Hub : Genes

Mdc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000032813 0.62 0.08 0.0e+00 0.66 0.62 0.69 0.69 1.2e-96 1.5e-87 3.4e-107 1.3e-105
2 Adipose mRNA stability ENSRNOG00000032813 0.44 0.14 0.0e+00 0.44 0.42 0.46 0.47 8.2e-53 6.8e-51 7.0e-57 4.7e-58
3 BLA gene expression ENSRNOG00000032813 0.42 0.18 0.0e+00 0.3 0.27 0.28 0.29 3.3e-16 6.4e-15 1.3e-15 7.5e-16
4 BLA mRNA stability ENSRNOG00000032813 0.08 0.05 1.4e-03 0.06 0.04 0.01 0.05 6.3e-04 2.5e-03 7.5e-02 1.3e-03
5 Brain gene expression ENSRNOG00000032813 0.67 0.03 0.0e+00 0.32 0.36 0.34 0.36 1.1e-29 3.9e-35 5.4e-32 2.4e-34
6 Brain mRNA stability ENSRNOG00000032813 0.13 0.08 3.0e-10 0.08 0.1 0.11 0.07 1.1e-07 1.2e-09 4.7e-10 1.9e-07
7 Liver gene expression ENSRNOG00000032813 0.35 0.13 0.0e+00 0.31 0.32 0.32 0.32 4.6e-35 1.4e-36 4.9e-36 5.2e-36
8 Liver mRNA stability ENSRNOG00000032813 0.08 0.06 4.6e-08 0.06 0.06 0.06 0.07 1.7e-07 5.7e-07 1.2e-07 4.1e-08
9 NAcc gene expression ENSRNOG00000032813 0.22 0.11 9.2e-14 0.14 0.12 0.13 0.15 2.8e-10 3.4e-09 4.6e-10 1.9e-11
10 NAcc mRNA stability ENSRNOG00000032813 0.07 0.04 1.7e-04 0.07 0.04 0.04 0.06 8.3e-06 1.0e-03 6.2e-04 4.0e-05
11 PL gene expression ENSRNOG00000032813 0.23 0.1 0.0e+00 0.23 0.15 0.23 0.22 1.1e-17 8.7e-12 2.1e-17 8.0e-17
12 PL mRNA stability ENSRNOG00000032813 0.18 0.09 1.4e-09 0.11 0.11 0.13 0.12 7.0e-09 6.4e-09 7.7e-10 1.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
BMI with tail2.27.17.9-2.7-2.7-2.5-2.6-2.7-2.8-2.8-2.6-2.6-2.7-2.7-2.4
BMI without tail3.16.68.4-2.6-2.6-2.5-2.7-2.9-2.6-2.7-2.5-2.3-2.6-2.7-1.9
Body weight5.121.729.7-4.9-4.6-4.5-4.6-5.4-5.0-5.0-4.6-4.7-4.6-4.6-3.2
Epididymis fat weight6.715.824.0-3.9-4.1-4.0-4.1-2.7-3.7-3.6-3.9-4.3-4.1-4.0-4.9
Glucose3.85.811.72.32.42.32.41.72.02.12.22.72.42.53.4
Heart weight0.10.10.4-0.3-0.2-0.2-0.2-0.3-0.7-0.3-0.3-0.3-0.1-0.3-0.1
Left kidney weight3.610.313.1-3.4-3.2-2.9-2.9-3.6-3.4-3.3-3.2-3.4-3.3-3.1-2.4
Right kidney weight2.26.310.0-2.7-2.4-2.2-2.3-3.2-2.6-2.7-2.6-2.6-2.5-2.5-1.5
Tail length1.54.410.7-2.2-1.7-1.8-1.9-3.3-2.5-2.5-2.0-1.8-1.9-2.1-0.3
Length with tail2.17.514.3-2.9-2.4-2.5-2.5-3.8-3.2-3.1-2.7-2.8-2.5-2.7-1.1
Length without tail2.04.46.8-2.3-2.1-1.9-1.9-2.6-2.4-2.3-2.1-2.3-2.0-2.0-1.2
Liver weight, left0.10.10.80.0-0.1-0.2-0.1-0.40.0-0.2-0.00.10.10.10.9
Liver weight, right0.71.23.1-1.1-0.9-0.9-0.8-1.8-1.4-1.2-0.9-0.9-1.1-0.80.5
Parametrial fat weight2.75.26.2-2.5-2.2-1.9-2.0-2.4-2.4-2.3-2.3-2.5-2.5-2.3-2.2
Retroperitoneal fat weight0.51.52.0-1.2-1.3-1.4-1.2-1.2-1.2-1.2-1.0-1.4-1.3-1.2-1.0
Intraocular pressure0.81.11.81.11.01.00.91.11.31.11.01.01.01.10.8
Extensor digitorum longus weight0.00.10.50.20.30.30.4-0.00.10.20.30.40.20.40.7
Soleus weight0.41.14.80.81.10.91.10.10.50.60.81.21.11.02.2
Tibialis anterior weight0.20.61.6-0.7-0.7-0.7-0.7-0.4-0.6-0.6-0.8-0.6-0.8-0.8-1.3
Tibia length0.72.04.6-1.5-1.3-1.2-1.3-2.1-1.8-1.7-1.4-1.3-1.3-1.3-0.1
Number of licking bursts0.80.91.61.00.90.90.90.70.80.90.91.31.01.01.1
Food consumed during 24 hour testing period0.10.10.6-0.3-0.2-0.3-0.2-0.7-0.3-0.4-0.3-0.3-0.1-0.20.2
Times rat made contact with spout0.20.20.70.50.30.30.30.80.80.60.40.20.40.3-0.5
Mean time between licks in bursts1.52.04.61.31.51.51.50.71.11.21.31.51.51.52.1
Mean num. licks in bursts0.50.61.6-0.7-0.7-0.7-0.7-0.3-0.3-0.5-0.7-1.1-0.7-0.7-1.3
Std. dev. time between licks in bursts1.01.23.30.91.11.01.00.40.60.81.01.41.11.01.8
Water consumed over 24 hours0.00.00.10.20.20.20.20.10.00.20.20.30.30.20.2
Indifference point 0 sec1.11.72.6-1.1-1.5-1.6-1.4-1.0-0.9-1.2-1.1-1.3-1.2-1.4-1.6
Indifference point AUC1.92.22.8-1.5-1.4-1.5-1.7-1.7-1.6-1.6-1.6-1.3-1.2-1.4-1.0
Indifference point function ln k0.81.11.71.01.21.21.30.80.91.01.01.01.11.01.0
Indifference point function log k0.81.11.71.01.21.21.30.80.91.01.01.01.11.01.0
Delay discounting total patch changes 0 sec1.52.43.8-1.4-1.7-1.8-1.6-1.2-1.1-1.4-1.4-1.6-1.4-1.7-1.9
Delay discounting total patch changes 12 sec1.92.53.6-1.4-1.8-1.9-1.7-1.2-1.3-1.5-1.5-1.6-1.6-1.7-1.9
Delay discounting total patch changes 18 sec1.41.94.3-1.2-1.5-1.6-1.6-0.8-0.9-1.1-1.3-1.4-1.3-1.4-2.1
Delay discounting total patch changes 24 sec0.40.51.7-0.4-0.9-0.9-0.80.20.1-0.3-0.5-0.7-0.8-0.5-1.3
Delay discounting total patch changes 6 sec1.82.74.8-1.4-1.8-2.0-1.9-1.1-1.2-1.5-1.5-1.6-1.5-1.8-2.2
Delay discounting time to switch 0 sec0.10.10.3-0.1-0.3-0.1-0.10.4-0.10.1-0.0-0.4-0.40.0-0.6
Delay discounting water rate 0 sec0.40.71.2-0.9-0.7-0.7-0.7-1.0-0.9-0.9-0.9-0.7-0.6-1.1-0.8
Delay discounting water rate 12 sec0.00.00.2-0.2-0.1-0.0-0.10.00.2-0.1-0.2-0.2-0.1-0.5-0.4
Delay discounting water rate 18 sec0.10.10.3-0.3-0.1-0.4-0.4-0.60.0-0.5-0.3-0.10.2-0.4-0.2
Delay discounting water rate 24 sec1.82.43.2-1.7-1.4-1.3-1.3-1.8-1.6-1.7-1.6-1.6-1.4-1.8-1.5
Delay discounting water rate 6 sec0.10.20.7-0.5-0.10.1-0.1-0.3-0.3-0.4-0.3-0.5-0.5-0.6-0.8
Locomotor activity0.10.10.9-0.20.00.10.0-0.8-0.3-0.3-0.2-0.0-0.10.10.9
Locomotor testing distance0.00.00.40.00.00.10.0-0.10.00.00.00.2-0.10.20.6
Locomotor testing rearing0.10.10.3-0.2-0.2-0.1-0.2-0.5-0.3-0.3-0.1-0.2-0.3-0.10.5
Light reinforcement 10.30.50.9-0.8-0.7-0.4-0.5-0.5-0.7-0.7-0.5-1.0-0.9-0.9-0.9
Light reinforcement 20.20.30.7-0.6-0.5-0.3-0.3-0.9-0.5-0.7-0.4-0.6-0.6-0.6-0.1
Reaction time number correct0.60.92.3-1.0-0.9-0.9-0.7-0.6-1.0-0.8-0.8-1.1-0.9-1.1-1.5
Reaction time mean minus median2.02.76.31.61.51.51.50.81.71.41.81.51.51.82.5
Reaction time mean minus median AUC1.82.34.61.51.41.41.50.91.51.41.81.41.31.72.1
Reaction time num false alarms0.20.20.6-0.6-0.4-0.2-0.2-0.7-0.6-0.6-0.8-0.3-0.4-0.6-0.1
Reaction time num false alarms AUC0.30.50.9-0.8-0.6-0.4-0.5-0.8-0.8-0.9-0.9-0.5-0.6-0.7-0.2
Reaction time trials correct on left0.60.92.3-1.0-0.9-0.9-0.7-0.6-1.0-0.8-0.8-1.1-0.9-1.1-1.5
Reaction time trials on left0.60.92.2-1.0-0.8-0.9-0.7-0.6-1.0-0.8-0.7-1.1-0.9-1.0-1.5
Reaction time mean2.83.87.71.91.91.91.81.31.91.72.02.01.92.02.8
Reaction time mean AUC2.83.77.61.91.81.91.81.21.91.72.02.01.82.02.8
Median of all reaction times2.02.75.21.61.61.71.61.11.61.41.61.81.61.62.3
Reaction time omissions1.82.45.21.51.51.41.40.91.61.31.61.71.51.52.3
Reaction time false alarm rate0.10.10.4-0.10.00.20.0-0.3-0.2-0.3-0.40.30.1-0.00.6
Reaction time premature initiation rate1.62.12.9-1.5-1.5-1.4-1.6-1.5-1.5-1.5-1.5-1.4-1.7-1.3-1.2
Reaction time premature initiations2.83.94.8-2.1-2.0-2.0-1.9-1.8-2.0-1.9-1.9-2.0-2.2-1.9-2.0
Std. dev. reaction times1.92.66.91.61.41.41.50.81.51.31.71.61.41.72.6
Reaction time trials completed0.60.92.2-1.0-0.8-0.9-0.7-0.6-1.0-0.8-0.7-1.1-0.9-1.0-1.5
Reaction time trials AUC0.50.82.0-0.9-0.8-0.8-0.6-0.5-0.9-0.7-0.7-1.0-0.8-1.0-1.4
Social response proportion0.00.00.30.1-0.1-0.00.00.0-0.10.10.40.1-0.10.10.5
Social responses0.20.20.5-0.4-0.6-0.5-0.3-0.3-0.7-0.4-0.3-0.5-0.6-0.4-0.2
Social time0.81.03.70.90.80.91.00.40.70.70.91.00.71.21.9
Conditioned locomotion0.20.30.6-0.6-0.4-0.5-0.5-0.8-0.6-0.6-0.6-0.5-0.1-0.5-0.1
Cocaine response after cond. corrected0.30.40.60.60.60.60.50.70.70.60.60.60.60.50.3
Cocaine response after cond. not corrected0.00.00.20.20.20.20.1-0.10.1-0.00.20.30.30.10.4
Cocaine response before conditioning1.82.24.6-1.5-1.4-1.4-1.4-2.1-1.8-1.8-1.5-1.2-1.3-1.5-0.5
Saline control response2.43.23.9-1.9-1.8-1.7-1.8-1.6-1.8-1.6-1.8-1.9-1.7-1.8-2.0
Condit. Reinf. active minus inactive responses0.81.01.6-1.0-1.0-1.0-1.0-1.2-1.2-1.2-1.0-0.7-1.0-1.0-0.7
Condit. Reinf. active-inactive response ratio1.41.42.5-1.2-1.2-1.2-1.2-1.6-1.4-1.4-1.2-0.8-1.2-1.2-0.7
Condit. Reinf. active responses0.00.00.1-0.00.10.10.10.0-0.20.00.10.00.20.00.1
Condit. Reinf. inactive responses1.01.31.90.91.21.21.21.40.81.41.30.61.31.20.9
Condit. Reinf. lever presses0.30.40.50.50.70.70.60.70.30.70.60.60.70.60.4
Condit. Reinf. lever reinforcers received0.10.10.10.20.30.30.30.2-0.10.30.30.20.40.30.3
Pavlov. Cond. lever latency0.10.10.2-0.3-0.3-0.4-0.4-0.5-0.3-0.4-0.2-0.4-0.3-0.3-0.1
Pavlov. Cond. magazine entry latency0.20.30.6-0.3-0.6-0.5-0.5-0.8-0.2-0.6-0.70.0-0.6-0.5-0.3
Pavlov. Cond. change in total contacts0.40.50.8-0.6-0.8-0.7-0.7-0.7-0.5-0.7-0.9-0.4-0.7-0.7-0.9
Pavlov. Cond. index score0.00.00.1-0.1-0.1-0.1-0.1-0.10.0-0.1-0.20.2-0.1-0.1-0.2
Pavlov. Cond. latency score0.10.10.2-0.3-0.4-0.3-0.3-0.4-0.2-0.3-0.5-0.0-0.4-0.3-0.4
Pavlov. Cond. lever contacts0.00.00.3-0.1-0.2-0.2-0.20.10.0-0.0-0.3-0.1-0.2-0.2-0.5
Pavlov. Cond. magazine entry number0.30.30.50.40.70.60.60.70.10.60.70.20.70.60.6
Pavlov. Cond. intertrial magazine entries2.73.54.71.72.02.01.91.71.41.82.01.52.01.92.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.1-0.1-0.1-0.1-0.20.0-0.1-0.30.1-0.2-0.1-0.2
Pavlov. Cond. response bias0.00.00.20.20.00.10.10.10.40.1-0.10.4-0.00.1-0.1
Conditioned reinforcement - actives0.50.51.1-0.6-0.5-1.0-0.9-0.7-0.6-0.6-0.6-0.5-0.4-0.6-0.8
Conditioned reinforcement - inactives1.82.04.4-1.2-1.5-2.1-1.8-1.3-1.2-1.3-1.2-1.2-0.9-1.4-1.4
Conditioned locomotion0.00.00.1-0.00.2-0.3-0.2-0.1-0.10.00.10.10.30.00.0
Intermittent access intake day 1-15 change0.60.51.1-0.7-0.5-0.5-0.6-1.0-0.6-0.8-0.7-0.7-0.4-0.9-1.1
Intermittent access intake escalation0.10.00.3-0.20.10.1-0.0-0.5-0.1-0.2-0.1-0.20.1-0.3-0.2
Intermittent access intake escalation 20.80.81.10.81.01.01.10.20.80.70.80.91.00.81.0
Intermitt. access day 1 inactive lever presses0.00.00.1-0.10.20.1-0.0-0.2-0.3-0.1-0.00.20.40.00.3
Intermitt. access day 15 inactive lever presses2.52.83.5-1.8-1.6-1.6-1.7-1.9-1.7-1.8-1.8-1.6-1.4-1.8-1.3
Intermitt. access escalation Index2.82.53.31.61.31.51.81.81.71.81.61.41.21.71.3
Intermittent access day 1 total infusions0.30.30.70.70.3-0.3-0.10.80.80.60.50.60.60.50.4
Intermittent access day 15 total infusions0.00.00.20.30.3-0.1-0.20.20.40.20.20.20.30.1-0.1
Intermittent access terminal intake (last 3 days)0.10.10.3-0.2-0.2-0.5-0.5-0.3-0.1-0.3-0.2-0.2-0.1-0.3-0.5
Intermittent access total infusions0.00.00.20.0-0.0-0.5-0.50.00.1-0.0-0.00.00.0-0.1-0.2
Intermittent access day 1 locomotion0.50.51.20.80.4-0.00.10.60.90.70.70.80.60.71.1
Intermittent access day 15 total locomotion0.10.10.6-0.3-0.0-0.4-0.6-0.8-0.3-0.5-0.2-0.10.2-0.40.1
Intermittent access total locomotion0.10.10.3-0.1-0.1-0.6-0.5-0.6-0.2-0.3-0.1-0.1-0.0-0.20.2
Intermittent access standard deviation3.33.54.0-1.9-1.7-1.8-1.8-1.9-2.0-1.9-1.8-1.9-1.8-1.9-2.0
Cocaine induced anxiety4.14.75.52.22.22.22.21.92.42.12.22.22.02.12.3
Post-drug Anxiety1.41.62.21.21.31.51.41.11.11.31.21.31.11.21.3
Baseline Anxiety0.40.41.0-0.7-0.6-0.5-0.5-0.4-0.9-0.6-0.7-0.5-0.5-0.6-1.0
Lifetime Intake0.10.10.40.1-0.1-0.5-0.60.00.1-0.0-0.00.10.1-0.1-0.1
Incentive Sensitization - Responses0.50.51.00.80.81.00.60.80.80.70.70.60.80.70.3
Incentive Sensitization - Breakpoint0.70.71.40.91.01.20.80.90.90.80.80.80.90.80.4
Progressive ratio test 1 active lever presses0.10.10.30.40.1-0.4-0.20.50.60.40.40.40.30.40.1
Progressive ratio test 1 breakpoint0.10.10.30.40.0-0.4-0.30.40.50.30.30.40.30.40.0
Progressive ratio test 1 inactive lever presses0.20.20.9-0.2-0.2-0.9-0.8-0.1-0.2-0.3-0.3-0.10.4-0.3-0.8
Progressive ratio test 2 active lever presses0.40.40.80.80.70.30.10.80.90.70.70.70.80.70.2
Progressive ratio test 2 breakpoint0.70.71.41.01.00.60.31.01.20.90.90.81.00.80.2
Progressive ratio test 2 inactive lever presses0.20.30.9-0.3-0.4-0.9-0.9-0.6-0.3-0.5-0.4-0.3-0.1-0.3-0.3
Total sessions with >9 infusions0.10.10.6-0.0-0.2-0.8-0.6-0.10.0-0.2-0.20.10.4-0.1-0.1
Short access day 1 total inactive lever presses0.40.41.10.50.70.50.50.10.40.30.50.80.90.51.1
Short access day 10 total inactive lever presses0.10.10.40.20.40.40.40.00.20.30.20.40.60.20.5
Short access day 1 total infusions0.40.40.50.70.60.50.40.70.70.60.60.70.70.70.6
Short access day 10 total infusions0.20.20.7-0.1-0.2-0.8-0.9-0.3-0.2-0.4-0.2-0.1-0.1-0.4-0.5
Short access total infusions0.10.10.6-0.1-0.3-0.7-0.8-0.2-0.1-0.3-0.2-0.0-0.0-0.3-0.2
Short access day 1 locomotion3.63.94.82.12.01.61.72.12.12.02.02.22.11.91.7
Short access day 10 total locomotion0.20.20.50.40.40.20.50.20.20.30.50.70.20.40.7
Short access total locomotion0.30.30.70.60.50.10.30.60.50.50.60.80.60.60.7
Compulsive drug intake3.23.24.21.81.71.71.82.01.72.01.71.81.61.91.6
One hour access (0.3 mA shock)0.60.71.41.00.60.20.30.91.20.90.90.90.90.90.6
One hour access (shock baseline)0.40.40.9-0.5-0.7-0.9-0.9-0.9-0.3-0.6-0.5-0.6-0.6-0.5-0.4
Number of responses in last shaping day0.10.10.4-0.1-0.1-0.6-0.6-0.3-0.3-0.3-0.10.10.3-0.2-0.0
Context. condit. distance diff. score9.311.412.93.33.43.53.53.13.13.33.53.33.33.53.6
Locomotion velocity, session 10.40.40.70.50.80.80.60.50.40.60.70.40.70.70.9
Locomotion distance, session 10.00.00.20.10.10.1-0.10.40.30.20.00.10.20.0-0.3
Locomotion velocity, session 20.10.10.20.40.30.30.20.10.40.20.30.40.30.30.4
Locomotion distance, session 20.20.30.60.60.60.50.40.60.80.50.40.60.70.50.3
Locomotion velocity, session 30.30.40.8-0.7-0.5-0.6-0.6-0.4-0.7-0.4-0.5-0.9-0.5-0.6-0.8
Locomotion distance, session 31.21.41.81.21.21.11.11.31.31.21.21.11.31.10.8
Stereotopy head waving bouts, day 30.50.51.4-0.7-0.7-0.7-0.7-1.2-0.8-0.9-0.8-0.5-0.7-0.7-0.1
Stereotopy head waving duration, day 30.50.61.3-0.9-0.7-0.6-0.7-1.1-1.1-0.9-0.8-0.8-0.7-0.7-0.3
Locomotion velocity, session 74.44.86.12.32.22.12.12.32.52.32.22.12.22.21.8
Locomotion distance, session 73.34.26.82.22.01.92.02.32.62.11.92.12.01.91.3
Stereotopy head waving bouts, day 71.72.02.9-1.3-1.5-1.4-1.4-1.6-1.2-1.5-1.4-1.2-1.7-1.4-1.1
Stereotopy head waving duration, day 72.12.53.5-1.5-1.7-1.5-1.6-1.9-1.5-1.7-1.6-1.4-1.8-1.6-1.1
Locomotion velocity, session 81.82.14.91.41.41.51.40.71.21.11.51.61.51.52.2
Locomotion distance, session 85.17.78.52.92.82.82.72.52.82.72.82.92.72.82.8
Degree of sensitization distance0.80.81.00.90.90.90.90.80.80.80.91.00.80.91.0
Degree of sensitization stereotypy1.21.32.1-0.9-1.3-1.1-1.2-1.3-0.7-1.2-1.2-0.8-1.5-1.2-1.0
Condit. Reinf. active minus inactive responses0.91.01.30.91.11.01.01.01.01.00.91.01.11.00.8
Condit. Reinf. active-inactive response ratio0.10.10.2-0.3-0.3-0.3-0.3-0.1-0.3-0.2-0.3-0.3-0.3-0.3-0.5
Condit. Reinf. active responses1.21.42.11.11.31.11.11.31.21.21.31.11.41.10.9
Condit. Reinf. inactive responses1.21.42.01.21.21.01.11.41.41.31.30.91.41.10.6
Incentive salience index mean2.93.54.41.91.91.81.81.62.01.71.82.12.01.81.9
Condit. Reinf. lever presses4.96.68.02.62.62.52.52.22.72.42.52.82.72.52.7
Time in familiar zone, hab. session 10.70.61.90.70.70.70.71.41.01.00.70.40.70.7-0.1
Time in novel zone, hab. session 10.30.30.9-0.5-0.3-0.3-0.3-0.9-0.9-0.6-0.3-0.4-0.3-0.30.4
Total zone transitions, hab. session 10.40.60.90.70.80.80.70.90.70.80.80.70.80.80.5
Total locomotion distance, hab. session 10.30.40.80.70.70.60.60.80.90.70.60.70.70.60.3
Locomotion velocity, hab. session 10.10.10.30.30.20.10.20.50.50.30.20.30.30.2-0.1
Time in familiar zone, hab. session 20.00.00.10.10.10.10.10.40.10.20.1-0.00.20.1-0.2
Time in novel zone, hab. session 20.20.20.5-0.6-0.4-0.4-0.4-0.6-0.7-0.5-0.4-0.7-0.4-0.4-0.1
Total zone transitions, hab. session 20.10.10.2-0.2-0.3-0.3-0.4-0.0-0.1-0.2-0.2-0.1-0.4-0.3-0.4
Total locomotion distance, hab. session 20.60.81.30.90.90.80.81.21.11.00.80.80.90.80.5
Locomotion velocity, hab. session 20.71.01.71.11.00.90.91.21.31.10.91.00.90.90.6
Novel to familiar place preference ratio0.10.10.2-0.1-0.3-0.3-0.3-0.20.0-0.2-0.3-0.0-0.3-0.4-0.4
Novelty place preference0.10.10.2-0.2-0.4-0.5-0.4-0.4-0.2-0.4-0.4-0.2-0.4-0.5-0.5
Time in novel zone, NPP test0.20.20.3-0.3-0.5-0.5-0.5-0.5-0.3-0.5-0.5-0.2-0.5-0.5-0.5
Total zone transitions, NPP test0.91.31.71.11.21.11.11.31.21.21.21.11.21.20.9
Total locomotion distance, NPP test0.60.81.30.90.90.80.91.21.11.00.80.80.90.80.4
Locomotion velocity, NPP test1.11.52.41.31.21.11.21.61.51.41.11.11.21.10.6
Pavlov. Cond. lever latency3.34.26.7-2.3-1.9-1.8-1.8-1.4-2.4-1.6-2.0-2.6-2.0-1.9-2.5
Pavlov. Cond. magazine entry latency3.14.06.02.02.01.92.01.52.01.82.12.21.92.02.4
Pavlov. Cond. change in total contacts0.20.20.70.50.30.20.2-0.30.6-0.00.30.80.30.30.8
Pavlov. Cond. index score4.15.37.62.52.22.12.21.62.61.92.32.72.22.22.8
Pavlov. Cond. latency score3.34.27.12.31.91.81.91.32.41.62.02.71.91.92.5
Pavlov. Cond. lever contacts2.32.75.31.91.51.31.40.92.11.21.52.31.51.52.1
Pavlov. Cond. magazine entry number3.34.25.4-1.9-2.1-2.0-2.1-1.8-1.8-2.0-2.2-1.9-2.1-2.1-2.3
Pavlov. Cond. intertrial magazine entries0.10.20.7-0.4-0.1-0.2-0.30.3-0.4-0.0-0.2-0.80.0-0.3-0.8
Pavlov. Cond. lever-magazine prob. diff.4.35.47.72.52.22.22.21.72.62.02.42.72.22.32.8
Pavlov. Cond. response bias4.25.27.42.32.32.22.21.82.32.02.32.42.32.32.7
Bone: apparent density0.61.02.31.10.90.90.81.31.51.10.91.00.90.90.3
Bone surface0.00.00.10.1-0.1-0.1-0.2-0.30.3-0.2-0.20.20.0-0.10.1
Bone volume0.10.10.2-0.2-0.5-0.4-0.5-0.40.2-0.4-0.5-0.1-0.3-0.5-0.5
Bone: connectivity density2.23.54.51.81.91.91.82.12.02.01.91.52.01.91.5
Bone: cortical apparent density1.62.13.0-1.4-1.5-1.5-1.5-1.0-1.3-1.3-1.5-1.6-1.3-1.5-1.7
Bone: cortical area1.82.73.7-1.4-1.8-1.8-1.8-1.9-1.0-1.9-1.9-1.1-1.7-1.8-1.4
Bone: cortical porosity0.80.91.2-0.9-1.0-1.1-1.0-0.9-0.9-1.0-1.0-0.8-0.9-1.0-1.0
Bone: cortical porosity0.30.40.6-0.6-0.6-0.7-0.6-0.8-0.6-0.7-0.6-0.4-0.5-0.6-0.3
Bone: cortical thickness5.49.011.3-2.7-3.3-3.2-3.2-2.7-2.1-3.1-3.2-2.5-3.1-3.2-3.4
Bone: cortical thickness2.22.64.1-1.5-1.7-1.8-1.8-1.2-1.3-1.4-1.6-1.6-1.5-1.6-2.0
Bone: cortical tissue density1.31.72.4-1.4-1.3-1.4-1.4-0.9-1.3-1.1-1.3-1.5-1.1-1.3-1.5
Bone: elastic displacement0.50.61.3-0.8-0.7-0.7-0.7-0.5-0.7-0.6-0.7-1.1-0.8-0.7-0.9
Bone: elastic work2.22.83.2-1.5-1.8-1.8-1.8-1.7-1.3-1.8-1.7-1.6-1.7-1.7-1.6
Bone: endosteal estimation0.20.51.9-0.6-0.1-0.1-0.2-1.4-1.2-0.7-0.3-0.4-0.2-0.21.1
Bone: endosteal perimeter0.91.95.61.11.51.51.40.50.61.01.31.31.41.42.4
Bone: final force6.911.412.9-3.1-3.5-3.5-3.6-3.5-2.7-3.6-3.5-2.9-3.5-3.6-3.3
Bone: final moment6.110.011.5-2.9-3.3-3.3-3.4-3.4-2.5-3.4-3.3-2.7-3.3-3.4-3.0
Bone: marrow area0.20.51.9-0.7-0.2-0.1-0.2-1.4-1.3-0.7-0.3-0.5-0.2-0.21.1
Bone: maximum diameter0.10.21.20.40.30.30.3-0.40.5-0.00.10.80.30.31.1
Bone: maximum force5.39.311.0-2.8-3.2-3.2-3.3-3.3-2.5-3.3-3.2-2.6-3.1-3.2-2.8
Bone: maximum moment4.78.19.9-2.7-3.0-3.0-3.0-3.2-2.3-3.1-3.0-2.5-2.8-3.0-2.6
Bone: minimum diameter0.10.21.50.30.40.40.3-0.40.2-0.00.20.60.50.31.2
Bone: periosteal estimation0.81.74.0-1.3-1.2-1.2-1.3-2.0-1.5-1.6-1.4-1.0-1.1-1.2-0.2
Bone: periosteal perimeter0.10.20.9-0.3-0.3-0.3-0.3-0.9-0.3-0.6-0.5-0.0-0.3-0.30.4
Bone: post-yield work0.60.82.00.71.11.00.90.40.50.70.90.81.10.91.4
Bone: stiffness1.72.63.1-1.5-1.7-1.7-1.7-1.6-1.2-1.7-1.7-1.4-1.6-1.7-1.7
Bone: tissue strength4.64.45.4-1.9-2.2-2.2-2.2-2.3-1.6-2.3-2.2-1.7-2.3-2.2-2.0
Bone: trabecular number0.60.92.51.10.80.80.71.31.61.00.80.90.90.80.2
Bone: trabecular spacing2.43.14.9-1.7-1.8-1.8-1.7-2.2-2.0-2.0-1.7-1.3-1.8-1.7-1.0
Bone: trabecular thickness0.60.71.50.90.70.80.71.01.20.90.70.80.80.70.3
Bone: trabecular tissue density1.82.63.2-1.5-1.7-1.6-1.7-1.8-1.4-1.7-1.7-1.3-1.7-1.7-1.5
Breakpoint value in progressive ratio session1.01.11.51.10.91.01.01.21.21.11.01.11.01.21.0
Distance traveled before self-admin0.30.30.40.50.60.60.50.20.60.40.60.50.60.50.6
Distance traveled after self-admin0.00.00.2-0.10.10.20.1-0.3-0.2-0.20.4-0.2-0.1-0.10.4
Delta time in closed arm before/after self-admin0.20.20.2-0.4-0.4-0.4-0.4-0.3-0.5-0.4-0.5-0.2-0.4-0.4-0.2
Delta time in open arm before/after self-admin0.10.10.2-0.1-0.4-0.5-0.2-0.2-0.1-0.20.0-0.2-0.3-0.2-0.3
Diff in mean of infusions in LGA sessions2.83.14.31.91.71.71.82.12.01.81.81.81.71.60.9
Extinction: sum of active levers before priming0.30.30.70.60.30.20.40.80.60.50.50.80.80.50.3
Active lever presses in extinction session 60.10.10.3-0.2-0.30.0-0.10.0-0.2-0.10.1-0.4-0.4-0.2-0.5
Delta distance traveled before/after self-admin1.11.11.5-1.1-1.1-1.1-1.0-1.1-1.2-1.1-0.7-1.2-1.0-1.2-0.7
Delta ambulatory time before/after self-admin0.20.20.4-0.5-0.6-0.5-0.3-0.5-0.6-0.5-0.3-0.6-0.6-0.50.0
Time in closed arm before self-admin0.00.00.1-0.00.20.30.00.1-0.10.0-0.00.00.10.2-0.1
Time in closed arm after self-admin1.11.21.7-1.1-1.1-1.0-1.3-0.9-1.1-1.1-1.0-1.0-1.0-1.1-1.1
Time in open arm before self-admin0.60.71.30.90.60.50.70.61.00.80.80.80.90.81.2
Time in open arm after self-admin0.91.01.61.20.50.30.91.01.21.21.31.00.71.11.2
Sum of active levers in priming session hrs 5-60.50.50.80.60.60.80.70.80.60.60.70.70.90.50.6
Time to tail flick, vehicle, before self-admin0.30.40.60.60.70.50.60.40.70.50.50.60.70.60.6
Time to tail flick, vehicle, after self-admin1.71.82.41.41.41.51.41.01.21.31.21.51.51.41.4
Time to tail flick, test, before self-admin0.20.20.5-0.2-0.5-0.6-0.7-0.4-0.2-0.3-0.3-0.4-0.3-0.5-0.5
Time to tail flick, test, after self-admin2.22.23.31.61.51.51.31.11.71.41.41.51.81.31.7
Delta time to tail flick, vehicle, before/after SA0.70.71.40.80.81.20.90.80.70.90.70.80.60.90.8
Delta time to tail flick, test, before/after SA1.51.31.91.11.31.41.31.11.31.10.91.11.21.10.9
Ambulatory time before self-admin0.00.00.30.10.1-0.1-0.2-0.10.10.10.10.20.50.10.1
Ambulatory time after self-admin0.00.00.2-0.0-0.10.10.2-0.2-0.1-0.10.3-0.1-0.10.00.5
Total heroin consumption0.00.00.10.20.20.10.30.10.30.20.00.20.40.20.1
Area under the delay curve2.12.33.6-1.4-1.5-1.6-1.9-1.5-1.6-1.6-1.3-1.4-1.3-1.5-1.3
Delay disc. indifference point, 0s delay0.10.10.3-0.3-0.2-0.4-0.5-0.5-0.4-0.5-0.2-0.1-0.1-0.2-0.1
Delay disc. indifference point, 16s delay2.82.95.1-1.4-1.7-2.0-2.3-1.4-1.6-1.7-1.4-1.6-1.2-1.8-2.0
Delay disc. indifference point, 2s delay1.51.62.3-1.4-1.2-1.2-1.3-1.4-1.5-1.4-1.2-1.1-1.5-1.1-0.8
Delay disc. indifference point, 24s delay0.90.91.5-0.8-1.0-1.1-1.2-0.7-0.9-0.9-0.9-0.8-0.8-1.0-0.9
Delay disc. indifference point, 4s delay1.61.72.8-1.2-1.2-1.4-1.4-1.7-1.5-1.5-0.9-1.2-1.1-1.3-0.9
Delay disc. indifference point, 8s delay0.30.30.6-0.5-0.6-0.7-0.8-0.6-0.6-0.7-0.5-0.5-0.5-0.5-0.5
Delay discount exponential model param2.12.33.51.41.51.61.91.51.61.61.31.41.31.51.4
Delay discount hyperbolic model param2.02.13.21.41.41.51.81.51.61.51.21.41.41.41.3
Fecal boli incidents, locomotor time 10.60.70.90.80.80.70.91.00.90.90.50.80.50.90.9
Change in fecal boli incidents, locomotor task0.40.40.9-0.7-0.6-0.2-0.6-0.6-1.0-0.7-0.5-0.5-0.8-0.7-0.3
Time >=10cm from walls, locomotor time 10.10.10.5-0.3-0.2-0.2-0.4-0.5-0.7-0.20.1-0.2-0.50.00.3
Bouts of movement, locomotor time 12.02.23.01.71.51.31.41.31.61.41.51.61.71.41.4
Total resting periods, locomotor time 11.41.62.51.51.20.91.11.01.31.11.41.41.61.11.3
Rest time, locomotor task time 10.40.41.50.60.70.40.50.30.50.50.60.70.80.51.2
Distance moved, locomotor task time 11.11.21.5-1.1-1.1-1.0-1.1-1.0-1.1-1.1-1.0-1.2-1.2-1.1-1.2
Vertical activity count, locomotor time 10.91.01.8-1.1-1.0-0.8-0.6-0.8-0.9-0.8-1.0-1.2-1.3-0.7-1.3
Time >=10cm from walls, locomotor time 20.10.10.2-0.10.00.30.10.0-0.30.20.1-0.1-0.30.50.3
Bouts of movement, locomotor time 20.10.10.5-0.2-0.10.30.2-0.5-0.2-0.1-0.2-0.2-0.30.30.7
Total resting periods, locomotor time 20.20.21.30.20.30.60.6-0.20.20.30.30.20.00.71.1
Rest time, locomotor task time 21.82.13.91.31.51.71.70.81.01.31.41.41.31.52.0
Distance moved, locomotor task time 21.61.93.1-1.4-1.4-1.5-1.4-1.0-1.3-1.3-1.1-1.4-1.4-1.4-1.8
Vertical activity count, locomotor time 20.30.41.0-0.6-0.6-0.6-0.4-0.3-0.5-0.5-0.5-0.6-0.7-0.6-1.0
Weight adjusted by age2.22.53.6-1.7-1.5-1.3-1.4-1.9-1.9-1.8-1.6-1.6-1.7-1.5-0.9
Seeking ratio, delayed vs. immediate footshock0.40.51.0-0.6-0.6-1.0-0.9-0.8-0.7-0.7-0.8-0.6-0.6-0.5-0.3
Locomotion in novel chamber0.50.60.9-0.7-0.9-1.0-0.7-0.9-0.8-0.9-0.6-0.8-0.8-0.8-0.4
Locomotion in novel chamber post-restriction0.80.91.2-1.0-0.9-0.8-0.9-0.9-1.1-1.0-1.0-1.0-1.1-1.1-0.9
Progressive ratio5.56.47.1-2.6-2.6-2.7-2.4-2.6-2.7-2.5-2.6-2.6-2.5-2.4-2.0
Food seeking constrained by brief footshock0.00.00.20.1-0.3-0.3-0.00.10.20.10.1-0.1-0.40.20.1
Seeking ratio, punishment vs. effort4.45.46.32.42.22.42.42.52.52.42.42.42.12.31.8
Run reversals in cocaine runway, females0.50.51.0-0.6-0.7-1.0-0.8-0.4-0.6-0.6-0.7-0.7-0.4-0.8-1.0
Run reversals in cocaine runway, males0.20.21.5-0.1-0.20.00.1-0.4-0.10.00.1-0.0-0.30.41.2
Latency to leave start box in cocaine runway0.10.10.7-0.4-0.50.1-0.2-0.1-0.4-0.3-0.4-0.3-0.8-0.2-0.1
Latency to leave start box in cocaine runway, F0.30.30.60.60.30.80.40.70.60.60.60.60.20.60.7
Latency to leave start box in cocaine runway, M2.32.23.0-1.6-1.5-1.2-1.0-1.3-1.7-1.5-1.5-1.5-1.7-1.6-1.4
Cd content in liver0.91.01.5-0.9-1.0-1.1-1.1-0.9-0.7-1.0-1.2-1.0-0.9-1.1-1.2
Co content in liver2.93.44.7-2.0-1.8-1.8-1.8-1.5-2.2-1.7-1.7-2.0-1.7-1.7-2.0
Cu content in liver0.91.02.60.91.01.11.01.61.11.31.00.60.90.90.0
Fe content in liver1.21.42.5-1.3-1.2-1.1-1.0-0.9-1.3-1.0-1.1-1.6-1.4-1.0-1.3
K content in liver0.20.20.60.60.50.30.30.50.60.40.30.80.70.30.3
Mg content in liver4.44.65.92.22.22.12.01.92.12.02.12.42.42.02.3
Mn content in liver4.24.88.32.02.42.32.31.71.62.02.22.12.42.32.9
Na content in liver0.20.20.30.1-0.4-0.5-0.5-0.30.5-0.4-0.50.3-0.4-0.4-0.6
Rb content in liver0.81.11.31.01.11.01.11.11.01.10.91.01.21.00.7
Se content in liver3.23.96.42.02.02.01.91.51.91.71.92.11.91.92.5
Sr content in liver0.10.10.3-0.3-0.3-0.4-0.4-0.5-0.3-0.4-0.2-0.1-0.3-0.30.1
Zn content in liver0.00.00.10.10.20.20.20.2-0.00.20.30.20.10.20.3