Hub : Genes

Plcl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000032659	0.03	0.02	3.5e-04	0.03	0.03	0.02	0.03	1.7e-04	4.4e-04	9.1e-04	3.0e-04
2	Brain	mRNA stability	ENSRNOG00000032659	0.04	0.03	5.5e-05	0.04	0.04	0.04	0.04	1.6e-04	1.4e-04	2.9e-04	9.7e-05
3	Eye	gene expression	ENSRNOG00000032659	0.67	0.16	6.1e-05	0.11	0.16	0.11	0.17	8.3e-03	2.0e-03	9.4e-03	1.5e-03
4	PL	gene expression	ENSRNOG00000032659	0.03	0.02	6.9e-03	0.01	0.01	0	0	1.0e-01	4.0e-02	2.8e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	1.6	5.3	7.8	1.2	-2.7	-2.1	-2.8
BMI without tail	0.1	0.1	0.4	-0.3	-0.1	-0.1	0.6
Body weight	1.2	5.0	6.5	-2.3	1.9	2.1	2.5
Epididymis fat weight	1.1	2.6	5.4	-1.0	1.5	1.3	2.3
Glucose	0.2	0.4	0.5	0.2	-0.7	-0.7	0.7
Heart weight	0.1	0.2	0.3	-0.4	0.3	0.4	-0.5
Left kidney weight	0.2	0.6	0.8	-0.8	0.8	0.9	0.4
Right kidney weight	0.6	1.8	3.1	-1.8	1.2	1.5	0.5
Tail length	6.6	20.0	35.1	-3.0	4.6	3.8	5.9
Length with tail	7.7	28.3	41.0	-4.2	5.5	5.0	6.4
Length without tail	0.9	2.0	2.4	-1.3	1.4	1.6	1.4
Liver weight, left	2.1	3.4	4.6	-1.8	2.1	2.0	1.4
Liver weight, right	2.2	3.6	4.4	-2.1	1.8	2.0	1.6
Parametrial fat weight	0.0	0.0	0.0	0.0	-0.2	-0.0	0.0
Retroperitoneal fat weight	0.1	0.3	0.7	-0.8	0.0	0.4	0.7
Intraocular pressure	2.8	3.9	4.4	1.8	-2.1	-2.0	-2.0
Extensor digitorum longus weight	1.0	4.0	6.7	1.6	-2.6	-2.3	-1.2
Soleus weight	0.2	0.5	0.9	-0.9	0.5	0.8	0.3
Tibialis anterior weight	0.4	1.5	2.5	1.1	-1.6	-1.3	-0.8
Tibia length	3.4	9.5	16.3	-1.9	3.3	2.6	4.0
Number of licking bursts	0.3	0.3	1.0	0.1	-0.5	-0.3	-1.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	-0.2	-0.3	0.2
Times rat made contact with spout	0.2	0.2	0.3	0.6	-0.1	-0.5	0.4
Mean time between licks in bursts	0.4	0.5	0.9	0.8	-0.6	-0.9	0.2
Mean num. licks in bursts	0.2	0.2	0.6	0.4	0.2	-0.2	0.7
Std. dev. time between licks in bursts	2.1	2.5	3.0	1.3	-1.7	-1.7	-1.5
Water consumed over 24 hours	0.7	0.8	1.2	0.9	-0.8	-0.9	-1.1
Indifference point 0 sec	0.6	1.0	3.7	0.1	-0.3	-0.1	-1.9
Indifference point AUC	0.1	0.1	0.2	-0.2	0.4	0.3	0.3
Indifference point function ln k	0.6	0.8	2.7	-0.1	-0.7	-0.2	-1.6
Indifference point function log k	0.6	0.8	2.7	-0.1	-0.7	-0.2	-1.6
Delay discounting total patch changes 0 sec	0.7	1.1	4.0	0.2	-0.5	-0.3	-2.0
Delay discounting total patch changes 12 sec	0.4	0.5	1.8	0.2	-0.2	-0.1	-1.3
Delay discounting total patch changes 18 sec	1.4	1.9	3.2	1.2	-1.2	-1.1	-1.8
Delay discounting total patch changes 24 sec	0.1	0.1	0.1	-0.3	0.2	0.3	0.0
Delay discounting total patch changes 6 sec	0.5	0.7	1.3	-1.1	0.5	0.8	-0.7
Delay discounting time to switch 0 sec	0.2	0.3	1.0	0.4	-0.2	-0.4	1.0
Delay discounting water rate 0 sec	0.3	0.5	1.0	-1.0	0.5	0.8	0.1
Delay discounting water rate 12 sec	0.7	1.1	1.7	-1.3	0.3	1.0	-1.3
Delay discounting water rate 18 sec	0.2	0.3	0.5	-0.6	0.5	0.7	-0.3
Delay discounting water rate 24 sec	1.2	1.6	3.0	-1.7	0.9	1.2	1.1
Delay discounting water rate 6 sec	0.0	0.1	0.2	-0.4	0.0	0.3	-0.2
Locomotor activity	0.1	0.1	0.4	0.6	0.0	-0.2	0.1
Locomotor testing distance	0.1	0.2	0.5	0.5	0.1	-0.1	-0.7
Locomotor testing rearing	0.2	0.3	0.3	-0.4	0.5	0.5	0.6
Light reinforcement 1	1.3	2.4	4.4	0.9	-2.1	-1.5	-1.4
Light reinforcement 2	0.2	0.2	0.5	-0.6	0.0	0.3	-0.7
Reaction time number correct	0.2	0.3	0.7	-0.2	-0.5	0.0	-0.9
Reaction time mean minus median	0.3	0.4	1.1	0.6	-0.1	-0.5	1.0
Reaction time mean minus median AUC	0.1	0.2	0.3	0.5	0.0	-0.4	0.6
Reaction time num false alarms	1.7	2.3	3.6	1.2	-1.9	-1.6	-1.4
Reaction time num false alarms AUC	1.7	2.4	3.8	1.2	-2.0	-1.6	-1.3
Reaction time trials correct on left	0.2	0.3	0.7	-0.2	-0.5	0.0	-0.9
Reaction time trials on left	0.2	0.2	0.6	-0.3	-0.5	0.0	-0.8
Reaction time mean	0.6	0.8	2.1	0.9	0.4	-0.3	1.5
Reaction time mean AUC	0.6	0.8	1.7	1.1	0.1	-0.6	1.3
Median of all reaction times	0.5	0.7	1.6	1.0	0.4	-0.3	1.3
Reaction time omissions	0.2	0.2	0.7	0.3	0.3	-0.1	0.8
Reaction time false alarm rate	1.0	1.4	2.0	1.1	-1.4	-1.4	-0.7
Reaction time premature initiation rate	2.7	3.6	8.9	1.4	-1.4	-1.1	-3.0
Reaction time premature initiations	2.6	3.8	10.0	1.2	-1.6	-1.1	-3.2
Std. dev. reaction times	0.5	0.7	2.1	-0.0	0.8	0.3	1.4
Reaction time trials completed	0.2	0.2	0.6	-0.3	-0.5	0.0	-0.8
Reaction time trials AUC	0.2	0.2	0.6	-0.2	-0.6	-0.1	-0.8
Social response proportion	3.9	4.3	5.3	-2.0	2.3	2.2	1.7
Social responses	1.2	1.5	2.4	-1.1	1.1	1.1	1.6
Social time	0.2	0.2	0.7	0.0	0.4	0.1	0.8
Conditioned locomotion	0.8	0.9	1.3	-0.9	1.1	1.0	0.8
Cocaine response after cond. corrected	1.1	1.3	2.4	-0.9	1.6	1.4	-0.1
Cocaine response after cond. not corrected	2.1	2.4	4.1	-1.4	2.0	1.8	0.4
Cocaine response before conditioning	0.0	0.1	0.1	-0.3	-0.0	0.1	0.3
Saline control response	0.2	0.2	0.6	-0.8	0.0	0.2	0.5
Condit. Reinf. active minus inactive responses	1.0	1.2	2.4	-0.6	1.6	1.4	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.5	0.3	0.2	-0.8
Condit. Reinf. active responses	0.4	0.6	1.3	-0.2	1.2	0.9	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.2	0.5	0.4	-0.0
Condit. Reinf. lever presses	1.1	1.5	3.9	1.1	-0.7	-0.6	-2.0
Condit. Reinf. lever reinforcers received	0.4	0.5	1.2	-0.1	1.1	0.9	-0.5
Pavlov. Cond. lever latency	1.5	2.1	3.7	-1.7	0.9	1.1	1.9
Pavlov. Cond. magazine entry latency	0.3	0.3	0.4	0.7	-0.6	-0.5	-0.4
Pavlov. Cond. change in total contacts	1.2	1.6	3.9	1.4	-0.5	-0.7	-2.0
Pavlov. Cond. index score	1.2	1.6	2.7	1.5	-0.8	-0.9	-1.6
Pavlov. Cond. latency score	1.1	1.3	2.1	1.4	-0.8	-0.9	-1.4
Pavlov. Cond. lever contacts	1.2	1.7	3.9	1.4	-0.6	-0.7	-2.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.5	0.1	0.1	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.5	0.3	0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	2.7	1.5	-0.8	-0.9	-1.6
Pavlov. Cond. response bias	0.5	0.7	1.6	1.1	-0.2	-0.4	-1.3
Conditioned reinforcement - actives	0.2	0.2	0.5	-0.3	-0.0	-0.1	0.7
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.5	-0.0	-0.4	0.3
Conditioned locomotion	0.2	0.3	0.4	-0.2	-0.7	-0.4	-0.6
Intermittent access intake day 1-15 change	0.1	0.1	0.3	-0.3	-0.5	-0.3	-0.1
Intermittent access intake escalation	0.1	0.1	0.3	-0.2	-0.5	-0.4	-0.1
Intermittent access intake escalation 2	0.6	0.6	1.5	-1.2	0.5	0.7	0.5
Intermitt. access day 1 inactive lever presses	1.0	1.1	2.1	0.8	-1.5	-1.3	-0.4
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	-0.1	-0.5	-0.1	-0.1
Intermitt. access escalation Index	0.5	0.4	1.1	0.6	0.0	-0.3	1.1
Intermittent access day 1 total infusions	0.2	0.2	0.4	0.5	-0.1	-0.3	0.6
Intermittent access day 15 total infusions	0.2	0.2	0.3	0.3	-0.4	-0.6	0.5
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	0.4	-0.5	-0.6	0.1
Intermittent access total infusions	0.2	0.2	0.4	0.5	-0.3	-0.5	0.6
Intermittent access day 1 locomotion	0.8	0.9	1.3	1.1	-0.9	-1.2	-0.4
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.3	-0.2	-0.3	0.2
Intermittent access total locomotion	0.2	0.3	0.5	0.5	-0.6	-0.7	0.2
Intermittent access standard deviation	0.7	0.7	1.1	0.7	-1.0	-1.1	-0.3
Cocaine induced anxiety	0.0	0.0	0.0	-0.2	-0.1	0.0	-0.1
Post-drug Anxiety	0.1	0.1	0.2	-0.4	0.2	0.3	-0.3
Baseline Anxiety	0.0	0.0	0.1	0.1	0.4	0.2	-0.0
Lifetime Intake	0.3	0.3	0.4	0.5	-0.4	-0.7	0.5
Incentive Sensitization - Responses	0.3	0.3	0.9	0.2	0.3	0.1	1.0
Incentive Sensitization - Breakpoint	0.2	0.2	0.9	0.1	0.3	0.1	0.9
Progressive ratio test 1 active lever presses	1.1	1.1	2.2	1.5	-0.7	-1.3	0.4
Progressive ratio test 1 breakpoint	0.8	0.9	1.7	1.3	-0.5	-1.2	0.3
Progressive ratio test 1 inactive lever presses	3.7	4.0	6.6	2.1	-2.2	-2.6	0.4
Progressive ratio test 2 active lever presses	0.6	0.6	0.8	0.9	-0.4	-0.8	0.8
Progressive ratio test 2 breakpoint	0.9	1.0	1.9	1.4	-0.8	-1.2	0.2
Progressive ratio test 2 inactive lever presses	0.9	1.1	1.5	1.1	-1.2	-1.2	0.1
Total sessions with >9 infusions	2.0	2.2	3.6	1.7	-1.5	-1.9	-0.4
Short access day 1 total inactive lever presses	0.1	0.1	0.4	0.1	-0.2	-0.3	-0.7
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.0	-0.3	-0.1	-0.1
Short access day 1 total infusions	0.8	0.9	1.7	1.3	-0.6	-1.2	-0.2
Short access day 10 total infusions	0.1	0.1	0.1	-0.3	0.1	0.0	0.4
Short access total infusions	0.6	0.7	1.1	0.9	-0.8	-1.0	-0.2
Short access day 1 locomotion	1.4	1.5	2.9	1.7	-1.0	-1.5	-0.1
Short access day 10 total locomotion	0.2	0.2	0.6	-0.0	-0.3	-0.2	-0.8
Short access total locomotion	0.1	0.1	0.4	-0.2	-0.1	-0.1	0.7
Compulsive drug intake	0.2	0.2	0.4	0.7	-0.2	-0.4	-0.4
One hour access (0.3 mA shock)	0.5	0.6	1.4	1.2	-0.6	-0.8	-0.3
One hour access (shock baseline)	0.0	0.1	0.2	-0.1	0.1	0.1	0.4
Number of responses in last shaping day	1.0	1.0	1.7	0.9	-1.3	-1.2	0.4
Context. condit. distance diff. score	0.6	0.7	1.8	0.5	-1.3	-0.9	-0.3
Locomotion velocity, session 1	0.7	0.7	1.0	0.9	-0.7	-0.8	-1.0
Locomotion distance, session 1	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.2
Locomotion velocity, session 2	0.3	0.3	0.7	0.6	-0.2	-0.5	-0.8
Locomotion distance, session 2	0.0	0.1	0.1	-0.4	0.2	0.1	-0.0
Locomotion velocity, session 3	0.2	0.2	0.8	-0.3	0.1	0.2	0.9
Locomotion distance, session 3	0.0	0.0	0.1	0.2	-0.2	-0.2	0.1
Stereotopy head waving bouts, day 3	1.2	1.4	2.1	1.3	-1.3	-1.4	-0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.5
Locomotion velocity, session 7	0.2	0.3	0.6	0.4	-0.5	-0.2	-0.8
Locomotion distance, session 7	0.1	0.1	0.1	0.4	-0.3	-0.2	-0.4
Stereotopy head waving bouts, day 7	0.9	1.0	1.5	-1.2	1.1	1.0	0.6
Stereotopy head waving duration, day 7	0.9	1.1	1.9	-1.4	1.0	0.9	0.8
Locomotion velocity, session 8	0.2	0.3	0.9	-0.4	0.2	0.3	-0.9
Locomotion distance, session 8	0.3	0.5	0.9	0.4	-1.0	-0.8	-0.4
Degree of sensitization distance	0.1	0.1	0.2	-0.1	0.2	0.3	-0.4
Degree of sensitization stereotypy	2.0	2.2	3.7	-1.9	1.5	1.6	0.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	0.3	0.2	-0.0	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.0	0.2	0.1	-0.5
Condit. Reinf. active responses	0.2	0.2	0.6	-0.1	0.8	0.5	-0.4
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.0	0.4	0.2	-0.2
Incentive salience index mean	0.2	0.3	0.8	0.2	0.4	0.2	-0.9
Condit. Reinf. lever presses	0.1	0.1	0.1	0.1	0.4	0.2	-0.3
Time in familiar zone, hab. session 1	0.3	0.3	0.7	-0.6	0.2	0.2	0.8
Time in novel zone, hab. session 1	0.2	0.2	0.6	0.6	-0.1	-0.1	-0.8
Total zone transitions, hab. session 1	0.1	0.2	0.2	-0.3	0.5	0.3	-0.5
Total locomotion distance, hab. session 1	0.2	0.2	0.4	-0.3	0.6	0.4	-0.6
Locomotion velocity, hab. session 1	0.1	0.2	0.4	-0.3	0.7	0.4	0.0
Time in familiar zone, hab. session 2	1.4	1.4	1.7	1.2	-1.2	-1.1	-1.3
Time in novel zone, hab. session 2	0.5	0.5	0.6	-0.7	0.6	0.6	0.8
Total zone transitions, hab. session 2	0.2	0.2	0.6	-0.3	0.4	0.1	0.8
Total locomotion distance, hab. session 2	0.4	0.5	1.1	-0.5	0.7	0.4	1.0
Locomotion velocity, hab. session 2	0.5	0.7	1.7	-0.6	0.8	0.5	1.3
Novel to familiar place preference ratio	1.3	1.3	1.6	-1.1	1.3	1.2	1.0
Novelty place preference	1.3	1.4	1.6	-1.1	1.3	1.3	1.1
Time in novel zone, NPP test	1.1	1.2	1.5	-1.1	1.2	1.2	0.9
Total zone transitions, NPP test	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.4
Total locomotion distance, NPP test	0.2	0.2	0.6	0.3	-0.4	-0.3	-0.8
Locomotion velocity, NPP test	0.2	0.3	0.5	0.6	-0.5	-0.5	-0.7
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.4	-0.6	-0.6	0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.8	0.2	0.3	0.1	-0.9
Pavlov. Cond. change in total contacts	0.5	0.5	2.1	0.1	0.1	0.2	-1.4
Pavlov. Cond. index score	0.1	0.2	0.6	0.2	0.2	0.1	-0.7
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.2	0.6	0.5	-0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.1	0.3	0.2	-0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.1	-0.5	-0.4	0.5
Pavlov. Cond. intertrial magazine entries	1.1	1.3	1.8	-1.2	0.9	1.1	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	0.6	-0.0	-0.2	-1.0
Pavlov. Cond. response bias	0.1	0.1	0.3	0.3	0.2	-0.1	-0.6
Bone: apparent density	5.0	8.2	10.5	-2.6	3.2	3.0	2.5
Bone surface	4.7	8.3	10.1	-2.6	3.2	3.0	2.6
Bone volume	4.5	7.5	10.5	-2.3	3.2	2.9	2.4
Bone: connectivity density	3.6	5.6	6.6	-2.5	2.5	2.6	1.8
Bone: cortical apparent density	7.6	9.8	11.1	2.9	-3.3	-3.2	-3.1
Bone: cortical area	0.1	0.1	0.3	0.5	0.1	-0.2	0.1
Bone: cortical porosity	1.8	2.0	4.2	-0.4	1.7	0.9	2.0
Bone: cortical porosity	2.9	3.2	5.6	-0.8	2.1	1.4	2.4
Bone: cortical thickness	2.0	3.3	4.0	2.0	-1.7	-2.0	-1.6
Bone: cortical thickness	1.5	1.7	3.8	1.1	-1.0	-1.0	-1.9
Bone: cortical tissue density	7.2	9.4	10.8	2.8	-3.3	-3.1	-3.1
Bone: elastic displacement	0.3	0.3	1.2	0.0	-0.3	-0.2	-1.1
Bone: elastic work	0.4	0.5	0.8	-0.6	0.9	0.9	0.4
Bone: endosteal estimation	2.6	5.6	7.3	-1.8	2.7	2.5	2.4
Bone: endosteal perimeter	2.9	5.9	7.0	-2.0	2.6	2.6	2.4
Bone: final force	0.5	0.8	2.6	-0.1	0.7	0.4	1.6
Bone: final moment	0.4	0.6	2.1	0.1	0.5	0.2	1.4
Bone: marrow area	2.4	5.2	6.7	-1.7	2.6	2.5	2.3
Bone: maximum diameter	0.1	0.2	0.5	0.2	0.7	0.4	0.5
Bone: maximum force	1.4	2.4	4.4	-1.0	1.6	1.3	2.1
Bone: maximum moment	1.0	1.8	3.6	-0.8	1.3	1.1	1.9
Bone: minimum diameter	0.1	0.2	0.3	0.2	0.6	0.3	0.5
Bone: periosteal estimation	1.0	2.1	3.3	-0.7	1.8	1.4	1.6
Bone: periosteal perimeter	0.9	1.5	2.1	-0.8	1.5	1.3	1.2
Bone: post-yield work	1.1	1.4	2.6	-1.0	1.1	1.0	1.6
Bone: stiffness	2.7	4.3	8.0	-1.5	2.0	1.7	2.8
Bone: tissue strength	1.4	1.3	3.8	-0.8	0.7	0.6	2.0
Bone: trabecular number	4.5	7.0	8.0	-2.6	2.8	2.7	2.4
Bone: trabecular spacing	0.6	0.7	0.8	0.9	-0.9	-0.8	-0.8
Bone: trabecular thickness	1.4	1.7	2.8	-1.2	1.7	1.5	0.8
Bone: trabecular tissue density	2.5	3.5	6.9	2.6	-1.4	-2.2	-0.5
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.5	-0.6	-0.2	-0.3
Distance traveled before self-admin	2.1	2.2	3.0	-1.5	1.7	1.6	1.0
Distance traveled after self-admin	0.2	0.2	0.5	-0.5	-0.3	0.0	-0.7
Delta time in closed arm before/after self-admin	0.6	0.6	0.8	0.9	-0.8	-0.9	0.2
Delta time in open arm before/after self-admin	4.5	4.3	7.5	-1.7	2.7	2.3	1.2
Diff in mean of infusions in LGA sessions	0.6	0.6	1.2	-0.9	0.7	1.1	0.0
Extinction: sum of active levers before priming	1.4	1.5	2.3	-1.5	1.0	1.3	1.0
Active lever presses in extinction session 6	0.1	0.1	0.1	0.2	0.3	0.4	-0.1
Delta distance traveled before/after self-admin	1.0	1.0	1.5	0.7	-1.2	-1.0	-1.1
Delta ambulatory time before/after self-admin	1.3	1.4	1.6	1.1	-1.3	-1.3	-1.1
Time in closed arm before self-admin	2.3	2.6	5.5	-0.9	2.3	1.4	1.4
Time in closed arm after self-admin	0.4	0.5	1.0	-0.5	1.0	0.8	0.1
Time in open arm before self-admin	4.5	4.8	8.7	1.8	-2.9	-2.4	-1.2
Time in open arm after self-admin	0.2	0.2	0.4	-0.2	0.6	0.5	0.5
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.2	-0.9	0.8	1.1	0.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.5	-0.4	-0.4	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.4	0.6	-0.1	0.3
Time to tail flick, test, before self-admin	0.8	0.8	1.4	0.9	-0.6	-0.8	-1.2
Time to tail flick, test, after self-admin	0.6	0.6	0.9	0.7	-0.9	-1.0	0.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	0.2	0.0	0.1
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	0.7	-0.9	-0.8	0.1
Ambulatory time before self-admin	2.2	2.4	3.6	-1.9	1.4	1.7	0.9
Ambulatory time after self-admin	0.5	0.5	1.5	-0.4	-0.6	-0.2	-1.2
Total heroin consumption	0.0	0.0	0.0	-0.2	-0.1	0.2	0.2
Area under the delay curve	0.1	0.1	0.2	-0.3	-0.1	0.3	-0.5
Delay disc. indifference point, 0s delay	0.6	0.6	1.2	-0.2	-1.1	-0.3	-1.1
Delay disc. indifference point, 16s delay	0.0	0.0	0.2	-0.1	0.1	0.1	-0.4
Delay disc. indifference point, 2s delay	0.7	0.8	2.1	-0.7	-0.6	0.4	-1.5
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.5	-0.6	-0.6	-0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.8	-0.1	-0.6	-0.2	-0.9
Delay disc. indifference point, 8s delay	0.6	0.6	0.9	-0.8	0.7	0.9	0.6
Delay discount exponential model param	0.1	0.1	0.2	0.3	0.0	-0.3	0.5
Delay discount hyperbolic model param	0.1	0.2	0.4	0.3	0.2	-0.3	0.6
Fecal boli incidents, locomotor time 1	2.1	2.3	3.6	-1.3	1.9	1.8	0.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.4	-0.5	-0.4	-0.3
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.1	-0.2	0.8	0.7	-1.1
Bouts of movement, locomotor time 1	0.5	0.5	1.5	1.2	-0.0	-0.4	-0.7
Total resting periods, locomotor time 1	1.6	1.8	3.6	1.9	-0.7	-1.0	-1.5
Rest time, locomotor task time 1	2.4	2.7	5.6	2.4	-1.0	-1.8	-1.0
Distance moved, locomotor task time 1	1.9	2.1	4.3	-2.1	1.1	1.6	0.4
Vertical activity count, locomotor time 1	0.7	0.7	1.8	-1.3	0.2	0.7	0.6
Time >=10cm from walls, locomotor time 2	1.2	1.3	2.1	-1.1	1.3	1.4	-0.5
Bouts of movement, locomotor time 2	0.5	0.5	1.9	-0.1	-0.1	0.2	-1.4
Total resting periods, locomotor time 2	0.7	0.7	2.5	0.4	-0.3	-0.1	-1.6
Rest time, locomotor task time 2	1.8	2.1	4.8	2.2	-0.9	-1.6	-0.4
Distance moved, locomotor task time 2	1.5	1.8	3.5	-1.9	1.0	1.6	0.1
Vertical activity count, locomotor time 2	0.7	0.7	2.1	-1.4	0.1	0.9	-0.1
Weight adjusted by age	0.8	0.9	1.5	-0.9	1.2	1.0	0.4
Seeking ratio, delayed vs. immediate footshock	3.0	3.5	4.6	-2.1	1.9	2.1	1.3
Locomotion in novel chamber	1.5	1.8	2.6	1.2	-1.6	-1.2	-1.4
Locomotion in novel chamber post-restriction	1.6	1.9	2.3	1.5	-1.4	-1.5	-1.0
Progressive ratio	0.9	1.1	1.7	1.3	-0.9	-1.3	-0.4
Food seeking constrained by brief footshock	0.4	0.4	0.8	-0.9	0.4	0.6	0.7
Seeking ratio, punishment vs. effort	2.5	3.0	4.8	-2.2	1.4	1.9	1.3
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.2	0.2	0.1	0.6
Run reversals in cocaine runway, males	0.8	0.8	2.0	0.9	-0.3	-0.4	-1.4
Latency to leave start box in cocaine runway	4.3	4.7	6.6	1.7	-2.6	-2.2	-2.1
Latency to leave start box in cocaine runway, F	3.4	3.7	5.9	1.5	-2.4	-2.0	-1.6
Latency to leave start box in cocaine runway, M	0.9	0.9	1.5	0.8	-0.7	-0.9	-1.2
Cd content in liver	0.4	0.5	1.8	-0.2	0.3	0.1	1.3
Co content in liver	1.0	1.1	1.6	1.2	-1.1	-1.3	-0.4
Cu content in liver	0.0	0.0	0.0	0.0	0.2	0.1	-0.2
Fe content in liver	0.9	1.1	1.7	-0.8	1.3	1.1	1.0
K content in liver	0.1	0.1	0.2	-0.4	0.2	0.3	-0.0
Mg content in liver	0.9	1.0	1.8	-1.4	0.8	1.1	0.5
Mn content in liver	1.7	1.9	2.3	1.3	-1.5	-1.4	-1.3
Na content in liver	0.5	0.5	1.0	-0.6	1.0	0.9	0.1
Rb content in liver	1.6	2.0	3.1	-1.7	1.5	1.8	0.2
Se content in liver	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.3
Sr content in liver	1.5	1.4	2.2	1.5	-0.9	-1.5	0.7
Zn content in liver	0.0	0.0	0.1	0.2	-0.1	-0.2	0.3