Aox2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000033923	0.05	0.03	2.9e-05	0.01	0.03	0.02	0.02	3.2e-02	8.6e-04	1.7e-03	5.1e-03
2	Brain	gene expression	ENSRNOG00000033923	0.07	0.04	1.1e-04	0.01	0.04	0.03	0.03	2.1e-02	1.3e-04	6.4e-04	6.0e-04
3	Liver	gene expression	ENSRNOG00000033923	0.85	0.06	0.0e+00	0.64	0.66	0.66	0.66	4.2e-93	1.4e-97	5.9e-99	3.7e-99
4	Liver	intron excision ratio	chr9:59896869:59897269	0.11	0.07	5.4e-11	0.09	0.08	0.07	0.08	2.4e-10	1.3e-09	1.7e-08	1.3e-09
5	Liver	intron excision ratio	chr9:59896869:59899773	0.11	0.06	9.9e-11	0.09	0.08	0.07	0.08	4.9e-10	2.2e-09	2.0e-08	1.5e-09
6	Liver	mRNA stability	ENSRNOG00000033923	0.1	0.05	2.1e-10	0.09	0.06	0.08	0.08	5.9e-10	1.0e-07	4.8e-09	5.8e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	2.5	8.0	14.5	3.8	3.0	-2.2	2.5	-2.5	-2.5
BMI without tail	0.8	1.7	7.5	1.5	2.7	-0.4	0.0	-0.0	-0.2
Body weight	0.1	0.3	0.5	-0.6	0.2	0.4	-0.7	0.7	0.6
Epididymis fat weight	2.5	5.9	8.3	-2.3	1.0	2.1	-2.9	2.9	2.9
Glucose	0.5	0.8	1.9	1.2	1.4	-0.7	0.6	-0.6	-0.5
Heart weight	0.5	0.8	2.0	0.4	-0.7	-1.4	0.8	-0.8	-0.9
Left kidney weight	0.1	0.3	1.9	-0.0	-0.1	-1.4	0.1	-0.1	-0.2
Right kidney weight	0.0	0.1	0.6	-0.2	-0.2	-0.8	0.0	-0.0	-0.0
Tail length	4.6	13.9	23.4	-4.8	-2.5	2.9	-3.9	3.9	3.8
Length with tail	4.3	15.8	28.4	-5.3	-3.2	3.2	-4.0	4.0	3.8
Length without tail	0.9	1.9	5.2	-2.0	-2.3	0.8	-0.8	0.8	0.8
Liver weight, left	1.4	2.3	3.2	-1.3	0.7	1.4	-1.8	1.8	1.8
Liver weight, right	0.7	1.1	4.5	-1.3	-2.1	-0.3	-0.3	0.3	0.4
Parametrial fat weight	0.3	0.5	0.8	-0.4	0.8	0.8	-0.9	0.9	0.6
Retroperitoneal fat weight	0.3	0.8	1.7	-0.1	1.3	1.3	-0.7	0.7	0.8
Intraocular pressure	2.8	3.9	6.3	2.5	1.0	-1.9	2.1	-2.1	-1.9
Extensor digitorum longus weight	0.6	2.6	8.9	1.9	3.0	-1.4	0.6	-0.6	-0.6
Soleus weight	0.1	0.3	0.8	0.2	0.8	-0.9	-0.2	0.2	-0.0
Tibialis anterior weight	0.0	0.0	0.2	0.1	0.4	-0.2	-0.1	0.1	0.1
Tibia length	2.5	7.1	13.5	-3.7	-2.6	1.2	-2.6	2.6	2.6
Number of licking bursts	0.3	0.3	1.2	-0.1	-1.1	-0.6	0.4	-0.4	-0.4
Food consumed during 24 hour testing period	1.1	1.3	2.4	1.5	0.9	-0.9	1.2	-1.2	-1.1
Times rat made contact with spout	0.6	0.7	1.7	1.2	1.3	0.1	0.6	-0.6	-0.5
Mean time between licks in bursts	1.5	2.1	5.4	-0.3	2.3	1.2	-1.3	1.3	1.4
Mean num. licks in bursts	0.7	0.9	4.2	0.9	2.1	0.5	0.0	-0.0	0.0
Std. dev. time between licks in bursts	0.5	0.6	1.1	1.0	1.0	-0.7	0.6	-0.6	-0.5
Water consumed over 24 hours	4.7	5.5	7.7	2.8	0.8	-2.3	2.5	-2.5	-2.6
Indifference point 0 sec	0.3	0.6	1.0	0.7	-0.1	-1.0	0.8	-0.8	-0.7
Indifference point AUC	0.3	0.4	1.6	-0.7	-1.3	-0.5	-0.0	0.0	0.1
Indifference point function ln k	0.1	0.2	0.6	0.4	0.8	0.4	0.2	-0.2	-0.0
Indifference point function log k	0.1	0.2	0.6	0.4	0.8	0.4	0.2	-0.2	-0.0
Delay discounting total patch changes 0 sec	0.8	1.4	2.0	1.0	-0.3	-1.4	1.4	-1.4	-1.2
Delay discounting total patch changes 12 sec	0.2	0.3	0.8	0.1	-0.7	-0.9	0.5	-0.5	-0.4
Delay discounting total patch changes 18 sec	1.5	1.9	3.2	1.4	-0.0	-1.8	1.6	-1.6	-1.3
Delay discounting total patch changes 24 sec	0.4	0.4	1.6	-0.2	-1.3	-0.7	0.4	-0.4	-0.4
Delay discounting total patch changes 6 sec	0.9	1.3	3.0	0.9	-0.4	-1.7	1.2	-1.2	-1.1
Delay discounting time to switch 0 sec	0.3	0.4	0.8	0.9	0.6	-0.5	0.6	-0.6	-0.7
Delay discounting water rate 0 sec	0.3	0.5	0.7	-0.8	-0.3	0.6	-0.8	0.8	0.8
Delay discounting water rate 12 sec	0.2	0.4	0.5	0.7	0.2	-0.4	0.7	-0.7	-0.6
Delay discounting water rate 18 sec	0.4	0.6	1.6	0.1	-1.3	-0.9	0.6	-0.6	-0.7
Delay discounting water rate 24 sec	0.0	0.0	0.1	-0.0	0.3	0.3	-0.2	0.2	-0.0
Delay discounting water rate 6 sec	0.0	0.0	0.2	0.3	0.4	0.1	0.1	-0.1	-0.0
Locomotor activity	0.2	0.3	1.0	0.5	1.0	-0.7	0.0	-0.0	0.1
Locomotor testing distance	1.2	1.9	3.5	1.7	1.0	-1.9	1.3	-1.3	-1.0
Locomotor testing rearing	0.0	0.0	0.1	0.1	0.4	0.1	-0.2	0.2	0.2
Light reinforcement 1	2.0	3.7	7.9	2.6	2.8	-1.2	1.4	-1.4	-1.4
Light reinforcement 2	0.1	0.1	0.4	-0.1	0.6	-0.0	-0.3	0.3	0.4
Reaction time number correct	0.8	1.2	1.7	1.2	-0.0	-1.3	1.1	-1.1	-1.2
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.2	-0.0	-0.0	0.0	-0.0
Reaction time mean minus median AUC	0.5	0.6	0.8	0.4	-0.8	-0.7	0.9	-0.9	-0.9
Reaction time num false alarms	0.7	1.0	4.8	1.0	2.2	-0.1	-0.3	0.3	0.1
Reaction time num false alarms AUC	0.8	1.1	5.3	1.1	2.3	-0.2	-0.3	0.3	0.2
Reaction time trials correct on left	0.8	1.2	1.7	1.2	-0.0	-1.3	1.1	-1.1	-1.2
Reaction time trials on left	0.8	1.1	1.5	1.2	-0.0	-1.2	1.1	-1.1	-1.2
Reaction time mean	2.8	3.9	5.5	-2.2	-0.6	2.3	-2.1	2.1	1.9
Reaction time mean AUC	2.3	3.1	4.4	-2.0	-0.5	2.1	-1.9	1.9	1.7
Median of all reaction times	4.5	6.1	8.7	-2.8	-0.8	3.0	-2.6	2.6	2.4
Reaction time omissions	0.6	0.8	1.5	-0.8	0.1	1.2	-1.0	1.0	0.7
Reaction time false alarm rate	0.8	1.1	3.8	0.2	1.9	0.6	-0.9	0.9	0.8
Reaction time premature initiation rate	2.2	2.9	6.3	0.8	-1.4	-2.5	1.7	-1.7	-1.6
Reaction time premature initiations	3.2	4.5	9.0	1.5	-1.1	-3.0	2.2	-2.2	-2.2
Std. dev. reaction times	0.5	0.7	1.3	-1.1	-0.7	0.7	-0.8	0.8	0.8
Reaction time trials completed	0.8	1.1	1.5	1.2	-0.0	-1.2	1.1	-1.1	-1.2
Reaction time trials AUC	0.6	0.8	1.1	1.0	-0.0	-1.1	0.9	-0.9	-1.0
Social response proportion	0.7	0.8	1.2	-1.1	-0.5	0.1	-1.0	1.0	1.0
Social responses	1.6	2.1	3.2	-1.7	-0.5	0.5	-1.8	1.8	1.7
Social time	0.3	0.4	0.7	-0.9	-0.6	0.1	-0.6	0.6	0.6
Conditioned locomotion	1.8	2.2	3.6	-1.4	0.4	1.1	-1.7	1.7	1.9
Cocaine response after cond. corrected	1.8	2.0	3.4	-1.5	-0.3	1.8	-1.5	1.5	1.4
Cocaine response after cond. not corrected	1.0	1.1	2.3	-1.4	-1.5	0.7	-0.8	0.8	0.7
Cocaine response before conditioning	2.9	3.5	6.9	0.7	-2.1	-2.6	1.8	-1.8	-1.6
Saline control response	0.3	0.4	0.5	0.5	-0.4	-0.7	0.7	-0.7	-0.7
Condit. Reinf. active minus inactive responses	1.1	1.4	5.6	-1.5	-2.4	0.1	-0.3	0.3	0.5
Condit. Reinf. active-inactive response ratio	1.4	1.5	7.1	-0.6	-2.7	-0.5	0.7	-0.7	-0.6
Condit. Reinf. active responses	1.1	1.5	4.8	-1.6	-2.2	0.2	-0.7	0.7	0.8
Condit. Reinf. inactive responses	0.4	0.5	0.8	-0.8	-0.1	0.3	-0.9	0.9	0.8
Condit. Reinf. lever presses	1.3	1.8	2.9	0.6	-1.7	-1.4	1.4	-1.4	-1.4
Condit. Reinf. lever reinforcers received	1.0	1.4	5.4	-1.5	-2.3	0.1	-0.5	0.5	0.6
Pavlov. Cond. lever latency	1.2	1.7	3.4	-0.5	1.8	1.1	-1.3	1.3	1.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.3	-0.8	-0.2	0.7	-0.7	-0.7
Pavlov. Cond. change in total contacts	1.0	1.3	6.0	-1.3	-2.4	0.3	-0.3	0.3	0.2
Pavlov. Cond. index score	0.6	0.8	3.5	-0.2	-1.9	-0.3	0.6	-0.6	-0.6
Pavlov. Cond. latency score	0.6	0.8	3.4	-0.2	-1.8	-0.4	0.6	-0.6	-0.6
Pavlov. Cond. lever contacts	1.1	1.5	4.3	0.1	-2.1	-1.0	1.0	-1.0	-1.1
Pavlov. Cond. magazine entry number	0.2	0.3	1.4	0.2	1.2	0.1	-0.3	0.3	0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	0.6	0.5	-0.9	0.4	-0.4	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	3.6	-0.4	-1.9	-0.2	0.4	-0.4	-0.4
Pavlov. Cond. response bias	0.6	0.9	3.1	-0.0	-1.8	-0.6	0.8	-0.8	-0.8
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.2	0.2	0.2	-0.5	0.5	0.1
Conditioned reinforcement - inactives	1.2	1.4	2.2	-1.5	-0.6	1.0	-1.3	1.3	1.2
Conditioned locomotion	0.2	0.2	0.7	0.6	0.8	-0.3	0.0	-0.0	-0.4
Intermittent access intake day 1-15 change	3.6	3.6	5.0	1.7	-0.5	-2.1	2.2	-2.2	-2.1
Intermittent access intake escalation	3.7	3.7	5.1	1.5	-0.9	-2.1	2.2	-2.2	-2.1
Intermittent access intake escalation 2	2.1	2.1	3.2	0.8	-1.0	-1.4	1.8	-1.8	-1.5
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.6	0.7	0.5	-0.3	0.4	-0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.5	0.0	-0.6	-0.7	0.4	-0.4	-0.3
Intermitt. access escalation Index	1.9	1.7	2.3	-0.6	1.4	1.0	-1.5	1.5	1.5
Intermittent access day 1 total infusions	0.3	0.3	1.3	-0.3	0.2	1.1	-0.6	0.6	0.2
Intermittent access day 15 total infusions	0.9	1.0	2.1	0.8	-0.5	-0.9	1.1	-1.1	-1.5
Intermittent access terminal intake (last 3 days)	1.6	1.7	3.0	1.1	-0.7	-1.2	1.5	-1.5	-1.7
Intermittent access total infusions	0.2	0.2	0.6	0.4	-0.3	-0.1	0.4	-0.4	-0.8
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.1	-0.1	0.3	0.0	-0.0	-0.3
Intermittent access day 15 total locomotion	0.4	0.4	0.6	0.3	-0.7	-0.7	0.7	-0.7	-0.7
Intermittent access total locomotion	0.0	0.0	0.1	0.2	0.1	0.3	0.1	-0.1	-0.4
Intermittent access standard deviation	1.6	1.7	2.7	1.2	-0.7	-0.8	1.6	-1.6	-1.6
Cocaine induced anxiety	0.2	0.2	0.7	0.2	0.8	-0.5	-0.1	0.1	0.3
Post-drug Anxiety	0.1	0.1	0.4	0.4	0.6	-0.3	0.3	-0.3	-0.0
Baseline Anxiety	0.4	0.4	1.2	-0.7	-0.8	1.1	-0.3	0.3	0.3
Lifetime Intake	0.1	0.2	0.5	0.5	0.1	0.1	0.3	-0.3	-0.7
Incentive Sensitization - Responses	0.8	0.8	1.2	-1.0	0.0	0.9	-1.1	1.1	0.8
Incentive Sensitization - Breakpoint	0.9	0.9	1.3	-1.0	0.2	1.0	-1.1	1.1	0.9
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	0.5	-0.1	-0.6	0.5	-0.5	-0.6
Progressive ratio test 1 breakpoint	0.6	0.6	0.9	0.7	-0.4	-0.9	0.9	-0.9	-0.9
Progressive ratio test 1 inactive lever presses	1.3	1.4	3.3	1.8	1.8	-0.6	0.7	-0.7	-0.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.2	0.1	-0.2	-0.2	0.0	-0.0	-0.4
Progressive ratio test 2 breakpoint	0.3	0.3	0.7	0.5	-0.1	-0.6	0.5	-0.5	-0.8
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	0.3	0.4	0.2	-0.1	0.1	-0.1
Total sessions with >9 infusions	0.6	0.7	1.5	1.2	0.7	-0.6	0.7	-0.7	-0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.0	0.3	-0.0	-0.2	0.2	0.2
Short access day 10 total inactive lever presses	0.1	0.2	0.3	-0.0	0.4	0.5	-0.3	0.3	0.6
Short access day 1 total infusions	0.7	0.7	1.3	1.1	0.2	-0.6	0.9	-0.9	-1.1
Short access day 10 total infusions	0.2	0.2	0.3	0.4	-0.1	-0.2	0.5	-0.5	-0.6
Short access total infusions	0.3	0.4	0.8	0.9	0.6	0.1	0.5	-0.5	-0.8
Short access day 1 locomotion	0.2	0.2	0.6	0.3	-0.3	-0.8	0.2	-0.2	-0.3
Short access day 10 total locomotion	0.3	0.4	0.5	0.3	-0.7	-0.2	0.7	-0.7	-0.7
Short access total locomotion	0.1	0.1	0.3	0.5	0.3	-0.0	0.3	-0.3	-0.4
Compulsive drug intake	0.2	0.2	0.9	-0.1	-1.0	-0.3	0.3	-0.3	-0.4
One hour access (0.3 mA shock)	0.7	0.9	1.7	0.2	-1.3	-0.4	1.0	-1.0	-1.2
One hour access (shock baseline)	0.0	0.0	0.1	-0.0	-0.2	0.1	0.2	-0.2	-0.3
Number of responses in last shaping day	0.6	0.6	1.8	0.4	-0.5	-1.4	0.6	-0.6	-0.7
Context. condit. distance diff. score	0.4	0.4	1.1	0.7	0.3	1.1	0.5	-0.5	-0.5
Locomotion velocity, session 1	0.5	0.5	1.7	0.7	1.3	0.9	0.1	-0.1	-0.0
Locomotion distance, session 1	0.8	1.0	1.9	1.4	0.9	-0.2	1.1	-1.1	-1.0
Locomotion velocity, session 2	0.3	0.3	1.3	0.4	1.1	0.6	-0.1	0.1	0.1
Locomotion distance, session 2	0.8	1.2	5.5	0.6	2.3	0.3	-0.5	0.5	0.6
Locomotion velocity, session 3	0.4	0.5	1.4	0.5	1.2	1.1	0.0	-0.0	-0.1
Locomotion distance, session 3	0.3	0.4	0.9	-0.5	0.1	0.9	-0.6	0.6	0.6
Stereotopy head waving bouts, day 3	0.8	0.9	1.2	1.0	0.1	-1.0	1.1	-1.1	-1.1
Stereotopy head waving duration, day 3	1.9	2.3	3.4	1.8	0.8	-1.5	1.6	-1.6	-1.6
Locomotion velocity, session 7	0.8	0.8	1.6	1.3	1.0	-0.1	0.9	-0.9	-0.9
Locomotion distance, session 7	0.5	0.6	1.5	0.1	1.2	0.9	-0.6	0.6	0.7
Stereotopy head waving bouts, day 7	0.3	0.3	1.2	-0.7	-1.1	0.4	-0.1	0.1	0.1
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.2	-0.1	-0.0	0.4	-0.4	-0.5
Locomotion velocity, session 8	0.2	0.2	0.8	0.3	0.5	0.9	0.1	-0.1	-0.2
Locomotion distance, session 8	0.3	0.4	1.3	0.5	0.9	1.1	-0.0	0.0	0.0
Degree of sensitization distance	0.3	0.3	0.6	0.7	0.5	-0.5	0.5	-0.5	-0.5
Degree of sensitization stereotypy	0.9	0.9	1.5	-1.1	-0.4	1.2	-0.9	0.9	0.9
Condit. Reinf. active minus inactive responses	0.9	1.0	3.9	-0.4	-2.0	-1.0	0.6	-0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.2	-0.0	-1.1	-0.9	0.6	-0.6	-0.5
Condit. Reinf. active responses	0.8	0.9	3.9	-1.2	-2.0	-0.3	-0.2	0.2	0.3
Condit. Reinf. inactive responses	0.6	0.7	1.1	-1.0	-0.4	0.6	-0.9	0.9	0.9
Incentive salience index mean	1.3	1.5	6.8	-0.9	-2.6	-1.1	0.4	-0.4	-0.4
Condit. Reinf. lever presses	0.6	0.9	4.0	-1.1	-2.0	-0.3	-0.0	0.0	0.1
Time in familiar zone, hab. session 1	1.3	1.2	2.0	0.9	-0.5	-0.6	1.4	-1.4	-1.4
Time in novel zone, hab. session 1	1.1	1.0	1.5	-0.9	0.3	1.0	-1.2	1.2	1.2
Total zone transitions, hab. session 1	0.2	0.2	0.5	-0.5	-0.5	0.7	-0.2	0.2	0.4
Total locomotion distance, hab. session 1	0.5	0.7	3.6	-0.7	-1.9	-0.3	0.2	-0.2	-0.1
Locomotion velocity, hab. session 1	0.4	0.6	2.7	-0.8	-1.6	-0.3	-0.0	0.0	0.1
Time in familiar zone, hab. session 2	1.6	1.6	2.2	0.9	-1.0	-1.2	1.5	-1.5	-1.4
Time in novel zone, hab. session 2	0.7	0.7	1.9	-0.0	1.4	0.7	-0.8	0.8	0.8
Total zone transitions, hab. session 2	0.3	0.4	1.5	0.9	1.2	0.2	0.4	-0.4	-0.1
Total locomotion distance, hab. session 2	0.3	0.3	1.0	0.8	1.0	-0.3	0.3	-0.3	-0.2
Locomotion velocity, hab. session 2	0.2	0.3	1.0	0.7	1.0	-0.3	0.2	-0.2	-0.1
Novel to familiar place preference ratio	0.1	0.1	0.6	0.4	0.8	0.2	-0.2	0.2	0.2
Novelty place preference	0.1	0.1	0.4	0.4	0.7	-0.0	-0.1	0.1	0.0
Time in novel zone, NPP test	0.1	0.1	0.4	0.6	0.6	-0.2	0.2	-0.2	-0.2
Total zone transitions, NPP test	0.0	0.0	0.1	0.2	-0.2	0.2	0.2	-0.2	-0.1
Total locomotion distance, NPP test	1.1	1.6	2.3	1.0	-0.7	-1.5	1.4	-1.4	-1.3
Locomotion velocity, NPP test	1.0	1.5	2.2	1.0	-0.6	-1.5	1.4	-1.4	-1.2
Pavlov. Cond. lever latency	0.5	0.6	2.9	0.8	1.7	0.1	0.1	-0.1	0.0
Pavlov. Cond. magazine entry latency	1.1	1.5	5.7	-0.5	-2.4	-1.3	0.6	-0.6	-0.6
Pavlov. Cond. change in total contacts	1.1	1.1	3.4	-0.1	-1.8	-1.2	0.8	-0.8	-0.8
Pavlov. Cond. index score	1.1	1.4	6.4	-0.7	-2.5	-0.7	0.5	-0.5	-0.5
Pavlov. Cond. latency score	1.1	1.4	6.6	-0.8	-2.6	-0.6	0.4	-0.4	-0.5
Pavlov. Cond. lever contacts	0.7	0.8	3.0	-0.2	-1.7	-0.7	0.6	-0.6	-0.7
Pavlov. Cond. magazine entry number	0.7	0.9	3.7	0.6	1.9	0.9	-0.3	0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-0.5	0.2	0.9	-0.6	0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	6.1	-0.5	-2.5	-0.9	0.7	-0.7	-0.8
Pavlov. Cond. response bias	0.9	1.1	5.3	-0.8	-2.3	-0.8	0.3	-0.3	-0.3
Bone: apparent density	0.3	0.6	2.0	-0.5	-1.4	-1.0	0.2	-0.2	-0.2
Bone surface	1.3	2.4	5.0	-2.2	-1.8	-0.0	-1.4	1.4	1.4
Bone volume	0.7	1.2	2.8	-1.6	-1.7	-0.5	-0.8	0.8	0.8
Bone: connectivity density	0.3	0.4	1.7	-0.2	-0.6	-1.3	0.3	-0.3	-0.3
Bone: cortical apparent density	1.4	1.8	3.3	1.8	1.1	-1.0	1.4	-1.4	-1.3
Bone: cortical area	1.1	1.6	3.0	-1.7	-1.0	0.1	-1.3	1.3	1.4
Bone: cortical porosity	2.5	2.6	5.0	-2.2	-2.0	0.8	-1.5	1.5	1.3
Bone: cortical porosity	2.7	2.9	5.6	-2.4	-2.3	0.6	-1.5	1.5	1.4
Bone: cortical thickness	0.0	0.1	0.3	-0.1	0.1	-0.5	-0.2	0.2	0.3
Bone: cortical thickness	1.4	1.7	2.6	1.2	-0.5	-1.6	1.4	-1.4	-1.3
Bone: cortical tissue density	1.5	1.9	3.6	1.9	1.3	-0.9	1.4	-1.4	-1.3
Bone: elastic displacement	2.0	2.2	3.4	1.4	-0.5	-1.2	1.8	-1.8	-1.8
Bone: elastic work	0.2	0.3	0.5	0.1	-0.7	-0.7	0.4	-0.4	-0.5
Bone: endosteal estimation	1.2	2.5	5.6	-2.3	-2.4	-0.0	-1.2	1.2	1.2
Bone: endosteal perimeter	1.2	2.5	5.0	-2.2	-1.9	0.4	-1.4	1.4	1.5
Bone: final force	1.0	1.7	3.0	-1.7	-1.2	-0.3	-1.4	1.4	1.3
Bone: final moment	0.5	0.8	1.3	-1.1	-1.1	-0.9	-0.7	0.7	0.6
Bone: marrow area	1.2	2.5	6.0	-2.2	-2.5	-0.1	-1.2	1.2	1.2
Bone: maximum diameter	2.1	3.8	6.9	-2.6	-1.9	1.0	-1.9	1.9	1.9
Bone: maximum force	0.6	1.0	1.6	-1.3	-1.2	-1.0	-0.8	0.8	0.8
Bone: maximum moment	0.4	0.7	2.6	-0.5	-1.1	-1.6	-0.1	0.1	0.0
Bone: minimum diameter	0.9	1.7	3.2	-1.8	-1.5	-0.6	-1.2	1.2	1.2
Bone: periosteal estimation	1.6	3.3	6.6	-2.6	-2.3	0.0	-1.6	1.6	1.6
Bone: periosteal perimeter	1.0	1.6	3.2	-1.8	-1.7	0.1	-1.1	1.1	1.1
Bone: post-yield work	0.9	1.2	3.3	0.9	-0.1	-1.8	1.0	-1.0	-1.0
Bone: stiffness	2.0	3.1	5.7	-2.4	-1.3	0.5	-1.9	1.9	2.0
Bone: tissue strength	0.1	0.1	0.3	-0.1	0.4	-0.5	-0.2	0.2	0.3
Bone: trabecular number	0.2	0.3	1.0	-0.7	-1.0	-0.5	-0.1	0.1	0.1
Bone: trabecular spacing	0.5	0.7	2.2	-0.2	0.8	1.5	-0.7	0.7	0.6
Bone: trabecular thickness	0.6	0.7	2.0	0.3	-0.7	-1.4	0.7	-0.7	-0.6
Bone: trabecular tissue density	0.2	0.3	0.8	-0.7	-0.9	0.3	-0.4	0.4	0.3
Breakpoint value in progressive ratio session	0.7	0.8	2.0	-0.1	-1.4	-1.0	0.8	-0.8	-0.7
Distance traveled before self-admin	1.0	1.1	2.4	-1.5	-1.5	0.3	-0.8	0.8	0.7
Distance traveled after self-admin	0.6	0.7	1.2	-0.9	0.1	0.2	-1.1	1.1	0.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	-0.4	-0.7	0.0	-0.3	0.3	-0.0
Delta time in open arm before/after self-admin	2.3	2.2	4.3	-2.1	-2.0	1.0	-1.0	1.0	1.2
Diff in mean of infusions in LGA sessions	0.8	0.9	1.9	0.1	-1.4	-1.2	0.8	-0.8	-0.9
Extinction: sum of active levers before priming	0.4	0.4	0.9	0.1	-0.8	-0.9	0.4	-0.4	-0.6
Active lever presses in extinction session 6	0.7	0.7	1.6	-0.8	-0.0	1.3	-0.8	0.8	0.7
Delta distance traveled before/after self-admin	0.4	0.5	1.8	0.8	1.4	-0.5	0.0	-0.0	-0.1
Delta ambulatory time before/after self-admin	0.5	0.5	2.2	0.4	1.5	0.1	-0.5	0.5	0.3
Time in closed arm before self-admin	0.6	0.7	1.6	-1.3	-1.2	0.6	-0.4	0.4	0.7
Time in closed arm after self-admin	0.5	0.5	1.4	-1.0	-1.2	0.6	-0.3	0.3	0.4
Time in open arm before self-admin	1.5	1.6	5.9	1.7	2.4	-0.8	0.2	-0.2	-0.4
Time in open arm after self-admin	0.8	0.9	1.3	-1.2	-0.7	0.9	-1.0	1.0	0.8
Sum of active levers in priming session hrs 5-6	1.3	1.3	2.2	-1.3	-0.4	0.8	-1.5	1.5	1.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.1	0.4	0.0	-0.4	0.4	0.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.0	0.5	0.1	-0.0	0.0	0.4
Time to tail flick, test, before self-admin	1.1	1.1	1.6	-0.6	0.8	0.9	-1.3	1.3	1.2
Time to tail flick, test, after self-admin	1.8	1.8	3.2	1.8	0.8	-0.8	1.4	-1.4	-1.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.8	0.8	0.6	-0.4	0.9	-0.9	-0.4
Delta time to tail flick, test, before/after SA	4.4	4.0	5.7	2.0	-0.2	-1.7	2.4	-2.4	-2.4
Ambulatory time before self-admin	0.7	0.7	1.3	-1.1	-0.4	0.3	-1.0	1.0	0.9
Ambulatory time after self-admin	0.3	0.4	0.5	-0.4	0.6	-0.4	-0.7	0.7	0.7
Total heroin consumption	0.3	0.3	1.0	0.1	-0.6	-1.0	0.4	-0.4	-0.5
Area under the delay curve	0.2	0.2	0.3	-0.3	0.3	0.6	-0.4	0.4	0.3
Delay disc. indifference point, 0s delay	1.8	1.9	3.5	1.9	1.4	-0.9	1.3	-1.3	-1.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	-0.5	-0.8	0.2	-0.1	0.1	-0.2
Delay disc. indifference point, 2s delay	1.0	1.1	1.9	1.4	1.2	-0.4	1.1	-1.1	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	-0.2	-0.4	-0.6	-0.2	0.2	-0.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	0.8	1.0	0.3	0.4	-0.4	-0.3
Delay disc. indifference point, 8s delay	1.9	1.9	2.7	-1.6	-0.1	1.2	-1.6	1.6	1.5
Delay discount exponential model param	0.1	0.1	0.2	0.4	-0.1	-0.5	0.4	-0.4	-0.3
Delay discount hyperbolic model param	0.1	0.1	0.2	0.1	-0.3	-0.5	0.2	-0.2	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.3	1.5	-0.5	-1.2	-0.1	0.2	-0.2	0.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.3	0.4	-0.1	0.1	-0.1	-0.5
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.0	-0.9	-0.2	0.4	-1.0	1.0	0.8
Bouts of movement, locomotor time 1	0.8	0.9	3.2	-0.1	-1.8	-0.3	0.8	-0.8	-0.8
Total resting periods, locomotor time 1	0.7	0.7	1.8	0.3	-1.3	-0.2	0.9	-0.9	-0.9
Rest time, locomotor task time 1	0.2	0.2	0.4	0.5	0.6	0.6	0.2	-0.2	-0.3
Distance moved, locomotor task time 1	2.0	2.2	3.5	-1.8	-0.2	0.6	-1.7	1.7	1.9
Vertical activity count, locomotor time 1	0.7	0.7	1.1	-0.9	0.2	0.7	-0.9	0.9	1.1
Time >=10cm from walls, locomotor time 2	0.8	0.8	3.0	0.2	1.7	0.3	-0.8	0.8	0.7
Bouts of movement, locomotor time 2	0.3	0.3	0.6	0.5	0.0	-0.6	0.6	-0.6	-0.8
Total resting periods, locomotor time 2	0.4	0.4	0.9	0.5	-0.3	-0.6	0.7	-0.7	-0.9
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.0	-0.1	0.7	-0.1	0.1	0.2
Distance moved, locomotor task time 2	0.3	0.3	0.5	-0.5	0.3	-0.3	-0.7	0.7	0.7
Vertical activity count, locomotor time 2	1.4	1.5	3.5	1.5	1.9	-1.2	0.8	-0.8	-0.9
Weight adjusted by age	0.5	0.6	1.0	0.1	-0.8	-1.0	0.7	-0.7	-0.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.6	-0.1	0.2	-0.7	0.7	0.3
Locomotion in novel chamber	9.0	11.1	14.9	3.2	-0.3	-3.4	3.8	-3.8	-3.9
Locomotion in novel chamber post-restriction	0.7	0.8	1.4	0.2	-1.0	-1.2	1.0	-1.0	-0.5
Progressive ratio	0.4	0.4	1.7	0.4	1.3	0.7	-0.4	0.4	0.1
Food seeking constrained by brief footshock	0.1	0.2	0.4	-0.3	-0.6	-0.6	0.1	-0.1	-0.2
Seeking ratio, punishment vs. effort	0.5	0.6	2.1	-0.8	-1.4	-0.7	0.0	-0.0	0.2
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.2	0.4	0.5	0.1	-0.1	0.2
Run reversals in cocaine runway, males	0.4	0.4	1.1	0.0	-1.0	-0.3	0.8	-0.8	-0.4
Latency to leave start box in cocaine runway	2.1	2.3	4.9	2.2	1.8	-0.9	1.2	-1.2	-1.4
Latency to leave start box in cocaine runway, F	0.6	0.6	1.6	1.3	1.1	-0.3	0.5	-0.5	-0.6
Latency to leave start box in cocaine runway, M	3.8	3.7	4.9	2.0	0.3	-2.1	2.1	-2.1	-2.2
Cd content in liver	0.0	0.1	0.1	-0.3	-0.2	0.1	-0.2	0.2	0.3
Co content in liver	0.9	1.0	1.8	0.7	-0.9	-0.0	1.3	-1.3	-1.1
Cu content in liver	0.4	0.4	0.8	-0.9	-0.5	0.0	-0.7	0.7	0.8
Fe content in liver	0.9	1.1	2.3	0.3	-1.3	-1.5	0.8	-0.8	-1.0
K content in liver	1.0	1.0	1.4	-1.2	-0.7	0.9	-1.0	1.0	1.1
Mg content in liver	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.0	0.0	0.1
Mn content in liver	1.6	1.8	2.8	1.5	0.0	-0.7	1.6	-1.6	-1.7
Na content in liver	0.8	0.8	2.0	-1.2	-1.4	0.1	-0.7	0.7	0.7
Rb content in liver	1.3	1.6	2.4	-1.2	0.2	1.6	-1.4	1.4	1.4
Se content in liver	0.4	0.5	1.8	0.4	-0.2	-1.3	0.5	-0.5	-0.5
Sr content in liver	0.5	0.5	0.7	-0.2	0.8	0.7	-0.7	0.7	0.7
Zn content in liver	0.2	0.3	1.0	0.0	1.0	0.1	-0.4	0.4	0.6