9	-1.0	0.9	-1.1
Intermittent access intake escalation	1.0	1.0	1.6	0.6	0.2	1.1	-1.2	1.1	-1.3
Intermittent access intake escalation 2	0.5	0.5	1.9	0.3	-1.4	0.2	-0.5	0.6	-0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.4	0.1	-0.4	0.1	-0.3	0.4	-0.6
Intermitt. access day 15 inactive lever presses	1.1	1.2	1.6	1.2	0.5	1.1	-1.1	1.2	-1.3
Intermitt. access escalation Index	3.0	2.7	3.4	1.5	1.3	1.9	-1.8	1.7	-1.6
Intermittent access day 1 total infusions	0.5	0.6	1.2	0.8	0.3	0.6	-1.1	0.8	-0.7
Intermittent access day 15 total infusions	1.3	1.4	2.7	1.1	0.4	1.2	-1.6	1.2	-1.3
Intermittent access terminal intake (last 3 days)	1.4	1.5	3.0	1.0	0.1	1.2	-1.7	1.3	-1.4
Intermittent access total infusions	1.0	1.1	1.9	1.0	0.6	1.0	-1.4	1.1	-1.1
Intermittent access day 1 locomotion	0.4	0.4	0.9	0.5	1.0	0.5	-0.6	0.6	-0.6
Intermittent access day 15 total locomotion	0.3	0.3	0.8	0.3	-0.1	0.5	-0.9	0.6	-0.7
Intermittent access total locomotion	0.2	0.3	0.4	0.3	0.5	0.4	-0.6	0.5	-0.6
Intermittent access standard deviation	2.5	2.7	3.5	-1.7	-1.2	-1.9	1.8	-1.7	1.5
Cocaine induced anxiety	1.3	1.5	7.8	-0.1	-2.8	-1.0	0.4	-0.1	-0.2
Post-drug Anxiety	0.9	1.0	2.7	-0.9	-1.6	-1.2	0.8	-0.7	0.5
Baseline Anxiety	2.1	2.2	3.1	-1.6	1.8	-0.8	1.2	-1.6	1.8
Lifetime Intake	0.4	0.5	1.0	0.5	0.5	0.7	-1.0	0.6	-0.6
Incentive Sensitization - Responses	0.8	0.8	1.8	0.5	-0.3	0.9	-1.4	1.0	-1.0
Incentive Sensitization - Breakpoint	0.6	0.6	1.5	0.4	-0.4	0.8	-1.2	0.8	-0.8
Progressive ratio test 1 active lever presses	1.4	1.5	2.2	1.1	0.6	1.2	-1.5	1.3	-1.4
Progressive ratio test 1 breakpoint	1.8	1.9	2.7	1.3	0.4	1.4	-1.7	1.5	-1.5
Progressive ratio test 1 inactive lever presses	1.6	1.8	2.4	1.6	0.5	1.2	-1.4	1.5	-1.6
Progressive ratio test 2 active lever presses	0.6	0.7	1.5	0.5	0.1	0.8	-1.2	0.9	-0.9
Progressive ratio test 2 breakpoint	1.0	1.2	2.0	0.8	0.4	1.2	-1.4	1.2	-1.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.2	-0.3	0.2	-0.4	0.4	-0.5
Total sessions with >9 infusions	0.1	0.1	0.6	-0.2	0.8	-0.1	-0.2	-0.3	0.3
Short access day 1 total inactive lever presses	0.5	0.6	1.8	0.6	1.4	0.8	-0.3	0.5	-0.5
Short access day 10 total inactive lever presses	0.9	1.0	2.2	0.9	-0.6	0.7	-0.6	1.3	-1.5
Short access day 1 total infusions	1.2	1.3	2.0	-1.2	0.3	-1.1	0.9	-1.4	1.4
Short access day 10 total infusions	0.5	0.5	1.6	0.4	-0.1	0.5	-1.3	0.6	-0.7
Short access total infusions	0.1	0.1	0.3	0.1	0.2	0.2	-0.6	0.1	-0.1
Short access day 1 locomotion	0.9	1.0	1.5	-0.9	-0.6	-1.2	0.7	-1.2	1.2
Short access day 10 total locomotion	0.9	0.9	1.4	-1.2	-0.7	-1.2	0.7	-1.0	0.9
Short access total locomotion	0.8	0.8	1.1	-1.0	-0.3	-1.1	0.6	-1.0	1.0
Compulsive drug intake	0.2	0.2	0.5	0.7	0.2	0.4	-0.2	0.6	-0.6
One hour access (0.3 mA shock)	2.2	2.5	3.8	1.5	0.4	1.6	-2.0	1.8	-1.8
One hour access (shock baseline)	1.2	1.4	2.5	1.0	0.8	1.3	-1.6	1.1	-1.1
Number of responses in last shaping day	0.1	0.1	0.4	0.6	0.3	0.1	-0.3	0.4	-0.4
Context. condit. distance diff. score	2.6	3.2	4.2	2.0	1.7	1.9	-1.7	1.7	-1.6
Locomotion velocity, session 1	3.6	3.9	5.1	-2.3	-1.5	-2.0	1.8	-2.0	2.1
Locomotion distance, session 1	0.7	0.9	1.8	-0.4	1.3	-0.5	0.9	-1.0	1.1
Locomotion velocity, session 2	3.4	3.9	5.4	-2.2	0.1	-1.8	2.3	-2.3	2.3
Locomotion distance, session 2	0.2	0.3	1.6	0.5	1.3	0.2	0.1	0.0	0.1
Locomotion velocity, session 3	2.9	3.3	4.2	-1.9	-0.4	-1.9	2.0	-2.0	2.0
Locomotion distance, session 3	3.1	3.4	4.7	-1.8	0.5	-1.8	2.2	-2.1	2.1
Stereotopy head waving bouts, day 3	0.9	1.1	1.4	-1.0	-0.7	-1.1	1.0	-1.1	1.2
Stereotopy head waving duration, day 3	0.3	0.4	0.6	-0.5	-0.4	-0.7	0.6	-0.7	0.8
Locomotion velocity, session 7	0.3	0.3	0.5	-0.5	0.5	-0.4	0.5	-0.7	0.7
Locomotion distance, session 7	0.7	0.9	3.8	-0.4	1.9	-0.1	0.6	-0.8	0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.5	-0.1	0.1	-0.2	0.2	-0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.5	-0.3	0.1	-0.2	0.3	-0.3
Locomotion velocity, session 8	0.4	0.5	2.4	0.6	1.5	0.3	0.1	0.1	-0.0
Locomotion distance, session 8	2.9	4.4	7.8	2.5	2.8	2.1	-1.6	1.7	-1.6
Degree of sensitization distance	2.2	2.3	3.0	1.5	0.7	1.7	-1.7	1.6	-1.6
Degree of sensitization stereotypy	0.2	0.2	0.5	0.7	0.1	0.3	-0.4	0.5	-0.5
Condit. Reinf. active minus inactive responses	1.7	1.9	2.6	1.5	-0.1	1.2	-1.5	1.6	-1.6
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	0.9	-0.1	0.5	-0.7	0.8	-0.8
Condit. Reinf. active responses	3.7	4.5	6.2	2.3	0.0	2.0	-2.3	2.4	-2.5
Condit. Reinf. inactive responses	1.5	1.7	2.4	1.2	0.1	1.4	-1.5	1.5	-1.6
Incentive salience index mean	1.7	2.0	2.7	1.6	0.3	1.4	-1.5	1.6	-1.6
Condit. Reinf. lever presses	0.4	0.6	1.2	0.6	1.1	0.9	-0.6	0.6	-0.6
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.5	-0.8	-0.6	0.5	-0.4	0.4
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.4	0.6	0.4	-0.3	0.3	-0.3
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.0	0.5	-0.3	0.5	-0.4	0.5
Total locomotion distance, hab. session 1	0.3	0.4	1.0	1.0	0.8	0.5	-0.5	0.5	-0.4
Locomotion velocity, hab. session 1	0.3	0.5	1.1	1.0	0.8	0.6	-0.6	0.6	-0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.2	0.5	0.1	0.1	-0.1	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.1	0.0	-0.4	0.4	-0.3	0.3
Total zone transitions, hab. session 2	0.9	1.2	3.0	1.3	1.7	1.0	-0.7	0.8	-0.6
Total locomotion distance, hab. session 2	2.6	3.4	5.0	2.2	1.9	1.9	-1.7	1.7	-1.6
Locomotion velocity, hab. session 2	2.7	3.6	5.5	2.3	1.8	1.9	-1.8	1.8	-1.7
Novel to familiar place preference ratio	0.6	0.6	2.7	0.3	-1.6	-0.2	-0.3	0.5	-0.6
Novelty place preference	0.6	0.6	2.8	0.3	-1.7	-0.3	-0.2	0.4	-0.5
Time in novel zone, NPP test	0.4	0.4	2.0	0.3	-1.4	-0.2	-0.2	0.4	-0.5
Total zone transitions, NPP test	1.3	1.9	5.8	1.3	2.4	1.4	-0.9	0.8	-0.7
Total locomotion distance, NPP test	2.6	3.6	6.4	2.1	2.5	2.0	-1.5	1.6	-1.4
Locomotion velocity, NPP test	2.1	3.0	4.2	1.9	2.1	1.8	-1.5	1.5	-1.4
Pavlov. Cond. lever latency	0.5	0.6	3.2	0.5	1.8	0.5	-0.0	0.1	-0.0
Pavlov. Cond. magazine entry latency	0.6	0.8	3.9	-0.1	-2.0	-0.2	-0.3	0.4	-0.6
Pavlov. Cond. change in total contacts	1.1	1.2	2.8	-1.2	-1.7	-1.1	0.8	-0.7	0.7
Pavlov. Cond. index score	0.7	0.9	2.5	0.5	-1.6	0.3	-0.8	0.9	-1.0
Pavlov. Cond. latency score	0.6	0.7	3.1	0.1	-1.8	0.0	-0.6	0.6	-0.7
Pavlov. Cond. lever contacts	0.1	0.2	0.9	-0.0	-0.9	-0.0	-0.2	0.2	-0.3
Pavlov. Cond. magazine entry number	1.0	1.3	6.5	0.7	2.6	0.8	-0.1	0.0	0.1
Pavlov. Cond. intertrial magazine entries	1.3	1.6	1.8	1.4	1.0	1.3	-1.3	1.2	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.5	0.4	-1.6	0.2	-0.7	0.8	-0.9
Pavlov. Cond. response bias	0.6	0.8	4.1	-0.4	-2.0	-0.5	0.0	0.1	-0.3
Bone: apparent density	0.3	0.5	0.9	1.0	0.5	0.7	-0.8	0.7	-0.7
Bone surface	0.3	0.6	1.1	0.7	-0.1	0.8	-1.1	0.8	-0.8
Bone volume	0.4	0.7	1.1	0.9	0.1	0.9	-1.1	0.9	-0.9
Bone: connectivity density	0.6	0.9	1.4	1.0	1.2	1.1	-0.9	0.8	-0.7
Bone: cortical apparent density	2.1	2.8	3.7	-1.9	-0.2	-1.6	1.8	-1.9	1.9
Bone: cortical area	0.8	1.2	3.7	1.9	-1.2	-0.4	-0.2	1.0	-1.0
Bone: cortical porosity	2.1	2.3	7.2	-1.4	-2.7	-1.5	0.9	-0.9	0.8
Bone: cortical porosity	1.2	1.3	5.6	-0.8	-2.4	-1.1	0.5	-0.5	0.4
Bone: cortical thickness	0.9	1.4	4.1	1.2	-2.0	-1.5	0.8	0.1	-0.1
Bone: cortical thickness	0.4	0.5	1.2	0.5	-1.0	-1.1	0.7	-0.2	0.2
Bone: cortical tissue density	2.3	3.0	4.2	-2.0	-0.2	-1.6	1.8	-2.0	2.0
Bone: elastic displacement	0.3	0.3	1.0	0.5	-1.0	0.0	-0.4	0.5	-0.5
Bone: elastic work	1.4	1.8	8.3	0.8	-2.9	-0.6	-0.5	0.8	-0.8
Bone: endosteal estimation	0.5	1.1	1.6	0.9	1.2	1.3	-1.0	0.9	-0.9
Bone: endosteal perimeter	0.5	1.0	1.4	0.9	-0.2	1.0	-1.2	1.1	-1.2
Bone: final force	0.8	1.4	4.1	2.0	-0.9	-0.1	-0.5	1.2	-1.2
Bone: final moment	1.0	1.6	4.1	2.0	-1.3	-0.1	-0.6	1.3	-1.3
Bone: marrow area	0.5	1.0	1.5	0.9	1.2	1.2	-0.9	0.9	-0.9
Bone: maximum diameter	0.3	0.5	1.5	1.2	-0.3	0.1	-0.3	0.7	-0.7
Bone: maximum force	1.1	1.9	5.5	2.4	-0.8	0.2	-0.8	1.5	-1.5
Bone: maximum moment	1.2	2.1	5.5	2.3	-1.1	0.2	-0.9	1.6	-1.6
Bone: minimum diameter	0.7	1.3	2.3	1.5	-0.9	0.5	-1.0	1.3	-1.3
Bone: periosteal estimation	0.6	1.2	3.1	1.8	-0.1	0.6	-0.8	1.2	-1.2
Bone: periosteal perimeter	0.5	0.8	3.1	0.7	-1.8	-0.4	-0.2	0.6	-0.7
Bone: post-yield work	0.2	0.3	1.0	0.6	1.0	0.4	-0.1	0.3	-0.3
Bone: stiffness	0.2	0.3	0.9	1.0	0.1	-0.5	0.5	0.1	-0.1
Bone: tissue strength	1.0	1.0	2.5	1.6	0.7	0.7	-0.7	1.0	-1.0
Bone: trabecular number	0.1	0.1	0.3	0.4	0.1	0.4	-0.5	0.4	-0.3
Bone: trabecular spacing	2.1	2.7	5.4	1.8	2.3	1.7	-1.1	1.3	-1.3
Bone: trabecular thickness	1.0	1.2	4.9	-0.9	-2.2	-1.0	0.4	-0.5	0.4
Bone: trabecular tissue density	0.5	0.7	1.0	-1.0	0.2	-0.7	0.9	-1.0	1.0
Breakpoint value in progressive ratio session	0.7	0.7	1.2	-0.7	-0.9	-1.1	1.0	-0.8	0.5
Distance traveled before self-admin	0.4	0.4	2.1	0.0	-1.4	-0.4	-0.0	0.0	-0.1
Distance traveled after self-admin	1.5	1.7	2.6	1.0	0.5	1.6	-1.4	1.4	-1.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.9	0.1	0.9	0.4	-0.1	0.2	-0.2
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.1	0.0
Diff in mean of infusions in LGA sessions	0.6	0.7	1.6	-0.8	0.2	-0.6	1.3	-0.8	0.7
Extinction: sum of active levers before priming	3.2	3.3	4.3	-1.5	-1.0	-2.1	1.9	-2.0	2.1
Active lever presses in extinction session 6	4.1	3.9	5.6	-1.8	-1.2	-2.4	2.2	-2.1	1.9
Delta distance traveled before/after self-admin	0.8	0.9	2.2	0.4	1.5	1.2	-0.6	0.7	-0.7
Delta ambulatory time before/after self-admin	0.7	0.7	2.8	-0.0	1.7	1.1	-0.4	0.3	-0.3
Time in closed arm before self-admin	0.7	0.8	1.3	-0.7	-1.0	-1.1	0.7	-0.9	0.9
Time in closed arm after self-admin	2.0	2.1	3.1	-1.7	-1.0	-1.6	1.4	-1.4	1.4
Time in open arm before self-admin	0.2	0.2	0.5	0.4	0.7	0.5	-0.3	0.3	-0.1
Time in open arm after self-admin	0.0	0.1	0.2	0.3	0.4	0.2	-0.1	0.0	0.0
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.4	-0.4	-1.2	-0.5	0.0	-0.2	-0.0
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.7	-0.0	0.6	-0.7	0.6	-0.5
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.3	-1.0	0.6	-1.0	1.5	-1.3	1.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	0.1	0.3	-0.2	0.3	-0.4
Time to tail flick, test, after self-admin	0.6	0.6	0.9	-0.9	0.2	-0.7	0.9	-0.9	0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	1.0	-0.1	1.0	0.3	0.2	-0.0	0.1
Delta time to tail flick, test, before/after SA	2.1	1.9	2.6	-1.1	-0.7	-1.6	1.6	-1.5	1.5
Ambulatory time before self-admin	0.5	0.5	2.1	0.5	-1.5	-0.3	-0.3	0.3	-0.4
Ambulatory time after self-admin	0.4	0.5	0.8	0.6	0.1	0.9	-0.7	0.8	-0.9
Total heroin consumption	2.5	3.0	4.8	-1.0	-1.4	-2.2	2.2	-1.7	1.6
Area under the delay curve	1.0	1.1	1.5	-1.1	0.5	-0.9	1.2	-1.2	1.2
Delay disc. indifference point, 0s delay	0.2	0.3	0.6	-0.2	0.1	-0.6	0.8	-0.5	0.6
Delay disc. indifference point, 16s delay	0.6	0.6	2.9	-0.3	1.7	0.1	0.4	-0.5	0.5
Delay disc. indifference point, 2s delay	0.5	0.5	0.7	-0.8	-0.2	-0.8	0.8	-0.8	0.8
Delay disc. indifference point, 24s delay	4.4	4.2	6.0	-2.3	-0.3	-2.1	2.0	-2.4	2.5
Delay disc. indifference point, 4s delay	0.5	0.5	1.1	-0.7	0.2	-0.7	1.1	-0.7	0.7
Delay disc. indifference point, 8s delay	1.4	1.4	1.9	-1.3	-0.2	-1.3	1.4	-1.3	1.3
Delay discount exponential model param	1.7	1.8	2.3	1.5	-0.3	1.2	-1.5	1.5	-1.5
Delay discount hyperbolic model param	1.6	1.7	2.3	1.4	-0.3	1.2	-1.5	1.5	-1.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	-0.2	0.4	0.0	-0.1	-0.2	0.3
Change in fecal boli incidents, locomotor task	3.1	2.9	4.4	-2.1	-1.0	-1.7	1.7	-1.8	1.7
Time >=10cm from walls, locomotor time 1	2.7	2.7	3.4	1.6	1.4	1.8	-1.7	1.6	-1.7
Bouts of movement, locomotor time 1	1.0	1.2	2.0	-1.1	-0.2	-1.1	1.0	-1.3	1.4
Total resting periods, locomotor time 1	1.5	1.6	2.6	-1.4	-0.4	-1.3	1.1	-1.5	1.6
Rest time, locomotor task time 1	0.4	0.5	0.9	-0.8	-0.9	-0.6	0.3	-0.6	0.7
Distance moved, locomotor task time 1	0.4	0.4	1.1	0.6	1.0	0.6	-0.1	0.5	-0.7
Vertical activity count, locomotor time 1	1.1	1.2	1.6	1.3	1.2	1.1	-0.6	1.1	-1.2
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.7	0.2	0.2	-0.3	0.4	-0.2
Bouts of movement, locomotor time 2	0.7	0.8	1.4	-0.8	1.0	-0.5	1.2	-0.8	0.8
Total resting periods, locomotor time 2	0.4	0.5	1.9	-0.4	1.4	-0.0	0.7	-0.4	0.4
Rest time, locomotor task time 2	0.1	0.1	0.2	0.0	0.3	0.5	-0.3	0.2	-0.2
Distance moved, locomotor task time 2	0.1	0.2	0.5	0.0	0.3	-0.5	0.7	-0.3	0.3
Vertical activity count, locomotor time 2	0.3	0.3	1.0	0.8	1.0	0.2	0.2	0.2	-0.2
Weight adjusted by age	0.6	0.7	1.2	1.1	-1.1	0.2	-0.4	0.8	-0.8
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	2.1	1.4	0.2	1.1	-1.2	1.3	-1.4
Locomotion in novel chamber	0.1	0.2	0.6	-0.1	0.8	-0.1	0.3	-0.3	0.3
Locomotion in novel chamber post-restriction	2.2	2.6	3.7	1.6	-0.2	1.5	-1.9	1.9	-1.9
Progressive ratio	0.3	0.3	0.6	-0.6	-0.0	-0.6	0.5	-0.7	0.7
Food seeking constrained by brief footshock	0.3	0.4	0.6	-0.8	-0.8	-0.6	0.3	-0.6	0.6
Seeking ratio, punishment vs. effort	0.2	0.3	0.4	0.4	0.1	0.6	-0.6	0.6	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.5	0.3	0.7	0.5	-0.5	0.1	-0.1
Run reversals in cocaine runway, males	0.5	0.5	2.5	-0.0	-1.6	-0.1	-0.3	0.3	-0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.4	0.2	0.7	0.5	-0.1	0.2	-0.1
Latency to leave start box in cocaine runway, F	0.6	0.7	1.6	0.9	1.3	0.9	-0.3	0.6	-0.4
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.2	0.2	-0.3
Cd content in liver	1.0	1.1	1.7	-0.8	0.5	-1.0	1.3	-1.2	1.2
Co content in liver	0.0	0.1	0.1	-0.3	0.3	-0.0	0.1	-0.3	0.2
Cu content in liver	0.6	0.7	2.1	-0.9	-1.5	-0.8	0.5	-0.5	0.5
Fe content in liver	0.3	0.4	0.5	-0.7	0.6	-0.3	0.6	-0.7	0.7
K content in liver	3.6	3.6	4.4	2.0	1.1	2.0	-2.1	2.0	-2.0
Mg content in liver	3.2	3.3	4.4	1.8	2.1	2.0	-1.7	1.6	-1.6
Mn content in liver	0.0	0.0	0.1	0.3	-0.1	0.0	-0.1	0.2	-0.2
Na content in liver	0.0	0.0	0.0	-0.2	0.1	0.0	-0.0	-0.1	0.0
Rb content in liver	1.6	2.0	3.1	1.8	0.8	1.4	-1.4	1.5	-1.5
Se content in liver	0.8	1.0	1.6	0.7	0.3	1.2	-1.3	1.1	-1.1
Sr content in liver	1.9	1.7	3.2	-1.4	-1.8	-1.4	0.9	-1.1	1.1
Zn content in liver	0.0	0.0	0.1	-0.3	0.0	0.0	0.1	-0.1	0.1