Hub : Genes

Pan2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability ENSRNOG00000032441 0.03 0.02 5.9e-03 0 0.01 -0 0 9.6e-02 6.7e-02 7.3e-01 1.3e-01
2 Brain gene expression ENSRNOG00000032441 0.04 0.03 6.8e-03 0.02 0.01 0.02 0.02 3.5e-03 4.3e-02 1.1e-02 9.5e-03
3 NAcc gene expression ENSRNOG00000032441 0.05 0.04 3.6e-04 0.04 0.04 0.05 0.04 4.5e-04 2.8e-04 1.7e-04 2.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail8.527.528.75.4-5.0-5.3
BMI without tail1.63.43.91.9-1.7-2.0
Body weight1.45.96.12.5-2.4-2.4
Epididymis fat weight0.10.20.4-0.40.60.4
Glucose2.03.03.21.8-1.7-1.7
Heart weight0.00.00.00.2-0.2-0.2
Left kidney weight0.10.20.60.3-0.7-0.2
Right kidney weight0.20.60.8-0.80.50.9
Tail length5.215.615.9-4.04.03.9
Length with tail1.86.77.4-2.72.42.7
Length without tail0.10.30.60.4-0.8-0.2
Liver weight, left1.72.73.11.7-1.5-1.8
Liver weight, right1.21.92.01.3-1.4-1.4
Parametrial fat weight0.00.10.1-0.20.40.1
Retroperitoneal fat weight2.68.59.23.0-2.7-3.0
Intraocular pressure0.50.71.1-0.71.10.6
Extensor digitorum longus weight5.823.225.85.0-4.3-5.1
Soleus weight6.920.221.04.6-4.4-4.5
Tibialis anterior weight1.34.54.82.2-2.1-2.1
Tibia length1.23.33.5-1.81.91.8
Number of licking bursts3.44.05.02.1-1.6-2.2
Food consumed during 24 hour testing period0.50.60.70.8-0.7-0.8
Times rat made contact with spout1.11.31.61.2-0.9-1.3
Mean time between licks in bursts0.91.21.5-1.11.21.0
Mean num. licks in bursts0.81.01.2-1.00.81.1
Std. dev. time between licks in bursts0.40.50.7-0.80.30.8
Water consumed over 24 hours0.91.11.41.0-1.2-0.9
Indifference point 0 sec4.37.07.52.6-2.7-2.6
Indifference point AUC0.70.80.9-0.91.00.9
Indifference point function ln k0.20.30.30.5-0.6-0.5
Indifference point function log k0.20.30.30.5-0.6-0.5
Delay discounting total patch changes 0 sec4.06.56.72.5-2.6-2.5
Delay discounting total patch changes 12 sec1.92.52.91.7-1.3-1.7
Delay discounting total patch changes 18 sec0.00.00.00.2-0.1-0.2
Delay discounting total patch changes 24 sec0.50.70.70.8-0.8-0.8
Delay discounting total patch changes 6 sec2.33.53.61.8-1.9-1.9
Delay discounting time to switch 0 sec0.30.40.80.5-0.9-0.4
Delay discounting water rate 0 sec0.50.81.11.0-0.6-1.0
Delay discounting water rate 12 sec0.81.21.61.2-0.8-1.3
Delay discounting water rate 18 sec0.10.20.40.10.6-0.3
Delay discounting water rate 24 sec1.21.72.71.5-0.5-1.7
Delay discounting water rate 6 sec0.40.61.4-0.61.20.4
Locomotor activity3.55.66.5-2.52.02.6
Locomotor testing distance1.32.12.5-1.51.21.6
Locomotor testing rearing0.00.00.0-0.00.1-0.0
Light reinforcement 13.86.97.3-2.72.52.7
Light reinforcement 21.11.51.7-1.21.31.2
Reaction time number correct0.91.21.61.2-0.8-1.2
Reaction time mean minus median1.62.12.6-1.51.11.6
Reaction time mean minus median AUC1.72.13.2-1.60.81.8
Reaction time num false alarms0.60.91.01.0-0.8-1.0
Reaction time num false alarms AUC0.71.01.21.1-0.7-1.1
Reaction time trials correct on left0.91.21.61.2-0.8-1.2
Reaction time trials on left0.81.21.51.2-0.8-1.2
Reaction time mean1.31.82.3-1.41.01.5
Reaction time mean AUC0.60.71.0-0.90.51.0
Median of all reaction times0.60.91.1-1.00.71.0
Reaction time omissions0.00.00.1-0.0-0.20.0
Reaction time false alarm rate0.10.10.20.4-0.4-0.4
Reaction time premature initiation rate1.52.02.6-1.41.61.2
Reaction time premature initiations0.50.71.4-0.71.20.5
Std. dev. reaction times0.91.21.7-1.20.81.3
Reaction time trials completed0.81.21.51.2-0.8-1.2
Reaction time trials AUC0.91.31.71.3-0.8-1.3
Social response proportion1.11.21.2-1.11.01.1
Social responses9.812.713.7-3.73.33.7
Social time1.11.51.61.3-1.1-1.3
Conditioned locomotion0.91.01.51.1-0.6-1.2
Cocaine response after cond. corrected2.22.53.41.7-1.2-1.8
Cocaine response after cond. not corrected2.42.63.61.7-1.2-1.9
Cocaine response before conditioning0.50.60.7-0.80.70.8
Saline control response0.40.50.60.8-0.6-0.7
Condit. Reinf. active minus inactive responses2.02.53.2-1.51.81.4
Condit. Reinf. active-inactive response ratio0.60.71.4-0.61.20.4
Condit. Reinf. active responses1.31.82.0-1.41.31.3
Condit. Reinf. inactive responses0.30.30.5-0.60.20.7
Condit. Reinf. lever presses2.83.94.3-1.92.11.9
Condit. Reinf. lever reinforcers received1.01.31.4-1.21.21.1
Pavlov. Cond. lever latency1.72.32.71.6-1.4-1.6
Pavlov. Cond. magazine entry latency2.73.13.3-1.81.61.8
Pavlov. Cond. change in total contacts0.71.01.1-1.00.91.0
Pavlov. Cond. index score2.22.83.0-1.71.61.7
Pavlov. Cond. latency score2.43.03.3-1.81.61.8
Pavlov. Cond. lever contacts1.42.02.0-1.41.41.4
Pavlov. Cond. magazine entry number2.32.83.01.7-1.5-1.7
Pavlov. Cond. intertrial magazine entries0.91.21.41.2-0.9-1.2
Pavlov. Cond. lever-magazine prob. diff.2.32.93.2-1.81.61.8
Pavlov. Cond. response bias2.33.23.2-1.81.81.8
Conditioned reinforcement - actives0.00.00.1-0.1-0.40.0
Conditioned reinforcement - inactives1.41.62.21.3-1.0-1.5
Conditioned locomotion2.22.63.0-1.71.41.7
Intermittent access intake day 1-15 change0.20.20.2-0.40.50.3
Intermittent access intake escalation0.10.10.4-0.10.6-0.0
Intermittent access intake escalation 20.50.50.9-0.61.00.5
Intermitt. access day 1 inactive lever presses0.10.10.2-0.00.5-0.2
Intermitt. access day 15 inactive lever presses0.70.81.2-0.81.10.7
Intermitt. access escalation Index0.10.10.1-0.2-0.40.3
Intermittent access day 1 total infusions0.40.50.60.7-0.8-0.6
Intermittent access day 15 total infusions0.20.20.30.5-0.4-0.6
Intermittent access terminal intake (last 3 days)0.30.30.60.5-0.7-0.5
Intermittent access total infusions0.50.60.60.8-0.8-0.8
Intermittent access day 1 locomotion0.00.00.00.10.1-0.0
Intermittent access day 15 total locomotion0.30.30.4-0.60.60.4
Intermittent access total locomotion0.20.20.3-0.50.40.5
Intermittent access standard deviation0.10.10.2-0.20.40.2
Cocaine induced anxiety1.71.92.5-1.51.11.6
Post-drug Anxiety0.40.40.8-0.70.10.9
Baseline Anxiety0.00.00.00.1-0.0-0.2
Lifetime Intake1.41.52.01.2-1.4-1.1
Incentive Sensitization - Responses0.10.10.1-0.30.20.2
Incentive Sensitization - Breakpoint0.10.10.2-0.40.20.4
Progressive ratio test 1 active lever presses1.71.71.81.3-1.3-1.3
Progressive ratio test 1 breakpoint1.81.81.81.4-1.4-1.3
Progressive ratio test 1 inactive lever presses0.10.10.20.1-0.4-0.2
Progressive ratio test 2 active lever presses0.70.80.90.8-1.0-0.9
Progressive ratio test 2 breakpoint0.20.30.50.4-0.7-0.4
Progressive ratio test 2 inactive lever presses0.40.50.80.6-0.9-0.6
Total sessions with >9 infusions0.60.71.60.5-1.3-0.4
Short access day 1 total inactive lever presses0.00.00.10.1-0.3-0.2
Short access day 10 total inactive lever presses0.00.00.10.10.0-0.3
Short access day 1 total infusions1.51.63.11.0-1.8-0.9
Short access day 10 total infusions1.11.21.41.0-1.2-1.0
Short access total infusions2.42.64.21.4-2.0-1.3
Short access day 1 locomotion0.00.00.0-0.2-0.20.2
Short access day 10 total locomotion1.51.62.1-1.31.51.0
Short access total locomotion0.10.10.1-0.40.20.4
Compulsive drug intake0.20.20.30.5-0.6-0.5
One hour access (0.3 mA shock)0.50.60.70.7-0.8-0.8
One hour access (shock baseline)0.10.20.20.4-0.2-0.5
Number of responses in last shaping day0.80.80.9-0.90.90.9
Context. condit. distance diff. score0.20.30.30.5-0.5-0.5
Locomotion velocity, session 10.10.10.40.2-0.6-0.0
Locomotion distance, session 10.20.20.4-0.5-0.10.6
Locomotion velocity, session 21.11.32.0-1.30.61.4
Locomotion distance, session 22.63.85.1-2.11.42.3
Locomotion velocity, session 35.66.66.6-2.62.62.6
Locomotion distance, session 30.10.10.2-0.30.40.3
Stereotopy head waving bouts, day 36.07.27.6-2.82.52.8
Stereotopy head waving duration, day 33.74.54.9-2.22.02.2
Locomotion velocity, session 70.10.10.1-0.30.10.4
Locomotion distance, session 70.10.10.10.30.0-0.4
Stereotopy head waving bouts, day 70.80.91.4-1.00.61.2
Stereotopy head waving duration, day 70.70.81.3-1.00.51.1
Locomotion velocity, session 81.31.62.4-1.30.71.6
Locomotion distance, session 80.40.60.8-0.80.60.9
Degree of sensitization distance0.70.70.70.8-0.8-0.8
Degree of sensitization stereotypy0.10.10.20.2-0.5-0.1
Condit. Reinf. active minus inactive responses2.22.52.7-1.61.51.6
Condit. Reinf. active-inactive response ratio0.30.30.4-0.50.60.5
Condit. Reinf. active responses3.03.74.4-2.01.62.1
Condit. Reinf. inactive responses1.51.82.4-1.41.01.5
Incentive salience index mean1.41.72.2-1.41.01.5
Condit. Reinf. lever presses0.30.40.8-0.70.10.9
Time in familiar zone, hab. session 15.95.66.2-2.32.52.3
Time in novel zone, hab. session 14.14.05.31.9-2.3-1.8
Total zone transitions, hab. session 10.50.61.0-0.90.41.0
Total locomotion distance, hab. session 11.62.33.5-1.70.91.9
Locomotion velocity, hab. session 11.82.63.6-1.71.11.9
Time in familiar zone, hab. session 25.45.76.8-2.32.62.2
Time in novel zone, hab. session 26.16.17.62.4-2.8-2.3
Total zone transitions, hab. session 20.50.71.50.6-1.2-0.4
Total locomotion distance, hab. session 20.30.50.8-0.70.30.9
Locomotion velocity, hab. session 20.40.51.0-0.80.21.0
Novel to familiar place preference ratio3.03.24.41.7-2.1-1.5
Novelty place preference2.02.03.01.3-1.7-1.1
Time in novel zone, NPP test2.72.83.91.6-2.0-1.4
Total zone transitions, NPP test0.30.40.70.6-0.8-0.4
Total locomotion distance, NPP test0.10.10.20.1-0.50.1
Locomotion velocity, NPP test0.10.10.2-0.3-0.10.5
Pavlov. Cond. lever latency0.10.10.20.30.1-0.5
Pavlov. Cond. magazine entry latency1.82.32.5-1.51.61.5
Pavlov. Cond. change in total contacts0.10.20.20.4-0.4-0.3
Pavlov. Cond. index score0.50.70.9-0.90.61.0
Pavlov. Cond. latency score0.50.71.1-0.90.51.0
Pavlov. Cond. lever contacts0.10.10.2-0.2-0.30.4
Pavlov. Cond. magazine entry number0.70.80.90.9-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.20.50.1
Pavlov. Cond. lever-magazine prob. diff.0.70.91.1-1.00.71.1
Pavlov. Cond. response bias0.91.11.3-1.11.01.1
Bone: apparent density0.20.30.8-0.1-0.90.3
Bone surface0.40.60.8-0.6-0.90.8
Bone volume0.40.61.4-0.3-1.20.6
Bone: connectivity density0.10.20.4-0.1-0.60.3
Bone: cortical apparent density1.72.22.21.5-1.5-1.5
Bone: cortical area1.21.83.01.1-1.7-1.0
Bone: cortical porosity0.00.00.0-0.1-0.20.2
Bone: cortical porosity0.20.20.50.3-0.7-0.2
Bone: cortical thickness1.82.93.71.6-1.9-1.6
Bone: cortical thickness0.91.01.21.1-0.9-1.1
Bone: cortical tissue density1.21.51.61.2-1.2-1.3
Bone: elastic displacement0.00.00.0-0.0-0.0-0.0
Bone: elastic work0.70.91.20.9-1.1-0.8
Bone: endosteal estimation0.81.72.41.2-1.5-1.1
Bone: endosteal perimeter0.10.30.4-0.60.10.7
Bone: final force3.04.96.42.1-2.5-2.0
Bone: final moment2.94.76.22.1-2.5-1.9
Bone: marrow area0.71.52.11.1-1.4-1.0
Bone: maximum diameter0.20.40.7-0.7-0.00.8
Bone: maximum force3.35.77.22.3-2.7-2.2
Bone: maximum moment3.25.67.02.3-2.6-2.1
Bone: minimum diameter0.30.61.20.6-1.1-0.5
Bone: periosteal estimation1.22.54.21.4-2.1-1.2
Bone: periosteal perimeter0.10.10.40.1-0.70.0
Bone: post-yield work0.50.60.60.8-0.8-0.8
Bone: stiffness5.38.39.62.8-3.1-2.7
Bone: tissue strength5.14.95.42.2-2.3-2.1
Bone: trabecular number0.60.91.5-1.10.41.2
Bone: trabecular spacing0.30.40.70.60.3-0.8
Bone: trabecular thickness0.60.72.00.0-1.40.3
Bone: trabecular tissue density6.69.310.13.1-2.8-3.2
Breakpoint value in progressive ratio session2.32.62.9-1.61.71.5
Distance traveled before self-admin1.01.11.3-1.10.91.1
Distance traveled after self-admin0.20.20.2-0.50.30.5
Delta time in closed arm before/after self-admin0.90.81.41.0-0.3-1.2
Delta time in open arm before/after self-admin1.31.21.51.1-1.2-1.0
Diff in mean of infusions in LGA sessions2.22.52.6-1.61.61.5
Extinction: sum of active levers before priming3.63.75.1-1.82.31.7
Active lever presses in extinction session 61.41.41.5-1.21.11.2
Delta distance traveled before/after self-admin0.10.10.10.2-0.3-0.2
Delta ambulatory time before/after self-admin0.10.10.20.2-0.4-0.2
Time in closed arm before self-admin0.20.20.40.3-0.7-0.2
Time in closed arm after self-admin0.40.40.50.6-0.7-0.6
Time in open arm before self-admin0.20.20.3-0.40.50.3
Time in open arm after self-admin1.01.11.41.2-0.9-1.1
Sum of active levers in priming session hrs 5-60.40.30.4-0.60.60.6
Time to tail flick, vehicle, before self-admin1.31.31.8-1.30.61.3
Time to tail flick, vehicle, after self-admin0.30.30.7-0.50.80.4
Time to tail flick, test, before self-admin0.90.91.4-1.00.61.2
Time to tail flick, test, after self-admin0.10.10.2-0.3-0.10.4
Delta time to tail flick, vehicle, before/after SA0.70.71.11.0-0.2-1.0
Delta time to tail flick, test, before/after SA0.10.10.3-0.20.50.1
Ambulatory time before self-admin0.20.20.4-0.60.20.6
Ambulatory time after self-admin0.00.00.0-0.20.00.2
Total heroin consumption2.63.13.4-1.81.61.8
Area under the delay curve0.00.00.10.1-0.30.0
Delay disc. indifference point, 0s delay1.31.42.51.0-1.6-0.8
Delay disc. indifference point, 16s delay0.30.30.3-0.50.50.6
Delay disc. indifference point, 2s delay0.20.20.50.4-0.7-0.3
Delay disc. indifference point, 24s delay0.20.20.30.5-0.5-0.4
Delay disc. indifference point, 4s delay0.30.40.6-0.70.20.8
Delay disc. indifference point, 8s delay0.10.10.10.3-0.2-0.3
Delay discount exponential model param0.00.00.10.00.2-0.1
Delay discount hyperbolic model param0.10.10.2-0.20.40.1
Fecal boli incidents, locomotor time 10.60.60.90.9-0.3-1.0
Change in fecal boli incidents, locomotor task0.50.50.9-0.80.30.9
Time >=10cm from walls, locomotor time 10.60.61.00.7-1.0-0.6
Bouts of movement, locomotor time 10.50.50.7-0.70.80.6
Total resting periods, locomotor time 11.21.41.5-1.21.21.1
Rest time, locomotor task time 10.60.60.7-0.80.70.8
Distance moved, locomotor task time 10.80.91.40.8-1.2-0.7
Vertical activity count, locomotor time 11.51.61.71.2-1.3-1.3
Time >=10cm from walls, locomotor time 21.31.41.71.2-0.9-1.3
Bouts of movement, locomotor time 20.20.30.4-0.60.20.7
Total resting periods, locomotor time 20.20.20.4-0.50.10.6
Rest time, locomotor task time 20.10.10.2-0.20.10.4
Distance moved, locomotor task time 20.10.10.10.3-0.1-0.4
Vertical activity count, locomotor time 21.51.62.01.3-1.1-1.4
Weight adjusted by age0.00.00.00.10.1-0.1
Seeking ratio, delayed vs. immediate footshock1.11.31.6-1.30.81.3
Locomotion in novel chamber0.30.40.40.6-0.6-0.7
Locomotion in novel chamber post-restriction4.04.74.9-2.22.22.1
Progressive ratio1.41.61.81.3-1.2-1.3
Food seeking constrained by brief footshock2.22.62.9-1.61.71.6
Seeking ratio, punishment vs. effort2.93.63.7-1.91.91.9
Run reversals in cocaine runway, females1.91.92.2-1.51.21.5
Run reversals in cocaine runway, males2.52.42.8-1.71.31.6
Latency to leave start box in cocaine runway0.20.20.70.2-0.80.0
Latency to leave start box in cocaine runway, F0.30.41.10.2-1.0-0.0
Latency to leave start box in cocaine runway, M0.00.00.00.20.1-0.2
Cd content in liver0.30.30.40.6-0.4-0.5
Co content in liver1.31.51.9-1.21.41.1
Cu content in liver1.31.62.31.1-1.5-1.1
Fe content in liver0.60.70.80.8-0.7-0.9
K content in liver0.40.40.6-0.70.40.8
Mg content in liver0.30.30.6-0.60.20.8
Mn content in liver0.40.50.8-0.7-0.10.9
Na content in liver0.10.10.20.2-0.4-0.1
Rb content in liver0.81.01.80.8-1.4-0.8
Se content in liver0.00.10.1-0.20.20.3
Sr content in liver0.10.10.3-0.30.50.1
Zn content in liver2.22.43.8-1.42.01.2