Hub : Genes

Ccl21

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000034290 0.05 0.04 5.7e-04 0.02 0.02 0.03 0 4.3e-03 9.6e-03 1.1e-03 1.6e-01
2 IL gene expression ENSRNOG00000034290 0.31 0.16 3.7e-06 0.26 0.24 0.23 0.25 5.3e-07 1.6e-06 3.9e-06 8.2e-07
3 Liver gene expression ENSRNOG00000034290 0.09 0.05 7.2e-10 0.08 0.07 0.06 0.07 4.7e-09 1.2e-08 1.2e-07 1.6e-08
4 PL gene expression ENSRNOG00000034290 0.13 0.08 5.1e-10 0.14 0.13 0.12 0.14 1.2e-10 7.8e-10 2.0e-09 6.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail2.06.48.3-2.9-2.52.2-2.5
BMI without tail6.012.514.0-3.7-3.63.3-3.6
Body weight3.514.916.3-4.0-3.93.5-4.0
Epididymis fat weight0.81.82.3-1.2-1.51.2-1.5
Glucose1.21.81.9-1.4-1.41.4-1.2
Heart weight0.91.21.6-1.1-1.21.0-1.2
Left kidney weight0.61.72.3-1.0-1.51.5-1.0
Right kidney weight0.00.10.3-0.1-0.60.4-0.2
Tail length2.98.99.8-3.0-3.12.7-3.1
Length with tail1.13.95.0-1.8-2.11.8-2.2
Length without tail0.30.71.31.10.8-0.80.7
Liver weight, left0.71.11.5-1.0-1.11.2-0.7
Liver weight, right0.00.00.00.20.00.2-0.1
Parametrial fat weight0.20.40.4-0.6-0.60.6-0.6
Retroperitoneal fat weight0.10.40.80.40.6-0.90.5
Intraocular pressure2.73.94.4-1.7-2.12.0-2.0
Extensor digitorum longus weight5.421.623.6-4.6-4.64.5-4.9
Soleus weight0.10.20.30.4-0.30.3-0.5
Tibialis anterior weight9.031.033.9-5.3-5.65.5-5.8
Tibia length0.10.30.5-0.0-0.60.5-0.7
Number of licking bursts6.37.57.9-2.8-2.72.7-2.8
Food consumed during 24 hour testing period1.31.61.7-1.1-1.31.3-1.3
Times rat made contact with spout0.50.60.6-0.8-0.70.7-0.7
Mean time between licks in bursts0.30.40.50.70.7-0.70.5
Mean num. licks in bursts3.13.84.31.91.9-1.92.1
Std. dev. time between licks in bursts0.50.60.60.70.8-0.80.7
Water consumed over 24 hours1.31.51.6-1.1-1.21.2-1.3
Indifference point 0 sec0.50.71.1-0.1-1.10.9-1.0
Indifference point AUC7.99.39.6-3.1-3.13.0-3.0
Indifference point function ln k2.43.33.71.91.8-1.91.7
Indifference point function log k2.43.33.71.91.8-1.91.7
Delay discounting total patch changes 0 sec0.91.42.0-0.6-1.41.2-1.3
Delay discounting total patch changes 12 sec2.12.83.1-1.7-1.81.6-1.6
Delay discounting total patch changes 18 sec0.70.91.1-0.9-1.10.9-1.0
Delay discounting total patch changes 24 sec2.32.93.1-1.5-1.81.7-1.8
Delay discounting total patch changes 6 sec3.04.55.2-1.8-2.32.1-2.3
Delay discounting time to switch 0 sec2.64.04.91.82.0-1.92.2
Delay discounting water rate 0 sec1.62.63.2-1.4-1.71.6-1.8
Delay discounting water rate 12 sec0.00.10.20.0-0.10.1-0.5
Delay discounting water rate 18 sec0.20.30.4-0.6-0.40.5-0.6
Delay discounting water rate 24 sec0.10.10.2-0.10.4-0.40.3
Delay discounting water rate 6 sec1.21.82.3-1.2-1.21.3-1.5
Locomotor activity0.00.10.2-0.2-0.40.3-0.2
Locomotor testing distance0.10.10.30.1-0.50.3-0.2
Locomotor testing rearing1.72.73.5-1.3-1.91.6-1.7
Light reinforcement 12.13.94.7-1.2-2.22.1-2.2
Light reinforcement 21.01.31.9-0.2-1.41.4-1.2
Reaction time number correct0.10.10.2-0.1-0.50.3-0.4
Reaction time mean minus median0.20.31.1-1.10.20.00.1
Reaction time mean minus median AUC0.50.61.9-1.4-0.30.6-0.4
Reaction time num false alarms0.00.00.1-0.10.2-0.20.2
Reaction time num false alarms AUC0.20.30.4-0.6-0.50.5-0.4
Reaction time trials correct on left0.10.10.2-0.1-0.50.3-0.4
Reaction time trials on left0.00.10.10.0-0.30.2-0.3
Reaction time mean1.62.23.30.81.8-1.61.5
Reaction time mean AUC2.02.73.90.92.0-1.71.7
Median of all reaction times2.93.95.11.62.3-2.11.9
Reaction time omissions1.72.42.91.31.7-1.71.5
Reaction time false alarm rate0.10.10.20.00.3-0.30.5
Reaction time premature initiation rate2.93.94.81.62.1-2.22.0
Reaction time premature initiations1.82.53.31.41.6-1.81.6
Std. dev. reaction times0.40.60.9-0.30.9-0.80.8
Reaction time trials completed0.00.10.10.0-0.30.2-0.3
Reaction time trials AUC0.00.10.10.0-0.30.2-0.3
Social response proportion2.42.63.41.31.6-1.61.8
Social responses0.60.70.9-1.0-0.90.9-0.6
Social time0.00.00.00.1-0.0-0.10.2
Conditioned locomotion0.00.00.00.2-0.10.20.1
Cocaine response after cond. corrected1.21.42.51.61.1-1.00.9
Cocaine response after cond. not corrected0.80.91.91.40.8-0.80.7
Cocaine response before conditioning1.01.21.5-1.2-1.11.0-1.1
Saline control response1.41.92.3-1.0-1.41.4-1.5
Condit. Reinf. active minus inactive responses0.70.91.1-1.0-0.90.9-0.9
Condit. Reinf. active-inactive response ratio0.00.00.1-0.3-0.20.1-0.2
Condit. Reinf. active responses2.63.64.0-2.0-1.91.8-1.9
Condit. Reinf. inactive responses3.54.45.4-2.3-2.01.9-2.0
Condit. Reinf. lever presses1.92.74.1-2.0-1.51.3-1.6
Condit. Reinf. lever reinforcers received2.94.14.6-2.1-2.01.9-2.1
Pavlov. Cond. lever latency2.33.14.72.21.6-1.51.7
Pavlov. Cond. magazine entry latency0.30.30.40.40.6-0.60.5
Pavlov. Cond. change in total contacts0.50.61.6-1.2-0.50.4-0.7
Pavlov. Cond. index score0.10.10.4-0.6-0.10.1-0.3
Pavlov. Cond. latency score0.20.20.6-0.8-0.30.2-0.4
Pavlov. Cond. lever contacts1.11.52.3-1.5-1.11.0-1.2
Pavlov. Cond. magazine entry number0.00.10.20.4-0.10.10.1
Pavlov. Cond. intertrial magazine entries0.50.60.7-0.6-0.80.8-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.6-0.10.1-0.3
Pavlov. Cond. response bias0.40.61.1-1.1-0.60.5-0.8
Conditioned reinforcement - actives1.01.01.6-0.6-1.21.0-1.1
Conditioned reinforcement - inactives0.30.30.7-0.1-0.40.8-0.6
Conditioned locomotion0.81.01.6-0.8-1.10.8-1.3
Intermittent access intake day 1-15 change0.60.61.3-1.2-0.60.5-0.7
Intermittent access intake escalation1.01.01.9-1.4-0.80.7-0.9
Intermittent access intake escalation 21.31.32.3-1.5-1.01.0-1.0
Intermitt. access day 1 inactive lever presses0.70.81.0-0.9-0.81.0-0.8
Intermitt. access day 15 inactive lever presses0.20.20.3-0.3-0.40.6-0.5
Intermitt. access escalation Index1.21.11.2-1.0-1.11.1-1.0
Intermittent access day 1 total infusions0.30.31.01.00.2-0.50.3
Intermittent access day 15 total infusions0.60.60.8-0.7-0.90.7-0.9
Intermittent access terminal intake (last 3 days)1.51.72.0-1.0-1.41.3-1.4
Intermittent access total infusions1.21.31.7-0.8-1.31.1-1.3
Intermittent access day 1 locomotion1.31.32.21.50.9-1.11.0
Intermittent access day 15 total locomotion0.80.81.11.00.9-1.00.7
Intermittent access total locomotion0.60.70.80.80.8-0.90.7
Intermittent access standard deviation0.70.80.8-0.9-0.90.8-0.9
Cocaine induced anxiety0.60.71.11.10.8-0.60.8
Post-drug Anxiety0.70.80.9-0.8-0.91.0-0.9
Baseline Anxiety0.70.81.5-1.2-0.80.6-0.8
Lifetime Intake1.92.12.7-0.8-1.61.5-1.7
Incentive Sensitization - Responses0.60.60.9-0.2-0.81.0-0.8
Incentive Sensitization - Breakpoint0.30.40.6-0.1-0.60.8-0.6
Progressive ratio test 1 active lever presses0.90.91.3-0.2-1.11.2-1.0
Progressive ratio test 1 breakpoint1.21.21.7-0.4-1.31.3-1.2
Progressive ratio test 1 inactive lever presses1.51.62.5-0.4-1.31.6-1.4
Progressive ratio test 2 active lever presses0.60.70.90.1-1.01.0-0.9
Progressive ratio test 2 breakpoint0.30.30.40.3-0.60.6-0.6
Progressive ratio test 2 inactive lever presses1.11.31.9-0.7-1.41.1-1.3
Total sessions with >9 infusions0.60.71.00.1-0.90.9-1.0
Short access day 1 total inactive lever presses4.34.85.8-1.7-2.22.4-2.3
Short access day 10 total inactive lever presses0.40.40.5-0.7-0.50.7-0.7
Short access day 1 total infusions4.14.35.4-1.2-2.32.3-2.3
Short access day 10 total infusions1.21.32.0-0.5-1.31.1-1.4
Short access total infusions1.71.82.5-0.4-1.51.5-1.6
Short access day 1 locomotion0.10.10.20.5-0.0-0.3-0.1
Short access day 10 total locomotion1.01.11.21.01.0-1.11.0
Short access total locomotion0.10.10.30.1-0.40.2-0.5
Compulsive drug intake0.10.10.2-0.3-0.50.4-0.3
One hour access (0.3 mA shock)0.70.81.2-0.3-1.11.0-0.9
One hour access (shock baseline)0.60.70.9-0.3-1.00.9-1.0
Number of responses in last shaping day1.11.21.8-0.3-1.41.1-1.2
Context. condit. distance diff. score0.10.20.30.30.5-0.30.5
Locomotion velocity, session 10.90.91.3-0.2-1.21.1-1.1
Locomotion distance, session 10.50.60.9-0.4-0.90.9-0.7
Locomotion velocity, session 22.22.63.1-1.8-1.61.5-1.6
Locomotion distance, session 22.84.04.5-1.8-2.12.1-2.0
Locomotion velocity, session 30.10.10.20.0-0.40.4-0.4
Locomotion distance, session 32.52.73.1-1.5-1.81.7-1.6
Stereotopy head waving bouts, day 30.10.10.30.60.1-0.1-0.1
Stereotopy head waving duration, day 30.30.30.70.80.5-0.50.2
Locomotion velocity, session 70.10.10.10.20.4-0.40.2
Locomotion distance, session 70.30.40.4-0.6-0.60.6-0.6
Stereotopy head waving bouts, day 72.42.73.0-1.5-1.71.7-1.7
Stereotopy head waving duration, day 70.70.81.0-0.7-0.91.0-1.0
Locomotion velocity, session 80.10.20.3-0.1-0.40.6-0.4
Locomotion distance, session 80.30.50.7-0.5-0.80.9-0.6
Degree of sensitization distance1.11.11.21.01.1-1.10.9
Degree of sensitization stereotypy1.31.51.6-1.2-1.21.3-1.2
Condit. Reinf. active minus inactive responses0.50.60.8-0.9-0.80.7-0.7
Condit. Reinf. active-inactive response ratio0.70.80.90.80.9-1.00.9
Condit. Reinf. active responses3.03.64.6-2.1-1.91.8-1.8
Condit. Reinf. inactive responses3.33.95.2-2.3-1.91.9-1.9
Incentive salience index mean5.06.16.5-2.6-2.52.4-2.4
Condit. Reinf. lever presses12.216.316.9-4.0-4.14.1-4.0
Time in familiar zone, hab. session 10.80.70.90.31.0-1.00.9
Time in novel zone, hab. session 11.01.02.21.50.8-0.80.6
Total zone transitions, hab. session 10.00.00.0-0.1-0.10.10.1
Total locomotion distance, hab. session 10.20.30.8-0.9-0.50.4-0.2
Locomotion velocity, hab. session 11.31.93.0-1.7-1.41.3-1.1
Time in familiar zone, hab. session 20.80.91.10.61.0-1.11.0
Time in novel zone, hab. session 20.90.91.91.40.9-0.80.7
Total zone transitions, hab. session 20.70.91.0-0.8-1.01.0-0.9
Total locomotion distance, hab. session 20.81.11.3-1.1-1.11.1-0.9
Locomotion velocity, hab. session 21.11.51.7-1.3-1.21.2-1.0
Novel to familiar place preference ratio2.93.14.72.21.6-1.61.5
Novelty place preference4.34.46.22.52.0-2.01.9
Time in novel zone, NPP test5.25.47.52.72.2-2.22.1
Total zone transitions, NPP test0.91.31.7-0.9-1.31.3-1.1
Total locomotion distance, NPP test2.23.03.6-1.6-1.91.8-1.6
Locomotion velocity, NPP test2.73.94.5-1.9-2.12.0-1.8
Pavlov. Cond. lever latency9.011.511.73.43.4-3.33.4
Pavlov. Cond. magazine entry latency0.50.60.8-0.9-0.80.6-0.8
Pavlov. Cond. change in total contacts3.43.63.9-1.9-2.01.9-1.9
Pavlov. Cond. index score3.74.85.3-2.3-2.22.1-2.2
Pavlov. Cond. latency score3.54.54.8-2.2-2.12.0-2.1
Pavlov. Cond. lever contacts6.27.47.6-2.8-2.72.6-2.7
Pavlov. Cond. magazine entry number0.91.21.51.21.1-0.91.0
Pavlov. Cond. intertrial magazine entries0.20.20.3-0.5-0.40.5-0.4
Pavlov. Cond. lever-magazine prob. diff.3.24.04.8-2.2-2.01.8-2.0
Pavlov. Cond. response bias3.74.55.0-2.2-2.12.0-2.1
Bone: apparent density1.11.92.5-1.6-1.31.2-1.4
Bone surface0.81.42.0-1.1-1.21.1-1.4
Bone volume0.81.31.6-1.2-1.11.0-1.3
Bone: connectivity density0.40.71.1-1.0-0.70.6-0.9
Bone: cortical apparent density0.10.10.2-0.10.4-0.40.4
Bone: cortical area2.23.44.3-2.1-1.71.7-1.8
Bone: cortical porosity0.60.60.70.80.8-0.70.8
Bone: cortical porosity0.00.00.00.10.1-0.00.1
Bone: cortical thickness0.60.91.8-1.3-0.80.7-0.8
Bone: cortical thickness0.20.20.40.20.5-0.50.6
Bone: cortical tissue density0.10.20.20.00.4-0.40.5
Bone: elastic displacement6.16.98.02.42.7-2.82.6
Bone: elastic work2.63.44.41.32.0-2.11.9
Bone: endosteal estimation1.43.03.9-1.4-1.71.8-2.0
Bone: endosteal perimeter1.53.04.2-1.4-1.71.7-2.0
Bone: final force1.52.53.2-1.6-1.61.4-1.8
Bone: final moment1.11.82.3-1.4-1.31.1-1.5
Bone: marrow area1.43.14.0-1.5-1.71.8-2.0
Bone: maximum diameter2.64.85.4-2.2-2.12.1-2.3
Bone: maximum force3.45.86.4-2.5-2.42.2-2.5
Bone: maximum moment2.54.34.9-2.2-2.01.9-2.2
Bone: minimum diameter0.00.10.10.20.4-0.40.1
Bone: periosteal estimation1.93.94.7-1.9-1.91.9-2.2
Bone: periosteal perimeter0.71.21.8-0.8-1.01.1-1.3
Bone: post-yield work2.02.83.1-1.4-1.71.7-1.8
Bone: stiffness4.67.28.1-2.8-2.72.5-2.7
Bone: tissue strength0.30.30.4-0.5-0.60.4-0.5
Bone: trabecular number1.11.72.5-1.6-1.21.0-1.3
Bone: trabecular spacing0.00.00.1-0.10.1-0.00.3
Bone: trabecular thickness0.20.20.30.40.5-0.50.3
Bone: trabecular tissue density3.44.85.5-2.2-2.22.3-2.0
Breakpoint value in progressive ratio session0.30.30.80.90.2-0.60.3
Distance traveled before self-admin7.68.19.2-2.6-2.73.0-3.0
Distance traveled after self-admin1.82.02.2-1.4-1.21.5-1.5
Delta time in closed arm before/after self-admin1.51.52.9-1.7-0.91.0-1.1
Delta time in open arm before/after self-admin0.20.20.50.70.2-0.20.3
Diff in mean of infusions in LGA sessions0.10.20.40.20.3-0.60.3
Extinction: sum of active levers before priming1.71.72.11.41.3-1.31.2
Active lever presses in extinction session 61.11.11.31.00.9-1.11.0
Delta distance traveled before/after self-admin0.20.30.30.60.5-0.40.5
Delta ambulatory time before/after self-admin1.11.11.21.11.1-1.01.1
Time in closed arm before self-admin3.23.74.32.01.8-1.82.1
Time in closed arm after self-admin0.40.40.60.30.7-0.60.8
Time in open arm before self-admin3.33.54.5-1.6-1.91.8-2.1
Time in open arm after self-admin1.82.02.5-1.0-1.51.5-1.6
Sum of active levers in priming session hrs 5-63.93.84.92.21.8-1.91.8
Time to tail flick, vehicle, before self-admin2.92.93.41.51.7-1.91.8
Time to tail flick, vehicle, after self-admin0.00.00.0-0.1-0.20.2-0.2
Time to tail flick, test, before self-admin0.30.30.5-0.5-0.40.7-0.4
Time to tail flick, test, after self-admin0.20.20.7-0.8-0.50.1-0.3
Delta time to tail flick, vehicle, before/after SA0.90.91.1-0.8-0.91.0-1.0
Delta time to tail flick, test, before/after SA0.20.20.40.20.4-0.60.5
Ambulatory time before self-admin5.75.96.9-2.0-2.42.6-2.6
Ambulatory time after self-admin0.70.71.0-0.7-0.70.9-1.0
Total heroin consumption0.20.20.50.70.3-0.30.3
Area under the delay curve0.40.40.60.80.5-0.70.5
Delay disc. indifference point, 0s delay1.11.21.71.30.9-1.01.0
Delay disc. indifference point, 16s delay0.60.61.41.20.6-0.50.6
Delay disc. indifference point, 2s delay0.00.00.1-0.30.00.1-0.1
Delay disc. indifference point, 24s delay0.20.20.30.30.5-0.50.4
Delay disc. indifference point, 4s delay0.10.10.30.30.3-0.60.2
Delay disc. indifference point, 8s delay0.00.00.0-0.1-0.1-0.2-0.1
Delay discount exponential model param0.30.30.4-0.7-0.50.6-0.4
Delay discount hyperbolic model param0.20.30.4-0.6-0.40.6-0.4
Fecal boli incidents, locomotor time 11.71.82.11.21.4-1.51.4
Change in fecal boli incidents, locomotor task1.61.62.1-1.0-1.21.3-1.4
Time >=10cm from walls, locomotor time 10.10.10.20.0-0.40.3-0.3
Bouts of movement, locomotor time 11.82.02.21.41.5-1.41.4
Total resting periods, locomotor time 12.83.13.51.61.9-1.81.8
Rest time, locomotor task time 12.62.93.91.02.0-1.81.8
Distance moved, locomotor task time 13.23.54.3-1.4-2.12.0-1.9
Vertical activity count, locomotor time 12.22.33.3-0.8-1.81.8-1.4
Time >=10cm from walls, locomotor time 20.10.10.2-0.3-0.40.3-0.3
Bouts of movement, locomotor time 20.70.70.9-0.8-0.80.8-0.9
Total resting periods, locomotor time 20.20.20.3-0.5-0.40.4-0.6
Rest time, locomotor task time 21.21.51.91.01.4-1.31.1
Distance moved, locomotor task time 20.50.60.9-1.0-0.80.7-0.5
Vertical activity count, locomotor time 20.60.70.9-0.8-0.90.9-0.7
Weight adjusted by age0.00.10.10.0-0.20.2-0.3
Seeking ratio, delayed vs. immediate footshock3.84.35.0-2.2-2.12.0-2.0
Locomotion in novel chamber0.10.10.20.20.4-0.40.4
Locomotion in novel chamber post-restriction1.21.42.5-1.6-1.10.9-1.1
Progressive ratio0.00.10.10.20.2-0.10.3
Food seeking constrained by brief footshock10.612.916.2-3.0-3.74.0-3.6
Seeking ratio, punishment vs. effort3.13.84.6-1.7-2.02.1-2.0
Run reversals in cocaine runway, females0.10.10.20.10.3-0.30.4
Run reversals in cocaine runway, males0.00.00.10.20.2-0.10.2
Latency to leave start box in cocaine runway0.80.91.3-1.2-0.80.8-1.0
Latency to leave start box in cocaine runway, F0.00.00.10.00.2-0.20.0
Latency to leave start box in cocaine runway, M2.32.32.5-1.3-1.51.6-1.6
Cd content in liver1.11.21.3-1.1-1.11.0-1.2
Co content in liver1.01.21.71.31.1-1.00.9
Cu content in liver1.01.21.60.91.2-1.11.3
Fe content in liver0.40.50.8-0.0-0.90.7-0.8
K content in liver0.30.30.40.60.5-0.60.3
Mg content in liver1.21.21.51.11.2-1.20.9
Mn content in liver0.00.10.2-0.40.1-0.1-0.2
Na content in liver1.31.31.71.11.1-1.11.3
Rb content in liver4.45.56.22.52.3-2.32.3
Se content in liver1.82.12.9-1.7-1.31.4-1.4
Sr content in liver0.30.30.4-0.7-0.50.4-0.6
Zn content in liver0.10.10.2-0.30.4-0.20.2